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lupus and pneumonitis

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https://www.readbyqxmd.com/read/29038734/dilemma-in-management-a-patient-with-active-systemic-lupus-erythematosus-presenting-with-pulmonary-cavitary-lesion
#1
Van T La, Kathleen Teves, Vaneet K Sandhu
Pulmonary manifestations of systemic lupus erythematosus (SLE) include, but are not limited to, pneumonia, interstitial pneumonitis, atelectasis and pleural effusion. Cavitary lung lesions are rarely associated with SLE. We present herein the case of a female patient with SLE and lupus nephritis who presented to the hospital with respiratory failure, rash and arthralgias. She was found to have a cavitary lung lesion most concerning for infection. However, despite an extensive inpatient antibiotic course, her symptoms persisted...
October 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/28932614/acute-low-dose-hydralazine-induced-lupus-pneumonitis
#2
Sarah K Holman, Donique Parris, Sarah Meyers, Jason Ramirez
A 35-year-old female was started on hydralazine 10 mg orally three times a day for treatment of postpartum hypertension. Three months later, after multiple unsuccessful courses of prednisone and antibiotics for presumed pneumonia and asthma exacerbations, her respiratory symptoms progressed in severity and she developed resting hypoxia. Previous diagnostic work-up included spirometry with a restrictive pattern, chest CT showing bilateral basilar consolidation, negative BAL, and nonspecific findings on lung biopsy of mild inflammatory cells...
2017: Case Reports in Pulmonology
https://www.readbyqxmd.com/read/28719617/microrna-155-deficiency-leads-to-decreased-autoantibody-levels-and-reduced-severity-of-nephritis-and-pneumonitis-in-pristane-induced-lupus
#3
Harald Leiss, Wilhelm Salzberger, Barbara Jacobs, Irina Gessl, Nicolas Kozakowski, Stephan Blüml, Antonia Puchner, Attila Kiss, Bruno K Podesser, Josef S Smolen, Georg H Stummvoll
OBJECTIVE: We herein examine the role of endogenous miR155 in the development of systemic manifestations in pristane induced lupus. MATERIALS AND METHODS: Systemic lupus in miR155-deficient and wild type mice was induced upon injection of pristane and analyzed after 8 months, PBS-injected mice served as controls. Glomerulonephritis and pneumonitis were quantified using the kidney biopsy score and a newly adapted histomorphometric image analysis system; lung tissue was further analyzed by tissue cytometry...
2017: PloS One
https://www.readbyqxmd.com/read/28675998/cardiovascular-and-pulmonary-manifestations-of-systemic-lupus-erythematosus
#4
M B Urowitz, Konstantinos Tselios
BACKGROUND: Systemic lupus erythematosus (SLE) is characterized by various clinical manifestations and immunologic abnormalities. Among clinical manifestations, cardiovascular and respiratory system involvement is increasingly recognized as critical for patients' prognosis. OBJECTIVE: Heart involvement, most commonly presents with pericarditis. However, valvular disease and less often myocarditis may be detected. METHOD: Accelerated atherosclerosis is currently considered as one of the most important co-morbidities of SLE with cardiovascular events being one of the leading causes of death at relatively young ages...
July 4, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27728671/lupus-pneumonitis-the-great-masquerader
#5
Akash Roy, Bhattacharya Pk, Lyngdoh M, M D Jamil, Talukdar K
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27728617/systemic-lupus-erythematosus-presenting-as-fulminent-lupus-pneumonitis
#6
Avinash Rao U, H K Aggarwal
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27472273/adverse-events-associated-with-immune-checkpoint-blockade-in-patients-with-cancer-a-systematic-review-of-case-reports
#7
REVIEW
Noha Abdel-Wahab, Mohsin Shah, Maria E Suarez-Almazor
BACKGROUND: Three checkpoint inhibitor drugs have been approved by the US Food and Drug Administration for use in specific types of cancers. While the results are promising, severe immunotherapy-related adverse events (irAEs) have been reported. OBJECTIVES: To conduct a systematic review of case reports describing the occurrence of irAEs in patients with cancer following checkpoint blockade therapy, primarily to identify potentially unrecognized or unusual clinical findings and toxicity...
2016: PloS One
https://www.readbyqxmd.com/read/27347044/acute-lupus-pneumonitis-followed-by-intestinal-pseudo-obstruction-in-systemic-lupus-erythematosus-a-case-report
#8
Caihong Ji, Xing Yu, Yong Wang, Lufeng Shi
Intestinal pseudo-obstruction (IpsO) and acute lupus pneumonitis (ALP) are uncommon severe complications of systemic lupus erythematosus (SLE). The present study reports the case of a 26-year-old female who presented with abdominal pain, nausea and vomiting as initial symptoms. Computed tomography (CT) scanning revealed the jejunal wall was thickened and streaky, mimicking the presentation of intestinal obstruction. Following emergency surgery, the patient's general condition was aggravated, with evident limb erythematous rashes...
July 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27339374/systemic-lupus-erythematosus-presenting-as-fulminant-lupus-pneumonitis-a-rare-case-report
#9
H K Aggarwal, D Jain, A Mittal, A Rao, R K Yadav, P Jain
We report a case of 19 year-old female patient diagnosed as systemic lupus erythematosus (SLE) presented with fever and diffuse cutaneous lesions. During the hospital stay she had acute pneumonia, pleural effusion and respiratory failure, which required intensive care unit (ICU) care and mechanical ventilator support. A fulminant course of the disease, decreased values of complement levels and positive antinuclear antibodies (ANA) in pleural fluid and repeated negative sputum for acid-fast bacillus, blood cultures enabled diagnosis of fulminant lupus pneumonitis...
June 23, 2016: Reumatismo
https://www.readbyqxmd.com/read/27125293/lupus-pneumonitis-as-the-initial-presentation-of-systemic-lupus-erythematosus-case-series-from-a-single-institution
#10
S A Wan, C L Teh, A T Jobli
Objective The aim of this study was to examine the clinical features, treatment and outcome of systemic lupus erythematosus (SLE) patients in our centre who presented with lupus pneumonitis as the initial manifestation. Methods We performed a retrospective review of all patients who presented with lupus pneumonitis during the initial SLE manifestation from March 2006 to March 2015. Results There were a total of five patients in our study who presented with fever and cough as the main clinical features. All patients had pulmonary infiltrates on chest radiographs...
November 2016: Lupus
https://www.readbyqxmd.com/read/26557260/rituximab-induced-interstitial-lung-disease-five-case-reports
#11
Matiuallah Naqibullah, Saher B Shaker, Karen S Bach, Elisabeth Bendstrup
Rituximab (RTX), a mouse/human chimeric anti-CD20 IgG1 monoclonal antibody has been effectively used as a single agent or in combination with chemotherapy regimen to treat lymphoma since 1997. In addition, it has been used to treat idiopathic thrombocytopenic purpura, systemic lupus erythematous, rheumatoid arthritis, and autoimmune hemolytic anemia. Recently, RTX has also been suggested for the treatment of certain connective tissue disease-related interstitial lung diseases (ILD) and hypersensitivity pneumonitis...
2015: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/26142172/life-threatening-acute-pneumonitis-in-mixed-connective-tissue-disease-a-case-report-and-literature-review
#12
REVIEW
Eva Rath, Shahin Zandieh, Alexander Löckinger, Mirko Hirschl, Klaus Klaushofer, Jochen Zwerina
Mixed connective tissue disease (MCTD) is a rare connective tissue disease frequently involving the lungs. The main characteristic is a systemic sclerosis-like picture of slowly progressing interstitial lung disease consistent with lung fibrosis, while pulmonary arterial hypertension is rare. Herein, we present a case of a newly diagnosed MCTD patient developing life-threatening acute pneumonitis similar to lupus pneumonitis. Previous literature on this exceptionally rare complication of MCTD is reviewed and differential diagnosis and management discussed...
October 2015: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/25890083/regulatory-t-cell-deficient-scurfy-mice-develop-systemic-autoimmune-features-resembling-lupus-like-disease
#13
Eva N Hadaschik, Xiaoying Wei, Harald Leiss, Britta Heckmann, Birgit Niederreiter, Günter Steiner, Walter Ulrich, Alexander H Enk, Josef S Smolen, Georg H Stummvoll
INTRODUCTION: Scurfy mice are deficient in regulatory T cells (Tregs), develop a severe, generalized autoimmune disorder that can affect almost every organ and die at an early age. Some of these manifestations resemble those found in systemic lupus erythematosus (SLE). In addition, active SLE is associated with low Treg numbers and reduced Treg function, but direct evidence for a central role of Treg malfunction in the pathophysiology of lupus-like manifestations is still missing. In the present study, we characterize the multiorgan pathology, autoantibody profile and blood count abnormalities in scurfy mice and show their close resemblances to lupus-like disease...
2015: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/25766350/systemic-lupus-erythematosus-presenting-as-acute-lupus-pneumonitis-in-a-young-female
#14
B Chattopadhyay, A Chatterjee, A Maiti, N B Debnath
Acute lupus pneumonitis is a rare initial presentation of systemic lupus erythematosus (SLE). We report a 19-year-old female presenting with fever and recurrent hemoptysis with radiological evidence of parenchymal lung involvement with mild pleural effusion. Subsequent development of malar and discoid rash with anti-nuclear antibodies (ANA) and anti-dsDNA positivity clinched the diagnosis. Her clinical signs and symptoms resolved with a course of intravenous pulse methyl-prednisolone along with radiological resolution...
April 2015: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/25348483/sub-acute-cutaneous-lupus-erythematosus-following-nitrofurantoin-causative-or-coincidental
#15
Jill Murie, Monica Agarwal
A 70-year-old woman presented with progressive skin lesions on the face, limbs and trunk in the absence of systemic illness. Three months earlier, she had been prescribed six months prophylactic nitrofurantoin for recurrent urinary tract infections, treated with nitrofurantoin and trimethoprim. Positive immunology and histological inflammatory changes in a skin biopsy were consistent with a diagnosis of sub-acute cutaneous lupus erythematosus. Following treatment with topical steroids, the skin lesions regressed, but alopecia followed and required hydroxychloroquine...
November 2014: Scottish Medical Journal
https://www.readbyqxmd.com/read/25334405/acute-interstitial-pneumonia-presenting-as-diffuse-alveolar-damage-with-positive-scl-70-antibodies-cart-before-the-horse
#16
Mohammed Moizuddin, Muhammed Imtiaz, Mohammed Nayeem, Ria Gripaldo
Interstitial Lung Disease Case Report PostersSESSION TYPE: Affiliate Case Report PosterPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Interstitial Lung disease (ILD) is generally a late feature in patients with progressive systemic sclerosis (PSS). We report a rare case of 30 year old female patient who presented with acute respiratory distress syndrome, noted to have diffuse alveolar damage (DAD) on tranbronchial lung biopsy and elevated serum Scl-70 antibodies with no clinical evidence of SclerodermaCASE PRESENTATION: 30 year old non-smoker female patient with presented with progressively worsening shortness of breath, productive cough, and fever of three weeks duration...
October 1, 2014: Chest
https://www.readbyqxmd.com/read/25145338/acute-respiratory-distress-syndrome-in-a-pregnant-woman-with-systemic-lupus-erythematosus-a-case-report
#17
Y-J A Chen, J-J Tseng, M-J Yang, Y-P Tsao, H-Y Lin
When the disease activity of systemic lupus erythematosus (SLE) is controlled appropriately, a pregnant woman who has lupus is able to carry safely to term and deliver a healthy infant. While the physiology of a healthy pregnancy itself influences ventilatory function, acute pulmonary distress may decrease oxygenation and influence both mother and fetus. Though respiratory failure in pregnancy is relatively rare, it remains one of the leading conditions requiring intensive care unit admission in pregnancy and carries a high risk of maternal and fetal morbidity and mortality, not to mention the complexity caused by lupus flare...
December 2014: Lupus
https://www.readbyqxmd.com/read/24605224/transplantation-of-umbilical-cord-mesenchymal-stem-cells-alleviates-pneumonitis-of-mrl-lpr-mice
#18
Yanju Zhang, Yunfei Xia, Songshi Ni, Zhifeng Gu, Hua Liu
OBJECTIVE: To investigate whether the umbilical cord mesenchymal stem cells (UC-MSCs) transplantation in the MRL/lpr mice has effect or not on their pneumonitis and the possible mechanisms underlying this treatment. METHODS: Twenty four 18-week-old MRL/lpr female mice were divided into three groups as following: the group 2 (UC-MSCT group) have been transplanted with 1×10(6) UC-MSCs through caudal vein, the group 3 (multi-UC-MSCT Group) have been transplanted with 1×10(6) UC-MSCs three times and the group 1 (control group) have been treated with 0...
February 2014: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/24383997/cyclosporin-a-therapy-for-interstitial-pneumonitis-associated-with-rheumatic-disease
#19
Y Tokano, H Ogasawara, S Ando, T Fujii, H Kaneko, N Tamura, T Yano, K Hirokawa, T Fukazawa, A Murashima, S Kobayashi, I Sekigawa, Y Takasaki, N Iida, H Hashimoto
Abstract To determine the efficacy of cyclosporin A (CysA) for the treatment of steroid-resistant interstitial pneumonitis (IP), we enrolled 25 patients with various rheumatic diseases and steroid-resistant IP in a pilot study [4 patients with rheumatoid arthritis (RA), 2 with systemic lupus erythematosus (SLE), 11 with polymyositis/dermatomyositis (PM/DM), 4 with systemic sclerosis (SSc), 1 with mixed connective tissue disease (MCTD), 3 with Sjögren syndrome (SS)]. Twelve patients (48%) showed a persistent response to CysA therapy, and 7 of them had PM/DM, including so-called amyopathic DM...
December 2002: Modern Rheumatology
https://www.readbyqxmd.com/read/24356475/acute-herpes-simplex-virus-1-pneumonitis-in-a-patient-with-systemic-lupus-erythematosus
#20
Francisca Sabugo, Ricardo Espinoza-Araya, Manuel F Meneses, Miguel Cuchacovich
A woman with severe and longstanding systemic lupus erythematosus presented with a 1-week history of fever up to 38°C and pain in her right flank. Computed tomography scan of the chest revealed interstitial infiltrates and multiple nodules. Bronchoalveolar lavage did not show any inflammatory cells. Gram stain and cultures for aerobic and anaerobic bacteria, fungi, and Nocardia; acid-fast staining; polymerase chain reaction for tuberculosis, cytomegalovirus, herpesvirus 6, and parvovirus B19; and IF staining for pneumocystic and Legionella antigen were all negative...
January 2014: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
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