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https://www.readbyqxmd.com/read/28635419/multimodal-imaging-gd-nanoparticles-functionalized-with-pittsburgh-compound-b-or-a-nanobody-for-amyloid-plaques-targeting
#1
Jonathan Pansieri, Marie Plissonneau, Nathalie Stransky-Heilkron, Mireille Dumoulin, Laurence Heinrich-Balard, Pascaline Rivory, Jean-François Morfin, Eva Toth, Maria Joao Saraiva, Eric Allémann, Olivier Tillement, Vincent Forge, François Lux, Christel Marquette
AIM: Gadolinium-based nanoparticles were functionalized with either the Pittsburgh compound B or a nanobody (B10AP) in order to create multimodal tools for an early diagnosis of amyloidoses. MATERIALS & METHODS: The ability of the functionalized nanoparticles to target amyloid fibrils made of β-amyloid peptide, amylin or Val30Met-mutated transthyretin formed in vitro or from pathological tissues was investigated by a range of spectroscopic and biophysics techniques including fluorescence microscopy...
June 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28633885/characteristics-of-paraspinal-muscle-spindle-response-to-mechanically-assisted-spinal-manipulation-a-preliminary-report
#2
William R Reed, Joel G Pickar, Randall S Sozio, Michael A K Liebschner, Joshua W Little, Maruti R Gudavalli
OBJECTIVES: The purpose of this preliminary study is to determine muscle spindle response characteristics related to the use of 2 solenoid powered clinical mechanically assisted manipulation (MAM) devices. METHODS: L6 muscle spindle afferents with receptive fields in paraspinal muscles were isolated in 6 cats. Neural recordings were made during L7 MAM thrusts using the Activator V (Activator Methods Int. Ltd., Phoenix, AZ) and/or Pulstar (Sense Technology Inc., Pittsburgh, PA) devices at their 3 lowest force settings...
June 17, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28633744/examining-the-race-specific-prevalence-of-hidradenitis-suppurativa-at-a-large-academic-center-results-from-a-retrospective-chart-review
#3
Toral Vaidya, Ramya Vangipuram, Ali Alikhan
Hidradenitis suppurativa (HS) is a chronic, inflammatory, debilitating disease of unknown etiology. HS can occur in people of all ethnicities and ages, and affects approximately 3-4% of the United States. To date, few studies have specifically examined the race prevalence of HS; further epidemiological research is needed to identify specific trends among HS and its racial predilections. At our center, 1.3% of African-American patients were seen for HS, compared to 18% of Caucasian patients (p<0.05), and the percent ratio of African-American versus Caucasian patients with HS was 7...
June 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28633472/association-between-subjective-sleep-quality-and-future-risk-of-falls-in-older-people-results-from-lohas
#4
Shiho Takada, Yosuke Yamamoto, Sayaka Shimizu, Miho Kimachi, Tatsuyoshi Ikenoue, Shingo Fukuma, Yoshihiro Onishi, Misa Takegami, Shin Yamazaki, Rei Ono, Miho Sekiguchi, Koji Otani, Shin-Ichi Kikuchi, Shin-Ichi Konno, Shunichi Fukuhara
Background: Inadequate sleep is correlated with morbidity and mortality among older adults. However, the longitudinal relationship between subjective sleep quality and risk of falls in the elderly remains to be clarified. Methods: Study participants were from Locomotive Syndrome and Health Outcome in Aizu Cohort Study (LOHAS) sites (1071 community-dwelling people ≧65 years of age, mean, 71 years). Subjective sleep quality was measured by the Pittsburgh Sleep Quality Index (PSQI)...
June 17, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28633326/the-association-between-subjective-memory-complaints-and-sleep-within-older-african-american-adults
#5
Alyssa A Gamaldo, Regina S Wright, Adrienne T Aiken-Morgan, Jason C Allaire, Roland J Thorpe, Keith E Whitfield
Objective: The purpose of the current study is to examine the association between subjective memory complaints and sleep (quantity and quality) in African American older adults. Method: Participants from the Baltimore Study of Black Aging (BSBA; n = 351; mean age = 71.99) completed a self-report sleep scale, subjective memory complaint scale, global cognitive status measure, and demographic questionnaire. Results: Worse overall sleep quality was significantly associated with subjective reports of difficulty recalling the placement of objects, recalling specific facts from reading materials, and worse memory currently compared to the past...
June 13, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28632005/sleep-problems-and-life-satisfaction-as-predictors-of-health-in-men-with-sex-chromosome-aneuploidies
#6
Krister W Fjermestad, Simen Stokke
More knowledge is needed about men with sex chromosome aneuploidies (SCA). We present self-reported data from 53 men with SCA (Mage = 36.8 years, SD = 12.3, range 19-67). The Health Survey-Short Form (SF-36) measured eight health domains (physical functioning, role-physical, role-emotional, vitality, emotional health, social functioning, pain, general health). The Pittsburgh Sleep Quality Index measured sleep problems. The Personal Wellbeing Index measured satisfaction with eight life domains. Compared to norms, SCA reported poorer health (mean d = -0...
February 21, 2017: Behavioral Medicine
https://www.readbyqxmd.com/read/28629298/anxiety-and-depression-are-improved-by-continuous-positive-airway-pressure-treatments-in-obstructive-sleep-apnea
#7
Yu-Ying Li, Thodoris Mazarakis, Yu-Chih Shen, Miao-Chun Yang, En-Ting Chang, Hsiu-Mei Wang
Background Obstructive sleep apnea involves repeated nocturnal desaturation and sleep fragmentation that leads to poor sleep quality, anxiety, and depression. This study aimed to investigate short- and long-term improvements in the anxiety and depression of patients with different obstructive sleep apnea treatments. Methods This is a prospective, non-randomized hospital-based study evaluated 55 patients (46 male, 9 female) with obstructive sleep apnea. The patients were divided into three groups based on different treatment: uvulopalatopharyngoplasty group, continuous positive airway pressure group, and no treatment group (by their own decision)...
August 2016: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/28628792/sleep-disturbances-as-predictors-of-prolonged-exposure-therapy-effectiveness-among-veterans-with-ptsd
#8
Minden B Sexton, Kimberly M Avallone, Erin R Smith, Katherine E Porter, Lisham Ashrafioun, J Todd Arnedt, Sheila A M Rauch
Sleep disturbances (SD) are pronounced in Veterans with posttraumatic stress disorder (PTSD). In clinical trials, SD have been shown to limit the effectiveness of evidence-based treatments for non-PTSD disorders. The purpose of this study was to investigate the relationships between pretreatment SD and the effectiveness of Prolonged Exposure (PE) therapy for Veterans with PTSD. Twenty-one Veterans completed the Pittsburgh Sleep Quality Index (PSQI) and the Clinician Administered PTSD Scale upon presenting to a PTSD specialty clinic...
June 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28628351/sleep-in-adolescents-and-young-adults-in-the-year-after-cancer-treatment
#9
Lauren C Daniel, Richa Aggarwal, Lisa A Schwartz
PURPOSE: Adolescents and young adults (AYA) with cancer are a vulnerable group facing more intense treatments, higher symptom burden, and poorer treatment outcomes relative to younger children. Sleep disruption is common during cancer treatment and sleep problems persist into adulthood for some survivors of AYA cancer. The developmental period of adolescence/emerging adulthood confers greater biological and behavioral risk for insufficient sleep relative to older or younger ages. Thus, understanding AYA sleep disturbances shortly after completing treatment can inform interventions to manage cancer-related symptoms and improve quality of life...
June 19, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28623402/the-impact-of-breast-cancer-treatments-on-sleep-quality-1%C3%A2-year-after-cancer-diagnosis
#10
Filipa Fontes, Susana Pereira, Ana Rute Costa, Marta Gonçalves, Nuno Lunet
PURPOSE: The increasing number of women living longer with potential side effects of breast cancer treatment highlights the need of a comprehensive assessment of its burden. Therefore, we aimed to quantify the relation between different breast cancer treatments and sleep quality 1 year after diagnosis. METHODS: A cohort of 502 newly diagnosed breast cancer patients was prospectively followed. Sleep quality was evaluated with the Pittsburgh Sleep Quality Index (PSQI), at baseline and at the 1-year follow-up...
June 16, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28623361/burden-of-sleep-disturbances-and-associated-risk-factors-a-cross-sectional-survey-among-hiv-infected-persons-on-antiretroviral-therapy-across-china
#11
Xiaojie Huang, Huiqin Li, Kathrine Meyers, Wei Xia, Zhihao Meng, Chongxi Li, Jinsong Bai, Shenghua He, Weiping Cai, Chengyu Huang, Shuiqing Liu, Hui Wang, Xuemei Ling, Ping Ma, Daling Tan, Fuxiang Wang, Lianguo Ruan, Hongxin Zhao, Hongxia Wei, Yanfen Liu, Jianhua Yu, Hongzhou Lu, Min Wang, Tong Zhang, Hui Chen, Hao Wu
This study evaluated the prevalence and factors associated with sleep disturbance in a large cohort of HIV-infected patients across China. A cross-sectional study was conducted among HIV-infected patients on antiretroviral therapy at 20 AIDS clinics. The Pittsburgh Sleep Quality Index was self-administered by subjects. Socio-demographic characteristics, medical history and HIV-related clinical data were collected. 4103 patients had complete data for analysis. Sleep disturbances were observed in 43.1% of patients...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28620064/sleep-disturbance-in-psoriatic-disease-prevalence-and-associated-factors
#12
Ian T Y Wong, Vinod Chandran, Suzanne Li, Dafna D Gladman
OBJECTIVE: We aimed to determine the prevalence and quality of sleep in patients with psoriatic arthritis (PsA) and those with psoriasis without PsA (PsC) followed in the same center, to identify factors associated with sleep disturbance, and to compare findings to those of healthy controls (HC). METHODS: The study included 113 PsA [ClASsification for Psoriatic ARthritis (CASPAR) criteria] and 62 PsC (PsA excluded by a rheumatologist) patients and 52 HC. Clinical variables were collected using a standard protocol...
June 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28619542/development-of-a-multidisciplinary-program-to-expedite-care-of-esophageal-emergencies
#13
DuyKhanh P Ceppa, Carlo Maria Rosati, Lola Chabtini, Samantha M Stokes, Holly C Cook, Karen M Rieger, Thomas J Birdas, John C Lappas, William R Kessler, John M DeWitt, Dean D Maglinte, Kenneth A Kesler
BACKGROUND: Level 1 programs have improved outcomes by expediting the multidisciplinary care of critically ill patients. We established a novel level 1 program for the management of esophageal emergencies. METHODS: After institutional review board approval, we performed a retrospective analysis of patients referred to our level 1 esophageal emergency program from April 2013 through November 2015. A historical comparison group of patients treated for the same diagnosis in the previous 2 years was used...
June 13, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28619180/are-the-insomnia-severity-index-and-pittsburgh-sleep-quality-index-valid-outcome-measures-for-cognitive-behavioral-therapy-for-insomnia-inquiry-from-the-perspective-of-response-shifts-and-longitudinal-measurement-invariance-in-their-chinese-versions
#14
Po-Yi Chen, Ya-Wen Jan, Chien-Ming Yang
OBJECTIVE: The purpose of this study was to examine whether the Insomnia Severity Index (ISI) and Pittsburgh Sleep Quality Index (PSQI) are valid outcome measures for Cognitive Behavioral Therapy for Insomnia (CBT-I). Specifically, we tested whether the factorial parameters of the ISI and the PSQI could remain invariant against CBT-I, which is a prerequisite to using their change scores as an unbiased measure of the treatment outcome of CBT-I. METHODS: A clinical data set including scores on the Chinese versions of the ISI and the PSQI obtained from 114 insomnia patients prior to and after a 6-week CBT-I program in Taiwan was analyzed...
July 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28619178/changes-in-subcortical-shape-and-cognitive-function-in-patients-with-chronic-insomnia
#15
Dae Lim Koo, Jeong-Hyeon Shin, Jae-Sung Lim, Joon-Kyung Seong, Eun Yeon Joo
OBJECTIVE: The aim of this study was to examine morphological changes in subcortical structures via surface-based analysis and to correlate local shape changes with cognitive function. METHODS: We analyzed subcortical brain morphology and compared the shape changes with clinical and neuropsychological features in patients with chronic insomnia. RESULTS: Hippocampal atrophy was associated with higher Pittsburgh Sleep Quality Index scores (r = -0...
July 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28618733/pain-depression-levels-fatigue-sleep-quality-and-quality-of-life-in-elderly-patients-with-rheumatoid-arthritis
#16
İlknur Albayrak Gezer, Ayşe Balkarli, Beray Can, Sinan Bağçaci, Sami Küçükşen, Adem Küçük
BACKGROUND/AIM: The aim of this study was to evaluate and determine the relationships (if any) among pain, depression levels, fatigue, sleep quality, and quality of life in patients with rheumatoid arthritis (RA) aged 65 years and over, and to compare the results with those of RA patients under 65 years of age. MATERIALS AND METHODS: The study included 52 patients with RA aged 65 years and over (Group 1) and 84 patients with RA under 65 years of age (Group 2). Pain, depression levels, fatigue, sleep quality, quality of life, and disease activity of all of the participants were evaluated using a visual analog scale (VAS), the Beck Depression Inventory (BDI), the Checklist Individual Strength (CIS), the Pittsburgh Sleep Quality Index (PSQI), the Short Form-36 (SF-36), and the Disease Activity Score-28, respectively...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28618721/the-relationship-between-sleep-quality-and-depressive-symptoms-in-adolescents
#17
Begüm Dağ, Fatma Yasemin Kutlu
BACKGROUND/AIM: While poor sleep quality and sleep problems are signs of depression in adolescents, depressive symptoms among this age group further deteriorate sleep quality. The aim of this study was to explore the relationship between sleep quality and depressive symptoms in adolescents of 14 to 20 years of age. MATERIALS AND METHODS: This study was conducted with a descriptive and cross-sectional research design. The sample group consisted of 313 adolescents in İstanbul, Turkey...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28616420/investigation-effect-of-oral-chamomilla-on-sleep-quality-in-elderly-people-in-isfahan-a-randomized-control-trial
#18
Mehrdad Abdullahzadeh, Pegah Matourypour, Sayed Ali Naji
BACKGROUND: Elderly people often suffer from sleep disorders. Chamomile due to the many health benefits such as sedation may be effective in improving sleep quality in elderly people. This study aimed to determine the effect of Matricaria chamomilla extract on sleep quality in elderly people admitted to nursing homes of Isfahan in 2014. MATERIALS AND METHODS: The present study is a quasi-experimental clinical trial. The study population was 77 cases of elderly hospitalized in nursing homes...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28609128/the-effect-of-different-progestogens-on-sleep-in-postmenopausal-women-a-randomized-trial
#19
Ekachai Leeaunkulsathean, Tawiwan Pantasri, Somsak Chaovisitseree, Nuntana Morakot
BACKGROUND: While progesterone affects sleep, different types of it might affect sleep differently. METHODS: One hundred Thai women, who complained of insomnia, visited the Menopause Clinic at Maharaj Nakorn Chiang Mai Hospital, Chiang Mai, Thailand from February 2014 to March 2015, and were divided randomly into two groups. Both groups received daily hormonal treatment that included estradiol valerate (progynova) at 1 mg. The first group also received dydrogesterone (duphaston(®)) at 10 mg and the second group micronized progesterone (utrogestran(®)) at 100 mg...
June 13, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28605642/applicability-of-11-c-pib-micro-pet-imaging-for-in%C3%A2-vivo-follow-up-of-anti-amyloid-treatment-effects-in-app23-mouse-model
#20
Anniina Snellman, Johanna Rokka, Francisco R López-Picón, Semi Helin, Francesca Re, Eliisa Löyttyniemi, Rea Pihlaja, Gianluigi Forloni, Mario Salmona, Massimo Masserini, Olof Solin, Juha O Rinne, Merja Haaparanta-Solin
In this study, we evaluated the anti-amyloid effect of functionalized nanoliposomes (mApoE-PA-LIP) in a mouse model of Alzheimer's disease with use of positron emission tomography and β-amyloid (Aβ)-targeted tracer [(11)C]Pittsburgh compound B ([(11)C]PIB). APP23 mice were injected with mApoE-PA-LIP or saline (3 times per week for 3 weeks) and [(11)C]PIB imaging was performed at baseline, after the treatment and after 3 months follow-up period, accompanied by Aβ immunohistochemistry and ELISA. After the treatment, [(11)C]PIB binding ratios between mApoE-PA-LIP and saline groups were equivalent in all analyzed brain regions; however, in the saline group, binding ratios increased from the baseline, whereas no increase was detected in the mApoE-PA-LIP group...
May 15, 2017: Neurobiology of Aging
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