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Stroke mimics

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https://www.readbyqxmd.com/read/29331614/the-burden-of-stroke-mimics-present-and-future-projections
#1
Kashif Waqar Faiz, Angela Susan Labberton, Bente Thommessen, Ole Morten Rønning, Fredrik A Dahl, Mathias Barra
BACKGROUND AND PURPOSE: An increasing proportion of patients presenting with suspected stroke prove to have other conditions, often referred to as stroke mimics. The aim of this study was to present a projection of the number of hospitalized strokes, transient ischemic attacks (TIAs), and stroke mimics in Norway up to the year 2050 based on expected demographic changes, to estimate the burden of stroke mimics in the coming decades. MATERIALS AND METHODS: This prospective study included all admissions to the stroke unit of Akershus University Hospital from March 1, 2012, to February 28, 2013...
January 10, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29317607/mirna-3473b-contributes-to-neuroinflammation-following-cerebral-ischemia
#2
Xiaoyu Wang, Shuangshuang Chen, Jingshu Ni, Jian Cheng, Jia Jia, Xuechu Zhen
MicroRNAs play an essential role in stroke pathology. Here, we investigated the role of a newly identified microRNA, miR-3473b, in stroke pathology. The expression of miR-3473b was upregulated in the cortex and striatum in mice following transient middle cerebral artery occlusion (MCAO). Intracerebroventricular injection of the miR-3473b antagomir prior to MCAO remarkably attenuated ischemia-induced expression of miR-3473b and pro-inflammatory factors in the ischemic brain and decreased infarct volumes in mice following MCAO...
January 9, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29306185/pre-stroke-employment-results-in-better-patient-reported-outcomes-after-minor-stroke-short-title-functional-outcomes-after-minor-stroke
#3
Elisabeth B Marsh, Erin Lawrence, Argye E Hillis, Karen Chen, Rebecca F Gottesman, Rafael H Llinas
OBJECTIVE: Individuals with "minor stroke" lack a dense hemiparesis or aphasia; however, commonly endorse persistent cognitive and motor problems despite low NIHSS scores. They also report problems with mood, energy, and the ability to think clearly that are less well characterized. Socioeconomic factors and stroke severity can influence patient-reported outcomes. In this study we explore patient-reported outcomes and the influence of these factors after minor stroke. PATIENTS AND METHODS: Patients returning to clinic post-stroke with an NIHSS of ≤ 4 were administered a scale to quantify problems with daily activities and resulting functional burden, along with measures of fatigue and depression...
December 27, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29303438/prospective-randomized-blinded-and-placebo-controlled-study-of-cerebrolysin-dose-response-effects-on-long-term-functional-outcomes-in-a-rat-model-of-mild-traumatic-brain-injury
#4
Yanlu Zhang, Michael Chopp, Zheng Gang Zhang, Yi Zhang, Li Zhang, Mei Lu, Talan Zhang, Stefan Winter, Hemma Brandstätter, Asim Mahmood, Ye Xiong
OBJECTIVE Cerebrolysin is a neuropeptide preparation that mimics the properties of neurotrophic factors and has had beneficial effects in the treatment of neurodegenerative diseases, stroke, and traumatic brain injury (TBI). To further evaluate treatment schemes, the authors assessed the dose-response of Cerebrolysin on functional improvement in a rat model of mild TBI (mTBI). METHODS This dose-response study was a prospective, randomized, blinded, and placebo-controlled preclinical experiment. Male Wistar adult rats, subjected to mTBI induced by a closed head impact, were treated randomly with 0 (saline as placebo), 0...
January 5, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29295509/endocrine-disrupting-chemicals-mediated-through-binding-androgen-receptor-are-associated-with-diabetes-mellitus
#5
REVIEW
Sugunadevi Sakkiah, Tony Wang, Wen Zou, Yuping Wang, Bohu Pan, Weida Tong, Huixiao Hong
Endocrine disrupting chemicals (EDCs) can mimic natural hormone to interact with receptors in the endocrine system and thus disrupt the functions of the endocrine system, raising concerns on the public health. In addition to disruption of the endocrine system, some EDCs have been found associated with many diseases such as breast cancer, prostate cancer, infertility, asthma, stroke, Alzheimer's disease, obesity, and diabetes mellitus. EDCs that binding androgen receptor have been reported associated with diabetes mellitus in in vitro, animal, and clinical studies...
December 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29291393/patchouli-alcohol-protects-against-ischemia-reperfusion-induced-brain-injury-via-inhibiting-neuroinflammation-in-normal-and-obese-mice
#6
Li-Li Wei, Yong Chen, Qiong-Yang Yu, Yuhui Wang, George Liu
Almost all of the candidate drugs for ischemic stroke failed to be translated from bench to beside. One important reason is that animals used in experimental studies cannot mimic ischemic patients due to lack of comorbidities like hypertension, diabetes and obesity. Therefore, it is better to test candidate drugs not only in normal animals but also in animals with comorbidities. Patchouli alcohol (PA), a natural tricyclic sesquiterpene in the traditional Chinese herb Pogostemonisherba, is well recognized for its anti-inflammation function in various inflammatory diseases...
December 29, 2017: Brain Research
https://www.readbyqxmd.com/read/29290532/thrombolysis-alert-in-hassan-ii-university-teaching-hospital-of-fez-morocco-a-prospective-study-of-2-years
#7
Moussa Toudou Daouda, Siham Bouchal, Naima Chtaou, Aouatef Midaoui, Zouahyr Souirti, Faouzi Belahsen
BACKGROUND: Thrombolysis alert (TA) is a procedure triggered every time a patient consults for sudden focal neurological deficit within 4.5 hours. OBJECTIVE: We aimed to determine firstly the etiological profile of TA and secondly to evaluate the delays in the management not only of thrombolyzed patients but also of nonthrombolyzed patients to determine the intrahospital delays to optimize. METHODS: Patients aged over 18 years who consulted for sudden focal neurological deficit within 4...
December 29, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29277912/a-hemorrhagic-transformation-model-of-mechanical-stroke-therapy-with-acute-hyperglycemia-in-mice
#8
David Couret, Steeve Bourane, Aurélie Catan, Brice Nativel, Cynthia Planesse, Anne-Claire Dorsemans, Imade Ait-Arsa, Maxime Cournot, Philippe Rondeau, Jessica Patche, Alexy Tran-Dinh, Gilles Lambert, Nicolas Diotel, Olivier Meilhac
Clinical benefit for mechanical thrombectomy (MT) in stroke was recently demonstrated in multiple large prospective studies. Acute hyperglycemia is an important risk factor of poor outcome in stroke patients, including those that underwent MT. The aim of this therapy is to achieve a complete reperfusion in a short time, given that reperfusion damage is dependent on the duration of ischemia. Here, we investigated the effects of acute hyperglycemia in a mouse model of ischemic stroke induced by middle cerebral artery occlusion (MCAO)...
December 26, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29276566/methotrexate-induced-neurotoxicity-an-uncommon-stroke-mimic
#9
J David Avila
No abstract text is available yet for this article.
January 2018: Neurohospitalist
https://www.readbyqxmd.com/read/29276559/door-to-needle-time-in-acute-stroke-treatment-and-the-july-effect
#10
Maximiliano A Hawkes, Federico Carpani, Mauricio F Farez, Sebastian F Ameriso
Intravenous thrombolysis improves outcomes in acute ischemic stroke in a time-dependent fashion. As in teaching hospitals, clinical outcomes may worsen due to the arrival of new inexperienced house staff early in the academic year (July effect, JE), we evaluated the impact of the "JE" on the door-to-needle time for intravenous thrombolysis and other stroke outcomes. In this retrospective cohort study, we assessed all acute ischemic strokes treated with intravenous thrombolysis between July 2003 and June 2016...
January 2018: Neurohospitalist
https://www.readbyqxmd.com/read/29273597/intravenous-thrombolysis-for-stroke-and-presumed-stroke-in-human-immunodeficiency-virus-infected-adults-a-retrospective-multicenter-us-study
#11
Mahmoud A AbdelRazek, Jose Gutierrez, David Mampre, Anna Cervantes-Arslanian, Cora Ormseth, Diogo Haussen, Kiran T Thakur, Jennifer L Lyons, Bryan R Smith, Owen O'Connor, Joshua Z Willey, Farrah J Mateen
BACKGROUND AND PURPOSE: Human immunodeficiency virus (HIV) infection has been shown to increase both ischemic and hemorrhagic stroke risks, but there are limited data on the safety and outcomes of intravenous thrombolysis with tPA (tissue-type plasminogen activator) for acute ischemic stroke in HIV-infected patients. METHODS: A retrospective chart review of intravenous tPA-treated HIV patients who presented with acute stroke symptoms was performed in 7 large inner-city US academic centers (various search years between 2000 and 2017)...
January 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29258866/suppression-of-nlrp3-attenuates-hemorrhagic-transformation-after-delayed-rtpa-treatment-in-thromboembolic-stroke-rats-involvement-of-neutrophil-recruitment
#12
Zhiliang Guo, Shuhong Yu, Xin Chen, Ping Zheng, Ting Hu, Zhenhui Duan, Xiaoyun Liu, Qian Liu, Ruidong Ye, Wusheng Zhu, Xinfeng Liu
BACKGROUND: Inflammation and neutrophils play pivotal roles in hemorrhagic transformation (HT) after recombinant tissue plasminogen activator (rtPA) treatment in stroke; however, the contribution of Nod-like receptor protein 3 (NLRP3), a key component of the innate immune system, is not yet known. This study aimed to explore the role of NLRP3 in the delayed rtPA-induced HT and its association with the neutrophil recruitment. METHODS: Rats were subjected to thromboembolic focal cerebral ischemia and delayed rtPA treatment at 4 h after ischemia to mimic HT...
December 16, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29228907/secondary-pallidonigral-degeneration-mimicking-recurrent-acute-stroke-in-clinical-presentation-and-magnetic-resonance-imaging-a-case-report
#13
Ruei-Je Tsai, Li-Chun Hsieh, Sho-Jen Cheng, Cheng-Yu Chen
BACKGROUND: Secondary pallidonigral transneuronal degeneration after a remote primary cerebral infarct can mimic recurrent stroke at clinical presentation. We describe a patient with secondary pallidonigral degeneration following a previous putaminal infarct, which was diagnosed through diffusion-weighted (DWI) and T2-weighted imaging (T2WI). CASE PRESENTATION: A 64-year-old man complained of an acute relapse of right-lower-limb weakness following a cerebral infarction 2 months before presentation...
December 11, 2017: BMC Neurology
https://www.readbyqxmd.com/read/29222799/middle-cerebral-artery-occlusion-by-an-intraluminal-suture-method
#14
Rosalia Crupi, Rosanna Di Paola, Emanuela Esposito, Salvatore Cuzzocrea
Stroke represents the most common fatal neurological disease especially in highly developed countries. Even today, treatment options are very limited. The development of new therapeutic approaches replies, to a great extent, on experimental rodent models of focal cerebral ischemia. Since ~80% of ischemic strokes occur in the area of middle cerebral artery (MCA), a number of these stroke models are based on this artery. The intraluminal monofilament model of MCA occlusion involves the insertion of a surgical filament inside the external carotid artery and its extension into the internal carotid artery until the tip occludes the source of the MCA-thus arresting blood flow with resultant infarction in the MCA area...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29218615/advanced-ct-for-diagnosis-of-seizure-related-stroke-mimics
#15
Friederike Austein, Monika Huhndorf, Johannes Meyne, Helmut Laufs, Olav Jansen, Thomas Lindner
BACKGROUND AND PURPOSE: It is assumed that up to 30 % of clinically diagnosed acute ischaemic strokes (AIS) are actually stroke mimics (SM). Our aim was to evaluate the usefulness of advanced CT including CT angiography (CTA) and CT perfusion (CTP) findings when distinguishing AIS from seizure-related SM. METHODS: Over a 22-month period data were gathered of patients who presented to our stroke centre with AIS-like symptoms and were examined immediately with an advanced CT, analysed and evaluated by two experienced neuroradiologists who preferred SM rather than AIS...
December 7, 2017: European Radiology
https://www.readbyqxmd.com/read/29212096/-stroke-mimics-and-stroke-chameleons-differential-diagnosis-of-stroke
#16
Frank Erbguth
The analysis of misdiagnosis of stroke has become increasingly relevant because of the time pressure in the thrombolytic treatment of ischemic strokes. Within the narrow time window of thrombolysis, a false-positive stroke diagnosis can lead to a faulty and potentially dangerous thrombolysis. The terms "Stroke Mimic" (SM = false-positive stroke diagnosis) and "Stroke Chameleon" (SC = false-negative stroke diagnosis) have been introduced for misdiagnosis in this field. The rate of SM decreases during the treatment phases from approximately 50 % in the preclinical situation to approximately 2-10 % in the Stroke Unit indicating thrombolytic therapy...
December 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/29211360/cerebral-venous-thrombosis-as-a-diagnostic-challenge-clinical-and-radiological-correlation-based-on-the-retrospective-analysis-of-own-cases
#17
Anna Zimny, Edyta Dziadkowiak, Joanna Bladowska, Justyna Chojdak-Łukasiewicz, Aleksandra Loster-Niewińska, Marek Sąsiadek, Bogusław Paradowski
BACKGROUND: Cerebral venous thrombosis (CVT) is a rare condition which constitutes 0.5-1% of all strokes. The clinical and radiological picture of CVT is non-specific and can mimic other disorders. OBJECTIVES: The aim of the study was to retrospectively evaluate and correlate clinical and radiological symptoms presented by patients with CVT, both in the initial and follow-up neurological and neuroimaging examinations, with a special emphasis on diagnostic difficulties...
October 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29206299/microrna-137-promotes-endothelial-progenitor-cell-proliferation-and-angiogenesis-in-cerebral-ischemic-stroke-mice-by-targeting-nr4a2-through-the-notch-pathway
#18
Xing-Li Liu, Gang Wang, Wei Song, Wei-Xin Yang, Jian Hua, Liang Lyu
Cerebral ischemic stroke (CIS) is one of the common causes of death and disability worldwide. This study aims to investigate effect of miR-137 on endothelial progenitor cells and angiogenesis in CIS by targeting NR4A2 via the Notch pathway. Brain tissues were extracted from CIS and normal mice. Immunohistochemistry was used to determine positive rate of NR4A2 expression. Serum VEGF, Ang, HGF and IκBα levels were determined by ELISA. RT-qPCR and western blotting were used to determine expression of related factors...
December 5, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29202795/validation-of-an-algorithm-that-determines-stroke-diagnostic-code-accuracy-in-a-japanese-hospital-based-cancer-registry-using-electronic-medical-records
#19
Yasufumi Gon, Daijiro Kabata, Keichi Yamamoto, Ayumi Shintani, Kenichi Todo, Hideki Mochizuki, Manabu Sakaguchi
BACKGROUND: This study aimed to validate an algorithm that determines stroke diagnostic code accuracy, in a hospital-based cancer registry, using electronic medical records (EMRs) in Japan. METHODS: The subjects were 27,932 patients enrolled in the hospital-based cancer registry of Osaka University Hospital, between January 1, 2007 and December 31, 2015. The ICD-10 (international classification of diseases, 10th revision) diagnostic codes for stroke were extracted from the EMR database...
December 4, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29196198/neurosurgical-modeling-of-retinal-ischemia-reperfusion-injury
#20
Alireza P Shabanzadeh, Philippe M D'Onofrio, Philippe P Monnier, Paulo D Koeberle
BACKGROUND: A reliable model of ischemia-reperfusion is required to evaluate the efficacy and safety of neuroprotective therapies for stroke. We present a novel reproducible pterygopalatine-ophthalmic artery ligation model of ischemia-reperfusion injury in the retina. METHODS: Rats were subjected to ophthalmic artery/meningeal sheath ligation (OAML-standard method) or clamping of the pterygopalatine-ophthalmic artery (OAC-new method) for 30 minutes. Retinal ganglion cell (RGC) survival was assessed by prelabeling with FluoroGold (FG) (Santa Cruz Biotechnology, CA, USA) and RNA-binding protein with multiple splicing (RBPMS) at 14 days after ischemia, and all results were compared with a sham group (n = 7 in each group)...
November 29, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
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