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https://www.readbyqxmd.com/read/29452273/3d-bioprinted-functional-and-contractile-cardiac-tissue-constructs
#1
Zhan Wang, Sang Jin Lee, Heng-Jie Cheng, James J Yoo, Anthony Atala
Bioengineering of a functional cardiac tissue composed of primary cardiomyocytes has great potential for myocardial regeneration and in vitro tissue modeling. However, its applications remain limited because the cardiac tissue is a highly organized structure with unique physiologic, biomechanical, and electrical properties. In this study, we undertook a proof-of-concept study to develop a contractile cardiac tissue with cellular organization, uniformity, and scalability by using three-dimensional (3D) bioprinting strategy...
February 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29451572/3d-printed-scaffolds-with-gradient-porosity-based-on-a-cellulose-nanocrystal-hydrogel
#2
Sahar Sultan, Aji P Mathew
3-Dimensional (3D) printing provides a unique methodology for the customization of biomedical scaffolds with respect to size, shape, pore structure and pore orientation useful for tissue repair and regeneration. 3D printing was used to fabricate fully bio-based porous scaffolds of a double crosslinked interpenetrating polymer network (IPN) from a hydrogel ink of sodium alginate and gelatin (SA/G) reinforced with cellulose nanocrystals (CNCs). CNCs provided favorable rheological properties required for 3D printing...
February 16, 2018: Nanoscale
https://www.readbyqxmd.com/read/29451446/improving-patient-safety-during-introduction-of-novel-medical-devices-through-cumulative-summation-analysis
#3
Vejay N Vakharia, Roman Rodionov, Andrew W McEvoy, Anna Miserocchi, Rachel Sparks, Aidan G O'Keeffe, Sebastien Ourselin, John S Duncan
OBJECTIVE The aim of this study was to implement cumulative summation (CUSUM) analysis as an early-warning detection and quality assurance system for preclinical testing of the iSYS1 novel robotic trajectory guidance system. METHODS Anatomically accurate 3D-printed skull phantoms were created for 3 patients who underwent implantation of 21 stereoelectroencephalography electrodes by surgeons using the current standard of care (frameless technique). Implantation schema were recreated using the iSYS1 system, and paired accuracy measures were compared with the previous frameless implantations...
February 16, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29450886/theoretical-and-experimental-determination-of-scaling-factors-in-electron-dosimetry-for-3d-printed-polylactic-acid
#4
Stefanos Diamantopoulos, Ioannis Kantemiris, Georgios Patatoukas, Maria Dilvoi, Efstathios Efstathopoulos, Vassilis Kouloulias, Kalliopi Platoni
PURPOSE: Plastic phantoms are commonly used in daily routine for dosimetric tasks in radiation therapy. Despite the fact that water is the reference medium according to the dosimetric protocols, measurements with non-water phantoms are easier to be performed. To succeed absorbed dose determination, certain scaling factors have to be applied to the acquired measurements. Taking into account the increased availability of three-dimensional (3D) printing, we attempted to obtain scaling factors for polylactic acid (PLA), a commonly used thermoplastic material for 3D printing...
February 16, 2018: Medical Physics
https://www.readbyqxmd.com/read/29449282/a-patient-dose-reduction-technique-for-neuroendovascular-image-guided-interventions-image-quality-comparison-study
#5
A Sonig, S V Setlur Nagesh, V S Fennell, S Gandhi, L Rangel-Castilla, C N Ionita, K V Snyder, L N Hopkins, D R Bednarek, S Rudin, A H Siddiqui, E I Levy
BACKGROUND AND PURPOSE: The ROI-dose-reduced intervention technique represents an extension of ROI fluoroscopy combining x-ray entrance skin dose reduction with spatially different recursive temporal filtering to reduce excessive image noise in the dose-reduced periphery in real-time. The aim of our study was to compare the image quality of simulated neurointerventions with regular and reduced radiation doses using a standard flat panel detector system. MATERIALS AND METHODS: Ten 3D-printed intracranial aneurysm models were generated on the basis of a single patient vasculature derived from intracranial DSA and CTA...
February 15, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29448707/surface-roughness-of-a-3d-printed-ni-cr-alloy-produced-by-selective-laser-melting-effect-of-process-parameters
#6
Min-Ho Hong, Jun Sik Son, Tae-Yub Kwon
The selective laser melting (SLM) process parameters, which directly determine the melting behavior of the metallic powders, greatly affect the nanostructure and surface roughness of the resulting 3D object. This study investigated the effect of various laser process parameters (laser power, scan rate, and scan line spacing) on the surface roughness of a nickel-chromium (Ni-Cr) alloy that was three-dimensionally (3D) constructed using SLM. Single-line formation tests were used to determine the optimal laser power of 200 W and scan rate of 98...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29447855/rpa-using-a-multiplexed-cartridge-for-low-cost-point-of-care-diagnostics-in-the-field
#7
Luck Tosan Ereku, Ruth E Mackay, Pascal Craw, Angel Naveenathayalan, Thomas Stead, Manorharanehru Branavan, Wamadeva Balachandran
A point of care device utilising Lab-on-a-Chip technologies that is applicable for biological pathogens was designed, fabricated and tested showing sample in to answer out capabilities. The purpose of the design was to develop a cartridge with the capability to perform nucleic acid extraction and purification from a sample using a chitosan membrane at an acidic pH. Waste was stored within the cartridge with the use of sodium polyacrylate to solidify or gelate the sample in a single chamber. Nucleic acid elution was conducted using the RPA amplification reagents (alkaline pH)...
February 12, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29447126/impact-of-orientation-on-dimensional-accuracy-of-3d-printed-orthodontic-models
#8
Megan M Short, Christian S Favero, Jeryl D English, F Kurtis Kasper
No abstract text is available yet for this article.
January 2018: Journal of Clinical Orthodontics: JCO
https://www.readbyqxmd.com/read/29446982/development-of-an-omentum-cultured-oesophageal-scaffold-reinforced-by-a-3d-printed-ring-feasibility-of-an-in-vivo-bioreactor
#9
Eun-Jae Chung, Hyung Woo Ju, Yeung Kyu Yeon, Ji Seung Lee, Young Jin Lee, Ye Been Seo, Park Chan Hum
Current treatments of oesophageal diseases, such as carcinoma, congenital abnormality or trauma, require surgical intervention and oesophageal reconstruction with the stomach, jejunum or colon. However, serious side effects are possible with each treatment option. Despite tissue engineering promising to be an effective regenerative strategy, no functional solution currently exists for oesophageal reconstruction. Here, we developed an omentum-cultured oesophageal scaffold reinforced by a 3D-printed ring. The nano-structured scaffolds were wrapped into the omentum of rats and orthotopically transplanted for the repair of circumferential oesophageal defects two weeks later...
February 15, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29446761/3d-printed-stretchable-capacitive-sensors-for-highly-sensitive-tactile-and-electrochemical-sensing
#10
Kai Li, Hong Wei, Wenguang Liu, Hong Meng, Peixin Zhang, Chaoyi Yan
Developments of innovative strategies for the fabrication of stretchable sensors are of crucial importance for their applications in wearable electronic systems. In this work, we report the successful fabrication of stretchable capacitive sensors using a novel 3D printing method for highly sensitive tactile and electrochemical sensing applications. Unlike conventional lithographic or templated methods, the programmable 3D printing technique can fabricate complex device structures in a cost-effective and facile manner...
February 15, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29446757/3d-bioprinting-mesenchymal-stem-cell-laden-construct-with-core-shell-nanospheres-for-cartilage-tissue-engineering
#11
Wei Zhu, Haitao Cui, Benchaa Boualam, Fahed Masood, Erin Flynn, Raj Rao, Zhiyong Zhang, Lijie Grace Zhang
Cartilage tissue is prone to degradation and has little capacity for self-healing due to its avascularity. Tissue engineering, which provides artificial scaffolds to repair injured tissues, is a novel and promising strategy for cartilage repair. 3D bioprinting offers even greater potential for repairing degenerative tissue by simultaneously integrating living cells, biomaterials, and biological cues to provide a customized scaffold. With regard to cell selection, mesenchymal stem cells (MSCs) hold great capacity for differentiating into a variety of cell types, including chondrocytes, and could therefore be utilized as a cartilage cell source in 3D bioprinting...
February 15, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29446490/a-3-dimensional-printed-patient-specific-guide-system-for-minimally-invasive-plate-osteosynthesis-of-a-comminuted-mid-diaphyseal-humeral-fracture-in-a-cat
#12
Bill Oxley
OBJECTIVE: To report the use of a 3-dimensional (3D)-printed patient-specific reduction guide system to facilitate minimally invasive plate osteosynthesis (MIPO) of a humeral fracture in a cat. STUDY DESIGN: Case report. ANIMALS: A 9-year-old male neutered domestic short hair cat weighing 4.4 kg. METHODS: A 9-year-old male domestic short hair cat was presented with a comminuted, mid-diaphyseal left humeral fracture. Computed tomographic data were processed to yield 3D mesh representations of both humeri and subsequently manipulated in computer-aided design software...
February 15, 2018: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29445972/design-and-validation-of-an-osteochondral-bioreactor-for-the-screening-of-treatments-for-osteoarthritis
#13
Derek A Nichols, Inderbir S Sondh, Steven R Litte, Paolo Zunino, Riccardo Gottardi
Bioreactors are systems that can be used to monitor the response of tissues and cells to candidate drugs. Building on the experience developed in the creation of an osteochondral bioreactor, we have designed a new 3D printed system, which allows optical access to the cells throughout testing for in line monitoring. Because of the use of 3D printing, the fluidics could be developed in the third dimension, thus maintaining the footprint of a single well of a typical 96 well plate. This new design was optimized to achieve the maximum fluid transport through the central chamber, which corresponds to optimal nutrient or drug exposure...
February 14, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29445790/green-polymerizable-deep-eutectic-solvent-pdes-type-conductive-paper-for-origami-3d-circuits
#14
Li Ren'ai, Kaili Zhang, Guangxue Chen, Bin Su, Junfei Tian, Minghui He, Fachuang Lu
We report a green fabrication of conductive paper based on in situ polymerization of polymerizable deep eutectic solvents (PDESs) through a screen printing process. By pre-designed circuit paths and careful integration, on-demand input/output 3D circuits can be achieved, showing its flexibility to origami electronics.
February 15, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29445303/uncemented-three-dimensional-printed-prosthetic-replacement-for-giant-cell-tumor-of-distal-radius-a-new-design-of-prosthesis-and-surgical-techniques
#15
Minxun Lu, Li Min, Cong Xiao, Yongjiang Li, Yi Luo, Yong Zhou, Wenli Zhang, Chongqi Tu
Introduction: Currently, it is challenging to treat giant cell tumor (GCT) of distal radius. For Campanacci grade III or recurrent GCTs, en bloc resection has been accepted as a better treatment option. Although numerous methods are available for reconstruction, all of them have some limitations in joint function and complications. In this study, our aims were to treat the GCT of distal radius with uncemented three-dimensional (3D)-printed prosthesis and to present and evaluate the surgical techniques and short-term outcomes...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29443890/embedded-disposable-functionalized-electrochemical-biosensor-with-a-3d-printed-flow-cell-for-detection-of-hepatic-oval-cells-hocs
#16
Samar Damiati, Martin Peacock, Stefan Leonhardt, Laila Damiati, Mohammed A Baghdadi, Holger Becker, Rimantas Kodzius, Bernhard Schuster
Hepatic oval cells (HOCs) are considered the progeny of the intrahepatic stem cells that are found in a small population in the liver after hepatocyte proliferation is inhibited. Due to their small number, isolation and capture of these cells constitute a challenging task for immunosensor technology. This work describes the development of a 3D-printed continuous flow system and exploits disposable screen-printed electrodes for the rapid detection of HOCs that over-express the OV6 marker on their membrane. Multiwall carbon nanotube (MWCNT) electrodes have a chitosan film that serves as a scaffold for the immobilization of oval cell marker antibodies (anti-OV6-Ab), which enhance the sensitivity of the biomarker and makes the designed sensor specific for oval cells...
February 14, 2018: Genes
https://www.readbyqxmd.com/read/29442788/hydroxyapatite-nanoparticle-coated-3d-printed-porous-ti6al4v-and-cocrmo-alloy-scaffolds-and-their-biocompatibility-to-human-osteoblasts
#17
Wei Yuan, Xin He, Xiaoshu Zhou, Yue Zhu
Hydroxyapatite nanoparticles were prepared by hydrothermal method using calcium nitrate and phosphoric acid as precursors and ammonia aqueous solution as a pH value adjustor. The 3D-printed porous Ti6Al4V and CoCrMo alloy scaffolds were effectively coated with hydroxyapatite nanoparticles in the hydrothermal synthesis process by deposition method. Coating hydroxyapatite nanoparticles on the implant surfaces increased their biocompatibility and bioactivity. HAP-deposited Ti6Al4V or HAP-deposited CoCrMo scaffold induced no statistical increase in terms of apoptosis in hFOB1...
June 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29441429/three-dimensional-printing-improves-osteochondral-allograft-placement-in-complex-cases
#18
Kelechi R Okoroha, Timothy J Evans, Jeffrey P Stephens, Eric C Makhni, Vasilios Moutzouros
The use of three-dimensional (3D) printing has seen a vast expansion over recent years, with an increased application for its use in orthopaedics. This report details the use of 3D printing technology to aid in the treatment of a medial femoral condyle osteochondral defect in a 26-year-old female who had previously undergone a failed autograft procedure. A preoperative computed tomography scan of the knee and chondral defect was used to generate a 3D printed, one-to-one scale replica of the distal femur. This replica was then used to size a patient-specific allograft plug for the osteochondral transplantation procedure...
February 13, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29440763/rhythm-an-open-source-imaging-toolkit-for-cardiac-panoramic-optical-mapping
#19
Christopher Gloschat, Kedar Aras, Shubham Gupta, N Rokhaya Faye, Hanyu Zhang, Roman A Syunyaev, Roman A Pryamonosov, Jack Rogers, Matthew W Kay, Igor R Efimov
Fluorescence optical imaging techniques have revolutionized the field of cardiac electrophysiology and advanced our understanding of complex electrical activities such as arrhythmias. However, traditional monocular optical mapping systems, despite having high spatial resolution, are restricted to a two-dimensional (2D) field of view. Consequently, tracking complex three-dimensional (3D) electrical waves such as during ventricular fibrillation is challenging as the waves rapidly move in and out of the field of view...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29439905/three-dimensional-intracranial-middle-cerebral-artery-aneurysm-models-for-aneurysm-surgery-and-training
#20
Liang Wang, Xun Ye, Qiang Hao, Li Ma, Xiaolin Chen, Hao Wang, Yuanli Zhao
To develop a realistic model of middle cerebral artery (MCA) aneurysms using three-dimensional (3D) printing for surgical planning, research, and training of neurosurgical residents. This study included eight MCA aneurysm cases. The aneurysm together with the adjacent arteries and skull base were printed based on raw computed tomography angiography (CTA) data using a 3D printer with acrylonitrile-butadiene-styrene as the model material. The aneurysm models were used for surgical planning, and craniotomy and clipping practice by neurosurgical residents...
February 10, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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