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https://www.readbyqxmd.com/read/28800764/lrp-a-global-regulator-regulates-the-virulence-of-vibrio-vulnificus
#1
Yu-Chi Ho, Feng-Ru Hung, Chao-Hui Weng, Wei-Ting Li, Tzu-Hung Chuang, Tsung-Lin Liu, Ching-Yuan Lin, Chien-Jung Lo, Chun-Liang Chen, Jen-Wei Chen, Masayuki Hashimoto, Lien-I Hor
BACKGROUND: An attenuated mutant (designated NY303) of Vibrio vulnificus, which causes serious wound infection and septicemia in humans, was isolated fortuitously from a clinical strain YJ016. This mutant was defective in cytotoxicity, migration on soft agar and virulence in the mouse. The purpose of this study was to map the mutation in this attenuated mutant and further explore how the gene thus identified is involved in virulence. METHODS: The whole genome sequence of mutant NY303 determined by next-generation sequencing was compared with that of strain YJ016 to map the mutations...
August 11, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28781188/distribution-and-antimicrobial-susceptibility-of-vibrio-species-associated-with-zooplankton-in-coastal-area-of-korea
#2
Ji Hye Yang, Jong Soo Mok, Yeoun Joong Jung, Ka Jeong Lee, Ji Young Kwon, Kunbawui Park, Seong Yong Moon, Soon Jae Kwon, A Ra Ryu, Tea Seek Lee
Vibrio parahaemolyticus and V. vulnificus are the most common pathogens causing seafood-borne illnesses in Korea. This study determines the abundance and antimicrobial resistance of pathogenic Vibrio species in seawater and zooplankton samples from the Geoje Island coast in Korea, which is an important area for coastal fisheries, the fishing industry, and tourism. The two Vibrio species were detected more in mesozooplankton samples than in seawater samples. V. parahaemolyticus isolates showed greater resistance than those of V...
August 4, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28719654/vibrio-vulnificus-induces-mtor-activation-and-inflammatory-responses-in-macrophages
#3
Dan-Li Xie, Meng-Meng Zheng, Yi Zheng, Hui Gao, Jie Zhang, Ting Zhang, Jian-Chun Guo, X Frank Yang, Xiao-Ping Zhong, Yong-Liang Lou
Vibrio vulnificus (V. vulnificus), a Gram-negative marine bacterium, can cause life-threatening primary septicemia, especially in patients with liver diseases. How V. vulnificus affects the liver and how it acts on macrophages are not well understood. In this report, we demonstrated that V. vulnificus infection causes a strong inflammatory response, marked expansion of liver-resident macrophages, and liver damage in mice. We demonstrated further that V. vulnificus activates mTOR in macrophages and inhibition of mTOR differentially regulates V...
2017: PloS One
https://www.readbyqxmd.com/read/28719320/skin-manifestations-of-primary-vibrio-vulnificus-septicemia
#4
Norman L Beatty, Jose Marquez, Mayar Al Mohajer
No abstract text is available yet for this article.
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28704687/antimicrobial-polyketide-furanoterpenoids-from-seaweed-associated-heterotrophic-bacterium-bacillus-subtilis-mtcc-10403
#5
Kajal Chakraborty, Bini Thilakan, Vamshi Krishna Raola
Brown seaweed Anthophycus longifolius (Turner) Kützing (family Sargassaceae) associated heterotrophic bacterium Bacillus subtilis MTCC 10403 was found to be a potent isolate with broad range of antibacterial activity against important perceptive food pathogens Vibrio parahaemolyticus, V. vulnificus, and Aeromonas hydrophila. This bacterium was positive for polyketide synthetase gene (KC589397), and therefore, was selected to bioprospect specialized metabolites bearing polyketide backbone. Bioactivity-guided chromatographic fractionation of the ethyl acetate extract of the seaweed-associated bacterium segregated four homologous polyketide furanoterpenoids with potential antibacterial activities against clinically important pathogens...
July 10, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28696147/effects-of-desiccation-practices-of-cultured-atlantic-oysters-crassostrea-virginica-on-vibrio-spp-in-portersville-bay-alabama-usa
#6
Stephanie M Grodeska, Jessica L Jones, Covadonga R Arias, William C Walton
The expansion of off-bottom aquaculture to the Gulf of Mexico has raised public health concerns for human health officials. High temperatures in the Gulf of Mexico are associated with high levels of Vibrio parahaemolyticus and Vibrio vulnificus. Routine desiccation practices associated with off-bottom aquaculture expose oysters to ambient air, allowing Vibrio spp. to proliferate in the closed oyster. Currently, there is limited research on the length of time needed for Vibrio spp. levels in desiccated oysters to return to background levels, defined as the levels found in oysters that remain continually submersed and not exposed to ambient air...
July 11, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28693913/from-sea-to-bloodstream-vibrio-vulnificus-sepsis
#7
Amy Joy Sheer, Kristopher P Kline, Margaret C Lo
No abstract text is available yet for this article.
July 7, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28683525/rapid-identification-of-vibrio-species-isolated-from-the-southern-coastal-regions-of-korea-by-maldi-tof-mass-spectrometry-and-comparison-of-maldi-sample-preparation-methods
#8
Youngjae Cho, Eiseul Kim, Sun-Kyung Han, Seung-Min Yang, Mi-Ju Kim, Hyun-Joong Kim, Chang-Gyeom Kim, Dong-Won Choo, Young-Rok Kim, Hae-Yeong Kim
Vibrio species are generally recognized as pathogens predominant in seafood along coastal areas. The food industry has sought to develop efficient microbial detection methods. Due to the limits of conventional methods, this study aimed to establish a rapid identification method for Vibrio isolated from Korea, based on matrix-assisted laser-desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Four different preparation procedures were compared to determine the appropriate means to pre-treat Vibrio species, using 17 isolates and five reference strains...
July 7, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28671392/recreational-waterborne-illnesses-recognition-treatment-and-prevention
#9
REVIEW
Allen Perkins, Marirose Trimmier
Illness after recreational water activities can be caused by a variety of agents, including bacteria, viruses, parasites, algae, and even chlorine gas. These illnesses are more common in summer. Waterborne illnesses are underreported because most recreational activity occurs in unsupervised venues or on private property, and participants tend to disperse before illness occurs. Symptoms of waterborne illness are primarily gastrointestinal, but upper respiratory and skin manifestations also occur. Gastrointestinal symptoms are usually self-limited, and supportive treatment may be all that is necessary...
May 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28659373/vibrio-vulnificus-tonsillitis-after-swimming-in-the-gulf-of-mexico
#10
Ali A Alsaad, David Sotello, Brian T Kruse, Jennifer B Cowart
No abstract text is available yet for this article.
June 28, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28652300/the-proline-variant-of-the-w-f-l-m-t-s-r-c-di-gmp-binding-motif-suppresses-dependence-on-signal-association-for-regulator-function
#11
Daniel M Chodur, Linda Guo, Meng Pu, Eric Bruger, Nico Fernandez, Chris Waters, Dean A Rowe-Magnus
Vibrio vulnificus is an estuarine bacteria and potent opportunistic human pathogen. It enters the food-chain by asymptomatically colonizing a variety of marine organisms, most notably oysters. Expression of the brp-encoded extracellular polysaccharide, which enhances cell-surface adherence, is regulated by c-di-GMP and the activator BrpT. The V. cholerae and V. parahaemolyticus homologs, VpsT and CpsQ, directly bind c-di-GMP via a novel W[F/L/M][T/S]R motif and c-di-GMP binding is absolutely required for activity...
June 26, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28646477/a-double-quadratic-model-for-predicting-vibrio-species-in-water-environments-of-japan
#12
Hidemasa Izumiya, Masato Furukawa, Kikuyo Ogata, Junko Isobe, Setsu Watanabe, Mari Sasaki, Kazuya Ichinose, Eiji Arakawa, Masatomo Morita, Ichiro Kurane, Makoto Ohnishi
Vibrio spp. are natural inhabitants of marine and estuarine environments. Vibrio cholerae, Vibrio parahaemolyticus, and Vibrio vulnificus are the major infectious agents for humans. Their densities are affected by environmental factors such as water temperature and salinity. The detailed contribution of each factor still remains to be elucidated. Here we conducted multi-coastal study in a 21-month period to examine relationships between environmental factors and V. cholerae, V. parahaemolyticus and V. vulnificus densities in sea surface water in eight coastal sites of four prefectures in Japan...
June 23, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28629317/surface-hypothermia-predicts-murine-mortality-in-the-intragastric-vibrio-vulnificus-infection-model
#13
Hannah E Gavin, Karla J F Satchell
BACKGROUND: The Gram-negative bacterium Vibrio vulnificus can cause severe disease in humans who consume undercooked, contaminated seafood. To study food-borne V. vulnificus disease in the laboratory, mouse virulence studies predominantly use death as the primary experimental endpoint because behaviorally based moribund status does not consistently predict lethality. This study assessed ventral surface temperature (VST) and its association with mouse survival during V. vulnificus virulence studies as an efficacious, humane alternative...
June 19, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28625696/comparative-visualization-of-the-rna-suboptimal-conformational-ensemble-in%C3%A2-vivo
#14
Chanin T Woods, Lela Lackey, Benfeard Williams, Nikolay V Dokholyan, David Gotz, Alain Laederach
When a ribonucleic acid (RNA) molecule folds, it often does not adopt a single, well-defined conformation. The folding energy landscape of an RNA is highly dependent on its nucleotide sequence and molecular environment. Cellular molecules sometimes alter the energy landscape, thereby changing the ensemble of likely low-energy conformations. The effects of these energy landscape changes on the conformational ensemble are particularly challenging to visualize for large RNAs. We have created a robust approach for visualizing the conformational ensemble of RNAs that is well suited for in vitro versus in vivo comparisons...
July 25, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28620366/vibrio-vulnificus-an-environmental-and-clinical-burden
#15
REVIEW
Sing-Peng Heng, Vengadesh Letchumanan, Chuan-Yan Deng, Nurul-Syakima Ab Mutalib, Tahir M Khan, Lay-Hong Chuah, Kok-Gan Chan, Bey-Hing Goh, Priyia Pusparajah, Learn-Han Lee
Vibrio vulnificus is a Gram negative, rod shaped bacterium that belongs to the family Vibrionaceae. It is a deadly, opportunistic human pathogen which is responsible for the majority of seafood-associated deaths worldwide. V. vulnificus infection can be fatal as it may cause severe wound infections potentially requiring amputation or lead to sepsis in susceptible individuals. Treatment is increasingly challenging as V. vulnificus has begun to develop resistance against certain antibiotics due to their indiscriminate use...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28551603/vibrio-vulnificus-septic-shock-due-to-a-contaminated-tattoo
#16
Nicholas Hendren, Senthil Sukumar, Craig S Glazer
We present a case of Vibrio vulnificus septic shock and cellulitis in a patient with chronic liver disease that occurred after obtaining a leg tattoo with subsequent seawater exposure in the Gulf of Mexico. Initial suspicion for V. vulnificus was high and he was started on empiric doxycycline and ceftriaxone at admission. Blood and wound cultures grew oxidase positive and comma-shaped Gram-negative rods ultimately confirmed to be V. vulnificus. Despite aggressive initial treatment, the patient developed septic shock and died...
May 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28546115/both-polarity-and-aromatic-ring-in-the-side-chain-of-tryptophan-246-are-involved-in-binding-activity-of-vibrio-vulnificus-hemolysin-to-target-cells
#17
Takashige Kashimoto, Tomoe Akita, Takehiro Kado, Kohei Yamazaki, Shunji Ueno
Vibrio vulnificus secretes a hemolysin/cytolysin (VVH) that induces cytolysis against a variety of mammalian cells by forming pores on the cellular membrane. VVH is known to bind to the cellular membrane as a monomer, and then convert to a pore-forming oligomer. However, the structural basis for binding of this toxin to target cells remains unknown. We show here that the polarity and indole ring on the side chain of Trp 246 (W246) of VVH, which sits on a bottom loop, participates in binding to cellular membrane...
May 22, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28545444/site-specific-his-asp-phosphoproteomic-analysis-of-prokaryotes-reveals-putative-targets-for-drug-resistance
#18
Shu-Jung Lai, I-Fan Tu, Wan-Ling Wu, Jhih-Tian Yang, Louis Y P Luk, Mei-Chin Lai, Yu-Hsuan Tsai, Shih-Hsiung Wu
BACKGROUND: Phosphorylation of amino acid residues on proteins is an important and common post-translational modification in both eukaryotes and prokaryotes. Most research work has been focused on phosphorylation of serine, threonine or tyrosine residues, whereas phosphorylation of other amino acids are significantly less clear due to the controversy on their stability under standard bioanalytical conditions. RESULTS: Here we applied a shotgun strategy to analyze the histidine and aspartate phosphorylations in different microbes...
May 25, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28531284/different-abundance-and-correlational-patterns-exist-between-total-and-presumed-pathogenic-vibrio-vulnificus-and-v-parahaemolyticus-in-shellfish-and-waters-along-the-north-carolina-coast
#19
Tiffany C Williams, Brett A Froelich, Britney Phippen, Patricia Fowler, Rachel T Noble, James D Oliver
Monitoring of Vibrio vulnificus and V. parahaemolyticus abundance is pertinent due to the ability of these species to cause disease in humans through aquatic vectors. Previously, we performed a multiyear investigation tracking Vibrio spp. levels in five sites along the southeastern North Carolina coast. From February 2013 to October 2015, total V. vulnificus and V. parahaemolyticus abundance was measured in water, oysters and clams. In the current study, pathogenic subpopulations were identified in these isolates using molecular markers, revealing that 5...
June 1, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28501446/the-involvement-of-cathepsin-f-gene-ctsf-in-turbot-scophthalmus-maximus-l-mucosal-immunity
#20
Chengbin Gao, Qiang Fu, Baofeng Su, Huanhuan Song, Shun Zhou, Fenghua Tan, Chao Li
Cathepsin F (CTSF) is a recently described papain-like cysteine protease and unique among cathepsins due to an elongated N-terminal pro-region, which contains a cystatin domain. CTSF likely plays a regulatory role in processing the invariant chain which is associated with the major histocompatibility complex (MHC) class II. In this regard, we identified the CTSF gene of turbot as well as its protein structure, phylogenetic relationships, and expression patterns in mucosal tissues following Vibrio anguillarum and Streptococcus iniae challenge...
May 10, 2017: Fish & Shellfish Immunology
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