Ana Fernández-Bravo, Paul B Kilgore, Jourdan A Andersson, Elizabeth Blears, Maria José Figueras, Nur A Hasan, Rita R Colwell, Jian Sha, Ashok K Chopra
An earlier report described a human case of necrotizing fasciitis (NF) caused by mixed infection with 4 Aeromonas hydrophila strains (NF1-NF4). While the NF2, NF3, and NF4 strains were clonal and possessed exotoxin A (ExoA), the NF1 strain was determined to be phylogenetically distinct, harboring a unique type 6 secretion system (T6SS) effector (TseC). During NF1 and NF2 mixed infection, only NF1 disseminated, while NF2 was rapidly killed by a contact-dependent mechanism and macrophage phagocytosis, as was demonstrated by using in vitro models...
November 26, 2019: Proceedings of the National Academy of Sciences of the United States of America