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https://www.readbyqxmd.com/read/27905482/pharmacologic-modulation-of-ror%C3%AE-t-translates-to-efficacy-in-preclinical-and-translational-models-of-psoriasis-and-inflammatory-arthritis
#1
Xiaohua Xue, Pejman Soroosh, Aimee De Leon-Tabaldo, Rosa Luna-Roman, Marciano Sablad, Natasha Rozenkrants, Jingxue Yu, Glenda Castro, Homayon Banie, Wai-Ping Fung-Leung, Luis Santamaria-Babi, Thomas Schlueter, Michael Albers, Kristi Leonard, Alison L Budelsky, Anne M Fourie
The IL-23/IL-17 pathway is implicated in autoimmune diseases, particularly psoriasis, where biologics targeting IL-23 and IL-17 have shown significant clinical efficacy. Retinoid-related orphan nuclear receptor gamma t (RORγt) is required for Th17 differentiation and IL-17 production in adaptive and innate immune cells. We identified JNJ-54271074, a potent and highly-selective RORγt inverse agonist, which dose-dependently inhibited RORγt-driven transcription, decreased co-activator binding and promoted interaction with co-repressor protein...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27869120/the-influence-of-large-cations-on-the-electrochemical-properties-of-tunnel-structured-metal-oxides
#2
Yifei Yuan, Chun Zhan, Kun He, Hungru Chen, Wentao Yao, Soroosh Sharifi-Asl, Boao Song, Zhenzhen Yang, Anmin Nie, Xiangyi Luo, Hao Wang, Stephen M Wood, Khalil Amine, M Saiful Islam, Jun Lu, Reza Shahbazian-Yassar
Metal oxides with a tunnelled structure are attractive as charge storage materials for rechargeable batteries and supercapacitors, since the tunnels enable fast reversible insertion/extraction of charge carriers (for example, lithium ions). Common synthesis methods can introduce large cations such as potassium, barium and ammonium ions into the tunnels, but how these cations affect charge storage performance is not fully understood. Here, we report the role of tunnel cations in governing the electrochemical properties of electrode materials by focusing on potassium ions in α-MnO2...
November 21, 2016: Nature Communications
https://www.readbyqxmd.com/read/27774831/risk-factors-of-severe-peritoneal-sclerosis-in-chronic-peritoneal-dialysis-patients
#3
Sudabeh Alatab, Iraj Najafi, Gholamreza Pourmand, Mostafa Hosseini, Soroosh Shekarchian
Peritoneal dialysis (PD) offers the healthiest way for starting renal replacement therapy (RRT) in End Stage Renal Disease patients, however exposes long-term PD patients to a dangerous complication named encapsulating peritoneal sclerosis (EPS). In this study, we searched for possible risk factors of EPS. Data were collected from two PD centers covering period 1995-2012 and comprised 464 patients. Control group defined as PD patients stayed on PD >42 month (n = 122), and case group was 12 confirmed EPS patients...
October 24, 2016: Renal Failure
https://www.readbyqxmd.com/read/27717665/type-2-innate-lymphoid-cell-suppression-by-regulatory-t%C3%A2-cells-attenuates-airway-hyperreactivity-and-requires-inducible-t-cell-costimulator-inducible-t-cell-costimulator-ligand
#4
Diamanda Rigas, Gavin Lewis, Jennifer L Aron, Bowen Wang, Homayon Banie, Ishwarya Sankaranarayanan, Lauriane Galle-Treger, Hadi Maazi, Richard Lo, Gordon J Freeman, Arlene H Sharpe, Pejman Soroosh, Omid Akbari
BACKGROUND: Atopic diseases, including asthma, exacerbate type 2 immune responses and involve a number of immune cell types, including regulatory T (Treg) cells and the emerging type 2 innate lymphoid cells (ILC2s). Although ILC2s are potent producers of type 2 cytokines, the regulation of ILC2 activation and function is not well understood. OBJECTIVE: In the present study, for the first time, we evaluate how Treg cells interact with pulmonary ILC2s and control their function...
October 4, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27541940/glasses-hiding-or-causing-skin-cancer
#5
Ze Zhang, Soroosh Behshad, Pooja Sethi-Patel, Alejandra A Valenzuela
This article evaluates malignant transformation of lesions presenting in the periocular skin under the eye spectacle nose pad. A non-comparative retrospective chart review of clinical features and pathological findings of patients presenting with periocular malignancies in the exact vicinity where the nose pads of their eye spectacles rested was completed. The study took place in one tertiary oculoplastic referral center between 2007-2013. Ten patients were included, six of whom were male. All subjects wore eye spectacles while awake for at least 15 years, and had an evident suspicious lesion in the exact area that coincided with the resting place of the nose pad...
October 2016: Orbit
https://www.readbyqxmd.com/read/27419386/relative-skeletal-maturation-and-population-ancestry-in-nonobese-children-and-adolescents
#6
Shana E McCormack, Alessandra Chesi, Jonathan A Mitchell, Sani M Roy, Diana L Cousminer, Heidi J Kalkwarf, Joan M Lappe, Vicente Gilsanz, Sharon E Oberfield, John A Shepherd, Soroosh Mahboubi, Karen K Winer, Andrea Kelly, Struan Fa Grant, Babette S Zemel
More rapid skeletal maturation in African-American (AA) children is recognized and generally attributed to an increased prevalence of obesity. The objective of the present study was to evaluate the effects of population ancestry on relative skeletal maturation in healthy, non-obese children and adolescents, accounting for body composition and sexual maturation. To do this, we leveraged a multiethnic, mixed-longitudinal study with annual assessments for up to 7 years (The Bone Mineral Density in Childhood Study and its ancillary cohort) conducted at five US clinical centers...
July 15, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27257723/toric-intraocular-lens-alignment-manual-versus-automated-alignment-techniques-for-toric-iols
#7
Soroosh Behshad, James Tucker, Sumit Sam Garg
No abstract text is available yet for this article.
2016: International Ophthalmology Clinics
https://www.readbyqxmd.com/read/27233909/2015-rad-aid-conference-on-international-radiology-for-developing-countries-the-evolving-global-radiology-landscape
#8
Andrew Kesselman, Garshasb Soroosh, Daniel J Mollura
Radiology in low- and middle-income (developing) countries continues to make progress. Research and international outreach projects presented at the 2015 annual RAD-AID conference emphasize important global themes, including (1) recent slowing of emerging market growth that threatens to constrain the advance of radiology, (2) increasing global noncommunicable diseases (such as cancer and cardiovascular disease) needing radiology for detection and management, (3) strategic prioritization for pediatric radiology in global public health initiatives, (4) continuous expansion of global health curricula at radiology residencies and the RAD-AID Chapter Network's participating institutions, and (5) technologic innovation for recently accelerated implementation of PACS in low-resource countries...
September 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27224637/failed-intussusception-reduction-in-children-correlation-between-radiologic-surgical-and-pathologic-findings
#9
Aikaterini Ntoulia, Sasha J Tharakan, Janet R Reid, Soroosh Mahboubi
OBJECTIVE: The objective of this study was to identify causes of irreducible intussusception after contrast enema and to correlate imaging findings with surgical and histopathologic findings. MATERIALS AND METHODS: Between 2005 and 2013, a total of 543 children underwent reduction of intussusception with the use of an enema technique (hereafter referred to as "enema reduction"). The medical records of 72 children (56 boys [mean age, 24.8 months; range, 3.8 months to 10...
August 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27100656/endothelial-keratoplasty-safety-basket-suture-for-management-of-difficult-cases
#10
Soroosh Behshad, Bradley H Jacobsen, Elizabeth Pinney, Mathew Wade, Sumit Sam Garg
PURPOSE: To describe a novel technique of a safety-basket for management of Descemet stripping automated endothelial keratoplasty in eyes with defects of the lens-iris diaphragm, postvitrectomized eyes, eyes with previous glaucoma tube-shunt or trabeculectomy, or when the patient cannot lie supine. METHODS: The safety-basket suture is placed after the endothelial graft has been positioned under air and all wounds have been closed. Double-armed 10-0 polypropylene suture on a curved needle is passed under the graft in a single-running fashion, a modification of the Masket technique used as a safety suture in the management of malpositioned intraocular lenses...
June 2016: Cornea
https://www.readbyqxmd.com/read/27054522/rhamnolipid-adsorption-in-soil-factors-unique-features-and-considerations-for-use-as-green-antizoosporic-agents
#11
Soroosh Soltani Dashtbozorg, Jacob Kohl, Lu-Kwang Ju
In aqueous solutions, rhamnolipids effectively kill the motile zoospores responsible for spreading many pathogens, including soy-infecting Phytophthora sojae. For use in soil, adsorption properties need to be considered. Having low critical micelle concentrations, rhamnolipids tend to form micelles/aggregates with unknown effects on soil adsorption. Effects of soil pH, rhamnolipid congener structure, and concentration were examined. Congeners were identified and each quantitated for adsorptive partitioning...
May 4, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/26980929/investigation-of-cardiac-complications-and-their-incidence-in-patients-with-ankylosing-spondylitis
#12
Mohsen Soroush, Mahmood Mominzadeh, Younes Ghelich, Soosan Soroosh, Morteza Aghajanpoor Pasha
INTRODUCTION: Ankylosing Spondylitis (AS) is a chronic inflammatory disease with unknown etiology which involves the sacroiliac and axial joints, but can also cause peripheral conflicts. It also comprises non-joint symptoms such as acute anterior uveitis, cardiac conduction defects, upper lobe pulmonary fibrosis, neurological involvement and renal amyloidosis. MATERIAL AND METHODS: This study was a cross-sectional descriptive and analytical survey. In this study, 50 patients with AS were examined according to the New York Criteria in Army 501 Hospital in Tehran...
February 2016: Medical Archives
https://www.readbyqxmd.com/read/26958049/single-incision-laparoscopic-cholecystectomy-versus-mini-laparoscopic-cholecystectomy-a-randomized-clinical-trial-study
#13
Najmeh Dabbagh, Ahmadreza Soroosh, Zhamak Khorgami, Abolfazl Shojaeifard, Mehdi Jafari, Ali Ghorbani Abdehgah, Hossein Mahmudzade
BACKGROUND: Surgical technique using small-diameter instruments and single-incision laparoscopy are two new options for less invasive laparoscopic cholecystectomy (LC). In this study, we have compared mini-LC (MLC) with single-incision LC (SILC). MATERIALS AND METHODS: This study is a randomized clinical trial conducted on the patients diagnosed with symptomatic cholelithiasis who underwent LC. Forty patients were randomized to two equal groups of MLC and SILC. They were compared in terms of demographic data, operation time, and surgical complications...
December 2015: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/26821779/effect-of-low-magnitude-mechanical-stimuli-on-bone-density-and-structure-in-pediatric-crohn-s-disease-a-randomized-placebo-controlled-trial
#14
Mary B Leonard, Justine Shults, Jin Long, Robert N Baldassano, J Keenan Brown, Kevin Hommel, Babette S Zemel, Soroosh Mahboubi, Krista Howard Whitehead, Rita Herskovitz, Dale Lee, Joseph Rausch, Clinton T Rubin
Pediatric Crohn's Disease (CD) is associated with low trabecular bone mineral density (BMD), cortical area, and muscle mass. Low-magnitude mechanical stimulation (LMMS) may be anabolic. We conducted a 12-month randomized double-blind placebo-controlled trial of 10 minutes daily exposure to LMMS (30 Hz frequency, 0.3 g peak-to-peak acceleration). The primary outcomes were tibia trabecular BMD and cortical area by peripheral quantitative CT (pQCT) and vertebral trabecular BMD by QCT; additional outcomes included dual-energy X-ray absorptiometry (DXA) whole body, hip and spine BMD, and leg lean mass...
June 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/26583132/hyaluronan-s-role-in-fibrosis-a-pathogenic-factor-or-a-passive-player
#15
REVIEW
Sami Albeiroti, Artin Soroosh, Carol A de la Motte
Fibrosis is a debilitating condition that can lead to impairment of the affected organ's function. Excessive deposition of extracellular matrix (ECM) molecules is characteristic of most fibrotic tissues. Fibroblasts activated by cytokines or growth factors differentiate into myofibroblasts that drive fibrosis by depositing ECM molecules, such as collagen, fibronectin, and connective tissue growth factor. Transforming growth factor-β (TGF-β) is one of the major profibrotic cytokines which promotes fibrosis by signaling abnormal ECM regulation...
2015: BioMed Research International
https://www.readbyqxmd.com/read/26339258/identification-and-characterization-of-a-compound-from-cuminum-cyminum-essential-oil-with-antifibrilation-and-cytotoxic-effect
#16
D Morshedi, T Salmani Kesejini, F Aliakbari, R Karami-Osboo, M Shakibaei, A Tayaranian Marvian, M Khalifeh, M Soroosh
Amyloid pathology is associated with fibril aggregation of different proteins which results in the progressive damage of affected organs. It is strongly believed that specific small molecules interfere with fibrillation by interacting with the amyloidogenic proteins. We had previously reported the strong and long-term inhibition of fibrillation of hen egg white lysozyme (HEWL) by Cuminum cyminum oil. Herein, it was intended to rationally identify the active anti-amyloidogenic compounds of the oil. After fractionation, the highest inhibitory effect was observed in the toluene-ethyl acetate part of the oil...
November 2014: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/26274642/tailoring-of-spectral-response-and-spatial-field-distribution-with-corrugated-photonic-crystal-slab
#17
Raanan Gad, Wah Tung Lau, Costa Nicholaou, Soroosh Ahmadi, Iliya Sigal, Ofer Levi
We report a new physical mechanism for simultaneous tuning of quality factors, spectral responses, and field distributions in photonic crystal slabs through removal of polarization mode degeneracy using a lattice of elliptical nano-holes. The quality factors in these structures can become higher than those obtained with much smaller circular nano-holes. Furthermore, the modes can be superimposed by either rotating or morphing the elliptical nano-holes into a corrugated grating. These findings will enable improved radiation-matter interaction in optical, microwave, and THZ frequencies along with enhanced opto-acoustic coupling...
August 15, 2015: Optics Letters
https://www.readbyqxmd.com/read/26215593/delivering-thrombectomy-for-acute-stroke-using-cardiology-services
#18
EDITORIAL
Andrew Apps, Soroosh Firoozan, Tito Kabir
No abstract text is available yet for this article.
July 27, 2015: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/26209626/the-tnf-family-molecules-light-and-lymphotoxin-%C3%AE-%C3%AE-induce-a-distinct-steroid-resistant-inflammatory-phenotype-in-human-lung-epithelial-cells
#19
Ricardo da Silva Antunes, Lisa Madge, Pejman Soroosh, Joel Tocker, Michael Croft
Lung epithelial cells are considered important sources of inflammatory molecules and extracellular matrix proteins that contribute to diseases such as asthma. Understanding the factors that stimulate epithelial cells may lead to new insights into controlling lung inflammation. This study sought to investigate the responsiveness of human lung epithelial cells to the TNF family molecules LIGHT and lymphotoxin αβ (LTαβ). Bronchial and alveolar epithelial cell lines, and primary human bronchial epithelial cells, were stimulated with LIGHT and LTαβ, and expression of inflammatory cytokines and chemokines and markers of epithelial-mesenchymal transition and fibrosis/remodeling was measured...
September 1, 2015: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/26206781/progressive-wheeze-atrial-myxoma-masquerading-as-chronic-obstructive-pulmonary-disease
#20
Aish Sinha, Andrew Apps, Wei Chuen Liong, Soroosh Firoozan
Atrial myxoma, the commonest primary cardiac neoplasm, presents with symptoms of heart failure, embolic phenomena or constitutional upset. We present an atypical case, with wheeze and symptomatic exacerbations typical of chronic obstructive pulmonary disease. With no early clinical evidence of heart failure, the patient was managed with inhaled steroids and bronchodilators, with little relief. Only when the patient was in extremis requiring intubation, due to respiratory failure, did clinical evidence of left heart failure become apparent, with echocardiography demonstrating a massive left atrial myxoma obstructing the mitral valve annulus...
July 23, 2015: BMJ Case Reports
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