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https://www.readbyqxmd.com/read/29166753/interventional-locoregional-treatment-and-metabolic-response-advantages-of-using-pet-ct-in-the-evaluation-of-response-to-treatment
#1
Monica Finessi, Marilena Bellò, Francesca P Giunta, Andrea Veltri, Désirée Deandreis
INTRODUCTION: Interventional oncology locoregional therapies are validated treatment modalities for primary and secondary tumors in liver, lung, kidney and bone. At this time, there is no accordance in the choice of imaging modality to assess treatment response. Morphological imaging and RECIST 1.1 criteria based on size variation are limited by several critical points. On the other hand the role of functional imaging, in particular by [18F]-fluorodeoxyglucose ([18F]-FDG) positron emission tomography (PET), in both staging and response evaluation of locoregional treatments remains unclear because of the heterogeneous nature of available data...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29165544/rna-methylation-and-diseases-experimental-results-databases-web-servers-and-computational-models
#2
Xing Chen, Ya-Zhou Sun, Hui Liu, Lin Zhang, Jian-Qiang Li, Jia Meng
Ribonucleic acid (RNA) methylation is a type of posttranscriptional modifications occurring in all kingdoms of life. It is strongly related to important biological process, thus making it linked to a number of human diseases. Owing to the development of high-throughput sequencing technology, plenty of achievement had been obtained in RNA methylation research recently. Meanwhile, various computational models have been developed to analyze and mining increasing RNA methylation data. In this review, we first made a brief introduction about eight types of most popular RNA methylation, the biological functions of RNA methylation, the relationship between RNA methylation and disease and five important RNA methylation-related diseases...
November 18, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29164804/biomaterials-and-advanced-technologies-for-hemostatic-management-of-bleeding
#3
REVIEW
DaShawn A Hickman, Christa L Pawlowski, Ujjal D S Sekhon, Joyann Marks, Anirban Sen Gupta
Bleeding complications arising from trauma, surgery, and as congenital, disease-associated, or drug-induced blood disorders can cause significant morbidities and mortalities in civilian and military populations. Therefore, stoppage of bleeding (hemostasis) is of paramount clinical significance in prophylactic, surgical, and emergency scenarios. For externally accessible injuries, a variety of natural and synthetic biomaterials have undergone robust research, leading to hemostatic technologies including glues, bandages, tamponades, tourniquets, dressings, and procoagulant powders...
November 22, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29164610/shared-pathological-pathways-of-alzheimer-s-disease-with-specific-comorbidities-current-perspectives-and-interventions
#4
REVIEW
Christiane M Nday, Despoina Eleftheriadou, Graham Jackson
Alzheimer's disease (AD) belongs to one of the most multifactorial, complex and heterogeneous morbidity-leading disorders. Despite the extensive research in the field, AD pathogenesis is still at some extend obscure. Mechanisms linking AD with certain comorbidities, namely diabetes mellitus, obesity and dyslipidemia, are increasingly gaining importance, mainly due to their potential role in promoting AD development and exacerbation. Their exact cognitive impairment trajectories, however, remain to be fully elucidated...
November 21, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29164488/spontaneous-elimination-of-hepatitis-c-virus-infection
#5
Maciej Janiak, Kamila Caraballo Cortes, Urszula Demkow, Marek Radkowski
Hepatitis C virus (HCV) is the etiological agent of chronic hepatitis C and a major cause of liver cirrhosis and hepatocellular carcinoma. Only a minority of infected individuals can clear the virus spontaneously. The knowledge of the determinants of virus clearance would allow the development of effective methods preventing its further spread and optimizing treatment regimens. Viral factors associated with spontaneous virus clearance in the acute phase of infection, such as HCV genotype, virus heterogeneity, and the impact of viral proteins on the immune system have been characterized...
November 22, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29163515/nanobody-based-delivery-systems-for-diagnosis-and-targeted-tumor-therapy
#6
REVIEW
Yaozhong Hu, Changxiao Liu, Serge Muyldermans
The development of innovative targeted therapeutic approaches are expected to surpass the efficacy of current forms of treatments and cause less damage to healthy cells surrounding the tumor site. Since the first development of targeting agents from hybridoma's, monoclonal antibodies (mAbs) have been employed to inhibit tumor growth and proliferation directly or to deliver effector molecules to tumor cells. However, the full potential of such a delivery strategy is hampered by the size of mAbs, which will obstruct the targeted delivery system to access the tumor tissue...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163332/clinical-use-of-cerebral-microdialysis-in-patients-with-aneurysmal-subarachnoid-hemorrhage-state-of-the-art
#7
REVIEW
Raimund Helbok, Mario Kofler, Alois Josef Schiefecker, Maxime Gaasch, Verena Rass, Bettina Pfausler, Ronny Beer, Erich Schmutzhard
Objective: To review the published literature on the clinical application of cerebral microdialysis (CMD) in aneurysmal subarachnoid hemorrhage (SAH) patients and to summarize the evidence relating cerebral metabolism to pathophysiology, secondary brain injury, and outcome. Methods: Study selection: Two reviewers identified all manuscripts reporting on the clinical use of CMD in aneurysmal SAH patients from MEDLINE. All identified studies were grouped according to their focus on brain metabolic changes during the early and subacute phase after SAH, their association with mechanisms of secondary brain injury and outcome...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29162065/from-policy-to-practice-exploring-the-implementation-of-antiretroviral-therapy-access-and-retention-policies-between-2013-and-2016-in-six-sub-saharan-african-countries
#8
Julie Ambia, Jenny Renju, Alison Wringe, Jim Todd, Eveline Geubbels, Jessica Nakiyingi-Miiro, Mark Urassa, Tom Lutalo, Amelia C Crampin, Daniel Kwaro, Catherine Kyobutungi, Natsayi Chimbindi, F Xavier Gomez-Olive, Malebogo Tlhajoane, Brian Njamwea, Basia Zaba, Paul Mee
BACKGROUND: Understanding the implementation of 2013 World Health Organization (WHO) consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection at the facility level provides important lessons for the roll-out of future HIV policies. METHODS: A national policy review was conducted in six sub-Saharan African countries to map the inclusion of the 2013 WHO HIV treatment recommendations. Twenty indicators of policy adoption were selected to measure ART access (n = 12) and retention (n = 8)...
November 21, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29161916/smartphone-accelerometers-for-the-detection-of-heart-rate
#9
Federica Landreani, Enrico Gianluca Caiani
Micro-electro-mechanical systems technology, now embedded into smartphones, potentially allows measuring heart mechanical activity by positioning the phone on the body and acquiring vibrational signals, without the need for additional peripherals or interfaces. However, lack of standardization in experimental protocol, processing methodology and validation procedures, together with the wide range of available smartphones on the market, impact on the comparability of results and their general validity. The aim of this review is to provide information on the state-of-the art of research in this field, with current limitations and potentials, thus potentially serving as a basis for the creation of a standard based on current experiences...
November 22, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/29160843/public-and-healthcare-professionals-knowledge-and-attitudes-toward-binge-eating-disorder-a-narrative-review
#10
REVIEW
Deborah Lynn Reas
Binge eating disorder (BED) is characterized by recurrent binge eating and marked distress in the absence of inappropriate compensatory behaviors for weight control. BED is prevalent in men and women, is associated with elevated psychosocial and functional impairment, and is associated strongly with obesity and related medical comorbidities. The aim is to provide a brief, state-of-the-art review of the major and recent findings to inform educational and awareness campaigns, stigma reduction interventions, as well as current clinical practice and future research...
November 21, 2017: Nutrients
https://www.readbyqxmd.com/read/29158995/the-role-of-biomaterials-in-the-treatment-of-meniscal-tears
#11
Crystal O Kean, Robert J Brown, James Chapman
Extensive investigations over the recent decades have established the anatomical, biomechanical and functional importance of the meniscus in the knee joint. As a functioning part of the joint, it serves to prevent the deterioration of articular cartilage and subsequent osteoarthritis. To this end, meniscus repair and regeneration is of particular interest from the biomaterial, bioengineering and orthopaedic research community. Even though meniscal research is previously of a considerable volume, the research community with evolving material science, biology and medical advances are all pushing toward emerging novel solutions and approaches to the successful treatment of meniscal difficulties...
2017: PeerJ
https://www.readbyqxmd.com/read/29158876/challenges-in-the-setup-of-large-scale-next-generation-sequencing-analysis-workflows
#12
REVIEW
Pranav Kulkarni, Peter Frommolt
While Next-Generation Sequencing (NGS) can now be considered an established analysis technology for research applications across the life sciences, the analysis workflows still require substantial bioinformatics expertise. Typical challenges include the appropriate selection of analytical software tools, the speedup of the overall procedure using HPC parallelization and acceleration technology, the development of automation strategies, data storage solutions and finally the development of methods for full exploitation of the analysis results across multiple experimental conditions...
2017: Computational and Structural Biotechnology Journal
https://www.readbyqxmd.com/read/29158352/intracytoplasmic-sperm-injection-state-of-the-art-in-humans
#13
Gianpiero D Palermo, Claire L O'Neill, Stephen Chow, Stephanie Cheung, Alessandra Parrella, Nigel Pereira, Zev Rosenwaks
Amongst infertile couples, 25% involve both male and female factors, while male factor alone accounts for another 25% due to oligo-, astheno-, terato-zoospermia, a combination of the three, or even a complete absence of sperm cells in the ejaculate and can lead to a poor prognosis even with the help of assisted reproductive technology (ART). Intracytoplasmic sperm injection (ICSI) has been with us now for a quarter of a century and in spite of the controversy generated since its inception, it remains in the forefront of the techniques utilized in ART...
November 20, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29157490/dynamic-nuclear-polarization-for-sensitivity-enhancement-in-modern-solid-state-nmr
#14
REVIEW
Aany Sofia Lilly Thankamony, Johannes J Wittmann, Monu Kaushik, Björn Corzilius
The field of dynamic nuclear polarization has undergone tremendous developments and diversification since its inception more than 6 decades ago. In this review we provide an in-depth overview of the relevant topics involved in DNP-enhanced MAS NMR spectroscopy. This includes the theoretical description of DNP mechanisms as well as of the polarization transfer pathways that can lead to a uniform or selective spreading of polarization between nuclear spins. Furthermore, we cover historical and state-of-the art aspects of dedicated instrumentation, polarizing agents, and optimization techniques for efficient MAS DNP...
November 2017: Progress in Nuclear Magnetic Resonance Spectroscopy
https://www.readbyqxmd.com/read/29155636/hepatic-imaging-in-neonates-and-young-infants-state-of-the-art
#15
Stephanie B Shamir, Jessica Kurian, Debora Kogan-Liberman, Benjamin H Taragin
Neonatal liver disease is an important source of morbidity in the pediatric population. The manifestation of liver disease in young infants may be different than in older patients, and there are a number of diagnoses that are unique to this age group. Familiarity with these entities is important as imaging plays a key role in the diagnostic workup, and prompt diagnosis is necessary to prevent complications. This article reviews the spectrum of liver pathologies that can manifest in the first 6 months of life and is intended to educate the general radiologist who may be faced with interpretation of neonatal liver imaging...
December 2017: Radiology
https://www.readbyqxmd.com/read/29155250/surgical-management-of-acute-appendicitis-in-adults-a-review-of-current-techniques
#16
REVIEW
Maximilian Sohn, Ayman Agha, Stefan Bremer, Kai S Lehmann, Marcus Bormann, Alfred Hochrein
Acute appendicitis is one of the most frequent disorders in abdominal surgery. Therefore, appendectomy is a matter of significant interest in that field. Yet, four different techniques are available: open appendectomy, (conventional) laparoscopic appendectomy, single port laparoscopic appendectomy and NOTES-appendectomy with its different variations. To evaluate the current state of the art in appendectomy a bibliographic search was conducted. All prospectively randomized trials and national register cohort studies published between 1/2010 and 5/2016 were included into the analysis...
November 18, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29155183/insights-into-brain-microstructure-from-in-vivo-dw-mrs
#17
Marco Palombo, Noam Shemesh, Itamar Ronen, Julien Valette
Many developmental processes, such as plasticity and aging, or pathological processes such as neurological diseases are characterized by modulations of specific cellular types and their microstructures. Diffusion-weighted Magnetic Resonance Imaging (DW-MRI) is a powerful technique for probing microstructure, yet its information arises from the ubiquitous, non-specific water signal. By contrast, diffusion-weighted Magnetic Resonance Spectroscopy (DW-MRS) allows specific characterizations of tissues such as brain and muscle in vivo by quantifying the diffusion properties of MR-observable metabolites...
November 16, 2017: NeuroImage
https://www.readbyqxmd.com/read/29154233/objective-assessment-of-knee-proprioception-and-sensorimotor-function-in-patients-with-primary-gonarthrosis-before-and-after-knee-replacement
#18
Anna Hadamus, Dariusz Białoszewski
The sensorimotor system is a complicated tool allowing for maintaining body balance and responding to changing environmental conditions to prevent injury. It is difficult to objectively assess the function of balance control mechanisms due to the multidimensional nature of the sensorimotor system and multitude of variables that may interfere with the measurement. The function of the sensorimotor system is considerably compromised in osteoarthritis, including gona-rthro-sis. The knee is the second most common location of osteoarthritis, after the hip, and total or partial replacement surgery of the knee joint represents the therapy of choice in advanced stages of the condition...
October 31, 2017: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/29153182/a-100-year-review-cheese-production-and-quality
#19
M E Johnson
In the beginning, cheese making in the United States was all art, but embracing science and technology was necessary to make progress in producing a higher quality cheese. Traditional cheese making could not keep up with the demand for cheese, and the development of the factory system was necessary. Cheese quality suffered because of poor-quality milk, but 3 major innovations changed that: refrigeration, commercial starters, and the use of pasteurized milk for cheese making. Although by all accounts cold storage improved cheese quality, it was the improvement of milk quality, pasteurization of milk, and the use of reliable cultures for fermentation that had the biggest effect...
December 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29149762/interaction-of-biologically-relevant-ions-and-organic-molecules-with-titanium-oxide-rutile-surfaces-a-review-on-molecular-dynamics-studies
#20
REVIEW
Azade YazdanYar, Ulrich Aschauer, Paul Bowen
The surface of a biomaterial can play a major role in its biological fate since the surface is the primary pathway for its interaction with the body. As the natural response of the body to a foreign material is to encapsulate it with a fibrous material, the interactions between the body and the biomaterial are mediated by this fibrous layer. Initial interactions occur between the biomaterial surface, water, ionic species and organic molecules, which then mediate further interactions with body tissues. Surface engineering can influence these interactions and hence, improve the biocompatibility of the biomaterial...
November 7, 2017: Colloids and Surfaces. B, Biointerfaces
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