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https://www.readbyqxmd.com/read/29792917/storage-visualization-and-navigation-of-3d-genomics-data
#1
Jérôme Waldispühl, Eric Zhang, Alexander Butyaev, Elena Nazarova, Yan Cyr
The field of 3D genomics grew at increasing rates in the last decade. The volume and complexity of 2D and 3D data produced is progressively outpacing the capacities of the technology previously used for distributing genome sequences. The emergence of new technologies provides also novel opportunities for the development of innovative approaches. In this paper, we review the state-of-the-art computing technology, as well as the solutions adopted by the platforms currently available.
May 21, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29791959/sarcopenia-beyond-muscle-atrophy-and-into-the-new-frontiers-of-opportunistic-imaging-precision-medicine-and-machine-learning
#2
Leon Lenchik, Robert D Boutin
As populations continue to age worldwide, the impact of sarcopenia on public health will continue to grow. The clinically relevant and increasingly common diagnosis of sarcopenia is at the confluence of three tectonic shifts in medicine: opportunistic imaging, precision medicine, and machine learning. This review focuses on the state-of-the-art imaging of sarcopenia and provides context for such imaging by discussing the epidemiology, pathophysiology, consequences, and future directions in the field of sarcopenia...
July 2018: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/29791943/the-growing-reality-of-the-neurological-complications-of-global-stem-cell-tourism
#3
Katie Julian, Nick Yuhasz, Ethan Hollingsworth, Jaime Imitola
"Stem cell tourism" is defined as the unethical practice of offering unproven cellular preparations to patients suffering from various medical conditions. This phenomenon is rising in the field of neurology as patients are requesting information and opportunities for treatment with stem cells for incurable conditions such as multiple sclerosis and amyotrophic lateral sclerosis, despite their clinical research and experimental designation. Here, we review the recent trends in "stem cell tourism" in both the United States and abroad, and discuss the recent reports of neurological complications from these activities...
April 2018: Seminars in Neurology
https://www.readbyqxmd.com/read/29791711/percutaneous-edge-to-edge-transcatheter-mitral-valve-repair-current-indications-and-future-perspectives
#4
Martino Pepe, Emanuela De Cillis, Tommaso Acquaviva, Annagrazia Cecere, Pasquale D'Alessandro, Arturo Giordano, Marco Matteo Ciccone, Alessandro Santo Bortone
Mitral regurgitation (MR) is the most prevalent valvular heart disease (VHD) and represents an important cause of heart failure. Medical therapy has a limited role in improving symptoms and does not hinder the progression of valvular disease. Surgery is the treatment of choice for severe symptomatic MR; valve repair is currently the preferred surgical approach because it reduces peri-operative mortality and ensures a good medium- to long-term survival outcome. Nevertheless, a non-negligible proportion of patients with indications for surgical correction are considered to be at prohibitive perioperative risk, mainly because of old age and multiple comorbidities...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791424/-primary-biliary-cholangitis-part-2-state-of-the-art-diagnosis-associated-diseases-treatment-and-prognosis
#5
Diego Andrés Rodríguez Lugo, Jorge Julián Coronado Tovar, Giovana Alejandra Solano Villamarin, Wiliam Otero Regino
Primary biliary cholangitis (PBC) is a chronic autoimmune cholangiopathy characterized by a selective destruction of biliary epithelial cells of small and medium caliber hepatic ducts, which mainly affects women. The main symptoms are fatigue and pruritus, however, a large proportion of patients may be asymptomatic. The diagnosis is based on AMA titers >1:40, alkaline phosphatase >1.5 times the upper limit for more than 24 weeks and compatible liver histology. It is associated with multiple autoimmune diseases mainly extrahepatic, thyroid diseases, bone diseases, among others...
January 2018: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/29789993/the-role-of-the-epithelial-to-mesenchymal-transition-emt-in-diseases-of-the-salivary-glands
#6
REVIEW
Margherita Sisto, Sabrina Lisi, Domenico Ribatti
The link between inflammatory microenvironment and cancer emerged in the last years as a decisive factor in the induction of the pathological epithelial-mesenchymal transition (EMT). The EMT induces changes of cell states converting the epithelial cells to mesenchymal cells when this program is fully executed and EMT has emerged as a central driver of tumor malignancy. Cellular pathways activated by chronic inflammation brought about by chronic infections, by immune-mediated diseases, or by dysregulated wound healing at sites of repetitive tissue injury, constitute risk factors or initial cell transformation and for cancer progression...
May 23, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29789126/a-comprehensive-review-on-self-healing-of-asphalt-materials-mechanism-model-characterization-and-enhancement
#7
REVIEW
Daquan Sun, Guoqiang Sun, Xingyi Zhu, Alvaro Guarin, Bin Li, Ziwei Dai, Jianming Ling
Self-healing has great potential to extend the service life of asphalt pavement, and this capability has been regarded as an important strategy when designing a sustainable infrastructure. This review presents a comprehensive summary of the state-of-the-art investigations concerning the self-healing mechanism, model, characterization and enhancement, ranging from asphalt to asphalt pavement. Firstly, the self-healing phenomenon as a general concept in asphalt materials is analyzed including its definition and the differences among self-healing and some viscoelastic responses...
May 9, 2018: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/29788879/phase-behavior-of-polymorphic-fats-in-drug-delivery-systems-a-review-of-the-state-of-art
#8
J R Campos, A R Fernandes, P Severino, M L Garcia, S B Souto, E B Souto
Fats are essential nutrients that have a significant role in the human diet and are essential to provide energy. Fatty acids are present in several types of lipids, such as triglycerides and phospholipids. Fatty acids differ among them, depending on the number of double bonds and on the length of the hydrocarbon chains. If there are no double bonds, the fatty acids are considered saturated and show a linear structure. Compounds with double bonds are unsaturated and have bent structure. The saturated fatty acids are usually solid at room temperature and the unsaturated fatty acids are liquid at that very same temperature...
May 21, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29786511/-preeclampsia-a-challenge-also-for-cardiologists
#9
M Cournot, O Lairez, B Medzech
Due to its short-term consequences on perinatal outcome, preeclampsia has been long regarded as an obstetrical disease, strictly confined to a management by OB/GYNs. It has been now widely accepted that preeclampsia is most a systemic inflammatory and systemic vascular disease during pregnancy and then a lifelong risk factor for subsequent cardiovascular event in women's life. The aim of this review is to propose an overview in the current state-of-art in definition, early identification and management of preeclampsia...
May 18, 2018: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29786501/strategies-to-increase-filipino-american-participation-in-cardiovascular-health-promotion-a-systematic-review
#10
Jermy-Leigh B Domingo, Gretchenjan Gavero, Kathryn L Braun
INTRODUCTION: Cultural tailoring of interventions can be effective in reducing health disparities by attracting underserved populations to health promotion programs and improving their outcomes. The purpose of this systematic review was to assess what is known about increasing access to and participation in cardiovascular disease (CVD) prevention and control programs among Filipino Americans. METHODS: PubMed MEDLINE, CINAHL, and Sociologic Abstracts were searched for peer-reviewed studies and dissertations conducted in the United States from 2004 through 2016...
May 17, 2018: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29784681/use-of-intracardiac-echocardiography-in-interventional-cardiology-working-with-the-anatomy-rather-than-fighting-it
#11
REVIEW
Andres Enriquez, Luis C Saenz, Raphael Rosso, Frank E Silvestry, David Callans, Francis E Marchlinski, Fermin Garcia
The indications for catheter-based structural and electrophysiological procedures have recently expanded to more complex scenarios, in which an accurate definition of the variable individual cardiac anatomy is key to obtain optimal results. Intracardiac echocardiography (ICE) is a unique imaging modality able to provide high-resolution real-time visualization of cardiac structures, continuous monitoring of catheter location within the heart, and early recognition of procedural complications, such as pericardial effusion or thrombus formation...
May 22, 2018: Circulation
https://www.readbyqxmd.com/read/29783786/graphene-based-nanomaterials-for-tissue-engineering-in-the-dental-field
#12
REVIEW
Riccardo Guazzo, Chiara Gardin, Gloria Bellin, Luca Sbricoli, Letizia Ferroni, Francesco Saverio Ludovichetti, Adriano Piattelli, Iulian Antoniac, Eriberto Bressan, Barbara Zavan
The world of dentistry is approaching graphene-based nanomaterials as substitutes for tissue engineering. Apart from its exceptional mechanical strength, electrical conductivity and thermal stability, graphene and its derivatives can be functionalized with several bioactive molecules. They can also be incorporated into different scaffolds used in regenerative dentistry, generating nanocomposites with improved characteristics. This review presents the state of the art of graphene-based nanomaterial applications in the dental field...
May 20, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29783647/type-and-location-of-wearable-sensors-for-monitoring-falls-during-static-and-dynamic-tasks-in-healthy-elderly-a-review
#13
REVIEW
Rosaria Rucco, Antonietta Sorriso, Marianna Liparoti, Giampaolo Ferraioli, Pierpaolo Sorrentino, Michele Ambrosanio, Fabio Baselice
In recent years, the meaning of successful living has moved from extending lifetime to improving the quality of aging, mainly in terms of high cognitive and physical functioning together with avoiding diseases. In healthy elderly, falls represent an alarming accident both in terms of number of events and the consequent decrease in the quality of life. Stability control is a key approach for studying the genesis of falls, for detecting the event and trying to develop methodologies to prevent it. Wearable sensors have proved to be very useful in monitoring and analyzing the stability of subjects...
May 18, 2018: Sensors
https://www.readbyqxmd.com/read/29780899/perspectives-on-the-evolving-state-of-the-art-management-of-gastrointestinal-stromal-tumours
#14
REVIEW
Zoltan Szucs, Robin L Jones
Gastrointestinal stromal tumours (GISTs) represent a very exciting tumour entity for the medical oncologist. There has been extensive clinical and preclinical research dissecting the natural behaviour, molecular landscape and therapeutic responsiveness of this rare mesenchymal tumour. Various molecular subtypes of GIST have a differing prognostic and predictive relevance in the state of the art management of the disease. Emerging mature clinical trial data gathered over the last one and half decade provided substantial molecular profiling information in understanding the success and eventual failure of treatment...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29780878/microfluidics-in-malignant-glioma-research-and-precision-medicine
#15
Meghan Logun, Wujun Zhao, Leidong Mao, Lohitash Karumbaiah
Glioblastoma multiforme (GBM) is an aggressive form of brain cancer that has no effective treatments and a prognosis of only 12-15 months. Microfluidic technologies deliver microscale control of fluids and cells, and have aided cancer therapy as point-of-care devices for the diagnosis of breast and prostate cancers. However, a few microfluidic devices are developed to study malignant glioma. The ability of these platforms to accurately replicate the complex microenvironmental and extracellular conditions prevailing in the brain and facilitate the measurement of biological phenomena with high resolution and in a high-throughput manner could prove useful for studying glioma progression...
May 2018: Advanced Biosystems
https://www.readbyqxmd.com/read/29780633/deep-learning-aided-decision-support-for-pulmonary-nodules-diagnosing-a-review
#16
REVIEW
Yixin Yang, Xiaoyi Feng, Wenhao Chi, Zhengyang Li, Wenzhe Duan, Haiping Liu, Wenhua Liang, Wei Wang, Ping Chen, Jianxing He, Bo Liu
Deep learning techniques have recently emerged as promising decision supporting approaches to automatically analyze medical images for different clinical diagnosing purposes. Diagnosing of pulmonary nodules by using computer-assisted diagnosing has received considerable theoretical, computational, and empirical research work, and considerable methods have been developed for detection and classification of pulmonary nodules on different formats of images including chest radiographs, computed tomography (CT), and positron emission tomography in the past five decades...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29780432/-in-silico-toxicology-comprehensive-benchmarking-of-multi-label-classification-methods-applied-to-chemical-toxicity-data
#17
REVIEW
Arwa B Raies, Vladimir B Bajic
One goal of toxicity testing, among others, is identifying harmful effects of chemicals. Given the high demand for toxicity tests, it is necessary to conduct these tests for multiple toxicity endpoints for the same compound. Current computational toxicology methods aim at developing models mainly to predict a single toxicity endpoint. When chemicals cause several toxicity effects, one model is generated to predict toxicity for each endpoint, which can be labor and computationally intensive when the number of toxicity endpoints is large...
May 2018: Wiley Interdisciplinary Reviews. Computational Molecular Science
https://www.readbyqxmd.com/read/29779496/invited-review-improving-feed-efficiency-of-beef-cattle-the-current-state-of-the-art-and-future-challenges
#18
D A Kenny, C Fitzsimons, S M Waters, M McGee
Improvements in feed efficiency of beef cattle have the potential to increase producer profitability and simultaneously lower the environmental footprint of beef production. Although there are many different approaches to measuring feed efficiency, residual feed intake (RFI) has increasingly become the measure of choice. Defined as the difference between an animal's actual and predicted feed intake (based on weight and growth), RFI is conceptually independent of growth and body size. In addition, other measurable traits related to energy expenditure such as estimates of body composition can be included in the calculation of RFI to also force independence from these traits...
May 21, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29777528/state-of-the-art-review-on-physiologically-based-pharmacokinetic-modeling-in-pediatric-drug-development
#19
REVIEW
Venkata Yellepeddi, Joseph Rower, Xiaoxi Liu, Shaun Kumar, Jahidur Rashid, Catherine M T Sherwin
Physiologically based pharmacokinetic modeling and simulation is an important tool for predicting the pharmacokinetics, pharmacodynamics, and safety of drugs in pediatrics. Physiologically based pharmacokinetic modeling is applied in pediatric drug development for first-time-in-pediatric dose selection, simulation-based trial design, correlation with target organ toxicities, risk assessment by investigating possible drug-drug interactions, real-time assessment of pharmacokinetic-safety relationships, and assessment of non-systemic biodistribution targets...
May 18, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29774187/multimodality-imaging-for-the-quantitative-assessment-of-mitral-regurgitation
#20
REVIEW
Pei G Chew, Katrina Bounford, Sven Plein, Dominik Schlosshan, John P Greenwood
The natural history of mitral regurgitation (MR) results in significant morbidity and mortality. Innovations in non-invasive imaging have provided new insights into the pathophysiology and quantification of MR, in addition to early detection of left ventricular (LV) dysfunction and prognostic assessment in asymptomatic patients. Transthoracic (TTE) and transesophageal (TOE) echocardiography are the mainstay for diagnosis, assessment and serial surveillance. However, the advance from 2D to 3D imaging leads to improved assessment and characterization of mitral valve (MV) disease...
April 2018: Quantitative Imaging in Medicine and Surgery
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