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Exercise and memory

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https://www.readbyqxmd.com/read/29232315/beneficial-effects-of-exercise-pretreatment-in-a-sporadic-alzheimer-s-rat-model
#1
Chongyun Wu, Luodan Yang, Donovan Tucker, Yan Dong, Ling Zhu, Rui Duan, Timon Cheng-Yi Liu, Quanguang Zhang
PURPOSE: This study aimed to examine the effects of swimming exercise pretreatment on a streptozotocin (STZ)-induced sporadic Alzheimer's disease rat model and provide an initial understanding of related molecular mechanisms. METHODS: Male 2.5-month-old Sprague-Dawley rats were divided into the following 4 groups: a) control, b) swim + vehicle, c) STZ without swim, and d) swim + STZ. The Barnes Maze task and Novel Object Recognition test were used to measure hippocampus-dependent spatial learning and working memory, respectively...
December 11, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29229786/seed-induced-a%C3%AE-deposition-is-modulated-by-microglia-under-environmental-enrichment-in-a-mouse-model-of-alzheimer-s-disease
#2
Stephanie Ziegler-Waldkirch, Paolo D Errico, Jonas-Frederic Sauer, Daniel Erny, Shakuntala Savanthrapadian, Desirée Loreth, Natalie Katzmarski, Thomas Blank, Marlene Bartos, Marco Prinz, Melanie Meyer-Luehmann
Alzheimer's disease (AD) is characterized by severe neuronal loss as well as the accumulation of amyloid-β (Aβ), which ultimately leads to plaque formation. Although there is now a general agreement that the aggregation of Aβ can be initiated by prion-like seeding, the impact and functional consequences of induced Aβ deposits (Aβ seeding) on neurons still remain open questions. Here, we find that Aβ seeding, representing early stages of plaque formation, leads to a dramatic decrease in proliferation and neurogenesis in two APP transgenic mouse models...
December 11, 2017: EMBO Journal
https://www.readbyqxmd.com/read/29224581/executive-function-and-other-cognitive-deficits-are-distal-risk-factors-of-generalized-anxiety-disorder-9-years-later
#3
Nur Hani Zainal, Michelle G Newman
OBJECTIVE: The cognitive model (Hirsch & Mathews, 2012) and attentional control theory (Eysenck & Derakshan, 2011) postulate that compromised executive function (EF) and other cognitive constructs are negatively linked to increased excessive and uncontrollable worry, the core symptom of generalized anxiety disorder (GAD). However, the prospective link between neuropsychological constructs and GAD are not well understood. METHODS: A nationally representative sample of 2605 community-dwelling adults whose average age was 55...
December 11, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29212528/effectiveness-of-robot-assisted-training-added-to-conventional-rehabilitation-in-patients-with-humeral-fracture-early-after-surgical-treatment-protocol-of-a-randomised-controlled-multicentre-trial
#4
Corinna Nerz, Lars Schwickert, Clemens Becker, Stefan Studier-Fischer, Janina Anna Müßig, Peter Augat
BACKGROUND: The incidence of proximal humeral fractures increases with age. The functional recovery of the upper arm after such fractures is slow, and results are often disappointing. Treatment is associated with long immobilisation periods. Evidence-based exercise guidelines are missing. Loss of muscle mass as well as reduced range of motion and motor performance are common consequences. These losses could be partly counteracted by training interventions using robot-assisted arm support of the affected arm derived from neurorehabilitation...
December 6, 2017: Trials
https://www.readbyqxmd.com/read/29210764/deriving-information-requirements-for-a-smart-nursing-system-for-intensive-care-units
#5
Kunal Khanade, Farzan Sasangohar, Steven C Sutherland, Karen E Alexander
The workplace environment for intensive care nursing is highly stressful, with long working hours and a dynamic workload that may induce fatigue. The resulting stress and fatigue may reduce nurses' efficiency and may contribute to medical errors. A smart wearable system is being designed to help nurses who experience high levels of stress and fatigue at work. This article documents the systematic process of deriving information requirements from 2 focus groups conducted separately with nurses and nurse managers working in various Southeastern Texas hospitals...
January 2018: Critical Care Nursing Quarterly
https://www.readbyqxmd.com/read/29209183/cognitive-flexibility-training-a-large-scale-multimodal-adaptive-active-control-intervention-study-in-healthy-older-adults
#6
Jessika I V Buitenweg, Renate M van de Ven, Sam Prinssen, Jaap M J Murre, K Richard Ridderinkhof
As aging is associated with cognitive decline, particularly in the executive functions, it is essential to effectively improve cognition in older adults. Online cognitive training is currently a popular, though controversial method. Although some changes seem possible in older adults through training, far transfer, and longitudinal maintenance are rarely seen. Based on previous literature we created a unique, state-of-the-art intervention study by incorporating frequent sessions and flexible, novel, adaptive training tasks, along with an active control group...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29204954/chronic-fluoxetine-induces-activity-changes-in-recovery-from-poststroke-anxiety-depression-and-cognitive-impairment
#7
Faranak Vahid-Ansari, Paul R Albert
Poststroke depression (PSD) is a common outcome of stroke that limits recovery and is only partially responsive to chronic antidepressant treatment. In order to elucidate changes in the cortical-limbic circuitry associated with PSD and its treatment, we examined a novel mouse model of persistent PSD. Focal endothelin-1-induced ischemia of the left medial prefrontal cortex (mPFC) in male C57BL6 mice resulted in a chronic anxiety and depression phenotype. Here, we show severe cognitive impairment in spatial learning and memory in the stroke mice...
December 4, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29203796/aerobic-exercise-and-a-bdnf-mimetic-therapy-rescue-learning-and-memory-in-a-mouse-model-of-down-syndrome
#8
Martina Parrini, Diego Ghezzi, Gabriele Deidda, Lucian Medrihan, Enrico Castroflorio, Micol Alberti, Pietro Baldelli, Laura Cancedda, Andrea Contestabile
Down syndrome (DS) is caused by the triplication of human chromosome 21 and represents the most frequent genetic cause of intellectual disability. The trisomic Ts65Dn mouse model of DS shows synaptic deficits and reproduces the essential cognitive disabilities of the human syndrome. Aerobic exercise improved various neurophysiological dysfunctions in Ts65Dn mice, including hippocampal synaptic deficits, by promoting synaptogenesis and neurotransmission at glutamatergic terminals. Most importantly, the same intervention also prompted the recovery of hippocampal adult neurogenesis and synaptic plasticity and restored cognitive performance in trisomic mice...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29199131/combined-therapy-involving-electroacupuncture-and-treadmill-exercise-attenuates-demyelination-in-the-corpus-callosum-by-stimulating-oligodendrogenesis-in-a-rat-model-of-neonatal-hypoxia-ischemia
#9
Malk Eun Pak, Da Hee Jung, Hong Ju Lee, Myung Jun Shin, Soo-Yeon Kim, Yong Beom Shin, Young Ju Yun, Hwa Kyoung Shin, Byung Tae Choi
We investigated whether electroacupuncture (EA) and treadmill (TM) exercise improve behaviors related to motor and memory dysfunction in a cerebral palsy-like rat model via activation of oligodendrogenesis. A neonatal hypoxia-ischemia model was created using Sprague-Dawley rats (P7), and these underwent EA stimulation and treadmill training from 3 to 5weeks after hypoxia-ischemia induction. EA treatment was delivered via electrical stimulation (2Hz, 1mA) at two acupoints, Baihui (GV20) and Zusanli (ST36). Behavioral tests showed that EA alleviated motor dysfunction caused by hypoxia-ischemia on a rotarod test, and TM exercise alleviated motor and memory dysfunction seen on cylinder and passive avoidance tests...
November 30, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29188859/cognitive-performance-does-not-limit-physical-activity-participation-in-the-lifestyle-interventions-and-independence-for-elders-pilot-study-life-p
#10
K F Reid, M P Walkup, J A Katula, K M Sink, S Anton, R Axtell, D R Kerwin, A C King, F Kramer, M E Miller, V Myers, C Rosano, S A Studenski, O L Lopez, J Verghese, R A Fielding, J Williamson
OBJECTIVES: We examined whether multiple domains of baseline cognitive performance were associated with prospective physical activity (PA) adherence in the Lifestyle Interventions and Independence for Elders Pilot study (LIFE-P). DESIGN, SETTING, PARTICIPANTS: The LIFE-P study was a single-blind, multicenter, randomized controlled trial of a PA intervention compared to a successful aging educational intervention in sedentary, mobility-limited older adults. INTERVENTION: A 12-month structured, moderate-intensity, multi-modal PA program that included walking, resistance training, and flexibility exercises...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29185193/physical-exercise-promotes-memory-capability-by-enhancing-hippocampal-mitochondrial-functions-and-inhibiting-apoptosis-in-obesity-induced-insulin-resistance-by-high-fat-diet
#11
Hye-Sang Park, Han-Sam Cho, Tae-Woon Kim
A high-fat diet induces obesity in mice, leading to insulin resistance, decreased mitochondrial function, and increased apoptosis in the hippocampus, which eventually result in memory loss. The present study investigated the effect of physical exercise on memory, hippocampal mitochondrial function, and apoptosis in mice with in insulin resistance caused by obesity due to high-fat diet. Mice were randomly divided into four groups: control (CON), control and exercise (CON + EX), high fat diet (HFD), and high fat diet and exercise (HFD + EX)...
November 29, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29183255/suckling-in-litters-with-different-sizes-and-early-and-late-swimming-exercise-differentially-modulates-anxiety-like-behavior-memory-and-electrocorticogram-potentiation-after-spreading-depression-in-rats
#12
Mariana Barros E Silva-Gondim, Thays Kallyne Marinho de Souza, Marcelo Cairrão Araújo Rodrigues, Rubem Carlos Araújo Guedes
OBJECTIVE: Analyze the hypothesis that swimming exercise, in rats suckled under distinct litter sizes, alters behavioral parameters suggestive of anxiety and recognition memory, and the electrocorticogram potentiation that occurs after the excitability-related phenomenon that is known as cortical spreading depression (CSD). METHODS: Male Wistar rats were suckled in litters with six or 12 pups (L6 and L12 groups). Animals swam at postnatal days (P) 8-23, or P60-P75 (early-exercised or late-exercised groups, respectively), or remained no-exercised...
November 28, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29177013/vitamin-d-is-associated-with-metabotropic-but-not-neurotrophic-effects-of-exercise-in-ovariectomized-rats
#13
Parvin Babaei, Samaneh Ghorbani Shirkouhi, Rastegar Hosseini, Bahram Soltani Tehrani
Purpose: Here, we studied the beneficial effects of aerobic exercise on metabolic syndrome components, cognitive performance, brain derived neurotrophic factor (BDNF) and irisin in ovariectomized rats with different serum vitamin D (Vit D) status. Methods: Eighty female wistar rats were divided into 2 groups of sham operated (sham, n = 8), and ovariectomized (OVX, n = 72). Then OVX were divided into 9 groups of receiving combination of exercise protocol with low dose of Vit D (OVX + EXE + LD), high dose of Vit D (OVX + EXE + HD), Vit D deficiency (OVX + EXE - D), and (OVX + EXE + Veh)...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29169665/mindfulness-and-craving-effects-and-mechanisms
#14
REVIEW
Katy Tapper
Mindfulness meditation has a long tradition of being used to manage cravings. This paper reviews 30 experimental studies that have examined the effects of different types of mindfulness practice on cravings for food, cigarettes and alcohol. The findings are interpreted in light of relevant theories of craving. The studies show most support for the elaborated intrusion theory of desire and conditioning models. They suggest that whilst mindfulness strategies may bring about immediate reductions in craving, such effects are likely to stem from working memory load, and will not necessarily be superior to alternative strategies that also load working memory...
November 13, 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/29167635/physical-exercise-promotes-novel-object-recognition-memory-in-spontaneously-hypertensive-rats-after-ischemic-stroke-by-promoting-neural-plasticity-in-the-entorhinal-cortex
#15
Xiaona Pan, Ting Jiang, Liying Zhang, Haiqing Zheng, Jing Luo, Xiquan Hu
Cerebral ischemia leads to memory impairment, and several studies have indicated that physical exercise (PE) has memory-improving effects after ischemia. This study was designed to further explore the specific role of PE in novel object recognition (NOR) memory after stroke and the exact cortical regions in which memory is restored by PE. Spontaneously hypertensive rats (SHR) were subjected to transient middle cerebral artery occlusion (tMCAO) or sham surgery, followed by 26 days of PE starting on day 3 post-tMCAO...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29165540/mobile-application-removes-societal-barriers-to-p4-medicine
#16
J-P Michel
The overlap between one innovative paradigm (P4 medicine: predictive, personalized, participatory and preventive) and another (a new definition of "Healthy ageing") is fertile ground for new technologies; a new mobile application (app) that could broaden our scientific knowledge of the ageing process and help us to better analyse the impact of possible interventions in slowing the ageing decline. A novel mobile application is here presented as a game including questions and tests will allow in 10 minutes the assessment of the following domains: robustness, flexibility (lower muscle strength), balance, mental and memory complaints, semantic memory and visual retention...
2017: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29165142/the-effect-of-exercise-intensity-on-brain-derived-neurotrophic-factor-and-memory-in-adolescents
#17
Yong Kyun Jeon, Chang Ho Ha
BACKGROUND: Brain derived neurotrophic factor (BDNF) seems to serve as an important regulatory mechanism in the growth and development of neurons in many areas of the brain.Insulin-like growth factor 1 (IGF-1) is related to neurogenesis and regulation of the BDNF gene and is involved in the growth and differentiation of neurons.Cortisol is released in response to stimuli such as psychological oppression, anxiety, and fear. Stress also induces changes in BDNF. The purpose of this study was thus to examine the effects of varying intensities of aerobic exercise on resting serum BDNF, IGF-1 concentrations, cortisol, and memory of adolescents...
April 4, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29154278/effects-of-physical-exercise-on-alzheimer-s-disease-biomarkers-a-systematic-review-of-intervention-studies
#18
Kristian Steen Frederiksen, Le Gjerum, Gunhild Waldemar, Steen Gregers Hasselbalch
Physical exercise may be an important adjunct to pharmacological treatment of Alzheimer's disease (AD). Animal studies indicate that exercise may be disease modifying through several mechanisms including reduction of AD pathology. We carried out a systematic review of intervention studies of physical exercise with hippocampal volume (on MRI), amyloid-β, total tau, phosphorylated tau in cerebrospinal fluid (CSF), 18F-FDG-PET or amyloid PET as outcome measures in healthy subjects, patients with subjective memory complaints, mild cognitive impairment, or AD...
November 16, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29153754/effects-of-combined-physical-and-cognitive-exercises-on-cognition-and-mobility-in-patients-with-mild-cognitive-impairment-a%C3%A2-randomized-clinical-trial
#19
Hiroyuki Shimada, Hyuma Makizako, Takehiko Doi, Hyuntae Park, Kota Tsutsumimoto, Joe Verghese, Takao Suzuki
IMPORTANCE: Although participation in physical and cognitive activities is encouraged to reduce the risk of dementia, the preventive efficacy of these activities for patients with mild cognitive impairment is unestablished. OBJECTIVE: To compare the cognitive and mobility effects of a 40-week program of combined cognitive and physical activity with those of a health education program. DESIGN: A randomized, parallel, single-blind controlled trial...
November 16, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29151448/underreporting-trends-of-occupational-illnesses-in-mexico
#20
Luis Antonio Moreno-Torres, Carmelita Elizabeth Ventura-Alfaro
OBJECTIVE: To report trends underreporting levels of occupational illnesses (OI) in Mexico from 2000 to 2015. METHODS: An ecological study was conducted. Data on OI was obtained from the Statistical Memories of the Mexican Institute of Social Security. We used univariate sensitivity analysis to estimate the average value and range. RESULTS: During the 2000-2015 period, the estimated average OI underreporting in the Mexican population was 89...
November 18, 2017: Journal of Occupational Health
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