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Exercise and memory

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https://www.readbyqxmd.com/read/28806762/a-becn1-mutation-mediates-hyperactive-autophagic-sequestration-of-amyloid-oligomers-and-improved-cognition-in-alzheimer-s-disease
#1
Altea Rocchi, Soh Yamamoto, Tabitha Ting, Yuying Fan, Katherine Sadleir, Yigang Wang, Weiran Zhang, Sui Huang, Beth Levine, Robert Vassar, Congcong He
Impairment of the autophagy pathway has been observed during the pathogenesis of Alzheimer's disease (AD), a neurodegenerative disorder characterized by abnormal deposition of extracellular and intracellular amyloid β (Aβ) peptides. Yet the role of autophagy in Aβ production and AD progression is complex. To study whether increased basal autophagy plays a beneficial role in Aβ clearance and cognitive improvement, we developed a novel genetic model to hyperactivate autophagy in vivo. We found that knock-in of a point mutation F121A in the essential autophagy gene Beclin 1/Becn1 in mice significantly reduces the interaction of BECN1 with its inhibitor BCL2, and thus leads to constitutively active autophagy even under non-autophagy-inducing conditions in multiple tissues, including brain...
August 14, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28804233/effects-of-physical-activity-and-ginkgo-biloba-on-cognitive-function-and-oxidative-stress-modulation-in-ischemic-rats
#2
Ladan Vaghef, Hassan Bafandeh Gharamaleki
Either exercise or Ginkgo biloba is reported to improve cognitive functioning. The aim of this study is to compare the protective effects of forced exercise and Ginkgo biloba on oxidative stress as well as memory impairments induced by transient cerebral ischemia. Adult male Wistar rats were treated with treadmill running or Ginkgo biloba extract for 2 weeks before cerebral ischemia. Memory was assessed using a Morris water maze (MWM) task. At the end of the behavioral testing, oxidative stress biomarkers were evaluated in the hippocampus tissue...
September 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28803119/the-effects-of-low-intensity-cycling-on-cognitive-performance-following-sleep-deprivation
#3
Alexis B Slutsky, Jed A Diekfuss, James A Janssen, Nate T Berry, Chia-Hao Shih, Louisa D Raisbeck, Laurie Wideman, Jennifer L Etnier
This study examined the effect of 24h of sleep deprivation on cognitive performance and assessed the effect of acute exercise on cognitive performance following sleep deprivation. Young, active, healthy adults (n=24, 14 males) were randomized to control (age=24.7±3.7years, BMI=27.2±7.0) or exercise (age=25.3±3.3years, BMI=25.6±5.1) groups. Cognitive testing included a 5-min psychomotor vigilance task (PVT), three memory tasks with increasing cognitive load, and performance of the PVT a second time. On morning one, cognitive testing followed a typical night's sleep...
August 9, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28802655/alternating-trifascicular-block-and-cardiac-memory
#4
Asaf Danon, Mohammed Shurrab
We describe a case of a 70year-old woman with effort dyspnea and alternating trifascicular conduction pattern, worsened with exercise to atrioventricular block (AV Block). The alternating conduction at rest resulted in marked T wave changes. We discuss the mechanism of T wave memory changes and the management of exercise-induced AV Block.
July 12, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28796655/effects-of-childhood-gymnastics-program-on-spatial-working-memory
#5
Shu-Shih Hsieh, Chih-Chien Lin, Yu-Kai Chang, Chun-Ju Huang, Tsung-Min Hung
PURPOSE: A growing body of evidence has demonstrated the positive effects of physical exercise on cognition in children, and recent studies have specifically investigated the cognitive benefits of exercises involving cognitive-motor interactions, such as gymnastics. This study examined the effect of 8 weeks of gymnastics training on behavioral and neurophysiological measures of spatial working memory in children. METHODS: Forty-four children aged 7 to 10 yrs were recruited...
August 7, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28793113/effects-of-a-health-education-program-on-cognition-mood-and-functional-capacity
#6
Juliane Cristine Dias, Isabela Azevedo Rodrigues, Francine Golghetto Casemiro, Diana Quirino Monteiro, Bruna Moretti Luchesi, Marcos Hortes Nisihara Chagas, Paula Costa Castro, Sofia Cristina Iost Pavarini, Aline Cristina Martins Gratão
Objective: Assess the effect of a Health Education (HE) program on cognition, mood and functional capacity of participants in a University of The Third Age (U3A). Method: Controlled clinical trial. The HE Program consisted of 10 sessions with group dynamics, including orientations on disease prevention and cognitive stimulation exercises, lasting four months. Intervention Group (IG) n=13; and Control Group (CG) n=15. All were assessed at the start and end of the study, using Addenbrook´s Cognitive Examination-Revised (ACE-R), Beck Depression and Anxiety Inventory (BDI/BAI) and Functional Independence Measure (FIM)...
July 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28782599/ascertainment-of-unmet-needs-and-participation-in-health-maintenance-and-screening-of-adult-hematopoietic-cell-transplantation-hct-survivors-followed-in-a-formal-survivorship-program
#7
Theresa Hahn, Pamela Paplham, Tammy Austin-Ketch, Yali Zhang, Jennifer Grimmer, Michael Burns, Sophia Balderman, Maureen Ross, Philip L McCarthy
This study aimed to ascertain unmet needs in autologous and allogeneic HCT recipients actively followed in an established long-term survivorship clinic at Roswell Park Cancer Institute from 2006-2012. The Survivor Unmet Needs Survey (SUNS) was mailed to 209 eligible patients and returned by 110 (53% participation rate). SUNS includes 89-items covering 5 domains: Emotional Health, Access and Continuity of Care, Relationships, Financial Concerns, and Information. The top five specific unmet needs for autologous HCT patients were: inability to set future goals/long-term plans; changes in appearance; bad memory/lacking focus; losing confidence in abilities; paying household or other bills...
August 4, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28777749/baseline-telomere-length-and-effects-of-a-multidomain-lifestyle-intervention-on-cognition-the-finger-randomized-controlled-trial
#8
Shireen Sindi, Tiia Ngandu, Iiris Hovatta, Ingemar Kåreholt, Riitta Antikainen, Tuomo Hänninen, Esko Levälahti, Tiina Laatikainen, Jaana Lindström, Teemu Paajanen, Markku Peltonen, Dharma Singh Khalsa, Benjamin Wolozin, Timo Strandberg, Jaakko Tuomilehto, Hilkka Soininen, Miia Kivipelto, Alina Solomon
Leukocyte telomere length (LTL) is a biomarker of aging, and it is associated with lifestyle. It is currently unknown whether LTL is associated with the response to lifestyle interventions. The goal is to assess whether baseline LTL modified the cognitive benefits of a 2-year multidomain lifestyle intervention (exploratory analyses). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) was a 2-year randomized controlled trial including 1,260 people at risk of cognitive decline, aged 60-77 years identified from the general population...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28770543/feasibility-and-safety-of-virtual-reality-based-early-neurocognitive-stimulation-in-critically-ill-patients
#9
Marc Turon, Sol Fernandez-Gonzalo, Mercè Jodar, Gemma Gomà, Jaume Montanya, David Hernando, Raquel Bailón, Candelaria de Haro, Victor Gomez-Simon, Josefina Lopez-Aguilar, Rudys Magrans, Melcior Martinez-Perez, Joan Carles Oliva, Lluís Blanch
BACKGROUND: Growing evidence suggests that critical illness often results in significant long-term neurocognitive impairments in one-third of survivors. Although these neurocognitive impairments are long-lasting and devastating for survivors, rehabilitation rarely occurs during or after critical illness. Our aim is to describe an early neurocognitive stimulation intervention based on virtual reality for patients who are critically ill and to present the results of a proof-of-concept study testing the feasibility, safety, and suitability of this intervention...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28761649/discovering-successful-strategies-for-diabetic-self-management-a-qualitative-comparative-study
#10
Susan C Weller, Roberta Baer, Anita Nash, Noe Perez
OBJECTIVE: This project explored lifestyles of patients in good and poor control to identify naturally occurring practices and strategies that result in successful diabetes management. RESEARCH DESIGN AND METHODS: Semistructured interviews with adult patients with type 2 diabetes explored diet, food preparation, physical activity, medication use and glucose monitoring. Patients (n=56) were classified into good (A1C <7.0%), fair (7.0%<A1C<8.0%) or poor (A1C >8...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28759782/intergenerational-associations-in-executive-function-between-mothers-and-children-in-the-context-of-risk
#11
Matthew H Kim, Lisa Shimomaeda, Ryan J Giuliano, Elizabeth A Skowron
Executive functioning (EF) is critical for school readiness and other important life skills. Previous investigations have often neglected the important influence of parental EF skills in shaping their own children's EF. This study attempted to replicate recent empirical work that has shown that maternal EF is positively related to child EF. An ecological theoretical framework was used to examine the maternal EF-child EF link in family environments characterized by significant risk and socioeconomic adversity...
July 28, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28757311/impacts-of-maternal-diet-and-exercise-on-offspring-behavior-and-body-weights
#12
Virginia C Moser, Katherine L McDaniel, Emily A Woolard, Pamela M Phillips, Jason N Franklin, Christopher J Gordon
Human and animal studies indicate that maternal obesity can negatively impact aspects of metabolism and neurodevelopment in the offspring. Not known, however, is whether maternal exercise can alter these adverse outcomes. In this study, Long-Evans female rats were provided a high fat (60%; HFD) or control diet (CD) 44days before mating and throughout gestation and lactation. Running wheels were available to half of each diet group during the gestational period only, resulting in four conditions: CD diet with (CDRW) or without (sedentary; CDSED) exercise, and HFD with (HFRW) or without (HFSED) exercise...
July 27, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28757245/long-term-voluntary-exercise-prevents-post-weaning-social-isolation-induced-cognitive-impairment-in-rats
#13
Nilsel Okudan, Muaz Belviranlı
This study aimed to determine the effect of exercise on locomotion, anxiety-related behavior, learning, and memory in socially isolated post-weaning rats, as well as the correlation between exercise and the concentration of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the hippocampus. Rats were randomly assigned to three groups: the control group; the social isolation group; the social isolation plus exercise (SIE) group. Social isolation conditions, with or without exercise were maintained for 90d, and then multiple behavioral tests, including the open-field test, elevated plus maze test, and Morris water maze (MWM) test were administered...
July 28, 2017: Neuroscience
https://www.readbyqxmd.com/read/28757160/mitochondrial-impairments-contribute-to-spatial-learning-and-memory-dysfunction-induced-by-chronic-tramadol-administration-in-rat-protective-effect-of-physical-exercise
#14
Hajar Mehdizadeh, Jalal Pourahmad, Ghorban Taghizadeh, Nasim Vousooghi, Ali Yoonessi, Parvaneh Naserzadeh, Ladan Behzadfar, Mohammad Reza Rouini, Mohammad Sharifzadeh
Despite the worldwide use of tramadol, few studies have been conducted about its effects on memory and mitochondrial function, and controversial results have been reported. Recently, there has been an increasing interest in physical exercise as a protective approach to neuronal and cognitive impairments. Therefore, the aim of this study was to investigate the effects of physical exercise on spatial learning and memory and brain mitochondrial function in tramadol-treated rats. After completion of 2-week (short-term) and 4-week (long-term) treadmill exercise regimens, male Wistar rats received tramadol (20, 40, 80mg/kg/day) intraperitoneally for 30days...
July 27, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28756215/treadmill-running-prevents-age-related-memory-deficit-and-alters-neurotrophic-factors-and-oxidative-damage-in-the-hippocampus-of-wistar-rats
#15
Cláudia Vanzella, Juliana Dalibor Neves, Adriana Fernanda Vizuete, Dirceu Aristimunha, Janaína Kolling, Aline Longoni, Carlos Alberto Saraiva Gonçalves, Angela T S Wyse, Carlos Alexandre Netto
Clinical and pre-clinical studies indicate that exercise is beneficial to many aspects of brain function especially during aging. The present study investigated the effects of a treadmill running protocol in young (3month-old) and aged (22month-old) male Wistar rats, on: I) cognitive function, as assessed by spatial reference memory in the Morris water maze; II) oxidative stress parameters and the expression of neurotrophic factors BDNF, NT-3, IGF-1 and VEGF in the hippocampus. Animals of both ages were assigned to sedentary (non-exercised) and exercised (20min of daily running sessions, 3 times per week for 4weeks) groups...
July 26, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28747896/time-dependent-effects-of-acute-exercise-on-university-students-cognitive-performance-in-temperate-and-cold-environments
#16
Ling-Yu Ji, Xiao-Ling Li, Yang Liu, Xiu-Wen Sun, Hui-Fen Wang, Long Chen, Liang Gao
Background: Few studies have examined the acute exercise-induced changes in cognitive performance in different thermal environments and the time course effects. Objective: Investigate the time-dependent effects of acute exercise on university students' processing speed, working memory and cognitive flexibility in temperate and cold environments. Method: Twenty male university students (age 23.5 ± 2.0 years) with moderate physical activity level participated in a repeated-measures within-subjects design. Processing speed, working memory and cognitive flexibility were assessed using CogState test battery at baseline (BASE), followed by a 45-min rest (REST), immediately after (EX) and 30 min after (POST-EX) 30-min moderate-intensity treadmill running in both temperate (TEMP; 25°C) and cold (COLD; 10°C) environments...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28740440/haphop-physio-a-computer-game-to-support-cognitive-therapies-in-children
#17
Carolina Rico-Olarte, Diego M López, Santiago Narváez, Charic D Farinango, Peter S Pharow
BACKGROUND: Care and support of children with physical or mental disabilities are accompanied with serious concerns for parents, families, healthcare institutions, schools, and their communities. Recent studies and technological innovations have demonstrated the feasibility of providing therapy and rehabilitation services to children supported by computer games. OBJECTIVE: The aim of this paper is to present HapHop-Physio, an innovative computer game that combines exercise with fun and learning, developed to support cognitive therapies in children...
2017: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/28736532/a-memory-of-early-life-physical-activity-is-retained-in-bone-marrow-of-male-rats-fed-a-high-fat-diet
#18
Dharani M Sontam, Mark H Vickers, Elwyn C Firth, Justin M O'Sullivan
Studies have reported opposing effects of high-fat (HF) diet and mechanical stimulation on lineage commitment of the bone marrow stem cells. Yet, how bone marrow modulates its gene expression in response to the combined effects of mechanical loading and a HF diet has not been addressed. We investigated whether early-life (before onset of sexual maturity at 6 weeks of age) voluntary physical activity can modulate the effects of a HF diet on male Sprague Dawley rats. In the bone marrow, early-life HF diet resulted in adipocyte hypertrophy and a pro-inflammatory and pro-adipogenic gene expression profile...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28727668/comprehensive-cardiac-rehabilitation-for-secondary-prevention-after-transient-ischemic-attack-or-mild-stroke-psychological-profile-and-outcomes
#19
Peter L Prior, Vladimir Hachinski, Richard Chan, Karen Unsworth, Sharon Mytka, Michael Harnadek, Christina OʼCallaghan, Neville Suskin
PURPOSE: Having previously reported that comprehensive cardiac rehabilitation (CCR) is effective for secondary prevention post-transient ischemic attack (TIA)/mild nondisabling stroke (MNDS), we present psychometric findings for the same sample that elucidate subacute TIA/MNDS psychological outcomes and test whether CCR would be independently associated with psychological improvements. METHODS: In this prospective cohort trial patients with ≥1 risk factor, recruited from a stroke prevention clinic within 12 months (mean = 11...
July 19, 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28724914/enhanced-learning-through-multimodal-training-evidence-from-a-comprehensive-cognitive-physical-fitness-and-neuroscience-intervention
#20
N Ward, E Paul, P Watson, G E Cooke, C H Hillman, N J Cohen, A F Kramer, A K Barbey
The potential impact of brain training methods for enhancing human cognition in healthy and clinical populations has motivated increasing public interest and scientific scrutiny. At issue is the merits of intervention modalities, such as computer-based cognitive training, physical exercise training, and non-invasive brain stimulation, and whether such interventions synergistically enhance cognition. To investigate this issue, we conducted a comprehensive 4-month randomized controlled trial in which 318 healthy, young adults were enrolled in one of five interventions: (1) Computer-based cognitive training on six adaptive tests of executive function; (2) Cognitive and physical exercise training; (3) Cognitive training combined with non-invasive brain stimulation and physical exercise training; (4) Active control training in adaptive visual search and change detection tasks; and (5) Passive control...
July 19, 2017: Scientific Reports
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