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https://www.readbyqxmd.com/read/29775928/tributyltin-impaired-reproductive-success-in-female-zebrafish-through-disrupting-oogenesis-reproductive-behaviors-and-serotonin-synthesis
#1
Wei-Yang Xiao, Ying-Wen Li, Qi-Liang Chen, Zhi-Hao Liu
Tributyltin (TBT), an organotin acting as aromatase (Cyp19a1) inhibitor, has been found to disrupt gametogenesis and reproductive behaviors in several fish species. However, few studies addressing the mechanisms underlying the impaired gametogenesis and reproduction have been reported. In this study, female adults of zebrafish (Danio rerio) were continuously exposed to two nominal concentrations of TBT (100 and 500 ng/L, actual concentrations: 90.8 ± 1.3 ng/L and 470.3 ± 2.7 ng/L, respectively) for 28 days...
May 12, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29775696/tph2-polymorphisms-across-the-spectrum-of-psychiatric-morbidity-a-systematic-review-and-meta-analysis
#2
REVIEW
Koen Willem Ottenhof, Mari Sild, Mélissa Luce Lévesque, Henricus Gerardus Ruhé, Linda Booij
Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in brain serotonin synthesis. The TPH2 gene has frequently been investigated in relation to psychiatric morbidity. The aim of the present review is to integrate results from association studies between TPH2 single nucleotide polymorphisms (SNPs) and various psychiatric disorders, which we furthermore quantified with meta-analysis. We reviewed 166 studies investigating 69 TPH2 SNPs in a broad range of psychiatric disorders, including over 30,000 patients...
May 15, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29730451/the-effects-of-fasting-and-appetite-regulators-on-catecholamine-and-serotonin-synthesis-pathways-in-goldfish-carassius-auratus
#3
Stephanie Mandic, Hélène Volkoff
Monoamine neurotransmitters such as catecholamines [dopamine (DA), norepinephrine (NE) and epinephrine (E)] and serotonin have been shown to influence feeding in vertebrates. In order to better understand the role of monoamine neurotransmitters in the regulation of feeding in fish, we examined the effects of fasting on the brain and intestine gene expression of enzymes involved in their synthesis pathways (SPR: sepiapterin reductase; DHPR: dihydropteridine reductase; TH: tyrosine hydroxylase; TPH: tryptophan hydroxylase; AADC: aromatic l-amino acid decarboxylase; DBH: dopamine β-hydroxylase) in goldfish...
May 3, 2018: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/29723560/associations-between-catecholaminergic-and-serotonergic-genes-and-persistent-breast-pain-phenotypes-following-breast-cancer-surgery
#4
Mitchell R Knisely, Yvette P Conley, Kord M Kober, Betty Smoot, Steven M Paul, Jon D Levine, Christine Miaskowski
Genetic variations in the catecholaminergic and serotonergic pathways may contribute to the development and severity of persistent breast pain. However, investigations of these associations are limited. The purpose of this study was to evaluate for associations between breast pain phenotypes and single nucleotide polymorphisms (SNPs) among 15 genes involved in catecholaminergic and serotonergic neurotransmission. Women rated the presence and intensity of breast pain monthly for six months following breast cancer surgery...
April 30, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29697747/genetic-psychological-and-personal-network-factors-associated-with-changes-in-binge-drinking-over-2-years-among-mexican-heritage-adolescents-in-the-usa
#5
Sunmi Song, Christopher Steven Marcum, Anna V Wilkinson, Sanjay Shete, Laura M Koehly
Background: Despite prevalent binge drinking and alcohol-dependent symptoms among Hispanics, few studies have examined how multidimensional factors influence Hispanic adolescents' binge drinking. Purpose This study examines the effects of genetic, psychological, and social network factors on binge drinking over time among Mexican heritage adolescents in the USA and whether there are correlations among genetic variants that are associated with binge drinking and psychological and network characteristics...
April 24, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/29689343/leveraging-genetics-to-enhance-the-efficacy-of-ptsd-pharmacotherapies
#6
REVIEW
Mark W Miller
Progress in PTSD pharmacotherapy has lagged far behind that of other major mental illnesses. Unfortunately, due to the enormous costs and lengthy process involved in bringing drugs to market, delivering new treatments to patients with PTSD in the near future will remain a challenge. However, by capitalizing on recent advances in the pharmacogenetics of antidepressants, precision psychiatry approaches can be leveraged to optimize the delivery of currently-available medications in a fraction of the time and cost required to develop novel therapeutics...
April 21, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29628275/peripheral-serotonin-synthesis-as-a-new-drug-target
#7
REVIEW
Susann Matthes, Michael Bader
The first step in serotonin (5-HT) biosynthesis is catalyzed by tryptophan hydroxylase (TPH). There are two independent sources of the monoamine that have distinct functions: first, the TPH1-expressing enterochromaffin cells (ECs) of the gut; second, TPH2-expressing serotonergic neurons. TPH1-deficient mice revealed that peripheral 5-HT plays important roles in platelet function and in inflammatory and fibrotic diseases of gut, pancreas, lung, and liver. Therefore, TPH inhibitors were developed which cannot pass the blood-brain barrier to specifically block peripheral 5-HT synthesis...
April 5, 2018: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/29625215/h3k9-acetylation-of-tph2-involved-in-depression-like-behavior-in-male-but-not-female-juvenile-offspring-rat-induced-by-prenatal-stress
#8
Shaokang Dang, Yong Lu, Qian Su, Tianwei Lin, Xiaoxiao Zhang, Huiping Zhang, Junli Zhang, Lin Zhang, Zhongliang Zhu, Hui Li
Increasing evidence has shown that prenatal stress (PS) could cause depression-like behavior in the offspring, which is sex-specific. However, the underlying mechanisms remain to be elucidated. This study is to investigate the involvement of tryptophan hydroxylase 2 (Tph2) H3K9 acetylation (H3K9ac) modification on PS-induced depression-like behavior in juvenile offspring rats (JOR). PS models were established, with or without trichostatin A (TSA) treatment. Animal behavior was assessed by the sucrose preference test (SPT) and forced swimming test (FST)...
April 3, 2018: Neuroscience
https://www.readbyqxmd.com/read/29584766/correction-tph2-female-mice-restore-socio-sexual-recognition-through-upregulating-er%C3%AE-and-otr-genes-in-the-amygdala
#9
Ying Huo, Yaohua Zhang, Huifen Guo, Yingjuan Liu, Qi Fang, Jianxu Zhang
[This corrects the article DOI: 10.1371/journal.pone.0193395.].
2018: PloS One
https://www.readbyqxmd.com/read/29542343/interplay-between-the-key-proteins-of-serotonin-system-in-ssri-antidepressants-efficacy
#10
Alexander V Kulikov, Raul R Gainetdinov, Evgeni Ponimaskin, Allan V Kalueff, Vladimir S Naumenko, Nina K Popova
Selective serotonin reuptake inhibitors (SSRIs) are the most effective and most used antidepressant drugs. Acting by inhibiting serotonin (5-HT) transporter, SSRIs display a typical 3-4-week delay in their therapeutic effects, with nearly 40% of depressed patients remaining treatment-resistant. Recent evidence suggests complex interplay between 5-HT receptors and key proteins of 5-HT metabolism in molecular mechanisms of such delay and resistance to SSRIs. Area covered: This paper concentrates on the interplay between 5-HT receptors in the delay of therapeutic effect of SSRIs, and the interaction between tryptophan hydroxylase 2 and 5-HT transporter in the SSRI resistance...
March 15, 2018: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/29536299/synthesis-and-membrane-transport-of-serotonin-in-the-developing-ovarian-follicle-of-mouse
#11
D A Nikishin, N M Alyoshina, Y B Shmukler
Using RT-PCR, we showed the presence of Tph1 mRNA in follicular cells and Tph2 mRNA in oocytes isolated from primary multilayer ovarian follicles of mouse and the absence of Ddc expression, which indicates that serotonin cannot be synthesized in a developing ovarian follicle. The membrane serotonin transporter Sert is expressed in follicular cells and oocytes. Experiments on the cultivation of follicles in vitro confirmed the absence of serotonin synthesis from 5-hydroxytryptophan and the presence of membrane transport activity in the oocyte...
January 2018: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29520738/tetrahydrobiopterin-treatment-reduces-brain-l-phe-but-only-partially-improves-serotonin-in-hyperphenylalaninemic-enu1-2-mice
#12
Tanja Scherer, Gabriella Allegri, Christineh N Sarkissian, Ming Ying, Hiu Man Grisch-Chan, Anahita Rassi, Shelley R Winn, Cary O Harding, Aurora Martinez, Beat Thöny
Hyperphenylalaninemia (HPA) caused by hepatic phenylalanine hydroxylase (PAH) deficiency has severe consequences on brain monoamine neurotransmitter metabolism. We have studied monoamine neurotransmitter status and the effect of tetrahydrobiopterin (BH4 ) treatment in Pah enu1/enu2 (ENU1/2) mice, a model of partial PAH deficiency. These mice exhibit elevated blood L-phenylalanine (L-Phe) concentrations similar to that of mild hyperphenylalaninemia (HPA), but brain levels of L-Phe are still ~5-fold elevated compared to wild-type...
March 8, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29520369/two-models-of-inescapable-stress-increase-tph2-mrna-expression-in-the-anxiety-related-dorsomedial-part-of-the-dorsal-raphe-nucleus
#13
Nina C Donner, Kenneth H Kubala, James E Hassell, Margaret W Lieb, Kadi T Nguyen, Jared D Heinze, Robert C Drugan, Steven F Maier, Christopher A Lowry
Expression of TPH2, the rate-limiting enzyme for brain serotonin synthesis, is elevated in the dorsal raphe nucleus (DR) of depressed suicide victims. One hypothesis is that this increase in TPH2 expression is stress-induced. Here, we used an established animal model to address whether exposure to an acute stressor, inescapable tail shock (IS), increases tph2 mRNA and Tph2 protein expression, and if IS sensitizes the DR to a subsequent, heterotypic stressor. In Experiment 1 , we measured tph2 mRNA expression 4 h after IS or home cage (HC) control conditions in male rats, using in situ hybridization histochemistry...
February 2018: Neurobiology of Stress
https://www.readbyqxmd.com/read/29484259/poststroke-emotional-disturbances-and-a-tryptophan-hydroxylase-2-gene-polymorphism
#14
Mihye Ko, Smi Choi-Kwon, Sang-Eun Jun, Ju Han Kim, Kyung-Hee Cho, Hyun-Wook Nah, Hasup Song, Jong S Kim
Objectives: Emotional dysfunction is a common finding in stroke patients. Despite reports on serotonergic involvement in the etiology of poststroke emotional dysfunction (PSED), the role of serotonin synthesizing tryptophan hydroxylase 2 (TPH2) genes in the development of PSED remains unclear. Methods: Genotyping of TPH2 rs4641528 and rs10879355 was performed from genomic DNA of 383 stroke patients collected previously and stored at -70°C. Potential associations between TPH 2 genes and poststroke depression (PSD), poststroke emotional incontinence (PSEI), and poststroke anger proneness (PSAP) were investigated 3 months poststroke...
February 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29470551/tph2-female-mice-restore-socio-sexual-recognition-through-upregulating-er%C3%AE-and-otr-genes-in-the-amygdala
#15
Ying Huo, Yaohua Zhang, Huifen Guo, Yingjuan Liu, Qi Fang, Jianxu Zhang
The central 5-hydroxytryptamine system impairs sociosexual behaviors and olfaction preferences in sexually naive mice. However, it remains unknown whether reproductive experiences impart an effect on the sexual olfactory preferences of female mice lacking central serotonin. Here, we aimed at examining such effects and the underlying mechanisms using Tph2 knockout female mice. Sexually naive Tph2-/- female mice failed to recognize olfactory cues regarding sex, genetic relatedness, and social hierarchy despite exhibiting normal olfactory discrimination...
2018: PloS One
https://www.readbyqxmd.com/read/29421749/increased-coiling-frequency-linked-to-apoptosis-in-the-brain-and-altered-thyroid-signaling-in-zebrafish-embryos-danio-rerio-exposed-to-the-pbde-metabolite-6-oh-bde-47
#16
Feng Wang, Mingliang Fang, David E Hinton, Melissa Chernick, Shenglan Jia, Yingdan Zhang, Lingtian Xie, Wenjing Dong, Wu Dong
Polybrominated diphenyl ethers (PBDEs) are a group of brominated flame retardants that are ubiquitously detected in the environment and associated with adverse health outcomes. 6-OH-BDE-47 is a metabolite of the flame retardant, 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47), and there is increasing concern regarding its developmental neurotoxicity and endocrine disrupting properties. In this study, we report that early life exposure in zebrafish (Danio rerio) embryos to 6-OH-BDE-47 (50 and 100 nM) resulted in higher coiling frequency and significantly increased apoptotic cells in the brain...
May 2018: Chemosphere
https://www.readbyqxmd.com/read/29358097/the-effect-of-5-httlpr-and-a-serotonergic-multi-marker-score-on-amygdala-prefrontal-and-anterior-cingulate-cortex-reactivity-and-habituation-in-a-large-healthy-fmri-cohort
#17
J H Piel, T A Lett, C Wackerhagen, M M Plichta, S Mohnke, O Grimm, N Romanczuk-Seiferth, F Degenhardt, H Tost, S Witt, M Nöthen, M Rietschel, A Heinz, A Meyer-Lindenberg, H Walter, S Erk
Major depressive disorder (MDD) is characterized by low mood for at least two weeks. Impaired emotion regulation has been suggested to be the consequence of dysfunctional serotonergic regulation of limbic and prefrontal regions, especially the amygdala, the anterior cingulate cortex (ACC) and the prefrontal cortex (PFC). The impact of genetic variation on brain function can be investigated with intermediate phenotypes. A suggested intermediate phenotype of MDD is emotion recognition: The 5-HTTLPR polymorphism of SLC6A4 as well as other serotonergic genes have been associated with amygdala and prefrontal function during emotion recognition...
March 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29331172/blood-phenylalanine-reduction-corrects-cns-dopamine-and-serotonin-deficiencies-and-partially-improves-behavioral-performance-in-adult-phenylketonuric-mice
#18
Shelley R Winn, Tanja Scherer, Beat Thöny, Ming Ying, Aurora Martinez, Sydney Weber, Jacob Raber, Cary O Harding
Central nervous system (CNS) deficiencies of the monoamine neurotransmitters dopamine and serotonin have been implicated in the pathophysiology of neuropsychiatric dysfunction in human phenylketonuria (PKU). In this study, we confirmed the occurrence of brain dopamine and serotonin deficiencies in association with severe behavioral alterations and cognitive impairments in hyperphenylalaninemic C57BL/6-Pahenu2/enu2 mice, a model of human PKU. Phenylalanine-reducing treatments, including either dietary phenylalanine restriction or liver-directed gene therapy, initiated during adulthood were associated with increased brain monoamine content along with improvements in nesting behavior but without a change in the severe cognitive deficits exhibited by these mice...
January 2018: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29314569/association-between-single-nucleotide-polymorphisms-of-tph1-and-tph2-genes-and-depressive-disorders
#19
Paulina Wigner, Piotr Czarny, Ewelina Synowiec, Michał Bijak, Katarzyna Białek, Monika Talarowska, Piotr Galecki, Janusz Szemraj, Tomasz Sliwinski
Tryptophan catabolites pathway disorders are observed in patients with depression. Moreover, single nucleotide polymorphisms of tryptophan hydroxylase genes may modulate the risk of depression occurrence. The objective of our study was to confirm the association between the presence of polymorphic variants of TPH1 and TPH2 genes, and the development of depressive disorders. Six polymorphisms were selected: c.804-7C>A (rs10488682), c.-1668T>A (rs623580), c.803+221C>A (rs1800532), c.-173A>T (rs1799913)-TPH1, c...
March 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29174640/dorsal-raph%C3%A3-nucleus-glucocorticoid-receptors-inhibit-tph2-gene-expression-in-male-c57bl-6j-mice
#20
Melanie Y Vincent, Nina C Donner, David G Smith, Christopher A Lowry, Lauren Jacobson
The serotonergic dorsal raphé nucleus (DRN) expresses glucocorticoid receptors (GR), and systemic glucocorticoids have been shown to regulate expression and activity of tryptophan hydroxylase isoform 2, the rate-limiting enzyme for serotonin synthesis in brain. We have used intra-DRN injection of pseudotyped adeno-associated virus AAV2/9 transducing either green fluorescent protein (GFP control) or Cre recombinase (DRN GR deletion) in floxed GR mice to determine if DRN GR directly regulate DRN mRNA levels of tryptophan hydroxylase 2 (tph2)...
February 5, 2018: Neuroscience Letters
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