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Yena Lee

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https://www.readbyqxmd.com/read/28068459/does-pharmacogenomic-testing-improve-clinical-outcomes-for-major-depressive-disorder-a-systematic-review-of-clinical-trials-and-cost-effectiveness-studies
#1
Joshua D Rosenblat, Yena Lee, Roger S McIntyre
OBJECTIVE: Pharmacogenomic testing has become scalable and available to the general public. Pharmacogenomics has shown promise for predicting antidepressant response and tolerability in the treatment of major depressive disorder (MDD). In theory, pharmacogenomics can improve clinical outcomes by guiding antidepressant selection and dosing. The current systematic review examines the extant literature to determine the impact of pharmacogenomic testing on clinical outcomes in MDD and assesses its cost-effectiveness...
January 3, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28044944/a-pragmatic-approach-to-the-diagnosis-and-treatment-of-mixed-features-in-adults-with-mood-disorders
#2
Roger S McIntyre, Yena Lee, Rodrigo B Mansur
Mixed features specifier (MFS) is a new nosological entity defined and operationalized in the Diagnostic and Statistical Manual of Mental Disorders (DSM), 5th Edition. The impetus to introduce the MFS and supplant mixed states was protean, including the lack of ecological validity, high rates of misdiagnosis, and guideline discordant treatment for mixed states. Mixed features specifier identifies a phenotype in psychiatry with greater illness burden, as evidenced by earlier age at onset, higher episode frequency and chronicity, psychiatric and medical comorbidity, suicidality, and suboptimal response to conventional antidepressants...
December 2016: CNS Spectrums
https://www.readbyqxmd.com/read/27935809/assessing-and-measuring-cognitive-function-in-major-depressive-disorder
#3
Renee-Marie Ragguett, Danielle S Cha, Ron Kakar, Joshua D Rosenblat, Yena Lee, Roger S McIntyre
Cognitive dysfunction is a major component of major depressive disorder (MDD). No 'gold-standard' tool exists for the assessment of cognitive dysfunction for adults with MDD. The use of measurement-based care to improve treatment outcomes invites the need for a systematic screening, evaluation and measurement tool. The aim herein was to provide a succinct summary of literature documenting clinical implication of cognitive dysfunction in MDD, and a review of available screening, diagnostic and measurement tools for cognitive dysfunction in MDD is provided...
November 2016: Evidence-based Mental Health
https://www.readbyqxmd.com/read/27913990/sirukumab-a-potential-treatment-for-mood-disorders
#4
REVIEW
Aileen J Zhou, Yena Lee, Giacomo Salvadore, Benjamin Hsu, Trehani M Fonseka, Sidney H Kennedy, Roger S McIntyre
Convergent evidence indicates that abnormalities in the innate immune system may be pertinent to the pathogenesis, phenomenology, and possible treatment of several mental disorders. In keeping with this view, the targeting of interleukin-6 with the human monoclonal antibody sirukumab may represent a possible treatment and disease modification approach, for adults with brain-based disorders (e.g., major depressive disorder). A PubMed/Medline database search was performed using the following search terms: sirukumab; anti-IL-6; IL-6; major depressive disorder; inflammation...
January 2017: Advances in Therapy
https://www.readbyqxmd.com/read/27810270/the-association-between-insulin-resistance-and-depression-in-the-korean-general-population
#5
Jae-Hon Lee, Sung Keun Park, Jae-Hong Ryoo, Chang-Mo Oh, Rodrigo B Mansur, Jeffrey E Alfonsi, Danielle S Cha, Yena Lee, Roger S McIntyre, Ju Young Jung
BACKGROUND: Previous studies showed that the insulin resistance (IR) could be related to depression. However, this association is still equivocal in the general population. Herein, we aimed to investigate the association between IR and depressive symptoms in a large sample in South Korea. METHODS: A cross-sectional study was carried out for 165,443 Korean men and women who received a health checkup including various clinical parameters and the Center for Epidemiologic Studies Depression scales (CES-D)...
January 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27783998/hepatocellular-carcinoma-and-antidepressants-a-nationwide-population-based-study
#6
Vincent Chin-Hung Chen, Chiao-Fan Lin, Yi-Hsuan Hsieh, Hsin-Yi Liang, Kuo-You Huang, Wei-Che Chiu, Yena Lee, Roger S McIntyre, Hsiang-Lin Chan
Hepatocellular carcinoma (HCC) is highly prevalent in Asia. Antidepressants have been associated with increase in hepatocellular carcinoma. This is the first Asian population-based study to evaluate the association between antidepressant use and risk of HCC. Based on Taiwan's National Health Insurance Research Database, we conducted a nationwide population-based study. A total of 49,998 cases with HCC were identified and paired with 244,236 randomly selected controls. The data was analyzed via the conditional logistic regression model adjusting for several confounding factors...
October 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27744223/antidepressants-and-colorectal-cancer-a-population-based-nested-case-control-study
#7
Hsiu-Chiung Lee, Wei-Che Chiu, Tsu-Nai Wang, Yin-To Liao, I-Chia Chien, Yena Lee, Roger S McIntyre, Pau-Chung Chen, Vincent Chin-Hung Chen
BACKGROUND: Experimental evidence indicates that serotonin is associated with both proliferative and pro-carcinogenic effects on colorectal tumors. The present study aims to investigate the associations between antidepressant use and colorectal cancer in an epidemiological sample. METHODS: We conducted a population-based case-control study utilizing Taiwan's National Health Insurance Research Database (NHIRD). We identified 49,342 cases with colorectal cancer and 240,985 controls between 1997 and 2008...
October 1, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27498907/the-interface-of-depression-and-obesity
#8
REVIEW
Nattinee Jantaratnotai, Kanokwan Mosikanon, Yena Lee, Roger S McIntyre
Depression and obesity are both highly prevalent and are leading public health problems. These foregoing disorders independently have great impact on morbidity and mortality affecting patients' health and well-being as well as on the socioeconomic aspect of functional impairment and healthcare expenditure. Results from epidemiological studies, clinical trials and recent meta-analyses support the association between mood disorders and obesity as both frequently co-occur in all races of populations examined. It is now well-established through longitudinal studies that obesity is a risk factor for mood disorders and vice versa...
August 4, 2016: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/27442640/endometrial-cancer-and-antidepressants-a-nationwide-population-based-study
#9
Chiao-Fan Lin, Hsiang-Lin Chan, Yi-Hsuan Hsieh, Hsin-Yi Liang, Wei-Che Chiu, Kuo-You Huang, Yena Lee, Roger S McIntyre, Vincent Chin-Hung Chen
To our knowledge, the association between antidepressant exposure and endometrial cancer has not been previously explored. Herein, we aim to investigate the association between antidepressant prescription, including novel antidepressants, and the risk for endometrial cancer in a population-based study.Data for the analysis were derived from National Health Insurance Research Database. We identified 8392 cases with a diagnosis of endometrial cancer and 82,432 matched controls. A conditional logistic regression model was used, with adjusting for potentially confounding variables (e...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27423425/assessment-of-abnormal-brain-structures-and-networks-in-major-depressive-disorder-using-morphometric-and-connectome-analyses
#10
Vincent Chin-Hung Chen, Chao-Yu Shen, Sophie Hsin-Yi Liang, Zhen-Hui Li, Yeu-Sheng Tyan, Yin-To Liao, Yin-Chen Huang, Yena Lee, Roger S McIntyre, Jun-Cheng Weng
BACKGROUND: It is hypothesized that the phenomenology of major depressive disorder (MDD) is subserved by disturbances in the structure and function of brain circuits; however, findings of structural abnormalities using MRI have been inconsistent. Generalized q-sampling imaging (GQI) methodology provides an opportunity to assess the functional integrity of white matter tracts in implicated circuits. METHODS: The study population was comprised of 16 outpatients with MDD (mean age 44...
November 15, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27347362/the-prevalence-and-clinical-characteristics-associated-with-diagnostic-and-statistical-manual-version-5-defined-anxious-distress-specifier-in-adults-with-major-depressive-disorder-results-from-the-international-mood-disorders-collaborative-project
#11
Roger S McIntyre, Hanna O Woldeyohannes, Joanna K Soczynska, Maj Vinberg, Danielle S Cha, Yena Lee, Laura A Gallaugher, Roman S Dale, Mohammad T Alsuwaidan, Rodrigo B Mansur, David J Muzina, Andre Carvalho, Sidney Kennedy
OBJECTIVES: The aim of the study was to evaluate the prevalence of and illness characteristics in adults with major depressive disorder (MDD) with anxious distress specifier (ADS) enrolled in the International Mood Disorders Collaborative Project, which is a collaborative research platform at the Mood Disorders Psychopharmacology Unit, University of Toronto, Canada and the Cleveland Clinic, Cleveland, Ohio, USA. METHODS: Data from participants who met criteria for a current major depressive episode as part of MDD (n = 830) were included in this post hoc analysis...
May 2016: Therapeutic Advances in Chronic Disease
https://www.readbyqxmd.com/read/27108484/micro-precise-spatiotemporal-delivery-system-embedded-in-3d-printing-for-complex-tissue-regeneration
#12
Solaiman Tarafder, Alia Koch, Yena Jun, Conrad Chou, Mary R Awadallah, Chang H Lee
Three dimensional (3D) printing has emerged as an efficient tool for tissue engineering and regenerative medicine, given its advantages for constructing custom-designed scaffolds with tunable microstructure/physical properties. Here we developed a micro-precise spatiotemporal delivery system embedded in 3D printed scaffolds. PLGA microspheres (μS) were encapsulated with growth factors (GFs) and then embedded inside PCL microfibers that constitute custom-designed 3D scaffolds. Given the substantial difference in the melting points between PLGA and PCL and their low heat conductivity, μS were able to maintain its original structure while protecting GF's bioactivities...
April 25, 2016: Biofabrication
https://www.readbyqxmd.com/read/27082591/association-of-tic-disorders-and-enterovirus-infection-a-nationwide-population-based-study
#13
Ching-Shu Tsai, Yao-Hsu Yang, Kuo-You Huang, Yena Lee, Roger S McIntyre, Vincent Chin-Hung Chen
There has been growing interest in the association between infectious disease and mental disorders, but an association between enterovirus (EV) infection and tic disorders has not been sufficiently explored. Herein, we aim to investigate the association between EV infection and incidence of tic disorders in a nationwide population-based sample using Taiwan's National Health Insurance Research Database. We identified individuals aged ≤18 years prior to 2005 with an inpatient diagnosis of EV infection and/or history of EV infection...
April 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26922935/long-term-effects-of-diesel-exhaust-particles-on-airway-inflammation-and-remodeling-in-a-mouse-model
#14
Byeong Gon Kim, Pureun Haneul Lee, Shin Hwa Lee, Young En Kim, Mee Yong Shin, Yena Kang, Seong Hwan Bae, Min Jung Kim, Taiyoun Rhim, Choon Sik Park, An Soo Jang
PURPOSE: Diesel exhaust particles (DEPs) can induce and trigger airway hyperresponsiveness (AHR) and inflammation. The aim of this study was to investigate the effect of long-term DEP exposure on AHR, inflammation, lung fibrosis, and goblet cell hyperplasia in a mouse model. METHODS: BALB/c mice were exposed to DEPs 1 hour a day for 5 days a week for 3 months in a closed-system chamber attached to a ultrasonic nebulizer (low dose: 100 μg/m³ DEPs, high dose: 3 mg/m³ DEPs)...
May 2016: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/26919287/effect-of-pleurotus-eryngii-mushroom-%C3%AE-glucan-on-quality-characteristics-of-common-wheat-pasta
#15
SunHee Kim, Jo-Won Lee, Yena Heo, BoKyung Moon
The objective of this study was to evaluate the effect of β-glucan-rich fractions (BGRFs) from Pleurotus eryngii mushroom powder on the quality, textural properties, and sensory evaluation of common wheat pasta. Pasta was prepared from semolina flour and common wheat flour by replacing common wheat flour at 2%, 4%, and 6% with BGRFs. Semolina flour showed significantly higher viscosities than common wheat flour samples. However, all viscosities, except the breakdown viscosity, were reduced with increasing percentages of BGRFs...
April 2016: Journal of Food Science
https://www.readbyqxmd.com/read/26799639/ultrathin-free-standing-ternary-alloy-nanosheets
#16
Jong Wook Hong, Yena Kim, Dae Han Wi, Seunghoon Lee, Su-Un Lee, Young Wook Lee, Sang-Il Choi, Sang Woo Han
A synthesis strategy for the preparation of ultrathin free-standing ternary-alloy nanosheets is reported. Ultrathin Pd-Pt-Ag nanosheets with a thickness of approximately 3 nm were successfully prepared by co-reduction of the metal precursors in an appropriate molar ratio in the presence of CO. Both the presence of CO and the interplay between the constituent metals provide fine control over the anisotropic two-dimensional growth of the ternary-alloy nanostructure. The prepared Pd-Pt-Ag nanosheets were superior catalysts of ethanol electrooxidation owing to their specific structural and compositional characteristics...
February 18, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/26714651/anhedonia-and-cognitive-function-in-adults-with-mdd-results-from-the-international-mood-disorders-collaborative-project
#17
Roger S McIntyre, Hanna O Woldeyohannes, Joanna K Soczynska, Nadia A Maruschak, Ida K Wium-Andersen, Maj Vinberg, Danielle S Cha, Yena Lee, Holly X Xiao, Laura Ashley Gallaugher, Roman M Dale, Mohammad T Alsuwaidan, Rodrigo B Mansur, David J Muzina, Andre F Carvalho, Jeanette M Jerrell, Sidney H Kennedy
BACKGROUND: Cognitive dysfunction is common in major depressive disorder (MDD) and a critical determinant of health outcome. Anhedonia is a criterion item toward the diagnosis of a major depressive episode (MDE) and a well-characterized domain in MDD. We sought to determine the extent to which variability in self-reported cognitive function correlates with anhedonia. METHOD: A post hoc analysis was conducted using data from (N=369) participants with a Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR)-defined diagnosis of MDD who were enrolled in the International Mood Disorders Collaborative Project (IMDCP) between January 2008 and July 2013...
December 30, 2015: CNS Spectrums
https://www.readbyqxmd.com/read/26683526/treating-to-target-in-major-depressive-disorder-response-to-remission-to-functional-recovery
#18
REVIEW
Roger S McIntyre, Yena Lee, Rodrigo B Mansur
Treating to target in chronic diseases [e.g. Major Depressive Disorder (MDD)] fosters precision, consistency, and appropriateness of treatment selection and sequencing. Therapeutic target definitions/endpoints in MDD should satisfy patient-, provider-, and societal expectations. Functional recovery in depression and return to both physical and mental health are the overarching therapeutic objectives. Treating to target in MDD implies multidimensional symptomatic remission, with a particular emphasis on cognitive function and aspects of positive mental health...
December 2015: CNS Spectrums
https://www.readbyqxmd.com/read/26658082/a-new-perspective-on-the-anti-suicide-effects-with-ketamine-treatment-a-procognitive-effect
#19
REVIEW
Yena Lee, Kahlood Syeda, Nadia A Maruschak, Danielle S Cha, Rodrigo B Mansur, Ida K Wium-Andersen, Hanna O Woldeyohannes, Joshua D Rosenblat, Roger S McIntyre
Available evidence indicates that a single, low-dose administration of ketamine is a robust, rapid-onset intervention capable of mitigating depressive symptoms in adults with treatment-resistant mood disorders. Additional evidence also suggests that ketamine may offer antisuicide effects. Herein, we propose that the antidepressant effects reported with ketamine administration are mediated, in part, by targeting neural circuits that subserve cognitive processing relevant to executive function and cognitive emotional processing...
February 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/26606417/antidepressants-and-gastric-cancer-a-nationwide-population-based-nested-case-control-study
#20
Yi-Hsuan Hsieh, Wei-Che Chiu, Chiao-Fan Lin, Hsiang-Lin Chan, Hsin-Yi Liang, Yena Lee, Roger S McIntyre, Vincent Chin-Hung Chen
BACKGROUND: To our knowledge, no epidemiological study has reported on whether an association between antidepressant exposure and gastric cancer exists. Herein, we aim to investigate the possible association between antidepressant exposure and gastric cancer incidence. METHODS: Using a nested case-control design, we identified 26289 cases with gastric cancer and 127984 controls from Taiwan's National Health Insurance Research Database (NHIRD). The data were analyzed using a conditional logistic regression model adjusting for possible confounding variables...
2015: PloS One
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