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https://www.readbyqxmd.com/read/28104946/mobious-syndrome-mr-findings
#1
Maskal Revanna Srinivas, Dhulappa Mudabasappagol Vaishali, Kadaba Shamachar Vedaraju, Bangalore Rangaswamy Nagaraj
Möbius syndrome is an extremely rare congenital disorder. We report a case of Möbius syndrome in a 2-year-old girl with bilateral convergent squint and left-sided facial weakness. The characteristic magnetic resonance imaging (MRI) findings of Möbius syndrome, which include absent bilateral abducens nerves and absent left facial nerve, were noted. In addition, there was absence of left anterior inferior cerebellar artery (AICA) and absence of bilateral facial colliculi. Clinical features, etiology, and imaging findings are discussed...
October 2016: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28076777/antagonistic-functions-of-mbp-and-cnp-establish-cytosolic-channels-in-cns-myelin
#2
Nicolas Snaidero, Caroline Velte, Matti Myllykoski, Arne Raasakka, Alexander Ignatev, Hauke B Werner, Michelle S Erwig, Wiebke Möbius, Petri Kursula, Klaus-Armin Nave, Mikael Simons
The myelin sheath is a multilamellar plasma membrane extension of highly specialized glial cells laid down in regularly spaced segments along axons. Recent studies indicate that myelin is metabolically active and capable of communicating with the underlying axon. To be functionally connected to the neuron, oligodendrocytes maintain non-compacted myelin as cytoplasmic nanochannels. Here, we used high-pressure freezing for electron microscopy to study these cytoplasmic regions within myelin close to their native state...
January 10, 2017: Cell Reports
https://www.readbyqxmd.com/read/28048620/su-f-t-308-mobius-fx-evaluation-and-comparison-against-a-commercial-4d-detector-array-for-vmat-plan-qa
#3
L Vazquez Quino, C Huerta Hernandez, A Morrow, B Massingill, D Rangaraj
PURPOSE: To evaluate the use of MobiusFX as a pre-treatment verification IMRT QA tool and compare it with a commercial 4D detector array for VMAT plan QA. METHODS: 15 VMAT plan QA of different treatment sites were delivered and measured by traditional means with the 4D detector array ArcCheck (Sun Nuclear corporation) and at the same time measurement in linac treatment logs (Varian Dynalogs files) were analyzed from the same delivery with MobiusFX software (Mobius Medical Systems)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048548/su-a-brc-02-the-path-of-a-chief-of-medical-physics
#4
D Shepard
: This year's Annual Student Meeting consists of a panel of professionals who have pursued a traditional education in medical physics and have since pursued a variety of careers. These range from chief medical physicist, small business founder, FDA scientist, industry R&D scientist, and academic researcher. Each panelist will discuss their education, positions that they have held leading to their current one, and factors that influenced them to pursue their careers. Time will be left at the end of the talk to open the floor for questions from students and trainees...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048368/su-a-brc-05-the-path-of-a-fda-physicist
#5
R Ochs
: This year's Annual Student Meeting consists of a panel of professionals who have pursued a traditional education in medical physics and have since pursued a variety of careers. These range from chief medical physicist, small business founder, FDA scientist, industry R&D scientist, and academic researcher. Each panelist will discuss their education, positions that they have held leading to their current one, and factors that influenced them to pursue their careers. Time will be left at the end of the talk to open the floor for questions from students and trainees...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047961/su-f-t-285-evaluation-of-a-patient-dvh-based-imrt-qa-system
#6
H Zhen, G Redler, J Chu, J Turian
PURPOSE: To evaluate the clinical performance of a patient DVH-based QA system for prostate VMAT QA. METHODS: Mobius3D(M3D) is a QA software with an independent beam model and dose engine. The MobiusFX(MFX) add-on predicts patient dose using treatment machine log files. We commissioned the Mobius beam model in two steps. First, the stock beam model was customized using machine commissioning data, then verified against the TPS with 12 simple phantom plans and 7 clinical 3D plans...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047951/tu-h-campus-tep1-04-novel-3d-printed-plastic-cutouts-filled-with-aluminum-oxide-for-same-day-electron-radiotherapy
#7
J Mikell, C Lee, K Lam
PURPOSE: Clinics that outsource electron cutout manufacturing may be unable to simulate and treat patients on the same day. To enable same day treatment, we investigate the use of 3D printed hollow cutouts filled with 30 grit Al2 O3 powder. We verified the dosimetric equivalence of such a cutout relative to an outsourced Copper cutout. METHODS: Printing was performed using a Ultibots Kossel 250 V-Slot 3D printer and polylactic acid filament. Printing files were derived from an in-house 3D model designed to mate with a Varian 6 cm electron cone...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047886/su-a-brc-03-the-path-of-a-small-business-owner
#8
N Childress
: This year's Annual Student Meeting consists of a panel of professionals who have pursued a traditional education in medical physics and have since pursued a variety of careers. These range from chief medical physicist, small business founder, FDA scientist, industry R&D scientist, and academic researcher. Each panelist will discuss their education, positions that they have held leading to their current one, and factors that influenced them to pursue their careers. Time will be left at the end of the talk to open the floor for questions from students and trainees...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047722/su-a-brc-06-the-path-of-an-academic-physicist
#9
R Howell
: This year's Annual Student Meeting consists of a panel of professionals who have pursued a traditional education in medical physics and have since pursued a variety of careers. These range from chief medical physicist, small business founder, FDA scientist, industry R&D scientist, and academic researcher. Each panelist will discuss their education, positions that they have held leading to their current one, and factors that influenced them to pursue their careers. Time will be left at the end of the talk to open the floor for questions from students and trainees...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047241/su-f-t-306-validation-of-mobius-3d-and-fx-for-elekta-linear-accelerators
#10
C Nelson, M Garcia, E Calderon, S Kirsner
PURPOSE: Log file based IMRT and VMAT QA is a system that analyzes treatment log files and uses delivery parameters to compute the dose to the patient/phantom. This system was previously commissioned for Varian machines, the purpose of this work is to describe the process for commissioning Mobius for use with Elekta machines. METHODS: Twelve IMRT and VMAT plans (6×) were planned and delivered and dose was measured using MapCheck, the results were compared to that computed by Mobius...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047222/su-a-brc-04-the-path-of-a-research-and-development-physicist
#11
K Ruchala
: This year's Annual Student Meeting consists of a panel of professionals who have pursued a traditional education in medical physics and have since pursued a variety of careers. These range from chief medical physicist, small business founder, FDA scientist, industry R&D scientist, and academic researcher. Each panelist will discuss their education, positions that they have held leading to their current one, and factors that influenced them to pursue their careers. Time will be left at the end of the talk to open the floor for questions from students and trainees...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047147/su-a-brc-00-aapm-medical-physics-student-meeting-the-many-paths-of-medical-physics
#12
Alison Roth
: This year's Annual Student Meeting consists of a panel of professionals who have pursued a traditional education in medical physics and have since pursued a variety of careers. These range from chief medical physicist, small business founder, FDA scientist, industry R&D scientist, and academic researcher. Each panelist will discuss their education, positions that they have held leading to their current one, and factors that influenced them to pursue their careers. Time will be left at the end of the talk to open the floor for questions from students and trainees...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047074/su-a-brc-07-q-a
#13
A Roth
: This year's Annual Student Meeting consists of a panel of professionals who have pursued a traditional education in medical physics and have since pursued a variety of careers. These range from chief medical physicist, small business founder, FDA scientist, industry R&D scientist, and academic researcher. Each panelist will discuss their education, positions that they have held leading to their current one, and factors that influenced them to pursue their careers. Time will be left at the end of the talk to open the floor for questions from students and trainees...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046939/su-g-tep4-11-implementation-of-a-non-measurement-based-patient-specific-imrt-qa-program
#14
S Chen, M Guerrero, B Zhang, B Yi, S Mossahebi, K Prado, W D'Souza, K Langen
PURPOSE: To implement a comprehensive non-measurement-based verification program for patient-specific IMRT QA METHODS: Based on published guidelines, a robust IMRT QA program should assess the following components: 1) accuracy of dose calculation, 2) accuracy of data transfer from the treatment planning system (TPS) to the record-and-verify (RV) system, 3) treatment plan deliverability, and 4) accuracy of plan delivery. RESULTS: We have implemented an IMRT QA program that consist of four components: 1) an independent re-calculation of the dose distribution in the patient anatomy with a commercial secondary dose calculation program: Mobius3D (Mobius Medical Systems, Houston, TX), with dose accuracy evaluation using gamma analysis, PTV mean dose, PTV coverage to 95%, and organ-at-risk mean dose; 2) an automated in-house-developed plan comparison system that compares all relevant plan parameters such as MU, MLC position, beam iso-center position, collimator, gantry, couch, field size settings, and bolus placement, etc...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046485/su-a-brc-01-welcome-and-introduction-to-student-and-trainees-day
#15
A Roth
: This year's Annual Student Meeting consists of a panel of professionals who have pursued a traditional education in medical physics and have since pursued a variety of careers. These range from chief medical physicist, small business founder, FDA scientist, industry R&D scientist, and academic researcher. Each panelist will discuss their education, positions that they have held leading to their current one, and factors that influenced them to pursue their careers. Time will be left at the end of the talk to open the floor for questions from students and trainees...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046481/su-f-t-440-the-feasibility-research-of-checking-cervical-cancer-imrt-pre-treatment-dose-verification-by-automated-treatment-planning-verification-system
#16
X Liu, Y Yin, X Lin
PURPOSE: To assess the preliminary feasibility of automated treatment planning verification system in cervical cancer IMRT pre-treatment dose verification. METHODS: The study selected randomly clinical IMRT treatment planning data for twenty patients with cervical cancer, all IMRT plans were divided into 7 fields to meet the dosimetric goals using a commercial treatment planning system(PianncleVersion 9.2and the EclipseVersion 13.5). The plans were exported to the Mobius 3D (M3D)server percentage differences of volume of a region of interest (ROI) and dose calculation of target region and organ at risk were evaluated, in order to validate the accuracy automated treatment planning verification system...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046202/intracerebral-injections-and-ultrastructural-analysis-of-high-pressure-frozen-brain-tissue
#17
Marie-Theres Weil, Torben Ruhwedel, Wiebke Möbius, Mikael Simons
Intracerebral injections are an invasive method to bypass the blood brain barrier and are widely used to study molecular and cellular mechanisms of the central nervous system. The administered substances are injected directly at the site of interest, executing their effect locally. By combining injections in the rat brain with state-of-the-art electron microscopy, subtle changes in ultrastructure of the nervous tissue can be detected prior to overt damage or disease. The protocol presented here involves stereotactic injection into the corpus callosum of Lewis rats and the cryopreparation of freshly dissected tissue for electron microscopy...
January 3, 2017: Current Protocols in Neuroscience
https://www.readbyqxmd.com/read/28033002/smaragdyrins-and-sapphyrins-analogues
#18
Tamal Chatterjee, A Srinivasan, Mangalampalli Ravikanth, Tavarakere K Chandrashekar
Porphyrins and expanded porphyrins have attracted the attention of chemists for a long time in view of their diverse applications in catalysis; as anion, cation, and neutral substrate receptors; as ligands to coordinate large metal ions; as nonlinear optical materials, MRI contrasting agents, and sensitizers for photodynamic therapy (PDT); and more recently as models for aromaticity (both Hückel and Möbius). A diverse range of synthetic expanded porphyrins containing up to 96π electrons have been reported, and their properties have been exploited for various applications...
December 29, 2016: Chemical Reviews
https://www.readbyqxmd.com/read/28028937/stable-non-fused-22-pentaphyrins-and-a-fused-24-pentaphyrin-displaying-crystal-polymorphism-between-h%C3%A3-ckel-and-m%C3%A3-bius-structures
#19
Tomoki Yoneda, Tyuji Hoshino, Saburo Neya
Partially β-substituted and meso-tetrakis(pentafluorophenyl)-substituted [22]pentaphyrins 11 and 12 were synthesized by acid-catalyzed condensation of a meso-C6 F5 -substituted tripyrrane dicarbinol with β-alkylated dipyrromethanes. These [22]pentaphyrins are stable, allowing their characterization by NMR and UV/Vis spectroscopies, and X-ray crystallography, and display strong aromaticity due to 22π-electronic circuits. In methanol, β,β-diethoxycarbonylated pentaphyrin 12 underwent an N-fusion reaction to give N-fused pentaphyrin 13, which exhibits crystal polymorphism between Hückel and Möbius structures, depending upon the recrystallization solvent...
December 28, 2016: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28009046/single-step-purification-of-cyclotides-using-affinity-chromatography
#20
Shaikh Jamal Uddin, Taj Muhammad, Md Shafiullah, Blazej Slazak, Razina Rouf, Ulf Göransson
Cyclotides are considered promising scaffolds for drug development owing to their inherent host defence activities and highly stable structure, defined by the cyclic cystine knot. These proteins are expressed as complex mixtures in plants. Although several methods have been developed for their isolation and analysis, purification of cyclotides is still a lengthy process. Here, we describe the use of affinity chromatography for the purification of cyclotides using polyclonal IgG antibodies raised in rabbits against cycloviolacin O2 and immobilized on NHS-activated Sepharose columns...
December 23, 2016: Biopolymers
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