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https://www.readbyqxmd.com/read/28345573/clinical-correlation-of-imaging-findings-in-congenital-cranial-dysinnervation-disorders-involving-abducens-nerve
#1
Chanchal Gupta, Pradeep Sharma, Rohit Saxena, Ajay Garg, Sanjay Sharma
PURPOSE: High-resolution magnetic resonance imaging (MRI) of intracranial parts of sixth nerve and seventh nerve and the extraocular muscles (EOMs) in orbit to correlate the clinical characteristics in patients with two special forms of strabismus in congenital cranial dysinnervation disorders which are Duane's retraction syndrome (DRS) and Mobius syndrome. MATERIALS AND METHODS: Morphological analysis by 3T MRI of orbit (using surface coils) and brain (using 32 channel head coil) was performed on 6 patients with clinical DRS (1 bilateral), 2 cases with Mobius syndrome, and 1 case with congenital sixth nerve palsy...
February 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28337123/analysis-of-the-serotonergic-system-in-a-mouse-model-of-rett-syndrome-reveals-unusual-upregulation-of-serotonin-receptor-5b
#2
Steffen Vogelgesang, Sabine Niebert, Ute Renner, Wiebke Möbius, Swen Hülsmann, Till Manzke, Marcus Niebert
Mutations in the transcription factor methyl-CpG-binding-protein 2 (MeCP2) cause a delayed-onset neurodevelopmental disorder known as Rett syndrome (RTT). Although alteration in serotonin levels have been reported in RTT patients, the molecular mechanisms underlying these defects are not well understood. Therefore, we chose to investigate the serotonergic system in hippocampus and brainstem of male Mecp2(-/y) knock-out mice in the B6.129P2(C)-Mecp2(tm1.1Bird) mouse model of RTT. The serotonergic system in mouse is comprised of 16 genes, whose mRNA expression profile was analyzed by quantitative RT-PCR...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28295698/metallapentalenofurans-and-lactone-fused-metallapentalynes
#3
Zhengyu Lu, Congqing Zhu, Yuanting Cai, Jun Zhu, Yuhui Hua, Zhixin Chen, Jiangxi Chen, Haiping Xia
Metalla-aromatics are attractive species because they exhibit the properties of both organometallics and aromatics. Reported metal-bridged polycyclic aromatic complexes, as well as Möbius aromatic species, are still rare. Herein, we present the construction of two new metal-bridged polycyclic aromatic frameworks, α-metallapentalenofurans and lactone-fused metallapentalynes, by the reactions of osmapentalyne with terminal aryl alkynes in the presence of H2O or HBF4/H2O, respectively. DFT calculations show that the α-metallapentalenofurans possess rare planar Craig-type Möbius aromaticity derived from the 11-center-12-electron dπ-pπ π-conjugation...
March 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28291938/validation-of-a-modern-second-check-dosimetry-system-using-a-novel-verification-phantom
#4
Daniel G McDonald, Dustin J Jacqmin, Christopher J Mart, Nicholas C Koch, Jean L Peng, Michael S Ashenafi, Mario A Fugal, Kenneth N Vanek
PURPOSE: To evaluate the Mobius second-check dosimetry system by comparing it to ionization-chamber dose measurements collected in the recently released Mobius Verification Phantom™ (MVP). For reference, a comparison of these measurements to dose calculated in the primary treatment planning system (TPS), Varian Eclipse with the AcurosXB dose algorithm, is also provided. Finally, patient dose calculated in Mobius is compared directly to Eclipse to demonstrate typical expected results during clinical use of the Mobius system...
January 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28284609/evaluation-of-associations-between-genotypes-of-mycobacterium-avium-subsp-paratuberculsis-and-presence-of-intestinal-lesions-characteristic-of-paratuberculosis
#5
Petra Möbius, Elisabeth Liebler-Tenorio, Martin Hölzer, Heike Köhler
Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of paratuberculosis affecting ruminants worldwide. Depending on the MAP-Type (MAP-C or MAP-S, cattle or sheep type), strains differ in virulence and host preference. There is not yet any strong evidence indicating that individual field strains of the same MAP-subgroup exhibit differences in virulence. The aim of this study was to evaluate a potential association between the genotype of individual field strains belonging to the MAP-C group and the presence of macroscopic intestinal lesions characteristic of paratuberculosis in the infected animals...
March 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28254827/the-micos-component-mic60-displays-a-conserved-membrane-bending-activity-that-is-necessary-for-normal-cristae-morphology
#6
Daryna Tarasenko, Mariam Barbot, Daniel C Jans, Benjamin Kroppen, Boguslawa Sadowski, Gudrun Heim, Wiebke Möbius, Stefan Jakobs, Michael Meinecke
The inner membrane (IM) of mitochondria displays an intricate, highly folded architecture and can be divided into two domains: the inner boundary membrane adjacent to the outer membrane and invaginations toward the matrix, called cristae. Both domains are connected by narrow, tubular membrane segments called cristae junctions (CJs). The formation and maintenance of CJs is of vital importance for the organization of the mitochondrial IM and for mitochondrial and cellular physiology. The multisubunit mitochondrial contact site and cristae organizing system (MICOS) was found to be a major factor in CJ formation...
March 2, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28252243/internally-2-5-thienylene-bridged-46-decaphyrin-annuleno-annulene-network-consisting-of-m%C3%A3-bius-aromatic-thia-28-hexaphyrins-and-strong-h%C3%A3-ckel-aromaticity-of-its-protonated-form
#7
Takanori Soya, Hirotaka Mori, Yongseok Hong, Yun Hee Koo, Dongho Kim, Atsuhiro Osuka
Internally 1,3-phenylene- and 2,5-thienylene-bridged [46]decaphyrins 2 and 3 have been synthesized. While 2 shows modest aromatic character derived from the global 46π-conjugated circuit, 3 displays larger aromatic character owing to the contribution of an (annuleno)annulene-type network consisting of two twisted Möbius aromatic thia[28]hexaphyrin segments in addition to the global 46π-network. Upon protonation, these [46]decaphyrins underwent large structural changes to acquire strong aromaticity. Protonated 3 has been revealed to take on a planar structure composed of fused two triangular thia[28]hexaphyrin segments...
March 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28248254/partial-immunoblotting-of-2d-gels-a-novel-method-to-identify-post-translationally-modified-proteins-exemplified-for-the-myelin-acetylome
#8
Kathrin Kusch, Marina Uecker, Thomas Liepold, Wiebke Möbius, Christian Hoffmann, Heinz Neumann, Hauke B Werner, Olaf Jahn
Post-translational modifications (PTMs) play a key role in regulating protein function, yet their identification is technically demanding. Here, we present a straightforward workflow to systematically identify post-translationally modified proteins based on two-dimensional gel electrophoresis. Upon colloidal Coomassie staining the proteins are partially transferred, and the investigated PTMs are immunodetected. This strategy allows tracking back the immunopositive antigens to the corresponding spots on the original gel, from which they are excised and mass spectrometrically identified...
January 12, 2017: Proteomes
https://www.readbyqxmd.com/read/28244634/m%C3%A3-bius-aromatic-28-hexaphyrin-germanium-iv-and-tin-iv-complexes-efficient-formation-of-triplet-exited-states
#9
Mondo Izawa, Taeyeon Kim, Shin-Ichiro Ishida, Takayuki Tanaka, Tadashi Mori, Dongho Kim, Atsuhiro Osuka
[28]Hexaphyrin Ge(IV) and Sn(IV) complexes were synthesized in high yields by reactions of [28]hexaphyrin with GeCl4 or SnCl4 in the presence of triethylamine. Both complexes display distinct 28π Möbius aromatic character and possess a trigonal bipyramidal geometry at the central Ge(IV) or Sn(IV) atom. The equatorial hydroxy group of the Ge(IV) complex was smoothly exchanged with neutral nucleophiles, such as phenol derivatives and thiophenol, with retention of configuration. In the Sn(IV) complex, intersystem crossing to the T1  state is remarkably enhanced owing to the effective heavy-atom effect, thus allowing the formation of the T1  state in high yield...
February 28, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28218996/hypoxia-stimulated-membrane-trafficking-requires-t-plastin
#10
Marieke Wottawa, Stephanie Naas, Johannes Böttger, Gijsbert J van Belle, Wiebke Möbius, Natalia H Revelo, Doris Heidenreich, Melanie von Ahlen, Anke Zieseniss, Katharina Kröhnert, Susanne Lutz, Christof Lenz, Henning Urlaub, Silvio O Rizzoli, Dörthe M Katschinski
Traffic between the plasma membrane and the endomembrane compartments is an essential feature of eukaryotic cells. The secretory pathway sends cargoes from biosynthetic compartments to the plasma membrane. This is counterbalanced by a retrograde endocytotic route and is essential for cell homeostasis. Cells need to adapt rapidly to environmental challenges like the reduction of pO2 which, however, has not been analyzed in relation to membrane trafficking in detail. Therefore we determined changes in the plasma membrane trafficking in normoxia, hypoxia, and after reoxygenation METHODS: Membrane trafficking was analyzed by using the bulk membrane endocytosis marker FM 1-43, the newly developed membrane probe mCLING, wheat germ agglutinin as well as fluorescently labeled choleratoxin subunit B...
February 20, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28165184/the-extension-of-baird-s-rule-to-twisted-heteroannulenes-aromaticity-reversal-of-singly-and-doubly-twisted-molecular-systems-in-the-lowest-triplet-state
#11
Yongseok Hong, Juwon Oh, Young Mo Sung, Yasuo Tanaka, Atsuhiro Osuka, Dongho Kim
We have investigated the aromaticity of singly twisted Möbius aromatic and doubly twisted Hückel antiaromatic bis(palladium(II)) [36]octaphyrins in the lowest triplet state (T1 ) by spectroscopic measurements and quantum calculations. The T1 state of the singly twisted Möbius [36]octaphyrin shows broad and weak absorption spectral features that are analogous to those of antiaromatic expanded porphyrins while the T1 state of the doubly twisted Hückel [36]octaphyrin exhibits intense and distinct spectral features, indicating the aromatic nature...
February 6, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28145065/positional-relations-of-the-cervical-vagus-nerve-revisited
#12
Uwe Planitzer, Niels Hammer, Ingo Bechmann, Juliane Glätzner, Sabine Löffler, Robert Möbius, Bernhard N Tillmann, David Weise, Dirk Winkler
OBJECTIVES: The cervical part of the vagus nerve (CVN) has become an important target for stimulation therapy to treat epilepsy and psychiatric conditions. For this purpose, the CVN is visualized in the carotid sheath, assuming it to be localized dorsomedially between the carotid artery (CA) and the internal jugular vein (JV). The aim of our morphological study was therefore to revisit the CVN relationships to the CA and JV, hypothesizing it to have common variations to this classical textbook anatomy...
February 1, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28144112/clinical-implementation-of-an-electron-monitor-unit-dosimetry-system-based-on-task-group-71-report-and-a-commercial-calculation-program
#13
Huijun Xu, Mariana Guerrero, Shifeng Chen, Xiaocheng Yang, Karl Prado, Colleen Schinkel
Many clinics still use monitor unit (MU) calculations for electron treatment planning and/or quality assurance (QA). This work (1) investigates the clinical implementation of a dosimetry system including a modified American Association of Physicists in Medicine-task group-71 (TG-71)-based electron MU calculation protocol (modified TG-71 electron [mTG-71E] and an independent commercial calculation program and (2) provides the practice recommendations for clinical usage. Following the recently published TG-71 guidance, an organized mTG-71E databook was developed to facilitate data access and subsequent MU computation according to our clinical need...
October 2016: Journal of Medical Physics
https://www.readbyqxmd.com/read/28117328/dietary-cholesterol-promotes-repair-of-demyelinated-lesions-in-the-adult-brain
#14
Stefan A Berghoff, Nina Gerndt, Jan Winchenbach, Sina K Stumpf, Leon Hosang, Francesca Odoardi, Torben Ruhwedel, Carolin Böhler, Benoit Barrette, Ruth Stassart, David Liebetanz, Payam Dibaj, Wiebke Möbius, Julia M Edgar, Gesine Saher
Multiple Sclerosis (MS) is an inflammatory demyelinating disorder in which remyelination failure contributes to persistent disability. Cholesterol is rate-limiting for myelin biogenesis in the developing CNS; however, whether cholesterol insufficiency contributes to remyelination failure in MS, is unclear. Here, we show the relationship between cholesterol, myelination and neurological parameters in mouse models of demyelination and remyelination. In the cuprizone model, acute disease reduces serum cholesterol levels that can be restored by dietary cholesterol...
January 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/28104946/mobious-syndrome-mr-findings
#15
Maskal Revanna Srinivas, Dhulappa Mudabasappagol Vaishali, Kadaba Shamachar Vedaraju, Bangalore Rangaswamy Nagaraj
Möbius syndrome is an extremely rare congenital disorder. We report a case of Möbius syndrome in a 2-year-old girl with bilateral convergent squint and left-sided facial weakness. The characteristic magnetic resonance imaging (MRI) findings of Möbius syndrome, which include absent bilateral abducens nerves and absent left facial nerve, were noted. In addition, there was absence of left anterior inferior cerebellar artery (AICA) and absence of bilateral facial colliculi. Clinical features, etiology, and imaging findings are discussed...
October 2016: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28076777/antagonistic-functions-of-mbp-and-cnp-establish-cytosolic-channels-in-cns-myelin
#16
Nicolas Snaidero, Caroline Velte, Matti Myllykoski, Arne Raasakka, Alexander Ignatev, Hauke B Werner, Michelle S Erwig, Wiebke Möbius, Petri Kursula, Klaus-Armin Nave, Mikael Simons
The myelin sheath is a multilamellar plasma membrane extension of highly specialized glial cells laid down in regularly spaced segments along axons. Recent studies indicate that myelin is metabolically active and capable of communicating with the underlying axon. To be functionally connected to the neuron, oligodendrocytes maintain non-compacted myelin as cytoplasmic nanochannels. Here, we used high-pressure freezing for electron microscopy to study these cytoplasmic regions within myelin close to their native state...
January 10, 2017: Cell Reports
https://www.readbyqxmd.com/read/28048620/su-f-t-308-mobius-fx-evaluation-and-comparison-against-a-commercial-4d-detector-array-for-vmat-plan-qa
#17
L Vazquez Quino, C Huerta Hernandez, A Morrow, B Massingill, D Rangaraj
PURPOSE: To evaluate the use of MobiusFX as a pre-treatment verification IMRT QA tool and compare it with a commercial 4D detector array for VMAT plan QA. METHODS: 15 VMAT plan QA of different treatment sites were delivered and measured by traditional means with the 4D detector array ArcCheck (Sun Nuclear corporation) and at the same time measurement in linac treatment logs (Varian Dynalogs files) were analyzed from the same delivery with MobiusFX software (Mobius Medical Systems)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048548/su-a-brc-02-the-path-of-a-chief-of-medical-physics
#18
D Shepard
This year's Annual Student Meeting consists of a panel of professionals who have pursued a traditional education in medical physics and have since pursued a variety of careers. These range from chief medical physicist, small business founder, FDA scientist, industry R&D scientist, and academic researcher. Each panelist will discuss their education, positions that they have held leading to their current one, and factors that influenced them to pursue their careers. Time will be left at the end of the talk to open the floor for questions from students and trainees...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048368/su-a-brc-05-the-path-of-a-fda-physicist
#19
R Ochs
This year's Annual Student Meeting consists of a panel of professionals who have pursued a traditional education in medical physics and have since pursued a variety of careers. These range from chief medical physicist, small business founder, FDA scientist, industry R&D scientist, and academic researcher. Each panelist will discuss their education, positions that they have held leading to their current one, and factors that influenced them to pursue their careers. Time will be left at the end of the talk to open the floor for questions from students and trainees...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047961/su-f-t-285-evaluation-of-a-patient-dvh-based-imrt-qa-system
#20
H Zhen, G Redler, J Chu, J Turian
PURPOSE: To evaluate the clinical performance of a patient DVH-based QA system for prostate VMAT QA. METHODS: Mobius3D(M3D) is a QA software with an independent beam model and dose engine. The MobiusFX(MFX) add-on predicts patient dose using treatment machine log files. We commissioned the Mobius beam model in two steps. First, the stock beam model was customized using machine commissioning data, then verified against the TPS with 12 simple phantom plans and 7 clinical 3D plans...
June 2016: Medical Physics
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