Sydney Levy, Ghaith Sharaf Dabbagh, John R Giudicessi, Haris Haqqani, Mohammed Y Khanji, Edmond Obeng-Gyimah, Megan N Betts, Fabrizio Ricci, Babken Asatryan, Nabila Bouatia-Naji, Saman Nazarian, C Anwar A Chahal
Mitral valve prolapse (MVP) is a heart valve disease that is often familial, affecting 2%-3% of the general population. MVP with or without mitral regurgitation can be associated with an increased risk of ventricular arrhythmias and sudden cardiac death (SCD). Research on familial MVP has specifically focused on genetic factors, which may explain the heritable component of the disease estimated to be present in 20%-35%. Furthermore, the structural and electrophysiological substrates underlying SCD/ventricular arrhythmia risk in MVP have been studied postmortem and in the electrophysiology laboratory, respectively...
September 2023: Heart rhythm O2