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mitral valve prolapse sudden death

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https://www.readbyqxmd.com/read/28424438/using-cardiovascular-imaging-modalities-to-determine-cardiac-disorders-before-starting-sports-activities
#1
Özgür Ceylan, Timur Meşe, Meşe Hazım Gürsu
OBJECTIVE: We re-examined children who had previously been declared eligible to participate in competitive sports activities for cardiac disorders, using cardiac investigation protocol. METHODS: Total of 250 children (224 males [89.6%], and 26 females [10.4%]) between the ages of 8 and 17 years who had just started or were already engaged in sports activities were included in the study. Participants had detailed physical examination evaluated by a pediatric cardiologist...
March 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28415082/p210long-term-outcome-of-primary-mitral-valve-prolapse-results-from-a-population-of-250-patients-referred-to-a-tertiary-cardiovascular-center
#2
V Mecarocci, F Mori
Background: Outcome of Mitral Valve Prolapse (MVP) was controversial for long time. Many studies reported great differences in the incidence of cardiovascular events due, above all, to heterogeneous and small studied populations. Most of theme were also published to late '80 of the last century till early '00. Purpose: To make a contemporary survey on the incidence of cardiovascular events in a selected population of patients affected by primary MVP referred to a tertiary cardiovascular center for the medical and surgical care of valvular heart disease...
December 1, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/27692657/detecting-underlying-cardiovascular-disease-in-young-competitive-athletes
#3
James McKinney, Daniel J Lithwick, Barbara N Morrison, Hamed Nazzari, Michael Luong, Christopher B Fordyce, Jack Taunton, Andrew D Krahn, Brett Heilbron, Saul Isserow
BACKGROUND: Sudden cardiac death (SCD) is frequently the first manifestation of underlying cardiovascular disease in young competitive athletes (YCAs), yet there are no Canadian guidelines for preparticipation screening in this population. The goal of this study was to determine the prevalence of potentially lethal cardiovascular disease in a sample of Canadian YCAs by comparing 2 screening strategies. METHODS: We prospectively screened 1419 YCAs in British Columbia, Canada (age 12-35 years)...
January 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/27516479/morphofunctional-abnormalities-of-mitral-annulus-and-arrhythmic-mitral-valve-prolapse
#4
Martina Perazzolo Marra, Cristina Basso, Manuel De Lazzari, Stefania Rizzo, Alberto Cipriani, Benedetta Giorgi, Carmelo Lacognata, Ilaria Rigato, Federico Migliore, Kalliopi Pilichou, Luisa Cacciavillani, Emanuele Bertaglia, Anna Chiara Frigo, Barbara Bauce, Domenico Corrado, Gaetano Thiene, Sabino Iliceto
BACKGROUND: Arrhythmic mitral valve prolapse (MVP) is characterized by myxomatous leaflets and left ventricular (LV) fibrosis of papillary muscles and inferobasal wall. We searched for morphofunctional abnormalities of the mitral valve that could explain a regional mechanical myocardial stretch. METHODS AND RESULTS: Thirty-six (27 female patients; median age: 44 years) arrhythmic MVP patients with LV late gadolinium enhancement on cardiac magnetic resonance and no or trivial mitral regurgitation, and 16 (6 female patients; median age: 40 years) MVP patients without LV late gadolinium enhancement were investigated by morphofunctional cardiac magnetic resonance...
August 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27413265/computed-tomography-coronary-angiography-diagnosis-of-single-right-coronary-artery-with-congenital-absence-of-left-coronary-artery-system-equivalents
#5
Shahyan Mohsin Siddiqui, R C Kesava Rao, Sashidhar Kaza, E A Padma Kumar
The present case report is computed tomography (CT) coronary angiographic depiction of an exceedingly rare entity-single right coronary artery arising from the right sinus of Valsalva with the absence of equivalent left coronary artery system branches and associated mitral valve prolapse. Even though a statistical rarity, it is potentially fatal and can cause myocardial ischemia, sudden cardiac death, and warrants immediate clinical attention. Further, the report reveals the decisive role of CT coronary angiogram in the diagnosis of such rare entities, in contrast to catheter angiography, which may be inconclusive...
April 2016: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/27251411/prolonged-tp-e-interval-and-tp-e-qt-ratio-in-children-with-mitral-valve-prolapse
#6
Mustafa Demirol, Cem Karadeniz, Rahmi Ozdemir, Şenay Çoban, Nagehan Katipoğlu, Yılmaz Yozgat, Timur Meşe, Nurettin Unal
Although it is considered to be a benign condition, previous studies have shown that a subset of patients with mitral valve prolapse (MVP) may be at risk of ventricular arrhythmia and sudden cardiac death (SCD). Previous studies have suggested that the interval between the peak and the end of the T wave (Tp-e) can be used as a marker for the transmural dispersion of repolarization. Increased Tp-e interval and Tp-e/QT ratio are associated with ventricular arrhythmias and SCD. The aim of this study was to assess alterations in ventricular repolarization by using the Tp-e interval and Tp-e/QT ratio in children with MVP and to investigate their relationships with the degree of valvular regurgitation...
August 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27249812/sudden-cardiac-arrest-and-coexisting-mitral-valve-prolapse-a-case-report-and-literature-review
#7
Mohamed Ahmed, Ashraf Roshdy, Rajan Sharma, Nick Fletcher
The aetiology of sudden cardiac arrest can often be identified to underlying cardiac pathology. Mitral valve prolapse is a relatively common valvular pathology with symptoms manifesting with increasing severity of mitral regurgitation (MR). It is unusual for severe MR to be present without symptoms, and there is growing evidence that this subset of patients may be at increased risk of sudden cardiac arrest or death. The difficulty lies in identifying those patients at risk and applying measures that are appropriate to halting progression to cardiac arrest...
March 2016: Echo Research and Practice
https://www.readbyqxmd.com/read/27231335/cardiovascular-diseases-in-paralympic-athletes
#8
Antonio Pelliccia, Filippo M Quattrini, Maria Rosaria Squeo, Stefano Caselli, Franco Culasso, Mark S Link, Antonio Spataro, Marco Bernardi
BACKGROUND: Sport participation (SP) of individuals with impairments has recently grown exponentially. Scarce scientific data, however, exist regarding cardiovascular (CV) risk associated with competitive SP. OBJECTIVE: Assessing the prevalence of CV abnormalities and the risk for SP in Paralympic athletes (PA). METHODS: PA (n=267; 76% men), aged 35±9 years, engaged in 18 sport disciplines, with a spectrum of lesions including: spinal cord injury (paraplegia and spina bifida) (n=116); amputation, poliomyelitis, cerebral palsy and other neuromuscular and/or skeletal disorders (Les autres) or visual impairment (n=151) entered the study...
September 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27138925/gender-and-cardiovascular-mortality-in-northern-and-southern-european-populations
#9
REVIEW
Paolo Emilio Puddu, Michele Schiariti, Concetta Torromeo
BACKGROUND: There are no ready explanations for differences in ischemic heart disease incidence between women and men under an epidemiological perspective. However, when myocardial infarction occurs, there are more likely individuals who happen to die. METHODS: This review from a more recent literature was performed for a two-fold purpose, to describe gender wise: a) the role of classical and novel factors defined to evaluate coronary artery disease (CAD) risk and mortality, aimed at assessing applicability and relevance for primary and secondary prevention; b) the differences in northern versus southern European Countries in risk factors and CAD mortality...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/26846766/post-mortem-whole-exome-sequencing-wes-with-a-focus-on-cardiac-disease-associated-genes-in-five-young-sudden-unexplained-death-sud-cases
#10
Jacqueline Neubauer, Cordula Haas, Christine Bartsch, Argelia Medeiros-Domingo, Wolfgang Berger
Sudden death of healthy young adults in the absence of any medical reason is generally categorised as autopsy-negative sudden unexplained death (SUD). Approximately 30 % of all SUD cases can be explained by lethal sequence variants in cardiac genes causing disturbed ion channel functions (channelopathies) or minimal structural heart abnormalities (cardiomyopathies). The aim of this study was to perform whole-exome sequencing (WES) in five young SUD cases in order to identify potentially disease-causing mutations with a focus on 184 genes associated with cardiac diseases or sudden death...
July 2016: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/26416619/mitral-valve-prolapse-and-sudden-cardiac-arrest-in-the-community
#11
Kumar Narayanan, Audrey Uy-Evanado, Carmen Teodorescu, Kyndaron Reinier, Gregory A Nichols, Karen Gunson, Jonathan Jui, Sumeet S Chugh
BACKGROUND: Mitral valve prolapse (MVP) is relatively common in the general population with recently reported prevalence of 1% and familial clustering (Framingham Heart Study). However, its association with ventricular arrhythmias and sudden cardiac arrest (SCA) remains controversial. OBJECTIVES: The purpose of this study was to characterize the frequency and clinical profile of patients with MVP who suffer SCA in the community. METHODS: Patients with SCA cases were prospectively identified in the population-based Oregon Sudden Unexpected Death Study (population ~1 million)...
February 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/26301497/genetic-association-analyses-highlight-biological-pathways-underlying-mitral-valve-prolapse
#12
Christian Dina, Nabila Bouatia-Naji, Nathan Tucker, Francesca N Delling, Katelynn Toomer, Ronen Durst, Maelle Perrocheau, Leticia Fernandez-Friera, Jorge Solis, Thierry Le Tourneau, Ming-Huei Chen, Vincent Probst, Yohan Bosse, Philippe Pibarot, Diana Zelenika, Mark Lathrop, Serge Hercberg, Ronan Roussel, Emelia J Benjamin, Fabrice Bonnet, Su Hao Lo, Elena Dolmatova, Floriane Simonet, Simon Lecointe, Florence Kyndt, Richard Redon, Hervé Le Marec, Philippe Froguel, Patrick T Ellinor, Ramachandran S Vasan, Patrick Bruneval, Roger R Markwald, Russell A Norris, David J Milan, Susan A Slaugenhaupt, Robert A Levine, Jean-Jacques Schott, Albert A Hagege, Xavier Jeunemaitre
Nonsyndromic mitral valve prolapse (MVP) is a common degenerative cardiac valvulopathy of unknown etiology that predisposes to mitral regurgitation, heart failure and sudden death. Previous family and pathophysiological studies suggest a complex pattern of inheritance. We performed a meta-analysis of 2 genome-wide association studies in 1,412 MVP cases and 2,439 controls. We identified 6 loci, which we replicated in 1,422 cases and 6,779 controls, and provide functional evidence for candidate genes. We highlight LMCD1 (LIM and cysteine-rich domains 1), which encodes a transcription factor and for which morpholino knockdown of the ortholog in zebrafish resulted in atrioventricular valve regurgitation...
October 2015: Nature Genetics
https://www.readbyqxmd.com/read/26160860/the-knot-that-binds-mitral-valve-prolapse-and-sudden-cardiac-death
#13
EDITORIAL
Peter A Noseworthy, Samuel J Asirvatham
No abstract text is available yet for this article.
August 18, 2015: Circulation
https://www.readbyqxmd.com/read/26160859/arrhythmic-mitral-valve-prolapse-and-sudden-cardiac-death
#14
Cristina Basso, Martina Perazzolo Marra, Stefania Rizzo, Manuel De Lazzari, Benedetta Giorgi, Alberto Cipriani, Anna Chiara Frigo, Ilaria Rigato, Federico Migliore, Kalliopi Pilichou, Emanuele Bertaglia, Luisa Cacciavillani, Barbara Bauce, Domenico Corrado, Gaetano Thiene, Sabino Iliceto
BACKGROUND: Mitral valve prolapse (MVP) may present with ventricular arrhythmias and sudden cardiac death (SCD) even in the absence of hemodynamic impairment. The structural basis of ventricular electric instability remains elusive. METHODS AND RESULTS: The cardiac pathology registry of 650 young adults (≤40 years of age) with SCD was reviewed, and cases with MVP as the only cause of SCD were re-examined. Forty-three patients with MVP (26 females; age range, 19-40 years; median, 32 years) were identified (7% of all SCD, 13% of women)...
August 18, 2015: Circulation
https://www.readbyqxmd.com/read/26119456/a-case-of-sudden-cardiac-death-following-domperidone-self-medication
#15
Paolo Fais, Elisa Vermiglio, Chiara Laposata, Robert Lockwood, Rossella Gottardo, Domenico De Leo
The phenomenon of sudden cardiac death is usually related to the worsening of existing heart conditions leading to ventricular arrhythmia (VA). One of the well-known triggers of SCD is drug-induced prolongation of the QT interval, such as that caused by Domperidone (D). Despite its risk to prolong the QT interval and associated narrow therapeutic index, D is available as an over-the-counter (OTC) drug in many countries such as Italy, Ireland, Netherlands, China, South Africa, Mexico, New Zealand and Chile to treat gastroesophageal reflux and functional dyspepsia...
September 2015: Forensic Science International
https://www.readbyqxmd.com/read/26071830/sudden-cardiac-death-mitral-valve-prolapse-and-long-qt-syndrome
#16
LETTER
Emil Missov, Rebecca Cogswell
No abstract text is available yet for this article.
October 2015: American Journal of Medicine
https://www.readbyqxmd.com/read/25987923/emergent-presentation-of-decompensated-mitral-valve-prolapse-and-atrial-septal-defect
#17
Jessie Kang, Bijon Das
Mitral valve prolapse is not commonly on the list of differential diagnosis when a patient presents in the emergency department (ED) in severe distress, presenting with non-specific features such as abdominal pain, tachycardia and dyspnea. A healthy 55-year-old man without significant past medical history arrived in the ED with a unique presentation of a primary mitral valve prolapse with an atrial septal defect uncommon in cardiology literature. Early recognition of mitral valve prolapse in high-risk patients for severe mitral regurgitation or patients with underlying cardiovascular abnormalities such as an atrial septal defect is crucial to prevent morbid outcomes such as sudden cardiac death...
May 2015: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/25885138/idiopathic-mitral-valve-prolapse-with-tricuspid-aortic-and-pulmonary-valve-involvement-an-autopsy-case-report
#18
Heena M Desai, Gayathri P Amonkar
Mitral valve prolapse (MVP) is usually asymptomatic, but can be associated with complications such as infective endocarditis, mitral regurgitation, thromboembolism and sudden cardiac death. It has been very rarely reported to occur in association with other valvular involvement. A 55-year-old male patient was brought dead and at autopsy the mitral valve orifice was stenotic and the leaflets were enlarged, myxoid and bulging suggestive of MVP and chordae tendinae were thickened, stretched and elongated. Similar changes were seen in the tricuspid valve...
April 2015: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/25870356/left-coronary-artery-stenosis-causing-left-ventricular-dysfunction-in-two-children-with-supravalvular-aortic-stenosis
#19
Okan Yildiz, Firat H Altin, Mehmet Kaya, Isa Ozyılmaz, Alper Guzeltas, Ersin Erek
Congenital supravalvar aortic stenosis (SVAS) is an arteriopathy associated with Williams-Beuren syndrome (WBS) and other isolated elastin gene deletions. Cardiovascular manifestations associated with WBS are characterized by obstructive arterial lesions such as SVAS and pulmonary artery stenosis in addition to bicuspid aortic valve and mitral valve prolapse. However, coronary artery ostial stenosis may be associated with SVAS, and it increases the risk of sudden death and may complicate surgical management...
April 2015: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/25851088/myxomatous-mitral-valve-disease-and-related-entities-the-role-of-matrix-in-valvular-heart-disease
#20
W M Lester
Myxomatous mitral valve disease is a cause of prolapse of mitral valve leaflet(s) into the left atrium. In this condition there is a loss of collagen from the leaflet and an accumulation of glycosaminoglycan. Complications of myxomatous mitral valve disease include infective endocarditis, mitral regurgitation, sudden death, and stroke. Mitral valve prolapse has been reported to occur in association with many syndromes. In some of these, such as Marfan syndrome, the pathology of the mitral valve has been well described and is that of a myxomatous valve...
October 1995: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
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