Deborah A Jehu, Yanbin Dong, Haidong Zhu, Ying Huang, Andre Soares, Charmi Patel, Zak Aden, Colleen Hergott, Brittany Ange, Jennifer L Waller, Lufei Young, William Hall, Dawnchelle Robinson-Johnson, Crystal Allen, Richard Sams, Mark Hamrick
BACKGROUND: Exercise may improve executive function among people living with all-cause dementia (PWD), but more evidence is needed. The aim of this pilot randomized controlled trial (RCT) is to examine whether exercise plus usual care improves the primary outcome of executive function, and secondary physiological (inflammation, metabolic aging, epigenetics) and behavioral (cognition, psychological health, physical function, and falls) outcomes compared to usual care alone among PWD. METHODS AND STUDY DESIGN: The strEngth aNd BaLance exercise on Executive function in people living with Dementia (ENABLED) protocol is a pilot parallel, 6-month assessor-blinded RCT (1:1) in residential care facilities, including n = 21 receiving exercise plus usual care and n = 21 usual care alone [NCT05488951]...
May 6, 2023: Contemporary Clinical Trials