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L Spain, G Walls, M Julve, K O'Meara, T Schmid, E Kalaitzaki, S Turajlic, M Gore, J Rees, J Larkin
Background: Treatment with immune checkpoint inhibitors (ICPi) has greatly improved survival for patients with advanced melanoma in recent years. Anti-CTLA-4 and anti-PD1 antibodies have been approved following large Phase III trials. Immune-related neurological toxicity of varying severity has been reported in the literature. The cumulative incidence of neurotoxicity among ipilimumab, nivolumab and pembrolizumab is reported as <1% in published clinical trials. We aimed to identify the incidence of neurotoxicity in our institution across anti-CTLA4 and anti-PD-1 antibodies, including the combination of ipilimumab with nivolumab...
February 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Salvatore Caponnetto, Giovanni Maria Iannantuono, Giacomo Barchiesi, Valentina Magri, Alain Gelibter, Enrico Cortesi
BACKGROUND/AIMS: Prolactin (PRL) is a peptide hormone and several studies have demonstrated its role as a cytokine in human T cell-mediated immunity. We are unaware if PRL is a positive or negative immunomodulator, but its effects on the regulation of T cells could inhibit the antitumor activity elicited by nivolumab (NIVO). We aimed to assess whether the occurrence of hyperprolactinemia in metastatic non-small cell lung cancer (mNSCLC) patients treated with NIVO is associated with poor clinical outcomes...
April 14, 2017: Oncology
Christine G Kohn, Simon B Zeichner, Qiushi Chen, Alberto J Montero, Daniel A Goldstein, Christopher R Flowers
Purpose Patients who are diagnosed with stage IV metastatic melanoma have an estimated 5-year relative survival rate of only 17%. Randomized controlled trials of recent US Food and Drug Administration-approved immune checkpoint inhibitors-pembrolizumab (PEM), nivolumab (NIVO), and ipilumumab (IPI)-demonstrate improved patient outcomes, but the optimal treatment sequence in patients with BRAF wild-type metastatic melanoma remains unclear. To inform policy makers about the value of these treatments, we developed a Markov model to compare the cost-effectiveness of different strategies for sequencing novel agents for the treatment of advanced melanoma...
April 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Rahul Ladwa, Victoria Atkinson
The optimal duration of PD-1 antibodies for metastatic melanoma is unknown. In previous trials, there has been the potential to cease therapy if the patient achieves a complete response (CR). We aimed to assess the outcomes of patients who had ceased anti-PD-1 antibodies in this setting. A retrospective review was carried out of CR to PD-1-based therapy across two institutions. Patients were from the Pembrolizumab Named Patient Program (PEM NPP), Nivolumab monotherapy (NIVO), and reimbursed Pembrolizumab (r PEM)...
January 17, 2017: Melanoma Research
Jonathan W Goldman, Lucio Crino, Everett E Vokes, Esther Holgado, Karen Reckamp, Adam Pluzanski, David Spigel, Martin Kohlhaeufl, Marina Garassino, Laura Qm Chow, Scott Gettinger, David E Gerber, Libor Havel, Suresh S Ramalingam, Grace K Dy, William J Geese, Ang Li, Anne Blackwood-Chirchir, Diane Healey, Julie Brahmer, Gilberto Lopes
No abstract text is available yet for this article.
October 2016: Journal of Thoracic Oncology
Melanie Sauerland, Linsey H C Raymaekers, Henry Otgaar, Amina Memon, Thijs T Waltjen, Maud Nivo, Chiel Slegers, Nick J Broers, Tom Smeets
In the eyewitness identification literature, stress and arousal at the time of encoding are considered to adversely influence identification performance. This assumption is in contrast with findings from the neurobiology field of learning and memory, showing that stress and stress hormones are critically involved in forming enduring memories. This discrepancy may be related to methodological differences between the two fields of research, such as the tendency for immediate testing or the use of very short (1-2 hours) retention intervals in eyewitness research, while neurobiology studies insert at least 24 hours...
July 2016: Behavioral Sciences & the Law
E Felip, J Van Meerbeeck, J Wolf, A Ardizzoni, A Li, S Srinivasan, S Popat
No abstract text is available yet for this article.
April 2016: Journal of Thoracic Oncology
Kyung A Lee, Krishna M Palipudi, Lorna M English, Nivo Ramanandraibe, Samira Asma
BACKGROUND: Exposure to secondhand smoke (SHS) causes premature death and illness in non-smokers. We examined SHS exposure at home and in public places, as well as susceptibility to initiate cigarette smoking among never cigarette smokers. We used 2006-2011 Global Youth Tobacco Survey (GYTS) data from 29 African countries (56,967 students). METHODS: GYTS is a nationally representative, self-administered school-based survey, conducted among students aged 13-15years...
October 2016: Preventive Medicine
Lazarous Mbulo, Nwokocha Ogbonna, Isiaka Olarewaju, Emmanuel Musa, Simone Salandy, Nivo Ramanandraibe, Krishna Palipudi
INTRODUCTION: Tobacco is a major preventable cause of disease and death globally and increasingly shifting its burden to low and middle-income countries (LMICs) including African countries. We use Nigeria Global Adult Tobacco Survey data to examine indications of a potential tobacco epidemic in a LMIC setting and provide potential interventions to prevent the epidemic. METHODOLOGY: Global Adult Tobacco Survey data from Nigeria (2012; sample=9765) were analyzed to examine key tobacco indicators...
October 2016: Preventive Medicine
Muhammad Jami Husain, Lorna McLeod English, Nivo Ramanandraibe
Tobacco smoking prevalence remains low in many African countries. However, growing economies and the increased presence of multinational tobacco companies in the African Region have the potential to contribute to increasing tobacco use rates in the future. This paper used data from the 2014 Global Progress Report on implementation of the World Health Organization Framework Convention on Tobacco Control (WHO FCTC), as well as the 2015 WHO report on the global tobacco epidemic, to describe the status of tobacco control and prevention efforts in countries in the WHO African Region relative to the provisions of the WHO FCTC and MPOWER package...
October 2016: Preventive Medicine
Lazarous Mbulo, Krishna Mohan Palipudi, Linda Andes, Jeremy Morton, Rizwan Bashir, Heba Fouad, Nivo Ramanandraibe, Roberta Caixeta, Rula Cavaco Dias, Trudy M A Wijnhoven, Mina Kashiwabara, Dhirendra N Sinha, Edouard Tursan d'Espaignet
OBJECTIVE: Children are vulnerable to secondhand smoke (SHS) exposure because of limited control over their indoor environment. Homes remain the major place where children may be exposed to SHS. Our study examines the magnitude, patterns and determinants of SHS exposure in the home among children in 21 countries (19 low-income and middle-income countries and 2 high-income countries). METHODS: Global Adult Tobacco Survey (GATS) data, a household survey of people 15 years of age or older...
December 2016: Tobacco Control
Rachna Chandora, Yang Song, Martine Chaussard, Krishna Mohan Palipudi, Kyung Ah Lee, Nivo Ramanandraibe, Samira Asma
OBJECTIVE: Tobacco smoking is initiated and established mostly during adolescence. The World Health Organization (WHO) Framework Convention on Tobacco Control (FCTC) Article 16 outlines the obligation of parties to prohibit the sale of tobacco products to minors. This study examined where and how student smokers obtain cigarettes. METHODS: We examined Global Youth Tobacco Survey (GYTS) data from 2009 to 2011 on cigarette access among students aged 13-15 in six sub-Saharan African countries...
October 2016: Preventive Medicine
Tasuku Sano, Hisashi Uhara, Yasutomo Mikoshiba, Aya Kobayashi, Ryuhei Uchiyama, Kazunari Tateishi, Hiroshi Yamamoto, Ryuhei Okuyama
We report the case of a 70-year-old woman with vaginal melanoma and multiple metastases in the lung. After the third dose of nivolumab, decreased room-air resting arterial oxygen saturation with bilateral basal fine crackles on auscultation developed despite the absence of respiratory symptoms. Computed tomography showed ground-glass opacities with airspace consolidations scattered with a peculiar distribution, and most were observed around the existing metastatic tumors in the lung. From the 42nd day to the 56th day after the last administration of nivolumab, she received dexamethasone 1-2 mg/body for the prevention of adverse events after stereotactic radiation for brain metastasis...
March 2016: Japanese Journal of Clinical Oncology
Nivo H Rakotoarivelo, Fortunat Rakotoarivony, Aro Vonjy Ramarosandratana, Vololoniaina H Jeannoda, Alyse R Kuhlman, Armand Randrianasolo, Rainer W Bussmann
BACKGROUND: Traditional medicine remains the only health care available in many rural areas in Madagascar like the rural community of Ambalabe, located in a very remote area in the eastern part of the country. With limited access to modern medicine, the local population uses medicinal plants to treat most diseases. In this study, we aimed to inventory medicinal plants used by local people and how those relate to the treatment of the most frequent diseases encountered in Ambalabe. METHODS: We interviewed participants in order to identify the most frequent diseases in the region and the medicinal plants used to treat them...
2015: Journal of Ethnobiology and Ethnomedicine
Maria Nirina Randriamiharisoa, Alyse R Kuhlman, Vololoniaina Jeannoda, Harison Rabarison, Nivo Rakotoarivelo, Tabita Randrianarivony, Fortunat Raktoarivony, Armand Randrianasolo, Rainer W Bussmann
BACKGROUND: This study focuses on the large outdoor markets of the capital of Madagascar, Antananarivo. As the largest metropolitan area in Madagascar with a population of nearly two million, the region has great capacity for consumption of medicinal plant remedies despite numerous pharmacies. Medicinal plant use spans all socioeconomic levels, and the diverse metropolitan population allows us to study a wide variety of people who consume these plants for medical purposes. The purpose of this study is to identify and generate a list of medicinal plants sold in the traditional markets with a focus on those collected in the forests around Antananarivo, get an idea of the quantities of medicinal plants sold in the markets around Antananarivo, and assess the economy of the medicinal plant markets...
2015: Journal of Ethnobiology and Ethnomedicine
Nivo Rakotoarivelo, Aina Razanatsima, Fortunat Rakotoarivony, Lucien Rasoaviety, Aro Vonjy Ramarosandratana, Vololoniaina Jeannoda, Alyse R Kuhlman, Armand Randrianasolo, Rainer W Bussmann
BACKGROUND: Known worldwide as the "traveler's tree", the Malagasy endemic species Ravenala madagascariensis Sonn. (Strelitziaceae) is considered as an iconic symbol of Madagascar. It is a widespread species in the eastern part of the country with four different varieties which are well represented in Ambalabe community. All of them are used for different purposes and the species represents an important cultural value in the lives of the local population. However, uses of Ravenala are only generally well known by local population...
2014: Journal of Ethnobiology and Ethnomedicine
Jean-Bernard Michotte, Emilie Jossen, Jean Roeseler, Giuseppe Liistro, Grégory Reychler
BACKGROUND: Few studies on performance comparison of nebulizer systems coupled with a single-limb circuit bilevel ventilator are available. Most of these data compared the aerosol drug delivery for only two different systems. Using an adult lung bench model of noninvasive ventilation, we compared inhaled and lost doses of three nebulizer systems coupled with a single-limb circuit bilevel ventilator, as well as the influence of the nebulizer position. METHOD: Three vibrating mesh nebulizers (Aeroneb(®) Pro, Aeroneb(®) Solo, and NIVO(®)), one jet nebulizer (Sidestream(®)), and one ultrasonic nebulizer (Servo Ultra Nebulizer 145(®)) coupled with a bilevel ventilator were tested...
December 2014: Journal of Aerosol Medicine and Pulmonary Drug Delivery
Mendrika Razafindraibe, Alyse R Kuhlman, Harison Rabarison, Vonjison Rakotoarimanana, Charlotte Rajeriarison, Nivo Rakotoarivelo, Tabita Randrianarivony, Fortunat Rakotoarivony, Reza Ludovic, Armand Randrianasolo, Rainer W Bussmann
BACKGROUND: The country of Madagascar is renowned for its high level of biodiversity and endemism, as well as the overwhelming pressures and threats placed on the natural resources by a growing population and climate change. Traditional medicine plays an important role in the daily lives of the Malagasy for various reasons including limited access to healthcare, limited markets and traditional values. The objective of this study was to assess the modern utitilization of the Agnalazaha Forest by the local population in Mahabo-Mananivo, Madagascar, for medicinal plants used by women, and to establish a list of medicinal plants used by women sourced from Agnalazaha Forest...
2013: Journal of Ethnobiology and Ethnomedicine
Krishna Mohan Palipudi, Jeremy Morton, Jason Hsia, Linda Andes, Samira Asma, Brandon Talley, Roberta D Caixeta, Heba Fouad, Rula N Khoury, Nivo Ramanandraibe, James Rarick, Dhirendra N Sinha, Sameer Pujari, Edouard Tursan d'Espaignet
In 2008, the Centers for Disease Control and Prevention (CDC) and the World Health Organization developed the Global Adult Tobacco Survey (GATS), an instrument to monitor global tobacco use and measure indicators of tobacco control. GATS, a nationally representative household survey of persons aged 15 years or older, was conducted for the first time during 2008-2010 in 14 low- and middle-income countries. In each country, GATS used a standard core questionnaire, sample design, and procedures for data collection and management and, as needed, added country-specific questions that were reviewed and approved by international experts...
June 2016: Global Health Promotion
Yang Song, Luhua Zhao, Krishna Mohan Palipudi, Samira Asma, Jeremy Morton, Brandon Talley, Jason Hsia, Nivo Ramanandraibe, Roberta Caixeta, Heba Fouad, Rula Khoury, Dhirendra Sinha, James Rarick, Douglas Bettcher, Armando Peruga, Katherine Deland, Edouard Tursan D'Espaignet
BACKGROUND: The World Health Organization (WHO) MPOWER is a technical package of six tobacco control measures that assist countries in meeting their obligations of the WHO Framework Convention Tobacco Control and are proven to reduce tobacco use. The Global Adult Tobacco Survey (GATS) systematically monitors adult tobacco use and tracks key tobacco control indicators. METHODS: GATS is a nationally representative household survey of adults aged 15 and older, using a standard and consistent protocol across countries; it includes information on the six WHO MPOWER measures...
June 2016: Global Health Promotion
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