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cervical cancer radiation

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https://www.readbyqxmd.com/read/29348871/radiation-therapy-for-stage-iva-uterine-cervical-cancer-treatment-outcomes-including-prognostic-factors-and-risk-of-vesicovaginal-and-rectovaginal-fistulas
#1
Masaharu Hata, Izumi Koike, Etsuko Miyagi, Reiko Numazaki, Mikiko Asai-Sato, Hisashi Kaizu, Yuki Mukai, Shoko Takano, Eiko Ito, Madoka Sugiura, Tomio Inoue
Purpose: To evaluate the safety and efficacy of radiation therapy for stage IVA uterine cervical cancer and to identify an optimal radiation regimen. Results: Seventeen of the 28 patients developed recurrence after radiation therapy (local recurrence in 10 and distant metastasis in 12). The local control and distant metastasis-free rates at 3 years in all patients were 61% and 49%, respectively. Fourteen patients died after radiation therapy, and all but 2 died of tumor progression...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29339540/radio-resistant-cervical-cancers-are-sensitive-to-inhibition-of-glycolysis-and-redox-metabolism
#2
Ramachandran Rashmi, Xiaojing Huang, John M Floberg, Adnan Elhammali, Michael L McCormick, Gary J Patti, Douglas R Spitz, Julie K Schwarz
Highly glycolytic cervical cancers largely resist treatment by cisplatin and co-administered pelvic irradiation as the present standard of care. In this study, we investigated the effects of inhibiting glycolysis and thiol redox metabolism to evaluate them as alternate treatment strategies in these cancers. In a panel of multiple cervical cancer cell lines, we evaluated sensitivity to inhibition of glycolysis (2-DG) with or without simultaneous inhibition of glutathione and thioredoxin metabolism (BSO/AUR)...
January 16, 2018: Cancer Research
https://www.readbyqxmd.com/read/29336760/cancer-frequency-in-retrosternal-goiter
#3
Nuri A Sahbaz, Firat Tutal, Nihat Aksakal, Sami Acar, Kadir I Aksu, Umut Barbaros, Yesim Erbil
Retrosternal goiter prevalence is 5 to 40 per cent according to classifications in goiter series. Goiters with mediastinal extension were reported to be related with higher cancer rates. In our study, we aimed to investigate whether cancer incidence increased in retrosternal goiters compared with the cervical ones. Three hundred and ninety consecutive patients, who had surgery because of retrosternal goiter in Istanbul University Medical Faculty Department of General Surgery between 2005 and 2015 were included in the study (Group 1)...
December 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29326769/osteoradionecrosis-in-subaxial-cervical-spine-a-rare-and-devastating-complication-a-case-report
#4
M Z Rashid, M H Ariffin, S A Rhani, A Baharudin, K Ibrahim
Osteoradionecrosis, a rare complication of radiation therapy, is a slow progression disease which affects the surrounding structures of spinal components. It essentially weakens the soft tissue and bony configuration and can cause nerve impingement or cord compression. We describe a patient who underwent radiotherapy for thyroid cancer and presented with cervical kyphosis with anterolisthesis of C3/C4 and C4/C5 some 32 years later. We explore the role of anterior and posterior fusion, as well as hyperbaric oxygen therapy in promoting healing...
November 2017: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/29324547/stereotactic-body-radiation-therapy-intensity-modulated-radiation-therapy-and-brachytherapy-boost-modalities-in-invasive-cervical-cancer-a-study-of-the-national-cancer-data-base
#5
Barrett OʼDonnell, Jay C Shiao, Todd A Pezzi, Nabila Waheed, Shelly Sharma, Mark D Bonnen, Michelle S Ludwig
BACKGROUND AND PURPOSE: Our objective was to determine whether stereotactic body radiotherapy (SBRT), intensity-modulated radiation therapy (IMRT), and brachytherapy boost techniques have comparable overall survival in treating cervical cancer when adjusted for known prognostic factors. MATERIALS AND METHODS: We used the National Cancer Database to study women with invasive cervical cancer who were treated with radiation between 2004 and 2013. A logistic regression model was built to identify factors associated with the receipt of SBRT and IMRT...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29324535/evaluating-the-role-of-f-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-scanning-in-the-staging-of-patients-with-stage-iiib-cervical-carcinoma-and-the-impact-on-treatment-decisions
#6
Marguerite Morkel, Annare Ellmann, James Warwick, Hannah Simonds
OBJECTIVE: FIGO (International Federation of Gynaecology and Obstetrics) staging is currently the most widely used clinical staging system for cervical cancer; however, this staging system has many shortcomings. One of these shortcomings is that lymph nodal status, specifically the para-aortic lymph nodal status, does not get taken into account. It is known that metabolic changes occur before changes are seen on anatomical imaging, and it is therefore possible to detect metastases earlier with the help of fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT)...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29319649/decreasing-radiation-exposure-in-pediatric-trauma-related-to-cervical-spine-clearance-a-quality-improvement-project
#7
Valerie Ann Waddell, Susan Connelly
STUDY DESIGN: Quality improvement project. OBJECTIVES: Reduce the amount of radiation exposure in the pediatric trauma population 5 years of age and older in relation to cervical spine clearance. BACKGROUND: The evaluation of pediatric cervical spine injuries must be accurate and timely to avoid missed injuries. The difficult clinical examination in pediatric trauma patients necessitates the use of radiologic examinations to avoid missing catastrophic injuries...
January 2018: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
https://www.readbyqxmd.com/read/29318915/the-overexpression-of-pxn-promotes-tumor-progression-and-leads-to-radioresistance-in-cervical-cancer
#8
Qiuli Liu, Jing Wang, Mei Tang, Ling Chen, Xiaowei Qi, Juan Li, Jinjin Yu, Haifeng Qiu, Yuan Wang
AIM: We aim to investigate the functions of PXN in cervical cancer. MATERIALS & METHODS: PXN protein was investigated by immunohistochemistry in a panel of cervical cancer. A series of in vitro and in vivo assays were used to explore the efficacy of PXN. RESULTS: PXN was significantly upregulated in cervical cancer, which associated with tumor stage, poor differentiation, lymphovascular space invasion and lymphatic metastasis. Knockdown of PXN notably impaired cellular growth and colony formation by suppressing Bcl-2 and inducing marked apoptosis...
January 10, 2018: Future Oncology
https://www.readbyqxmd.com/read/29313165/effectiveness-of-sacral-nerve-stimulation-in-fecal-incontinence-after-multimodal-oncologic-treatment-for-pelvic-malignancies-a-multicenter-study-with-2-year-follow-up
#9
M Schiano di Visconte, G A Santoro, N Cracco, G Sarzo, G Bellio, M Brunner, Z Cui, K E Matzel
BACKGROUND: To assess whether sacral nerve stimulation (SNS) is an effective treatment for severe fecal incontinence (FI) after radiotherapy (RT)/chemoRT (CRT) in combination with pelvic surgery. METHODS: A multicenter study was conducted on patients with FI that developed after multimodal therapy for pelvic tumors and was refractory to non-operative management, who were treated with SNS between November 2009 and November 2012. Data were prospectively collected and retrospectively analyzed...
January 8, 2018: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29280456/magnetic-resonance-image-guided-adaptive-brachytherapy-in-locally-advanced-cervical-cancer-an-experience-from-a-tertiary-cancer-center-in-a-low-and-middle-income-countries-setting
#10
Umesh Mahantshetty, Rahul Krishnatry, Vinod Hande, Swamidas Jamema, Yogesh Ghadi, Reena Engineer, Supriya Chopra, Lavanya Gurram, Deepak Deshpande, Shyamkishore Shrviastava
PURPOSE: To determine the clinical impact of magnetic resonance image guided adaptive brachytherapy (IGABT) for locally advanced cervical cancer (LACC) (stages II and III) in a tertiary care cancer hospital in a low and middle income countries setting. METHODS AND MATERIALS: Ninety-four LACC patients enrolled in a prospective EMBRACE (An International Study on MRI-Guided Brachytherapy in Locally Advanced Cervical Cancer) protocol treated with external radiation therapy (45 Gy in 25 fractions) with or without weekly cisplatin, followed by magnetic resonance IGABT (4 fractions of 7 Gy), were analyzed in detail for dosimetric and clinical outcomes including late toxicities...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29279868/uretero-arterio-enteric-fistula-formation-and-stent-thrombosis-after-endovascular-treatment-of-ureteroarterial-fistula-a-case-report-and-review-of-literature
#11
Hailiu Yang, Ricardo Rios, Joseph Lombardi, Dean Matthew Marella, Allen D Seftel
Background: Ureteroarterial fistulas (UAFs) are rare life-threatening complications of indwelling ureteral stents. Endovascular repair of these fistulas is now commonly used but the long-term outcomes are unknown. Case Presentation: We present a 51-year-old African American female with history of cervical cancer status after a hysterectomy and radiation. She has bilateral ureteral strictures that were managed with chronic, indwelling ureteral stents. She subsequently developed a right UAF and was treated with an endovascular stent to the external iliac artery...
2017: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/29275237/management-of-radiation-induced-bilateral-primary-tha-loosening-with-an-aseptic-paprosky-type-iib-acetabular-defect-and-a-contralateral-septic-type-iiib-acetabular-defect-a-case-report-and-review-of-literature
#12
Mohit M Kukreja, Steven K Nishiyama, Parminder S Kang
INTRODUCTION: Primary THA in an irradiated hip poses risk for early loosening and inadequate ingrowth.Adverse effects such as decreased vascularity and increased infection risk pose a threat. CASE PRESENTATION: Our patient was a case of post-irradiation (for cervical cancer) bilateral THA loosening causing aseptic acetabular loosening on one side and catastrophic septic loosening with a Paprosky type IIIB acetabular defect with pelvic discontinuity on the contralateral side...
December 9, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29273076/highly-conformal-combined-radiotherapy-with-cisplatin-and-gemcitabine-for-treatment-of-loco-regionally-advanced-cervical-cancer-a-retrospective-study
#13
Nikola Cihoric, Alexandros Tsikkinis, Eugenia Vlaskou Badra, Markus Glatzer, Urban Novak, Amina Scherz, Mohamed Shelan, Ivan Soldatovic, Chittazhathu Kurian Kuruvilla Yojena, Daniel M Aebersold, Kristina Lössl
BACKGROUND: Cisplatin and gemcitabine combined with conventional radiation therapy in the treatment of cervical cancer patients results in a favorable outcome but with excess toxicity. The purpose of this study was to evaluate the toxicity profile of dual chemotherapy and highly conformal external beam radiotherapy with image guided adaptive brachytherapy. METHODS: Seventeen patients with cervical carcinoma FIGO stage IB2-IIIB were treated with curative intent between 2011 and 2015...
December 22, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29233573/re-irradiation-in-gynaecological-malignancies-a-review
#14
A H Sadozye
Re-irradiation in gynaecological malignancies has become an increasingly frequent consideration. This can be delivered in multiple settings, with the most common being a patient with a history of cervical cancer developing a new vaginal cancer or endometrial cancer with local recurrence after hysterectomy and adjuvant pelvic radiation. A systematic review of the literature has unearthed a handful of reports, most delivering brachytherapy, with a small number on both external beam radiotherapy and stereotactic ablative radiotherapy...
February 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29223302/modeling-the-target-dose-fall-off-in-imrt-and-vmat-planning-techniques-for-cervical-sbrt
#15
A Brito Delgado, D Cohen, T Y Eng, D N Stanley, Z Shi, M Charlton, A N Gutiérrez
There has been growing interest in the use of stereotactic body radiotherapy (SBRT) technique for the treatment of cervical cancer. The purpose of this study was to characterize dose distributions as well as model the target dose fall-off for intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) delivery techniques using 6 and 10 MV photon beam energies. Fifteen (n = 15) patients with non-bulky cervical tumors were planned in Pinnacle3 with a Varian Novalis Tx (HD120 MLC) using 6 and 10 MV photons with the following techniques: (1) IMRT with 10 non-coplanar beams (2) dual, coplanar 358° VMAT arcs (4° spacing), and (3) triple, non-coplanar VMAT arcs...
December 6, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29214646/endoscopic-sentinel-lymph-node-biopsy-using-indocyanine-green-neomannosyl-human-serum-albumin
#16
Young Min Park, Yu Hua Quan, Ki Hyeok Kwon, Jae-Gu Cho, Jeong-Soo Woo, Beop-Min Kim, Yun-Sang Lee, Jae Min Jeong, Hyun Koo Kim, Jae-Jun Song
OBJECTIVE: The aim of this study was to determine the possibility of endoscopic sentinel lymph node biopsy of the head and neck region using indocyanine green-neomannosyl human serum albumin (ICG:MSA) and a custom-made intraoperative color-and-fluorescence-merged imaging system (ICFIS). METHODS: Using mouse and rabbit models of tongue cancer, we performed sentinel lymph node biopsy using an ICG:MSA tracer and custom imaging system equipped with an endoscope. RESULTS: ICG:MSA was localized to the cervical lymph node on the ipsilateral side for up to 30 minutes compared to ICG tracer (ICG n = 3, IGC:MSA n = 3)...
December 7, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29208514/fragmentation-level-determines-mitochondrial-damage-response-and-subsequently-the-fate-of-cancer-cells-exposed-to-carbon-ions
#17
Xiaodong Jin, Xiaogang Zheng, Feifei Li, Bingtao Liu, Hongbin Li, Ryoichi Hirayama, Ping Li, Xiongxiong Liu, Guosheng Shen, Qiang Li
OBJECTIVES: Although mitochondria are known to play an important role in radiation-induced cellular damage response, the mechanisms of how radiation elicits mitochondrial responses are largely unknown. MATERIALS AND METHODS: Human cervical cancer cell line HeLa and human breast cancer cell lines MCF-7 and MDA-MB-231 were irradiated with high LET carbon ions at low (0.5 Gy) and high (3 Gy) doses. Mitochondrial functions, dynamics, mitophagy, intrinsic apoptosis and total apoptosis, and survival fraction were investigated after irradiation...
December 2, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29206662/surgery-versus-radiation-treatment-for-high-grade-neuroendocrine-cancer-of-uterine-cervix-a-surveillance-epidemiology-and-end-results-database-analysis
#18
Wei-Hsien Hou, Tim E Schultheiss, Jeffrey Y Wong, Mark T Wakabayashi, Yi-Jen Chen
OBJECTIVES: The objective of this study was to assess treatment and other factors impacting survival in cervical high-grade neuroendocrine carcinoma (HGNEC). METHODS/MATERIALS: We identified patients with cervical HGNECs diagnosed during 1988 to 2012 in the Surveillance Epidemiology and End Results database. We determined overall survival by International Federation of Gynecology and Obstetrics stages and by local treatment modalities, that is, radical surgery versus external beam radiation treatment (EBRT) plus brachytherapy using Kaplan-Meier analysis with log-rank test...
January 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29204168/pre-plan-technique-feasibility-in-multi-interstitial-endocavitary-perineal-gynecological-brachytherapy
#19
Silvia Rodriguez, Antonio Otal, Jose Richart, Jose Perez-Calatayud, Manuel Santos
Purpose: To present the implementation of a magnetic resonance imaging (MRI) pre-planning technique in multi-interstitial perineal and endocavitary gynecological brachytherapy. Material and methods: We used a new fully MRI-compatible applicator that is capable to engage titanium needles, and an intrauterine tandem, developed in our department for the treatment of gynecological cervical cancer patients. This applicator is an attempt to combine the technical advantages of the Martinez universal perineal interstitial template (MUPIT) with the improvement in dose distribution by adding an intrauterine probe with the imaging advantages of MRI-based brachytherapy, thus preserving the stability, geometry, and robustness of the implant, avoiding possible errors of free-hand needle placement...
October 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29189448/tumor-boost-using-external-beam-radiation-in-cervical-cancer-patients-unable-to-receive-intracavitary-brachytherapy-outcome-from-a-multicenter-retrospective-study-korean-radiation-oncology-group-1419
#20
Haeyoung Kim, Young Seok Kim, Ji Hyeon Joo, Keun-Yong Eom, Won Park, Jin Hee Kim, Jong Hoon Lee, Yeon Sil Kim, Seok Ho Lee, Kijung Ahn, Yong Bae Kim, Me-Yeon Lee, Sei Kyung Chang
PURPOSE: We conducted this study to evaluate the outcomes of external-beam radiotherapy tumor boost (EBRT-B) in cervical cancer patients who could not receive intracavitary brachytherapy. METHODS: A total of 11 hospitals provided the data of patients who received EBRT-B during the period from January 2005 through October 2012. RESULTS: A total of 75 patients were included. The median radiotherapy dose was 46 Gy (range, 40-54 Gy) for whole pelvis and 24 Gy (range, 9-35 Gy) for EBRT-B...
November 17, 2017: International Journal of Gynecological Cancer
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