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https://www.readbyqxmd.com/read/28211638/the-relationship-between-ovarian-function-and-ovarian-limited-dose-in-radiotherapy-postoperation-of-ovarian-transposition-in-young-patients-with-cervical-cancer
#1
Zhenhua Du, Hui Qu
In this study, the relationship between ovarian function and ovarian limited dose in radiotherapy was evaluated in young patients with cervical cancer who underwent ovarian transposition (Fig1B). Moreover, the novel ovarian dose limit for a better preservation of ovarian function in intensity-modulated radiation therapy (IMRT) was determined. We retrospectively analyzed data from 86 patients with cervical cancer who received radical hysterectomy and ovarian transposition from January 2013 to June 2015. In agreement with the National Comprehensive Cancer Network Guidelines (NCCN) for Cervical Cancer Version 2...
February 17, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28191672/presence-of-cutaneous-human-papillomavirus-dna-in-squamous-cell-carcinoma-of-the-scalp-a-case-series
#2
M La Placa, S Venturoli, D Barbieri, M Nocera, A Patrizi, M P Landini, P A Fanti, E Dika
Various hypotheses have been put forward on the pathogenesis of squamous cell carcinoma (SCC), including chronic sun damage and exposure to ultraviolet radiation (UVR), chemicals, smoking, immunosuppressive medications and human papillomavirus (HPV)(1) . It is well known that alpha (mucosal) HPV types, in particular HPV-16 and HPV-18, are etiologically correlated to cervical cancer and other types of anogenital carcinoma and oropharyngeal papillomatosis(1) . On the contrary, the pathogenesis of squamous cell carcinoma (SCC) outside the mucosae remains obscure, and the link with HPVs has been demonstrated only in the epidermodysplasia verruciformis context(2-3) ...
February 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28187100/prognostic-significance-of-the-standardized-uptake-value-of-pretherapeutic-18f-labeled-2-fluoro-2-deoxyglucose-positron-emission-tomography-computed-tomography-in-patients-with-locally-advanced-cervical-cancer
#3
Ajit Gubbi, Shimoni Kacheria, Sarfraz Ahmad, Nicole M Stavitzski, James E Kendrick
OBJECTIVES: To determine the prognostic significance of the pretreatment and posttreatment maximum standardized uptake value (SUVmax) of F-labeled 2-fluoro-2-deoxyglucose positron emission tomography (PET)/computed tomography imaging in patients with stage IB2-IVA cervical cancer. METHODS: This was a retrospective review of cervical cancer patients with International Federation of Gynecology and Obstetrics stages IB2-IVA, from March 2008 to April 2014. All patients had pretreatment and posttreatment PET imaging and received primary whole pelvic radiation therapy with concurrent radiosensitizing chemotherapy, followed by intracavitary brachytherapy...
March 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28184999/rosiglitazone-enhances-radiosensitivity-by-inhibiting-repair-of-dna-damage-in-cervical-cancer-cells
#4
Zhengzhe An, Jae-Ran Yu, Woo-Yoon Park
Radiation therapy (RT) is one of the main treatment modalities for cervical cancer. Rosiglitazone (ROSI) has been reported to have antiproliferative effects against various types of cancer cells and also to induce antioxidant enzymes that can scavenge reactive oxygen species (ROS) and thereby modify radiosensitivity. Here, we explored the effect of ROSI on radiosensitivity and the underlying mechanisms in cervical cancer cells. Three cervical cancer cell lines (ME-180, HeLa, and SiHa) were used. The cells were pretreated with ROSI and then irradiated...
February 9, 2017: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/28178762/pet-trumps-surgical-staging-in-locally-advanced-cervical-cancer
#5
Leigh A Cantrell, Linda R Duska
Locally advanced cervical cancer (LACC) is a significant problem. The status of the para-aortic lymph nodes (PALN) in women with LACC is critical, as positive PALN dictate extended radiation fields and portend a dismal prognosis. Since 10-25% of women with LACC will have PALN metastases (S Gout, et al. Lancet Oncol 13(5) 2012), the ideal method to identify and treat them is paramount. This article is protected by copyright. All rights reserved.
February 8, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28178757/locally-advanced-cervix-cancer-staging-by-scan-or-by-surgery
#6
Jeroen H Becker, Rene H M Verheijen
In this study the authors try to elucidate the existing uncertainties on imaging versus surgically staging of para-aortic lymph node involvement in locally advanced cervical cancer. In previous studies, as summarized in this new study, it remained undecided whether imaging would suffice to detect lymph node metastases in order to determine the extent of the radiation field, specifically to the para-aortic area. This article is protected by copyright. All rights reserved.
February 8, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28169196/patterns-of-care-of-cervical-cancer-in-the-elderly-a-qualitative-literature-review
#7
Venkatesulu Bhanu Prasad, Supriya Mallick, G K Rath
INTRODUCTION: Cancer of the uterine cervix is the fourth most common cancer worldwide among women. However, there is limited data about elderly cervical cancer patients and gross underrepresentation of elderly patients in clinical trials. Hence, the optimal therapy of such patients is not well formulated. METHODOLOGY: We conducted this systematic review of evidence to assess patterns of care in elderly patients with cervical cancer. RESULTS: A total of 17,338 publications are reported in PubMed until July, 2016 pertaining to cervical cancer...
February 3, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28168125/role-of-gamma-knife%C3%A2-radiosurgery-for-the-treatment-of-brain-metastases-from-gynecological-cancers
#8
Andrew Keller, Rahim Ismail, Peter S Potrebko, Julie Pepe, Meiling Wu, Kunal Saigal, Matthew Biagioli, Ravi Shridhar, Robert Holloway, Melvin Field, Nikhil G Rao
OBJECTIVE: Gamma Knife(®) (GK) (Elekta Instruments, Stockholm, Sweden) radiosurgery is well established for treatment of brain metastases. There are limited data on patients treated with GK from gynecological cancers. The authors sought to determine the effectiveness of the GK in patients with brain metastases from gynecological cancers. METHODS: An IRB-approved database was queried for patients with gynecologic cancers treated with GK between June 1996 and May 2016...
December 31, 2016: Curēus
https://www.readbyqxmd.com/read/28161495/should-the-presence-of-metastatic-para-aortic-lymph-nodes-in-locally-advanced-cervical-cancer-lead-to-more-aggressive-treatment-strategies
#9
Virginia Benito, Sonia Carballo, Patricia Silva, Miriam Esparza, Octavio Arencibia, Mario Federico, Miguel Andújar, Marta Mori, Norberto Medina, Amina Lubrano
OBJECTIVE: To evaluate risk factors in patients with locally advanced cervical cancer (LACC) undergoing pretherapeutic laparoscopic paraaortic lymphadenectomy (LPL), as well as the progression-free and overall survival rates specifically in the subgroup of patients with metastatic paraaortic lymph nodes (PLN). DESIGN: Retrospective study conducted on demographic data, pathological and surgical findings, complications and disease-status, recorded for LACC patients undergoing LPL during the period 2009-2015...
February 1, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28151724/impact-of-dose-escalation-and-adaptive-radiotherapy-for-cervical-cancers-on-tumour-shrinkage-a-modelling-study
#10
Marius Røthe Arnesen, Taran Hellebust, Eirik Malinen
Tumour shrinkage occurs during fractionated radiotherapy and is regulated by radiation induced cellular damage, repopulation of viable cells and clearance of dead cells. In some cases additional tumour shrinkage during external beam therapy may be beneficial, particularly for locally advanced cervical cancer where a small tumour volume may simplify and improve brachytherapy. In the current work, a mathematical tumour model is utilized to investigate how local dose escalation affects tumour shrinkage, focusing on implications for brachytherapy...
February 2, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28150398/c-myc-regulates-radiation-induced-g2-m-cell-cycle-arrest-and-cell-death-in-human-cervical-cancer-cells
#11
Fengmei Cui, Jun Hou, Chengcheng Huang, Xiujin Sun, Yanan Zeng, Huiying Cheng, Hao Wang, Chao Li
AIM: The study was conducted to investigate the role of c-Myc in the regulation of ionizing radiation-induced cell cycle arrest and cell death in human cervical cancer cells. METHODS: Control and c-Myc-silenced Hela cells were collected at different time points after (60) Co γ-ray radiation. Flow cytometry was used to measure cell cycle distribution and apoptosis. Immunofluorescence was applied to determine the percentage of cells in M phase. Transmission electron microscopy and immunoblotting were used to detect the induction of autophagy after radiation...
February 2, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28143506/utilization-of-ct-scanning-associated-with-complex-spine-surgery
#12
Vikas V Patel, Gunnar B J Andersson, Steven R Garfin, Donald L Resnick, Jon E Block
BACKGROUND: Due to the risk associated with exposure to ionizing radiation, there is an urgent need to identify areas of CT scanning overutilization. While increased use of diagnostic spinal imaging has been documented, no previous research has estimated the magnitude of follow-up imaging used to evaluate the postoperative spine. METHODS: This retrospective cohort study quantifies the association between spinal surgery and CT utilization. An insurance database (Humana, Inc...
January 31, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28142146/incidence-of-histologically-proven-pelvic-and-para-aortic-lymph-node-metastases-and-rate-of-upstaging-in-patients-with-locally-advanced-cervical-cancer-results-of-a-prospective-randomized-trial
#13
Audrey Tieko Tsunoda, Simone Marnitz, Joao Soares Nunes, Carlos Eduardo Mattos de Cunha Andrade, Christovam Scapulatempo Neto, Jens-Uwe Blohmer, Jörg Herrmann, Ligia Maria Kerr, Peter Martus, Achim Schneider, Giovanni Favero, Christhardt Köhler
BACKGROUND: Surgical staging is associated with a significant rate of upstaging compared to clinical/radiological staging in patients with locally advanced cervical cancer. OBJECTIVE: To analyze the stage-specific percentage of pelvic and para-aortic lymph node metastases and the upstaging ratio in a prospective randomized trial (Uterus-11). METHODS: FIGO stage IIB-IVA cervical cancer patients were randomized to surgical staging (arm A) or to clinical staging and primary chemoradiation (arm B)...
February 1, 2017: Oncology
https://www.readbyqxmd.com/read/28133333/-a-case-report-of-difficult-esophagojejunal-anastomosis-for-multiple-primary-cancer-of-malignant-lymphoma-and-gastric-cancer
#14
Masanori Yamada, Koji Nakai, Kentaro Inoue, Takeshi Hijikawa, Hiroaki Kitade, Kazuyoshi Ishii, Kazuhiko Yoshioka, Masanori Kon
A 54-year-old man presented with cervical lymph node swelling and exhibited high levels of sIL-2R. Enhanced cervical, chest, and abdominal CT scanning demonstrated swelling of the cervical, hilar, axilla, and abdominal lymph nodes. The patient was diagnosed with malignant, non-Hodgkin's lymphoma, B-cell, follicular lymphoma using biopsy of the cervical lymph nodes. Gastrointestinal endoscopy revealed II c like advanced tumor in the upper gastric body and post-wall area. He was diagnosed with primary multiple cancer comprising malignant lymphoma and gastric cancer...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28126303/bone-marrow-sparing-intensity-modulated-radiation-therapy-with-concurrent-cisplatin-for-stage-ib-iva-cervical-cancer-an-international-multicenter-phase-ii-clinical-trial-intertecc-2
#15
Loren K Mell, Igor Sirák, Lichun Wei, Rafal Tarnawski, Umesh Mahantshetty, Catheryn M Yashar, Michael T McHale, Ronghui Xu, Gordon Honerkamp-Smith, Ruben Carmona, Mary Wright, Casey W Williamson, Linda Kasaová, Nan Li, Stephen Kry, Jeff Michalski, Walter Bosch, William Straube, Julie Schwarz, Jessica Lowenstein, Steve B Jiang, Cheryl C Saenz, Steve Plaxe, John Einck, Chonlakiet Khorprasert, Paul Koonings, Terry Harrison, Mei Shi, A J Mundt
PURPOSE: To test the hypothesis that intensity modulated radiation therapy (IMRT) reduces acute hematologic and gastrointestinal (GI) toxicity for patients with locoregionally advanced cervical cancer. METHODS AND MATERIALS: We enrolled patients with stage IB-IVA cervical carcinoma in a single-arm phase II trial involving 8 centers internationally. All patients received weekly cisplatin concurrently with once-daily IMRT, followed by intracavitary brachytherapy, as indicated...
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28124532/the-burden-of-chronic-ureteral-stenting-in-cervical-cancer-survivors
#16
Robert A Goldfarb, Yunhua Fan, Stephanie Jarosek, Sean P Elliott
PURPOSE: Ureteral obstruction in cervical cancer occurs in up to 11% of patients, many of whom undergo ureteral stenting. Our aim was to describe the patient burden of chronic ureteral stenting in a population-based cohort by detailing two objectives: (1) the frequency of repeat procedures for ureteral obstruction; and, (2) the frequency of urinary adverse effects (UAEs) (e.g., lower urinary tract symptoms, flank pain). MATERIALS AND METHODS: From SEER-Medicare, we identified 202 women who underwent ureteral stent placement prior to or following cervical cancer treatment...
January 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28118119/stomach-cancer-following-hodgkin-lymphoma-testicular-cancer-and-cervical-cancer-a-pooled-analysis-of-three-international-studies-with-a-focus-on-radiation-effects
#17
Ethel S Gilbert, Rochelle E Curtis, Michael Hauptmann, Ruth A Kleinerman, Charles F Lynch, Marilyn Stovall, Susan A Smith, Rita Weathers, Michael Andersson, Graça M Dores, Joseph F Fraumeni, Sophie D Fossa, Per Hall, David C Hodgson, Eric J Holowaty, Heikki Joensuu, Tom B Johannesen, Froydis Langmark, Magnus Kaijser, Eero Pukkala, Preetha Rajaraman, Hans H Storm, Leila Vaalavirta, Alexandra W van den Belt-Dusebout, Berthe M Aleman, Lois B Travis, Lindsay M Morton, Flora E van Leeuwen
To further understand the risk of stomach cancer after fractionated high-dose radiotherapy, we pooled individual-level data from three recent stomach cancer case-control studies. These studies were nested in cohorts of five-year survivors of first primary Hodgkin lymphoma (HL), testicular cancer (TC) or cervical cancer (CX) from seven countries. Detailed data were abstracted from patient records and radiation doses were reconstructed to the site of the stomach cancer for cases and to the corresponding sites for matched controls...
January 24, 2017: Radiation Research
https://www.readbyqxmd.com/read/28116341/concurrent-chemoradiation-versus-radiotherapy-alone-for-the-treatment-of-locally-advanced-cervical-cancer-in-a-low-resource-setting
#18
Elena Pereira, Hoover Henriquez Cooper, Pedro Guillermo Zelaya, William Creasman, Fredric V Price, Vishal Gupta, Linus Chuang
Our goal was to determine the clinical treatment response following radiation administered with or without chemotherapy for locally advanced cervical cancers in Honduras. This is a retrospective study of patients treated with either concurrent chemoradiation (CCRT) or external beam radiation therapy (EBRT) alone at a hospital in Tegucigalpa, Honduras. 70 Gy of EBRT to the pelvis was given in all cases. Brachytherapy was not available. Chemotherapy was given when available. Extrafascial hysterectomy was performed 6 weeks after completion of treatment in patients with a complete clinical response (cCR)...
February 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28115961/encrusted-cystitis-after-definitive-radiotherapy-for-cervical-cancer-a-case-report
#19
Elisabetta Perrucci, Valentina Lancellotta, Maika di Benedetto, Isabella Palumbo, Fabio Matrone, Marino Chiodi, Riccardo Lombi, Marta Marcantonini, Cristina Mariucci, Cynthia Aristei
PURPOSE: Encrusted cystitis is a rare chronic inflammatory disease characterized by calcified plaques of the bladder, previously altered by varies conditions as urological procedures, caused by urea-splitting bacteria. Only one case has been reported on encrusted cystitis occurring after surgery and radiation therapy for a pelvic neoplasm. We report on encrusted cystitis occurred after definitive radiotherapy for bulky uterine cervix cancer, and examine the doses to the bladder wall and the procedure of radiation treatment performed as a possible cause of the onset of the disease...
December 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28115959/model-assessment-of-individual-tumor-control-rate-and-adverse-effects-in-comparing-locally-advanced-cervical-cancer-treatment-using-intracavitary-with-and-without-interstitial-brachytherapy
#20
Hsiang-Chi Kuo, Keyur J Mehta, Ravindra Yaparpalvi, Viswanathan Shankar, William Bodner, Madhur Garg, Amanda Rivera, Wolfgang A Tomé, Shalom Kalnicki
PURPOSE: This study assessed the modeled probability of tumor control and organ at risk toxicities in locally advanced cervical cancer in patients treated by external beam radiation plus brachytherapy using intracavitary combined with interstitial brachytherapy (IC/IS) vs. intracavitary brachytherapy (IC) alone. MATERIAL AND METHODS: Twenty cervical cancer patients with a mean HR-CTV volume of 47.4 cm(3) and a mean width of 54 mm were planned with both IC/IS and IC brachytherapy alone...
December 2016: Journal of Contemporary Brachytherapy
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