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https://www.readbyqxmd.com/read/28731438/evidence-that-the-human-innate-immune-peptide-ll-37-may-be-a-binding-partner-of%C3%A2-amyloid-%C3%AE-and-inhibitor-of%C3%A2-fibril-assembly
#1
Ersilia De Lorenzi, Marcella Chiari, Raffaella Colombo, Marina Cretich, Laura Sola, Renzo Vanna, Paola Gagni, Federica Bisceglia, Carlo Morasso, Jennifer S Lin, Moonhee Lee, Patrick L McGeer, Annelise E Barron
BACKGROUND: Identifying physiologically relevant binding partners of amyloid-β (Aβ) that modulate in vivo fibril formation may yield new insights into Alzheimer's disease (AD) etiology. Human cathelicidin peptide, LL-37, is an innate immune effector and modulator, ubiquitous in human tissues and expressed in myriad cell types. OBJECTIVE: We present in vitro experimental evidence and discuss findings supporting a novel hypothesis that LL-37 binds to Aβ42 and can modulate Aβ fibril formation...
July 18, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28731286/impact-of-fluorine-atoms-on-perylene-diimide-derivative-for-fullerene-free-organic-photovoltaics
#2
Liang Zhao, Hua Sun, Xiaoyuan Liu, Changmei Liu, Haiquan Shan, Jiuxu Xia, Zongxiang Xu, Fei Chen, Zhi-Kuan Chen, Wei Huang
The incorporation of fluorine atoms in organic semiconducting materials has attracted much attention recently due to its unique function to manipulate the molecular packing, film morphology and molecular energy levels. In this work, two perylenediimide (PDI) derivatives FPDI-CDTph and FPDI-CDTph2F were designed and synthesized to investigate the impact of fluorination on non-fullerene acceptors. Both FPDI-CDTph and FPDI-CDTph2F exhibited strong and broad absorption profiles, suitable lowest unoccupied molecular orbital (LUMO) and highest occupied molecular orbital (HOMO) energy levels, and good electron transport ability...
June 14, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28730873/physiological-traits-determining-yield-tolerance-of-wheat-to-foliar-diseases
#3
Femke van den Berg, Neil Paveley, I J Bingham, Frank van den Bosch
Tolerance is defined as the ability of one cultivar to yield more than another cultivar, under similar disease severity. If both cultivars suffer an equal loss in healthy (green) leaf area duration (HAD) over the grain filling period due to disease presence, then the yield loss per unit HAD loss is smaller for a more tolerant cultivar. Little is understood of what physiological and developmental traits of cultivars determine disease tolerance. In this study we use a mathematical model of wheat to investigate the effect of a wide range of wheat phenotypes on tolerance...
July 21, 2017: Phytopathology
https://www.readbyqxmd.com/read/28729218/spectroscopic-study-of-fluorescent-probes-based-on-g-quadruplex-oligonucleotides-labeled-with-ethynylpyrenyldeoxyuridine
#4
Angelika Switalska, Ryszard Kierzek, Anna Dembska, Bernard Juskowiak
The design, synthesis, and spectral properties of four pyrene labeled oligonucleotide probes with G-quadruplex structure (Tel22-Tpy, Tel22-Upy, Tel22-6Upy, Tel22-18Upy) based on the 22-mer human telomeric sequence (Tel22) have been reported. Pyrene labels in the form of ethynylpyrenyldeoxyuridine have been inserted efficiently into oligodeoxynucleotides probes using phosphoramidite chemistry. The probes exhibited abilities to fold into G-quadruplex structures and to bind metal cations (Na(+) and K(+)). Folding properties of probes and their spectral behavior were examined by recording the UV-Vis, fluorescence, and CD spectra as well as by analyzing melting profiles...
July 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28727890/surfactant-concentration-and-type-affects-the-removal-of-escherichia-coli-from-pig-skin-during-a-simulated-handwash
#5
Dane A Jensen, Michael A Rogers, Donald W Schaffner
The effect of surfactant type and concentration on a bland soap formulations ability to remove bacteria from hands remains largely unstudied. Several combinations of surfactants and water were combined to test bacterial removal efficacy using a handwashing device (two pieces of pig skin and a mechanical motor) to simulate a handwash. A nalidixic acid resistant, non-pathogenic strain of Escherichia coli (ATCC 11229) was used. Two anionic surfactants, sodium lauryl sulfate and sodium stearoyl lactylate, and two nonionic surfactants, poloxamer 407 and sorbitan monostearate, each in concentrations of 2%, 5%, and 10% were studied...
July 20, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28727737/improving-deep-convolutional-neural-networks-with-mixed-maxout-units
#6
Hui-Zhen Zhao, Fu-Xian Liu, Long-Yue Li
Motivated by insights from the maxout-units-based deep Convolutional Neural Network (CNN) that "non-maximal features are unable to deliver" and "feature mapping subspace pooling is insufficient," we present a novel mixed variant of the recently introduced maxout unit called a mixout unit. Specifically, we do so by calculating the exponential probabilities of feature mappings gained by applying different convolutional transformations over the same input and then calculating the expected values according to their exponential probabilities...
2017: PloS One
https://www.readbyqxmd.com/read/28727674/the-community-balance-and-mobility-scale-a-valid-assessment-tool-of-balance-in-cardiac-rehabilitation-patients
#7
Luke Martelli, Dave Saraswat, Gail Dechman, Nicholas B Giacomantonio, Scott A Grandy
PURPOSE: Many patients participating in cardiac rehabilitation (CR) programs have decreased balance. This is a concern, as it may affect their ability to optimally perform physical exercise in CR and thus decrease CR efficacy. Despite this concern, balance is typically not assessed as part of CR intake. This may be attributable to the fact that a suitable balance assessment tool has not been identified for higher-functioning CR patients. A potential solution to this issue is using the Community Balance and Mobility Scale (CBMS), which has been used to assess balance in higher-functioning clinical populations; however, its use in a CR population has never been investigated...
July 19, 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28725111/oxidative-stress-and-food-supplementation-with-antioxidants-in-therapy-dogs
#8
Sara Sechi, Filippo Fiore, Francesca Chiavolelli, Corrado Dimauro, Anna Nudda, Raffaella Cocco
The objective of this study was to evaluate the ability of a long-term antioxidant-supplemented diet to regulate the oxidative stress and general health status of dogs involved in animal-assisted intervention (AAI) programs. Oxidative stress is a consequence of the accumulation of reactive oxygen species (ROS). Exercise-induced oxidative stress can increase muscle fatigue and fiber damage and eventually leads to impairment of the immune system. A randomized, placebo-controlled, crossover clinical evaluation was conducted with 11 healthy therapy dogs: 6 females and 5 males of different breeds and with a mean age of 2...
July 2017: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/28724855/decreased-fatty-acid-%C3%AE-oxidation-is-the-main-cause-of-fatty-liver-induced-by-polyunsaturated-fatty-acid-deficiency-in-mice
#9
Takero Nakajima, Yang Yang, Yu Lu, Yuji Kamijo, Yosuke Yamada, Kozo Nakamura, Masahiro Koyama, Shohei Yamaguchi, Eiko Sugiyama, Naoki Tanaka, Toshifumi Aoyama
Insufficient intake of polyunsaturated fatty acids (PUFA) causes fatty liver. The mechanism responsible is primarily related to increased lipogenesis and decreased FA degradation based on rodent studies. However, these studies were limited by the fact that the typical PUFA-deficient diets contained insufficient amounts of long-chain FA, the PUFA-containing diets were primarily composed of n-3 PUFA-enriched oil, and the intake of PUFA was excessive compared with the physiological requirement. To address these issues, mice were fed a PUFA-deficient diet containing long-chain FA at a standard fed level and then were orally fed a n-3/n-6-balanced PUFA-containing oil [PUFA (+)] or a PUFA-deficient oil [PUFA (-)] at physiological relevant levels (0...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28724227/carbon-and-nitrogen-allocation-strategy-in-posidonia-oceanica-is-altered-by-seawater-acidification
#10
Andrea Scartazza, Stefano Moscatello, Olga Gavrichkova, Maria Cristina Buia, Marco Lauteri, Alberto Battistelli, Maurizio Lorenti, Samantha Laird Garrard, Carlo Calfapietra, Enrico Brugnoli
Rising atmospheric CO2 causes ocean acidification that represents one of the major ecological threats for marine biota. We tested the hypothesis that long-term exposure to increased CO2 level and acidification in a natural CO2 vent system alters carbon (C) and nitrogen (N) metabolism in Posidonia oceanica L. (Delile), affecting its resilience, or capability to restore the physiological homeostasis, and the nutritional quality of organic matter available for grazers. Seawater acidification decreased the C to N ratio in P...
July 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28723916/stakeholders-views-and-experiences-of-care-and-interventions-for-addressing-frailty-and-pre-frailty-a-meta-synthesis-of-qualitative-evidence
#11
Barbara D'Avanzo, Rachel Shaw, Silvia Riva, Joao Apostolo, Elzbieta Bobrowicz-Campos, Donata Kurpas, Maria Bujnowska, Carol Holland
Frailty is a common condition in older age and is a public health concern which requires integrated care and involves different stakeholders. This meta-synthesis focuses on experiences, understanding, and attitudes towards screening, care, intervention and prevention for frailty across frail and healthy older persons, caregivers, health and social care practitioners. Studies published since 2001 were identified through search of electronic databases; 81 eligible papers were identified and read in full, and 45 papers were finally included and synthesized...
2017: PloS One
https://www.readbyqxmd.com/read/28723095/facile-and-low-temperature-fabrication-of-thermochromic-cr2o3-vo2-smart-coatings-enhanced-solar-modulation-ability-high-luminous-transmittance-and-uv-shielding-function
#12
Tianci Chang, Xun Cao, Ning Li, Shiwei Long, Xiang Gao, Liv R Dedon, Guangyao Sun, Hongjie Luo, Ping Jin
In the pursuit of energy efficient materials, vanadium dioxide (VO2) based smart coatings have gained much attention in recent years. For smart window applications, VO2 thin films should be fabricated at low temperature to reduce the cost in commercial fabrication and solve compatibility problems. Meanwhile, thermochromic performance with high luminous transmittance and solar modulation ability as well as effective UV shielding function has become the most important developing strategy for ideal smart windows...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28721857/stress-adaptation
#13
Alistair J P Brown, Leah E Cowen, Antonio di Pietro, Janet Quinn
Fungal species display an extraordinarily diverse range of lifestyles. Nevertheless, the survival of each species depends on its ability to sense and respond to changes in its natural environment. Environmental changes such as fluctuations in temperature, water balance or pH, or exposure to chemical insults such as reactive oxygen and nitrogen species exert stresses that perturb cellular homeostasis and cause molecular damage to the fungal cell. Consequently, fungi have evolved mechanisms to repair this damage, detoxify chemical insults, and restore cellular homeostasis...
July 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28720186/flight-performance-during-exposure-to-acute-hypobaric-hypoxia
#14
Yuval Steinman, Marieke H A H van den Oord, Monique H W Frings-Dresen, Judith K Sluiter
INTRODUCTION: The purpose of the present study was to examine the influence of hypobaric hypoxia (HH) on a pilot's flight performance during exposure to simulated altitudes of 91, 3048, and 4572 m (300, 10,000, and 15,000 ft) and to monitor the pilot's physiological reactions. METHOD: In a single-blinded counter-balanced design, 12 male pilots were exposed to HH while flying in a flight simulator that had been placed in a hypobaric chamber. Flight performance of the pilots, pilot's alertness level, Spo2, heart rate (HR), minute ventilation (VE), and breathing frequency (BF) were measured...
August 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28720023/early-motor-development-and-cognitive-abilities-among-mexican-preschoolers
#15
Erika Osorio-Valencia, Luisa Torres-Sánchez, Lizbeth López-Carrillo, Stephen J Rothenberg, Lourdes Schnaas
Psychomotricity plays a very important role in children's development, especially for learning involving reading-writing and mathematical calculations. Evaluate motor development in children 3 years old and its relationship with their cognitive abilities at the age of 5 years. Based on a cohort study, we analyzed the information about motor performance evaluated at 3 years old by Peabody Motor Scale and cognitive abilities at 5 years old. The association was estimated using linear regression models adjusted by mother's intelligence quotient, sex, Bayley mental development index at 18 months, and quality of the environment at home (HOME scale)...
July 18, 2017: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/28718514/aldehyde-dehydrogenase-1-a1-regulates-energy-metabolism-in-adipocytes-from-different-species
#16
Kefeng Yang, Christopher Adin, Qiwen Shen, Ly James Lee, Lianbo Yu, Paolo Fadda, Arpad Samogyi, Kathleen Ham, Lu Xu, Chen Gilor, Ouliana Ziouzenkova
BACKGROUND: Survival and longevity of xenotransplants depend on immune function and ability to integrate energy metabolism between cells from different species. However, mechanisms for interspecies cross talk in energy metabolism are not well understood. White adipose tissue stores energy and is capable of mobilization and dissipation of energy as heat (thermogenesis) by adipocytes expressing uncoupling protein 1 (Ucp1). Both pathways are under the control of vitamin A metabolizing enzymes...
July 17, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/28718292/structural-characterization-of-ordered-non-close-packed-functionalized-silica-nanoparticles-on-gold-surfaces
#17
Christian Grunewald, Madlen Schmudde, Christina Graf, Thomas Risse
Nanostructured surfaces play an important role in modern science and technology. In particular, ordered arrangements of nonclose-packed nanoparticles created by self-assembly offer a versatile route to prepare systems, which can be used in various applications such as sensing, plasmonic devices or antireflection coatings. Self-assembly based systems are particularly appealing as preparation is rather simple. The ability of nanoparticle systems to form nonclosed packed monolayers by self-assembly depends on the balance of various energetic contributions in particular the adsorption energy, the lateral barrier for diffusion and the repulsion between particles...
July 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28717805/relationship-between-diet-related-indicators-and-overweight-and-obesity-in-older-adults-in-rural-japan
#18
M Ishikawa, S Moriya, T Yokoyama
OBJECTIVES: To identify the relationship between diet-related indicators and overweight and obesity in older adults in rural Japan. DESIGN: Cross-sectional survey. SETTING: Obira, Hokkaido, Japan. PARTICIPANTS: Local residents aged between 65 and 74 years, except for those with poor health, were included. INTERVENTION: A health- and diet-related questionnaire was applied to participants house-to-house by trained health professionals...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28717152/effects-of-population-bottleneck-and-balancing-selection-on-the-chinese-alligator-are-revealed-by-locus-specific-characterization-of-mhc-genes
#19
Teng Zhai, Hai-Qiong Yang, Rui-Can Zhang, Li-Ming Fang, Guo-Heng Zhong, Sheng-Guo Fang
Chinese alligator (Alligator sinensis) is an endangered freshwater crocodilian endemic to China, which experienced a severe bottleneck about 30 years ago. In this study, we developed locus-specific primers to investigate the polymorphism of 3 major histocompatibility complex (MHC) loci in 3 Chinese alligator populations, in combination with 6 neutral microsatellite markers as a contrast. We found the genetic trace for the bottleneck effect on the endangered Chinese alligator: the low allelic diversity (2 alleles at each locus), the low nucleotide substitution rate (no more than 0...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28715271/comparison-of-trunk-impairment-scale-versions-1-0-and-2-0-in-people-with-multiple-sclerosis-a-validation-study
#20
Ylva Nilsagård, Anna Carling, Oskar Davidsson, Lisbeth Franzén, Anette Forsberg
BACKGROUND: Trunk control impairment often accompanies multiple sclerosis (MS). Trunk stability is necessary for movements of extremities, as are selective trunk movements for normal gait. Measuring trunk function is thus of interest. METHODS: We examined the relationships between the Trunk Impairment Scale (TIS1.0 and TIS2.0) and the Berg Balance Scale (BBS), 5 sit-to-stand test (5STS), Timed Up and Go test (TUG), 10-m timed walk test (10TW), 2-min walk test (2MWT), Falls Efficacy Scale - International, and 12-item MS Walking Scale (MSWS-12) in 47 outpatients...
July 17, 2017: Physiotherapy Theory and Practice
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