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https://www.readbyqxmd.com/read/29474692/commonalities-and-differences-in-controlling-multipartite-intracellular-infections-of-legume-roots-by-symbiotic-microbes
#1
Beatrice Lace, Thomas Ott
Legumes have the almost unique ability to establish symbiotic associations with rhizobia and arbuscular mycorrhizal fungi. Forward and reverse genetics have identified a large number of genes that are required for either or both interactions. However, and in sharp contrast to natural soils, these interactions have been almost exclusively investigated under laboratory conditions by using separate inoculation systems, whereas both symbionts are simultaneously present in the field. Considering our recent understanding of the individual symbioses the community is now promisingly positioned to co-inoculate plants with two or more microbes in order to mechanistically understand how legumes efficiently balance, regulate and potentially separate these symbioses and other endophytic microbes within the same root...
February 20, 2018: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29474665/catastrophizing-interferes-with-cognitive-modulation-of-pain-in-women-with-fibromyalgia
#2
Laura D Ellingson, Aaron J Stegner, Isaac J Schwabacher, Jacob B Lindheimer, Dane B Cook
Background: Pain modulation is a critical function of the nociceptive system that includes the ability to engage descending pain control systems to maintain a functional balance between facilitation and inhibition of incoming sensory stimuli. Dysfunctional pain modulation is associated with increased risk for chronic pain and is characteristic of fibromyalgia (FM). Catastrophizing is also common in FM. However, its influence on pain modulation is poorly understood. Objective: To determine the role of catastrophizing on central nervous system processing during pain modulation in FM via examining brain responses and pain sensitivity during an attention-distraction paradigm...
February 21, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29474574/evidence-based-medicine-and-big-genomic-data
#3
John P A Ioannidis, Muin J Khoury
Genomic and other related big data (Big Genomic Data, BGD for short) are ushering a new era of precision medicine. This overview discusses whether principles of evidence-based medicine (EBM) hold true for BGD and how they should be operationalized in the current era. Major EBM principles include the systematic identification, description and analysis of the validity and utility of BGD, the combination of individual clinical expertise with individual patient needs and preferences, and the focus on obtaining experimental evidence, whenever possible...
February 20, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29474369/a-comparison-of-balance-control-during-stance-and-gait-in-patients-with-inflammatory-and-non-inflammatory-polyneuropathy
#4
Oliver Findling, Rens van der Logt, Krassen Nedeltchev, Lutz Achtnichts, John H J Allum
INTRODUCTION: We compared changes in balance control due to chronic inflammatory demyelinating polyneuropathy (CIDP) and non-inflammatory (non-inf) polyneuropathy (PNP) to each other and with respect to healthy controls (HCs). Differences in patients' subjective impressions of balance capabilities were also compared. METHODS: Balance control of 11 CIDP patients (mean age 61.1±(sd) 11, 8 male) and 10 non-inf PNP patients (mean age 68.5±11.7, all male) was examined and compared to that of 18 age- and gender-matched healthy controls...
2018: PloS One
https://www.readbyqxmd.com/read/29474129/reliability-validity-and-minimal-detectable-change-of-the-mini-bestest-in-greek-participants-with-chronic-stroke
#5
Sofia I Lampropoulou, Evdokia Billis, Ingrid A Gedikoglou, Christina Michailidou, Alexander V Nowicky, Dimitra Skrinou, Fotini Michailidi, Danae Chandrinou, Margarita Meligoni
OBJECTIVES: This study aimed to investigate the psychometric characteristics of reliability, validity and ability to detect change of a newly developed balance assessment tool, the Mini-BESTest, in Greek patients with stroke. DESIGN: A prospective, observational design study with test-retest measures was conducted. METHODS: A convenience sample of 21 Greek patients with chronic stroke (14 male, 7 female; age of 63 ± 16 years) was recruited...
February 23, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29473778/assessment-of-the-praxis-circuit-in-glioma-surgery-to-reduce-the-incidence-of-postoperative-and-long-term-apraxia-a-new-intraoperative-test
#6
Marco Rossi, Luca Fornia, Guglielmo Puglisi, Antonella Leonetti, Gianmarco Zuccon, Enrica Fava, Daniela Milani, Alessandra Casarotti, Marco Riva, Federico Pessina, Gabriella Cerri, Lorenzo Bello
OBJECTIVE Apraxia is a cognitive-motor deficit affecting the execution of skilled movements, termed praxis gestures, in the absence of primary sensory or motor disorders. In patients affected by stroke, apraxia is associated with lesions of the lateral parietofrontal stream, connecting the posterior parietal areas with the ventrolateral premotor area and subserving sensory-motor integration for the hand movements. In the neurosurgical literature to date, there are few reports regarding the incidence of apraxia after glioma surgery...
February 23, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29473480/dual-task-training-effects-on-motor-and-cognitive-functional-abilities-in-individuals-with-stroke-a-systematic-review
#7
Ying He, Lei Yang, Jing Zhou, Liqing Yao, Marco Yiu Chung Pang
OBJECTIVE: This systematic review aimed to examine the effects of dual-task balance and mobility training in people with stroke. METHODS: An extensive electronic databases literature search was conducted using MEDLINE, PubMed, EBSCO, The Cochrane Library, Web of Science, SCOPUS, and Wiley Online Library. Randomized controlled studies that assessed the effects of dual-task training in stroke patients were included for the review (last search in December 2017). The methodological quality was evaluated using the Cochrane Collaboration recommendation, and level of evidence was determined according to the criteria described by the Oxford Center for Evidence-Based Medicine...
February 1, 2018: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29473346/evaluating-interaction-of-cord-blood-hematopoietic-stem-progenitor-cells-with-functionally-integrated-three-dimensional-microenvironments
#8
Saloomeh Mokhtari, Pedro M Baptista, Dipen A Vyas, Charles Jordan Freeman, Emma Moran, Matthew Brovold, Guillermo A Llamazares, Zanneta Lamar, Christopher D Porada, Shay Soker, Graça Almeida-Porada
Despite advances in ex vivo expansion of cord blood-derived hematopoietic stem/progenitor cells (CB-HSPC), challenges still remain regarding the ability to obtain, from a single unit, sufficient numbers of cells to treat an adolescent or adult patient. We and others have shown that CB-HSPC can be expanded ex vivo in two-dimensional (2D) cultures, but the absolute percentage of the more primitive stem cells decreases with time. During development, the fetal liver is the main site of HSPC expansion. Therefore, here we investigated, in vitro, the outcome of interactions of primitive HSPC with surrogate fetal liver environments...
February 23, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29472164/associations-of-independent-living-and-labor-force-participation-with-impairment-indicators-in-schizophrenia-and-bipolar-disorder-at-20-year-follow-up
#9
M Strassnig, R Kotov, L Fochtmann, M Kalin, E J Bromet, P D Harvey
BACKGROUND: Since the Iowa 500 study, residential and occupational status have been frequently used as indicators of everyday achievements in research on schizophrenia and bipolar disorder. The relationships of residential and occupational status with impairment in multiple domains including physical health indicators across these two diagnoses, however, have rarely been studied. We examined these relationships at the 20-year follow-up assessment of a first-admission sample. METHODS: We included 146 participants with schizophrenia and 87 with bipolar disorder with psychosis who participated in the 20-year follow-up of the Suffolk County Mental Health Project...
February 19, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29470440/membranes-a-variety-of-energy-landscapes-for-many-transfer-opportunities
#10
Patrice Bacchin
A membrane can be represented by an energy landscape that solutes or colloids must cross. A model accounting for the momentum and the mass balances in the membrane energy landscape establishes a new way of writing for the Darcy law. The counter-pressure in the Darcy law is no longer written as the result of an osmotic pressure difference but rather as a function of colloid-membrane interactions. The ability of the model to describe the physics of the filtration is discussed in detail. This model is solved in a simplified energy landscape to derive analytical relationships that describe the selectivity and the counter-pressure from ab initio operating conditions...
February 22, 2018: Membranes
https://www.readbyqxmd.com/read/29470093/hemispheric-asymmetries-in-setticlavio-reading
#11
Anita D'Anselmo, Felice Giuliani, Federica Campopiano, Emanuele Carta, Alfredo Brancucci
Musical setticlavio (literally, seven clefs) reading refers to the ability to read (i.e., to say aloud, without to sing) the musical note labels in the 7 musical clefs. The present research report aims to investigate hemispheric asymmetries in such a basic musical ability, very poorly investigated in the domain of cognitive neurosciences. Sixty-three musicians underwent lateralized tachistoscopic presentation of musical notes on staves, 50% in the left and 50% in the right visual field, associated with each of the 7 musical clefs...
February 22, 2018: Neuropsychology
https://www.readbyqxmd.com/read/29469998/the-effect-of-complete-denture-occlusion-on-function-and-patient-quality-of-life-systematic-review
#12
J Patel, C Granger, L Morrow
Edentulism presents an ongoing challenge for prosthodontic dentistry. Many aspects of complete denture construction lack contemporary evidence. One such aspect is denture occlusion. Balanced occlusion (BO) has become the prevailing occlusal scheme. It has been suggested that canine guidance (CG) is unsuitable for complete denture occlusion due to an increased risk for tipping of the prostheses. However it may be indicated in patients with minimal alveolus resorption. There has been limited evidence suggesting the superiority of either occlusal scheme over another...
February 20, 2018: Community Dental Health
https://www.readbyqxmd.com/read/29468084/a-development-study-and-randomised-feasibility-trial-of-a-tailored-intervention-to-improve-activity-and-reduce-falls-in-older-adults-with-mild-cognitive-impairment-and-mild-dementia
#13
Rowan H Harwood, Veronika van der Wardt, Sarah E Goldberg, Fiona Kearney, Pip Logan, Vicky Hood-Moore, Vicky Booth, Jennie E Hancox, Tahir Masud, Zoe Hoare, Andrew Brand, Rhiannon Tudor Edwards, Carys Jones, Roshan das Nair, Kristian Pollock, Maureen Godfrey, John R F Gladman, Kavita Vedhara, Helen Smith, Martin Orrell
Background: People with dementia progressively lose abilities and are prone to falling. Exercise- and activity-based interventions hold the prospect of increasing abilities, reducing falls, and slowing decline in cognition. Current falls prevention approaches are poorly suited to people with dementia, however, and are of uncertain effectiveness. We used multiple sources, and a co-production approach, to develop a new intervention, which we will evaluate in a feasibility randomised controlled trial (RCT), with embedded adherence, process and economic analyses...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29468039/differences-among-six-woody-perennials-native-to-northern-europe-in-their-level-of-genetic-differentiation-and-adaptive-potential-at-fine-local-scale
#14
Albin Lobo, Jon Kehlet Hansen, Lars Nørgaard Hansen, Erik Dahl Kjær
The ability of perennial species to adapt their phenology to present and future temperature conditions is important for their ability to retain high fitness compared to other competing plant species, pests, and pathogens. Many transplanting studies with forest tree species have previously reported substantial genetic differentiation among populations within their native range. However, the question of "how local is local" is still highly debated in conservation biology because studies on genetic patterns of variation within and among populations at the local scale are limited and scattered...
February 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29467654/the-p2x7-receptor-in-inflammatory-diseases-angel-or-demon
#15
REVIEW
Luiz E B Savio, Paola de Andrade Mello, Cleide Gonçalves da Silva, Robson Coutinho-Silva
Under physiological conditions, adenosine triphosphate (ATP) is present at low levels in the extracellular milieu, being massively released by stressed or dying cells. Once outside the cells, ATP and related nucleotides/nucleoside generated by ectonucleotidases mediate a high evolutionary conserved signaling system: the purinergic signaling, which is involved in a variety of pathological conditions, including inflammatory diseases. Extracellular ATP has been considered an endogenous adjuvant that can initiate inflammation by acting as a danger signal through the activation of purinergic type 2 receptors-P2 receptors (P2Y G-protein coupled receptors and P2X ligand-gated ion channels)...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29464047/a-dock-derived-compound-against-laminin-receptor-37-lr-exhibits-anti-cancer-properties-in-a-prostate-cancer-cell-line-model
#16
Charles Samuel Umbaugh, Adriana Diaz-Quiñones, Manoel Figueiredo Neto, Joseph J Shearer, Marxa L Figueiredo
Laminin receptor (67 LR) is a 67 kDa protein derived from a 37 kDa precursor (37 LR). 37/67 LR is a strong clinical correlate for progression, aggression, and chemotherapeutic relapse of several cancers including breast, prostate, and colon. The ability of 37/67 LR to promote cancer cell aggressiveness is further increased by its ability to transduce physiochemical and mechanosensing signals in endothelial cells and modulate angiogenesis. Recently, it was demonstrated that 37/67 LR modulates the anti-angiogenic potential of the secreted glycoprotein pigment epithelium-derived factor (PEDF)...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29463605/phenazines-regulate-nap-dependent-denitrification-in-pseudomonas-aeruginosa-biofilms
#17
Yu-Cheng Lin, Matthew D Sekedat, William Cole Cornell, Gustavo M Silva, Chinweike Okegbe, Alexa Price-Whelan, Christine Vogel, Lars E P Dietrich
Microbes in biofilms face the challenge of substrate limitation. In particular, cells in Pseudomonas aeruginosa biofilms growing in the laboratory or during host colonization often become limited for oxygen. Previously we found that phenazines, antibiotics produced by P. aeruginosa , balance the intracellular redox state for cells in biofilms. Here, we show that genes involved in denitrification are induced in phenazine-null (Δ phz ) mutant biofilms grown under an aerobic atmosphere, even in the absence of nitrate...
February 20, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29463254/spinacia-oleracea-extract-attenuates-disease-progression-and-sub-chondral-bone-changes-in-monosodium-iodoacetate-induced-osteoarthritis-in-rats
#18
Dharmendra Choudhary, Priyanka Kothari, Ashish Kumar Tripathi, Sonu Singh, Sulekha Adhikary, Naseer Ahmad, Sudhir Kumar, Kapil Dev, Vijay Kumar Mishra, Shubha Shukla, Rakesh Maurya, Prabhat R Mishra, Ritu Trivedi
BACKGROUND: Spinacia oleracea is an important dietary vegetable in India and throughout the world and has many beneficial effects. It is cultivated globally. However, its effect on osteoarthritis that mainly targets the cartilage cells remains unknown. In this study we aimed to evaluate the anti-osteoarthritic and chondro-protective effects of SOE on chemically induced osteoarthritis (OA). METHODS: OA was induced by intra-patellar injection of monosodium iodoacetate (MIA) at the knee joint in rats...
February 20, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29463059/glutamine-synthetase-localization-dictates-outcome
#19
REVIEW
Alessandra Castegna, Alessio Menga
Glutamine synthetase (GS) is the adenosine triphosphate (ATP)-dependent enzyme that catalyses the synthesis of glutamine by condensing ammonium to glutamate. In the circulatory system, glutamine carries ammonia from muscle and brain to the kidney and liver. In brain reduction of GS activity has been suggested as a mechanism mediating neurotoxicity in neurodegenerative disorders. In cancer, the delicate balance between glutamine synthesis and catabolism is a critical event. In vitro evidence, confirmed in vivo in some cases, suggests that reduced GS activity in cancer cells associates with a more invasive and aggressive phenotype...
February 19, 2018: Genes
https://www.readbyqxmd.com/read/29462205/spatial-analysis-of-ecosystem-service-relationships-to-improve-targeting-of-payments-for-hydrological-services
#20
Pierre Mokondoko, Robert H Manson, Taylor H Ricketts, Daniel Geissert
Payment for hydrological services (PHS) are popular tools for conserving ecosystems and their water-related services. However, improving the spatial targeting and impacts of PHS, as well as their ability to foster synergies with other ecosystem services (ES), remain challenging. We aimed at using spatial analyses to evaluate the targeting performance of México's National PHS program in central Veracruz. We quantified the effectiveness of areas targeted for PHS in actually covering areas of high HS provision and social priority during 2003-2013...
2018: PloS One
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