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https://www.readbyqxmd.com/read/29684789/bipedal-hopping-timed-to-a-metronome-to-detect-impairments-in-anticipatory-motor-control-in-people-with-mild-multiple-sclerosis
#1
Megan C Kirkland, Alice Chen, Matthew B Downer, Brett J Holloway, Elizabeth M Wallack, Evan J Lockyer, Natasha C M Buckle, Courtney L Abbott, Michelle Ploughman
BACKGROUND: People with mild multiple sclerosis (MS) often report subtle deficits in balance and cognition but display no measurable impairment on clinical assessments. We examined whether hopping to a metronome beat had the potential to detect anticipatory motor control deficits among people with mild MS (Expanded Disability Status Scale ≤ 3.5). METHODS: Participants with MS (n = 13), matched controls (n = 9), and elderly subjects (n = 13) completed tests of cognition (Montreal Cognitive Assessment (MoCA)) and motor performance (Timed 25 Foot Walk Test (T25FWT))...
April 13, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29684741/age-related-changes-in-the-range-and-velocity-of-postural-sway
#2
REVIEW
Danuta Roman-Liu
The aim of this analysis was to compare values of centre of pressure (CoP) measures, which describe the ability to maintain static body balance (range of body sway and velocity in antero-posterior and medio-lateral directions), in two age groups on the basis of a systematic review and meta-analysis of available data published worldwide. After a systematic review of publications presenting values of selected CoP measures, a numerical database with means and standard deviations was created. Data were classified by eye condition (open or closed) and by age group (18-35 or ≥56)...
April 9, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29679141/ethical-considerations-of-researchers-conducting-pediatric-clinical-drug-trials-a-qualitative-survey-in-two-belgian-university-children-s-hospitals
#3
Wannes Van Hoof, Kevin Meesters, Lien Dossche, Daphné Christiaens, Pauline De Bruyne, Johan Vande Walle
There is a general consensus about the underlying theoretical ethical principles that ground the practice of pediatric clinical trials: scientific necessity, good risk/benefit ratio, minimized burden, and parental consent/child assent. However, these principles are so broadly construed that it is not always clear how they should be applied in clinical practice. We conducted a qualitative study at Ghent University Hospital and the hospital of the Dutch-speaking university of Brussels on how researchers weigh ethical principles, assess the risk/benefit balance, estimate patient experience, and experience informed consent procedures in pediatric drug studies...
April 21, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29678738/autochthonous-lactic-acid-bacteria-isolated-from-pig-faeces-in-thailand-show-probiotic-properties-and-antibacterial-activity-against-enteric-pathogenic-bacteria
#4
Wandee Sirichokchatchawan, Puwiya Pupa, Prasert Praechansri, Nutthee Am-In, Somboon Tanasupawat, Piengchan Sonthayanon, Nuvee Prapasarakul
Lactic acid bacteria (LAB) play an important role in pig health and performance that arises from their beneficial impacts on the balance of gastrointestinal microbes, ability to fight enteric pathogens, and capacity to support the immune system. The aim of this study was to evaluate the functional and safety aspects of five previously isolated autochthonous LAB strains, (Lactobacillus plantarum 22F, 25F and 31F, Pediococcus acidilactici 72N and Pediococcus pentosaceus 77F) from pig faeces as potential probiotics for a pig feed supplement...
April 17, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29678270/multi-directional-reach-test-in-south-asian-children-normative-reference-scores-from-5-year-to-12-years-old
#5
Kavita Sharma, Asir John Samuel, Divya Midha, Vencita Priyanka Aranha, Kanimozhi Narkeesh, Narkeesh Arumugam
Multi-directional reach test (MRT) emerged as a valid and reliable assessment tool for balance evaluation among elderly. The normative reference scores have been established in adults and elderly people, but they were not yet established for children. Hence, we aimed at establishing the normative reference scores of MRT among the school going children aged between 5 and 12 years. Children (N = 194; 124 males, 70 females) were recruited by the stratified random sampling for the normative study. MRT was performed by the custom made, multi-directional reach estimator...
March 27, 2018: Homo: Internationale Zeitschrift Für die Vergleichende Forschung Am Menschen
https://www.readbyqxmd.com/read/29677664/age-induced-changes-in-the-lower-limb-muscle-activities-during-uphill-walking-at-steep-grades
#6
Sonja Th Kwee-Meier, Alexander Mertens, Sabina Jeschke
BACKGROUND: Uphill walking is particularly challenging for elderly persons. However, there is a lack of age-differentiated studies investigating the underlying differences in muscle activation when walking on sloped surfaces. These studies are needed, e.g., for planning of evacuations of large modern cruise ships with long walking distances on often inclined surfaces. METHODS: An age-differentiated, gender-balanced study with 26 young (20-30 years) and 26 elderly people (60-77 years) was therefore conducted, investigating uphill walking at 7° and at 14° contrasted to level walking on a treadmill...
April 12, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29675036/ps-fw-a-hybrid-algorithm-based-on-particle-swarm-and-fireworks-for-global-optimization
#7
Shuangqing Chen, Yang Liu, Lixin Wei, Bing Guan
Particle swarm optimization (PSO) and fireworks algorithm (FWA) are two recently developed optimization methods which have been applied in various areas due to their simplicity and efficiency. However, when being applied to high-dimensional optimization problems, PSO algorithm may be trapped in the local optima owing to the lack of powerful global exploration capability, and fireworks algorithm is difficult to converge in some cases because of its relatively low local exploitation efficiency for noncore fireworks...
2018: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/29674267/anti-inflammatory-effect-of-multistrain-probiotic-formulation-l-rhamnosus-b-lactis-and-b-longum
#8
Marzia Sichetti, Stefania De Marco, Rita Pagiotti, Giovanna Traina, Donatella Pietrella
OBJECTIVE: In recent years, a great number of studies have been directed toward the evaluation of gastrointestinal microbiota modulation through the introduction of beneficial microorganisms, also known as probiotics. Many studies have highlighted how this category of bacteria is very important for the good development, functioning, and maintenance of our immune system. There is a delicate balance between the immune system, located under the gut epithelial barrier, and the microbiota, but many factors can induce a disequilibrium that leads to an inflammatory state and dysbiosis...
February 14, 2018: Nutrition
https://www.readbyqxmd.com/read/29674190/urinary-angiotensinogen-excretion-in-australian-indigenous-and-non-indigenous-pregnant-women
#9
Kirsty G Pringle, Celine Corbisier de Meaultsart, Shane D Sykes, Loretta J Weatherall, Lyniece Keogh, Don C Clausen, Gus A Dekker, Roger Smith, Claire T Roberts, Kym M Rae, Eugenie R Lumbers
The intrarenal renin-angiotensin system (iRAS) is implicated in the pathogenesis of hypertension, chronic kidney disease and diabetic nephropathy. Urinary angiotensinogen (uAGT) levels reflect the activity of the iRAS and are altered in women with preeclampsia. Since Indigenous Australians suffer high rates and early onset of renal disease, we hypothesised that Indigenous Australian pregnant women, like non-Indigenous women with pregnancy complications, would have altered uAGT levels. The excretion of RAS proteins was measured in non-Indigenous and Indigenous Australian women with uncomplicated or complicated pregnancies (preeclampsia, diabetes/gestational diabetes, proteinuria/albuminuria, hypertension, small/large for gestational age, preterm birth), and in non-pregnant non-Indigenous women...
April 11, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29673942/allergic-patients-with-and-without-allergen-specific-immunotherapy-mount-protective-immune-responses-to-tick-borne-encephalitis-vaccination-in-absence-of-enhanced-side-effects-or-propagation-of-their-th2-bias
#10
Erika Garner-Spitzer, Claudia Seidl-Friedrich, Ines Zwazl, Michael Hofer, Tamar Kinaciyan, Reinhart Jarisch, Karin Stiasny, Gerhard J Zlabinger, Michael Kundi, Ursula Wiedermann
BACKGROUND: Allergic diseases are caused by Th2-driven immune responses and their treatment with specific immunotherapy (SIT) leads to immunomodulation via IL10, TGF-ß and Th1/Tr1 shift. This phase IV, open-label clinical trial investigated whether allergies and SIT treatment influenced immune responses to routine vaccination. METHODS: We studied three groups: 49 allergic patients (allergic group), 21 allergic patients receiving maintenance doses of SIT (SIT group), and 49 non-allergic controls...
April 16, 2018: Vaccine
https://www.readbyqxmd.com/read/29673717/novel-fatty-acid-chain-modified-glp-1-derivatives-with-prolonged-in-vivo-glucose-lowering-ability-and-balanced-glucoregulatory-activity
#11
Xingguang Cai, Lidan Sun, Yuxuan Dai, Yosefa Avraham, Chunxia Liu, Jing Han, Yuan Liu, Dazhi Feng, Wenlong Huang, Hai Qian
Glucagon-like peptide-1 is a potent hypoglycemic hormone with beneficial properties for the treatment of diabetes. However, its half-life is short because the rapid metabolic degradation. This study aims to prolong the half-life of glucagon-like peptide-1 through conjugation with the fatty acid side chain which helps the conjugates to interact with the albumin. Firstly, we chose two optimized polypeptide chains which have tremendous hypoglycemic effect named Cys17 -Gly8 -GLP-1(7-36)-NH2 and Cys37 -Gly8 -GLP-1(7-37)-NH2 , and various fatty acid chains were modified...
April 11, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29673051/strategies-of-leaf-water-uptake-based-on-anatomical-traits
#12
Daniela Boanares, Rosy Mary Dos Santos Isaias, Hildeberto Caldas de Sousa, Alessandra Rodrigues Kozovits
- The ability of leaves to absorb fog water can positively contribute to the water and carbon balance of plants in montane ecosystems, especially in periods of soil water deficit. However, the ecophysiological traits and mechanisms responsible for variations in the speed and total water absorption capacity of leaves are still poorly known. - This study investigated leaf anatomical attributes of seven species occurring in seasonal tropical high-altitude ecosystems (rocky outcrop and forest), which could explain differences in leaf water uptake (LWU) capacities...
April 19, 2018: Plant Biology
https://www.readbyqxmd.com/read/29673013/postural-control-during-a-transition-task-in-haemophilic-children-adolescents-and-young-adults-with-haemophilic-ankle-arthropathy
#13
K Deschamps, F Staes, M Eerdekens, K Peerlinck, C Hermans, J Vandesande, S Lobet
BACKGROUND: The aim of this study was to determine whether young haemophilic boys with and without MRI-based signs of ankle arthropathy demonstrate reduced balance ability during a transition task with eyes open and eyes closed. METHODS: Thirty-four haemophilic bodies and 28 typically developing boys aged 6-20 years participated to this study. Structural integrity of the tarsal foot joints of all haemophilic boys was assessed with MRI. All participants performed a standard transition task from double-leg stance to single-leg stance with eyes open and eyes closed...
April 19, 2018: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/29671393/predicting-and-understanding-comprehensive-drug-drug-interactions-via-semi-nonnegative-matrix-factorization
#14
Hui Yu, Kui-Tao Mao, Jian-Yu Shi, Hua Huang, Zhi Chen, Kai Dong, Siu-Ming Yiu
BACKGROUND: Drug-drug interactions (DDIs) always cause unexpected and even adverse drug reactions. It is important to identify DDIs before drugs are used in the market. However, preclinical identification of DDIs requires much money and time. Computational approaches have exhibited their abilities to predict potential DDIs on a large scale by utilizing pre-market drug properties (e.g. chemical structure). Nevertheless, none of them can predict two comprehensive types of DDIs, including enhancive and degressive DDIs, which increases and decreases the behaviors of the interacting drugs respectively...
April 11, 2018: BMC Systems Biology
https://www.readbyqxmd.com/read/29670495/impact-of-pilates-exercise-in-multiple-sclerosis-a-randomized-controlled-trial
#15
Whitney R D Duff, Justin W Andrushko, Doug W Renshaw, Philip D Chilibeck, Jonathan P Farthing, Jana Danielson, Charity D Evans
Background: Pilates is a series of exercises based on whole-body movement and may improve mobility in people with multiple sclerosis (MS). The purpose of this study was to determine the effect of Pilates on walking performance in people with MS. Methods: 30 individuals with MS who were not restricted to a wheelchair or scooter (Patient-Determined Disease Steps scale score <7) were randomized to receive Pilates (twice weekly) and massage therapy (once weekly) or once-weekly massage therapy only (control group)...
March 2018: International Journal of MS Care
https://www.readbyqxmd.com/read/29670343/effect-of-6-month-community-based-exercise-interventions-on-gait-and-functional-fitness-of-an-older-population-a-quasi-experimental-study
#16
Fátima Ramalho, Rita Santos-Rocha, Marco Branco, Vera Moniz-Pereira, Helô-Isa André, António P Veloso, Filomena Carnide
Background: Gait ability in older adults has been associated with independent living, increased survival rates, fall prevention, and quality of life. There are inconsistent findings regarding the effects of exercise interventions in the maintenance of gait parameters. Objectives: The aim of the study was to analyze the effects of a community-based periodized exercise intervention on the improvement of gait parameters and functional fitness in an older adult group compared with a non-periodized program...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29670114/entrainment-of-theta-not-alpha-oscillations-is-predictive-of-the-brightness-enhancement-of-a-flickering-stimulus
#17
Jennifer K Bertrand, Nathan J Wispinski, Kyle E Mathewson, Craig S Chapman
Frequency-dependent brightness enhancement, where a flickering light can appear twice as bright as an equiluminant constant light, has been reported to exist within the alpha (8-12 Hz) band. Could oscillatory neural activity be driving this perceptual effect? Here, in two experiments, human subjects reported which of two flickering stimuli were brighter. Strikingly, 4 Hz stimuli were reported as brighter more than 80% of the time when compared to all other tested frequencies, even though all stimuli were equiluminant and of equal temporal length...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29669499/qsar-study-of-some-1-3-oxazolylphosphonium-derivatives-as-new-potent-anti-candida-agents-and-their-toxicity-evaluation
#18
Maria M Trush, Vasyl Kovalishyn, Alla D Ocheretniuk, Oleksandr L Kobzar, Maryna V Kachaeva, Volodymyr S Brovarets, Larisa O Metelytsia
This paper describes QSAR studies by using the Online Chemical Modeling Environment, synthesis, in vitro antifungal activity of 1,3-oxazolylphosphonium derivatives and their acetylcholinesterase inhibitory potential. Three classification QSAR models were created using Random Forests (WEKA-RF), k-Nearest Neighbors and Associative Neural Networks methods and different combinations of descriptors. The predictive ability of the models was tested through cross-validation, giving a balanced accuracy BA=80-91%. All compounds demonstrated good antifungal properties and slight inhibition of acetylcholinesterase activity...
April 18, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29668363/a-data-entrained-computational-model-for-testing-the-regulatory-logic-of-the-vertebrate-unfolded-protein-response
#19
Danilo R Diedrichs, Javier A Gomez, Chun-Sing Huang, D Thomas Rutkowski, Rodica Curtu
The vertebrate unfolded protein response (UPR) is characterized by multiple interacting nodes among its three pathways, yet the logic underlying this regulatory complexity is unclear. To begin to address this issue, we created a computational model of the vertebrate UPR that was entrained upon and then validated against experimental data. As part of this validation, the model successfully predicted the phenotypes of cells with lesions in UPR signaling, including a surprising and previously unreported differential role for the eIF2α phosphatase GADD34 in exacerbating severe stress but ameliorating mild stress...
April 18, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29668284/the-double-edged-effect-of-hydroxychloroquine-on-human-umbilical-cord-derived-mesenchymal-stem-cells-treating-lupus-nephritis-in-mrl-lpr-mice
#20
Shaoshan Mai, Lin Zou, Xiaoyan Tian, Xiao Liao, Yizhao Luan, Xing Han, Yuling Wei, Yue Wu, Shengnan Kuang, Yang Yang, Jie Ma, Qi Chen, Junqing Yang
Hydroxychlorquine(HCQ) and human umbilical cord-derived mesenchymal stem cells (UC-MSCs) were used to treat systemic lupus erythematosus(SLE),respectively. However, the effect of HCQ on UC-MSCs in lupus nephritis (LN) has not been investigated. In this study, HCQ and UC-MSCs were used in MRL/lpr mice. Surprisingly, although the treatment of both HCQ and UC-MSCs could ameliorate renal damage separately, the presence of HCQ decreased unexpectedly the therapeutic effects of UC-MSCs through interfering expression of IFN-γ...
April 18, 2018: Molecular Pharmaceutics
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