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Lesley Anderson

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https://www.readbyqxmd.com/read/28885714/monoclonal-gammopathy-of-undetermined-significance-mgus-as-viewed-by-haematology-healthcare-professionals
#1
Charlene M McShane, Blain Murphy, Kah Heng Lim, Lesley A Anderson
OBJECTIVES: To investigate the words and descriptions used by haematology healthcare professionals (HCPs) to describe monoclonal gammopathy of undetermined significance (MGUS) to their patients. METHODS: A cross-sectional survey of haematology HCPs attending an annual haematology conference was undertaken. Content analysis was applied to the returned qualitative responses. RESULTS: In total, 55 people, many of whom were doctors (n=32; 58.2%) responded...
September 8, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28827277/an-investigation-of-the-predictors-of-photoprotection-and-uvr-dose-to-the-face-in-patients-with-xp-a-protocol-using-observational-mixed-methods
#2
Jessica Walburn, Robert Sarkany, Sam Norton, Lesley Foster, Myfanwy Morgan, Kirby Sainsbury, Vera Araújo-Soares, Rebecca Anderson, Isabel Garrood, Jakob Heydenreich, Falko F Sniehotta, Rute Vieira, Hans Christian Wulf, John Weinman
INTRODUCTION: Xeroderma pigmentosum (XP) is a rare genetic condition caused by defective nucleotide excision repair and characterised by skin cancer, ocular and neurological involvement. Stringent ultraviolet protection is the only way to prevent skin cancer. Despite the risks, some patients' photoprotection is poor, with a potentially devastating impact on their prognosis. The aim of this research is to identify disease-specific and psychosocial predictors of photoprotection behaviour and ultraviolet radiation (UVR) dose to the face...
August 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28751756/knowledge-or-noise-making-sense-of-general-practitioners-and-consultant-use-of-2-week-wait-referrals-for-suspected-cancer
#3
Conan Donnelly, Nigel Hart, Alan David McCrorie, Lesley Anderson, Michael Donnelly, Peter Murchie, Anna Gavin
BACKGROUND: Early diagnosis and treatment of cancer is the goal of the 2-week-wait referral pathway (2WW). Variation exists between General Practice use of 2WW and rates of consultant reprioritisation of GP referral from routine to 2WW (Consultant Upgrade). We investigated variation in General Practice and Consultant Upgrade 2WW referral activity. METHODS: Data from 185 000 referrals and 29 000 cancers recorded between 2011 and 2013 from the Northern Ireland Cancer Waiting Time database (CaPPS) were analysed to ascertain standardised referral rate ratios, detection rate (DR) (=sensitivity) and conversion rate (CR) (=positive predictive value) for Practice 2WW referrals and Consultant Upgrade 2WW...
August 22, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28687376/burden-and-centralised-treatment-in-europe-of-rare-tumours-results-of-rarecarenet-a-population-based-study
#4
Gemma Gatta, Riccardo Capocaccia, Laura Botta, Sandra Mallone, Roberta De Angelis, Eva Ardanaz, Harry Comber, Nadya Dimitrova, Maarit K Leinonen, Sabine Siesling, Jan M van der Zwan, Liesbet Van Eycken, Otto Visser, Maja P Žakelj, Lesley A Anderson, Francesca Bella, Innos Kaire, Renée Otter, Charles A Stiller, Annalisa Trama
BACKGROUND: Rare cancers pose challenges for diagnosis, treatments, and clinical decision making. Information about rare cancers is scant. The RARECARE project defined rare cancers as those with an annual incidence of less than six per 100 000 people in European Union (EU). We updated the estimates of the burden of rare cancers in Europe, their time trends in incidence and survival, and provide information about centralisation of treatments in seven European countries. METHODS: We analysed data from 94 cancer registries for more than 2 million rare cancer diagnoses, to estimate European incidence and survival in 2000-07 and the corresponding time trends during 1995-2007...
August 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28571591/dietary-inflammatory-index-and-risk-of-reflux-oesophagitis-barrett-s-oesophagus-and-oesophageal-adenocarcinoma-a-population-based-case-control-study
#5
Nitin Shivappa, James R Hebert, Lesley A Anderson, Martha J Shrubsole, Liam J Murray, Lauren B Getty, Helen G Coleman
The dietary inflammatory index (DIITM) is a novel composite score based on a range of nutrients and foods known to be associated with inflammation. DII scores have been linked to the risk of a number of cancers, including oesophageal squamous cell cancer and oesophageal adenocarcinoma (OAC). Given that OAC stems from acid reflux and that the oesophageal epithelium undergoes a metaplasia-dysplasia transition from the resulting inflammation, it is plausible that a high DII score (indicating a pro-inflammatory diet) may exacerbate risk of OAC and its precursor conditions...
May 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28424302/assessing-the-safety-culture-of-care-homes-a-multimethod-evaluation-of-the-adaptation-face-validity-and-feasibility-of-the-manchester-patient-safety-framework
#6
Martin Marshall, Lesley Cruickshank, Jenny Shand, Sarah Perry, James Anderson, Li Wei, Dianne Parker, Debra de Silva
BACKGROUND: Understanding the cultural characteristics of healthcare organisations is widely recognised to be an important component of patient safety. A growing number of vulnerable older people are living in care homes but little attention has been paid to safety culture in this sector. In this study, we aimed to adapt the Manchester Patient Safety Framework (MaPSaF), a commonly used tool in the health sector, for use in care homes and then to test its face validity and preliminary feasibility as a tool for developing a better understanding of safety culture in the sector...
April 19, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28300685/external-validation-of-the-michigan-barrett-s-esophagus-prediction-tool
#7
Aaron P Thrift, Thomas L Vaughan, Lesley A Anderson, David C Whiteman, Hashem B El-Serag
No abstract text is available yet for this article.
July 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28252462/the-prevalence-of-viral-agents-in-esophageal-adenocarcinoma-and-barrett-s-esophagus-a-systematic-review
#8
Andrew T Kunzmann, Suzanne Graham, Charlene M McShane, James Doyle, Massimo Tommasino, Brian Johnston, Jackie Jamison, Jacqueline A James, Damian McManus, Lesley A Anderson
BACKGROUND AND AIMS: Human papilloma virus (HPV), which may reach the esophagus through orogenital transmission, has been postulated to be associated with esophageal adenocarcinoma (EAC). A systematic review of the literature investigating the prevalence of infectious agents in EAC and Barrett's esophagus (BE) was carried out. METHODS: Using terms for viruses and EAC, the Medline, Embase, and Web of Science databases were systematically searched for studies published, in any language, until June 2016 that assessed the prevalence of viral agents in EAC or BE...
July 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28160468/consensus-best-practice-pathway-of-the-uk-systemic-sclerosis-study-group-management-of-cardiac-disease-in-systemic-sclerosis
#9
Lesley-Anne Bissell, Marina Anderson, Malcolm Burgess, Kuntal Chakravarty, Gerry Coghlan, Raluca B Dumitru, Lee Graham, Voon Ong, John D Pauling, Sven Plein, Dominik Schlosshan, Peter Woolfson, Maya H Buch
Objective.: Cardiac disease in SSc can manifest in various ways and is associated with a poor prognosis. There is little evidence on how best to detect and manage cardiac disease in SSc. Our objective was to produce an expert consensus best practice pathway for the management of cardiac disease in SSc. Methods.: The UK Systemic Sclerosis Study Group set up several working groups to develop a number of consensus best practice pathways for the management of SSc-specific complications, including cardiac disease...
June 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28146334/dementia-and-co-occurring-chronic-conditions-a-systematic-literature-review-to-identify-what-is-known-and-where-are-the-gaps-in-the-evidence
#10
REVIEW
Mark B Snowden, Lesley E Steinman, Lucinda L Bryant, Monique M Cherrier, Kurt J Greenlund, Katherine H Leith, Cari Levy, Rebecca G Logsdon, Catherine Copeland, Mia Vogel, Lynda A Anderson, David C Atkins, Janice F Bell, Annette L Fitzpatrick
OBJECTIVE: The challenges posed by people living with multiple chronic conditions are unique for people with dementia and other significant cognitive impairment. There have been recent calls to action to review the existing literature on co-occurring chronic conditions and dementia in order to better understand the effect of cognitive impairment on disease management, mobility, and mortality. METHODS: This systematic literature review searched PubMed databases through 2011 (updated in 2016) using key constructs of older adults, moderate-to-severe cognitive impairment (both diagnosed and undiagnosed dementia), and chronic conditions...
April 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28031315/pooled-analysis-of-active-cigarette-smoking-and-invasive-breast-cancer-risk-in-14-cohort-studies
#11
Mia M Gaudet, Brian D Carter, Louise A Brinton, Roni T Falk, Inger T Gram, Juhua Luo, Roger L Milne, Sarah J Nyante, Elisabete Weiderpass, Laura E Beane Freeman, Dale P Sandler, Kim Robien, Kristin E Anderson, Graham G Giles, Wendy Y Chen, Diane Feskanich, Tonje Braaten, Claudine Isaacs, Lesley M Butler, Woon-Puay Koh, Alicja Wolk, Hans-Olov Adami, Emily White, Karen L Margolis, Michael J Thun, Susan M Gapstur
BACKGROUND: The 2014 US Surgeon General's report noted research gaps necessary to determine a causal relationship between active cigarette smoking and invasive breast cancer risk, including the role of alcohol consumption, timing of exposure, modification by menopausal status and heterogeneity by oestrogen receptor (ER) status. METHODS: To address these issues, we pooled data from 14 cohort studies contributing 934 681 participants (36 060 invasive breast cancer cases)...
December 28, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27986901/what-we-know-about-designing-an-effective-improvement-intervention-but-too-often-fail-to-put-into-practice
#12
Martin Marshall, Debra de Silva, Lesley Cruickshank, Jenny Shand, Li Wei, James Anderson
No abstract text is available yet for this article.
July 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/27791177/towards-a-transcriptome-based-theranostic-platform-for-unfavorable-breast-cancer-phenotypes
#13
Andrey S Dobroff, Sara D'Angelo, Bedrich L Eckhardt, Fortunato Ferrara, Daniela I Staquicini, Marina Cardó-Vila, Fernanda I Staquicini, Diana N Nunes, Kisu Kim, Wouter H P Driessen, Amin Hajitou, Lesley C Lomo, Marc Barry, Savitri Krishnamurthy, Aysegul Sahin, Wendy A Woodward, Eric R Prossnitz, Robin L Anderson, Emmanuel Dias-Neto, Ursa A Brown-Glaberman, Melanie E Royce, Naoto T Ueno, Massimo Cristofanilli, Gabriel N Hortobagyi, Serena Marchiò, Juri G Gelovani, Richard L Sidman, Wadih Arap, Renata Pasqualini
Inflammatory breast carcinoma (IBC) is one of the most lethal forms of human breast cancer, and effective treatment for IBC is an unmet clinical need in contemporary oncology. Tumor-targeted theranostic approaches are emerging in precision medicine, but only a few specific biomarkers are available. Here we report up-regulation of the 78-kDa glucose-regulated protein (GRP78) in two independent discovery and validation sets of specimens derived from IBC patients, suggesting translational promise for clinical applications...
October 24, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27779354/pharmacokinetics-and-analgesic-effectiveness-of-intravenous-parecoxib-for-tonsillectomy-%C3%A2-adenoidectomy
#14
RANDOMIZED CONTROLLED TRIAL
Lena Tan, Elsa Taylor, Jacqueline A Hannam, Lesley Salkeld, Sam Salman, Brian J Anderson
BACKGROUND: Few pharmacokinetic (PK) and pharmacodynamic (PD) data exist for COX-2 selective inhibitors in children. We wished to characterize the PKPD of parecoxib and its active metabolite, valdecoxib, in this population. METHODS: Children (n = 59) were randomized to parecoxib 0.25 mg·kg(-1) , 1 mg·kg(-1) , and 2 mg·kg(-1) during tonsillectomy ± adenoidectomy. Samples (4-6 per child) were obtained from indwelling cannula over 6 h. A second group of inpatient children (n = 15) given 1 mg·kg(-1) contributed PK data from 6 to 24 h...
December 2016: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/27663042/non-gfr-determinants-of-low-molecular-weight-serum-protein%C3%A2-filtration-markers-in-ckd
#15
Xun Liu, Meredith C Foster, Hocine Tighiouart, Amanda H Anderson, Gerald J Beck, Gabriel Contreras, Josef Coresh, John H Eckfeldt, Harold I Feldman, Tom Greene, L Lee Hamm, Jiang He, Edward Horwitz, Julia Lewis, Ana C Ricardo, Haochang Shou, Raymond R Townsend, Matthew R Weir, Lesley A Inker, Andrew S Levey
BACKGROUND: Unlike the case with creatinine, conditions affecting the non-glomerular filtration rate (GFR) determinants of low-molecular-weight serum proteins, β-trace protein (BTP), β2-microglobulin (B2M), and cystatin C, are not well characterized. STUDY DESIGN: Pooled cross-sectional analysis of 3 studies. SETTING & PARTICIPANTS: 3,156 persons with chronic kidney disease from the MDRD (Modification of Diet in Renal Disease) Study, AASK (African American Study of Kidney Disease and Hypertension), and CRIC (Chronic Renal Insufficiency Cohort) Study...
December 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27575711/nonsteroidal-anti-inflammatory-drug-use-is-not-associated-with-reduced-risk-of-barrett-s-esophagus
#16
Aaron P Thrift, Lesley A Anderson, Liam J Murray, Michael B Cook, Nicholas J Shaheen, Joel H Rubenstein, Hashem B El-Serag, Thomas L Vaughan, Jennifer L Schneider, David C Whiteman, Douglas A Corley
OBJECTIVES: Regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced risk of esophageal adenocarcinoma. Epidemiological studies examining the association between NSAID use and the risk of the precursor lesion, Barrett's esophagus, have been inconclusive. METHODS: We analyzed pooled individual-level participant data from six case-control studies of Barrett's esophagus in the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON)...
November 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27539503/pok%C3%A3-mon-go-mobile-app-user-guides
#17
Nash Anderson, James Steele, Lise-Ann O'Neill, Lesley A Harden
No abstract text is available yet for this article.
August 18, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27527254/genome-wide-association-studies-in-oesophageal-adenocarcinoma-and-barrett-s-oesophagus-a-large-scale-meta-analysis
#18
Puya Gharahkhani, Rebecca C Fitzgerald, Thomas L Vaughan, Claire Palles, Ines Gockel, Ian Tomlinson, Matthew F Buas, Andrea May, Christian Gerges, Mario Anders, Jessica Becker, Nicole Kreuser, Tania Noder, Marino Venerito, Lothar Veits, Thomas Schmidt, Hendrik Manner, Claudia Schmidt, Timo Hess, Anne C Böhmer, Jakob R Izbicki, Arnulf H Hölscher, Hauke Lang, Dietmar Lorenz, Brigitte Schumacher, Andreas Hackelsberger, Rupert Mayershofer, Oliver Pech, Yogesh Vashist, Katja Ott, Michael Vieth, Josef Weismüller, Markus M Nöthen, Stephen Attwood, Hugh Barr, Laura Chegwidden, John de Caestecker, Rebecca Harrison, Sharon B Love, David MacDonald, Paul Moayyedi, Hans Prenen, R G Peter Watson, Prasad G Iyer, Lesley A Anderson, Leslie Bernstein, Wong-Ho Chow, Laura J Hardie, Jesper Lagergren, Geoffrey Liu, Harvey A Risch, Anna H Wu, Weimin Ye, Nigel C Bird, Nicholas J Shaheen, Marilie D Gammon, Douglas A Corley, Carlos Caldas, Susanne Moebus, Michael Knapp, Wilbert H M Peters, Horst Neuhaus, Thomas Rösch, Christian Ell, Stuart MacGregor, Paul Pharoah, David C Whiteman, Janusz Jankowski, Johannes Schumacher
BACKGROUND: Oesophageal adenocarcinoma represents one of the fastest rising cancers in high-income countries. Barrett's oesophagus is the premalignant precursor of oesophageal adenocarcinoma. However, only a few patients with Barrett's oesophagus develop adenocarcinoma, which complicates clinical management in the absence of valid predictors. Within an international consortium investigating the genetics of Barrett's oesophagus and oesophageal adenocarcinoma, we aimed to identify novel genetic risk variants for the development of Barrett's oesophagus and oesophageal adenocarcinoma...
October 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27322014/dynamic-surfaces-for-the-study-of-mesenchymal-stem-cell-growth-through-adhesion-regulation
#19
Jemma N Roberts, Jugal Kishore Sahoo, Laura E McNamara, Karl V Burgess, Jingli Yang, Enateri V Alakpa, Hilary J Anderson, Jake Hay, Lesley-Anne Turner, Stephen J Yarwood, Mischa Zelzer, Richard O C Oreffo, Rein V Ulijn, Matthew J Dalby
Out of their niche environment, adult stem cells, such as mesenchymal stem cells (MSCs), spontaneously differentiate. This makes both studying these important regenerative cells and growing large numbers of stem cells for clinical use challenging. Traditional cell culture techniques have fallen short of meeting this challenge, but materials science offers hope. In this study, we have used emerging rules of managing adhesion/cytoskeletal balance to prolong MSC cultures by fabricating controllable nanoscale cell interfaces using immobilized peptides that may be enzymatically activated to change their function...
July 26, 2016: ACS Nano
https://www.readbyqxmd.com/read/27265454/pneumococcal-vaccine-impact-on-otitis-media-microbiology-a-new-zealand-cohort-study-before-and-after-the-introduction-of-phid-cv10-vaccine
#20
Emma J Best, Tony Walls, Melanie Souter, Michel Neeff, Trevor Anderson, Lesley Salkeld, Zahoor Ahmad, Murali Mahadevan, Cameron Walker, David Murdoch, Nikki Mills
UNLABELLED: We compared the microbiology of middle ear fluid (MEF) in two cohorts of children having ventilation tube (VT) insertion; the first in the era of 7-valent Streptococcus pneumoniae conjugate vaccine (PCV7) and the second following introduction of the ten-valent pneumococcal vaccine (PHiD-CV10). METHODS: During 2011 (Phase 1) and again in 2014 (Phase 2) MEF and NP samples from 325 children and 319 children were taken at the time of VT insertion. A matched comparison group had NP swabs collected with 137 children (Phase 1) and 154 (Phase 2)...
July 19, 2016: Vaccine
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