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Lesley Anderson

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https://www.readbyqxmd.com/read/28424302/assessing-the-safety-culture-of-care-homes-a-multimethod-evaluation-of-the-adaptation-face-validity-and-feasibility-of-the-manchester-patient-safety-framework
#1
Martin Marshall, Lesley Cruickshank, Jenny Shand, Sarah Perry, James Anderson, Li Wei, Dianne Parker, Debra de Silva
BACKGROUND: Understanding the cultural characteristics of healthcare organisations is widely recognised to be an important component of patient safety. A growing number of vulnerable older people are living in care homes but little attention has been paid to safety culture in this sector. In this study, we aimed to adapt the Manchester Patient Safety Framework (MaPSaF), a commonly used tool in the health sector, for use in care homes and then to test its face validity and preliminary feasibility as a tool for developing a better understanding of safety culture in the sector...
April 19, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28300685/external-validation-of-the-michigan-barrett-s-esophagus-prediction-tool
#2
Aaron P Thrift, Thomas L Vaughan, Lesley A Anderson, David C Whiteman, Hashem B El-Serag
No abstract text is available yet for this article.
March 11, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28252462/the-prevalence-of-viral-agents-in-esophageal-adenocarcinoma-and-barrett-s-esophagus-a-systematic-review
#3
Andrew T Kunzmann, Suzanne Graham, Charlene M McShane, James Doyle, Massimo Tommasino, Brian Johnston, Jackie Jamison, Jacqueline A James, Damian McManus, Lesley A Anderson
BACKGROUND AND AIMS: Human papilloma virus (HPV), which may reach the esophagus through orogenital transmission, has been postulated to be associated with esophageal adenocarcinoma (EAC). A systematic review of the literature investigating the prevalence of infectious agents in EAC and Barrett's esophagus (BE) was carried out. METHODS: Using terms for viruses and EAC, the Medline, Embase, and Web of Science databases were systematically searched for studies published, in any language, until June 2016 that assessed the prevalence of viral agents in EAC or BE...
March 1, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28160468/consensus-best-practice-pathway-of-the-uk-systemic-sclerosis-study-group-management-of-cardiac-disease-in-systemic-sclerosis
#4
Lesley-Anne Bissell, Marina Anderson, Malcolm Burgess, Kuntal Chakravarty, Gerry Coghlan, Raluca B Dumitru, Lee Graham, Voon Ong, John D Pauling, Sven Plein, Dominik Schlosshan, Peter Woolfson, Maya H Buch
No abstract text is available yet for this article.
February 4, 2017: Rheumatology
https://www.readbyqxmd.com/read/28146334/dementia-and-co-occurring-chronic-conditions-a-systematic-literature-review-to-identify-what-is-known-and-where-are-the-gaps-in-the-evidence
#5
REVIEW
Mark B Snowden, Lesley E Steinman, Lucinda L Bryant, Monique M Cherrier, Kurt J Greenlund, Katherine H Leith, Cari Levy, Rebecca G Logsdon, Catherine Copeland, Mia Vogel, Lynda A Anderson, David C Atkins, Janice F Bell, Annette L Fitzpatrick
OBJECTIVE: The challenges posed by people living with multiple chronic conditions are unique for people with dementia and other significant cognitive impairment. There have been recent calls to action to review the existing literature on co-occurring chronic conditions and dementia in order to better understand the effect of cognitive impairment on disease management, mobility, and mortality. METHODS: This systematic literature review searched PubMed databases through 2011 (updated in 2016) using key constructs of older adults, moderate-to-severe cognitive impairment (both diagnosed and undiagnosed dementia), and chronic conditions...
February 1, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28031315/pooled-analysis-of-active-cigarette-smoking-and-invasive-breast-cancer-risk-in-14-cohort-studies
#6
Mia M Gaudet, Brian D Carter, Louise A Brinton, Roni T Falk, Inger T Gram, Juhua Luo, Roger L Milne, Sarah J Nyante, Elisabete Weiderpass, Laura E Beane Freeman, Dale P Sandler, Kim Robien, Kristin E Anderson, Graham G Giles, Wendy Y Chen, Diane Feskanich, Tonje Braaten, Claudine Isaacs, Lesley M Butler, Woon-Puay Koh, Alicja Wolk, Hans-Olov Adami, Emily White, Karen L Margolis, Michael J Thun, Susan M Gapstur
BACKGROUND: The 2014 US Surgeon General's report noted research gaps necessary to determine a causal relationship between active cigarette smoking and invasive breast cancer risk, including the role of alcohol consumption, timing of exposure, modification by menopausal status and heterogeneity by oestrogen receptor (ER) status. METHODS: To address these issues, we pooled data from 14 cohort studies contributing 934 681 participants (36 060 invasive breast cancer cases)...
December 28, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27986901/what-we-know-about-designing-an-effective-improvement-intervention-but-too-often-fail-to-put-into-practice
#7
Martin Marshall, Debra de Silva, Lesley Cruickshank, Jenny Shand, Li Wei, James Anderson
No abstract text is available yet for this article.
December 16, 2016: BMJ Quality & Safety
https://www.readbyqxmd.com/read/27791177/towards-a-transcriptome-based-theranostic-platform-for-unfavorable-breast-cancer-phenotypes
#8
Andrey S Dobroff, Sara D'Angelo, Bedrich L Eckhardt, Fortunato Ferrara, Daniela I Staquicini, Marina Cardó-Vila, Fernanda I Staquicini, Diana N Nunes, Kisu Kim, Wouter H P Driessen, Amin Hajitou, Lesley C Lomo, Marc Barry, Savitri Krishnamurthy, Aysegul Sahin, Wendy A Woodward, Eric R Prossnitz, Robin L Anderson, Emmanuel Dias-Neto, Ursa A Brown-Glaberman, Melanie E Royce, Naoto T Ueno, Massimo Cristofanilli, Gabriel N Hortobagyi, Serena Marchiò, Juri G Gelovani, Richard L Sidman, Wadih Arap, Renata Pasqualini
Inflammatory breast carcinoma (IBC) is one of the most lethal forms of human breast cancer, and effective treatment for IBC is an unmet clinical need in contemporary oncology. Tumor-targeted theranostic approaches are emerging in precision medicine, but only a few specific biomarkers are available. Here we report up-regulation of the 78-kDa glucose-regulated protein (GRP78) in two independent discovery and validation sets of specimens derived from IBC patients, suggesting translational promise for clinical applications...
October 24, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27779354/pharmacokinetics-and-analgesic-effectiveness-of-intravenous-parecoxib-for-tonsillectomy-%C3%A2-adenoidectomy
#9
Lena Tan, Elsa Taylor, Jacqueline A Hannam, Lesley Salkeld, Sam Salman, Brian J Anderson
BACKGROUND: Few pharmacokinetic (PK) and pharmacodynamic (PD) data exist for COX-2 selective inhibitors in children. We wished to characterize the PKPD of parecoxib and its active metabolite, valdecoxib, in this population. METHODS: Children (n = 59) were randomized to parecoxib 0.25 mg·kg(-1) , 1 mg·kg(-1) , and 2 mg·kg(-1) during tonsillectomy ± adenoidectomy. Samples (4-6 per child) were obtained from indwelling cannula over 6 h. A second group of inpatient children (n = 15) given 1 mg·kg(-1) contributed PK data from 6 to 24 h...
December 2016: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/27663042/non-gfr-determinants-of-low-molecular-weight-serum-protein%C3%A2-filtration-markers-in-ckd
#10
Xun Liu, Meredith C Foster, Hocine Tighiouart, Amanda H Anderson, Gerald J Beck, Gabriel Contreras, Josef Coresh, John H Eckfeldt, Harold I Feldman, Tom Greene, L Lee Hamm, Jiang He, Edward Horwitz, Julia Lewis, Ana C Ricardo, Haochang Shou, Raymond R Townsend, Matthew R Weir, Lesley A Inker, Andrew S Levey
BACKGROUND: Unlike the case with creatinine, conditions affecting the non-glomerular filtration rate (GFR) determinants of low-molecular-weight serum proteins, β-trace protein (BTP), β2-microglobulin (B2M), and cystatin C, are not well characterized. STUDY DESIGN: Pooled cross-sectional analysis of 3 studies. SETTING & PARTICIPANTS: 3,156 persons with chronic kidney disease from the MDRD (Modification of Diet in Renal Disease) Study, AASK (African American Study of Kidney Disease and Hypertension), and CRIC (Chronic Renal Insufficiency Cohort) Study...
December 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27575711/nonsteroidal-anti-inflammatory-drug-use-is-not-associated-with-reduced-risk-of-barrett-s-esophagus
#11
Aaron P Thrift, Lesley A Anderson, Liam J Murray, Michael B Cook, Nicholas J Shaheen, Joel H Rubenstein, Hashem B El-Serag, Thomas L Vaughan, Jennifer L Schneider, David C Whiteman, Douglas A Corley
OBJECTIVES: Regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced risk of esophageal adenocarcinoma. Epidemiological studies examining the association between NSAID use and the risk of the precursor lesion, Barrett's esophagus, have been inconclusive. METHODS: We analyzed pooled individual-level participant data from six case-control studies of Barrett's esophagus in the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON)...
November 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27539503/pok%C3%A3-mon-go-mobile-app-user-guides
#12
Nash Anderson, James Steele, Lise-Ann O'Neill, Lesley A Harden
No abstract text is available yet for this article.
August 18, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27527254/genome-wide-association-studies-in-oesophageal-adenocarcinoma-and-barrett-s-oesophagus-a-large-scale-meta-analysis
#13
Puya Gharahkhani, Rebecca C Fitzgerald, Thomas L Vaughan, Claire Palles, Ines Gockel, Ian Tomlinson, Matthew F Buas, Andrea May, Christian Gerges, Mario Anders, Jessica Becker, Nicole Kreuser, Tania Noder, Marino Venerito, Lothar Veits, Thomas Schmidt, Hendrik Manner, Claudia Schmidt, Timo Hess, Anne C Böhmer, Jakob R Izbicki, Arnulf H Hölscher, Hauke Lang, Dietmar Lorenz, Brigitte Schumacher, Andreas Hackelsberger, Rupert Mayershofer, Oliver Pech, Yogesh Vashist, Katja Ott, Michael Vieth, Josef Weismüller, Markus M Nöthen, Stephen Attwood, Hugh Barr, Laura Chegwidden, John de Caestecker, Rebecca Harrison, Sharon B Love, David MacDonald, Paul Moayyedi, Hans Prenen, R G Peter Watson, Prasad G Iyer, Lesley A Anderson, Leslie Bernstein, Wong-Ho Chow, Laura J Hardie, Jesper Lagergren, Geoffrey Liu, Harvey A Risch, Anna H Wu, Weimin Ye, Nigel C Bird, Nicholas J Shaheen, Marilie D Gammon, Douglas A Corley, Carlos Caldas, Susanne Moebus, Michael Knapp, Wilbert H M Peters, Horst Neuhaus, Thomas Rösch, Christian Ell, Stuart MacGregor, Paul Pharoah, David C Whiteman, Janusz Jankowski, Johannes Schumacher
BACKGROUND: Oesophageal adenocarcinoma represents one of the fastest rising cancers in high-income countries. Barrett's oesophagus is the premalignant precursor of oesophageal adenocarcinoma. However, only a few patients with Barrett's oesophagus develop adenocarcinoma, which complicates clinical management in the absence of valid predictors. Within an international consortium investigating the genetics of Barrett's oesophagus and oesophageal adenocarcinoma, we aimed to identify novel genetic risk variants for the development of Barrett's oesophagus and oesophageal adenocarcinoma...
October 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27322014/dynamic-surfaces-for-the-study-of-mesenchymal-stem-cell-growth-through-adhesion-regulation
#14
Jemma N Roberts, Jugal Kishore Sahoo, Laura E McNamara, Karl V Burgess, Jingli Yang, Enateri V Alakpa, Hilary J Anderson, Jake Hay, Lesley-Anne Turner, Stephen J Yarwood, Mischa Zelzer, Richard O C Oreffo, Rein V Ulijn, Matthew J Dalby
Out of their niche environment, adult stem cells, such as mesenchymal stem cells (MSCs), spontaneously differentiate. This makes both studying these important regenerative cells and growing large numbers of stem cells for clinical use challenging. Traditional cell culture techniques have fallen short of meeting this challenge, but materials science offers hope. In this study, we have used emerging rules of managing adhesion/cytoskeletal balance to prolong MSC cultures by fabricating controllable nanoscale cell interfaces using immobilized peptides that may be enzymatically activated to change their function...
July 26, 2016: ACS Nano
https://www.readbyqxmd.com/read/27265454/pneumococcal-vaccine-impact-on-otitis-media-microbiology-a-new-zealand-cohort-study-before-and-after-the-introduction-of-phid-cv10-vaccine
#15
Emma J Best, Tony Walls, Melanie Souter, Michel Neeff, Trevor Anderson, Lesley Salkeld, Zahoor Ahmad, Murali Mahadevan, Cameron Walker, David Murdoch, Nikki Mills
UNLABELLED: We compared the microbiology of middle ear fluid (MEF) in two cohorts of children having ventilation tube (VT) insertion; the first in the era of 7-valent Streptococcus pneumoniae conjugate vaccine (PCV7) and the second following introduction of the ten-valent pneumococcal vaccine (PHiD-CV10). METHODS: During 2011 (Phase 1) and again in 2014 (Phase 2) MEF and NP samples from 325 children and 319 children were taken at the time of VT insertion. A matched comparison group had NP swabs collected with 137 children (Phase 1) and 154 (Phase 2)...
July 19, 2016: Vaccine
https://www.readbyqxmd.com/read/27264393/inverse-association-between-gluteofemoral-obesity-and-risk-of%C3%A2-barrett-s-esophagus-in-a-pooled-analysis
#16
Bradley J Kendall, Joel H Rubenstein, Michael B Cook, Thomas L Vaughan, Lesley A Anderson, Liam J Murray, Nicholas J Shaheen, Douglas A Corley, Apoorva K Chandar, Li Li, Katarina B Greer, Amitabh Chak, Hashem B El-Serag, David C Whiteman, Aaron P Thrift
BACKGROUND & AIMS: Gluteofemoral obesity (determined by measurement of subcutaneous fat in the hip and thigh regions) could reduce risks of cardiovascular and diabetic disorders associated with abdominal obesity. We evaluated whether gluteofemoral obesity also reduces the risk of Barrett's esophagus (BE), a premalignant lesion associated with abdominal obesity. METHODS: We collected data from non-Hispanic white participants in 8 studies in the Barrett's and Esophageal Adenocarcinoma Consortium...
October 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27120520/the-starship-children-s-hospital-tonsillectomy-a-further-10-years-of-experience
#17
Murali Mahadevan, Graeme van der Meer, Maayan Gruber, Peter Reed, Conor Jackson, Colin Brown, Nikki Mills, Lesley J Salkeld, Michel Neeff, Jan Evans, Brian Anderson, Colin Barber
OBJECTIVES/HYPOTHESIS: Tonsillectomy as a day-stay procedure remains controversial, although it is an established procedure in New Zealand. We reviewed our last 10 years' experience. METHODS: A prospective audit was used to determine unplanned conversion from day-stay to overnight hospital admission rates and the incidence of postoperative complications. RESULTS: There were 5,400 tonsillectomies performed over the 10-year study period (January 2004-January 2015); 71% as outpatients...
April 27, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27015731/retraction-notice-to-increased-risk-of-stomach-and-esophageal-malignancies%C3%A2-in%C3%A2-people-with-aids-gastroenterology-2012-143-943-950-e2
#18
(no author information available yet)
No abstract text is available yet for this article.
April 2016: Gastroenterology
https://www.readbyqxmd.com/read/26948990/serum-%C3%AE-trace-protein-and-%C3%AE-2-microglobulin-as-predictors-of-esrd-mortality-and-cardiovascular-disease-in-adults-with-ckd-in-the-chronic-renal-insufficiency-cohort-cric-study
#19
Meredith C Foster, Josef Coresh, Chi-Yuan Hsu, Dawei Xie, Andrew S Levey, Robert G Nelson, John H Eckfeldt, Ramachandran S Vasan, Paul L Kimmel, Jeffrey Schelling, Michael Simonson, James H Sondheimer, Amanda Hyre Anderson, Sanjeev Akkina, Harold I Feldman, John W Kusek, Akinlolu O Ojo, Lesley A Inker
BACKGROUND: Serum β-trace protein (BTP) and β2-microglobulin (B2M) are independently associated with end-stage renal disease (ESRD) and mortality in the general population and high-risk groups with diabetes or advanced chronic kidney disease (CKD). Less is known about their associations with outcomes and predictive ability in adults with moderate CKD. STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: 3,613 adults from the CRIC (Chronic Renal Insufficiency Cohort) Study (45% women; mean age, 57...
July 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26546850/intergrowth-21st-vs-customized-birthweight-standards-for-identification-of-perinatal-mortality-and-morbidity
#20
Ngaire H Anderson, Lynn C Sadler, Christopher J D McKinlay, Lesley M E McCowan
BACKGROUND: The recently published INTERGROWTH-21st Project international population standard for newborn size is intended for global use, but its ability to identify small infants at risk of adverse outcomes in a general obstetric population has not been reported. OBJECTIVE: The objective of the study was to compare adverse neonatal outcomes among small-for-gestational-age (SGA) infants between the INTERGROWTH-21st standard and a customized birthweight standard (accounting for maternal characteristics of height, weight, parity, and ethnicity)...
April 2016: American Journal of Obstetrics and Gynecology
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