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JOURNAL ARTICLE
Jasneet Parmar, Tanya L'Heureux, Michelle Lobchuk, Jamie Penner, Lesley Charles, Oona St Amant, Catherine Ward-Griffin, Sharon Anderson
The COVID-19 pandemic has considerably strained health care providers and family caregivers. Double-duty caregivers give unpaid care at home and are employed as care providers. This sequential mixed-method study, a survey followed by qualitative interviews, aimed to comprehensively understand the experiences of these Canadian double-duty caregivers amidst the pandemic and the transition to the endemic phase. The multi-section survey included standardized assessments such as the Double-duty Caregiver Scale and the State Anxiety Scale, along with demographic, employment-related, and care work questions...
2024: PloS One
#2
JOURNAL ARTICLE
Jasneet Parmar, Sara Hafeez, Tanya L'Heureux, Lesley Charles, Josephine Tite, Peter George J Tian, Sharon Anderson
BACKGROUND: One in four Canadians is a family caregiver. Family caregivers (carers, care-partners) are relatives or chosen family, friends, or neighbors who provide 75 to 90% of the care for people with physical or mental illness, disabilities, or frailty living in community homes and assist with 15 to 30% of the care in congregate care. However, a recent (2022) Statistics Canada population health study reports 44% of family caregivers are distressed. Family physicians and primary care teams are well-positioned to support family caregivers; yet, family caregiver needs assessments tend to be ad hoc and their most common needs remain unmet...
March 7, 2024: BMC Prim Care
#3
JOURNAL ARTICLE
Suvi T Vaara, Ary Serpa Neto, Rinaldo Bellomo, Neill K J Adhikari, Didier Dreyfuss, Martin Gallagher, Stephane Gaudry, Eric Hoste, Michael Joannidis, Ville Pettilä, Amanda Y Wang, Kianoush Kashani, Ron Wald, Sean M Bagshaw, Marlies Ostermann
OBJECTIVES: Among patients with severe acute kidney injury (AKI) admitted to the ICU in high-income countries, regional practice variations for fluid balance (FB) management, timing, and choice of renal replacement therapy (RRT) modality may be significant. DESIGN: Secondary post hoc analysis of the STandard vs. Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial (ClinicalTrials.gov number NCT02568722). SETTING: One hundred-fifty-three ICUs in 13 countries...
February 2024: Critical care explorations
#4
JOURNAL ARTICLE
Clarisse F de Vries, Roger T Staff, Jaroslaw A Dymiter, Moragh Boyle, Lesley A Anderson, Gerald Lip
OBJECTIVES: To determine factors influencing reader agreement in breast screening and investigate the relationship between agreement level and patient outcomes. METHODS: Reader pair agreement for 83 265 sets of mammograms from the Scottish Breast Screening service (2015-2020) was evaluated using Cohen's kappa statistic. Each mammography examination was read by two readers, per routine screening practice, with the second initially blinded but able to choose to view the first reader's opinion...
January 23, 2024: British Journal of Radiology
#5
JOURNAL ARTICLE
Esti de Graaff, Ngaire Anderson, Lynn Sadler, Heena Lakhdhir, Rachel Simon-Kumar, Roshini Peiris-John, Wendy Burgess, Karaponi Okesene-Gafa, Robin Cronin, Lesley McCowan, Kate Bartlett
INTRODUCTION: Reliability studies of placental examination have shown differing interobserver agreement for certain pathological features, a lack of uniform reporting criteria and variable experience among pathologists. In previous analyses we have shown that placental pathology differs by ethnicity. This validation study was performed to investigate whether bias related to ethnicity is a feature of placental pathology reporting in New Zealand (NZ). METHODS: 199 of 1726 eligible perinatal death cases between 2008 and 2017 were selected at random for this audit-type study, including 51 cases from South Asian, Māori and NZ European ethnicity and 46 cases from Pacific mothers...
December 15, 2023: Placenta
#6
JOURNAL ARTICLE
Nouf Abutheraa, Emma-Louise Tarburn, Charlene M McShane, Andrew Duncombe, Mary Frances McMullin, Lesley Ann Anderson
BACKGROUND: Myeloproliferative neoplasms (MPNs) are a group of haematological malignancies that affect approximately 8 people in every 100,000 individuals in the UK. Little is known about the aetiology of MPNs, as previous studies have been hampered by small sample sizes, thus it is important to understand the cause of MPNs in a larger study to identify prevention strategies and improve treatment strategies. This study aims to determine environmental, lifestyle, genetic and medical causes of MPNs and to assess the relevance of occupational carcinogen exposures and quality of life impacts...
December 7, 2023: BMC Cancer
#7
JOURNAL ARTICLE
Lai Yee Orbell, Nouf Abutheraa, Andrew S Duncombe, Mary Frances McMullin, Ruben Mesa, Charlene M McShane, Glen James, Lesley A Anderson
Alleviating symptom burden in patients with myeloproliferative neoplasms (MPNs) is imperative to achieving optimal management. Research remains to elucidate the relationship between the JAK2V617F ( Janus kinase 2 ) mutation present in many MPN patients, and the symptomatology they experience. This retrospective study analysed data collected from MPN patients included in the Myeloproliferative Neoplasms: An In-depth Case-Control (MOSAICC) pilot study. The MPN Symptom Assessment Form was administered, and median symptom scores were compared between JAK2V617F -positive and JAK2V617F -negative groups...
November 2023: EJHaem
#8
JOURNAL ARTICLE
John S Moin, Simone N Vigod, Lesley Plumptre, Natalie Troke, Irene Papanicolas, Walter P Wodchis, Geoff Anderson
BACKGROUND: The COVID-19 pandemic and nonpharmaceutical interventions that reduced the spread of infection had impacts on social interaction, schooling and employment. Concerns have been raised about the impact of these disruptions on the mental health of high-risk groups, including birthing parents of young children. METHODS: This population-based, repeated cross-sectional study used health administrative databases in Ontario, Canada, to link children to birth parents and to measure subsequent mental health visits of birthing parents of younger (age 0-5 yr) and school-aged (6-12 yr) children...
2023: CMAJ Open
#9
JOURNAL ARTICLE
Netsanet Bogale, Bargude Balta, Gulema Demissie, Dereje Geleta, Michele Rakoff, Brandon Anderson, Natalie Johnson, Lisa Yee, Lesley Taylor
PURPOSE: The aim of this study was to explore breast cancer (BC) challenges to identify opportunities for advocacy in southern Ethiopia in 2022. METHODS: Twenty-five participants from four local districts (kebeles) in Hawassa City were selected as key contributors to future work. Semistructured in-depth interviews were held for two clinicians, two local health bureau managers, two media managers, and three religious leaders. Two focus group discussions were conducted: one included six BC survivors and a caregiver; the other included two health extension workers, three members of the Women's Development Group, two community volunteers, one kebele leader, and one traditional healer...
September 2023: JCO global oncology
#10
JOURNAL ARTICLE
John S Moin, Simone N Vigod, Lesley Plumptre, Natalie Troke, Miqdad Asaria, Irene Papanicolas, Walter P Wodchis, Shauna Brail, Geoff Anderson
OBJECTIVES: The pandemic and public health response to contain the virus had impacts on many aspects of young people's lives including disruptions to daily routines, opportunities for social, academic, recreational engagement and early employment. Consequently, children, adolescents and young adults may have experienced mental health challenges that required use of mental health services. This study compared rates of use for inpatient and outpatient mental health services during the pandemic to pre-pandemic rates...
November 1, 2023: BMJ Open
#11
JOURNAL ARTICLE
Morgan E Grams, Josef Coresh, Kunihiro Matsushita, Shoshana H Ballew, Yingying Sang, Aditya Surapaneni, Natalia Alencar de Pinho, Amanda Anderson, Lawrence J Appel, Johan Ärnlöv, Fereidoun Azizi, Nisha Bansal, Samira Bell, Henk J G Bilo, Nigel J Brunskill, Juan J Carrero, Steve Chadban, John Chalmers, Jing Chen, Elizabeth Ciemins, Massimo Cirillo, Natalie Ebert, Marie Evans, Alejandro Ferreiro, Edouard L Fu, Masafumi Fukagawa, Jamie A Green, Orlando M Gutierrez, William G Herrington, Shih-Jen Hwang, Lesley A Inker, Kunitoshi Iseki, Tazeen Jafar, Simerjot K Jassal, Vivekanand Jha, Aya Kadota, Ronit Katz, Anna Köttgen, Tsuneo Konta, Florian Kronenberg, Brian J Lee, Jennifer Lees, Adeera Levin, Helen C Looker, Rupert Major, Cheli Melzer Cohen, Makiko Mieno, Mariko Miyazaki, Olivier Moranne, Isao Muraki, David Naimark, Dorothea Nitsch, Wonsuk Oh, Michelle Pena, Tanjala S Purnell, Charumathi Sabanayagam, Michihiro Satoh, Simon Sawhney, Elke Schaeffner, Ben Schöttker, Jenny I Shen, Michael G Shlipak, Smeeta Sinha, Benedicte Stengel, Keiichi Sumida, Marcello Tonelli, Jose M Valdivielso, Arjan D van Zuilen, Frank L J Visseren, Angela Yee-Moon Wang, Chi-Pang Wen, David C Wheeler, Hiroshi Yatsuya, Kunihiro Yamagata, Jae Won Yang, Ann Young, Haitao Zhang, Luxia Zhang, Andrew S Levey, Ron T Gansevoort
IMPORTANCE: Chronic kidney disease (low estimated glomerular filtration rate [eGFR] or albuminuria) affects approximately 14% of adults in the US. OBJECTIVE: To evaluate associations of lower eGFR based on creatinine alone, lower eGFR based on creatinine combined with cystatin C, and more severe albuminuria with adverse kidney outcomes, cardiovascular outcomes, and other health outcomes. DESIGN, SETTING, AND PARTICIPANTS: Individual-participant data meta-analysis of 27 503 140 individuals from 114 global cohorts (eGFR based on creatinine alone) and 720 736 individuals from 20 cohorts (eGFR based on creatinine and cystatin C) and 9 067 753 individuals from 114 cohorts (albuminuria) from 1980 to 2021...
October 3, 2023: JAMA
#12
JOURNAL ARTICLE
Louise Allan, Abby O'Connell, Shruti Raghuraman, Alison Bingham, Abigail Laverick, Kirstie Chandler, James Connors, Benjamin Jones, Jinpil Um, Sarah Morgan-Trimmer, Rowan Harwood, Victoria A Goodwin, Obioha C Ukoumunne, Annie Hawton, Rob Anderson, Thomas Jackson, Alasdair M J MacLullich, Sarah Richardson, Daniel Davis, Lesley Collier, William David Strain, Rachael Litherland, Jon Glasby, Linda Clare
BACKGROUND: Delirium affects over 20% of all hospitalised older adults. Delirium is associated with a number of adverse outcomes following hospital admission including cognitive decline, anxiety and depression, increased mortality and care needs. Previous research has addressed prevention of delirium in hospitals and care homes, and there are guidelines on short-term treatment of delirium during admission. However, no studies have addressed the problem of longer-term recovery after delirium and it is currently unknown whether interventions to improve recovery after delirium are effective and cost-effective...
September 15, 2023: Pilot and Feasibility Studies
#13
Sonja I Berndt, Joseph Vijai, Yolanda Benavente, Nicola J Camp, Alexandra Nieters, Zhaoming Wang, Karin E Smedby, Geffen Kleinstern, Henrik Hjalgrim, Caroline Besson, Christine F Skibola, Lindsay M Morton, Angela R Brooks-Wilson, Lauren R Teras, Charles Breeze, Joshua Arias, Hans-Olov Adami, Demetrius Albanes, Kenneth C Anderson, Stephen M Ansell, Bryan Bassig, Nikolaus Becker, Parveen Bhatti, Brenda M Birmann, Paolo Boffetta, Paige M Bracci, Paul Brennan, Elizabeth E Brown, Laurie Burdett, Lisa A Cannon-Albright, Ellen T Chang, Brian C H Chiu, Charles C Chung, Jacqueline Clavel, Pierluigi Cocco, Graham Colditz, Lucia Conde, David V Conti, David G Cox, Karen Curtin, Delphine Casabonne, Immaculata De Vivo, Arjan Diepstra, W Ryan Diver, Ahmet Dogan, Christopher K Edlund, Lenka Foretova, Joseph F Fraumeni, Attilio Gabbas, Hervé Ghesquières, Graham G Giles, Sally Glaser, Martha Glenn, Bengt Glimelius, Jian Gu, Thomas M Habermann, Christopher A Haiman, Corinne Haioun, Jonathan N Hofmann, Theodore R Holford, Elizabeth A Holly, Amy Hutchinson, Aalin Izhar, Rebecca D Jackson, Ruth F Jarrett, Rudolph Kaaks, Eleanor Kane, Laurence N Kolonel, Yinfei Kong, Peter Kraft, Anne Kricker, Annette Lake, Qing Lan, Charles Lawrence, Dalin Li, Mark Liebow, Brian K Link, Corrado Magnani, Marc Maynadie, James McKay, Mads Melbye, Lucia Miligi, Roger L Milne, Thierry J Molina, Alain Monnereau, Rebecca Montalvan, Kari E North, Anne J Novak, Kenan Onel, Mark P Purdue, Kristin A Rand, Elio Riboli, Jacques Riby, Eve Roman, Gilles Salles, Douglas W Sborov, Richard K Severson, Tait D Shanafelt, Martyn T Smith, Alexandra Smith, Kevin W Song, Lei Song, Melissa C Southey, John J Spinelli, Anthony Staines, Deborah Stephens, Heather J Sutherland, Kaitlyn Tkachuk, Carrie A Thompson, Hervé Tilly, Lesley F Tinker, Ruth C Travis, Jenny Turner, Celine M Vachon, Claire M Vajdic, Anke Van Den Berg, David J Van Den Berg, Roel C H Vermeulen, Paolo Vineis, Sophia S Wang, Elisabete Weiderpass, George J Weiner, Stephanie Weinstein, Nicole Wong Doo, Yuanqing Ye, Meredith Yeager, Kai Yu, Anne Zeleniuch-Jacquotte, Yawei Zhang, Tongzhang Zheng, Elad Ziv, Joshua Sampson, Nilanjan Chatterjee, Kenneth Offit, Wendy Cozen, Xifeng Wu, James R Cerhan, Stephen J Chanock, Susan L Slager, Nathaniel Rothman
No abstract text is available yet for this article.
September 4, 2023: Leukemia
#14
JOURNAL ARTICLE
Varsha Neelam, Kate R Woodworth, Daniel J Chang, Nicole M Roth, Megan R Reynolds, Amanda Akosa, Christopher P Carr, Kayla N Anderson, Sarah B Mulkey, Roberta L DeBiasi, Cara Biddle, Ellen H Lee, Amanda L Elmore, Sarah J Scotland, Similoluwa Sowunmi, Nicole D Longcore, Muhammad Ahmed, Peter H Langlois, Salma Khuwaja, Shea Elizabeth Browne, Leah Lind, Kyoo Shim, Michael Gosciminski, Rachel Blumenfeld, Shreya Khuntia, Umme-Aiman Halai, Autumn Locklear, Mary Chan, Teri' Willabus, Julius Tonzel, Natalie S Marzec, Nianest Alers Barreto, Connie Sanchez, Jane Fornoff, Shelby Hale, Amy Nance, Lisa Iguchi, Sowmya N Adibhatla, Emily Potts, Elizabeth Schiffman, Devin Raman, Morgan F McDonald, Brandi Stricklin, Elizabeth Ludwig, Lindsay Denson, Dianna Contreras, Paul A Romitti, Emily Ferrell, Meghan Marx, Kimberly Signs, Amie Cook, Vinita Oberoi Leedom, Suzann Beauregard, Lucia C Orantes, Laura Cronquist, Lesley Roush, Shana Godfred-Cato, Suzanne M Gilboa, Dana Meaney-Delman, Margaret A Honein, Cynthia A Moore, Van T Tong
BACKGROUND: To characterize neurodevelopmental abnormalities in children up to 36 months of age with congenital Zika virus exposure. METHODS: From the U.S. Zika Pregnancy and Infant Registry, a national surveillance system to monitor pregnancies with laboratory evidence of Zika virus infection, pregnancy outcomes and presence of Zika associated birth defects (ZBD) were reported among infants with available information. Neurologic sequelae and developmental delay were reported among children with ≥1 follow-up exam after 14 days of age or with ≥1 visit with development reported, respectively...
September 1, 2023: Pediatric Research
#15
JOURNAL ARTICLE
Dominic Habgood-Coote, Clare Wilson, Chisato Shimizu, Anouk M Barendregt, Ria Philipsen, Rachel Galassini, Irene Rivero Calle, Lesley Workman, Philipp K A Agyeman, Gerben Ferwerda, Suzanne T Anderson, J Merlijn van den Berg, Marieke Emonts, Enitan D Carrol, Colin G Fink, Ronald de Groot, Martin L Hibberd, John Kanegaye, Mark P Nicol, Stéphane Paulus, Andrew J Pollard, Antonio Salas, Fatou Secka, Luregn J Schlapbach, Adriana H Tremoulet, Michael Walther, Werner Zenz, Michiel Van der Flier, Heather J Zar, Taco Kuijpers, Jane C Burns, Federico Martinón-Torres, Victoria J Wright, Lachlan J M Coin, Aubrey J Cunnington, Jethro A Herberg, Michael Levin, Myrsini Kaforou
BACKGROUND: Appropriate treatment and management of children presenting with fever depend on accurate and timely diagnosis, but current diagnostic tests lack sensitivity and specificity and are frequently too slow to inform initial treatment. As an alternative to pathogen detection, host gene expression signatures in blood have shown promise in discriminating several infectious and inflammatory diseases in a dichotomous manner. However, differential diagnosis requires simultaneous consideration of multiple diseases...
August 11, 2023: Med
#16
JOURNAL ARTICLE
Tanya J Murphy, Hanna Swail, Jaspreet Jain, Maureen Anderson, Philip Awadalla, Lesley Behl, Patrick E Brown, Carmen L Charlton, Karen Colwill, Steven J Drews, Anne-Claude Gingras, Deena Hinshaw, Prabhat Jha, Jamil N Kanji, Victoria A Kirsh, Amanda L S Lang, Marc-André Langlois, Stephen Lee, Antoine Lewin, Sheila F O'Brien, Chantale Pambrun, Kimberly Skead, David A Stephens, Derek R Stein, Graham Tipples, Paul G Van Caeseele, Timothy G Evans, Olivia Oxlade, Bruce D Mazer, David L Buckeridge
BACKGROUND: During the first year of the COVID-19 pandemic, the proportion of reported cases of COVID-19 among Canadians was under 6%. Although high vaccine coverage was achieved in Canada by fall 2021, the Omicron variant caused unprecedented numbers of infections, overwhelming testing capacity and making it difficult to quantify the trajectory of population immunity. METHODS: Using a time-series approach and data from more than 900 000 samples collected by 7 research studies collaborating with the COVID-19 Immunity Task Force (CITF), we estimated trends in SARS-CoV-2 seroprevalence owing to infection and vaccination for the Canadian population over 3 intervals: prevaccination (March to November 2020), vaccine roll-out (December 2020 to November 2021), and the arrival of the Omicron variant (December 2021 to March 2023)...
August 14, 2023: Canadian Medical Association Journal: CMAJ
#17
JOURNAL ARTICLE
Susanne Maxwell, Clara Pearce, Mary Kynn, Lesley Ann Anderson, David Weller, Peter Murchie
BACKGROUND: In Scotland 17 % of the population reside rurally and previous research has demonstrated worse cancer outcomes in this group. The underlying reason for this is unclear. This study aims to determine whether patient presenting factors, GP consultation factors or the diagnostic pathways differ between urban and rural patients within Scotland. METHODS: This study combined two Scottish National Cancer Diagnosis Audits. Participating GPs collected data on the diagnostic pathway from primary to secondary care for cancer patients diagnosed during the audit period...
July 25, 2023: Cancer Epidemiology
#18
JOURNAL ARTICLE
Esti de Graaff, Lynn Sadler, Heena Lakhdhir, Rachel Simon-Kumar, Roshini Peiris-John, Wendy Burgess, Karaponi Okesene-Gafa, Robin Cronin, Lesley McCowan, Ngaire Anderson
BACKGROUND: International and national New Zealand (NZ) research has identified women of South Asian ethnicity at increased risk of perinatal mortality, in particular stillbirth, with calls for increased perinatal research among this ethnic group. We aimed to analyse differences in pregnancy outcomes and associated risk factors between South Asian, Māori, Pacific and NZ European women in Aotearoa NZ, with a focus on women of South Asian ethnicity, to ultimately understand the distinctive pathways leading to adverse events...
July 24, 2023: BMC Pregnancy and Childbirth
#19
JOURNAL ARTICLE
Michal Nisnboym, Sarah R Vincze, Zujian Xiong, Chaim T Sneiderman, Rebecca A Raphael, Bo Li, Ambika P Jaswal, ReidAnn E Sever, Kathryn E Day, Joseph D LaToche, Lesley M Foley, Hanieh Karimi, T Kevin Hitchens, Sameer Agnihotri, Baoli Hu, Dhivyaa Rajasundaram, Carolyn J Anderson, Deborah T Blumenthal, Thomas M Pearce, Shikhar Uttam, Jessie R Nedrow, Ashok Panigrahy, Ian F Pollack, Frank S Lieberman, Jan Drappatz, Itay Raphael, Wilson B Edwards, Gary Kohanbash
UNLABELLED: Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. Immunotherapy may be promising for the treatment of some patients with GBM; however, there is a need for noninvasive neuroimaging techniques to predict immunotherapeutic responses. The effectiveness of most immunotherapeutic strategies requires T-cell activation. Therefore, we aimed to evaluate an early marker of T-cell activation, CD69, for its use as an imaging biomarker of response to immunotherapy for GBM...
July 2023: Cancer Res Commun
#20
JOURNAL ARTICLE
Lesley Dixon, Shanti Daellenbach, Jacqui Anderson, Eva Neely, Arianna Nisa-Waller, Sarah Lockwood
PROBLEM/BACKGROUND: Respectful woman-centred care is an expectation of the Midwifery Standards of Practice within Aotearoa New Zealand. With both the national and international expectations identifying human rights as a priority in maternity care. Mistreatment can be experienced by women in all socio-political contexts. Identifying women's experiences of their maternity service is vital when assessing the quality of these services. AIM: To explore women's experiences of continuity of midwifery care in Aotearoa NZ, whether they support the expectations within the Standards of Midwifery Practice and identify the characteristics of care that may contribute to positive or negative experiences of care...
July 6, 2023: Women and Birth
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