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IL-22 binding protein

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https://www.readbyqxmd.com/read/28194325/serum-yb-1-y-box-binding-protein-1-as-a-biomarker-of-bone-disease-progression-in-patients-with-breast-cancer-and-bone-metastases
#1
A R Ferreira, M Bettencourt, I Alho, A L Costa, A R Sousa, A Mansinho, C Abreu, C Pulido, D Macedo, I Vendrell, T R Pacheco, L Costa, S Casimiro
YB-1 (Y-box binding protein 1) is a multifunctional cold-shock protein that has been implicated in all hallmarks of cancer. Elevated YB-1 protein level was associated with poor prognosis in several types of cancers, including breast cancer (BC), where it is a marker of decreased overall survival (OS) and distant metastasis-free survival across all subtypes. YB-1 is also secreted by different cell types and may act as an extracellular mitogen; however the pathological implications of the secreted form of YB-1 (sYB-1) are unknown...
March 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/28127403/campylobacter-jejuni-infection-of-conventionally-colonized-mice-lacking-nucleotide-oligomerization-domain-2
#2
Stefan Bereswill, Ursula Grundmann, Marie E Alutis, André Fischer, Markus M Heimesaat
BACKGROUND: The nucleotide-binding oligomerisaton protein 2 (NOD2) constitutes a pivotal sensor of bacterial muramyl dipeptide and assures expression of distinct antimicrobial peptides and mediators produced by enterocytes and immune cells directed against pathogens including Campylobacter jejuni. We here elucidated the role of NOD2 during murine C. jejuni infection in more detail. RESULTS: Conventionally colonized NOD2 deficient (NOD2(-/-)) mice and corresponding wildtype (WT) counterparts were perorally infected with C...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28125840/association-of-high-mobility-group-box-1-with-th-cell-related-cytokines-in-the-vitreous-of-ocular-sarcoidosis-patients
#3
Masaru Takeuchi, Manzo Taguchi, Tomohito Sato, Kyoko Karasawa, Yutaka Sakurai, Kohzou Harimoto, Masataka Ito
Purpose: High-mobility group box-1 (HMGB1) is a nonhistone DNA-binding nuclear protein released from necrotic cells, which is also secreted by activated leukocytes and acts as a primary proinflammatory cytokine. In this study, we compared vitreous HMGB1 levels in ocular sarcoidosis with those in noninflammatory vitreoretinal diseases and evaluated its association with Th cell-related and proinflammatory cytokines. Methods: The study group consisted of 24 patients with ocular sarcoidosis...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28081037/higher-cd163-levels-are-associated-with-insulin-resistance-in-hepatitis-c-virus-infected-and-hiv-infected-adults
#4
Michael Reid, Yifei Ma, Rebecca Scherzer, Jennifer C Price, Audrey L French, Michael W Plankey, Carl Grunfeld, Phyllis C Tien
OBJECTIVES: HIV/hepatitis C virus (HCV) coinfection is associated with insulin resistance, but the mechanism is unclear. We hypothesized that intestinal epithelial damage and the consequent monocyte/macrophage activation and inflammation explain this perturbation. DESIGN: Cross-sectional study of 519 adults (220 HIV+/HCV-; 64 HIV-/HCV+; 89 HIV+/HCV+; 146 HIV-/HCV-). METHODS: We used multivariable linear regression to evaluate associations of HIV and HCV with the homeostasis model assessment of insulin resistance (HOMA-IR) and if intestinal fatty (FA) acid binding protein (I-FABP, a marker of gut epithelial integrity), soluble CD14 (sCD14) and soluble CD163 (sCD163) (markers of monocyte/macrophage activation), and IL-6 (an inflammatory cytokine) mediated this association...
January 28, 2017: AIDS
https://www.readbyqxmd.com/read/27995575/cerebrospinal-fluid-biomarkers-and-hiv-associated-neurocognitive-disorders-in-hiv-infected-individuals-in-rakai-uganda
#5
Mahsa Abassi, Bozena M Morawski, Gertrude Nakigozi, Noeline Nakasujja, Xiangrong Kong, David B Meya, Kevin Robertson, Ronald Gray, Maria J Wawer, Ned Sacktor, David R Boulware
In the USA, increased cerebrospinal fluid (CSF) inflammatory cytokines have been observed in antiretroviral therapy (ART)-naive, HIV-seropositive individuals with HIV-associated neurocognitive disorder (HAND). We characterized the relationship between HAND and CSF biomarker expression in ART-naive, HIV-seropositive individuals in Rakai, Uganda. We analyzed CSF of 78 HIV-seropositive, ART-naive Ugandan adults for 17 cytokines and 20 neurodegenerative biomarkers via Luminex multiplex assay. These adults underwent neurocognitive assessment to determine their degree of HAND...
December 19, 2016: Journal of Neurovirology
https://www.readbyqxmd.com/read/27915442/co-exposure-to-low-doses-of-the-food-contaminants-deoxynivalenol-and-nivalenol-has-a-synergistic-inflammatory-effect-on-intestinal-explants
#6
Imourana Alassane-Kpembi, Olivier Puel, Philippe Pinton, Anne-Marie Cossalter, Ting-Chao Chou, Isabelle P Oswald
The global incidence of Fusarium head blight and attendant cereal grains multi-contamination by the trichothecene mycotoxins deoxynivalenol (DON) and nivalenol (NIV) are increasing as a possible result of climate change and inadequate agricultural practices. At the molecular level, these mycotoxins bind to the ribosome, activate the mitogen-activated protein kinase and induce a local and systemic inflammation. DON is of public health concern owing to the narrow margin between exposure and tolerable daily intake...
December 3, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27905482/pharmacologic-modulation-of-ror%C3%AE-t-translates-to-efficacy-in-preclinical-and-translational-models-of-psoriasis-and-inflammatory-arthritis
#7
Xiaohua Xue, Pejman Soroosh, Aimee De Leon-Tabaldo, Rosa Luna-Roman, Marciano Sablad, Natasha Rozenkrants, Jingxue Yu, Glenda Castro, Homayon Banie, Wai-Ping Fung-Leung, Luis Santamaria-Babi, Thomas Schlueter, Michael Albers, Kristi Leonard, Alison L Budelsky, Anne M Fourie
The IL-23/IL-17 pathway is implicated in autoimmune diseases, particularly psoriasis, where biologics targeting IL-23 and IL-17 have shown significant clinical efficacy. Retinoid-related orphan nuclear receptor gamma t (RORγt) is required for Th17 differentiation and IL-17 production in adaptive and innate immune cells. We identified JNJ-54271074, a potent and highly-selective RORγt inverse agonist, which dose-dependently inhibited RORγt-driven transcription, decreased co-activator binding and promoted interaction with co-repressor protein...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27882145/microrna-22-attenuates-myocardial-ischemia-reperfusion-injury-via-an-anti-inflammatory-mechanism-in-rats
#8
Jian Yang, Zhixing Fan, Jun Yang, Jiawang Ding, Chaojun Yang, Lihua Chen
Previous studies have reported that microRNA-22 (miR-22) may be implicated in ischemia-reperfusion (I/R)-induced myocardial injury. Our previously published data also demonstrated that miR-22 may protect against myocardial I/R injury via anti-apoptosis in rats by targeting cAMP response element-binding protein binding protein (CBP). However, the specific function of miR-22 in myocardial I/R injury is far from fully elucidated. The present study was designed to investigate another cardioprotective signaling mechanism of miR-22 in myocardial I/R injury...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27872753/multifunctional-thioredoxin-like-protein-from-the-gastrointestinal-parasitic-nematodes-strongyloides-ratti-and-trichuris-suis-affects-mucosal-homeostasis
#9
Dana Ditgen, Emmanuela M Anandarajah, Jan Hansmann, Dominic Winter, Guido Schramm, Klaus D Erttmann, Eva Liebau, Norbert W Brattig
The cellular redox state is important for the regulation of multiple functions and is essential for the maintenance of cellular homeostasis and antioxidant defense. In the excretory/secretory (E/S) products of Strongyloides ratti and Trichuris suis sequences for thioredoxin (Trx) and Trx-like protein (Trx-lp) were identified. To characterize the antioxidant Trx-lp and its interaction with the parasite's mucosal habitat, S. ratti and T. suis Trx-lps were cloned and recombinantly expressed. The primary antioxidative activity was assured by reduction of insulin and IgM...
2016: Journal of Parasitology Research
https://www.readbyqxmd.com/read/27846573/a-pathogenic-role-for-t-cell-derived-il-22bp-in-inflammatory-bowel-disease
#10
Penelope Pelczar, Mario Witkowski, Laura Garcia Perez, Jan Kempski, Anna G Hammel, Leonie Brockmann, Dörte Kleinschmidt, Sandra Wende, Cathleen Haueis, Tanja Bedke, Marco Witkowski, Susanne Krasemann, Stefan Steurer, Carmen J Booth, Philipp Busch, Alexandra König, Ursula Rauch, Daniel Benten, Jakob R Izbicki, Thomas Rösch, Ansgar W Lohse, Till Strowig, Nicola Gagliani, Richard A Flavell, Samuel Huber
Intestinal inflammation can impair mucosal healing, thereby establishing a vicious cycle leading to chronic inflammatory bowel disease (IBD). However, the signaling networks driving chronic inflammation remain unclear. Here we report that CD4(+) T cells isolated from patients with IBD produce high levels of interleukin-22 binding protein (IL-22BP), the endogenous inhibitor of the tissue-protective cytokine IL-22. Using mouse models, we demonstrate that IBD development requires T cell-derived IL-22BP. Lastly, intestinal CD4(+) T cells isolated from IBD patients responsive to treatment with antibodies against tumor necrosis factor-α (anti-TNF-α), the most effective known IBD therapy, exhibited reduced amounts of IL-22BP expression but still expressed IL-22...
October 21, 2016: Science
https://www.readbyqxmd.com/read/27738869/elevated-serum-concentrations-of-lipopolysaccharide-binding-protein-might-prolong-sleep-stage-one-in-middle-aged-hypertensive-males
#11
Mulalibieke Heizhati, Nanfang Li, Liang Shao, Xiaoguang Yao, Yingchun Wang, Jing Hong, Ling Zhou, Delian Zhang, Guijuan Chang, Suofeiya Abulikemu
PURPOSE: Sleep architecture can be affected by alteration in circulating lipopolysaccaride and cytokines. However, still unknown are the effects of lipopolysaccaride-binding protein (LBP) on sleep architecture. Therefore, potential relationship between alteration in serum LBP concentrations and sleep architecture was analyzed. METHODS: This is a cross-sectional study. Consecutive 54 hypertensive males, aged 30-65 years. and with no obstructive sleep apnea via polysomnography, were recruited...
October 13, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27678220/human-il-22-binding-protein-isoforms-act-as-a-rheostat-for-il-22-signaling
#12
Chrissie Lim, MeeAe Hong, Ram Savan
The cytokine interleukin-22 (IL-22), which is a member of the IL-10 family, is produced exclusively by immune cells and activates signal transducer and activator of transcription 3 (STAT3) in nonimmune cells, such as hepatocytes, keratinocytes, and colonic epithelial cells, to drive various processes central to tissue homeostasis and immunosurveillance. Dysregulation of IL-22 signaling causes inflammatory diseases. IL-22 binding protein (IL-22BP; encoded by IL22RA2) is a soluble IL-22 receptor, which antagonizes IL-22 activity and has genetic associations with autoimmune diseases...
2016: Science Signaling
https://www.readbyqxmd.com/read/27537050/first-post-operative-urinary-kidney-injury-biomarkers-and-association-with-the-duration-of-aki-in-the-tribe-aki-cohort
#13
Steven G Coca, Girish N Nadkarni, Amit X Garg, Jay Koyner, Heather Thiessen-Philbrook, Eric McArthur, Michael G Shlipak, Chirag R Parikh
BACKGROUND: We previously demonstrated that assessment of the duration of AKI, in addition to magnitude of rise in creatinine alone, adds prognostic information for long-term survival. We evaluated whether post-operative kidney injury biomarkers in urine collected immediately after cardiac surgery associate with duration of serum creatinine elevation. METHODS: We studied 1199 adults undergoing cardiac surgery in a prospective cohort study (TRIBE-AKI) and examined the association between the levels of five urinary biomarkers individually at 0-6 hours after surgery: interleukin-18 (IL-18), neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), liver fatty acid binding protein (L-FABP) and albumin with duration of serum creatinine-based AKIN criteria for AKI (0 (no AKI), 1-2, 3-6, ≥7 days)...
2016: PloS One
https://www.readbyqxmd.com/read/27524110/the-aim2-inflammasome-is-a-central-regulator-of-intestinal-homeostasis-through-the-il-18-il-22-stat3-pathway
#14
Rojo A Ratsimandresy, Mohanalaxmi Indramohan, Andrea Dorfleutner, Christian Stehlik
Inflammasomes are important for maintaining intestinal homeostasis, and dysbiosis contributes to the pathology of inflammatory bowel disease (IBD) and increases the risk for colorectal cancer. Inflammasome defects contribute to chronic intestinal inflammation and increase the susceptibility to colitis in mice. However, the inflammasome sensor absent in melanoma 2 (AIM2) protects against colorectal cancer in an inflammasome-independent manner through DNA-dependent protein kinase and Akt pathways. Yet, the roles of the AIM2 inflammasome in IBD and the early phases of colorectal cancer remain ill-defined...
January 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/27496491/endocan-concentration-and-chronic-inflammatory-process-among-heart-transplant-recipients
#15
P Przybylowski, G Wasilewski, E Koc-Żórawska, J Malyszko
BACKGROUND: Endocan is a novel soluble dermatan sulfate proteoglycan derived from endothelium. It has the capacity of binding to different biologically active molecules associated with cellular signaling, adhesion, and regulating proliferation, differentiation, migration, and adhesion of different cell types in health and pathology. Its elevated level is connected with endothelial activation, neovascularization, and inflammation or carcinogenesis. METHODS: The level of serum endocan among 131 heart transplant recipients on 3-drug immunosuppression (calcineurin inhibitor, mycophenolate mofetil/mycophenolic acid, steroid) in correlation with other markers of endothelial damage was determined...
June 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27459270/a-novel-intrinsically-disordered-outer-membrane-lipoprotein-of-aggregatibacter-actinomycetemcomitans-binds-various-cytokines-and-plays-a-role-in-biofilm-response-to-interleukin-1%C3%AE-and-interleukin-8
#16
Tuuli Ahlstrand, Heidi Tuominen, Arzu Beklen, Annamari Torittu, Jan Oscarsson, Raija Sormunen, Marja T Pöllänen, Perttu Permi, Riikka Ihalin
Intrinsically disordered proteins (IDPs) do not have a well-defined and stable three-dimensional fold. Some IDPs can function as either transient or permanent binders of other proteins and may interact with an array of ligands by adopting different conformations. A novel outer membrane lipoprotein, bacterial interleukin receptor I (BilRI) of the opportunistic oral pathogen Aggregatibacter actinomycetemcomitans binds a key gatekeeper proinflammatory cytokine interleukin (IL)-1β. Because the amino acid sequence of the novel lipoprotein resembles that of fibrinogen binder A of Haemophilus ducreyi, BilRI could have the potential to bind other proteins, such as host matrix proteins...
July 26, 2016: Virulence
https://www.readbyqxmd.com/read/27268729/sparc-secreted-protein-acidic-and-rich-in-cysteine-of-the-intestinal-nematode-strongyloides-ratti-is-involved-in-mucosa-associated-parasite-host-interaction
#17
Emmanuela M Anandarajah, Dana Ditgen, Jan Hansmann, Klaus D Erttmann, Eva Liebau, Norbert W Brattig
The secreted protein acidic and rich in cysteine (SPARC), found in the excretory/secretory products of Strongyloides ratti, is most strongly expressed in parasitic females. Since SPARC proteins are involved in the modulation of cell-matrix interactions, a role of the secreted S. ratti SPARC (Sr-SPARC) in the manifestation of the parasite in the host's intestine is postulated. The full-length cDNA of Sr-SPARC was identified and the protein was recombinantly expressed. The purified protein was biologically active, able to bind calcium, and to attach to mucosa-associated human cells...
June 2016: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/27166675/the-role-of-interleukin-22-and-its-receptor-in-the-development-and-pathogenesis-of-experimental-autoimmune-uveitis
#18
Yejin Kim, Tae Wan Kim, Yun Seong Park, Eui Man Jeong, Dong-Sup Lee, In-Gyu Kim, Hum Chung, Young-Il Hwang, Wang Jae Lee, Hyeong Gon Yu, Jae Seung Kang
IL-22 is a pro- and anti-inflammatory cytokine that is mainly produced by T cells and NK cells. Recent studies have reported the increased number of IL-22 producing T cells in patients with autoimmune noninfectious uveitis; however, the correlation between IL-22 and uveitis remains unclear. In this study, we aimed to determine the specific role of IL-22 and its receptor in the pathogenesis of uveitis. Serum concentration of IL-22 was significantly increased in uveitis patients. IL-22Rα was expressed in the retinal pigment epithelial cell line, ARPE-19...
2016: PloS One
https://www.readbyqxmd.com/read/27117585/bacterial-superglue-enables-easy-development-of-efficient-virus-like-particle-based-vaccines
#19
Susan Thrane, Christoph M Janitzek, Sungwa Matondo, Mafalda Resende, Tobias Gustavsson, Willem Adriaan de Jongh, Stine Clemmensen, Will Roeffen, Marga van de Vegte-Bolmer, Geert Jan van Gemert, Robert Sauerwein, John T Schiller, Morten A Nielsen, Thor G Theander, Ali Salanti, Adam F Sander
BACKGROUND: Virus-like particles (VLPs) represent a significant advance in the development of subunit vaccines, combining high safety and efficacy. Their particulate nature and dense repetitive subunit organization makes them ideal scaffolds for display of vaccine antigens. Traditional approaches for VLP-based antigen display require labor-intensive trial-and-error optimization, and often fail to generate dense antigen display. Here we utilize the split-intein (SpyTag/SpyCatcher) conjugation system to generate stable isopeptide bound antigen-VLP complexes by simply mixing of the antigen and VLP components...
April 27, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27095254/disease-specific-dynamic-biomarkers-selected-by-integrating-inflammatory-mediators-with-clinical-informatics-in-ards-patients-with-severe-pneumonia
#20
Chengshui Chen, Lin Shi, Yuping Li, Xiangdong Wang, Shuanying Yang
Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome that occurs as a result of various risk factors, including either direct or indirect lung injury, and systemic inflammation triggered also by severe pneumonia (SP). SP-ARDS-associated morbidity and mortality remains high also due to the lack of disease-specific biomarkers. The present study aimed at identifying disease-specific biomarkers in SP or SP-ARDS by integrating proteomic profiles of inflammatory mediators with clinical informatics...
2016: Cell Biology and Toxicology
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