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https://www.readbyqxmd.com/read/27768920/nano-lc-ms-ms-for-the-identification-of-proteins-trapped-in-sorbent-cartridges-used-for-coupled-plasma-filtration-adsorption-treatments-of-healthy-pigs
#1
Donatella Nardiello, Clelia Prattichizzo, Maria Teresa Rocchetti, Loreto Gesualdo, Diego Centonze
A dedicated proteomic approach based on nano-Liquid Chromatography coupled with tandem mass spectrometry in ion trap is proposed for the analysis of proteins trapped in sorbent resin cartridges used to remove inflammatory mediators from blood by coupled plasma filtration adsorption (CPFA). The final purpose of the proposed proteomic approach was to obtain a reference map of plasma proteins trapped in CPFA sorbents used for the extracorporeal blood purification of healthy pigs, with the potential impact to design new bio-filters able to control the inflammatory imbalance under pathological conditions, such as severe sepsis...
October 12, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27263831/evaluation-of-the-punch-it%C3%A2-na-sample-kit-for-detecting-microbial-dna-in-blood-culture-bottles-using-pcr-reverse-blot-hybridization-assay
#2
Jungho Kim, Hye-Young Wang, Seoyong Kim, Soon Deok Park, Kwangmin Yu, Hyo Youl Kim, Young Uh, Hyeyoung Lee
DNA extraction efficiency affects the success of PCR-based method applications. The Punch-it™ NA-Sample kit for extracting DNA by using paper chromatography is technically easy to use and requires just two reagents and only 10min to complete. The Punch-it™ NA-Sample kit could be offered as a rapid, accurate, and convenient method for extracting bacterial and fungal DNA from blood culture bottles. We compared the efficiencies of the commercial kit (Punch-it™ NA-Sample kit) and an in-house conventional boiling method with Chelex-100 resin for DNA extraction from blood culture bottles...
September 2016: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/27092222/cloning-expression-and-purification-of-the-factor-h-binding-protein-and-its-interaction-with-factor-h
#3
Fatemeh Yarian, Mojgan Bandehpour, Negar Seyed, Bahram Kazemi
BACKGROUND AND OBJECTIVE: Neisseria meningitidis is a leading cause of meningitis and sepsis worldwide. The factor H binding protein (fHBP) is a key virulence factor of Neisseria meningitidis that is able to selectively bind to human factor H, the key regulator of the alternative complement pathway, which it has important implications for meningococcal pathogenesis and vaccine design. The aims of present research were cloning, expression, purification of fHbp and confirmation of the interaction between serum factor H (fH) and produced factor H binding protein...
February 2016: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/26488754/adsorption-of-selected-antibiotics-to-resins-in-extracorporeal-blood-purification
#4
Stephan Harm, Anna Gruber, Franz Gabor, Jens Hartmann
BACKGROUND/AIMS: Extracorporeal blood purification systems (EBS) use specific adsorbents for the elimination of toxins and cytokines. The aim of this study was to test different adsorbents for their ability to reduce antibiotics in parallel to extracorporeal blood purification therapy. METHODS: The in vitro adsorption experiments were carried out in human plasma with a newly established hydrophobic resin (Amberchrom CG161c) and adsorbents commercially available and approved in the clinics...
2016: Blood Purification
https://www.readbyqxmd.com/read/25984170/coupled-plasma-filtration-adsorption-for-the-treatment-of-a-patient-with-acute-respiratory-distress-syndrome-and-acute-kidney-injury-a-case-report
#5
Gaetano Lucisano, Maria Capria, Giovanni Matera, Pierangela Presta, Nicolino Comi, Roberta Talarico, Linda Rametti, Angela Quirino, Aida Giancotti, Giorgio Fuiano
Coupled plasma filtration adsorption (CPFA) is an extracorporeal blood purification therapy based on non-specific pro- and anti-inflammatory mediator adsorption on a special resin cartridge coupled with continuous veno-venous haemofiltration or continuous veno-venous haemodiafiltration and is one of the emerging treatments for septic patients. However, in the literature, there are limited data about its efficacy in treating patients with acute diseases but without the traditional criteria for sepsis. We describe the case of a 43-year-old male who developed acute respiratory distress syndrome secondary to pneumonia and acute kidney injury, whose clinical conditions rapidly improved after early CPFA therapy...
October 2011: NDT Plus
https://www.readbyqxmd.com/read/24511728/acute-intestinal-obstruction-due-to-kalimate-a-potassium-lowering-agent-a-case-report-and-literature-review
#6
REVIEW
Assanee Tongyoo, Ekkapak Sriussadaporn, Palin Limpavitayaporn, Chatchai Mingmalairak
Sodium polystyrene sulfonate (Kayexalate) and calcium polystyrene sulfonate (CPS, Kalimate) are commonly used to reduce serum potassium. There were some published evidences of severe gastrointestinal complications from the administration of these agents such as colonic necrosis with or without perforation and acute obstruction. The authors reported a 52-year-old male patient being critically ill from severe soft tissue infection of the right leg and sepsis. Hyperkalemia had occurred due to renal insufficiency and required several doses of Kalimate to reduce the serum potassium level...
December 2013: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
https://www.readbyqxmd.com/read/24270228/in-vivo-antibiotic-removal-during-coupled-plasma-filtration-adsorption-a-retrospective-study
#7
Mathieu Page, Sabine Cohen, Charles-Eric Ber, Bernard Allaouchiche, John A Kellum, Thomas Rimmelé
Coupled plasma filtration adsorption (CPFA) is a blood purification therapy aimed at modulating the host inflammatory response involved in sepsis pathogenesis. One potential drawback of this technique is the unexpected elimination of antibiotics. The aim of this study was to assess the elimination of several antibiotics with CPFA. We performed a retrospective analysis of the serum and ultrafiltrate concentrations of different antibiotics routinely measured during CPFA sessions in five patients experiencing septic shock...
January 2014: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/23954008/cytokine-removal-on-extracorporeal-life-support-for-treatment-of-acute-endotoxemia-a-randomized-controlled-animal-study
#8
Patrick W Weerwind, Frederik H van der Veen, Sandro Gelsomino, Naveen Gaddehosur Nagaraj, Orlando Parise, Roberto Lorusso, Gian Franco Gensini, Jos G Maessen
BACKGROUND: We prospectively evaluated the effectiveness of resin adsorption incorporated in an extracorporeal life support (ELS) circuit in an animal model of sepsis for removal of cytokines and prevention of hemodynamic deterioration during the treatment of septic shock. METHODS: Twelve female landrace pigs were randomly assigned to two groups, a study group(n=6), treated with high-flow resin adsorption (300 mL/min) and ELS, and a control group (n=6), treated only with ELS...
October 12, 2013: International Journal of Cardiology
https://www.readbyqxmd.com/read/23931889/effect-on-extrapulmonary-sepsis-induced-acute-lung-injury-by-hemoperfusion-with-neutral-microporous-resin-column
#9
RANDOMIZED CONTROLLED TRIAL
Zhao Huang, Si-rong Wang, Zi-li Yang, Ji-yun Liu
The aim of this study was to investigate the effect of neutral microporous resin hemoperfusion on oxygenation improvement, removal of inflammatory cytokines in plasma and bronchoalveolar lavage, and mortality in acute lung injury induced by extrapulmonary sepsis. Forty-six patients with acute lung injury induced by extrapulmonary sepsis were randomized to HA type hemoperfusion treatment (N=25) or standard therapy (N=21). Those undergoing hemoperfusion treatment received HA330 hemoperfusion. We measured the plasma and bronchoalveolar lavage concentrations of TNF-α and IL-1, and the following parameters were compared between the control group and the hemoperfusion group on days 0, 3 and 7: lung injury measurements (arterial oxygen tension/fractional inspired oxygen ratio, lung injury score, chest X-ray score); interstitial edema of lung (extravascular lung water)...
August 2013: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/23486710/neutralization-of-antimicrobial-substances-in-new-bact-alert-fa-and-fn-plus-blood-culture-bottles
#10
Dieter Mitteregger, Wolfgang Barousch, Marion Nehr, Michael Kundi, Markus Zeitlinger, Athanasios Makristathis, Alexander M Hirschl
Time to detection (TTD) in automated blood culture systems is delayed for sensitive microorganisms in the presence of antimicrobial substances and has been associated with worse outcomes for sepsis patients on inadequate empirical therapy. While resin addition removes antimicrobial substances to various degrees from blood culture media, media formulations and the blend of resins may influence performance. The BacT/Alert 3D system (bioMérieux) was investigated using the new resin-containing medium types FA Plus (aerobic) and FN Plus (anaerobic)...
May 2013: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/23438770/newly-designed-crrt-membranes-for-sepsis-and-sirs-a-pragmatic-approach-for-bedside-intensivists-summarizing-the-more-recent-advances-a-systematic-structured-review
#11
REVIEW
Patrick M Honore, Rita Jacobs, Olivier Joannes-Boyau, Jouke De Regt, Elisabeth De Waele, Viola van Gorp, Willem Boer, Lies Verfaillie, Herbert D Spapen
In recent years, after all the attention has been focused on the dose for continuous renal replacement therapy (CRRT) in sepsis and systemic inflammation response syndrome (SIRS), the relatively negative results of all those studies did urge our expectations on new approaches regarding CRRT in sepsis and SIRS. So far, after the failure of the major randomized studies on dose, attention is now drawn to new membranes that could better eliminate massive amounts of unbound mediators in wider spectrum and also in greater magnitude Nevertheless, for septic acute kidney injury, the recommended dose will remain 35 ml/kg/h until the IVOIRE (hIgh VOlume in Intensive Care) study will be published...
March 2013: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/22541787/evaluation-of-bactec-plus-aerobic-and-anaerobic-blood-culture-bottles-and-bact-alert-fan-aerobic-and-anaerobic-blood-culture-bottles-for-the-detection-of-bacteremia-in-icu-patients
#12
COMPARATIVE STUDY
Kyoung Ho Roh, Ju Yeon Kim, Ha Nui Kim, Hye Jin Lee, Jang Wook Sohn, Min Ja Kim, Yunjung Cho, Young Kee Kim, Chang Kyu Lee
Blood culture is the most valuable laboratory test for the diagnosis of bacteremia and sepsis. The BACTEC FX and BacT/Alert 3D automated blood culture systems are commonly used in Korean health care facilities. A controlled clinical evaluation of the resin-containing BACTEC Plus aerobic (BA) and anaerobic (BN), and the charcoal-containing FAN aerobic (FA) and anaerobic (FN) bottles using blood from intensive care unit (ICU) patients was designed. The performances of these 2 systems with media containing particle absorbing antimicrobial agents were evaluated using the culture positivity rate and time to detection (TTD)...
July 2012: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/22388838/-plasmapheresis-in-intensive-care
#13
Elena Mancini, Antonio Santoro
Blood purification by means of plasmapheresis has been known since the 1950s. Plasmapheresis first separates plasma from the blood's cell component; in the classical plasma exchange modality, the patient's plasma is then replaced with fresh frozen plasma from a donor. This procedure is still current in different fields of medicine, as there are hematological (thrombotic thrombocytopenic purpura, Waldenström's disease), neurological (Guillain-Barre' syndrome, myasthenia gravis) and toxicological indications (several forms of mushroom poisoning, tricyclic antidepressants, transfusional reactions), as well as nephrological indications (Goodpasture's syndrome, ANCA-associated vasculitis, myeloma) for its use...
January 2012: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/21865784/an69-evolution-of-the-world-s-first-high-permeability-membrane
#14
REVIEW
Michel Thomas, Kazuhiro Moriyama, Ingrid Ledebo
In response to a request from the French government, Rhône-Poulenc started development of a synthetic membrane for dialysis in 1969. When used for patients the new membrane, AN69, showed improved efficiency and clinical outcome. Treatment times could be reduced, peripheral neuropathy improved and patients expressed improved quality of life. This was the introduction of high-flux, volume-controlled dialysis. The polymer used for the AN69 membrane is a copolymer of acrylonitrile and sodium methallylsulfonate, specially selected for the dialysis application...
2011: Contributions to Nephrology
https://www.readbyqxmd.com/read/21118369/removal-of-humoral-mediators-and-the-effect-on-the-survival-of-septic-patients-by-hemoperfusion-with-neutral-microporous-resin-column
#15
RANDOMIZED CONTROLLED TRIAL
Zhao Huang, Si-Rong Wang, Wei Su, Ji-Yun Liu
The aim of this study is to evaluate the impact of neutral microporous resin hemoperfusion on hemodynamic improvement, removal of inflammatory cytokines, and mortality in critical care patients with severe sepsis. Forty-four patients with severe sepsis or septic shock were randomized to HA type hemoperfusion treatment (N=24) or standard therapy (N=20). Those undergoing hemoperfusion treatment received HA330 hemoperfusion. We measured the plasma concentrations of IL-6 and IL-8 at the start of every hemoperfusion treatment, and the following parameters were compared between the control group and the hemoperfusion group on days 3, 7, and 14: hemodynamics (cardiac index, systemic vascular resistance index, heart rate, and mean arterial pressure); change of hematology and coagulation function; organ function; and the sequential organ failure assessment (SOFA) score...
December 2010: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/20688297/guidelines-on-blood-cultures
#16
Michael Lloyd Towns, William Robert Jarvis, Po-Ren Hsueh
Just over one-third of sepsis patients have positive blood cultures, mainly due to inadequate sampling volumes (50% of adults have < 1.0 CFU/mL blood) and the prior use of antibiotics. However, 20-30% of sepsis patients are given inappropriate empirical antibiotics. The Clinical and Laboratory Standards Institute guidelines recommend paired culture sets to help discriminate between contaminant organisms and true pathogens; four 10-mL bottles (2 sets) should be used for the initial evaluation to detect about 90-95% of bacteremias and six 10-mL bottles (3 sets) should be used to detect about 95-99% of bacteremias...
August 2010: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/20064258/protective-effect-of-resin-adsorption-on-septic-plasma-induced-tubular-injury
#17
Vincenzo Cantaluppi, Viktoria Weber, Carola Lauritano, Federico Figliolini, Silvia Beltramo, Luigi Biancone, Massimo De Cal, Dinna Cruz, Claudio Ronco, Giuseppe Paolo Segoloni, Ciro Tetta, Giovanni Camussi
INTRODUCTION: A pro-apoptotic effect of circulating mediators on renal tubular epithelial cells has been involved in the pathogenesis of sepsis-associated acute kidney injury (AKI). Adsorption techniques have been showed to efficiently remove inflammatory cytokines from plasma. The aim of this study was to evaluate the efficiency of the hydrophobic resin Amberchrom CG161 M to adsorb from septic plasma soluble mediators involved in tubular injury. METHODS: We enrolled in the study 10 critically ill patients with sepsis-associated AKI and we evaluated the effects of their plasma on granulocyte adhesion, apoptosis and functional alterations of cultured human kidney tubular epithelial cells...
2010: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/20000104/-clinical-efficacy-of-the-biospecific-hemosorbent-liposorb
#18
COMPARATIVE STUDY
D V Vvedenskiĭ, V P Kirkovskiĭ, V N Gapanovich, A V Starostin, D A Makarevich
The aim of the present work was to evaluate clinical efficacy of the biospecific hemosorbent "Liposorb". The main component of "Liposorb" is polyacrylamide gel containing an immobilized affine ligand (antibiotic polymyxin E-colistyne). 40 patients with abdominal sepsis and peritonitis of different genesis underwent a total of 52 seances of vein-venous extracorporeal hemoperfusion of hemosorbent "Liposorb". Endotoxin level (lipopolysaccharide - LPS) was measured by the turbodimetric method. Blood perfusion through a "Liposorb" column at 50-70 ml/min during 90 minutes permitted to reach stabilization of parameters of systemic hemodynamics...
2009: Vestnik Rossiĭskoĭ Akademii Meditsinskikh Nauk
https://www.readbyqxmd.com/read/19523413/physical-properties-and-biological-activity-of-poly-butyl-acrylate-styrene-nanoparticle-emulsions-prepared-with-conventional-and-polymerizable-surfactants
#19
Julio C Garay-Jimenez, Danielle Gergeres, Ashley Young, Daniel V Lim, Edward Turos
UNLABELLED: Recent efforts in our laboratory have explored the use of polyacrylate nanoparticles in aqueous media as stable emulsions for potential applications in treating drug-resistant bacterial infections. These emulsions are made by emulsion polymerization of acrylated antibiotic compounds in a mixture of butyl acrylate and styrene (7:3 wt/wt) using sodium dodecyl sulfate as a surfactant. Prior work in our group established that the emulsions required purification to remove toxicity associated with extraneous surfactant present in the media...
December 2009: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/19203350/extraction-of-the-anti-sepsis-component-from-terminaliachebula-retz-and-evaluation-of-its-biological-activities
#20
Jie Yao, Jun Song Zheng, WeiLing Fu, Jiang Zheng
Many clinical experiments and studies have demonstrated that traditional Chinese medicines possess the capacity for being used in anti-sepsis. In this paper, we screened 78 herbs based on biosensor technology by targeting of lipid A. Terminaliachebula Retz was found to possess the highest capability of binding lipid A. With CER (cation-exchange resin) and HPLC, we obtained three active components extracted from Terminaliachebula Retz, and named them TCR1, TCR2 and TCR3 respectively. These three components were evaluated with the biosensor, and it was found that the TCR3 was the most capable candidate to bind lipid A...
February 2010: Bioscience Reports
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