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https://www.readbyqxmd.com/read/29774091/sensitive-molecular-detection-of-small-nodal-metastasis-in-uterine-cervical-cancer-using-hpv16-e6-ck19-muc1-cancer-biomarkers
#1
Vanessa Samouëlian, Nawel Mechtouf, Eric Leblanc, Guillaume B Cardin, Valérie Lhotellier, Denis Querleu, Françoise Révillion, Francis Rodier
Metastatic nodal involvement is a critical prognostic factor in uterine cervical cancer (UCC). To improve current methods of detecting UCC metastases in lymph nodes (LNs), we used quantitative PCR (qPCR) to assess mRNA expression of potential metastatic biomarkers. We found that expression of HPV16-E6, cytokeratin19 (CK19), and mucin1 (MUC1) is consistently upregulated in tumors and metastatic tissues, supporting a role for these genes in UCC progression. These putative biomarkers were able to predict the presence of histologically positive metastatic LNs with respective sensitivities and specificities of 82% and 99% (CK19), 76% and 95% (HPV16-E6), and 76% and 78% (MUC1)...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29771619/affordable-care-act-impact-in-kentucky-increasing-access-reducing-disparities
#2
Lynn A Blewett, Colin Planalp, Giovann Alarcon
OBJECTIVES: To examine health insurance disparities since Kentucky's implementation of the Affordable Care Act (ACA). METHODS: Using the American Community Survey, we estimated coverage rates by race/ethnicity before and after implementation of the ACA (2013 and 2015), and we estimated whether groups were over- or underrepresented among the uninsured, compared with their share of the state population. RESULTS: Kentucky's uninsurance rate declined from 14...
May 17, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29771612/state-indoor-tanning-laws-and-prevalence-of-indoor-tanning-among-us-high-school-students-2009-2015
#3
Jin Qin, Dawn M Holman, Sherry Everett Jones, Zahava Berkowitz, Gery P Guy
OBJECTIVES: To examine the association between state indoor tanning laws and indoor tanning behavior using nationally representative samples of US high school students younger than 18 years. METHODS: We combined data from the 2009, 2011, 2013, and 2015 national Youth Risk Behavior Surveys (n = 41 313) to analyze the association between 2 types of state indoor tanning laws (age restriction and parental permission) and the prevalence of indoor tanning during the 12 months before the survey, adjusting for age, race/ethnicity, and survey year, and stratified by gender...
May 17, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29769207/mitigating-sox2-potentiated-immune-escape-of-head-and-neck-squamous-cell-carcinoma-with-a-sting-inducing-nanosatellite-vaccine
#4
Yee Sun Tan, Kanokwan Sansanaphongpricha, Yuying Xie, Christopher R Donnelly, Xiaobo Luo, Blake R Heath, Xinyi Zhao, Emily L Bellile, Hongxiang Hu, Hongwei Chen, Peter J Polverini, Qianming Chen, Simon Young, Thomas E Carey, Jacques E Nör, Robert L Ferris, Gregory Wolf, Duxin Sun, Yu L Lei
PURPOSE: The response rates of Head and Neck Squamous Cell Carcinoma (HNSCC) to checkpoint blockade are below 20%. We aim to develop a mechanism-based vaccine to prevent HNSCC immune escape. EXPERIMENTAL DESIGN: We performed RNA-Seq of sensitive and resistant HNSCC cells to discover central pathways promoting resistance to immune killing. Using biochemistry, animal models, HNSCC microarray and immune cell deconvolution, we assessed the role of SOX2 in inhibiting STING-type I interferon (IFN-I) signaling-mediated anti-tumor immunity...
May 16, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29765906/epstein-barr-virus-and-human-papillomaviruses-interactions-and-their-roles-in-the-initiation-of-epithelial-mesenchymal-transition-and-cancer-progression
#5
REVIEW
Farhan S Cyprian, Halema F Al-Farsi, Semir Vranic, Saghir Akhtar, Ala-Eddin Al Moustafa
Oncoviruses are implicated in around 20% of all human cancers including both solid and non-solid malignancies. Epstein-Barr virus (EBV) and human papillomaviruses (HPVs) are the most common oncoviruses worldwide. Currently, it is well established that onco-proteins of EBV (LMP1, LMP2A, and EBNA1) and high-risk HPVs (E5 and E6/E7) play an important role in the initiation and/or progression of several human carcinomas, including cervical, oral, and breast. More significantly, it has been recently pointed out that viral onco-proteins of EBV and high-risk HPVs can be co-present and consequently cooperate to initiate and/or amplify epithelial-mesenchymal transition (EMT), which is the hallmark of cancer progression and metastasis...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29763715/near-infrared-light-activated-red-emitting-upconverting-nanoplatform-for-t-1-weighted-magnetic-resonance-imaging-and-photodynamic-therapy
#6
Xiang-Long Tang, Jun Wu, Ben-Lan Lin, Sheng Cui, Hong-Mei Liu, Ru-Tong Yu, Xiao-Dong Shen, Ting-Wei Wang, Wei Xia
Photodynamic therapy (PDT) has increasingly become an efficient and attractive cancer treatment modality based on reactive oxygen species (ROS) that can induce tumor death after irradiation with ultraviolet or visible light. Herein, to overcome the limited tissue penetration in traditional PDT, a novel near-infrared (NIR) light-activated NaScF4 : 40% Yb, 2% Er@CaF2 upconversion nanoparticle (rUCNP) is successfully designed and synthesized. Chlorin e6, a photosensitizer and a chelating agent for Mn2+ , is loaded into human serum albumin (HSA) that further conjugates onto rUCNPs...
May 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29762622/charge-switchable-nanocapsules-with-multistage-ph-responsive-behaviours-for-enhanced-tumour-targeted-chemo-photodynamic-therapy-guided-by-nir-mr-imaging
#7
Jia Zhou, Tianliang Li, Chunlei Zhang, Junyuan Xiao, Daxiang Cui, Yingsheng Cheng
Multifunctional nanoplatforms have been developed into advanced drug delivery systems for cancer therapy. In this study, we report a charge-switchable nanocapsule with multistage pH-responsive behaviors. First, DOX-encapsulated and oleylamine-embedded hollow structures with a diameter of 132 ± 21 nm are prepared via the double emulsion method. Subsequently, the hollow structures are encompassed by Gd-DTPA-, chlorin e6 (Ce6)-, and folate (FA)-modified BSA to form tumour-targeted, dual NIR/MR imaging-guided and chemo-photodynamic therapeutic nanoplatforms...
May 15, 2018: Nanoscale
https://www.readbyqxmd.com/read/29759030/development-of-human-derived-cell-culture-lines-for-recurrent-respiratory-papillomatosis
#8
James Attra, Li-En Hsieh, Linda Luo, Jun Qin Mo, Matthew Brigger, Yu-Tsueng Liu, Seth Pransky
Recurrent respiratory papillomatosis (RRP) is mainly caused by human papillomavirus (HPV) 6 and 11. While various adjuvant therapies have been reported, no effective therapy has been documented to universally "cure" this disease. In the era of precision medicine, it would be valuable to identify effective intervention based on drug sensitivity testing and/or molecular analysis. It is essential to be able to successfully carry out in vitro culture and expand tumor cells directly from patients to accomplish this goal...
May 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29756137/ros-responsive-mesoporous-silica-nanoparticles-for-mr-imaging-guided-photodynamically-maneuvered-chemotherapy
#9
Vijayakameswara Rao N, Hwa Seung Han, Hansang Lee, Van Quy Nguyen, Sangmin Jeon, Dae-Woong Jung, Jeongjin Lee, Gi-Ra Yi, Jae Hyung Park
Mesoporous silica nanoparticles (MSNs) with stimuli-responsive gatekeepers have been extensively investigated for controlled drug delivery at the target sites. Herein, we developed reactive oxygen species (ROS)-responsive MSNs (R-MSNs), consisting of a gadolinium (Gd)-DOTA complex as the ROS-responsive gatekeeper and polyethylene glycol (PEG)-conjugated chlorin e6 as the ROS generator, for magnetic resonance (MR) imaging-guided photodynamic chemotherapy. Doxorubicin (DOX), chosen as an anticancer drug, was physically encapsulated into DOTA-conjugated MSNs, followed by chemical crosslinking via the addition of GdCl3...
May 14, 2018: Nanoscale
https://www.readbyqxmd.com/read/29750306/microrna%C3%A2-195-inhibits-cell-proliferation-migration-and-invasion-by-targeting-defective-in-cullin-neddylation-1-domain-containing-1-in-cervical-cancer
#10
Jinyan Zhong, Hui Yuan, Xiangqian Xu, Shoufang Kong
MicroRNAs (miRs), a class of small non‑coding RNAs, have been demonstrated to perform promoting or suppressive roles in various types of human malignancy. Deregulation of miR‑195 has been observed in numerous types of human cancer, including cervical cancer; however, the detailed molecular mechanism of miR‑195 underlying the malignant progression of cervical cancer remains largely unclear. In the present study, miR‑195 was significantly downregulated in cervical cancer tissue samples compared with adjacent non‑tumor tissue samples, and the reduced expression level of miR‑195 was associated with node metastasis and an advanced clinical stage in cervical cancer...
May 8, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29749321/prevalence-of-the-integration-status-for-human-papillomavirus-16-in-esophageal-carcinoma-samples
#11
Shuying Li, Haie Shen, Ji Li, Xiaoli Hou, Ke Zhang, Jintao Li
BACKGROUND/AIMS: To investigate the etiology of esophageal cancer (EC) related with human papillomavirus (HPV) infection. MATERIALS AND METHODS: Fresh surgically resected tissue samples and clinical information were obtained from 189 patients. Genomic DNA was extracted, and HPV was detected using polymerase chain reaction (PCR) with HPV L1 gene primers of MY09/11; HPV16 was detected using HPV16 E6 type-specific primer sets. Copies of HPV16 E2, E6, and the human housekeeping gene β-actin were tested using quantitative PCR to analyze the relationship between HPV16 integration and esophageal squamous cell carcinoma and the relationship between the HPV16 integration status and clinical information of patients...
March 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29747434/the-impact-of-human-papilloma-viruses-matrix-metallo-proteinases-and-hiv-protease-inhibitors-on-the-onset-and-progression-of-uterine-cervix-epithelial-tumors-a-review-of-preclinical-and-clinical-studies
#12
REVIEW
Giovanni Barillari, Paolo Monini, Cecilia Sgadari, Barbara Ensoli
Infection of uterine cervix epithelial cells by the Human Papilloma Viruses (HPV) is associated with the development of dysplastic/hyperplastic lesions, termed cervical intraepithelial neoplasia (CIN). CIN lesions may regress, persist or progress to invasive cervical carcinoma (CC), a leading cause of death worldwide. CIN is particularly frequent and aggressive in women infected by both HPV and the Human Immunodeficiency Virus (HIV), as compared to the general female population. In these individuals, however, therapeutic regimens employing HIV protease inhibitors (HIV-PI) have reduced CIN incidence and/or clinical progression, shedding light on the mechanism(s) of its development...
May 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29743079/hiv-1-tat-expression-and-sulphamethoxazole-hydroxylamine-mediated-oxidative-stress-alter-the-disulfide-proteome-in-jurkat-t-cells
#13
Kemi Adeyanju, John R Bend, Michael J Rieder, Gregory A Dekaban
BACKGROUND: Adverse drug reactions (ADRs) are a significant problem for HIV patients, with the risk of developing ADRs increasing as the infection progresses to AIDS. However, the pathophysiology underlying ADRs remains unknown. Sulphamethoxazole (SMX) via its active metabolite SMX-hydroxlyamine, when used prophylactically for pneumocystis pneumonia in HIV-positive individuals, is responsible for a high incidence of ADRs. We previously demonstrated that the HIV infection and, more specifically, that the HIV-1 Tat protein can exacerbate SMX-HA-mediated ADRs...
May 9, 2018: Virology Journal
https://www.readbyqxmd.com/read/29742262/model-resin-composites-incorporating-zno-np-activity-against-s-mutans-and-physicochemical-properties-characterization
#14
Natasha Lamego Brandão, Maristela Barbosa Portela, Luciane Cople Maia, Andréa Antônio, Vanessa Loureiro Moreira E Silva, Eduardo Moreira da Silva
Although resin composites are widely used in the clinical practice, the development of recurrent caries at composite-tooth interface still remains as one of the principal shortcomings to be overcome in this field. Objectives To evaluate the activity against S. mutans biofilm of model resin composites incorporating different concentrations of ZnO-nanoparticles (ZnO-NP) and characterize their physicochemical properties. Materials and Methods Different concentrations of ZnO-NP (wt.%): E1=0, E2=0.5, E3=1, E4=2, E5=5 and E6=10 were incorporated into a model resin composite consisting of Bis-GMA-TEGDMA and barium borosilicate particles...
2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29741143/zinc-finger-nuclease-combines-with-cisplatin-and-trichostatin-a-enhances-the-antitumor-potency-in-cervical-cancer-cells
#15
Ci Ren, Hui Wang, Wencheng Ding, Chun Gao, Xiaomin Li, Hui Shen, Liming Wang, Da Zhu, Peng Wu, Ding Ma
Cervical cancer is the third-most common malignant tumor among women worldwide, which seriously endangers the life and health of Chinese women. The primary etiological factor of cervical cancer is persistent infection with high-risk human papillomavirus (HR-HPV), particularly HPV16 and HPV18. HR-HPV express oncoproteins E6 and E7, both of which play key roles in the progression of cervical carcinogenesis. Zinc Finger Nucleases (ZFNs) targeting HPVE7 induce specific shear of the E7 gene, weakening the malignant biological effects, hence showing great potential for clinical transformation...
May 9, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29739791/%C3%AE-np63%C3%AE-src-slug-signalling-axis-promotes-epithelial-to-mesenchymal-transition-in-squamous-cancers
#16
Kirtiman Srivastava, Adam Pickard, Stephanie G Craig, Gerard P Quinn, Shauna M Lambe, Jacqueline A James, Simon McDade, Dennis McCance
PURPOSE: To investigate the regulation of epithelial-to-mesenchymal transition (EMT) in  Head and Neck Squamous Cell Carcinoma (HNSCC) and its importance in tumour invasion. EXPERIMENTAL DESIGN: We use a 3D invasive organotypic raft culture model of human foreskin keratinocytes expressing the E6/E7 genes of the Human Papilloma Virus-16, coupled with bioinformatics and immunohistochemical analysis of patient samples to investigate  the role played by EMT in invasion and identify effectors and upstream regulatory pathways...
May 8, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29736316/hpv16-viral-load-and-physical-state-measurement-as-a-potential-immediate-triage-strategy-for-hr-hpv-infected-women-a-study-in-644-women-with-single-hpv16-infections
#17
Anna Manawapat-Klopfer, Lisa Wang, Juliane Haedicke-Jarboui, Frank Stubenrauch, Christian Munk, Louise T Thomsen, Peter Martus, Susanne K Kjaer, Thomas Iftner
High genome copy number (viral load) of human papillomavirus (HPV) is being discussed as a risk factor for high-grade cervical lesions. However, conflicting data about the integration status or viral load of the virus as risk factors for prevalent high-grade squamous intraepithelial lesions (HSIL) are found in the literature. To investigate whether viral load and/or integration status are indicative for prevalent ASCUS/LSIL or HSIL, we determined the HPV16 viral load and the physical state of the genome in 644 women with single HPV16 infections stratified by their cytology results from a large Danish population-based cohort consisting of 40,399 women...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29736315/kshv-co-infection-regulates-hpv16-cervical-cancer-cells-pathogenesis-in-vitro-and-in-vivo
#18
Lu Dai, Jing Qiao, Luis Del Valle, Zhiqiang Qin
High-risk human papillomavirus (HPV) infection is the etiological agent of cervical, oral and oropharyngeal cancers. Another oncogenic virus, Kaposi sarcoma-associated herpesvirus (KSHV) can cause several human cancers arising in those immunocompromised patients. KSHV DNA has been detected in the oral cavity and the female genital tract, although its detection rate in cervical samples is relatively low. Therefore, it remains unclear about the role of KSHV co-infection in the development of HPV-related neoplasia...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29733248/antitumor-response-by-endoplasmic-reticulum-targeting-dna-vaccine-is-improved-by-adding-a-kdel-retention-signal
#19
José J Pérez-Trujillo, Olivia A Robles-Rodríguez, Rodolfo Garza-Morales, Aracely García-García, Humberto Rodríguez-Rocha, Arnulfo Villanueva-Olivo, Juan C Segoviano-Ramírez, Sandra C Esparza-González, Odila Saucedo-Cárdenas, Roberto Montes-de-Oca-Luna, María J Loera-Arias
Directing an antigen to the endoplasmic reticulum (ER) improves the antigen-specific immune response, revealing a potentially useful strategy in cancer immunotherapy using tumor-associated antigens (TAAs). This can be achieved by fusing the antigen to an ER chaperone protein, such as calreticulin (CRT). We previously reported the antitumor response by fusing the CRT signal peptide (SP) and its ER retention sequence (KDEL) to full-length human papillomavirus type 16 (HPV-16) E6 and E7 antigens, obtaining a potent antitumoral effect...
May 7, 2018: Nucleic Acid Therapeutics
https://www.readbyqxmd.com/read/29731894/integration-sites-of-human-papillomavirus-18-in-esophageal-cancer-samples
#20
Shuying Li, Zhanjun Liu, Jianghong Yan, Shangbo Sun, Xiaoli Hou, Dianqing Liu, Ke Zhang, Jin-Tao Li
To investigate the association between human papillomavirus (HPV) infection and esophageal cancer, genomic DNA was isolated from 189 samples obtained from patients with esophageal carcinoma, and HPV DNA was identified using the polymerase chain reaction (PCR) with the following specific primers: My09/11 for HPV L1 and HPV18 E6 for HPV18. The HPV18 gene products were sequenced to identify the HPV genotype and the HPV18 integration site was verified using PCR amplification of papillomavirus oncogene transcripts...
May 2018: Oncology Letters
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