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https://www.readbyqxmd.com/read/28342729/repeatability-and-agreement-of-scheimpflug-based-and-swept-source-optical-biometry-measurements
#1
Saadettin Sel, Jana Stange, Delia Kaiser, Laszlo Kiraly
PURPOSE: To evaluate the repeatability and comparability of biometry parameters between a Scheimpflug-based topography with axial length measurement (Pentacam AXL, Oculus, Wetzlar, Germany) and a swept-source optical biometry (IOLMaster 700, Carl Zeiss Meditec AG, Jena, Germany). METHODS: A total of 50 eyes from 50 adult subjects had biometry measurements in one session three times using the Pentacam AXL and the IOLMaster 700. Keratometry, anterior chamber depth (ACD) and axial length (AL) values were obtained by both devices...
March 22, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28334506/molecular-features-of-the-yap-inhibitor-verteporfin-synthesis-of-hexasubstituted-dipyrrins-as-potential-inhibitors-of-yap-taz-the-downstream-effectors-of-the-hippo-pathway
#2
Floriane Gibault, Fabrice Bailly, Matthieu Corvaisier, Mathilde Coevoet, Guillemette Huet, Patricia Melnyk, Philippe Cotelle
Porphyrin derivatives, and in particular Verteporfin (VP), a photosensitizer initially designed for cancer therapy, have been identified as inhibitors of YAP-TEAD interaction and transcriptional activity. We herein report the efficient convergent synthesis of the dipyrrin western half-part of protoporphyrin IX dimethyl ester (PPIX-DME) where the sensitive vinyl group was created at the final stage by a dehydroiodation reaction. Two other dipyrrin derivatives were synthesized including dipyrrin 19 containing two vinyl groups...
March 23, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28333143/molecular-insights-of-gas6-tam-in-cancer-development-and-therapy
#3
REVIEW
Guiling Wu, Zhiqiang Ma, Wei Hu, Dongjin Wang, Bing Gong, Chongxi Fan, Shuai Jiang, Tian Li, Jianyuan Gao, Yang Yang
Since growth arrest-specific gene 6 (Gas6) was discovered in 1988, numerous studies have highlighted the role of the Gas6 protein and its receptors Tyro3, Axl and Mer (collectively referred to as TAM), in proliferation, apoptosis, efferocytosis, leukocyte migration, sequestration and platelet aggregation. Gas6 has a critical role in the development of multiple types of cancers, including pancreatic, prostate, oral, ovarian and renal cancers. Acute myelocytic leukaemia (AML) is a Gas6-dependent cancer, and Gas6 expression predicts poor prognosis in AML...
March 23, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28327411/gas6-axl-signaling-in-presence-of-sunitinib-is-enhanced-diversified-and-sustained-in-renal-tumor-cells-resulting-in-tumor-progressive-advantages
#4
Anna Gustafsson, Helena K M Fritz, Björn Dahlbäck
Clear Cell Renal Cell Carcinoma (CCRCC) is a lethal cancer with bad prognosis due to development of chemoresistance and recurrence of more aggressive tumors. Investigation of Gas6-mediated Axl signaling in CCRCC and endothelial cells reveals a Sunitinib resistant Gas6-Axl signaling that is sustained and enhanced and specifically triggers downstream AKT and PRAS40 activation in an intensified manner. Gas6-induced Axl signaling in presence of Sunitinib is also diversified displaying onset of Axl-dependent EGFR and METR activation and activation of classical MAPK pathways...
March 19, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28325774/erratum-expression-of-growth-arrest-specific-protein-6-and-axl-molecules-in-the-left-internal-mammary-artery-of-patients-undergoing-coronary-artery-bypass-grafting
#5
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28320530/single-cell-rna-sequence-analysis-of-mouse-glomerular-mesangial-cells-uncovers-mesangial-cell-essential-genes
#6
Yuqiu Lu, Yuting Ye, Qianqian Yang, Shaolin Shi
Mesangial cells are essential for the structure and function of glomeruli, but the mechanisms underlying these roles are not well understood. Here, we performed a single-cell RNA-sequence (RNA-seq) analysis of mouse mesangial cells using the Fluidigm C1 platform. We found that gene expression in individual mesangial cells was tremendously heterogeneous, with mean correlation coefficients of 0.20, and most mesangial genes were actually expressed in only a portion of mesangial cells and are therefore presumably dispensable...
March 17, 2017: Kidney International
https://www.readbyqxmd.com/read/28301380/nitroxoline-shows-antimyeloma-activity-by-targeting-the-trim25-p53-axle
#7
Hongwu Mao, Yanyun Du, Zubin Zhang, Biyin Cao, Jun Zhao, Haibin Zhou, Xinliang Mao
The aim of this study was to identify the most potent quinoline-based anti-infectives for the treatment of multiple myeloma (MM) and to understand the molecular mechanisms. A small-scale screen against a panel of marketed quinoline-based drugs was performed in MM cell lines. Cell apoptosis was examined by flow cytometry. Anti-MM activity was also evaluated in nude mice. Western blotting was performed to investigate mechanisms. Nitroxoline (NXQ) was the most effective in suppressing MM cell proliferation. NXQ induced more than 40% MM cell apoptosis within 24 h and potentiated anti-MM activities of current major drugs including doxorubicin and lenalidomide...
April 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28299982/oligo-ethylene-glycol-modified-%C3%AE-cyclodextrin-based-polyrotaxanes-for-simultaneously-modulating-solubility-and-cellular-internalization-efficiency
#8
Atsushi Tamura, Moe Ohashi, Nobuhiko Yui
We developed stimuli-labile polyrotaxanes (PRXs) composed of β-cyclodextrin (β-CD), Pluronic as an axle polymer, and acid-cleavable N-triphenylmethyl groups as bulky stopper molecules, and found that the PRXs are potent therapeutics for Niemann-Pick type C disease, because the PRX can effectively reduce intracellular cholesterol through the intracellular release of threaded β-CDs. In general, the PRXs need to be chemically modified with hydrophilic functional groups because PRXs are not soluble in aqueous media...
March 16, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28289089/molecular-pathways-oncologic-pathways-and-their-role-in-t-cell-exclusion-and-immune-evasion-a-new-role-for-the-axl-receptor-tyrosine-kinase
#9
Todd A Aguilera, Amato J Giaccia
With the clinical impact of CTLA-4 and PD-1/PD-L1 immune checkpoint therapies, widespread interest in cancer immunotherapy has been ignited. However, the rate and extent of clinical responses to approved therapies are limited and often non-existent in many solid tumors. This is partially because immune checkpoint therapies are most effective against T-cell inflamed tumors, and non-T-cell inflamed or T-cell excluded tumors remain a significant barrier. New strategies are needed to overcome immune resistance mechanisms that arise during tumor development which result in T-cell exclusion...
March 13, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28281680/human-endometrial-stromal-cells-are-highly-permissive-to-productive-infection-by-zika-virus
#10
Isabel Pagani, Silvia Ghezzi, Adele Ulisse, Alicia Rubio, Filippo Turrini, Elisabetta Garavaglia, Massimo Candiani, Concetta Castilletti, Giuseppe Ippolito, Guido Poli, Vania Broccoli, Paola Panina-Bordignon, Elisa Vicenzi
Zika virus (ZIKV) is a recently re-emerged flavivirus transmitted to humans by mosquito bites but also from mother to fetus and by sexual intercourse. We here show that primary human endometrial stromal cells (HESC) are highly permissive to ZIKV infection and support its in vitro replication. ZIKV envelope expression was detected in the endoplasmic reticulum whereas double-stranded viral RNA colocalized with vimentin filaments to the perinuclear region. ZIKV productive infection also occurred in the human T-HESC cell line together with the induction of interferon-β (IFN-β) and of IFN-stimulated genes...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28278008/the-influence-of-axle-position-and-the-use-of-accessories-on-the-activity-of-upper-limbs-muscles-during-manual-wheelchair-propulsion
#11
Guilherme da Silva Bertolaccini, Idinei Francisco Pires de Carvalho Filho, Gustavo Christofoletti, Luis Carlos Paschoarelli, Fausto Orsi Medola
INTRODUCTION: Wheelchair configuration is an important factor influencing the ergonomics of user-device interface and, from a biomechanical point of view, small changes in the chair setup may have a positive influence on the demand on the upper limbs during manual propulsion. This study aimed to investigate the influence of the position of the rear wheels' axle and the use of accessories on the activity of upper limb muscles during manual wheelchair propulsion. METHODS: Electromyography signal of the biceps, triceps, anterior deltoids and pectoralis major were collected with eleven able-bodied subjects in a wheelchair propulsion protocol with four different wheelchair configurations (differing in axle position and the use of accessories) in straightforward sprint and slalom course...
February 17, 2017: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/28275772/rapidly-accessible-click-rotaxanes-utilizing-a-single-amide-hydrogen-bond-templating-motif
#12
Beth E Fletcher, Michael J G Peach, Nicholas H Evans
The synthesis of hydrogen bond templated rotaxanes using the CuAAC click reaction has been achieved in yields of up to 47%, employing near stoichiometric equivalents of macrocycle and readily prepared azide and alkyne half-axle components. Interlocked structure formation has been confirmed by NMR spectroscopy and mass spectrometry. Density functional theory calculations support (1)H NMR spectroscopic analysis that the macrocycle resides over the amide of the axle component, rather than the newly formed triazole, as a result of more favourable hydrogen bond interactions...
March 9, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28272423/small-molecule-inhibitors-block-gas6-inducible-tam-activation-and-tumorigenicity
#13
Stanley G Kimani, Sushil Kumar, Nitu Bansal, Kamalendra Singh, Vladyslav Kholodovych, Thomas Comollo, Youyi Peng, Sergei V Kotenko, Stefan G Sarafianos, Joseph R Bertino, William J Welsh, Raymond B Birge
TAM receptors (Tyro-3, Axl, and Mertk) are a family of three homologous type I receptor tyrosine kinases that are implicated in several human malignancies. Overexpression of TAMs and their major ligand Growth arrest-specific factor 6 (Gas6) is associated with more aggressive staging of cancers, poorer predicted patient survival, acquired drug resistance and metastasis. Here we describe small molecule inhibitors (RU-301 and RU-302) that target the extracellular domain of Axl at the interface of the Ig-1 ectodomain of Axl and the Lg-1 of Gas6...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28270700/growth-arrest-specific-6-enhances-the-suppressive-function-of-cd4-cd25-regulatory-t-cells-mainly-through-axl-receptor
#14
Guang-Ju Zhao, Jia-Yi Zheng, Jia-Lan Bian, Long-Wang Chen, Ning Dong, Yan Yu, Guang-Liang Hong, Arvine Chandoo, Yong-Ming Yao, Zhong-Qiu Lu
Background. Growth arrest-specific (Gas) 6 is one of the endogenous ligands of TAM receptors (Tyro3, Axl, and Mertk), and its role as an immune modulator has been recently emphasized. Naturally occurring CD4(+)CD25(+) regulatory T cells (Tregs) are essential for the active suppression of autoimmunity. The present study was designed to investigate whether Tregs express TAM receptors and the potential role of Gas6-TAM signal in regulating the suppressive function of Tregs. Methods. The protein and mRNA levels of TAM receptors were determined by using Western blot, immunofluorescence, flow cytometry, and RT-PCR...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28263734/comparison-of-axial-length-corneal-and-anterior-chamber-depth-measurements-of-two-recently-introduced-devices-to-a-known-biometer
#15
Mehdi Shajari, Carla Cremonese, Kerstin Petermann, Pankaj Singh, Michael Müller, Thomas Kohnen
PURPOSE: Evaluate agreement and repeatability of axial length (AL), corneal curvature and anterior chamber depth (ACD) measurements of two new devices, one using Scheimpflug technology combined with partial coherence interferometry (Pentacam AXL from Oculus, Germany) and one using swept-source OCT (IOL Master 700 from Zeiss, Germany) to a widely-used optical biometer (IOL Master 500 from Zeiss, Germany). DESIGN: Prospective, instrument reliability analysis METHODS: Setting: Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany Study population: 79 eyes of 79 patients Study Procedure: All eyes were measured with the IOL Master 500, the IOL Master 700 and with the Pentacam AXL...
March 2, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28260071/axl-and-met-receptor-tyrosine-kinases-are-essential-for-lung-cancer-metastasis
#16
Yun Jung Choi, Ji Hye Kim, Jin Kyung Rho, Joong Sun Kim, Chang-Min Choi, Woo Sung Kim, Jaekyoung Son, Jae Cheol Lee
The AXL and MET receptors regulate key processes in tumor growth, metastasis, and drug resistance; thus, they have recently been implicated as promising therapeutic targets in various tumors. We investigated the metastatic potential and crosstalk between these receptors in non‑small cell lung cancer (NSCLC). We found that the treatment of NSCLC cells with hepatocyte growth factor (HGF) and growth arrest-specific 6 (Gas6), as ligands for MET and AXL, respectively, promoted their migration and invasion ability...
March 1, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28258690/tam-receptor-tyrosine-kinases-as-emerging-targets-of-innate-immune-checkpoint-blockade-for-cancer-therapy
#17
REVIEW
Yemsratch T Akalu, Carla V Rothlin, Sourav Ghosh
Cancer immunotherapy utilizing T-cell checkpoint inhibitors has shown tremendous clinical success. Yet, this mode of treatment is effective in only a subset of patients. Unresponsive patients tend to have non-T-cell-inflamed tumors that lack markers associated with the activation of adaptive anti-tumor immune responses. Notably, elimination of cancer cells by T cells is critically dependent on the optimal activity of innate immune cells. Therefore, identifying new targets that regulate innate immune cell function and promote the engagement of adaptive tumoricidal responses is likely to lead to the development of improved therapies against cancer...
March 2017: Immunological Reviews
https://www.readbyqxmd.com/read/28251492/key-roles-of-axl-and-mer-receptor-tyrosine-kinases-in-resistance-to-multiple-anticancer-therapies
#18
REVIEW
Marie Schoumacher, Mike Burbridge
A major challenge in anticancer treatment is the pre-existence or emergence of resistance to therapy. AXL and MER are two members of the TAM (TYRO3-AXL-MER) family of receptor tyrosine kinases, which, when activated, can regulate tumor cell survival, proliferation, migration and invasion, angiogenesis, and tumor-host interactions. An increasing body of evidence strongly suggests that these receptors play major roles in resistance to targeted therapies and conventional cytotoxic agents. Multiple resistance mechanisms exist, including the direct and indirect crosstalk of AXL and MER with other receptors and the activation of feedback loops regulating AXL and MER expression and activity...
March 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28249155/pharmacologic-targeting-of-s6k1-in-pten-deficient-neoplasia
#19
Hongqi Liu, Xizhi Feng, Kelli N Ennis, Catherine A Behrmann, Pranjal Sarma, Tony T Jiang, Satoshi Kofuji, Liang Niu, Yiwen Stratton, Hala Elnakat Thomas, Sang-Oh Yoon, Atsuo T Sasaki, David R Plas
Genetic S6K1 inactivation can induce apoptosis in PTEN-deficient cells. We analyzed the therapeutic potential of S6K1 inhibitors in PTEN-deficient T cell leukemia and glioblastoma. Results revealed that the S6K1 inhibitor LY-2779964 was relatively ineffective as a single agent, while S6K1-targeting AD80 induced cytotoxicity selectively in PTEN-deficient cells. In vivo, AD80 rescued 50% of mice transplanted with PTEN-deficient leukemia cells. Cells surviving LY-2779964 treatment exhibited inhibitor-induced S6K1 phosphorylation due to increased mTOR-S6K1 co-association, which primed the rapid recovery of S6K1 signaling...
February 28, 2017: Cell Reports
https://www.readbyqxmd.com/read/28247252/cabozantinib-an-active-novel-multikinase-inhibitor-in-renal-cell-carcinoma
#20
REVIEW
Nizar M Tannir, Gisela Schwab, Viktor Grünwald
Clear cell renal cell carcinoma (RCC) is characterized by inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene. VHL loss drives tumor angiogenesis and accounts for the clinical activity of VEGF receptor (VEGFR) tyrosine kinase inhibitors (TKIs), the first-line standard of care for advanced RCC. Within the last year, three new second-line treatments have received FDA approval for use after anti-angiogenic therapy: the immune checkpoint inhibitor nivolumab, the TKI cabozantinib, and the combination of the TKI lenvatinib and the mTOR inhibitor everolimus...
February 2017: Current Oncology Reports
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