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Prolonged pregnancy

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https://www.readbyqxmd.com/read/28075190/gestational-age-within-normal-range-and-infants-health-and-temperament-at-3-months-of-age
#1
Marsha Kaitz, David Mankuta, Ann Marie Rokem, Stephen V Faraone
OBJECTIVE: To examine the association between gestational age (GA) at birth across the normal GA spectrum (37-41 weeks) and the temperament and health of 3-month old infants. METHODS: The sample comprised 242 "low-risk" mothers and infants without chronic illnesses or severe pregnancy complications. Infant temperament was defined by three constructs: Negative Affectivity (NA), Extraversion, and Regulation, assessed by parents' reports on the Infant Behavior Questionnaire...
January 11, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28070660/treatment-options-for-hyperemesis-gravidarum
#2
REVIEW
Amy Abramowitz, Emily S Miller, Katherine L Wisner
Hyperemesis gravidarum (HG) is a severe and prolonged form of nausea and/or vomiting during pregnancy. HG affects 0.3-2% of pregnancies and is defined by dehydration, ketonuria, and more than 5% body weight loss. Initial pharmacologic treatment for HG includes a combination of doxylamine and pyridoxine. Additional interventions include ondansetron or dopamine antagonists such as metoclopramide or promethazine. The options are limited for women who are not adequately treated with these medications. We suggest that mirtazapine is a useful drug in this context and its efficacy has been described in case studies...
January 9, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28068594/prevention-of-spontaneous-preterm-birth-guidelines-for-clinical-practice-from-the-french-college-of-gynaecologists-and-obstetricians-cngof
#3
REVIEW
Loïc Sentilhes, Marie-Victoire Sénat, Pierre-Yves Ancel, Elie Azria, Guillaume Benoist, Julie Blanc, Gilles Brabant, Florence Bretelle, Stéphanie Brun, Muriel Doret, Chantal Ducroux-Schouwey, Anne Evrard, Gilles Kayem, Emeline Maisonneuve, Louis Marcellin, Stéphane Marret, Nicolas Mottet, Sabine Paysant, Didier Riethmuller, Patrick Rozenberg, Thomas Schmitz, Héloïse Torchin, Bruno Langer
In France, 60,000 neonates are born preterm every year (7.4%), half of them after the spontaneous onset of labor. Among preventable risk factors of spontaneous prematurity, only cessation of smoking is associated with decreased prematurity (level of evidence [LE]1). It is therefore recommended (Grade A). Routine screening and treatment of vaginal bacteriosis is not recommended in the general population (Grade A). The only population for which vaginal progesterone is recommended is that comprising asymptomatic women with singleton pregnancies, no history of preterm delivery, and a short cervix at 16-24 weeks of gestation (Grade B)...
December 30, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28056994/hexokinase-2-drives-glycogen-accumulation-in-equine-endometrium-at-day-12-of-diestrus-and-pregnancy
#4
Sarah A Bramer, Alysson Macedo, Claudia Klein
BACKGROUND: Secretion of histotroph during the prolonged pre-implantation phase in mares is crucial to pregnancy maintenance, manifested as increased embryonic loss in mares with age-related endometrial degeneration. Glycogen content of uterine histotroph is higher during the progesterone-dominated phase of the estrous cycle in mares, but regulatory mechanisms are not well understood. METHODS: mRNA expression of glycogen-metabolizing enzymes (HK1, HK2, GSK3B, GYS1, PEPCK, PKM, PYGM) in endometrial samples were compared among mares in anestrus, estrus, and at Day 12 of diestrus and pregnancy...
January 5, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28054353/factors-related-to-pregnancy-and-birth-and-the-risk-of-childhood-brain-tumours-the-estelle-and-escale-studies-sfce-france
#5
Helen D Bailey, Paula Rios, Brigitte Lacour, Lea Guerrini-Rousseau, Anne-Isabelle Bertozzi, Pierre Leblond, Cécile Faure-Conter, Isabelle Pellier, Claire Freycon, Jean Michon, Stéphanie Puget, Stéphane Ducassou, Laurent Orsi, Jacqueline Clavel
Little is known of the causes of childhood brain tumors (CBT). The aims of this study were to investigate whether extremes of birth weight were associated with increased risk of CBT and whether maternal pre-conceptional folic acid supplementation or breastfeeding reduced the risk. In addition, other maternal characteristics and birth related factors were also investigated. We pooled data from two French national population-based case-control studies with similar designs conducted in 2003-2004 and 2010-2011...
January 5, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28044045/recrudescence-of-plasmodium-falciparum-in-a-primigravida-after-nearly-3-years-of-latency
#6
Ahmed Al Hammadi, Michael Mitchell, George M Abraham, Jennifer P Wang
We present a case of a primigravid woman who presented with Plasmodium falciparum nearly 3 years after she last visited a malaria-endemic region. We review the literature to identify case reports of recrudescent P falciparum malaria during pregnancy, including those with prolonged latency. Reports of recrudescence of P falciparum during pregnancy are limited. Plasmodium falciparum infection can persist for years. Recrudescence can occur with waning of immunity following departure from endemic areas. Pregnancy, particularly the primigravid state, is a risk factor for severe infection...
January 2, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28029463/-tocolysis-for-preterm-labor-without-premature-preterm-rupture-of-membranes
#7
M Doret, G Kayem
OBJECTIVES: To propose guidelines for clinical practice for tocolysis in preterm labor without premature preterm rupture of the membranes (PPROM). MATERIALS AND METHODS: Bibliographic searches were performed in the Medline and Cochrane databases and gynecologist and obstetricians' international society guidelines. It is important to note that most studies included women in preterm labour with and without PPROM. RESULTS: Compared with placebo, tocolytics are not associated with a reduction in neonatal mortality or morbidity (LE2)...
October 28, 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/28018878/regulatory-approval-time-for-hormonal-contraception-in-canada-the-united-states-and-the-united-kingdom-2000-2015-a-retrospective-data-analysis
#8
Christine Troskie, Judith A Soon, Arianne Y Albert, Wendy V Norman
BACKGROUND: Access to a wide range of contraceptive methods improves prevention of unintended pregnancy by ensuring the best method fit for each individual. We compared approval times of new hormonal contraceptives by Health Canada, the US Food and Drug Administration (FDA), and the UK Medicines and Healthcare Products Regulatory Agency (MHRA). METHODS: We obtained dates of applications to Health Canada, the FDA and the MHRA for contraceptive methods approved from January 2000 to January 2015...
October 2016: CMAJ Open
https://www.readbyqxmd.com/read/28018155/neonatal-toxicity-from-escitalopram-use-in-utero-a-case-report
#9
Jessica Degiacomo, Sherry Luedtke
Selective serotonin reuptake inhibitor (SSRI) exposure during pregnancy can result in symptoms of serotonin syndrome or serotonin withdrawal. In contrast to other SSRIs, reports of serotonin behavioral syndrome following in utero exposure to escitalopram and citalopram are limited. We describe a case of suspected toxicity following in utero exposure to 20 mg escitalopram throughout pregnancy. The infant was transferred to our neonatal intensive unit at 9 hours of life for further evaluation of lethargy, weak cry, bradycardia, and non-reactive pupils...
November 2016: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/28012453/the-effect-of-histone-deacetylase-inhibition-on-the-expression-of-p-glycoprotein-in-human-placental-trophoblast-cell-lines
#10
Hongyu Duan, Chuan Wang, Kaiyu Zhou, Tao Wang, Yifei Li, Dajian Qiu, Qiang Li, Yi Zhang, Yimin Hua
INTRODUCTIONS: Placental P-glycoprotein (P-gp), encoded by ABCB1 gene in human, plays a significant role in regulating drugs' transplacental transfer rates. Investigations on placental P-gp regulation could provide more therapeutic targets for individualized and safe pharmacotherapy during pregnancy. Currently, the epigenetic control of placental P-gp is rare. This study aimed to investigate the effect of histone deacetylases (HDACs) inhibition on P-gp expression in placental trophoblast cell lines and to explore whether HDAC1/2/3 was involved in this process preliminarily...
January 2017: Placenta
https://www.readbyqxmd.com/read/28009618/electroconvulsive-therapy-considerations-for-transgendered-patients
#11
Billy K Tran, Stephen E O'Donnell, Agnes Balla, David C Adams, Lydia S Grondin, Mitchell H Tsai
As the transgender patient population continues to grow, health care providers will need to become aware of elements unique to the transgender community in order to provide the highest quality of care. Neuromuscular blockade with succinylcholine is routinely administered to patients undergoing electroconvulsive therapy (ECT). Decreased amounts or activity of pseudocholinesterase in serum can lead to prolonged duration of muscle paralysis. Causes of reduced action by pseudocholinesterase include genetically abnormal enzymes, reduced hepatic production, pregnancy, and various drug interactions...
December 21, 2016: Journal of ECT
https://www.readbyqxmd.com/read/28007010/genetic-analysis-of-a-hereditary-factor-xii-deficiency-pedigree-of-a-consanguineous-marriage-due-to-a-homozygous-f12-gene-mutation-gly341arg
#12
Xiaoli Cheng, Lihong Yang, Guoyong Huang, Yanhui Jin, Xiuping Hao, Mingshan Wang
OBJECTIVE AND IMPORTANCE: To study the gene mutations of factor XII (FXII) in a Chinese family of consanguineous marriage with FXII deficiency and illuminate the possible molecular pathogenic mechanism. It will contribute to our comprehension of the pathogenesis of the disease. CLINICAL PRESENTATION: The proband was a 26-year-old Chinese pregnant woman who was discovered, in a pregnancy test, with a prolonged activated partial thromboplastin time (APTT) at 61.6s (reference range, 29...
December 22, 2016: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28002532/stillbirth-in-dichorionic-twins-discordant-for-major-and-minor-anomaly-followed-by-asynchronous-delivery-a-rare-occurrence-case-presentation
#13
George Lucian Zorilă, Marius Cristian Marinaş, Maria Florea, Ciprian LaurenŢiu Pătru, Roxana Cristina Drăguşin, Răzvan Grigoraş Căpitănescu, Marian Valentin Zorilă, Roxana Eugenia Zăvoi, Cristiana Eugenia Simionescu, Dominic Gabriel Iliescu, Ştefania Tudorache
The single stillbirth long-term intrauterine retention in dichorionic twin pregnancy is rarely reported. Also, the birth of a fetus is followed in most cases by immediate expulsion of the second twin. We hereby present an unusual case of asynchronous delivery of dichorionic twins, associating discordance for major and minor anomaly. The intrauterine death of the twin A, presenting a large sacrococcygeal tumor, occurred in the second trimester. The deceased twin A was born at 29 weeks' gestational age (GA). The twin B was extracted by Caesarean section at 31 weeks and had a good outcome...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28002529/delayed-interval-delivery-in-twin-pregnancy-case-reports
#14
Constantin Cristian Văduva, Carmen Constantinescu, Mihaela Ţenovici, Alice Roxana Văduva, Mihaela Niculescu, Damian DiŢescu, Cristina CrenguŢa Albu, Dinu Florin Albu
The implementation of assisted reproduction has increased the incidence of multiple pregnancies. Prenatal death of one fetus in the second trimester of twin pregnancy confronts the obstetrician with a difficult problem with regard to the management of pregnancy. The scarcity of the condition and the absence of the large-scale studies make it difficult to advise the parents on the prognosis and optimal management. The unavoidable birth or death of one premature neonate has led to the aim of delayed interval delivery for the other twin...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27997333/presence-and-persistence-of-zika-virus-rna-in-semen-united-kingdom-2016
#15
Barry Atkinson, Fiona Thorburn, Christina Petridou, Daniel Bailey, Roger Hewson, Andrew J H Simpson, Timothy J G Brooks, Emma J Aarons
Zika virus RNA has been detected in semen collected several months after onset of symptoms of infection. Given the potential for sexual transmission of Zika virus and for serious fetal abnormalities resulting from infection during pregnancy, information regarding the persistence of Zika virus in semen is critical for advancing our understanding of potential risks. We tested serial semen samples from symptomatic male patients in the United Kingdom who had a diagnosis of imported Zika virus infection. Among the initial semen samples from 23 patients, Zika virus RNA was detected at high levels in 13 (56...
April 15, 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27988438/detection-of-lupus-anticoagulant-in-the-era-of-direct-oral-anticoagulants
#16
REVIEW
Ariela Hoxha, Alessandra Banzato, Amelia Ruffatti, Vittorio Pengo
Lupus anticoagulant (LAC) is an in vitro phenomenon determining a phospholipid-dependent elongation of clotting times. The presence of LAC associated with anticardiolipin (aCL) and anti-β2 glycoprotein I (anti-β2GPI) antibodies is strongly associated with thrombosis and pregnancy morbidity. Direct oral anticoagulants (DOACs) targeting thrombin and factor Xa are currently widely use to prevent and treat venous and arterial thromboembolism. Some concern has, however, been expressed about the possibility of false laboratory results during LAC assessment in patients taking these drugs...
December 15, 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27981742/maternal-and-neonatal-outcomes-of-pregnancies-in-women-with-addison-s-disease-a-population-based-cohort-study-on-7-7-million-births
#17
M Schneiderman, N Czuzoj-Shulman, A R Spence, H A Abenhaim
OBJECTIVE: To assess if pregnancies among women with Addison's disease (AD) are at higher risk of adverse maternal and neonatal outcomes. DESIGN: Population-based retrospective cohort study. SETTING/POPULATION: All births in the United States' Healthcare Cost and Utilization Project-Nationwide Inpatient Sample from 2003 to 2011. METHODS: Baseline characteristics were compared between women with AD and those without, and prevalence over time was measured...
December 15, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27974918/cervical-cerclage-in-advanced-prolapsed-fetal-membranes-case-presentation
#18
REVIEW
C F Tufan, R E Bohîlţea, A Tufan, A Marinescu, A Baros, M M Cîrstoiu
The case presentation of a transvaginal cervical cerclage performed at a 7 cm dilation in a patient in the 22nd week of pregnancy, followed by a prolongation of the pregnancy until the gestational age of 38 weeks, was reported in the context of many similar cases managed by the authors of the article during a program of screening and prevention of preterm birth. The particularity of the case was the lack of a preterm birth in the medical history of the patient and the installation of the isthmus-cervix incompetence in the second pregnancy, after an on term pregnancy...
January 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27959695/prolonged-zika-virus-viremia-during-pregnancy
#19
LETTER
Anna Suy, Elena Sulleiro, Carlota Rodó, Élida Vázquez, Cristina Bocanegra, Israel Molina, Juliana Esperalba, María P Sánchez-Seco, Hector Boix, Tomás Pumarola, Elena Carreras
No abstract text is available yet for this article.
29, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27959327/the-evolution-of-sex-specific-virulence-in-infectious-diseases
#20
Francisco Úbeda, Vincent A A Jansen
Fatality rates of infectious diseases are often higher in men than women. Although this difference is often attributed to a stronger immune response in women, we show that differences in the transmission routes that the sexes provide can result in evolution favouring pathogens with sex-specific virulence. Because women can transmit pathogens during pregnancy, birth or breast-feeding, pathogens adapt, evolving lower virulence in women. This can resolve the long-standing puzzle on progression from Human T-cell Lymphotropic Virus Type 1 (HTLV-1) infection to lethal Adult T-cell Leukaemia (ATL); a progression that is more likely in Japanese men than women, while it is equally likely in Caribbean women and men...
December 13, 2016: Nature Communications
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