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https://www.readbyqxmd.com/read/29470267/pregnancy-after-solid-organ-transplantation
#1
Jane M Kurz
PURPOSE: To explore the reproductive decision-making process with women who were organ transplant recipients (renal, lung, & heart transplants). STUDY DESIGN AND METHODS: Grounded theory guided data collection and analyses. Mixed methods with audiotaped telephone interviews and a written survey measuring social support were used. As social support is critical for women who are organ transplant recipients considering pregnancy, a search for disconfirming evidence for social support via a survey and interviews was included...
March 2018: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/29467921/endoplasmic-reticulum-stress-stimulates-the-release-of-extracellular-vesicles-carrying-danger-associated-molecular-pattern-damp-molecules
#2
Gavin P Collett, Christopher W Redman, Ian L Sargent, Manu Vatish
Disturbances in endoplasmic reticulum (ER) function lead to ER stress which, when severe or prolonged, may result in apoptosis. Severe ER stress has been implicated in several pathological conditions including pre-eclampsia, a multisystem disorder of pregnancy associated with the release of pro-inflammatory factors from the placenta into the maternal circulation. Here, we show that severe ER stress induced by two distinct mechanisms in BeWo choriocarcinoma cells leads to the release of extracellular vesicles (EVs) carrying pro-inflammatory damage-associated molecular pattern (DAMP) molecules...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29467407/maternal-obesity-induced-decreases-in-plasma-hepatic-and-uterine-polyunsaturated-fatty-acids-during-labour-is-reversed-through-improved-nutrition-at-conception
#3
Ronan Muir, Ge Liu, Raheela Khan, Anatoly Shmygol, Siobhan Quenby, Robert Alan Gibson, Beverly Muhlhausler, Matthew Elmes
Maternal obesity is associated with prolonged and dysfunctional labour, potentially through decreased synthesis of prostaglandins that stimulate myometrial contractions. We assessed the impact of maternal obesity on concentrations of precursor fatty acids (FA) for prostaglandin synthesis and whether any changes could be reversed by improved nutrition post-conception. Wistar rats were fed control (CON) or High-Fat, High-cholesterol (HFHC) diets 6 weeks before mating. At conception half the dams switched diets providing 4 dietary groups: (1) CON, (2) HFHC, (3) CON-HFHC or (4) HFHC-CON...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453927/effect-of-prenatal-recommendations-of-traditional-persian-medicine-on-obstetric-outcomes-a-randomized-clinical-trial
#4
Mansoor Keshavarz, Maryam Kashanian, Soodabeh Bioos, Yasaman Vazani
wufjhjdkf Background Traditional Persian Medicine (TPM) is an ancient medical system that provides suggestions to improve the health of mothers and children during pregnancy and labor. Persian physicians believed that these instructions made labor easier, safer, and less painful. Methods The present randomized clinical trial was conducted among women at 33-38 weeks of pregnancy in Tehran, Iran. TPM instructions consisted of diet, bathing, and application of oil from the 38th week of pregnancy to the onset of labor...
February 17, 2018: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29444779/estimating-the-met-need-for-emergency-obstetric-care-emoc-services-in-three-payams-of-torit-county-south-sudan-a-facility-based-retrospective-cross-sectional-study
#5
Pontius Bayo, Imose Itua, Suzie Paul Francis, Kofi Boateng, Elijo Omoro Tahir, Abdulmumini Usman
OBJECTIVE: To determine the met need for emergency obstetric care (EmOC) services in three Payams of Torit County, South Sudan in 2015 and to determine the frequency of each major obstetric complication. DESIGN: This was a retrospective cross-sectional study. SETTING: Four primary healthcare centres (PHCCs) and one state hospital in three payams (administrative areas that form a county) in Torit County, South Sudan. PARTICIPANTS: All admissions in the obstetrics and gynaecology wards (a total of 2466 patient admission files) in 2015 in all the facilities designated to conduct deliveries in the study area were reviewed to identify obstetric complications...
February 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29439618/effect-of-prolonged-gnrh-agonist-downregulation-on-icsi-outcome-in-patients-with-endometriomas-of-less-than-5-cm-a-randomized-controlled-trial
#6
Ahmed Mohamed Maged, Hamsa Rashwan, Maryam Mahmoud, Akmal El-Mazny, Mona Farouk, Doaa S Belal, Heba M Marie
OBJECTIVE: To evaluate the effect of prolonged Gonadotropin releasing hormone (GnRH) agonist downregulation in patients with endometriomas of less than 5 cm on the outcome of the proceeding Intracytoplasmic sperm injection (ICSI) trial. METHODS: In a randomized controlled trial at a university teaching hospital, 90 patients indicated for ICSI and having unilateral single endometrioma of less than 5 cm in diameter were randomized into 2 groups. Group A (45 patients) received the standard long protocol; whereas group B (45 patients) received 3 consecutive Intramuscular (IM) injections of triptorelin 3...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29437933/well-appearing-newborn-with-a-vesiculobullous-rash-at-birth
#7
Sarah E Stewart, Jody L Lin, Jennifer L Everhart, Trung H Pham, Ann L Marqueling, Kerri E Rieger, Sarah L Hilgenberg
A term, appropriate-for-gestational-age, male infant born via normal spontaneous vaginal delivery presented at birth with a full-body erythematous, vesiculobullous rash. He was well-appearing with normal vital signs and hypoglycemia that quickly resolved. His father had a history of herpes labialis. His mother had an episode of herpes zoster during pregnancy and a prolonged rupture of membranes that was adequately treated. The patient underwent a sepsis workup, including 2 attempted but unsuccessful lumbar punctures, and was started on broad-spectrum antibiotics and acyclovir, given concerns about bacterial or viral infection...
February 6, 2018: Pediatrics
https://www.readbyqxmd.com/read/29436197/the-role-of-serotonin-in-ventricular-repolarization-in-pregnant-mice
#8
Shanyu Cui, Hyewon Park, Hyelim Park, Dasom Mun, Seung Hyun Lee, Hyoeun Kim, Nuri Yun, Hail Kim, Michael Kim, Hui Nam Pak, Moon Hyoung Lee, Boyoung Joung
PURPOSE: The mechanisms underlying repolarization abnormalities during pregnancy are not fully understood. Although maternal serotonin (5-hydroxytryptamine, 5-HT) production is an important determinant for normal fetal development in mice, its role in mothers remains unclear. We evaluated the role of serotonin in ventricular repolarization in mice hearts via 5Htr3 receptor (Htr3a) and investigated the mechanism of QT-prolongation during pregnancy. MATERIALS AND METHODS: We measured current amplitudes and the expression levels of voltage-gated K⁺ (Kv) channels in freshly-isolated left ventricular myocytes from wild-type non-pregnant (WT-NP), late-pregnant (WT-LP), and non-pregnant Htr3a homozygous knockout mice (Htr3a(-/-)-NP)...
March 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29430983/c-reactive-protein-and-white-blood-cell-count-as-predictors-of-maternal-and-neonatal-infections-in-prelabour-rupture-of-membranes-between-34-and-41-weeks-of-gestation
#9
Manisha Rewatkar, Shuchi Jain, Manish Jain, Kanchan Mohod
Prelabour rupture of the membranes (PLROM) is defined as rupture of membranes before the onset of labour. It is one of the most common clinical events, where pregnancy can turn into a high-risk situation for mother and foetus. As prevention of PLROM is difficult, one has to concentrate on management to reduce its complications. Accurate prediction of infection remains a main challenge in cases of PLROM. We conducted a prospective study of all women admitted for PLROM at or after 34-41 weeks of gestation to investigate the predictive value of C-reactive protein (CRP) and white blood cell (WBC) count for early-onset neonatal infection (EONI) and maternal chorioamnionitis...
February 12, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29428703/the-contribution-of-total-and-free-iodothyronines-to-welfare-maintenance-and-management-stress-coping-in-ruminants-and-equines-physiological-ranges-and-reference-values
#10
REVIEW
Adriana Ferlazzo, Cristina Cravana, Esterina Fazio, Pietro Medica
In order to acquire a pattern of thyroid involvement in welfare maintenance in Ruminants and Equines, this review summarizes data concerning the reference values of total and free iodothyronines and their modifications in physiological conditions and in different management conditions (pregnancy, lactation, weaning, growth, isolation, restraint, shearing, confinement and transportation). Thyroidal and extrathyroidal tissues efficiently respond to management practices, giving a differentiated contribution to circulating iodothyronine changes...
February 2, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29415681/prenatal-and-perinatal-risks-for-late-language-emergence-in-a-population-level-sample-of-twins-at-age-2
#11
Catherine L Taylor, Mabel L Rice, Daniel Christensen, Eve Blair, Stephen R Zubrick
BACKGROUND: Late Language Emergence (LLE) in the first two years of life is one of the most common parental concerns about child development and reasons for seeking advice from health professionals. LLE is much more prevalent in twins (38%) than singletons (20%). In studies of language development in twins without overt disability, adverse prenatal and perinatal environments have been reported to play a lesser role in the etiology of LLE than adverse postnatal environments. However, there is a lack of population-level evidence about prenatal and perinatal risk factors for LLE in twins...
February 7, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29408744/the-use-of-antenatal-fetal-magnetic-resonance-imaging-in-the-assessment-of-patients-at-high-risk-of-preterm-birth
#12
REVIEW
L Story, J Hutter, T Zhang, A H Shennan, M Rutherford
Preterm birth, defined as birth occurring prior to 37 weeks gestation is a common obstetric complication affecting 8% of pregnancies and is associated with significant morbidity and mortality. Infection/inflammation has been implicated in both the aetiology of preterm birth itself and associated neonatal pulmonary and neurological morbidity. Treatment options are currently limited to prolongation of the pregnancy using cervical cerclage, pessaries or progesterone or administration of drugs including steroids to promote lung maturity and neuroprotective agents such as magnesium sulphate, the timing of which are highly critical...
March 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29407821/a-human-exposure-based-mixture-of-persistent-organic-pollutants-affects-the-stress-response-in-female-mice-and-their-offspring
#13
Alexandra M Hudecova, Kristine E A Hansen, Siddhartha Mandal, Hanne F Berntsen, Abdolrahman Khezri, Tracy L Bale, Thomas W K Fraser, Karin E Zimmer, Erik Ropstad
Persistent organic pollutants (POPs) are found in the food chain of both humans and animals and exert a wide spectrum of potentially adverse effects. The present experiment aimed to investigate whether a defined mixture of 29 POPs, based on the dietary intake of Scandinavians, could affect the stress response in female mice exposed through ingestion, and in their offspring. Female mice 129:C57BL/6F0 hybrids were exposed from weaning, throughout pregnancy, and up until necropsy, to either 5000 × or 100 000 × the estimated daily intake for Scandinavians...
January 18, 2018: Chemosphere
https://www.readbyqxmd.com/read/29404740/early-and-late-pregnancy-outcomes-in-women-treated-with-cold-coagulation-versus-lletz-cervical-treatment-for-cervical-intraepithelial-neoplasia-a-retrospective-cohort-study
#14
Dimitrios Papoutsis, Martyn Underwood, William Parry-Smith, Jane Panikkar
PURPOSE: To compare the pregnancy outcomes between women who were treated with cold-coagulation versus large loop excision of the transformation zone (LLETZ) for cervical intraepithelial neoplasia. METHODS: This was a retrospective cohort study of women who had a single cervical treatment between 2010 and 2011. We identified those women who had a singleton pregnancy subsequent to their cervical treatment until September 2017. Women with previous cervical treatment, previous miscarriage or preterm delivery were excluded...
February 5, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29404418/intravaginal-administration-of-interleukin-12-during-genital-gonococcal-infection-in-mice-induces-immunity-to-heterologous-strains-of-neisseria-gonorrhoeae
#15
Yingru Liu, Julianny Perez, Laura A Hammer, Heather C Gallagher, Magdia De Jesus, Nejat K Egilmez, Michael W Russell
It has previously been shown that genital tract infection with Neisseria gonorrhoeae in mice does not induce a state of protective immunity against reinfection but instead suppresses the development of adaptive immune responses against N. gonorrhoeae dependent on transforming growth factor beta (TGF-β) and interleukin 10 (IL-10). Intravaginal administration during gonococcal infection of IL-12 encapsulated in biodegradable microspheres (IL-12/ms) reverses the immunosuppression and promotes the production of gamma interferon (IFN-γ) and of specific antibodies in serum and genital secretions and accelerates clearance of the infection...
January 2018: MSphere
https://www.readbyqxmd.com/read/29400628/reproductive-factors-influencing-bone-mineral-density-in-postmenopausal-women
#16
Fatemeh Mohammadi, Jamileh Amirzadeh Iranagh, Seyedeh Ameneh Motalebi, Tengku Aizan Hamid
OBJECTIVE: This study examined the relationship between reproductive characteristics and bone mineral density in postmenopausal women who had been referred to the menopause clinics of the National Population and Family Development Board and of the Hospital Kuala Lumpur from July 2011 to January 2012. METHOD: The participants of this study were 201 postmenopausal Malaysian women aged 45-71 years. Some socio-demographic, life style and reproductive factors were recorded...
February 5, 2018: Women & Health
https://www.readbyqxmd.com/read/29400112/risk-of-neonatal-care-unit-admission-in-small-for-gestational-age-fetuses-at-term-a-prediction-model-and-internal-validation
#17
Erkan Kalafat, Jose Morales-Rosello, Basky Thilaganathan, Jasreen Dhother, Asma Khalil
OBJECTIVE: Small for gestational age (SGA) fetuses are at increased risk of admission to the neonatal unit, even at term. We aimed to develop and validate a predictive model for the risk of prolonged neonatal unit admission in suspected SGA fetuses at term. METHODS: A single-center cohort study of singleton pregnancies with SGA fetus, defined as estimated fetal weight (EFW) less than the 10th centile, at term. The variables included known risk factors for neonatal unit admissions: maternal characteristics, EFW, abdominal circumference (AC), fetal Dopplers, gestational age (GA) at delivery, and intrapartum risk factors (meconium, pyrexia)...
February 4, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29390911/social-obstetric-and-environmental-determinants-of-low-apgar-score-among-infants-born-in-four-selected-hospitals-in-ibadan-nigeria
#18
Folashade Olufunke Omokhodion, Olumuyiwa Adebola Roberts, Modupe Onayinka Onadeko, Jeremy Richard Beach, Nicola Cherry, Igor Burstyn
Little information exists about socio-economic, environmental or occupational determinants of low Apgar scores among Nigerian neonates. Mothers in lying-in wards of four hospitals in Ibadan were interviewed on socio-demographic characteristics, obstetric history and work activities during index pregnancy. Apgar scores and clinical data were extracted from case notes. Of the 1349 respondents, 20% had Apgar score <7 at one minute, 4% at five minutes. Lower education, cooking with kerosene, physical exertion at work, nulliparity, hypertension in pregnancy, prolonged rupture of membranes, breech presentation and caesarean section were predictors for low Apgar scores at one minute; nulliparity, male infant and breech presentation at five minutes...
February 1, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29385934/a-case-of-prolonged-hyperemesis-resulting-in-hepatorenal-failure-foetal-distress-and-neonatal-mortality
#19
Cemile Dayangan Sayan
Hyperemesis gravidarum is defined as a condition emerging during pregnancy, is prominent with severe nausea and vomiting, a water-electrolyte imbalance and liver-kidney function disorder and causes more than 5% loss of body weight. In cases of severe hyperemesis gravidarum, maternal morbidities such as water-electrolyte imbalance, hepatorenal failure, Wernicke's encephalopathy, splenic avulsion, oesophageal rupture, pneumothorax have been reported. We present a case of hyperemesis gravidarum, which continued until the third trimester and developed secondary hepatorenal failure, a water-electrolyte imbalance, intrauterine growth restriction, anhydramnios, foetal distress and neonatal mortality...
January 31, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29385123/rapid-autophagic-regression-of-the-milk-gland-during-involution-is-critical-for-maximizing-tsetse-viviparous-reproductive-output
#20
Joshua B Benoit, Veronika Michalkova, Elise M Didion, Yanyu Xiao, Aaron A Baumann, Geoffrey M Attardo, Serap Aksoy
Tsetse flies are important vectors of human and animal trypanosomiasis. Ability to reduce tsetse populations is an effective means of disease control. Lactation is an essential component of tsetse's viviparous reproductive physiology and requires a dramatic increase in the expression and synthesis of milk proteins by the milk gland organ in order to nurture larval growth. In between each gonotrophic cycle, tsetse ceases milk production and milk gland tubules undergo a nearly two-fold reduction in width (involution)...
January 31, 2018: PLoS Neglected Tropical Diseases
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