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Complex regional pain

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https://www.readbyqxmd.com/read/28717769/end-of-life-care-in-latin-america
#1
REVIEW
Enrique Soto-Perez-de-Celis, Yanin Chavarri-Guerra, Tania Pastrana, Rossana Ruiz-Mendoza, Alexandra Bukowski, Paul E Goss
Cancer has become a global pandemic with disproportionately higher mortality rates in low- and middle- income countries, where a large fraction of patients present in advanced stages and in need of end-of-life care. Globally, the number of adults needing end-of-life care is greater than 19 million, and up to 78% of these patients are living in low- and middle- income countries. In the Americas alone, more than one million people are in need of end-of-life care, placing an enormous burden on local health systems, which are often unprepared to meet the challenge presented by this complex patient population...
June 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/28716513/update-in-the-treatment-of-chronic-pain-within-pediatric-patients
#2
Jeffrey Rabin, Mackenzie Brown, Sean Alexander
Pediatric chronic pain is a challenging entity to evaluate and treat as it encompasses a wide variety of presentations often with overlapping psychosocial implications. Chronic pain may have significant effects upon a child's involvement in academic, athletic, and social participation. If unrecognized, it may have deleterious effects upon family interactions and stability. The treatment of pediatric chronic pain is focused on not only providing analgesia, but also on assisting the child and family with reintegrating into a more functional lifestyle...
July 14, 2017: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/28715350/a-prospective-multisite-international-validation-of-the-complex-regional-pain-syndrome-severity-score
#3
R Norman Harden, Christian Maihofner, Elias Abousaad, Jean-Jacques Vatine, Amy Kirsling, Roberto S G M Perez, Maxine Kuroda, Florian Brunner, Michael Stanton-Hicks, Johan Marinus, Jacobus J van Hilten, Sean Mackey, Frank Birklein, Tanja Schlereth, Angela Mailis-Gagnon, Joe Graciosa, Sara B Connoly, David Dayanim, Michael Massey, Hadas Frank, Anatoly Livshitz, Stephen Bruehl
Clinical diagnosis of complex regional pain syndrome (CRPS) is a dichotomous (yes/no) categorization, a format necessary for clinical decision making. Such dichotomous diagnostic categories do not convey an individual's subtle gradations in the severity of the condition over time and have poor statistical power when used as an outcome measure in research. This prospective, international, multicenter study slightly modified and further evaluated the validity of the CRPS Severity Score (CSS), a continuous index of CRPS severity...
August 2017: Pain
https://www.readbyqxmd.com/read/28713977/analysis-of-gene-expression-profile-microarray-data-in-complex-regional-pain-syndrome
#4
Wulin Tan, Yiyan Song, Chengqiang Mo, Shuangjian Jiang, Zhongxing Wang
The aim of the present study was to predict key genes and proteins associated with complex regional pain syndrome (CRPS) using bioinformatics analysis. The gene expression profiling microarray data, GSE47603, which included peripheral blood samples from 4 patients with CRPS and 5 healthy controls, was obtained from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) in CRPS patients compared with healthy controls were identified using the GEO2R online tool. Functional enrichment analysis was then performed using The Database for Annotation Visualization and Integrated Discovery online tool...
July 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28707576/new-strategies-for-the-prevention-and-treatment-of-systemic-and-local-bone-loss-from-pathophysiology-to-clinical-application
#5
A Fassio, Maurizio Rossini, Ombretta Viapiana, Luca Idolazzi, Camilla Benini, Elisabetta Vantaggiato, Davide Gatti
Bone loss is the result of a negative unbalance between bone formation ad bone resorption. In the last years, the studies on the Wnt canonical pathway have highlighted its crucial role in bone balance through its influence on the activity and maturation of the osteoblast line and in the Receptor Activator of Nuclear Factor κ B (RANK) - RANK ligand (RANKL)/Osteoprotegerin (OPG) system. These mechanisms are involved not only in the pathological processes inducing not only systemic bone loss (ie. Postmenopausal osteoporosis, glucocorticoid-induced osteoporosis, etc...
July 13, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28705011/the-experiences-and-beliefs-of-patients-with-complex-regional-pain-syndrome-an-exploratory-survey-study
#6
Adriaan Louw, Kory Zimney, Terry Cox, Christine O'Hotto, Craig A Wassinger
Objectives To determine the beliefs and describe the health care experiences of patients with complex regional pain syndrome. Methods A survey tool for patients with complex regional pain syndrome was designed for this study. The survey tool collected self-reported measures associated with pain, disability, health care experiences, education, beliefs, and treatments. Results Thirty-one patients attending physical therapy for complex regional pain syndrome (mean age 40.48; female n = 20) completed the survey...
January 1, 2017: Chronic Illness
https://www.readbyqxmd.com/read/28700507/pramipexole-induced-limb-dystonia-and-its-associated-complex-regional-pain-syndrome-in-idiopathic-parkinson-s-disease-a-case-report
#7
Donghwi Park
RATIONALE: This case may be due to basal ganglia dysfunction, which was probably caused by abnormal activation of dopamine 1-like receptor (D1R) boosted by pramipexole binding on dopamine 3-like receptor (D3R) in a situation where D3R was overexpressed by the chronic treatment of L-dopa. PATIENT CONCERNS: Striatal hand and foot deformities. DIAGNOSES: Striatal hand and foot deformities with CRPS. INTERVENTIONS: Steroid treatemnt and withdrawal of the pramipexole...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28693035/k2p2-1-trek-1-activator-complexes-reveal-a-cryptic-selectivity-filter-binding-site
#8
Marco Lolicato, Cristina Arrigoni, Takahiro Mori, Yoko Sekioka, Clifford Bryant, Kimberly A Clark, Daniel L Minor
Polymodal thermo- and mechanosensitive two-pore domain potassium (K2P) channels of the TREK subfamily generate 'leak' currents that regulate neuronal excitability, respond to lipids, temperature and mechanical stretch, and influence pain, temperature perception and anaesthetic responses. These dimeric voltage-gated ion channel (VGIC) superfamily members have a unique topology comprising two pore-forming regions per subunit. In contrast to other potassium channels, K2P channels use a selectivity filter 'C-type' gate as the principal gating site...
July 10, 2017: Nature
https://www.readbyqxmd.com/read/28692702/impaired-insula-functional-connectivity-associated-with-persistent-pain-perception-in-patients-with-complex-regional-pain-syndrome
#9
Jae-Hun Kim, Soo-Hee Choi, Joon Hwan Jang, Do-Hyeong Lee, Kyung-Jun Lee, Won Joon Lee, Jee Youn Moon, Yong Chul Kim, Do-Hyung Kang
Given that the insula plays a contributory role in the perception of chronic pain, we examined the resting-state functional connectivity between the insular cortex and other brain regions to investigate neural underpinnings of persisting perception of background pain in patients with complex regional pain syndrome (CRPS). A total of 25 patients with CRPS and 25 matched healthy controls underwent functional magnetic resonance imaging at rest. With the anterior and posterior insular cortices as seed regions, we compared the strength of the resting-state functional connectivity between the two groups...
2017: PloS One
https://www.readbyqxmd.com/read/28692507/eagle-syndrome-a-follow-up-examination-of-four-patients-after-surgical-treatment-via-cervical-approach
#10
Nils Heim, Anton Faron, Markus Martini, Rudolf H Reich
OBJECTIVE: Eagle syndrome is a rare pain syndrome caused by an elongated styloid apophysis or an ossified styloid ligament. It is characterized by a complex range of symptoms in head and neck region. The most effective treatment is surgical shortening of the styloid apophysis. The authors report of a follow-up examination of 4 patients after surgical treatment via cervical approach. METHODS: Retrospectively reviewed hospital records of 5 patients (4 females and 1 male), aged from 26 to 59 years old (mean age = 45...
July 7, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28691512/the-incidence-of-complex-regional-pain-syndrome-in-simultaneous-surgical-treatment-of-carpal-tunnel-syndrome-and-dupuytren-contracture
#11
Mitchell Buller, Steven Schulz, Morton Kasdan, Bradon J Wilhelmi
BACKGROUND: To determine the incidence of complex regional pain syndrome (CRPS) in the concurrent surgical treatment of Dupuytren contracture (DC) and carpal tunnel syndrome (CTS) through a thorough review of evidence available in the literature. METHODS: The indices of 260 hand surgery books and PubMed were searched for concomitant references to DC and CTS. Studies were eligible for inclusion if they evaluated the outcome of patients treated with simultaneous fasciectomy or fasciotomy for DC and carpal tunnel release using CRPS as a complication of treatment...
July 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28691184/risk-factors-for-post-treatment-complex-regional-pain-syndrome-crps-an-analysis-of-647-cases-of-crps-from-the-danish-patient-compensation-association
#12
Pelle B Petersen, Kim L Mikkelsen, Jes B Lauritzen, Michael R Krogsgaard
OBJECTIVES: Complex regional pain syndrome is a challenging condition including a broad spectrum of sensory, autonomic and motor features predominantly in extremities recovering from a trauma. Few large-scale studies have addressed occurrence of and factors associated with CRPS following orthopedic treatment. The present study aimed to identify factors associated with post-treatment development of CRPS. METHODS: Using the Danish Patient Compensation Association's (DPCA) database we identified 647 patients claiming post-treatment CRPS, between 1992 and 2015...
July 10, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28685627/hyperacusis-in-chronic-pain-neural-interactions-between-the-auditory-and-nociceptive-systems
#13
Aries P Suhnan, Philip M Finch, Peter D Drummond
OBJECTIVE: Sensory disturbances are common in chronic pain patients. Hyperacusis can be an especially debilitating experience. Here, we review published work on how the auditory and nociceptive systems might interact in chronic pain syndromes to produce pain-hyperacusis. DESIGN: Literature review. STUDY SAMPLE: The PubMed and Scopus databases were searched for relevant articles published between 2000 and 2017 using the primary search terms "hyperacusis"/"hyperacousis" and "pain"...
July 7, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28673417/neurologic-injuries-in-noncontact-sports
#14
REVIEW
Robert J Marquardt, Andrew Blake Buletko, Andrew Neil Russman
Noncontact sports are associated with a variety of neurologic injuries. Concussion, vascular injury (arterial dissection), and spinal cord trauma may be less common in noncontact sports, but require special attention from the sports neurologist. Complex regional pain disorders, muscle injury from repetitive use, dystonia, heat exposure, and vascular disorders (patent foramen ovale), occur with similar frequency in noncontact and contact sports. Management of athletes with these conditions requires an understanding of the neurologic consequences of these disorders, the risk of injury with return to play, and consideration for the benefits of exercise in health restoration and disease prevention...
August 2017: Neurologic Clinics
https://www.readbyqxmd.com/read/28670058/management-of-complex-regional-pain-syndrome
#15
Jason Chung-Chieh Lo, Joel Cavazos, Christopher Burnett
Complex regional pain syndrome (CRPS) is a relatively rare, chronic, and debilitating condition that significantly impacts the patient's quality of life. There is an overall paucity of literature addressing the management of CRPS in immunocompromised patients. We define features of CRPS, outline its treatment options, and describe a course of CRPS management for a 35-year-old patient who had heart transplantation requiring immunosuppressive medications.
July 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28656207/expression-of-granulocyte-colony-stimulating-factor-3-receptor-in-the-spinal-dorsal-horn-following-spinal-nerve-ligation-induced-neuropathic-pain
#16
Enji Zhang, Sunyeul Lee, Min-Hee Yi, Yongshan Nan, Yinshi Xu, Nara Shin, Youngkwon Ko, Young Ho Lee, Wonhyung Lee, Dong Woon Kim
In previous studies that have profiled gene expression in patients with complex regional pain syndrome (CRPS), the expression of granulocyte colony-stimulating factor 3 receptor (G‑CSFR) was elevated, as were a number of pain‑associated genes. The present study determined the expression of G‑CSFR and the mechanisms by which it may affect hypersensitivity, focusing on the signal transducer and activator of transcription 3 (STAT3)/transient receptor potential cation channel subfamily V 1 (TRPV1) signaling pathway in particular, which is an important mediator of pain...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28654557/the-effectiveness-of-transcranial-direct-current-stimulation-as-an-add-on-modality-to-graded-motor-imagery-for-treatment-of-complex-regional-pain-syndrome-a-randomized-proof-of-concept-study
#17
Émilie Lagueux, Michaël Bernier, Patricia Bourgault, Kevin Whittingstall, Catherine Mercier, Guillaume Léonard, Sarah Laroche, Yannick Tousignant-Laflamme
BACKGROUND: The efficacy of graded motor imagery (GMI) for the management of complex regional pain syndrome (CRPS) is supported by evidence, but its treatment effect remains generally modest. Transcranial direct current stimulation (tDCS) has been advocated as an adjunct intervention to enhance the effect of motor imagery approaches in pain populations. OBJECTIVE: The purpose of this study was to investigate the effectiveness of GMI+active tDCS compared to the GMI+sham tDCS in the treatment of CRPS type I...
June 16, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28646349/modeling-pain-using-fmri-from-regions-to-biomarkers
#18
REVIEW
Marianne C Reddan, Tor D Wager
Pain is a subjective and complex phenomenon. Its complexity is related to its heterogeneity: multiple component processes, including sensation, affect, and cognition, contribute to pain experience and reporting. These components are likely to be encoded in distributed brain networks that interact to create pain experience and pain-related decision-making. Therefore, to understand pain, we must identify these networks and build models of these interactions that yield testable predictions about pain-related outcomes...
June 23, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28638948/does-socioeconomic-status-influence-the-epidemiology-and-outcome-of-distal-radial-fractures-in-adults
#19
N D Clement, A D Duckworth, N R Wickramasinghe, C M Court-Brown, M M McQueen
PURPOSE: The aim of this study in adult patients with a distal radial fracture was to determine whether socioeconomic status influenced the epidemiology, mechanism of injury, fracture severity, or the outcome according to function, radiographic assessment, and rate of associated complications. METHODS: We identified 3983 distal radial fractures over a 7-year period. Socioeconomic status was assigned using the Carstairs score, and the population was divided into quintiles depending on deprivation...
June 21, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28638296/ultrasound-guided-percutaneous-cervical-and-upper-thoracic-sympathetic-chain-neuromodulation-for-upper-extremity-complex-regional-pain-syndrome
#20
Samer Narouze, Dmitri Souzdalnitski
BACKGROUND: Complex regional pain syndrome (CRPS) comprises a group of conditions characterized by severe, debilitating pain that is disproportionate to any inciting event and is not distributed in a specific nerve distribution or dermatome. CASE REPORT: A 42-year-old female with a 2-year history of right upper extremity CRPS type I refractory to conventional management underwent an ultrasound-guided and fluoroscopy confirmed percutaneous peripheral nerve stimulation trial with a lead extending from the C6 to the T3 level to cover the cervical and upper thoracic sympathetic chain...
2017: Ochsner Journal
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