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Complex regional pain

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https://www.readbyqxmd.com/read/28635316/complications-following-collagenase-treatment-for-dupuytren-contracture
#1
Jennifer Wozniczka, Clifford Canepa, Adam Mirarchi, Joel S Solomon
BACKGROUND: Collagenase Clostridium histolyticum (CCH) injection and manipulation is a relatively new method for treating Dupuytren contracture that is growing in popularity. Although side effects such as swelling and ecchymosis are common, they are typically mild and self-limited. Major complications are rare but have included flexor tendon rupture and complex regional pain syndrome. METHODS: This study describes a case report of 2 patients seen at our institution...
June 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28634419/elevated-plasma-levels-of-sil-2r-in-complex-regional-pain-syndrome-a-pathogenic-role-for-t-lymphocytes
#2
Krishna D Bharwani, Maaike Dirckx, Dirk L Stronks, Willem A Dik, Marco W J Schreurs, Frank J P M Huygen
The immune system has long been thought to be involved in the pathophysiology of complex regional pain syndrome (CRPS). However, not much is known about the role of the immune system and specifically T-cells in the onset and maintenance of this disease. In this study, we aimed to evaluate T-cell activity in CRPS by comparing blood soluble interleukin-2 receptor (sIL-2R) levels between CRPS patients and healthy controls. CRPS patients had statistically significant elevated levels of sIL-2R as compared to healthy controls (median sIL-2R levels: 4151 pg/ml (Q3 - Q1 = 5731 pg/ml - 3546 pg/ml) versus 1907 pg/ml (Q3 - Q1: 2206 pg/ml - 1374 pg/ml), p < 0...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28625431/fishing-for-answers-in-an-ocean-of-data-the-potential-for-big-data-analytics-to-enhance-our-knowledge-of-the-complex-regional-pain-syndromes
#3
EDITORIAL
Frederick Burgess, Keith Fragoza
No abstract text is available yet for this article.
August 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28621025/dorsal-root-ganglion-stimulation-as-a-salvage-treatment-for-complex-regional-pain-syndrome-refractory-to-dorsal-column-spinal-cord-stimulation-a-case-series
#4
Ajax Yang, Corey W Hunter
OBJECTIVE: The efficacy of traditional spinal cord stimulation (t-SCS) tends to decay over time in patients with complex regional pain syndrome (CRPS). While it has been shown that dorsal root ganglion (DRG) stimulation is extremely effective in t-SCS-naïve patients with CRPS, its efficacy in patients who had previously failed t-SCS is unknown. Given that DRG-SCS and t-SCS target different spinal pathways, a failure with t-SCS should not automatically preclude a patient from attempting DRG-SCS...
June 16, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28616655/-cognitive-perceptive-approaches-in-the-treatment-of-chronic-pain
#5
REVIEW
C Storz, H Schulte-Göcking, M Azqueta, C Wania, M Neugebauer, A Reiners, S Azad, E Kraft
In the treatment of difficult chronic pain conditions, cognitive-perceptive approaches offer an alternative to conventional therapies. Especially phantom limb pain and complex regional pain syndrome (CRPS) are frequently treated with these promising modalities. This article provides an overview of the most important cognitive-perceptive therapies and the research results concerning their clinical efficacy. In addition, we discuss their neurobiological foundation and clinical perspectives.
June 14, 2017: Der Schmerz
https://www.readbyqxmd.com/read/28611234/complex-regional-pain-syndrome-diagnosed-with-three-phase-bone-scan
#6
Harleen Kaur, Mitchel A Muhleman, Helena R Balon
In this report, we present a case of complex regional pain syndrome in a 55-year-old female in whom the diagnosis was made based on the bone scan findings. We also discuss the typical and atypical scintigraphic presentations of this entity, including pathophysiology and management.
June 13, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28610824/safety-and-perception-what-are-the-greatest-enemies-of-hpv-vaccination-programmes
#7
Paolo Bonanni, Beatrice Zanella, Francesca Santomauro, Chiara Lorini, Angela Bechini, Sara Boccalini
Vaccines stimulate a person's immune system to produce an adequate reaction against a specific infectious agent; i.e. the person is protected from that disease without having to get it first. As vaccines are administrated to healthy subjects, they are held to the highest standards of safety. Regarding human papillomavirus (HPV) vaccines, at present three prophylactic vaccines are licensed (bivalent HPV 16/18, quadrivalent HPV 6/11/16/18 and the nonovalent HPV 6/11/16/18/31/33/45/52/58 vaccine). Pre- and post-licensure studies (i...
June 10, 2017: Vaccine
https://www.readbyqxmd.com/read/28609560/resolving-the-contributions-of-anaesthesia-surgery-and-nerve-injury-on-brain-derived-neurotrophic-factor-expression-in-the-medial-prefrontal-cortex-of-male-rats-in-the-cci-model-of-neuropathic-pain
#8
James W M Kang, Kevin A Keay, David Mor
The medial prefrontal cortex (mPFC) is critical for selecting and shaping complex behavioral responses. In rodent models of neuropathic pain there is evidence for both structural and functional changes in the mPFC. Brain derived neurotrophic factor (BDNF) plays a critical role in the normal functioning of the mPFC. It has been suggested that the disruption of complex behaviors and mood seen in some neuropathic pain patients is mediated in part by alterations of BDNF in this cortical region. In Sprague-Dawley rats, mPFC levels of BDNF and TrkB mRNA and protein, were quantified and compared to controls (n = 24) 6 days after either: (a) halothane (1...
June 13, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28609318/biochemical-and-pharmacological-characterization-of-a-mice-model-of-complex-regional-pain-syndrome
#9
Vaskar Das, Jeffrey S Kroin, Mario Moric, Asokumar Buvanendran
BACKGROUND AND OBJECTIVES: Complex regional pain syndrome is a challenging disease to treat. Recently, a mouse fracture model of complex regional pain syndrome has been developed that has many signs of the clinical syndrome. However, many aspects of the sensory neuron biochemistry and behavioral and pharmacological characterization of this model remain to be clarified. METHODS: Mice were randomly assigned to fracture/cast or control (naive) groups. Fracture/cast mice underwent a closed distal tibia facture, with hindlimb wrapped in casting tape for 3 weeks...
July 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28605398/risk-factors-for-shoulder-pain-in-a-cohort-of-french-workers-a-structural-equation-model
#10
Julie Bodin, Ronan Garlantézec, Nathalie Costet, Alexis Descatha, Jean-François Viel, Yves Roquelaure
Shoulder pain is common in the working population and causes loss of productivity, high economic costs and long periods of absence. Simultaneous evaluation of the complex relationships between work organization, psychosocial and physical risk factors, stress and shoulder pain is rare. The aim of this study was to explore the direct and indirect relationships between workplace risk factors, perceived stress and occurrence of shoulder pain in workers of the Cosali study. A total of 3,710 workers of a French region were randomly included between 2002 and 2005...
June 9, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28594885/effect-of-a-new-formulation-of-micronized-and-ultramicronized-n-palmitoylethanolamine-in-a-tibia-fracture-mouse-model-of-complex-regional-pain-syndrome
#11
Roberta Fusco, Enrico Gugliandolo, Michela Campolo, Maurizio Evangelista, Rosanna Di Paola, Salvatore Cuzzocrea
Complex regional pain syndrome type 1 (CRPS-I) is a disabling and frequently chronic condition. It involves the extremities and is a frequent consequence of distal tibia and radius fractures. The inflamed appearance of the affected CRPS-I limb suggests that local production of inflammatory mediators may be implicated in the ensuing etiology. A rodent tibia fracture model, characterized by inflammation, chronic unilateral hindlimb warmth, edema, protein extravasation, allodynia and hyperalgesia resembles the clinical features of patients with acute CRPS-I...
2017: PloS One
https://www.readbyqxmd.com/read/28593417/laparoscopic-approach-for-the-treatment-of-chronic-groin-pain-after-inguinal-hernia-repair-laparoscopic-approach-for-inguinodynia
#12
Bruce Ramshaw, Vincent Vetrano, Mayuri Jagadish, Brandie Forman, Eric Heidel, Matthew Mancini
BACKGROUND: Traditional methods of clinical research may not be adequate to improve the value of care for patients with complex medical problems such as chronic pain after inguinal hernia repair. This problem is very complex with many potential factors contributing to the development of this complication. METHODS: We have implemented a clinical quality improvement (CQI) effort in an attempt to better measure and improve outcomes for patients suffering with chronic groin pain (inguinodynia) after inguinal hernia repair...
June 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28592893/regional-brain-functions-in-the-resting-state-indicative-of-potential-differences-between-depression-and-chronic-pain
#13
Atsuo Yoshino, Yasumasa Okamoto, Mitsuru Doi, Naofumi Otsuru, Go Okada, Masahiro Takamura, Naho Ichikawa, Satoshi Yokoyama, Hidehisa Yamashita, Shigeto Yamawaki
Complex relationships between depression and chronic pain have been reported in previous studies. However, only a few neuroimaging studies have investigated similarities and differences in neural systems underlying them. We examined the brain functions in the resting state of 43 patients with depression, 41 patients with chronic pain (somatoform pain disorder) and 41 healthy controls, by using regional homogeneity (ReHo) and functional connectivity analysis. Depressive symptoms were assessed by using the Beck Depression Inventory-Second Edition (BDI-II)...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28590302/a-subregion-of-the-parabrachial-nucleus-partially-mediates-respiratory-rate-depression-from-intravenous-remifentanil-in-young-and-adult-rabbits
#14
Justin R Miller, Edward J Zuperku, Eckehard A E Stuth, Anjishnu Banerjee, Francis A Hopp, Astrid G Stucke
BACKGROUND: The efficacy of opioid administration to reduce postoperative pain is limited by respiratory depression. We investigated whether clinically relevant opioid concentrations altered the respiratory pattern in the parabrachial nucleus, a pontine region contributing to respiratory pattern generation, and compared these effects with a medullary respiratory site, the pre-Bötzinger complex. METHODS: Studies were performed in 40 young and 55 adult artificially ventilated, decerebrate rabbits...
June 6, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28573699/painful-swelling-after-a-noxious-event-and-the-development-of-complex-regional-pain-syndrome-1-a-one-year-prospective-study
#15
F Brunner, L M Bachmann, R S G M Perez, J Marinus, M M Wertli
BACKGROUND: The timing of diagnosis of complex regional pain syndrome (CRPS) 1 remains a challenge due to the large heterogeneity of clinical presentations. We describe the distribution and differences in outcomes and clinical manifestations between time points and patient groups with and without CRPS 1 following an initiating event. METHODS: Prospective cohort study with a consecutive registration of patients presenting with painful swelling of the affected extremity after an initiating event and follow-up visits after 3, 6 and 12 months...
June 2, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28564673/postoperative-multimodal-analgesia-pain-management-with-nonopioid-analgesics-and-techniques-a-review
#16
Elizabeth C Wick, Michael C Grant, Christopher L Wu
Importance: Amid the current opioid epidemic in the United States, the enhanced recovery after surgery pathway (ERAS) has emerged as one of the best strategies to improve the value and quality of surgical care and has been increasingly adopted for a broad range of complex surgical procedures. The goal of this article was to outline important components of opioid-sparing analgesic regimens. Observations: Regional analgesia, acetaminophen, nonsteroidal anti-inflammatory agents, gabapentinoids, tramadol, lidocaine, and/or the N-methyl-d-aspartate class of glutamate receptor antagonists have been shown to be effective adjuncts to narcotic analgesia...
May 31, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28554710/the-pecs-ii-block-as-a-major-analgesic-component-for-clavicle-operations-a-description-of-7-case-reports
#17
J B Schuitemaker R, X Sala-Blanch, C L Rodriguez-Pérez, J T Mayoral R, L A López-Pantaleon, A P Sánchez-Cohen
Clavicle fractures correspond to 35% of traumatic fractures of the shoulder girdle. Regional anaesthesia has shown better analgesic results than systemic treatment for perioperative management. Innervation of the clavicle is complex, at present its knowledge raises controversy. The lateral pectoral nerve through the innervating musculature predominantly participates in the lateral and anterior part of the clavicle. The following report of 7 cases describes the effective postoperative analgesia of modified PEC II block in patients with middle third clavicle fracture or acromioclavicular dislocation who underwent a modified PEC II block for postoperative pain management, in the context of a multimodal analgesia...
May 26, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28552760/denervation-of-the-wrist%C3%A2-with-two-surgical-incisions-is-it-effective-a-review-of-33-patients-with-an-average-of-41months-follow-up
#18
S Delclaux, F Elia, C Bouvet, C Aprédoaei, M Rongières, P Mansat
The goal of wrist denervation is to decrease pain at the wrist, whether caused by an intra- or extra-articular problem or even when the reason for the pain is unknown. It is an alternative to partial or total arthrodesis and proximal row carpectomy. Our hypothesis was that wrist denervation with a two-incision technique was a reliable and efficient way to treat painful degenerative wrists. Thirty-three patients, 48years old on average, were included in this study. Indications were scapholunate advanced collapse (SLAC) in 18 cases, scaphoid nonunion advanced collapse (SNAC) in 10, distal radius fracture sequelae with advanced radiocarpal osteoarthritis in 4, and post-traumatic ulnocarpal impingement in 1 case...
May 25, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28540568/-tibial-pilon-fractures-advoidance-and-therapy-of-complications
#19
REVIEW
Ralph Gaulke, Christian Krettek
Because of the complex fracture morphology and vulnerable soft tissue coverage, fractures of the tibial pilon are difficult to treat. Complications are more common than in bi- or trimalleolar fractures. The surgeon has to know about the special risks of these injuries to avoid complications. Early complications are soft tissue necrosis, persisting fragment dislocations after surgery, loss of reposition and deep wound infection. The surgeon has to be aware of early signs of compartment-syndrome and chronic regional pain syndrome (CRPS)...
May 24, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28534443/cd59-polymorphisms-are-associated-with-gene-expression-and-different-sexual-susceptibility-to-pemphigus-foliaceus
#20
Amanda Salviano-Silva, Maria Luiza Petzl-Erler, Angelica Beate Winter Boldt
Pemphigus foliaceus (PF) is an autoimmune disease, endemic in Brazilian rural areas, characterized by acantholysis and accompanied by complement activation, with generalized or localized distribution of painful epidermal blisters. CD59 is an essential complement regulator, inhibiting formation of the membrane attack complex, and mediating signal transduction and activation of T lymphocytes. CD59 has different transcripts by alternative splicing, of which only two are widely expressed, suggesting the presence of regulatory sites in their noncoding regions...
May 23, 2017: Autoimmunity
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