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Complex regional pain

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https://www.readbyqxmd.com/read/28540568/-tibial-pilon-fractures-advoidance-and-therapy-of-complications
#1
REVIEW
Ralph Gaulke, Christian Krettek
Because of the complex fracture morphology and vulnerable soft tissue coverage, fractures of the tibial pilon are difficult to treat. Complications are more common than in bi- or trimalleolar fractures. The surgeon has to know about the special risks of these injuries to avoid complications. Early complications are soft tissue necrosis, persisting fragment dislocations after surgery, loss of reposition and deep wound infection. The surgeon has to be aware of early signs of compartment-syndrome and chronic regional pain syndrome (CRPS)...
May 24, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28534443/cd59-polymorphisms-are-associated-with-gene-expression-and-different-sexual-susceptibility-to-pemphigus-foliaceus
#2
Amanda Salviano-Silva, Maria Luiza Petzl-Erler, Angelica Beate Winter Boldt
Pemphigus foliaceus (PF) is an autoimmune disease, endemic in Brazilian rural areas, characterized by acantholysis and accompanied by complement activation, with generalized or localized distribution of painful epidermal blisters. CD59 is an essential complement regulator, inhibiting formation of the membrane attack complex, and mediating signal transduction and activation of T lymphocytes. CD59 has different transcripts by alternative splicing, of which only two are widely expressed, suggesting the presence of regulatory sites in their noncoding regions...
May 23, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28525735/structure-based-rational-design-of-self-inhibitory-peptides-to-disrupt-the-intermolecular-interaction-between-the-troponin-subunits-c-and-i-in-neuropathic-pain
#3
Junmin Yu, Shilei Wang, Junjie Yu, Chuansheng Liu, Fenghe Xu, Shijie Wang, Yusheng Yi, Yanwei Yin
The troponin (Tn) is a ternary complex consisting of three subunits TnC, TnI and TnT; molecular disruption of the Tn complex has been recognized as an attractive strategy against neuropathic pain. Here, a self-inhibitory peptide is stripped from the switch region of TnI interaction interface with TnC, which is considered as a lead molecular entity and then used to generate potential peptide disruptors of TnC-TnI interaction based on a rational molecular design protocol. The region is a helical peptide segment capped by N- and C-terminal disorders...
May 3, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28523214/complex-regional-pain-syndrome-the-matter-of-white-matter
#4
Jaakko Hotta, Guangyu Zhou, Hanna Harno, Nina Forss, Riitta Hari
INTRODUCTION: Many central pathophysiological aspects of complex regional pain syndrome (CRPS) are still unknown. Although brain-imaging studies are increasingly supporting the contribution of the central nervous system to the generation and maintenance of the CRPS pain, the brain's white-matter alterations are seldom investigated. METHODS: In this study, we used diffusion tensor imaging to explore white-matter changes in twelve CRPS-type-1 female patients suffering from chronic right upper-limb pain compared with twelve healthy control subjects...
May 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28522185/orofacial-complex-regional-pain-syndrome-pathophysiologic-mechanisms-and-functional-mri
#5
Yeon-Hee Lee, Kyung Mi Lee, Hyug-Gi Kim, Soo-Kyung Kang, Q-Schick Auh, Jyung-Pyo Hong, Yang-Hyun Chun
Complex regional pain syndrome (CRPS) is one of the most challenging chronic pain conditions and is characterized by burning pain, allodynia, hyperalgesia, autonomic changes, trophic changes, edema, and functional loss involving mainly the extremities. Until recently, very few reports have been published concerning CRPS involving the orofacial area. We report on a 50-year-old female patient who presented with unbearable pain in all of her teeth and hypersensitivity of the facial skin. She also reported intractable pain in both extremities accompanied by temperature changes and orofacial pain that increased when the other pains were aggravated...
March 14, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28501479/risk-factors-for-complex-regional-pain-syndrome-in-patients-with-surgically-treated-traumatic-injuries-attending-hand-therapy
#6
Serpil Savaş, Esra Erkol İnal, Dudu Dilek Yavuz, Fuat Uslusoy, Selman Hakkı Altuntaş, Mustafa Asım Aydın
STUDY DESIGN: Prospective cohort study. INTRODUCTION: Identification of risk factors for CRPS development in patients with surgically treated traumatic injuries attending hand therapy allows to watch at-risk patients more closely for early diagnosis and to take precautionary measures as required. PURPOSE OF THE STUDY: The aim of this study was to evaluate the risk factors for the development of complex regional pain syndrome (CRPS) after surgical treatment of traumatic hand injuries...
May 10, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28494904/complex-regional-pain-syndrome-type-1-predictors-epidemiological-perspective-from-a-national-database-analysis
#7
Ahmad Elsharydah, Nathaniel H Loo, Abu Minhajuddin, Enas S Kandil
OBJECTIVE: Complex regional pain syndrome type 1 is a disabling pain disorder with unclear etiology. It is usually triggered by an injury to a limb with or without specific nerve injury. The objective of this study is to explore the risk factors and predictors for this disease utilizing a large national database. DESIGN: Retrospective analysis of the Nationwide Inpatient Sample database from 2007 to 2011 in the United States. SETTING AND PATIENTS: Adult inpatients diagnosed with complex regional pain syndrome type 1...
June 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28492436/continuous-regional-anesthesia-and-inpatient-rehabilitation-for-pediatric-complex-regional-pain-syndrome
#8
Carolina Donado, Kimberly Lobo, María Fe Velarde-Álvarez, Joseph Kim, Anne Kenney, Deirdre Logan, Charles B Berde
BACKGROUND: Evidence supports treatment of pediatric complex regional pain syndromes (CRPS) with physical and occupational therapy and cognitive-behavioral therapy. Some patients have persistent pain and/or limb dysfunction despite these treatments. We performed a retrospective study of pediatric patients with CRPS treated by continuous epidural or peripheral perineural local anesthetic infusions along with inpatient rehabilitation at Boston Children's Hospital. METHODS: After approval from the institutional review board, electronic medical records were reviewed for patients treated between September 2003 and September 2014...
May 10, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28491301/short-and-long-term-results-of-an-inpatient-programme-to-manage-complex-regional-pain-syndrome-in-children-and-adolescents
#9
Giovanni Cucchiaro, Kevin Craig, Kerri Marks, Kristin Cooley, Thalitha Kay Black Cox, Jennifer Schwartz
The aim of this retrospective study was to determine whether an inpatient approach and the use of regional anaesthesia techniques can accelerate the recovery to normal functions in children with Complex Regional Pain Syndrome (CRPS). This study looked at the data of patients admitted to the rehabilitation unit with a diagnosis of CRPS from January 2010 to April 2015. Variables such as hospital stay, medications administered, regional anaesthesia procedures, changes in functional status prior to treatment and at the time of discharge, psychological evaluation and diagnosis were evaluated...
May 2017: British Journal of Pain
https://www.readbyqxmd.com/read/28483595/mefv-mutations-and-their-relation-to-major-clinical-symptoms-of-familial-mediterranean-fever
#10
Nilgun Cekin, Murat Eser Akyurek, Ergun Pinarbasi, Filiz Ozen
Familial Mediterranean fever is a common hereditary disease in Turkey. To date, different mutational spectrum of MEFV gene was observed in studies carried out in different regions of Turkey but in most of these studies association of clinical symptoms of FMF to mutant genotypes have not been investigated in details. Here we report the MEFV gene variations in exons 2, 3, 5 and 10 and their relations to major clinical symptoms of FMF in 514 unrelated (245 males and 269 females) Turkish patients. MEFV mutations were found in 45% (n=230) of patients and 55% (n=284) of patients did not have any mutations...
May 5, 2017: Gene
https://www.readbyqxmd.com/read/28471312/the-scandinavian-baltic-pancreatic-club-sbpc-database-design-rationale-and-characterisation-of-the-study-cohort
#11
Søren S Olesen, Jakob L Poulsen, Asbjørn M Drewes, Jens B Frøkjær, Johanna Laukkarinen, Mikael Parhiala, Iben Rix, Srdan Novovic, Björn Lindkvist, Louise Bexander, Georg Dimcevski, Trond Engjom, Friedemann Erchinger, Ingfrid S Haldorsen, Aldis Pukitis, Imanta Ozola-Zālīte, Stephan Haas, Miroslav Vujasinovic, J Matthias Löhr, Antanas Gulbinas, Nanna M Jensen, Maiken T Jørgensen, Camilla Nøjgaard
OBJECTIVES: Chronic pancreatitis (CP) is a multifaceted disease associated with several risk factors and a complex clinical presentation. We established the Scandinavian Baltic Pancreatic Club (SBPC) Database to characterise and study the natural history of CP in a Northern European cohort. Here, we describe the design of the database and characteristics of the study cohort. METHODS: Nine centres from six different countries in the Scandinavian-Baltic region joined the database...
May 4, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28467566/-spinal-cord-stimulation-in-62-patients-retrospective-evaluation
#12
İrem Özdemir, Mert Akbaş, Arif Yeğin, Gözde Dağıstan, Deniz Özel Erkan
OBJECTIVES: Spinal cord stimulation (SCS) is used for various indications such as Failed Back Surgey Syndrome, peripheral causalgia, neuropathic pain, complex regional pain syndrome, reflex sympathetic dystrophy, peripheral vascular disease, ischemic heart disease and cancer pain. METHODS: This is a retrospective study. 62 patients applied SCS were included in retrospective study from february 2011-january 2015 in Akdeniz University medicine faculty algology department...
January 2017: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/28466257/cortical-representation-of-pain-and-touch-evidence-from-combined-functional-neuroimaging-and-electrophysiology-in-non-human-primates
#13
REVIEW
Li Min Chen
Human functional MRI studies in acute and various chronic pain conditions have revolutionized how we view pain, and have led to a new theory that complex multi-dimensional pain experience (sensory-discriminative, affective/motivational, and cognitive) is represented by concurrent activity in widely-distributed brain regions (termed a network or pain matrix). Despite these breakthrough discoveries, the specific functions proposed for these regions remain elusive, because detailed electrophysiological characterizations of these regions in the primate brain are lacking...
May 2, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28465194/physical-therapy-under-hypnosis-for-the-treatment-of-patients-with-type-1-complex-regional-pain-syndrome-of-the-hand-and-wrist-retrospective-study-of-20-cases
#14
J Lebon, M Rongières, C Apredoaei, S Delclaux, P Mansat
Type 1 complex regional painful syndrome (CRPS-1) has a complex physiopathology. The aim of this study was to evaluate the effectiveness of physical therapy under hypnotherapy to treat this condition. Twenty patients with CRPS-1 at the wrist and hand were evaluated retrospectively: 13 women and 7 men with an average age of 56 years (34-75). Thirteen patients were in the inflammatory phase and 7 in the dystrophic phase. The main endpoints were pain (VAS, analgesic use), stiffness (wrist and finger range of motion), and strength (pinch and grasp)...
March 1, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28465193/clinical-outcomes-of-proximal-row-carpectomy-by-preoperative-midcarpal-joint-morphological-classification-viegas-type-i-versus-type-ii
#15
A Toffoli, H Lenoir, C Lazerges, B Coulet, M Chammas
The midcarpal joint can be classified into two anatomical types - Viegas type I and Viegas type II - based on the absence or presence of a medial facet for the hamate on the lunate (lunohamate facet). Type I is associated with a round capitate shape, which theoretically allows better congruence with the lunate fossa of the distal radius following proximal row carpectomy (PRC). This morphological feature has never been considered as a predictive factor of clinical outcome for this surgical procedure. This study aimed to compare the clinical and radiological outcomes of the two Viegas types following PRC...
February 28, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28464900/application-of-real-time-global-media-monitoring-and-derived-questions-for-enhancing-communication-by-regulatory-bodies-the-case-of-human-papillomavirus-vaccines
#16
Priya Bahri, Julianna Fogd, Daniel Morales, Xavier Kurz
BACKGROUND: The benefit-risk balance of vaccines is regularly debated by the public, but the utility of media monitoring for regulatory bodies is unclear. A media monitoring study was conducted at the European Medicines Agency (EMA) concerning human papillomavirus (HPV) vaccines during a European Union (EU) referral procedure assessing the potential causality of complex regional pain syndrome (CRPS) and postural orthostatic tachycardia syndrome (POTS) reported to the authorities as suspected adverse reactions...
May 2, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28460699/case-study-of-high-dose-ketamine-for-treatment-of-complex-regional-pain-syndrome-in-the-pediatric-intensive-care-unit
#17
REVIEW
Tracy Ann Pasek, Kelli Crowley, Catherine Campese, Rachel Lauer, Charles Yang
Complex regional pain syndrome (CRPS) is a life-altering and debilitating chronic pain condition. The authors are presenting a case study of a female who received high-dose ketamine for the management of her CRPS. The innovative treatment lies not only within the pharmacologic management of her pain, but also in the fact that she was the first patient to be admitted to our pediatric intensive care unit solely for pain control. The primary component of the pharmacotherapy treatment strategy plan was escalating-dose ketamine infusion via patient-controlled-analgesia approved by the pharmacy and therapeutics committee guided therapy for this patient...
June 2017: Critical Care Nursing Clinics of North America
https://www.readbyqxmd.com/read/28460075/perineural-injection-therapy-in-the-management-of-complex-regional-pain-syndrome-a-sweet-solution-to-pain
#18
Ju Ann Thor, Nor Hanim Mohamed Hanapi, Hazwani Halil, Anwar Suhaimi
No abstract text is available yet for this article.
April 26, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28454663/a-thematic-analysis-of-messages-posted-by-moderators-within-health-related-asynchronous-online-support-forums
#19
Richard M Smedley, Neil S Coulson
OBJECTIVE: To identify and describe the activities performed by online support community moderators. METHODS: A total of 790 messages were downloaded for analysis. Messages were written by 59 moderators from 6 forums that represent a diverse range of conditions (arthritis, complex regional pain syndrome, Crohn's disease, depression, diabetes and Huntington's disease). RESULTS: Thematic analysis revealed four themes: supportive tasks supportive tasks involve providing help to members, moderators sharing experiences shows how they use forums to fulfil their own personal support needs, making announcements about new discoveries and upcoming events, and administrative tasks such as enforcing rules and deleting spam...
April 13, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28443062/somatosensory-misrepresentation-associated-with-chronic-pain-spatiotemporal-correlates-of-sensory-perception-in-a-patient-following-a-complex-regional-pain-syndrome-spread
#20
Lars Büntjen, Jens-Max Hopf, Christian Merkel, Jürgen Voges, Stefan Knape, Hans-Jochen Heinze, Mircea Ariel Schoenfeld
Chronic pain is suggested to be linked to reorganization processes in the sensorimotor cortex. In the current study, the somatosensory representation of the extremities was investigated in a patient with a complex regional pain syndrome (CRPS) that initially occurred in the right hand and arm and spread later into the left hand and right leg. After the spread, magnetoencephalographic recordings in conjunction with somatosensory stimulation revealed that the clinical symptoms were associated with major changes in the primary somatosensory representation...
2017: Frontiers in Neurology
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