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PTSD, Acute Stress Disorder

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https://www.readbyqxmd.com/read/28087128/intranasal-oxytocin-to-prevent-posttraumatic-stress-disorder-symptoms-a-randomized-controlled-trial-in-emergency-department-patients
#1
Mirjam van Zuiden, Jessie L Frijling, Laura Nawijn, Saskia B J Koch, J Carel Goslings, Jan S Luitse, Tessa H Biesheuvel, Adriaan Honig, Dick J Veltman, Miranda Olff
BACKGROUND: There are currently few preventive interventions available for posttraumatic stress disorder (PTSD). Intranasal oxytocin administration early after trauma may prevent PTSD, because oxytocin administration was previously found to beneficially impact PTSD vulnerability factors, including neural fear responsiveness, peripheral stress reactivity, and socioemotional functioning. Therefore, we investigated the effects of intranasal oxytocin administration early after trauma on subsequent clinician-rated PTSD symptoms...
December 8, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/28051993/serotonergic-synergy-in-the-pharmacotherapy-of-acute-posttraumatic-stress-disorder-exacerbation-a-case-report
#2
J Gibson Pennington, Jeffrey Guina
OBJECTIVE: Posttraumatic stress disorder (PTSD) is often associated with acute panic, dissociation, suicidality, and aggression. However, pharmacologic interventions for such acute exacerbations are understudied. In this article, we report a case of combat-related PTSD with severe panic, suicidality, and agitation which responded favorably to a combination of ziprasidone, propranolol, and hydroxyzine. METHODS: An extensive literature search did not reveal any use of this combination, and there were few studies about each medication individually, with regard to PTSD...
January 2017: Military Medicine
https://www.readbyqxmd.com/read/28046858/su-f-i-68-longitudinal-neurochemical-changes-on-rat-prefrontal-cortex-of-single-prolonged-stress-model-by-using-proton-magnetic-resonance-spectroscopy-at-9-4t
#3
S-I Lim, K-H Song, C-H Yoo, D-C Woo, B-Y Choe
PURPOSE: Single prolonged stress (SPS) is an animal model of posttraumatic stress disorder (PTSD). However, it has not been known how PTSD develops from the first exposure to traumatic events and neurochemical differences between acute/single stress and PTSD-triggering stress. Therefore, the object of this study is to determine time-dependent neurochemical changes in prefrontal cortex (PFC) of rats using in vivo proton magnetic resonance spectroscopy (1H-MRS). METHODS: Male Sprague-Dawley rats (n=14; body weight=200-220g) were used...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045980/long-term-effects-of-acute-stress-on-the-prefrontal-limbic-system-in-the-healthy-adult
#4
Yu Li, Xin Hou, Dongtao Wei, Xue Du, Qinglin Zhang, Guangyuan Liu, Jiang Qiu
Most people are exposed to at least one traumatic event during the course of their lives, but large numbers of people do not develop posttraumatic stress disorders. Although previous studies have shown that repeated and chronic stress change the brain's structure and function, few studies have focused on the long-term effects of acute stressful exposure in a nonclinical sample, especially the morphology and functional connectivity changes in brain regions implicated in emotional reactivity and emotion regulation...
2017: PloS One
https://www.readbyqxmd.com/read/28030485/combat-amputees-health-related-quality-of-life-and-psychological-outcomes-a-brief-report-from-the-wounded-warrior-recovery-project
#5
Susan I Woodruff, Michael R Galarneau, Daniel I Sack, Cameron T McCabe, Judy L Dye
BACKGROUND: This study extends what is known about long-term health-related quality of life (HrQoL) and other psychosocial outcomes (i.e., depression, posttraumatic stress disorder [PTSD]) among US military combat amputees serving in Operation Enduring Freedom, Operation Iraqi Freedom, and Operation New Dawn. METHODS: A total of 63 combat amputees were identified from the Wounded Warrior Recovery Project (WWRP), a study assessing long-term self-reported HrQoL and psychological outcomes among those wounded during military service...
December 23, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28025095/a-cross-species-study-of-heterogeneity-in-fear-extinction-learning-in-relation-to-fkbp5-variation-and-expression-implications-for-the-acute-treatment-of-posttraumatic-stress-disorder
#6
Isaac R Galatzer-Levy, Raül Andero, Takehito Sawamura, Tanja Jovanovic, Santiago Papini, Kerry J Ressler, Seth Davin Norrholm
Deficits in fear extinction learning are hypothesized to underlie the development of posttraumatic stress disorder (PTSD). Such deficits may, in part, be due to genetic and epigenetic variation in the stress related gene FKBP5. Conversely, altering FKBP5 epigenetic responses during memory consolidation may rescue extinction deficits making it a target for acute intervention to prevent the development of PTSD. Study 1 (Humans) examines if FKBP5 single nucleotide polymorphisms (SNPs) and PTSD symptom domains (re-experiencing, avoidance/numbing, hyperarousal) are associated with abnormal fear extinction phenotypes identified using latent growth mixture modeling (LGMM)...
December 23, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/28002832/acute-and-chronic-posttraumatic-stress-symptoms-in-the-emergence-of-posttraumatic-stress-disorder-a-network-analysis
#7
Richard A Bryant, Mark Creamer, Meaghan O'Donnell, David Forbes, Alexander C McFarlane, Derrick Silove, Dusan Hadzi-Pavlovic
Importance: Little is understood about how the symptoms of posttraumatic stress develop over time into the syndrome of posttraumatic stress disorder (PTSD). Objective: To use a network analysis approach to identify the nature of the association between PTSD symptoms in the acute phase after trauma and the chronic phase. Design, Setting, and Participants: A prospective cohort study enrolled 1138 patients recently admitted with traumatic injury to 1 of 4 major trauma hospitals across Australia from March 13, 2004, to February 26, 2006...
December 14, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27997466/prevalence-of-depression-and-posttraumatic-stress-disorder-after-acute-orthopaedic-trauma-a-systematic-review-and-meta-analysis
#8
Stefano Muscatelli, Hayley Spurr, Nathan N OʼHara, Lyndsay M OʼHara, Sheila A Sprague, Gerard P Slobogean
OBJECTIVES: This study aims to systematically assess the existing literature and to derive a pooled estimate of the prevalence of depression and posttraumatic stress disorder (PTSD) in adult patients after acute orthopaedic trauma. DATA SOURCES: A comprehensive search of databases, including MEDLINE, Embase, PsycINFO, and Cochrane Central Register of Controlled Trials databases was conducted through June 2015. STUDY SELECTION: We included studies that assessed the prevalence of depression or PTSD in patients who experienced acute orthopaedic trauma to the appendicular skeleton or pelvis...
January 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/27941578/trauma-and-autonomic-dysregulation-episodic-versus-systemic-negative-affect-underlying-cardiovascular-risk-in-posttraumatic-stress-disorder
#9
Paul A Dennis, Nathan A Kimbrel, Andrew Sherwood, Patrick S Calhoun, Lana L Watkins, Michelle F Dennis, Jean C Beckham
OBJECTIVE: Posttraumatic stress disorder (PTSD) has been linked to elevated heart rate (HR) and reduced heart-rate variability (HRV) in cross-sectional research. Recent evidence suggests that this link may be driven by individual differences in autonomic arousal associated with momentary negative affect (NA). Using ecological momentary assessment (EMA) of NA and minute-to-minute HR/HRV monitoring, we examined whether NA-related HR/HRV mediated the association of PTSD symptom severity with 24-hour HRV and endothelial functioning...
December 9, 2016: Psychosomatic Medicine
https://www.readbyqxmd.com/read/27932983/cannabidiol-regulation-of-learned-fear-implications-for-treating-anxiety-related-disorders
#10
Regimantas Jurkus, Harriet L L Day, Francisco S Guimarães, Jonathan L C Lee, Leandro J Bertoglio, Carl W Stevenson
Anxiety and trauma-related disorders are psychiatric diseases with a lifetime prevalence of up to 25%. Phobias and post-traumatic stress disorder (PTSD) are characterized by abnormal and persistent memories of fear-related contexts and cues. The effects of psychological treatments such as exposure therapy are often only temporary and medications can be ineffective and have adverse side effects. Growing evidence from human and animal studies indicates that cannabidiol, the main non-psychotomimetic phytocannabinoid present in Cannabis sativa, alleviates anxiety in paradigms assessing innate fear...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27905829/post-traumatic-stress-disorder-dimensions-and-asthma-morbidity-in-world-trade-center-rescue-and-recovery-workers
#11
Irina Mindlis, Esperanza Morales-Raveendran, Emily Goodman, Kevin Xu, Clara Vila-Castelar, Kristine Keller, Ginger Crawford, Shynah James, Craig Katz, Laura E Crowley, Rafael E de la Hoz, Steven Markowitz, Juan P Wisnivesky
Objective Using data from a cohort of World Trade Center (WTC) rescue and recovery workers with asthma, we assessed whether meeting criteria for post-traumatic stress disorder (PTSD), sub- PTSD and for specific PTSD symptom dimensions are associated with increased asthma morbidity. Methods Participants underwent a Structured Clinical Interview for Diagnostic and Statistical Manual to assess presence of PTSD following DSM-IV criteria during in-person interviews between December 2013 and April 2015. We defined sub-threshold PTSD as meeting criteria for two of three symptom dimensions: re-experiencing, avoidance, or hyper-arousal...
December 1, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27859619/treatment-of-adolescent-ptsd-the-impact-of-prolonged-exposure-versus-client-centered-therapy-on-co-occurring-emotional-and-behavioral-problems
#12
Laurie Zandberg, Antonia N Kaczkurkin, Carmen P McLean, Leslie Rescorla, Elna Yadin, Edna B Foa
The present study evaluated secondary emotional and behavioral outcomes among adolescents who received prolonged exposure (PE-A) or client-centered therapy (CCT) for posttraumatic stress disorder (PTSD) in a randomized controlled trial. Participants were 61 adolescent girls (age: M = 15.33, SD = 1.50 years) with sexual abuse related PTSD seeking treatment at a community mental health clinic. Multilevel modeling was employed to evaluate group differences on the Youth Self-Report (YSR) over acute treatment and 12-month follow-up...
December 2016: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/27849494/inpatient-trauma-focused-treatment-for-veterans-implementation-and-evaluation-of-patient-perceptions-and-outcomes-of-an-integrated-evidence-based-treatment-approach
#13
Deleene S Menefee, Wendy S Leopoulos, Jana K Tran, Ellen Teng, Jill Wanner, Elisabeth Wilde, Stephen McCauley, Susan X Day
BACKGROUND: Practice guidelines for post-traumatic stress disorder (PTSD) treatment suggest that inpatient care may be warranted when the severity of the clinical presentation is marred with significant concerns about suicidality and psychiatric comorbidity. Yet, limited guidance exists on conducting trauma-focused treatment in acute hospital settings beyond the traditional medical or stabilization model. OBJECTIVE: The purpose of this current article is to describe and evaluate the integration of evidence-based treatments (EBTs) for PTSD implemented in two gender-specific, Veterans Affairs inpatient programs...
November 2016: Military Medicine
https://www.readbyqxmd.com/read/27835714/posttraumatic-stress-disorder-in-young-children-3-years-posttrauma-prevalence-and-longitudinal-predictors
#14
Richard Meiser-Stedman, Patrick Smith, William Yule, Edward Glucksman, Tim Dalgleish
OBJECTIVE: Age-appropriate criteria for posttraumatic stress disorder (PTSD) in young children have been established. The present study investigated the long-term course of such PTSD and its predictors in young children. METHODS: Young children (aged 2-10 years) and parents/caregivers who had attended emergency departments after motor vehicle collisions (MVCs) between May 2004 and November 2005 were assessed at 2 to 4 weeks and 6 months post-MVC; 71 families were re-interviewed 3 years post-MVC...
November 8, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27830378/-the-diagnostic-relevance-of-cbcl-and-ysr-in-diagnosing-ptsd-in-adolescence
#15
Sabine Völkl-Kernstock, Katrin Skala, Sophie Klomfar, Oswald D Kothgassner
BACKGROUND: The present study sought to examine the symptomatology of children and adolescents with a history of trauma experience of using the German versions of Child Behavior Checklist (CBCL) and Youth Self Report (YSR). We pursue the question to what extent symptoms differ among adolescents with and without posttraumatic stress disorder (PTSD). A further objective is comparing self-assessment of the children and adolescents with the rating of their parents or caregivers. METHODS: Overall N = 41 patients, aged 11-18 years, and one caregiver of each patient were surveyed...
December 2016: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
https://www.readbyqxmd.com/read/27821576/endogenously-released-neuropeptide-y-suppresses-hippocampal-short-term-facilitation-and-is-impaired-by-stress-induced-anxiety
#16
Qin Li, Aundrea F Bartley, Lynn E Dobrunz
: Neuropeptide Y (NPY) has robust anxiolytic properties and is reduced in patients with anxiety disorders. However, mechanisms by which NPY modulates circuit function to reduce anxiety behavior are not known. Anxiolytic effects of NPY are mediated in the CA1 region of hippocampus, and NPY injection into hippocampus alleviates anxiety symptoms in the Predator Scent Stress model of stress-induced anxiety. The mechanisms that regulate NPY release, and its effects on CA1 synaptic function, are not fully understood...
November 7, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27799776/hyperbaric-oxygen-therapy-as-a-potential-treatment-for-post-traumatic-stress-disorder-associated-with-traumatic-brain-injury
#17
REVIEW
David J Eve, Martin R Steele, Paul R Sanberg, Cesar V Borlongan
Traumatic brain injury (TBI) describes the presence of physical damage to the brain as a consequence of an insult and frequently possesses psychological and neurological symptoms depending on the severity of the injury. The recent increased military presence of US troops in Iraq and Afghanistan has coincided with greater use of improvised exploding devices, resulting in many returning soldiers suffering from some degree of TBI. A biphasic response is observed which is first directly injury-related, and second due to hypoxia, increased oxidative stress, and inflammation...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27796710/posttraumatic-stress-disorder-symptomatology-in-the-course-of-allogeneic-hsct-a-prospective-study
#18
Peter Esser, Katharina Kuba, Angela Scherwath, Lena Schirmer, Frank Schulz-Kindermann, Andreas Dinkel, Friedrich Balck, Uwe Koch, Nicolaus Kröger, Heide Götze, Anja Mehnert
PURPOSE: Despite the life-threatening character of allogeneic hematopoietic stem cell transplantation (allogeneic HSCT), very few longitudinal research exists on posttraumatic stress disorder (PTSD) symptomatology in this patient group. We investigated prevalence, temporal course and predictors of PTSD symptomatology in this population. METHODS: Patients were assessed before conditioning (T0), 100 days (T1), and 12 months after HSCT (T2). PTSD symptomatology was measured with the PTSD Checklist-Civilian Version...
October 31, 2016: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/27750357/-psychiatric-and-psychotherapeutic-care-of-refugees-by-reference-of-a-large-psychiatric-care-hospital-in-western-germany
#19
Jonas Schaffrath, Mario Schmitz-Buhl, Ali Kemal Gün, Euphrosyne Gouzoulis-Mayfrank
Medical and psychological care of refugees is among the most important current challenges in German health politics. Work with patients from this heterogeneous group who have often faced severe stress before, during and after their migration is currently based on a thin data foundation. Based on introductory information on current knowledge concerning psychiatric morbidity of refugees this article presents the psychiatric care of refugees at LVR Clinics Cologne - a psychiatric specialty hospital situated in North Rhine-Westphalia, Germany...
October 17, 2016: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/27745536/enhancing-the-reach-of-cognitive-behavioral-therapy-targeting-posttraumatic-stress-in-acute-care-medical-settings
#20
Doyanne Darnell, Stephen O'Connor, Amy Wagner, Joan Russo, Jin Wang, Leah Ingraham, Kirsten Sandgren, Douglas Zatzick
OBJECTIVE: Injured patients presenting to acute care medical settings have high rates of posttraumatic stress disorder (PTSD) and comorbidities, such as depression and substance use disorders. Integrating behavioral interventions that target symptoms of PTSD and comorbidities into the acute care setting can overcome common barriers to obtaining mental health care. This study examined the feasibility and acceptability of embedding elements of cognitive-behavioral therapy (CBT) in the delivery of routine postinjury care management...
October 17, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
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