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Willemijn van Eldik, Brigit den Adel, Jantine Monshouwer-Kloots, Daniela Salvatori, Saskia Maas, Ingeborg van der Made, Esther E Creemers, Derk Frank, Norbert Frey, Nicky Boontje, Jolanda van der Velden, Paul Steendijk, Christine Mummery, Robert Passier, Abdelaziz Beqqali
AIMS: The Z-disc is a crucial structure of the sarcomere and is implicated in mechanosensation/transduction. Dysregulation of Z-disc proteins often result in cardiomyopathy. We have previously shown that the Z-disc protein Cytoskeletal Heart-enriched Actin-associated Protein (CHAP) is essential for cardiac and skeletal muscle development. Furthermore, the CHAP gene has been associated with atrial fibrillation in humans. Here, we studied the misregulated expression of CHAP isoforms in heart disease...
2017: PloS One
Dale Guenter, Ricardo Angeles, Janusz Kaczorowski, Gina Agarwal, Fortunato L Cristobal, Rosemarie Arciaga, John F Smith, Pattapong Kessomboon, Faical Jarraya, Rodelin Agbulos, Floro Dave Arnuco, Jerome Barrera, Susan Dimitry, Elgie Gregorio, Servando Halili, Norvie T Jalani, Nusaraporn Kessomboon, Maita Ladeza, Lisa Dolovich
The Community Health Assessment Program-Philippines (CHAP-P) is an international collaboration of investigators whose aim is to adapt a previously proven Canadian community-based cardiovascular awareness and prevention intervention to the Philippines and other low-middle-income countries. Choosing a method of blood pressure measurement for the research program presents a challenge. There is increasing consensus globally that blood pressure measurement with automated devices is preferred. Recommendations from low-middle-income countries, including the Philippines, are less supportive of automated blood pressure devices...
May 30, 2017: Journal of Clinical Hypertension
Christi A Patten, Carrie A Bronars, Matthew Scott, Rahnia Boyer, Harry Lando, Matthew M Clark, Kenneth Resnicow, Paul A Decker, Tabetha A Brockman, Agnes Roland, Marcelo Hanza
This study assessed health behaviors and preferences for wellness programs among employees of a worksite serving Alaska Native-people. Village-based Community Health Aides/Practitioners (CHA/Ps) were compared with all other employees on health indicators and program preferences. Using a cross-sectional design, all 1290 employees at the Yukon Kuskokwim Health Corporation (YKHC) in Western Alaska were invited in 2015 to participate in a 30-item online survey. Items assessed health behaviors, perceived stress, resiliency, and preferences for wellness topics and program delivery formats...
June 2017: Preventive Medicine Reports
G Agarwal, R Angeles, M Pirrie, F Marzanek, B McLeod, J Parascandalo, L Dolovich
BACKGROUND: Seniors living in subsidized housing have lower income, poorer health, and increased risk for cardiometabolic diseases and falls. Seniors also account for more than one third of calls to Emergency Medical Services (EMS). This study examines the effectiveness of the Community Health Assessment Program through EMS (CHAP-EMS) in reducing blood pressure, diabetes risk, and EMS calls. METHODS: Paramedics on modified duty (e.g. injured) conducted weekly, one-on-one drop-in sessions in a common area of one subsidized senior's apartment building in Hamilton, Ontario...
March 9, 2017: BMC Emergency Medicine
Elliot G Arsoniadis, Yen-Yi Ho, Genevieve B Melton, Robert D Madoff, Chap Le, Mary R Kwaan
Background: Previous reports on racial disparities in the treatment of Crohn's disease [CD] in African American [AA] patients have shown differences in both medical and surgical treatments in this population. No study thus far has examined the effect of AA race on outcomes after surgery for CD. Methods: Utilizing the National Surgical Quality Improvement Program [NSQIP] Participant User File [PUF] for the years 2005-2013, we examined the effect of AA race on postoperative complications in patients with CD undergoing intestinal surgery...
April 1, 2017: Journal of Crohn's & Colitis
Madison Brydges, Margaret Denton, Gina Agarwal
BACKGROUND: Expanded roles for paramedics, commonly termed community paramedicine, are becoming increasingly common. Paramedics working in community paramedicine roles represent a distinct departure away from the traditional emergency paradigm of paramedic services. Despite this, little research has addressed how community paramedics are perceived by their clients. METHODS: This study took an interpretivist qualitative approach to examine participants' perceptions of paramedics providing a community paramedicine program, named the Community Health Assessment Program through Emergency Medical Services (CHAP-EMS)...
August 24, 2016: BMC Health Services Research
Chin-Chi Chang, Imran Khan, Kun-Lin Tsai, Hongchun Li, Lee-Wei Yang, Ruey-Hwang Chou, Chin Yu
Human S100A9 (Calgranulin B) is a Ca(2+)-binding protein, from the S100 family, that often presents as a homodimer in myeloid cells. It becomes an important mediator during inflammation once calcium binds to its EF-hand motifs. Human RAGE protein (receptor for advanced glycation end products) is one of the target-proteins. RAGE binds to a hydrophobic surface on S100A9. Interactions between these proteins trigger signal transduction cascades, promoting cell growth, proliferation, and tumorigenesis. Here, we present the solution structure of mutant S100A9 (C3S) homodimer, determined by multi-dimensional NMR experiments...
November 2016: Biochimica et Biophysica Acta
Shahin Shooshtari, Beverley Temple, Celeste Waldman, Sneha Abraham, Héléne Ouellette-Kuntz, Nicholas Lennox
BACKGROUND: No standardized tool is used in Canada for comprehensive health assessments of adults with intellectual disabilities. This study was conducted to determine the feasibility of implementing the Comprehensive Health Assessment Program (CHAP) in Manitoba, Canada. METHOD: This was a qualitative study using a purposive sample of physicians, nurse practitioners, support workers and families. Data were collected through individual interviews and focus groups and were analysed using content analysis...
June 9, 2016: Journal of Applied Research in Intellectual Disabilities: JARID
Mieke L van Driel, Simon Morgan, Amanda Tapley, Lawrie McArthur, Patrick McElduff, Lucy Yardley, Anthea Dallas, Laura Deckx, Katie Mulquiney, Joshua S Davis, Andrew Davey, Kim Henderson, Paul Little, Parker J Magin
BACKGROUND: Australian General Practitioners (GPs) are generous prescribers of antibiotics, prompting concerns including increasing antimicrobial resistance in the community. Recent data show that GPs in vocational training have prescribing patterns comparable with the high prescribing rate of their established GP supervisors. Evidence-based guidelines consistently advise that antibiotics are not indicated for uncomplicated upper respiratory tract infections (URTI) and are rarely indicated for acute bronchitis...
June 6, 2016: BMC Family Practice
Lehana Thabane, Janusz Kaczorowski, Lisa Dolovich, Larry W Chambers, Lawrence Mbuagbaw
UNLABELLED: Knowledge translation (KT) involves implementation of evidence-based strategies and guidelines into practice to improve the process of care and health outcomes for patients. Findings from pragmatic trials may be used in KT to provide patients, healthcare providers and policymakers with information to optimize healthcare decisions based on how a given strategy or intervention performs under the real world conditions. However, pragmatic trials have been criticized for having the following problems: i) high rates of loss to follow-up; ii) nonadherence to study intervention; iii) unblinded treatment and patient self-assessment, which can potentially create bias; iv) being less perfect experiments than efficacy trials; v) sacrificing internal validity to achieve generalizability; and vi) often requiring large sample sizes to detect small treatment effects in heterogeneous populations...
2015: Trials
Gina Agarwal, Ricardo N Angeles, Beatrice McDonough, Brent McLeod, Francine Marzanek, Melissa Pirrie, Lisa Dolovich
BACKGROUND: Older adults have higher risk of developing cardiovascular disease, diabetes and falls, leading to costly emergency medical service (EMS) calls and emergency room visits. We developed the Community Health Assessment Program through EMS (CHAP-EMS) that focuses on health promotion/prevention of hypertension and diabetes, links with primary care practitioners, targets seniors living in subsidized housing, and aims to reduce morbidity from these conditions, thereby reducing EMS calls...
2015: BMC Research Notes
Sarah Redding, Elizabeth Conrey, Kyle Porter, John Paulson, Karen Hughes, Mark Redding
The evidence is limited on the effectiveness of home visiting care coordination in addressing poor birth outcome, including low birth weight (LBW). The Community Health Access Project (CHAP) utilizes community health workers (CHWs) to identify women at risk of having poor birth outcomes, connect them to health and social services, and track each identified health or social issue to a measurable completion. CHWs are trained individuals from the same highest risk communities. The CHAP Pathways Model is used to track each maternal health and social service need to resolution and CHWs are paid based upon outcomes...
March 2015: Maternal and Child Health Journal
Saeed Karimi, Mahmoud Keyvanara, Mohsen Hosseini, Marzie Jafarian Jazi, Elahe Khorasani
BACKGROUND: Today, much attention has been paid to the patient role as the central factor in the management of their own health. It is focused on the issue that the patient has a more critical role compared with the health-care provider in controlling the patient own health. defines health literacy as the degree to which individuals have the capacity to obtain, process, and understand basic health information and services needed to make appropriate health decisions. OBJECTIVE: The objective of this study was to determine health literacy, health status, healthcare utilization and the relationship between them in 18 - 64 years old people in Isfahan...
2014: Journal of Education and Health Promotion
Chenglin Ye, Gary Foster, Janusz Kaczorowski, Larry W Chambers, Ricardo Angeles, Francine Marzanek-Lefebvre, Stephanie Laryea, Lehana Thabane, Lisa Dolovich
BACKGROUND: Hypertension is an important and modifiable cardiovascular risk factor that remains under-detected and under-treated, especially in the older individuals. Community-led interventions that integrate primary health care and local resources are promising approaches to improve awareness and management of hypertension and other cardiovascular risk factors. We aimed to evaluate the effect of a community-based Cardiovascular Health Awareness Program (CHAP) on participants' blood pressure...
2013: BMC Public Health
E Katzmann, M Eibauer, W Lin, Y Pan, J M Plitzko, D Schüler
Magnetotactic bacteria (MTB) align along the Earth's magnetic field by the activity of intracellular magnetosomes, which are membrane-enveloped magnetite or greigite particles that are assembled into well-ordered chains. Formation of magnetosome chains was found to be controlled by a set of specific proteins in Magnetospirillum gryphiswaldense and other MTB. However, the contribution of abiotic factors on magnetosome chain assembly has not been fully explored. Here, we first analyzed the effect of growth conditions on magnetosome chain formation in M...
December 2013: Applied and Environmental Microbiology
Onuma Chumsakul, Kensuke Nakamura, Tetsuya Kurata, Tomoaki Sakamoto, Jon L Hobman, Naotake Ogasawara, Taku Oshima, Shu Ishikawa
Accurate identification of the DNA-binding sites of transcription factors and other DNA-binding proteins on the genome is crucial to understanding their molecular interactions with DNA. Here, we describe a new method: Genome Footprinting by high-throughput sequencing (GeF-seq), which combines in vivo DNase I digestion of genomic DNA with ChIP coupled with high-throughput sequencing. We have determined the in vivo binding sites of a Bacillus subtilis global regulator, AbrB, using GeF-seq. This method shows that exact DNA-binding sequences, which were protected from in vivo DNase I digestion, were resolved at a comparable resolution to that achieved by in vitro DNase I footprinting, and this was simply attained without the necessity of prediction by peak-calling programs...
August 2013: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
Tina Karwalajtys, Janusz Kaczorowski, Larry W Chambers, Heather Hall, Beatrice McDonough, Lisa Dolovich, Rolf Sebaldt, Lynne Lohfeld, Brian Hutchison
PURPOSE: To determine the feasibility of a community-wide approach integrated with primary care (Cardiovascular Health Awareness Program [CHAP]) to promote monitoring of blood pressure (BP) and awareness of cardiovascular disease risk. DESIGN: Demonstration project. SETTING: Two midsized Ontario communities. PARTICIPANTS: Community-dwelling seniors. INTERVENTION: CHAP sessions were offered in pharmacies and promoted to seniors using advertising and personalized letters from physicians...
March 2013: American Journal of Health Promotion: AJHP
Ron Goeree, Camilla von Keyserlingk, Natasha Burke, Jing He, Janusz Kaczorowski, Larry Chambers, Lisa Dolovich, J Michael Paterson, Brandon Zagorski
BACKGROUND: Cardiovascular disease (CVD) is a leading cause of hospitalizations, death, and health care costs. Although studies have shown that modifying CVD risk factors at the patient level improves patient prognosis, the effect of community-wide interventions at the population level has been uncertain. OBJECTIVE: To evaluate the resource use and cost consequences of a community-wide Cardiovascular Health Awareness Program (CHAP). METHODS: Thirty-nine medium-sized communities in Ontario, Canada, participated in a community cluster randomized controlled trial stratified by population size and geographic location...
January 2013: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Nicholas Lennox, Robert Ware, Suzanne Carrington, Michael O'Callaghan, Gail Williams, Lyn McPherson, Chris Bain
BACKGROUND: Adolescents with intellectual disability often have poor health and healthcare. This is partly as a consequence of poor communication and recall difficulties, and the possible loss of specialised paediatric services. METHODS/DESIGN: A cluster randomised trial was conducted with adolescents with intellectual disability to investigate a health intervention package to enhance interactions among adolescents with intellectual disability, their parents/carers, and general practitioners (GPs)...
September 7, 2012: BMC Public Health
N G Lennox, C E Brolan, J Dean, R S Ware, F M Boyle, M Taylor Gomez, K van Dooren, C Bain
BACKGROUND: Health assessments for people with intellectual disability have been implemented in the UK, New Zealand and Australia, and have led to improved health outcomes. The Comprehensive Health Assessment Program (CHAP) has been shown to improve the health of people with intellectual disability. Similar to other health assessments, it is designed to address healthcare needs, many of which are often overlooked in this population, through better communication between the general practitioner (GP), support worker and the person with intellectual disability...
October 2013: Journal of Intellectual Disability Research: JIDR
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