Analia G Novero, Paulina Torres Rodríguez, José L De la Vega Beltrán, Liz J Schiavi-Ehrenhaus, Guillermina M Luque, Micaela Carruba, Cintia Stival, Iñaki Gentile, Carla Ritagliati, Celia M Santi, Takuya Nishigaki, Diego Krapf, Mariano G Buffone, Alberto Darszon, Claudia L Treviño, Dario Krapf
UNLABELLED: Sperm capacitation, crucial for fertilization, occurs in the female reproductive tract and can be replicated in vitro using a medium rich in bicarbonate, calcium, and albumin. These components trigger the cAMP-PKA signaling cascade, proposed to promote hyperpolarization of the mouse sperm plasma membrane through activation of SLO3 K + channel. Hyperpolarization is a hallmark of capacitation: proper membrane hyperpolarization renders higher in vitro fertilizing ability, while Slo3 KO mice are infertile...
March 6, 2024: bioRxiv