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JOURNAL ARTICLE
Jesus Ruiz Ramos, Aitor Alquézar-Arbé, Ana Juanes Borrego, Guillermo Burillo Putze, Sira Aguiló, Javier Jacob, Cesáreo Fernández, Pere Llorens, Francisco de Borja Quero Espinosa, Susana Gordo Remartinez, Rocio Hernando González, Miguel Moreno Martín, Sara Sánchez Aroca, Alicia Sara Knabe, Rebeca González González, Marina Carrión Fernández, Alberto Artieda Larrañaga, Maria Adroher Muñoz, Jeong-Uh Hong Cho, María Teresa Escolar Martínez Berganza, Sara Gayoso Martín, Goretti Sánchez Sindín, Martina Silva Penas, Bárbara Gómez Y Gómez, Roser Arenos Sambro, Juan González Del Castillo, Òscar Miró
BACKGROUND: Polypharmacy is a growing phenomenon among elderly individuals. However, there is little information about the frequency of polypharmacy among the elderly population treated in emergency departments (EDs) and its prognostic effect. This study aims to determine the prevalence and short-term prognostic effect of polypharmacy in elderly patients treated in EDs. METHODS: A retrospective analysis of the Emergency Department Elderly in Needs (EDEN) project's cohort was performed...
2024: Therapeutic Advances in Drug Safety
#22
JOURNAL ARTICLE
Eric Jorge García-Lamberechts, Manuel Fuentes Ferrer, Cesáreo Fernández-Alonso, Guillermo Burillo-Putze, Sira Aguiló, Aitor Alquezar-Arbé, Francisco Javier Montero-Pérez, Javier Jacob, Pascual Piñera Salmerón, Manuel Salido Mota, Maria José Marchena, Alba Martínez Alonso, Ana Chacón García, Cristina Güemes de la Iglesia, Osvaldo Jorge Troiano Ungerer, Patricia Eiroa-Hernández, Patricia Parra-Esquivel, Paula Lázaro Aragüés, Patricia Gantes Nieto, Sandra Cuerpo Cardeñosa, Cristina Chacón García, Leticia Serrano Lázaro, María Caballero Martínez, Lara Guillen, Rocío Muñoz Martos, Juan González Del Castillo, Òscar Miró
OBJECTIVE: To analyze the prognostic accuracy of the scores NEWS, qSOFA, GYM used in hospital emergency department (ED) in the assessment of elderly patients who consult for an infectious disease. METHODS: Data from the EDEN (Emergency Department and Elderly Need) cohort were used. This retrospective cohort included all patients aged ≥65 years seen in 52 Spanish EDs during two weeks (from 1-4-2019 to 7-4-2019 and 30/3/2020 to 5/4/2020) with an infectious disease diagnosis in the emergency department...
January 30, 2024: Enfermedades infecciosas y microbiologia clinica
#23
JOURNAL ARTICLE
Konstantinos N Fountoulakis, Gregory Karakatsoulis, Seri Abraham, Kristina Adorjan, Helal Uddin Ahmed, Renato D Alarcón, Kiyomi Arai, Sani Salihu Auwal, Michael Berk, Sarah Bjedov, Julio Bobes, Teresa Bobes-Bascaran, Julie Bourgin-Duchesnay, Cristina Ana Bredicean, Laurynas Bukelskis, Akaki Burkadze, Indira Indiana Cabrera Abud, Ruby Castilla-Puentes, Marcelo Cetkovich, Hector Colon-Rivera, Ricardo Corral, Carla Cortez-Vergara, Piirika Crepin, Domenico De Berardis, Sergio Zamora Delgado, David De Lucena, Avinash De Sousa, Ramona Di Stefano, Seetal Dodd, Livia Priyanka Elek, Anna Elissa, Berta Erdelyi-Hamza, Gamze Erzin, Martin J Etchevers, Peter Falkai, Adriana Farcas, Ilya Fedotov, Viktoriia Filatova, Nikolaos K Fountoulakis, Iryna Frankova, Francesco Franza, Pedro Frias, Tatiana Galako, Cristian J Garay, Leticia Garcia-Álvarez, Maria Paz García-Portilla, Xenia Gonda, Tomasz M Gondek, Daniela Morera González, Hilary Gould, Paolo Grandinetti, Arturo Grau, Violeta Groudeva, Michal Hagin, Takayuki Harada, Tasdik M Hasan, Nurul Azreen Hashim, Jan Hilbig, Sahadat Hossain, Rossitza Iakimova, Mona Ibrahim, Felicia Iftene, Yulia Ignatenko, Matias Irarrazaval, Zaliha Ismail, Jamila Ismayilova, Asaf Jakobs, Miro Jakovljević, Nenad Jakšić, Afzal Javed, Helin Yilmaz Kafali, Sagar Karia, Olga Kazakova, Doaa Khalifa, Olena Khaustova, Steve Koh, Svetlana Kopishinskaia, Korneliia Kosenko, Sotirios A Koupidis, Illes Kovacs, Barbara Kulig, Alisha Lalljee, Justine Liewig, Abdul Majid, Evgeniia Malashonkova, Khamelia Malik, Najma Iqbal Malik, Gulay Mammadzada, Bilvesh Mandalia, Donatella Marazziti, Darko Marčinko, Stephanie Martinez, Eimantas Matiekus, Gabriela Mejia, Roha Saeed Memon, Xarah Elenne Meza Martínez, Dalia Mickevičiūtė, Roumen Milev, Muftau Mohammed, Alejandro Molina-López, Petr Morozov, Nuru Suleiman Muhammad, Filip Mustač, Mika S Naor, Amira Nassieb, Alvydas Navickas, Tarek Okasha, Milena Pandova, Anca-Livia Panfil, Liliya Panteleeva, Ion Papava, Mikaella E Patsali, Alexey Pavlichenko, Bojana Pejuskovic, Mariana Pinto Da Costa, Mikhail Popkov, Dina Popovic, Nor Jannah Nasution Raduan, Francisca Vargas Ramírez, Elmars Rancans, Salmi Razali, Federico Rebok, Anna Rewekant, Elena Ninoska Reyes Flores, María Teresa Rivera-Encinas, Pilar Saiz, Manuel Sánchez de Carmona, David Saucedo Martínez, Jo Anne Saw, Görkem Saygili, Patricia Schneidereit, Bhumika Shah, Tomohiro Shirasaka, Ketevan Silagadze, Satti Sitanggang, Oleg Skugarevsky, Anna Spikina, Sridevi Sira Mahalingappa, Maria Stoyanova, Anna Szczegielniak, Simona Claudia Tamasan, Giuseppe Tavormina, Maurilio Giuseppe Maria Tavormina, Pavlos N Theodorakis, Mauricio Tohen, Eva Maria Tsapakis, Dina Tukhvatullina, Irfan Ullah, Ratnaraj Vaidya, Johann M Vega-Dienstmaier, Jelena Vrublevska, Olivera Vukovic, Olga Vysotska, Natalia Widiasih, Anna Yashikhina, Panagiotis E Prezerakos, Daria Smirnova
No abstract text is available yet for this article.
January 25, 2024: CNS Spectrums
#24
Michal Gafner, Leila Haddad, Rachna Gupta, Zvi Leibovitz, Itamar Zilberman Ron, Liat Ben-Sira, Stephanie Libzon, Liat Gindes, Eugen Boltshauser, Tally Lerman-Sagie
Hydrocephalus is rarely described in Joubert-Boltshauser syndrome (JBTS). The aim of this study was to investigate whether this association is a chance occurrence or potentially signifies a new phenotypic subtype. The databases of Wolfson Medical Center, Sourasky Medical Center, and EB's personal collection were reviewed. Records from an additional family were obtained from RG. The patients' medical records, prenatal ultrasounds, and magnetic resonance imaging were assessed. In addition, we reviewed the medical literature for the association of ventriculomegaly/hydrocephalus (VM/HC) in JBTS...
January 21, 2024: Developmental Medicine and Child Neurology
#25
JOURNAL ARTICLE
Abhilash Vijay Nair, Anmol Singh, Yashas Devasurmutt, S A Rahman, Utpal Shashikant Tatu, Dipshikha Chakravortty
Spermidine is a poly-cationic molecule belonging to the family of polyamines and is ubiquitously present in all organisms. Salmonella synthesizes, and harbours specialized transporters to import spermidine. A group of polyamines have been shown to assist in Salmonella Typhimurium's virulence and regulation of Salmonella pathogenicity Inslad 1 (SPI-1) genes and stress resistance; however, the mechanism remains elusive. The virulence trait of Salmonella depends on its ability to employ multiple surface structures to attach and adhere to the surface of the target cells before invasion and colonization of the host niche...
January 12, 2024: Microbiological Research
#26
JOURNAL ARTICLE
Alea Maurice Simbulan, Edward C Banico, Ella Mae Joy S Sira, Nyzar Mabeth O Odchimar, Fredmoore L Orosco
Despite being identified over a hundred years ago, there is still no commercially available vaccine for the highly contagious and deadly African swine fever virus (ASFV). This study used immunoinformatics for the rapid and inexpensive designing of a safe and effective multi-epitope subunit vaccine for ASFV. A total of 18,858 proteins from 100 well-annotated ASFV proteomes were screened using various computational tools to identify potential epitopes, or peptides capable of triggering an immune response in swine...
January 16, 2024: Scientific Reports
#27
JOURNAL ARTICLE
Alexandra Grote, Bar Piscon, Abigail L Manson, Boaz Adani, Helit Cohen, Jonathan Livny, Ashlee M Earl, Ohad Gal-Mor
Several bacterial pathogens, including Salmonella enterica, can cause persistent infections in humans by mechanisms that are poorly understood. By comparing genomes of isolates longitudinally collected from 256 prolonged salmonellosis patients, we identified repeated mutations in global regulators, including the barA/sirA two-component regulatory system, across multiple patients and Salmonella serovars. Comparative RNA-seq analysis revealed that distinct mutations in barA/sirA led to diminished expression of Salmonella pathogenicity islands 1 and 4 genes, which are required for Salmonella invasion and enteritis...
January 10, 2024: Cell Host & Microbe
#28
JOURNAL ARTICLE
Yalan Li, Xiaoting Yang, Shanshan Zhao, Zixuan Zhang, Lu Bai, Pengcuo Zhaxi, Song Qu, Yan Zhao
Hongyuan yak milk is a protected geographical indication (PGI) product of rich nutritional value, which is popular among consumers. Stable isotope ratio analysis (SIRA) is an effective way to protect the authenticity of the geographical origin of PGI products, and it is crucial to study the factors affecting stable isotopes. Firstly, we proved that the SIRA could be used to identify the geographical origin of Hongyuan yak milk, and that the identification accuracy in combination with δ13 C and δ18 O was 100 %...
December 29, 2023: Food Chemistry
#29
JOURNAL ARTICLE
Lucie M Lindenbeck, Vanessa C Barra, Sira Dahlhaus, Silas Brand, Luca Wende, Björn B Beele, Nils H Schebb, Bruno V M Rodrigues, Adam Slabon
Replacing crude oil as the primary industrial source of carbon-based chemicals has become crucial for both environmental and resource sustainability reasons. In this scenario, wood arises as an excellent candidate, whilst depolymerization approaches have emerged as promising strategies to unlock the lignin potential as a resource in the production of high-value organic chemicals. However, many drawbacks, such as toxic solvents, expensive catalysts, high energy inputs, and poor product selectivity have represented major challenges to this task...
January 5, 2024: ChemSusChem
#30
JOURNAL ARTICLE
Urs Fisch, Anja L Jünger, Sira M Baumann, Saskia Semmlack, Gian Marco De Marchis, Stephan J Rüegg, Sabina Hunziker, Stephan Marsch, Raoul Sutter
BACKGROUND AND OBJECTIVES: To investigate the association between dose escalation of continuously administered IV anesthetics and its duration with short-term outcomes in adult patients treated for refractory status epilepticus (RSE). METHODS: Clinical and electroencephalographic data of patients with RSE without hypoxic-ischemic encephalopathy who were treated with anesthetics at a Swiss academic medical center from 2011 to 2019 were assessed. The frequency of anesthetic dose escalation (i...
January 23, 2024: Neurology
#31
JOURNAL ARTICLE
Thaneeya Samwang, Nozomi Morishita Watanabe, Yukihiro Okamoto, Sira Srinives, Hiroshi Umakoshi
Polypyrrole (PPy) is a conductive polymer known for its biocompatibility and ease of synthesis. Chemically polymerized PPy was synthesized in the presence of sodium dodecyl sulfate (SDS), showing correlations among chemical properties, physical morphology, and electrical properties. Focused synthesis parameters included the pyrrole (Py) concentration, SDS concentration, and ammonium persulfate (APS)/Py ratio. The addition of SDS during chemical polymerization influenced the physical morphology of PPy by altering the self-assembling process via micelle formation, yielding sheet-like morphologies...
December 26, 2023: ACS Omega
#32
JOURNAL ARTICLE
Cesáreo Fernandez Alonso, Manuel Fuentes Ferrer, Pere Llorens, Guillermo Burillo, Aitor Alquézar-Arbé, Javier Jacob, F Javier Montero-Pérez, Sira Aguiló, Vanesa Abad Cuñado, Lilia Amer Al Arud, Carmen Escudero Sánchez, Eduard Anton Poch Ferret, Jeong-Uh Hong Cho, María Teresa Escolar Martínez-Berganza, Sara Gayoso Martín, Goretti Sánchez Sindín, Azucena Prieto Zapico, María Carmen Petrus Rivas, Adriana Laura Doi Grande, Lluis Llauger, Celia Rodríguez Valles, Laura Marquez Quero, Ricardo Juárez González, Esther Ruescas, Fátima Fernández Salgado, Rafaela Rios Gallardo, María Ángeles de Juan Gómez, Marta Masid Barco, Juan González Del Castillo, Òscar Miró
INTRODUCTION: Mortality in emergency departments (ED) is not well known. This study aimed to assess the impact of the first-wave pandemic on deaths accounted in the ED of older patients with COVID and non-covid diseases. METHODS: We used data from the EDEN (Emergency Department and Elderly Needs) cohort (preCOVID period) and from the EDEN-Covid cohort (COVID period) that included all patients ≥65 years seen in 52 Spanish EDs from April 1 to 7, 2019, and March 30 to April 5, 2020, respectively...
December 29, 2023: Gerontology
#33
JOURNAL ARTICLE
Patiphan Wongklaew, Sira Sriswasdi, Ekapol Chuangsuwanich
MOTIVATION: The binding of a peptide antigen to a class I major histocompatibility complex (MHC) protein is part of a key process that lets the immune system recognize an infected cell or a cancer cell. This mechanism enabled the development of peptide-based vaccines that can activate the patient's immune response to treat cancers. Hence, the ability of accurately predict peptide-MHC binding is an essential component for prioritizing the best peptides for each patient. However, peptide-MHC binding experimental data for many MHC alleles are still lacking, which limited the accuracy of existing prediction models...
December 28, 2023: Bioinformatics
#34
JOURNAL ARTICLE
Marchand Etienne, Petit Fabienne, Alliot Fabrice, Blanchoud Hélène, Costantini David, Guigon Elodie, Martin Nicolas, Traore Sira, Goutte Aurélie
Urban freshwater ecosystems receive a wide array of organic pollutants through wastewater treatment plant (WWTP) discharges and agricultural runoff. Evaluating the fate and effects of antibiotics and pesticides can be a challenging task, especially the effects on freshwater vertebrates because of their abilities to metabolize and excrete these chemicals, and because of their high mobility and escape behavior when exposed to stressful environmental conditions. In the present study, 37 wild gudgeons (Gobio gobio) were caged for a period of up to 20 days, upstream and downstream of a WWTP effluent discharge in the Orge River (a tributary of the Seine River, France)...
December 20, 2023: Environmental Toxicology and Chemistry
#35
JOURNAL ARTICLE
Lourdes Artajona, Ana García-Martínez, Sira Aguiló, Guillermo Burillo-Putze, Aitor Alquézar-Arbé, Cesáreo Fernández, Amparo Fernández-Simón, María Fernández Cardona, María Teresa Maza Vera, Marta Iglesias Vela, Patricia Trenc Español, Manuel Salido Mota, Ángel García García, Carmen Lucena Aguilera, Ferran Llopis, Pablo Herrero, Adriana Laura Doi Grande, Leticia Serrano Lázaro, Ana Chacon García, José J Noceda Bermejo, Amanda Ibisate Cubillas, María José Hernández Martínez, Francesc Xavier Alemany González, Susana Sánchez Ramón, Begoña Espinosa Fernández, Juan González Del Castillo, Òscar Miró
OBJECTIVES: To determine whether income was associated with unexpected in-hospital mortality in older patients treated in Spanish public health system hospital emergency departments. MATERIAL AND METHODS: Fifty-one public health system hospital emergency departments in Spain voluntarily participated in the study. Together the hospitals covered 25% of the population aged 65 years or older included in all patient registers during a week in the pre-pandemic period (April 1-7, 2019) and a week during the COVID-19 pandemic (March 30 to April 5, 2020)...
December 2023: Emergencias: Revista de la Sociedad Española de Medicina de Emergencias
#36
JOURNAL ARTICLE
Patricia Eiroa-Hernández, Sebastián Matos, Sira Aguiló, Aitor Alquézar-Arbé, Javier Jacob, Cesáreo Fernández, Pere Llorens, Sandra Moreno Ruíz, Lidia Cuevas Jiménez, Aarati Vaswani-Bulchand, Montserrat Rodríguez-Cabrera, Maribel Coromoto Suárez Pineda, Sara Alegre Fresno, Ivet Gina Osorio, Ana María Puche Alcaraz, Jésica Mansilla Collado, Mónica Veguillas Benito, Francisco Chamorro, Lorenzo Álvarez Rocío, Valle Toro Gallardo, Fahd Beddar Chaib, Jorge Pedraza García, Francisco de Borja Quero Espinosa, Montserrat Jiménez Lucena, Gabriel Yepez León, Enrique González Revuelta, Sara Sánchez Aroca, Juan González Del Castillo, Guillermo Burillo-Putze, Òscar Miró
OBJECTIVES: The aims of this study in the Emergency Department and Elder Needs (EDEN) series were to explore associations between clinical variables on arrival at the ED (baseline) and the insertion of a bladder catheter, and the relation between catheterization and deterioration to a more complex or serious clinical state. MATERIAL AND METHODS: Included were all patients aged 65 years or older attended during 1 week in 52 Spanish EDs. Patients were grouped according to whether a bladder catheter was or was not inserted in the ED...
December 2023: Emergencias: Revista de la Sociedad Española de Medicina de Emergencias
#37
JOURNAL ARTICLE
Ali El-Ayoubi, Arsen Arakelyan, Moritz Klawitter, Luisa Merk, Siras Hakobyan, Irene Gonzalez-Menendez, Leticia Quintanilla-Fend, Per Sonne Holm, Wolfgang Mikulits, Matthias Schwab, Lusine Danielyan, Ulrike Naumann
Neural stem cells (NSCs) are considered to be valuable candidates for delivering a variety of anti-cancer agents, including oncolytic viruses, to brain tumors. However, owing to the previously reported tumorigenic potential of NSC cell lines after intranasal administration (INA), here we identified the human hepatic stellate cell line LX-2 as a cell type capable of longer resistance to replication of oncolytic adenoviruses (OAVs) as a therapeutic cargo, and that is non-tumorigenic after INA. Our data show that LX-2 cells can longer withstand the OAV XVir-N-31 replication and oncolysis than NSCs...
December 19, 2023: Molecular Oncology
#38
JOURNAL ARTICLE
Sininat Petcharat, Ananporn Supataragul, Piyapha Hirunpatrawong, Pattama Torvorapanit, Chonticha Klungthong, Piyawan Chinnawirotpisan, Sasiprapa Ninwattana, Nattakarn Thippamom, Leilani Paitoonpong, Gompol Suwanpimolkul, Watsamon Jantarabenjakul, Rome Buathong, Khajohn Joonlasak, Wudtichai Manasatienkij, Khwankamon Rattanatumhi, Napaporn Chantasrisawad, Nuntana Chumpa, Thomas S Cotrone, Stefan Fernandez, Sira Sriswasdi, Supaporn Wacharapluesadee, Opass Putcharoen
The emergence of Omicron as the fifth variant of concern within the SARS-CoV-2 pandemic in late 2021, characterized by its rapid transmission and distinct spike gene mutations, underscored the pressing need for cost-effective and efficient methods to detect viral variants, especially given their evolving nature. This study sought to address this need by assessing the effectiveness of two SARS-CoV-2 variant classification platforms based on RT-PCR and mass spectrometry. The primary aim was to differentiate between Delta, Omicron BA...
2023: Advances in Virology
#39
JOURNAL ARTICLE
Jahnabi Das, Shantanu K Mishra, Moirangthem N Singh, Mouchumee Bhattacharyya, Yanpothung Yanthan, Apurba K Kalita
Purpose This study compares the dosimetry and dose sparing of cardiac substructures in single isocenter and dual isocenter RapidArc™ (Varian Medical Systems, Palo Alto, California, United States) radiotherapy planning for synchronous bilateral breast cancer. Methodology Six synchronous bilateral breast cancer (SBBC) patients received adjuvant radiation with the prescribed dose of 40.05 Gy in 15 fractions to the planning target volume (PTV) without local lymph nodal regions. PTVs and organs at risk (OARs), including both lungs, esophagus, spinal cord, heart, and left anterior descending coronary artery (LAD), both atria and ventricles were contoured...
November 2023: Curēus
#40
JOURNAL ARTICLE
Bossmat Yehuda, Aviad Rabinowich, Daphna Link-Sourani, Netanell Avisdris, Ori Ben-Zvi, Bella Specktor-Fadida, Leo Joskowicz, Liat Ben-Sira, Elka Miller, Dafna Ben Bashat
BACKGROUND AND PURPOSE: The current imaging assessment of fetal brain gyrification is performed qualitatively and subjectively using sonography and MR imaging. A few previous studies have suggested methods for quantification of fetal gyrification based on 3D reconstructed MR imaging, which requires unique data and is time-consuming. In this study, we aimed to develop an automatic pipeline for gyrification assessment based on routinely acquired fetal 2D MR imaging data, to quantify normal changes with gestation, and to measure differences in fetuses with lissencephaly and polymicrogyria compared with controls...
November 22, 2023: AJNR. American Journal of Neuroradiology
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