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https://www.readbyqxmd.com/read/28899552/the-use-of-dissolvable-layered-double-hydroxide-components-in-an-in-situ-solid-phase-extraction-for-chromatographic-determination-of-tetracyclines-in-water-and-milk-samples
#1
Nattaphorn Phiroonsoontorn, Sira Sansuk, Yanawath Santaladchaiyakit, Supalax Srijaranai
This research presents a simple and green in situ solid phase extraction (is-SPE) combined with high-performance liquid chromatography (HPLC) for the simultaneous analysis of tetracyclines (TCs) including tetracycline, oxytetracycline, and chlortetracycline. In is-SPE, TCs were efficiently extracted through the precipitation formation of dissolvable layered double hydroxides (LDHs) by mixing the LDH components such as magnesium and aluminum ions (both in metal chloride salts) thoroughly in an alkaline sample solution...
September 4, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28898865/automatic-measurement-of-fetal-brain-development-from-magnetic-resonance-imaging-new-reference-data
#2
Daphna Link, Michael B Braginsky, Leo Joskowicz, Liat Ben Sira, Shaul Harel, Ariel Many, Ricardo Tarrasch, Gustavo Malinger, Moran Artzi, Cassandra Kapoor, Elka Miller, Dafna Ben Bashat
BACKGROUND: Accurate fetal brain volume estimation is of paramount importance in evaluating fetal development. The aim of this study was to develop an automatic method for fetal brain segmentation from magnetic resonance imaging (MRI) data, and to create for the first time a normal volumetric growth chart based on a large cohort. SUBJECTS AND METHODS: A semi-automatic segmentation method based on Seeded Region Growing algorithm was developed and applied to MRI data of 199 typically developed fetuses between 18 and 37 weeks' gestation...
September 13, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28884514/estrogenic-regulation-of-skeletal-muscle-proteome-a-study-of-premenopausal-women-and-postmenopausal-mz-cotwins-discordant-for-hormonal-therapy
#3
Eija K Laakkonen, Rabah Soliymani, Sira Karvinen, Jaakko Kaprio, Urho M Kujala, Marc Baumann, Sarianna Sipilä, Vuokko Kovanen, Maciej Lalowski
Female middle age is characterized by a decline in skeletal muscle mass and performance, predisposing women to sarcopenia, functional limitations, and metabolic dysfunction as they age. Menopausal loss of ovarian function leading to low circulating level of 17β-estradiol has been suggested as a contributing factor to aging-related muscle deterioration. However, the underlying molecular mechanisms remain largely unknown and thus far androgens have been considered as a major anabolic hormone for skeletal muscle...
September 7, 2017: Aging Cell
https://www.readbyqxmd.com/read/28878664/a-novel-prkar1a-mutation-identified-in-a-patient-with-isolated-primary-pigmented-nodular-adrenocortical-disease
#4
Sira Korpaisarn, Objoon Trachoo, Bhakbhoom Panthan, Rangsima Aroonroch, Ronnarat Suvikapakornkul, Chutintorn Sriphrapradang
Primary pigmented nodular adrenocortical disease (PPNAD) is a rare cause of Cushing syndrome, especially the isolated form without Carney complex, associated with germline mutations in PRKAR1A, the protein kinase A regulatory subunit type 1 alpha gene. We report a 31-year-old female who presented with secondary amenorrhea, cushingoid appearance, and hypertension without Carney complex. Biochemical laboratory examinations confirmed the ACTH-independent adrenal Cushing syndrome with negative Liddle test. A small right adrenal adenoma of 0...
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28815508/multipart-dna-assembly-using-site-specific-recombinases-from-the-large-serine-integrase-family
#5
Femi J Olorunniji, Christine Merrick, Susan J Rosser, Margaret C M Smith, W Marshall Stark, Sean D Colloms
Assembling multiple DNA fragments into functional plasmids is an important and often rate-limiting step in engineering new functions in living systems. Bacteriophage integrases are enzymes that carry out efficient recombination reactions between short, defined DNA sequences known as att sites. These DNA splicing reactions can be used to assemble large numbers of DNA fragments into a functional circular plasmid in a method termed serine integrase recombinational assembly (SIRA). The resulting DNA assemblies can easily be modified by further recombination reactions catalyzed by the same integrase in the presence of its recombination directionality factor (RDF)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28798215/spinal-and-paraspinal-plexiform-neurofibromas-in-patients-with-neurofibromatosis-type-1-a-novel-scoring-system-for-radiological-clinical-correlation
#6
M Mauda-Havakuk, B Shofty, S Ben-Shachar, L Ben-Sira, S Constantini, F Bokstein
BACKGROUND AND PURPOSE: Neurofibromatosis type 1 is a common tumor predisposition syndrome. The aim of this study was to characterize the radiologic presentation of patients with neurofibromatosis type 1 with widespread spinal disease and to correlate it to clinical presentation and outcome. MATERIALS AND METHODS: We conducted a historical cohort study of adult patients with neurofibromatosis type 1 with spinal involvement. Longitudinal clinical evaluation included pain and neurologic deficits...
August 10, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28750028/clinical-impact-of-a-targeted-next-generation-sequencing-gene-panel-for-autoinflammation-and-vasculitis
#7
Ebun Omoyinmi, Ariane Standing, Annette Keylock, Fiona Price-Kuehne, Sonia Melo Gomes, Dorota Rowczenio, Sira Nanthapisal, Thomas Cullup, Rodney Nyanhete, Emma Ashton, Claire Murphy, Megan Clarke, Helena Ahlfors, Lucy Jenkins, Kimberly Gilmour, Despina Eleftheriou, Helen J Lachmann, Philip N Hawkins, Nigel Klein, Paul A Brogan
BACKGROUND: Monogenic autoinflammatory diseases (AID) are a rapidly expanding group of genetically diverse but phenotypically overlapping systemic inflammatory disorders associated with dysregulated innate immunity. They cause significant morbidity, mortality and economic burden. Here, we aimed to develop and evaluate the clinical impact of a NGS targeted gene panel, the "Vasculitis and Inflammation Panel" (VIP) for AID and vasculitis. METHODS: The Agilent SureDesign tool was used to design 2 versions of VIP; VIP1 targeting 113 genes, and a later version, VIP2, targeting 166 genes...
2017: PloS One
https://www.readbyqxmd.com/read/28736061/short-term-reconsultation-hospitalisation-and-death-rates-after-discharge-from-the-emergency-department-in-patients-with-acute-heart-failure-and-analysis-of-the-associated-factors-the-altur-ica-study
#8
Òscar Miró, Víctor Gil, Francisco Javier Martín-Sánchez, Pablo Herrero, Javier Jacob, Carolina Sánchez, Carolina Xipell, Sira Aguiló, Pere Llorens
BACKGROUND AND OBJECTIVES: The aim of this study was to define the following in patients with acute heart failure (AHF) discharged directly from accident and emergency (A&E): rates of reconsultation to A&E and hospitalisation for AHF, and all-cause death at 30 days, rate of combined event at 7 days and the factors associated with these rates. PATIENTS AND METHOD: The study included patients consecutively diagnosed with AHF during 2 months in 27 Spanish A&E departments who were discharged from A&E without hospitalisation...
July 20, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28713260/automated-detection-of-epileptic-biomarkers-in-resting-state-interictal-meg-data
#9
Miguel C Soriano, Guiomar Niso, Jillian Clements, Silvia Ortín, Sira Carrasco, María Gudín, Claudio R Mirasso, Ernesto Pereda
Certain differences between brain networks of healthy and epilectic subjects have been reported even during the interictal activity, in which no epileptic seizures occur. Here, magnetoencephalography (MEG) data recorded in the resting state is used to discriminate between healthy subjects and patients with either idiopathic generalized epilepsy or frontal focal epilepsy. Signal features extracted from interictal periods without any epileptiform activity are used to train a machine learning algorithm to draw a diagnosis...
2017: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/28694632/late-onset-familial-amyloidotic-polyneuropathy-with-bence-jones-proteinuria-and-cardiomyopathy
#10
Sira Carrasco García de León, Amalia Hernández González, Carmen Orellana Alonso, Laura Burriel Lobo
Familial amyloidotic polyneuropathy is a genetically determined disease characterized by deposition of an anomalous transthyretin. A high index of suspicion is needed for this multisymptomatic and lethal disease to be diagnosed. The patient was a 70-year-old male examined due to hypesthesia in the hands and feet, plus difficulty walking. A neurophysiological study delivered the diagnosis of axonal sensorimotor polyneuropathy. He later developed cardiac symptoms and diarrhea. Urine laboratory analyses revealed a monoclonal spike of light chains (kappa)...
July 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28683709/-linagliptin-induced-liver-toxicity
#11
Emma Bartolomé-García, Sira Sanz-Márquez, Montserrat Pérez-Encinas
No abstract text is available yet for this article.
July 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28674377/sirtuin-a-regulates-secondary-metabolite-production-by-aspergillus-nidulans
#12
Eriko Itoh, Ryosuke Shigemoto, Ken-Ichi Oinuma, Motoyuki Shimizu, Shunsuke Masuo, Naoki Takaya
Late-stage cultures of filamentous fungi under nutrient starvation produce valuable secondary metabolites such as pharmaceuticals and pigments, as well as deleterious mycotoxins, all of which have remarkable structural diversity and wide-spectrum bioactivity. The fungal mechanisms regulating the synthesis of many of these compounds are not fully understood, but sirtuin A (SirA) is a key factor that initiates production of the secondary metabolites, sterigmatocystin and penicillin G, by Aspergillus nidulans...
July 1, 2017: Journal of General and Applied Microbiology
https://www.readbyqxmd.com/read/28624828/unique-imaging-features-enabling-the-prenatal-diagnosis-of-developmental-venous-anomalies-a-persistent-echogenic-brain-lesion-drained-by-a-collecting-vein-in-contrast-with-normal-brain-parenchyma-on-mri
#13
Karina Krajden Haratz, Alon Peled, Boris Weizman, Liat Gindes, Mordechai Tamarkin, Dorit Lev, Dvora Kidron, Liat Ben-Sira, Gustavo Malinger, Tally Lerman-Sagie, Zvi Leibovitz
OBJECTIVE: To describe the prenatal imaging features enabling diagnosis of developmental venous anomalies (DVA). METHODS: Four fetuses with unexplained persistent echogenic parenchymal brain lesions were studied. The evaluation included dedicated neurosonography, fetal MRI, serology for intrauterine infection, screening for coagulation abnormalities, and chromosomal microarray. Postnatal neurodevelopmental follow-up or autopsy results were assessed. RESULTS: DVA presented as very slowly growing echogenic brain lesions without cystic components, calcifications, or structural changes on otherwise normal neurosonographic scans performed at 2- to 3-week intervals...
June 17, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28591659/decreased-levels-of-matrix-metalloproteinase-2-in-root-canal-exudates-during-root-canal-treatment
#14
Kassara Pattamapun, Sira Handagoon, Thanapat Sastraruji, James L Gutmann, Prasit Pavasant, Suttichai Krisanaprakornkit
OBJECTIVE: To determine the matrix metalloproteinase-2 (MMP-2) levels in root-canal exudates from teeth undergoing root-canal treatment. MATERIAL AND METHODS: The root-canal exudates from six teeth with normal pulp and periradicular tissues that required intentional root canal treatment for prosthodontic reasons and from twelve teeth with pulp necrosis and asymptomatic apical periodontitis (AAP) were sampled with paper points for bacterial culture and aspirated for the detection of proMMP-2 and active MMP-2 by gelatin zymography and the quantification of MMP-2 levels by ELISA...
October 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28588613/preoperative-serum-il-12p40-is-a-potential-predictor-of-kasai-portoenterostomy-outcome-in-infants-with-biliary-atresia
#15
Shaimaa Samy Goda, Mohamed Ahmed Khedr, Soha Zaki Elshenawy, Tarek Mohamed Ibrahim, Hanaa Ahmed El-Araby, Mostafa Mohamed Sira
The standard-of-care treatment for biliary atresia (BA) is surgical restoration of bile flow by Kasai portoenterostomy. We aimed to study serum interleukin- (IL-) 12p40, a natural antagonist for the proinflammatory IL-12p70, and its relation to surgical outcomes of BA. The study included 75 infants with neonatal cholestasis: BA group (n = 25), non-BA cholestasis group (n = 30), and neglected BA group (n = 20), in addition to thirty healthy neonates serving as controls. IL-12p40 was measured by ELISA in all individuals and a second assessment was performed 3 months postoperatively in the BA group...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28571760/a-bivalent-dendrimeric-peptide-bearing-a-t-cell-epitope-from-foot-and-mouth-disease-virus-protein-3a-improves-humoral-response-against-classical-swine-fever-virus
#16
José Alejandro Bohórquez, Sira Defaus, Sara Muñoz-González, Marta Perez-Simó, Rosa Rosell, Lorenzo Fraile, Francisco Sobrino, David Andreu, Llilianne Ganges
Three dendrimeric peptides were synthesized in order to evaluate their immunogenicity and their potential protection against classical swine fever virus (CSFV) in domestic pigs. Construct 1, an optimized version of a previously used dendrimer, had four copies of a B-cell epitope derived from CSFV E2 glycoprotein connected to an also CSFV-derived T-cell epitope through maleimide instead of thioether linkages. Construct 2 was similarly built but included only two copies of the B-cell epitope, and in also bivalent construct 3 the CSFV T-cell epitope was replaced by a previously described one from the 3A protein of foot-and-mouth disease virus (FMDV)...
May 30, 2017: Virus Research
https://www.readbyqxmd.com/read/28499216/biobrick-chain-recommendations-for-genetic-circuit-design
#17
Jiaoyun Yang, Song Yu, Bowen Gong, Ning An, Gil Alterovitz
Synthetic biology databases have collected numerous biobricks to accelerate genetic circuit design. However, selecting biobricks is a tough task. Here, we leverage the fact that these manually designed circuits can provide underlying knowledge to support biobrick selection. We propose to design a recommendation system based on the analysis of available genetic circuits, which can narrow down the biobrick selection range and provide candidate biobricks for users to choose. A recommendation strategy based on a Markov model is established to tackle this issue...
July 1, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28393638/vascular-territorial-segmentation-and-volumetric-blood-flow-measurement-using-dynamic-contrast-enhanced-magnetic-resonance-angiography-of-the-brain
#18
Oren Geri, Shelly I Shiran, Jonathan Roth, Moran Artzi, Liat Ben-Sira, Dafna Ben Bashat
This study proposes a method for territorial segmentation and volumetric flow rate (VFR) distribution measurement of cerebral territories based on time-resolved contrast enhanced magnetic-resonance-angiography (MRA). The method uses an iterative region-growing algorithm based on bolus-arrival-time with increased temporal resolution. Eight territories were segmented: (1) right and (2) left internal carotid arteries, including the middle cerebral artery (ICA+MCA), excluding the anterior cerebral arteries (ACA); (3) right and left ACA (R+L-ACA); (4) right and (5) left external carotid arteries (ECA); (6) right and (7) left posterior cerebral arteries (PCA); and (8) vertebrobasilar territory...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28289902/discovery-of-synthesis-and-secretion-of-polyol-esters-of-fatty-acids-by-four-basidiomycetous-yeast-species-in-the-order-sporidiobolales
#19
Luis A Garay, Irnayuli R Sitepu, Tomas Cajka, Oliver Fiehn, Erin Cathcart, Russell W Fry, Atit Kanti, Agustinus Joko Nugroho, Sarah Asih Faulina, Sira Stephanandra, J Bruce German, Kyria L Boundy-Mills
Polyol esters of fatty acids (PEFA) are amphiphilic glycolipids produced by yeast that could play a role as natural, environmentally friendly biosurfactants. We recently reported discovery of a new PEFA-secreting yeast species, Rhodotorula babjevae, a basidiomycetous yeast to display this behavior, in addition to a few other Rhodotorula yeasts reported on the 1960s. Additional yeast species within the taxonomic order Sporidiobolales were screened for secreted glycolipid production. PEFA production equal or above 1 g L(-1) were detected in 19 out of 65 strains of yeast screened, belonging to 6 out of 30 yeast species tested...
March 13, 2017: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28286529/a-synthetic-strategy-for-conjugation-of-paromomycin-to-cell-penetrating-tat-48-60-for-delivery-and-visualization-into-leishmania-parasites
#20
Sira Defaus, Maria Gallo, María A Abengózar, Luis Rivas, David Andreu
A successful approach to deliver paromomycin, a poorly absorbed aminoglycoside antibiotic, to parasite cells is reported, based on selective protection of amino and hydroxyl groups followed by conjugation to a fluorolabeled, PEG-functionalized cell-penetrating Tat(48-60) peptide. The resulting construct is efficiently internalized into Leishmania cells, evidencing the fitness of cell-penetrating peptides as vectors for efficiently transporting low-bioavailability drugs into cells.
2017: International Journal of Peptides
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