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Buranee Kanchanatawan, Sira Sriswasdi, Supaksorn Thika, Sunee Sirivichayakul, André F Carvalho, Michel Geffard, Marta Kubera, Michael Maes
Deficit schizophrenia is characterized by neurocognitive impairments and changes in the patterning of IgA/IgM responses to plasma tryptophan catabolites (TRYCATs). In the current study, supervised pattern recognition methods, including logistic regression analysis (LRA), Support Vector Machine (SVM), and Soft Independent Modeling of Class Analogy (SIMCA), were used to examine whether deficit schizophrenia is a discrete diagnostic class with respect to Consortium To Establish a Registry for Alzheimer's disease (CERAD) and Cambridge Neuropsychological Test Automated Battery (CANTAB) tests and IgA/IgM responses to noxious (NOX) and generally more protective (PRO) TRYCATs...
March 11, 2018: Metabolic Brain Disease
Alejandro López-Hernández, Blanca Vivanco, Alessandro Franchi, Elisabeth Bloemena, Virginia N Cabal, Sira Potes, Cristina Riobello, Cristina García-Inclán, Fernando López, José L Llorente, Mario Hermsen
The sinonasal cavities harbour a variety of rare tumour types. Many carry a poor prognosis while therapeutic options are limited. Histopathological classification can be difficult, especially for poorly differentiated tumours such as olfactory neuroblastoma (ONB), sinonasal neuroendocrine carcinoma (SNEC) and sinonasal undifferentiated carcinoma (SNUC). We analysed Affymetrix OncoScan genome-wide copy number profiles of these three tumour types, both as originally diagnosed and as regrouped by their cytokeratin (Ck) and neuroendocrine (Ne) expression pattern, aiming to find a relation between phenotype and genotype...
March 5, 2018: Scientific Reports
Titikan Somboon, Sira Sansuk
An alternative approach using visible chemical waves for ethanol determination is presented. The method is based on the dynamic change of chemical waves in the Belousov-Zhabotinsky (BZ) reaction by perturbation with ethanol. The observablepropagating waves, generatedina Petri dish, can be recorded by using a smartphone camera. The propagating distances are measured from photographic images and then plotted as a function of time to attain the wave velocity. It is found that wave velocities are inversely proportional to ethanol concentrations...
July 1, 2018: Food Chemistry
K Nithin Prabhu, Shrikrishna Isloor, B Hanchinal Veeresh, Doddamane Rathnamma, R Sharada, Lekshmi J Das, M L Satyanarayana, Nagendra R Hegde, Sira Abdul Rahman
Accurate and early diagnosis of animal rabies is critical for undertaking public health measures. Whereas the direct fluorescent antibody (DFA) technique is the recommended test, the more convenient, direct rapid immunochemistry test (dRIT), as well as the more sensitive, reverse transcription polymerase chain reaction (RT-PCR), have recently been employed for the laboratory diagnosis of rabies. We compared the three methods on brain samples from domestic (dog, cat, cattle, buffalo, horse, pig and goat) and wild (leopard, wolf and jackal) animals from various parts of India...
February 28, 2018: Veterinary Sciences
Haidy Mohammed Zakaria, Tahany Abdel-Hamid Salem, Hanaa Ahmed El-Araby, Rawan Mohammed Salama, Doaa Yousry Elbadry, Ahmad Mohamed Sira, Mohammed Abdul-Hafeez Ali, Menan El-Sayed Salem, Basma Mahmoud Abd-Alaaty, Shaimaa Samy Goda, Sara Mohammed Eltaras, Fatma Omar Khalil, Sahar Shahein Abou-Zeinah, Mostafa Mohamed Sira
Fulminant hepatic failure is a life-threatening disease. Hepatitis A virus (HAV) can cause fulminant hepatic failure and death in about 0.2% of cases. Extensive destruction of infected hepatocytes by immune-mediated lysis is thought to be the cause. We aimed to evaluate the use of steroid therapy in children with fulminant HAV. This study included 33 children with fulminant HAV in two groups. Steroid group; comprised of 18 children who received prednisolone (1 mg/kg/d) or its equivalent dose of methylprednisolone and the non-steroid group; comprised another 15 children who did not receive steroid therapy...
February 3, 2018: Journal of Viral Hepatitis
Dominik Dornfeld, Alexandra H Dudek, Thibaut Vausselin, Sira C Günther, Judd F Hultquist, Sebastian Giese, Daria Khokhlova-Cubberley, Yap C Chew, Nevan J Krogan, Adolfo Garcia-Sastre, Martin Schwemmle, Megan L Shaw
The human interferon (IFN)-induced MxA protein is a key antiviral host restriction factor exhibiting broad antiviral activity against many RNA viruses, including highly pathogenic avian influenza A viruses (IAV) of the H5N1 and H7N7 subtype. To date the mechanism for how MxA exerts its antiviral activity is unclear, however, additional cellular factors are believed to be essential for this activity. To identify MxA cofactors we performed a genome-wide siRNA-based screen in human airway epithelial cells (A549) constitutively expressing MxA using an H5N1 reporter virus...
February 1, 2018: Scientific Reports
Mathilde Varret, Marianne Abifadel, Athina Despina Kalopissis, Sira Fatoumata Maiga, Gilles Lambert, Nabil G Seidah, Catherine Boileau, Michele Chabert
No abstract text is available yet for this article.
August 2017: Atherosclerosis
Cristina Riobello, Blanca Vivanco, Sara Reda, Alejandro López-Hernández, Cristina García-Inclán, Sira Potes-Ares, Virginia N Cabal, Fernando López, José Luis Llorente, Mario A Hermsen
BACKGROUND: Sinonasal cancer carries a poor prognosis, especially in recurrent stages, and it is a disease with very limited treatment options. METHODS: The expression of programmed death ligand-1 (PD-L1) as a marker for immunotherapy was evaluated in 53 sinonasal squamous cell carcinoma (SCC) and 126 intestinal-type adenocarcinoma (ITAC) samples. Results were correlated to clinicopathological characteristics and follow-up data. RESULTS: Membranous PD-L1 staining of tumor cells was observed in 34% (18/53) of the sinonasal SCC samples and in 17% (22/126) of the ITAC samples...
January 22, 2018: Head & Neck
Albert Roger, Maria Basagana, Aina Teniente-Serra, Nathalie Depreux, Yanina Jurgens, Clara Padro, Sira Miquel, Carolina Elduque, Eva M Martinez-Caceres
Nowadays, specific immunotherapy is the only successful disease-modifying therapy for IgE-mediated allergic diseases. In this review we analyse different antigen-specific immunotherapies according to administration route, type of antigens and adjuvants, and we address the special case of food allergy.
January 15, 2018: Current Pharmaceutical Design
Jaume Capellades, Josep Puig, Sira Domenech, Teresa Pujol, Laura Oleaga, Angels Camins, Carles Majós, Rocio Diaz, Christian de Quintana, Pilar Teixidor, Gerard Conesa, Gerard Plans, Josep Gonzalez, Natalia García-Balañà, Jose Maria Velarde, Carmen Balaña
To assess the value of resection in glioblastoma based on pre-surgical tumor characteristics and a subsequent staging system. The lack of a staging system for glioblastoma hinders the analysis of treatment outcome. We classified 292 uniformly treated glioblastoma patients as stage I, II, or III based on tumor size, location, and eloquence and then analyzed the impact of the extent of resection. We classified 62% of patients as stage I, 25.3% as stage II, and 12.7% as stage III. Gross total resection (GTR) was performed mainly in stage I rather than stage II or III patients (79...
December 28, 2017: Journal of Neuro-oncology
Andrée S George, Clayton E Cox, Prerak Desai, Steffen Porwolik, Weiping Chu, Marcos H de Moraes, Michael McClelland, Maria T Brandl, Max Teplitski
The human pathogen Salmonella is remarkably adaptable, and this trait allows these bacteria to thrive in a variety of environments and hosts. The mechanisms with which these pathogens establish within a niche amidst the native microbiota remains poorly understood. Here, we aimed to uncover the mechanisms that enable Salmonella enterica sv. Typhimurium to benefit from the degradation of plant tissue by a soft-rot plant pathogen Pectobacterium carotovorum. The hypothesis that in the soft rot, the liberation of starch (not utilized by P...
December 15, 2017: Applied and Environmental Microbiology
Ignacio Oulego-Erroz, Rafael González-Cortes, Patricia García-Soler, Mónica Balaguer-Gargallo, Manuel Frías-Pérez, Juan Mayordomo-Colunga, Ana Llorente-de-la-Fuente, Paula Santos-Herraiz, Juan José Menéndez-Suso, María Sánchez-Porras, Daniel Palanca-Arias, Carmen Clavero-Rubio, Mª Soledad Holanda-Peña, Luis Renter-Valdovinos, Sira Fernández-De-Miguel, Antonio Rodríguez-Núñez
PURPOSE: To assess whether ultrasound guidance improves central venous catheter placement outcomes compared to the landmark technique in critically ill children. METHODS: A prospective multicentre observational study was carried out in 26 paediatric intensive care units over 6 months. Children 0-18 years old who received a temporary central venous catheter, inserted using either ultrasound or landmark techniques, were eligible. The primary outcome was the first-attempt success rate...
January 2018: Intensive Care Medicine
Satish K Mandlik, Shridhar S Siras, Kiran R Birajdar
The aim of the present research work was to develop, characterize and optimize sertaconazole nitrate (STZN) embedded flexisomes (STZN-FS) to improve the cutaneous anti-fungal activity of STZN. Flexisomes are self-aggregating, flexible, deformable lipidic vesicles possessing an aqueous core. A 32 factorial design was implemented to optimize the effects of the critical material attributes of concentration of phospholipid (X1 ) and edge activator (X2 ) on the critical quality attributes of particle size (Y1 ), entrapment efficiency (Y2 ), and deformability index (Y3 )...
December 4, 2017: Journal of Liposome Research
Liat Ben-Sira, Penina Ponger, Shlomi Constantini
OBJECTIVE: To assess the association between dorsal midline skin discolorations, tethering of the spinal cord, and the role of ultrasound screening of these stigmata, focusing specifically on vascular lesions. STUDY DESIGN: We conducted a prospective observational study of infants <6 months of age with suspicious dorsal midline skin stigmata. All were evaluated by physical examination and ultrasound scan. A subset also had a magnetic resonance imaging examination...
November 2017: Journal of Pediatrics
Ezequiel Palmanovich, Moshe Ayalon, David Ben Sira, Meir Nyska, Iftach Hetsroni
BACKGROUND AND PURPOSE: Elevated heel construction offloads the forefoot after surgery. However, side-to-side height difference alters limb kinetics, whereas leg-length equalizing-sole at non-operated side may have beneficial effects on foot loading. The purpose of this study was to characterize leg-length equalizing sole effect on bilateral plantar pressures when using heel-lift forefoot-offloading shoe. MATERIALS AND METHODS: Twenty men were tested walking. Plantar peak pressures (PP) and pressure-time integrals (PTI) in the forefoot-offloading shoe and in contralateral running shoe were compared between two conditions: one with- and the other without leg-length equalizing sole elevation at the running shoe...
October 24, 2017: Foot
Roee Birnbaum, Liat Ben-Sira, Tally Lerman-Sagie, Gustavo Malinger
OBJECTIVE: To analyze ultrasound and MRI results and developmental outcome in cases of maternal primary CMV infection during pregnancy. METHODS: We retrospectively reviewed the results of fetal neurosonography and brain MRI of CMV infected fetuses (Group 1). Cases of maternal infection in which the fetal status was unknown, and subsequently had a negative CMV postnatal urine analysis, were independently analyzed (Group 2). Imaging results were classified as: positive, negative or inconclusive...
November 8, 2017: Prenatal Diagnosis
Jennifer L Brame, Demah Salem AlGheithy, Enrique Platin, Shannon H Mitchell
Purpose: Dental hygiene educators often provide inconsistent instruction in clinical settings and various attempts to address the lack of consistency have been reported in the literature. The purpose of this pilot study was to determine if the use of a use of a self-instructional, radiographic anatomy (SIRA) module improved DH faculty calibration regarding the identifica-tion of normal intraoral and extraoral radiographic anatomy and whether its effect could be sustained over a period of four months.Methods: A convenience sample consisting of all dental hygiene faculty members involved in clinical instruction (N=23) at the University of North Carolina (UNC) was invited to complete the four parts of this online pilot study: a pre-test, review of the SIRA module, an immediate post-test, and a four-month follow-up post-test...
June 2017: Journal of Dental Hygiene: JDH
Szabina Szujo, Livia Sira, Laszlo Bajnok, Beata Bodis, Ferenc Gyory, Orsolya Nemes, Karoly Rucz, Peter Kenyeres, Zsuzsanna Valkusz, Krisztian Sepp, Erzsebet Schmidt, Zsuszanna Szabo, Sarolta Szekeres, Katalin Zambo, Sandor Barna, Endre V Nagy, Emese Mezosi
Objective: SPECT/CT has numerous advantages over planar and traditional SPECT images. The aim of this study was to evaluate the role of post-radioiodine therapy SPECT/CT of patients with differentiated thyroid cancer (DTC) in early risk classification and in prediction of late prognosis. Patients and methods: 323 consecutive patients were investigated after their first radioiodine treatment (1100-3700 MBq). Both whole body scan and SPECT/CT images of the head, neck, chest and abdomen regions were taken 4-6 days after radioiodine therapy...
October 3, 2017: Oncotarget
Carmen Balaña, Jaume Capellades, Estela Pineda, Anna Estival, Josep Puig, Sira Domenech, Eugenia Verger, Teresa Pujol, Maria Martinez-García, Laura Oleaga, JoseMaria Velarde, Carlos Mesia, Rafael Fuentes, Jordi Marruecos, Sonia Del Barco, Salvador Villà, Cristina Carrato, Oscar Gallego, Miguel Gil-Gil, Jordi Craven-Bartle, Francesc Alameda
We explored predictive factors of pseudoprogression (PsP) and its impact on prognosis in a retrospective series of uniformly treated glioblastoma patients. Patients were classified as having PsP, early progression (eP) or neither (nP). We examined potential associations with clinical, molecular, and basal imaging characteristics and compared overall survival (OS), progression-free survival (PFS), post-progression survival (PPS) as well as the relationship between PFS and PPS in the three groups. Of the 256 patients studied, 56 (21...
December 2017: Cancer Medicine
Maria J Torres, Kim A Kew, Terence E Ryan, Edward Ross Pennington, Chien-Te Lin, Katherine A Buddo, Amy M Fix, Cheryl A Smith, Laura A Gilliam, Sira Karvinen, Dawn A Lowe, Espen E Spangenburg, Tonya N Zeczycki, Saame Raza Shaikh, P Darrell Neufer
Menopause results in a progressive decline in 17β-estradiol (E2) levels, increased adiposity, decreased insulin sensitivity, and a higher risk for type 2 diabetes. Estrogen therapies can help reverse these effects, but the mechanism(s) by which E2 modulates susceptibility to metabolic disease is not well understood. In young C57BL/6N mice, short-term ovariectomy decreased-whereas E2 therapy restored-mitochondrial respiratory function, cellular redox state (GSH/GSSG), and insulin sensitivity in skeletal muscle...
January 9, 2018: Cell Metabolism
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