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https://www.readbyqxmd.com/read/29144251/evaluation-of-dorsal-midline-discolorations-with-physical-examination-and-ultrasound
#1
Liat Ben-Sira, Penina Ponger, Shlomi Constantini
OBJECTIVE: To assess the association between dorsal midline skin discolorations, tethering of the spinal cord, and the role of ultrasound screening of these stigmata, focusing specifically on vascular lesions. STUDY DESIGN: We conducted a prospective observational study of infants <6 months of age with suspicious dorsal midline skin stigmata. All were evaluated by physical examination and ultrasound scan. A subset also had a magnetic resonance imaging examination...
November 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29126041/the-effect-of-eliminating-leg-length-difference-on-plantar-foot-pressure-distribution-in-patients-wearing-forefoot-offloading-shoe
#2
Ezequiel Palmanovich, Moshe Ayalon, David Ben Sira, Meir Nyska, Iftach Hetsroni
BACKGROUND AND PURPOSE: Elevated heel construction offloads the forefoot after surgery. However, side-to-side height difference alters limb kinetics, whereas leg-length equalizing-sole at non-operated side may have beneficial effects on foot loading. The purpose of this study was to characterize leg-length equalizing sole effect on bilateral plantar pressures when using heel-lift forefoot-offloading shoe. MATERIALS AND METHODS: Twenty men were tested walking. Plantar peak pressures (PP) and pressure-time integrals (PTI) in the forefoot-offloading shoe and in contralateral running shoe were compared between two conditions: one with- and the other without leg-length equalizing sole elevation at the running shoe...
October 24, 2017: Foot
https://www.readbyqxmd.com/read/29119569/the-utility-of-fetal-neurosonography-and-brain-mri-in-cases-of-cytomegalovirus-infection-during-pregnancy-a-retrospective-analysis-with-outcome-correlation
#3
Roee Birnbaum, Liat Ben-Sira, Tally Lerman-Sagie, Gustavo Malinger
OBJECTIVE: To analyze ultrasound and MRI results and developmental outcome in cases of maternal primary CMV infection during pregnancy. METHODS: We retrospectively reviewed the results of fetal neurosonography and brain MRI of CMV infected fetuses (Group 1). Cases of maternal infection in which the fetal status was unknown, and subsequently had a negative CMV postnatal urine analysis, were independently analyzed (Group 2). Imaging results were classified as: positive, negative or inconclusive...
November 8, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29118066/use-of-a-self-instructional-radiographic-anatomy-module-for-dental-hygiene-faculty-calibration
#4
Jennifer L Brame, Demah Salem AlGheithy, Enrique Platin, Shannon H Mitchell
Purpose: Dental hygiene educators often provide inconsistent instruction in clinical settings and various attempts to address the lack of consistency have been reported in the literature. The purpose of this pilot study was to determine if the use of a use of a self-instructional, radiographic anatomy (SIRA) module improved DH faculty calibration regarding the identifica-tion of normal intraoral and extraoral radiographic anatomy and whether its effect could be sustained over a period of four months.Methods: A convenience sample consisting of all dental hygiene faculty members involved in clinical instruction (N=23) at the University of North Carolina (UNC) was invited to complete the four parts of this online pilot study: a pre-test, review of the SIRA module, an immediate post-test, and a four-month follow-up post-test...
June 2017: Journal of Dental Hygiene: JDH
https://www.readbyqxmd.com/read/29108364/the-impact-of-post-radioiodine-therapy-spect-ct-on-early-risk-stratification-in-differentiated-thyroid-cancer-a-bi-institutional-study
#5
Szabina Szujo, Livia Sira, Laszlo Bajnok, Beata Bodis, Ferenc Gyory, Orsolya Nemes, Karoly Rucz, Peter Kenyeres, Zsuzsanna Valkusz, Krisztian Sepp, Erzsebet Schmidt, Zsuszanna Szabo, Sarolta Szekeres, Katalin Zambo, Sandor Barna, Endre V Nagy, Emese Mezosi
Objective: SPECT/CT has numerous advantages over planar and traditional SPECT images. The aim of this study was to evaluate the role of post-radioiodine therapy SPECT/CT of patients with differentiated thyroid cancer (DTC) in early risk classification and in prediction of late prognosis. Patients and methods: 323 consecutive patients were investigated after their first radioiodine treatment (1100-3700 MBq). Both whole body scan and SPECT/CT images of the head, neck, chest and abdomen regions were taken 4-6 days after radioiodine therapy...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29105360/pseudoprogression-as-an-adverse-event-of-glioblastoma-therapy
#6
Carmen Balaña, Jaume Capellades, Estela Pineda, Anna Estival, Josep Puig, Sira Domenech, Eugenia Verger, Teresa Pujol, Maria Martinez-García, Laura Oleaga, JoseMaria Velarde, Carlos Mesia, Rafael Fuentes, Jordi Marruecos, Sonia Del Barco, Salvador Villà, Cristina Carrato, Oscar Gallego, Miguel Gil-Gil, Jordi Craven-Bartle, Francesc Alameda
We explored predictive factors of pseudoprogression (PsP) and its impact on prognosis in a retrospective series of uniformly treated glioblastoma patients. Patients were classified as having PsP, early progression (eP) or neither (nP). We examined potential associations with clinical, molecular, and basal imaging characteristics and compared overall survival (OS), progression-free survival (PFS), post-progression survival (PPS) as well as the relationship between PFS and PPS in the three groups. Of the 256 patients studied, 56 (21...
November 3, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29103922/17%C3%AE-estradiol-directly-lowers-mitochondrial-membrane-microviscosity-and-improves-bioenergetic-function-in-skeletal-muscle
#7
Maria J Torres, Kim A Kew, Terence E Ryan, Edward Ross Pennington, Chien-Te Lin, Katherine A Buddo, Amy M Fix, Cheryl A Smith, Laura A Gilliam, Sira Karvinen, Dawn A Lowe, Espen E Spangenburg, Tonya N Zeczycki, Saame Raza Shaikh, P Darrell Neufer
Menopause results in a progressive decline in 17β-estradiol (E2) levels, increased adiposity, decreased insulin sensitivity, and a higher risk for type 2 diabetes. Estrogen therapies can help reverse these effects, but the mechanism(s) by which E2 modulates susceptibility to metabolic disease is not well understood. In young C57BL/6N mice, short-term ovariectomy decreased-whereas E2 therapy restored-mitochondrial respiratory function, cellular redox state (GSH/GSSG), and insulin sensitivity in skeletal muscle...
November 1, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/29081845/the-effects-of-aerobic-and-anaerobic-exercises-on-circulating-soluble-klotho-and-igf-i-in-young-and-elderly-adults-and-in-cad-patients
#8
REVIEW
Moran S Saghiv, D Ben Sira, E Goldhammer, M Sagiv
Different studies support the notion that chronic aerobic exercises training can influence the circulating levels of soluble-Klotho (s-Klotho) and insulin-like growth factor 1 (IGF-I). The effects of s-Klotho include improving the quality of life, alleviating the negative impact of age on the body's work capacity, and possibly increasing longevity. This review provides an overview of the latest findings in this field of research in humans. The different modes of dynamic exercise and their impact on circulating levels of s-Klotho and IGF-I in young adult athletes, untrained young adults, trained healthy older adults, untrained healthy older adults, and coronary artery disease (CAD) patients are reviewed and discussed...
January 2017: J Circ Biomark
https://www.readbyqxmd.com/read/29079803/generalist-species-drive-microbial-dispersion-and-evolution
#9
Sira Sriswasdi, Ching-Chia Yang, Wataru Iwasaki
Microbes form fundamental bases of every Earth ecosystem. As their key survival strategies, some microbes adapt to broad ranges of environments, while others specialize to certain habitats. While ecological roles and properties of such "generalists" and "specialists" had been examined in individual ecosystems, general principles that govern their distribution patterns and evolutionary processes have not been characterized. Here, we thoroughly identified microbial generalists and specialists across 61 environments via meta-analysis of community sequencing data sets and reconstructed their evolutionary histories across diverse microbial groups...
October 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/29064908/the-southampton-consensus-guidelines-for-laparoscopic-liver-surgery-from-indication-to-implementation
#10
Mohammad Abu Hilal, Luca Aldrighetti, Ibrahim Dagher, Bjorn Edwin, Roberto Ivan Troisi, Ruslan Alikhanov, Somaiah Aroori, Giulio Belli, Marc Besselink, Javier Briceno, Brice Gayet, Mathieu D'Hondt, Mickael Lesurtel, Krishna Menon, Peter Lodge, Fernando Rotellar, Julio Santoyo, Olivier Scatton, Olivier Soubrane, Robert Sutcliffe, Ronald Van Dam, Steve White, Mark Christopher Halls, Federica Cipriani, Marcel Van der Poel, Ruben Ciria, Leonid Barkhatov, Yrene Gomez-Luque, Sira Ocana-Garcia, Andrew Cook, Joseph Buell, Pierre-Alain Clavien, Christos Dervenis, Giuseppe Fusai, David Geller, Hauke Lang, John Primrose, Mark Taylor, Thomas Van Gulik, Go Wakabayashi, Horacio Asbun, Daniel Cherqui
OBJECTIVE: The European Guidelines Meeting on Laparoscopic Liver Surgery was held in Southampton on February 10 and 11, 2017 with the aim of presenting and validating clinical practice guidelines for laparoscopic liver surgery. BACKGROUND: The exponential growth of laparoscopic liver surgery in recent years mandates the development of clinical practice guidelines to direct the speciality's continued safe progression and dissemination. METHODS: A unique approach to the development of clinical guidelines was adopted...
October 23, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29063803/evaluation-of-chronic-stress-indicators-in-geriatric-and-oncologic-caregivers-a-cross-sectional-study
#11
Sira Aguiló, Esther García, Adriana Arza, Jorge M Garzón-Rey, Jordi Aguiló
Caregiving induces chronic stress with physical and psychological impact on informal caregivers health. Therefore, subjective and objective indicators are needed for the early diagnosis of pathologic stress to prevent the risk of developing stress-related diseases in caregivers. Our aim was to assess the self-perceived stress, that is, how and how much the stressor affects the individual, through endocrine, metabolic, and immunologic biomarkers levels in geriatric and oncologic informal caregivers. Informal caregivers and non-caregivers were invited to participate in a cross-sectional study at the Clinic Hospital of Barcelona...
October 24, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29027707/a-trichosporonales-genome-tree-based-on-27-haploid-and-three-evolutionarily-conserved-natural-hybrid-genomes
#12
Masako Takashima, Sira Sriswasdi, Ri-Ichiroh Manabe, Moriya Ohkuma, Takashi Sugita, Wataru Iwasaki
To construct a backbone tree consisting of basidiomycetous yeasts, draft genome sequences from 25 species of Trichosporonales (Tremellomycetes, Basidiomycota) were generated. In addition to the hybrid genomes of Trichosporon coremiiforme and T. ovoides that we described previously, we identified an interspecies hybrid genome in Cutaneotrichosporon mucoides (formerly T. mucoides). This hybrid genome had a gene retention rate of approximately 55%, and its closest haploid relative was C. dermatis. After constructing the C...
October 13, 2017: Yeast
https://www.readbyqxmd.com/read/28994409/introducing-site-specific-cysteines-into-nanobodies-for-mercury-labelling-allows-de-novo-phasing-of-their-crystal-structures
#13
Simon Boje Hansen, Nick Stub Laursen, Gregers Rom Andersen, Kasper R Andersen
The generation of high-quality protein crystals and the loss of phase information during an X-ray crystallography diffraction experiment represent the major bottlenecks in the determination of novel protein structures. A generic method for introducing Hg atoms into any crystal independent of the presence of free cysteines in the target protein could considerably facilitate the process of obtaining unbiased experimental phases. Nanobodies (single-domain antibodies) have recently been shown to promote the crystallization and structure determination of flexible proteins and complexes...
October 1, 2017: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/28984541/isolated-optic-nerve-gliomas-a-multicenter-historical-cohort-study
#14
Ben Shofty, Liat Ben-Sira, Anat Kesler, George Jallo, Mari L Groves, Rajiv R Iyer, Alvaro Lassaletta, Uri Tabori, Eric Bouffet, Ulrich-Wilhelm Thomale, Pablo Hernáiz Driever, Shlomi Constantini
OBJECTIVE Isolated optic nerve gliomas (IONGs) constitute a rare subgroup of optic pathway gliomas (OPGs). Due to the rarity of this condition and the difficulty in differentiating IONGs from other types of OPGs in most clinical series, little is known about these tumors. Currently, due to lack of evidence, they are managed the same as any other OPG. METHODS The authors conducted a multicenter retrospective cohort study aimed at determining the natural history of IONGs. Included were patients with clear-cut glioma of the optic nerve without posterior (chiasmatic/hypothalamic) involvement...
October 6, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28963820/genomic-profiling-of-intestinal-type-sinonasal-adenocarcinoma-reveals-subgroups-of-patients-with-distinct-clinical-outcomes
#15
Alejandro López-Hernández, Jhudit Pérez-Escuredo, Blanca Vivanco, Cristina García-Inclán, Sira Potes-Ares, Virginia N Cabal, Cristina Riobello, María Costales, Fernando López, José Luis Llorente, Mario A Hermsen
BACKGROUND: Patients with intestinal-type sinonasal adenocarcinoma (ITAC) have an unfavorable prognosis and new therapeutic approaches are needed to improve clinical management. METHODS: Genetic analysis of 96 ITACs was performed by microarray comparative genomic hybridization and immunohistochemistry and correlated to previously obtained mutation, methylation, and protein expression data, and with pathological characteristics and clinical outcome. RESULTS: Seven copy number alterations (CNAs) were significantly associated with unfavorable clinical outcome: gains at 1q22-23, 3q28-29, 6p22, and 13q31-33, and losses at 4p15-16, 4q32-35, and 10q24...
September 30, 2017: Head & Neck
https://www.readbyqxmd.com/read/28899552/the-use-of-dissolvable-layered-double-hydroxide-components-in-an-in-situ-solid-phase-extraction-for-chromatographic-determination-of-tetracyclines-in-water-and-milk-samples
#16
Nattaphorn Phiroonsoontorn, Sira Sansuk, Yanawath Santaladchaiyakit, Supalax Srijaranai
This research presents a simple and green in situ solid phase extraction (is-SPE) combined with high-performance liquid chromatography (HPLC) for the simultaneous analysis of tetracyclines (TCs) including tetracycline, oxytetracycline, and chlortetracycline. In is-SPE, TCs were efficiently extracted through the precipitation formation of dissolvable layered double hydroxides (LDHs) by mixing the LDH components such as magnesium and aluminum ions (both in metal chloride salts) thoroughly in an alkaline sample solution...
October 13, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28898865/automatic-measurement-of-fetal-brain-development-from-magnetic-resonance-imaging-new-reference-data
#17
Daphna Link, Michael B Braginsky, Leo Joskowicz, Liat Ben Sira, Shaul Harel, Ariel Many, Ricardo Tarrasch, Gustavo Malinger, Moran Artzi, Cassandra Kapoor, Elka Miller, Dafna Ben Bashat
BACKGROUND: Accurate fetal brain volume estimation is of paramount importance in evaluating fetal development. The aim of this study was to develop an automatic method for fetal brain segmentation from magnetic resonance imaging (MRI) data, and to create for the first time a normal volumetric growth chart based on a large cohort. SUBJECTS AND METHODS: A semi-automatic segmentation method based on Seeded Region Growing algorithm was developed and applied to MRI data of 199 typically developed fetuses between 18 and 37 weeks' gestation...
September 13, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28884514/estrogenic-regulation-of-skeletal-muscle-proteome-a-study-of-premenopausal-women-and-postmenopausal-mz-cotwins-discordant-for-hormonal-therapy
#18
Eija K Laakkonen, Rabah Soliymani, Sira Karvinen, Jaakko Kaprio, Urho M Kujala, Marc Baumann, Sarianna Sipilä, Vuokko Kovanen, Maciej Lalowski
Female middle age is characterized by a decline in skeletal muscle mass and performance, predisposing women to sarcopenia, functional limitations, and metabolic dysfunction as they age. Menopausal loss of ovarian function leading to low circulating level of 17β-estradiol has been suggested as a contributing factor to aging-related muscle deterioration. However, the underlying molecular mechanisms remain largely unknown and thus far androgens have been considered as a major anabolic hormone for skeletal muscle...
December 2017: Aging Cell
https://www.readbyqxmd.com/read/28878664/a-novel-prkar1a-mutation-identified-in-a-patient-with-isolated-primary-pigmented-nodular-adrenocortical-disease
#19
Sira Korpaisarn, Objoon Trachoo, Bhakbhoom Panthan, Rangsima Aroonroch, Ronnarat Suvikapakornkul, Chutintorn Sriphrapradang
Primary pigmented nodular adrenocortical disease (PPNAD) is a rare cause of Cushing syndrome, especially the isolated form without Carney complex, associated with germline mutations in PRKAR1A, the protein kinase A regulatory subunit type 1 alpha gene. We report a 31-year-old female who presented with secondary amenorrhea, cushingoid appearance, and hypertension without Carney complex. Biochemical laboratory examinations confirmed the ACTH-independent adrenal Cushing syndrome with negative Liddle test. A small right adrenal adenoma of 0...
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28815508/multipart-dna-assembly-using-site-specific-recombinases-from-the-large-serine-integrase-family
#20
Femi J Olorunniji, Christine Merrick, Susan J Rosser, Margaret C M Smith, W Marshall Stark, Sean D Colloms
Assembling multiple DNA fragments into functional plasmids is an important and often rate-limiting step in engineering new functions in living systems. Bacteriophage integrases are enzymes that carry out efficient recombination reactions between short, defined DNA sequences known as att sites. These DNA splicing reactions can be used to assemble large numbers of DNA fragments into a functional circular plasmid in a method termed serine integrase recombinational assembly (SIRA). The resulting DNA assemblies can easily be modified by further recombination reactions catalyzed by the same integrase in the presence of its recombination directionality factor (RDF)...
2017: Methods in Molecular Biology
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