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https://www.readbyqxmd.com/read/29763451/episodic-memory-and-delayed-recall-are-significantly-more-impaired-in-younger-patients-with-deficit-schizophrenia-than-in-elderly-patients-with-amnestic-mild-cognitive-impairment
#1
Buranee Kanchanatawan, Sookjaroen Tangwongchai, Thitiporn Supasitthumrong, Sira Sriswasdi, Michael Maes
BACKGROUND: Both amnestic mild cognitive impairment (aMCI) and schizophrenia, in particular deficit schizophrenia, are accompanied by cognitive impairments. The aim of the present study was to examine the cognitive differences between aMCI and (non)deficit schizophrenia. METHODS: Towards this end we recruited 60 participants with aMCI, 40 with deficit and 40 with nondeficit schizophrenia and 103 normal volunteers. Cognitive measures were assessed with the Consortium to Establish a Registry for Alzheimer's disease (CERAD) using the Verbal Fluency Test (VFT), Boston Naming Test (BNT), Mini-Mental State Examination (MMSE), Word list memory (WLM), Word list recall (WLRecall) and Word list recognition (WLRecognition)...
2018: PloS One
https://www.readbyqxmd.com/read/29760472/author-correction-smarca2-regulated-host-cell-factors-are-required-for-mxa-restriction-of-influenza-a-viruses
#2
Dominik Dornfeld, Alexandra H Dudek, Thibaut Vausselin, Sira C Günther, Judd F Hultquist, Sebastian Giese, Daria Khokhlova-Cubberley, Yap C Chew, Lars Pache, Nevan J Krogan, Adolfo Garcia-Sastre, Martin Schwemmle, Megan L Shaw
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
May 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29730101/use-of-eos%C3%A2-low-dose-biplanar-x-ray-for-shunt-series-in-children-with-hydrocephalus-a-preliminary-study
#3
Liat Ben-Sira, Shelly I Shiran, Li-Tal Pratt, Ronit Precel, Ovadia, Shlomi Constantini, Jonathan Roth
INTRODUCTION: Shunt series (SS) are a common diagnostic tool used to verify shunt integrity. SS include X-ray films of the skull, chest, and abdomen, and are often performed either when a shunted patient presents with suspected shunt malfunction, or as a screening test to identify shunt disconnections or dislodgment. EOS low-dose biplanar X-rays are associated with significantly reduced radiation doses compared to ordinary X-rays, and are used for various indications. This is the first publication on the use of EOS as a SS technique...
May 3, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29707058/t1-weighted-mr-imaging-of-bone-marrow-pattern-in-children-with-adolescent-idiopathic-scoliosis-a-preliminary-study
#4
S I Shiran, L Shabtai, L Ben-Sira, D Ovadia, S Wientroub
Purpose: Distinct normal physiological patterns of fat conversion in vertebrae were described both for children and adults. Our aim was to evaluate the T1-weighted bone marrow pattern of the vertebral bodies in various sites along the scoliotic spine of children with adolescent idiopathic scoliosis (AIS). Methods: We retrospectively evaluated spine MRI studies of children with AIS. Scoliosis radiographs were assessed for type of curvature according to the Lenke classification...
April 1, 2018: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29696024/cutaneous-vasculitis-and-recurrent-infection-caused-by-deficiency-in-complement-factor-i
#5
Sira Nanthapisal, Despina Eleftheriou, Kimberly Gilmour, Valentina Leone, Radhika Ramnath, Ebun Omoyinmi, Ying Hong, Nigel Klein, Paul A Brogan
Cutaneous leukocytoclastic vasculitis arises from immune complex deposition and dysregulated complement activation in small blood vessels. There are many causes, including dysregulated host response to infection, drug reactions, and various autoimmune conditions. It is increasingly recognised that some monogenic autoinflammatory diseases cause vasculitis, although genetic causes of vasculitis are extremely rare. We describe a child of consanguineous parents who presented with chronic cutaneous leukocytoclastic vasculitis, recurrent upper respiratory tract infection, and hypocomplementaemia...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29671799/from-the-paper-to-the-tablet-on-the-design-of-an-ar-based-tool-for-the-inspection-of-pre-fab-buildings-preliminary-results-of-the-sirae-project
#6
Cristina Portalés, Sergio Casas, Jesús Gimeno, Marcos Fernández, Montse Poza
Energy-efficient Buildings (EeB) are demanded in today’s constructions, fulfilling the requirements for green cities. Pre-fab buildings, which are modularly fully-built in factories, are a good example of this. Although this kind of building is quite new, the in situ inspection is documented using traditional tools, mainly based on paper annotations. Thus, the inspection process is not taking advantage of new technologies. In this paper, we present the preliminary results of the SIRAE project that aims to provide an Augmented Reality (AR) tool that can seamlessly aid in the regular processes of pre-fab building inspections to detect and eliminate the possible existing quality and energy efficiency deviations...
April 19, 2018: Sensors
https://www.readbyqxmd.com/read/29663106/prevalence-of-thyroid-diseases-in-familial-adenomatous-polyposis-a-systematic-review-and-meta-analysis
#7
Jirat Chenbhanich, Amporn Atsawarungruangkit, Sira Korpaisarn, Tanit Phupitakphol, Soravis Osataphan, Prasit Phowthongkum
Thyroid cancer (TC) is a known extra-intestinal manifestation and contributes to the mortality and morbidity in patients with familial adenomatous polyposis (FAP). Its exact prevalence is not well established and recent studies have shown an increasing number of TC in this patient population. The prevalence of benign thyroid masses and endocrinologic thyroid disorders are also poorly described. We conducted a systematic review and meta-analysis by using a random-effects model to characterize TC and estimated the prevalence of thyroid diseases in FAP patients...
April 16, 2018: Familial Cancer
https://www.readbyqxmd.com/read/29621359/applying-chlorogenic-acid-in-an-alginate-scaffold-of-chondrocytes-can-improve-the-repair-of-damaged-articular-cartilage
#8
Xin Cheng, Ke Li, Shengsong Xu, Peizhi Li, Yu Yan, Guang Wang, Zachary Berman, Rui Guo, Jianxin Liang, Sira Traore, Xuesong Yang
Damaged cartilage has very low regenerative potential which has led to the search for novel tissue-engineering approaches to help treat cartilage defects. While various approaches have been reported, there is no perfect treatment currently. In this study we evaluated the effects of a plant extract, chlorogenic acid (CGA), as part of chondrocyte transplantation on a model of knee joint injury in chicks. First, primary cultured chondrocytes used to evaluate the effects of CGA on chondrogenesis. Then using an articular cartilage injury model of chick knee we assessed the functional recovery after transplantation of the complexes containing chondrocytes and CGA in an alginate scaffold...
2018: PloS One
https://www.readbyqxmd.com/read/29617684/characteristics-of-mild-cognitive-impairment-using-the-thai-version-of-the-consortium-to-establish-a-registry-for-alzheimer-s-disease-tests-a-multivariate-and-machine-learning-study
#9
Chavit Tunvirachaisakul, Thitiporn Supasitthumrong, Sookjareon Tangwongchai, Solaphat Hemrunroj, Phenphichcha Chuchuen, Itthipol Tawankanjanachot, Yuthachai Likitchareon, Kamman Phanthumchinda, Sira Sriswasdi, Michael Maes
BACKGROUND: The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) developed a neuropsychological battery (CERAD-NP) to screen patients with Alzheimer's dementia. Mild cognitive impairment (MCI) has received attention as a pre-dementia stage. OBJECTIVES: To delineate the CERAD-NP features of MCI and their clinical utility to externally validate MCI diagnosis. METHODS: The study included 60 patients with MCI, diagnosed using the Clinical Dementia Rating, and 63 normal controls...
April 4, 2018: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/29617298/lectin-binding-specificity-of-the-fertilization-relevant-protein-pdc-109-by-means-of-surface-plasmon-resonance-and-carbohydrate-recognition-domain-excision-mass-spectrometry
#10
Sira Defaus, Manuel Avilés, David Andreu, Ricardo Gutiérrez-Gallego
Seminal plasma proteins are relevant for sperm functionality and some appear responsible for establishing sperm interactions with the various environments along the female genital tract towards the oocyte. In recent years, research has focused on characterizing the role of these proteins in the context of reproductive biology, fertility diagnostics and treatment of related problems. Herein, we focus on the main protein of bovine seminal plasma, PDC-109 (BSP-A1/-A2), which by virtue of its lectin properties is involved in fertilization...
April 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29594372/short-term-outcomes-of-heart-failure-patients-with-reduced-and-preserved-ejection-fraction-after-acute-decompensation-according-to-the-final-destination-after-emergency-department-care
#11
Òscar Miró, V Íctor Gil, Francisco Javier Martín-Sánchez, Javier Jacob, Pablo Herrero, Aitor Alquézar, Lluís Llauger, Sira Aguiló, Gemma Martínez, José Ríos, Alberto Domínguez-Rodríguez, Veli-Pekka Harjola, Christian Müller, John Parissis, W Frank Peacock, Pere Llorens
AIMS: To compare short-term outcomes after an episode of acute heart failure (AHF) in patients with reduced and preserved ejection fractions (HFrEF, < 40%; and HFpEF, > 49%; respectively) according to their destinations after emergency department (ED) care. METHODS AND RESULTS: This secondary analysis of the EAHFE Registry (consecutive AHF patients diagnosed in 41 Spanish EDs) investigated 30-day all-cause mortality, in-hospital all-cause mortality, prolonged hospitalisation (> 7 days), and 30-day post-discharge ED revisit due to AHF, all-cause death, and combined endpoint (ED revisit/death) in 5829 patients with echocardiographically documented HFrEF and HfpEF (HFrEF/HFpEF: 1,442/4,387)...
March 28, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29573781/predictive-value-of-egfr-pi3k-pakt-mtor-ps6-pathway-in-sinonasal-squamous-cell-carcinomas
#12
María Gabriela Muñoz-Cordero, Fernando López, Cristina García-Inclán, Alejandro López-Hernández, Sira Potes-Ares, Laura Fernández-Vañes, José Luis Llorente, Mario Hermsen
BACKGROUND AND OBJECTIVES: We have previously indicated that EGFR has a role in carcinogenesis in a subgroup of sinonasal squamous cell carcinomas (SNSCC). In addition, EGFR activates 2 of the most important intracellular signalling pathways: PI3K/pAKT/mTOR/pS6 and MAP pathway kinases. The objective of this study was to evaluate the involvement of the EGFR/PI3K/pAKT/mTOR/pS6 pathway and its relationship with clinical-pathological parameters and follow-up of sinonasal squamous cell carcinoma...
March 21, 2018: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/29527624/deficit-schizophrenia-is-a-discrete-diagnostic-category-defined-by-neuro-immune-and-neurocognitive-features-results-of-supervised-machine-learning
#13
Buranee Kanchanatawan, Sira Sriswasdi, Supaksorn Thika, Sunee Sirivichayakul, André F Carvalho, Michel Geffard, Marta Kubera, Michael Maes
Deficit schizophrenia is characterized by neurocognitive impairments and changes in the patterning of IgA/IgM responses to plasma tryptophan catabolites (TRYCATs). In the current study, supervised pattern recognition methods, including logistic regression analysis (LRA), Support Vector Machine (SVM), and Soft Independent Modeling of Class Analogy (SIMCA), were used to examine whether deficit schizophrenia is a discrete diagnostic class with respect to Consortium To Establish a Registry for Alzheimer's disease (CERAD) and Cambridge Neuropsychological Test Automated Battery (CANTAB) tests and IgA/IgM responses to noxious (NOX) and generally more protective (PRO) TRYCATs...
March 11, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29507386/genetic-profiling-of-poorly-differentiated-sinonasal-tumours
#14
Alejandro López-Hernández, Blanca Vivanco, Alessandro Franchi, Elisabeth Bloemena, Virginia N Cabal, Sira Potes, Cristina Riobello, Cristina García-Inclán, Fernando López, José L Llorente, Mario Hermsen
The sinonasal cavities harbour a variety of rare tumour types. Many carry a poor prognosis while therapeutic options are limited. Histopathological classification can be difficult, especially for poorly differentiated tumours such as olfactory neuroblastoma (ONB), sinonasal neuroendocrine carcinoma (SNEC) and sinonasal undifferentiated carcinoma (SNUC). We analysed Affymetrix OncoScan genome-wide copy number profiles of these three tumour types, both as originally diagnosed and as regrouped by their cytokeratin (Ck) and neuroendocrine (Ne) expression pattern, aiming to find a relation between phenotype and genotype...
March 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29502836/an-instrument-free-method-based-on-visible-chemical-waves-for-quantifying-the-ethanol-content-in-alcoholic-beverages
#15
Titikan Somboon, Sira Sansuk
An alternative approach using visible chemical waves for ethanol determination is presented. The method is based on the dynamic change of chemical waves in the Belousov-Zhabotinsky (BZ) reaction by perturbation with ethanol. The observablepropagating waves, generatedina Petri dish, can be recorded by using a smartphone camera. The propagating distances are measured from photographic images and then plotted as a function of time to attain the wave velocity. It is found that wave velocities are inversely proportional to ethanol concentrations...
July 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29495649/application-and-comparative-evaluation-of-fluorescent-antibody-immunohistochemistry-and-reverse-transcription-polymerase-chain-reaction-tests-for-the-detection-of-rabies-virus-antigen-or-nucleic-acid-in-brain-samples-of-animals-suspected-of-rabies-in-india
#16
K Nithin Prabhu, Shrikrishna Isloor, B Hanchinal Veeresh, Doddamane Rathnamma, R Sharada, Lekshmi J Das, M L Satyanarayana, Nagendra R Hegde, Sira Abdul Rahman
Accurate and early diagnosis of animal rabies is critical for undertaking public health measures. Whereas the direct fluorescent antibody (DFA) technique is the recommended test, the more convenient, direct rapid immunochemistry test (dRIT), as well as the more sensitive, reverse transcription polymerase chain reaction (RT-PCR), have recently been employed for the laboratory diagnosis of rabies. We compared the three methods on brain samples from domestic (dog, cat, cattle, buffalo, horse, pig and goat) and wild (leopard, wolf and jackal) animals from various parts of India...
February 28, 2018: Veterinary Sciences
https://www.readbyqxmd.com/read/29397017/steroid-therapy-in-children-with-fulminant-hepatitis-a
#17
H M Zakaria, T A Salem, H A El-Araby, R M Salama, D Y Elbadry, A M Sira, M A Ali, M E Salem, B M Abd-Alaaty, S S Goda, S M Eltaras, F O Khalil, S S Abou-Zeinah, M M Sira
Fulminant hepatic failure is a life-threatening disease. Hepatitis A virus (HAV) can cause fulminant hepatic failure and death in about 0.2% of cases. Extensive destruction of infected hepatocytes by immune-mediated lysis is thought to be the cause. We aimed to evaluate the use of steroid therapy in children with fulminant HAV. This study included 33 children with fulminant HAV in two groups. Steroid group: comprised of 18 children who received prednisolone (1 mg/kg/d) or its equivalent dose of methylprednisolone, and the nonsteroid group: comprised another 15 children who did not receive steroid therapy...
February 3, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29391557/smarca2-regulated-host-cell-factors-are-required-for-mxa-restriction-of-influenza-a-viruses
#18
Dominik Dornfeld, Alexandra H Dudek, Thibaut Vausselin, Sira C Günther, Judd F Hultquist, Sebastian Giese, Daria Khokhlova-Cubberley, Yap C Chew, Nevan J Krogan, Adolfo Garcia-Sastre, Martin Schwemmle, Megan L Shaw
The human interferon (IFN)-induced MxA protein is a key antiviral host restriction factor exhibiting broad antiviral activity against many RNA viruses, including highly pathogenic avian influenza A viruses (IAV) of the H5N1 and H7N7 subtype. To date the mechanism for how MxA exerts its antiviral activity is unclear, however, additional cellular factors are believed to be essential for this activity. To identify MxA cofactors we performed a genome-wide siRNA-based screen in human airway epithelial cells (A549) constitutively expressing MxA using an H5N1 reporter virus...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29365771/effect-of-the-p-arg357his-mutation-of-pcsk9-on-basal-and-postprandial-lipoprotein-metabolism
#19
Mathilde Varret, Marianne Abifadel, Athina Despina Kalopissis, Sira Fatoumata Maiga, Gilles Lambert, Nabil G Seidah, Catherine Boileau, Michele Chabert
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29356178/programmed-death-ligand-1-expression-as-immunotherapeutic-target-in-sinonasal-cancer
#20
Cristina Riobello, Blanca Vivanco, Sara Reda, Alejandro López-Hernández, Cristina García-Inclán, Sira Potes-Ares, Virginia N Cabal, Fernando López, José Luis Llorente, Mario A Hermsen
BACKGROUND: Sinonasal cancer carries a poor prognosis, especially in recurrent stages, and it is a disease with very limited treatment options. METHODS: The expression of programmed death ligand-1 (PD-L1) as a marker for immunotherapy was evaluated in 53 sinonasal squamous cell carcinoma (SCC) and 126 intestinal-type adenocarcinoma (ITAC) samples. Results were correlated to clinicopathological characteristics and follow-up data. RESULTS: Membranous PD-L1 staining of tumor cells was observed in 34% (18/53) of the sinonasal SCC samples and in 17% (22/126) of the ITAC samples...
April 2018: Head & Neck
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