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https://www.readbyqxmd.com/read/29777165/hiv-1-proteins-dysregulate-motivational-processes-and-dopamine-circuitry
#1
Sarah J Bertrand, Charles F Mactutus, Steven B Harrod, Landhing M Moran, Rosemarie M Booze
Motivational alterations, such as apathy, in HIV-1+ individuals are associated with decreased performance on tasks involving frontal-subcortical circuitry. We used the HIV-1 transgenic (Tg) rat to assess effect of long-term HIV-1 protein exposure on motivated behavior using sucrose (1-30%, w/v) and cocaine (0.01-1.0 mg/kg/infusion) maintained responding with fixed-ratio (FR) and progressive-ratio (PR) schedules of reinforcement. For sucrose-reinforced responding, HIV-1 Tg rats displayed no change in EC50 relative to controls, suggesting no change in sucrose reinforcement but had a downward shifted concentration-response curves, suggesting a decrease in response vigor...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29776700/assessment-of-the-utility-of-ordering-a-troponin-in-low-and-intermediate-risk-patients-presenting-to-the-emergency-department-with-supraventricular-tachycardia-a-retrospective-chart-review
#2
David Noorvash, Rosemarie Ramos, Linda Hatch, Andrew Muck, Adriana Segura Olson
BACKGROUND: A troponin assay is commonly sent for patients presenting to emergency departments (EDs) with supraventricular tachycardia (SVT). Multiple studies suggest that elevated troponin levels do not predict coronary artery disease in these patients. Patients with elevated troponins are more likely to have additional cardiac testing, which can lead to increased health care costs and unnecessary invasive procedures. OBJECTIVE: Our objective was to evaluate low- to intermediate-risk patients (HEART [history, electrocardiography, age, risk factors and troponin] Score 1-6) presenting to the ED with SVT...
May 15, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29774424/lingual-and-jaw-kinematic-abnormalities-precede-speech-and-swallowing-impairments-in-als
#3
Bridget J Perry, Rosemary Martino, Yana Yunusova, Emily K Plowman, Jordan R Green
Early identification of bulbar involvement in persons with ALS is critical for improving diagnosis and prognosis; however, efficacious diagnostic markers have not yet been identified. The purpose of this study was to determine whether kinematic changes of the tongue and jaw during swallowing, measured using 3D electromagnetic articulography (EMA), predate clinically identifiable symptoms of speech and swallowing impairment in persons diagnosed with ALS. Data were collected from 16 adults diagnosed with ALS and 18 neurotypical controls...
May 17, 2018: Dysphagia
https://www.readbyqxmd.com/read/29774038/altered-expression-of-the-malate-permeable-anion-channel-osalmt4-reduces-the-growth-of-rice-under-low-radiance
#4
Jie Liu, Muyun Xu, Gonzalo M Estavillo, Emmanuel Delhaize, Rosemary G White, Meixue Zhou, Peter R Ryan
We examined the function of OsALMT4 in rice ( Oryza sativa L.) which is a member of the aluminum-activated malate transporter family. Previous studies showed that OsALMT4 localizes to the plasma membrane and that expression in transgenic rice lines results in a constitutive release of malate from the roots. Here, we show that OsALMT4 is expressed widely in roots, shoots, flowers, and grain but not guard cells. Expression was also affected by ionic and osmotic stress, light and to the hormones ABA, IAA, and salicylic acid...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29774022/acute-zika-virus-infection-in-an-endemic-area-shows-modest-proinflammatory-systemic-immunoactivation-and-cytokine-symptom-associations
#5
Jéssica Barletto de Sousa Barros, Paulo Alex Neves da Silva, Rosemary de Carvalho Rocha Koga, Patrícia Gonzalez-Dias, José Rodrigues Carmo Filho, Patrícia Resende Alo Nagib, Verônica Coelho, Helder I Nakaya, Simone Gonçalves Fonseca, Irmtraut Araci Hoffmann Pfrimer
An early immune response to Zika virus (ZIKV) infection may determine its clinical manifestation and outcome, including neurological effects. However, low-grade and transient viremia limits the prompt diagnosis of acute ZIKV infection. We have investigated the plasma cytokine, chemokine, and growth factor profiles of 36 individuals from an endemic area displaying different symptoms such as exanthema, headache, myalgia, arthralgia, fever, hyperemia, swelling, itching, and nausea during early-phase infection...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29773958/failing-to-thrive-abdominal-pain-and-vomiting-a-hairy-situation
#6
EDITORIAL
Victoria A Au, Jonathan P Wong, Isvarya Venu, Rosemary G Moodie, Yousef Etoom, Luke Kieswetter, J Ted Gerstle, Peter D Wong
No abstract text is available yet for this article.
May 2018: Paediatrics & Child Health
https://www.readbyqxmd.com/read/29772940/assistive-technology-and-people-a-position-paper-from-the-first-global-research-innovation-and-education-on-assistive-technology-great-summit
#7
Deirdre Desmond, Natasha Layton, Jacob Bentley, Fleur Heleen Boot, Johan Borg, Bishnu Maya Dhungana, Pamela Gallagher, Lynn Gitlow, Rosemary Joan Gowran, Nora Groce, Katerina Mavrou, Trish Mackeogh, Rachael McDonald, Cecilia Pettersson, Marcia Scherer
Assistive technology (AT) is a powerful enabler of participation. The World Health Organization's Global Collaboration on Assistive Technology (GATE) programme is actively working towards access to assistive technology for all. Developed through collaborative work as a part of the Global Research, Innovation and Education on Assistive Technology (GREAT) Summit, this position paper provides a "state of the science" view of AT users, conceptualized as "People" within the set of GATE strategic "P"s...
May 17, 2018: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29772939/enabling-appropriate-personnel-skill-mix-for-progressive-realization-of-equitable-access-to-assistive-technology
#8
Emma M Smith, Rosemary Joan Gowran, Hasheem Mannan, Brian Donnelly, Liliana Alvarez, Diane Bell, Silvana Contepomi, Liezel Ennion Wegner, Evert-Jan Hoogerwerf, Tracey Howe, Yih-Kuen Jan, Jeanne Kagwiza, Natasha Layton, Ritchard Ledgerd, Malcolm MacLachlan, Giulia Oggero, Cecilia Pettersson, Thais Pousada, Elsje Scheffler, Sam Wu
BACKGROUND AND METHODS: This paper reviews the current capacity of personnel in enabling access to assistive technology (AT) as well as the systems and processes within which they work, and was reviewed, discussed, and refined during and following the Global Research, Innovation, and Education in Assistive Technology (GREAT) Summit. FINDINGS: Key concepts addressed include a person-centred team approach; sustainability indicators to monitor, measure, and respond to needs for service design and delivery; education, research, and training for competent practice, using the six rehab-workforce challenges framework; and credentialing frameworks...
May 17, 2018: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29772814/chronic-and-occult-hepatitis-b-virus-infection-in-pregnant-women-in-botswana
#9
Tshepiso Mbangiwa, Ishmael Kasvosve, Motswedi Anderson, Prisca K Thami, Wonderful T Choga, Austen Needleman, Bonolo B Phinius, Sikhulile Moyo, Melvin Leteane, Jean Leidner, Jason T Blackard, Gloria Mayondi, Betsy Kammerer, Rosemary M Musonda, Max Essex, Shahin Lockman, Simani Gaseitsiwe
The hepatitis B virus (HBV) is a global problem; however, the burden of HBV infection in pregnant women in Botswana is unknown. We sought to determine the prevalence of chronic and occult HBV infection in human immunodeficiency virus (HIV)-infected and -uninfected pregnant women in Botswana. Samples from 752 pregnant women were tested for hepatitis B surface antigen (HBsAg), and HBsAg-positive samples were tested for hepatitis B e antigen (HBeAg) and HBV DNA load. Samples that were HBsAg negative were screened for occult HBV infection by determining the HBV DNA load...
May 17, 2018: Genes
https://www.readbyqxmd.com/read/29772031/stresses-in-implant-supported-fixed-complete-dentures-with-different-screw-tightening-sequences-and-torque-application-modes
#10
Leonardo H Barcellos, Marina Lobato Palmeiro, Marcos M Naconecy, Tomás Geremia, André Cervieri, Rosemary S Shinkai
PURPOSE: To compare the effects of different screw-tightening sequences and torque applications on stresses in implant-supported fixed complete dentures supported by five abutments. MATERIALS AND METHODS: Strain gauges fixed to the abutments were used to test the sequences 2-4-3-1-5; 1-2-3-4-5; 3-2-4-1-5; and 2-5-4-1-3 with direct 10-Ncm torque or progressive torque (5 + 10 Ncm). Data were analyzed using analysis of variance and standardized effect size. RESULTS: No effects of tightening sequence or torque application were found except for the sequence 3-2-4-1-5 and some small to moderate effect sizes...
May 17, 2018: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/29771781/lack-of-virological-suppression-among-young-hiv-positive-adults-in-botswana
#11
Vlad Novitsky, Tendani Gaolathe, Mompati Mmalane, Sikhulile Moyo, Unoda Chakalisa, Etienne Kadima Yankinda, Tafireyi Marukutira, Molly Pretorius Holme, Tumalano Sekoto, Simani Gaseitsiwe, Rosemary Musonda, Erik van Widenfelt, Kathleen M Powis, Nealia Khan, Scott Dryden-Peterson, Kara Bennett, Kathleen E Wirth, Eric Tchetgen Tchetgen, Pam Bachanas, Lisa A Mills, Refeletswe Lebelonyane, El-Halabi Shenaaz, Joseph Makhema, Shahin Lockman, M Essex
BACKGROUND: HIV-1 RNA load is the best biological predictor of HIV transmission and treatment response. The rate of virologic suppression among key sub-populations can guide HIV prevention programs. METHODS: The Botswana Combination Prevention Project performed a population-based household survey among adults in 30 communities in Botswana. Data collected included knowledge of HIV-positive status, ART coverage and virologic suppression (HIV-1 RNA ≤400 copies/mL)...
April 27, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29766127/grey-s-anatomy-effect-television-portrayal-of-patients-with-trauma-may-cultivate-unrealistic-patient-and-family-expectations-after-injury
#12
Rosemarie O Serrone, Jordan A Weinberg, Pamela W Goslar, Erin P Wilkinson, Terrell M Thompson, Jonathan L Dameworth, Shawna R Dempsey, Scott R Petersen
Background: Expectations of the healthcare experience may be influenced by television dramas set in the hospital workplace. It is our perception that the fictional television portrayal of hospitalization after injury in such dramas is misrepresentative. The purpose of this study was to compare trauma outcomes on television dramas versus reality. Methods: We screened 269 episodes of Grey's Anatomy , a popular medical drama. A television (TV) registry was constructed by collecting data for each fictional trauma portrayed in the television series...
2018: Trauma surgery & acute care open
https://www.readbyqxmd.com/read/29765519/long-noncoding-rnas-are-associated-with-metabolic-and-cellular-processes-in-the-jejunum-mucosa-of-pre-weaning-calves-in-response-to-different-diets
#13
Rosemarie Weikard, Frieder Hadlich, Harald M Hammon, Doerte Frieten, Caroline Gerbert, Christian Koch, Georg Dusel, Christa Kuehn
Long noncoding RNAs (lncRNAs) emerged as important regulatory component of mechanisms involved in gene expression, chromatin modification and epigenetic processes, but they are rarely annotated in the bovine genome. Our study monitored the jejunum transcriptome of German Holstein calves fed two different milk diets using transcriptome sequencing (RNA-seq). To identify potential lncRNAs within the pool of unknown transcripts, four bioinformatic lncRNA prediction tools were applied. The intersection of the alignment-free lncRNA prediction tools (CNCI, PLEK and FEELnc) predicted 1,812 lncRNA transcripts concordantly comprising a catalogue of 1,042 putative lncRNA loci expressed in the calves' intestinal mucosa...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29764892/intense-exercise-for-survival-among-men-with-metastatic-castrate-resistant-prostate-cancer-interval-gap4-a-multicentre-randomised-controlled-phase-iii-study-protocol
#14
Robert U Newton, Stacey A Kenfield, Nicolas H Hart, June M Chan, Kerry S Courneya, James Catto, Stephen P Finn, Rosemary Greenwood, Daniel C Hughes, Lorelei Mucci, Stephen R Plymate, Stephan F E Praet, Emer M Guinan, Erin L Van Blarigan, Orla Casey, Mark Buzza, Sam Gledhill, Li Zhang, Daniel A Galvão, Charles J Ryan, Fred Saad
INTRODUCTION: Preliminary evidence supports the beneficial role of physical activity on prostate cancer outcomes. This phase III randomised controlled trial (RCT) is designed to determine if supervised high-intensity aerobic and resistance exercise increases overall survival (OS) in patients with metastatic castrate-resistant prostate cancer (mCRPC). METHODS AND ANALYSIS: Participants (n=866) must have histologically documented metastatic prostate cancer with evidence of progressive disease on androgen deprivation therapy (defined as mCRPC)...
May 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29764330/factors-influencing-the-provision-of-fertility-counseling-and-impact-on-quality-of-life-in-adolescents-and-young-adults-with-cancer
#15
Gemma Skaczkowski, Victoria White, Kate Thompson, Helen Bibby, Michael Coory, Lisa M Orme, Rachel Conyers, Marianne B Phillips, Michael Osborn, Rosemary Harrup, Antoinette Anazodo
PURPOSE: This study investigated the impact of fertility-related discussions on Adolescent and Young Adult (AYA) cancer patients' quality of life (QoL) and the factors influencing provision of these discussions. METHODS: Recruitment was conducted through population-based state cancer registries. Eligible AYAs were 15-24 years at diagnosis, 3-24 months postdiagnosis, with any cancer (except early stage melanoma). As part of a larger survey, AYAs were asked about their experiences of fertility-related discussions and QoL (FACT-G)...
May 15, 2018: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/29763992/development-of-an-algorithm-to-identify-pregnancy-episodes-and-related-outcomes-in-health-care-claims-databases-an-application-to-antiepileptic-drug-use-in-4-9-million-pregnant-women-in-france
#16
Pierre-Olivier Blotière, Alain Weill, Marie Dalichampt, Cécile Billionnet, Myriam Mezzarobba, Fanny Raguideau, Rosemary Dray-Spira, Mahmoud Zureik, Joël Coste, François Alla
PURPOSE: Access to claims databases provides an opportunity to study medication use and safety during pregnancy. We developed an algorithm to identify pregnancy episodes in the French health care databases and applied it to study antiepileptic drug (AED) use during pregnancy between 2007 and 2014. METHODS: The algorithm searched the French health care databases for discharge diagnoses and medical procedures indicative of completion of a pregnancy. To differentiate claims associated with separate pregnancies, an interval of at least 28 weeks was required between 2 consecutive pregnancies resulting in a birth and 6 weeks for terminations of pregnancy...
May 15, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29763508/withdrawn-nursing-record-systems-effects-on-nursing-practice-and-healthcare-outcomes
#17
REVIEW
Christine Urquhart, Rosemary Currell, Maria J Grant, Nicholas R Hardiker
BACKGROUND: A nursing record system is the record of care that was planned or given to individual patients and clients by qualified nurses or other caregivers under the direction of a qualified nurse. Nursing record systems may be an effective way of influencing nurse practice. OBJECTIVES: To assess the effects of nursing record systems on nursing practice and patient outcomes. SEARCH METHODS: For the original version of this review in 2000, and updates in 2003 and 2008, we searched: the Cochrane Effective Practice and Organisation of Care (EPOC) Group Specialised Register; MEDLINE, EMBASE, CINAHL, BNI, ISI Web of Knowledge, and ASLIB Index of Theses...
May 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29763498/effect-of-avocado-soybean-unsaponifiables-asu-on-osseointegration-in-rats-with-experimental-arthritis
#18
Luiz Guilherme Freitas de Paula, Guilherme José Pimentel Lopes de Oliveira, Felipe Eduardo Pinotti, Bruna Biagioni Grecchi, Sabrina Garcia de Aquino, Rosemary Adriana Chiérici Marcantonio
PURPOSE: To evaluate the influence of the use of avocado/soybean unsaponifiables (ASU) on osseointegration of implants in animals with experimental arthritis. MATERIALS AND METHODS: One hundred twenty rats were randomly divided into four groups: CTR, healthy animals and saline solution administration; ASU, healthy animals and ASU administration; ART, arthritic animals and saline solution administration; and ART/ASU, arthritic animals and ASU administration. The solutions were administered daily by gavage, beginning 7 days before the surgical procedures until the completion of the experimental period (15, 30, and 60 days after the placement of the implants in the tibia)...
May 2018: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29762709/determinants-of-%C3%AE-herpesvirus-shedding-in-saliva-among-ugandan-children-and-their-mothers
#19
Robert Newton, Nazzarena Labo, Katie Wakeham, Vickie Marshall, Romin Roshan, Angela Nalwoga, Ismail Sebina, Lawrence Muhangi, Emily L Webb, Wendell Miley, Rosemary Rochford, Alison M Elliott, Denise Whitby
Introduction: Epstein Barr Virus (EBV) and Kaposi's sarcoma associated herpesvirus (KSHV) are transmitted via saliva but factors associated with salivary shedding are unknown. Methods: We measured the shedding of both viruses in the saliva of ~500 Ugandan mothers and their six-year old children, testing all participants for EBV and KSHV seropositive individuals for KSHV. Results: EBV and KSHV were shed by 72% and 22% of the mothers, and by 85% and 40% of children, respectively; boys were more likely than girls to shed KSHV (48% versus 30%), but not EBV...
May 12, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29761590/the-interaction-of-anti-diabetic-%C3%AE-glucosidase-inhibitors-and-gut-bacteria-%C3%AE-glucosidase
#20
Kemin Tan, Christine Tesar, Rosemarie Wilton, Robert P Jedrzejczak, Andrzej Joachimiak
Carbohydrate hydrolyzing α-glucosidases are commonly found in microorganisms present in the human intestine microbiome. We have previously reported crystal structures of an α-glucosidase from the human gut bacterium Blaubia (Ruminococcus) obeum (Ro-αG1) and its substrate preference/specificity switch. This novel member of the GH31 family is a structural homolog of human intestinal maltase-glucoamylase (MGAM) and sucrase-isomaltase (SI) with a highly conserved active site that is predicted to be common in Ro-αG1 homologs among other species that colonize the human gut...
May 15, 2018: Protein Science: a Publication of the Protein Society
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