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https://www.readbyqxmd.com/read/28102020/families-experiences-of-involvement-in-care-planning-in-mental-health-services-an-integrative-literature-review
#1
REVIEW
Owen Doody, Mary Pat Butler, Rosemary Lyons, Daniel Newman
INTRODUCTION: Mental health service policy stipulates that family carers be involved in care planning. AIM: To identify families experiences of care planning involvement in adult mental health services. METHOD: An integrative review where electronic databases and grey literature were searched for papers published between 01 Jan 2005 and 10 February 2016. RESULTS: Fifteen papers met the inclusion criteria. Thematic analysis generated three themes: (1)families experience of collaboration, (2)families perceptions of professionals and (3)families impressions of the care planning process...
January 19, 2017: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/28098945/frequency-of-cnksr2-mutation-in-the-x-linked-epilepsy-aphasia-spectrum
#2
John A Damiano, Rosemary Burgess, Sara Kivity, Tally Lerman-Sagie, Zaid Afawi, Ingrid E Scheffer, Samuel F Berkovic, Michael S Hildebrand
Synaptic proteins are critical to neuronal function in the brain, and their deficiency can lead to seizures and cognitive impairments. CNKSR2 (connector enhancer of KSR2) is a synaptic protein involved in Ras signaling-mediated neuronal proliferation, migration and differentiation. Mutations in the X-linked gene CNKSR2 have been described in patients with seizures and neurodevelopmental deficits, especially those affecting language. In this study, we sequenced 112 patients with phenotypes within the epilepsy-aphasia spectrum (EAS) to determine the frequency of CNKSR2 mutation within this complex set of disorders...
January 18, 2017: Epilepsia
https://www.readbyqxmd.com/read/28096513/targeting-tnfr2-with-antagonistic-antibodies-inhibits-proliferation-of-ovarian-cancer-cells-and-tumor-associated-tregs
#3
Heather Torrey, John Butterworth, Toshiyuki Mera, Yoshiaki Okubo, Limei Wang, Danielle Baum, Audrey Defusco, Sara Plager, Sarah Warden, Daniel Huang, Eva Vanamee, Rosemary Foster, Denise L Faustman
Major barriers to cancer therapy include the lack of selective inhibitors of regulatory T cells (Tregs) and the lack of broadly applicable ways to directly target tumors through frequently expressed surface oncogenes. Tumor necrosis factor receptor 2 (TNFR2) is an attractive target protein because of its restricted abundance to highly immunosuppressive Tregs and oncogenic presence on human tumors. We characterized the effect of TNFR2 inhibition using antagonistic antibodies. In culture-based assays, we found that two TNFR2 antagonists inhibited Treg proliferation, reduced soluble TNFR2 secretion from normal cells, and enabled T effector cell expansion...
January 17, 2017: Science Signaling
https://www.readbyqxmd.com/read/28095647/new-generation-mass-spectrometry-expands-the-toolbox-of-cell-and-developmental-biology
#4
REVIEW
Camille Lombard-Banek, Erika P Portero, Rosemary M Onjiko, Peter Nemes
Systems cell biology understanding of development requires characterization of all the molecules produced in the biological system. Decades of research and new-generation sequencing provided functional information on key genes and transcripts. However, there is less information available on how differential gene expression translates into the domains of functionally important proteins, peptides, and metabolites, and how changes in these molecules impact development. Mass spectrometry (MS) is the current technology of choice for the detection and quantification of large numbers of proteins and metabolites, because it requires no use of antibodies, functional probes, or a priori knowledge of molecules produced in the system...
January 17, 2017: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/28095133/trauma-exposure-and-disordered-eating-a-qualitative-study
#5
Jessica Y Breland, Rosemary Donalson, Julie V Dinh, Shira Maguen
Quantitative studies have demonstrated a positive association between trauma exposure and disordered eating. However, reasons for this relationship are unclear. We used qualitative methods to understand why some individuals exposed to trauma report disordered eating. We conducted five focus groups and two dyadic interviews between Spring 2013 and Fall 2014 with women at a Veterans Health Administration medical center (N = 20). Most participants were recruited from outpatient mental health clinics. Participants completed demographic and psychological questionnaires...
January 17, 2017: Women & Health
https://www.readbyqxmd.com/read/28094544/red-wine-and-pomegranate-extracts-suppress-cured-meat-promotion-of-colonic-mucin-depleted-foci-in-carcinogen-induced-rats
#6
Nadia M Bastide, Nathalie Naud, Gilles Nassy, Jean-Luc Vendeuvre, Sylviane Taché, Françoise Guéraud, Ditte A Hobbs, Gunter G Kuhnle, Denis E Corpet, Fabrice H F Pierre
Processed meat intake is carcinogenic to humans. We have shown that intake of a workshop-made cured meat with erythorbate promotes colon carcinogenesis in rats. We speculated that polyphenols could inhibit this effect by limitation of endogenous lipid peroxidation and nitrosation. Polyphenol-rich plant extracts were added to the workshop-made cured meat and given for 14 days to rats and 100 days to azoxymethane-induced rats to evaluate the inhibition of preneoplastic lesions. Colons of 100-d study were scored for precancerous lesions (mucin-depleted foci, MDF), and biochemical end points of peroxidation and nitrosation were measured in urinary and fecal samples...
January 17, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28093936/biological-activities-of-rosmarinus-officinalis-l-rosemary-extract-as-analyzed-in-microorganisms-and-cells
#7
Jonatas Rafael de Oliveira, Daiane de Jesus, Leandro Wagner Figueira, Felipe Eduardo de Oliveira, Cristina Pacheco Soares, Samira Estves Afonso Camargo, Antonio Olavo Cardoso Jorge, Luciane Dias de Oliveira
R. officinalis L. is an aromatic plant commonly used as condiment and for medicinal purposes. Biological activities of its extract were evaluated in this study, as antimicrobial effect on mono- and polymicrobial biofilms, cytotoxicity, anti-inflammatory capacity, and genotoxicity. Monomicrobial biofilms of Candida albicans, Staphylococcus aureus, Enterococcus faecalis, Streptococcus mutans and Pseudomonas aeruginosa and polymicrobial biofilms composed of C. albicans with each bacterium were formed in microplates during 48 h and exposed for 5 min to R...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28093333/characterization-of-oral-disintegrating-film-of-peanut-skin-extract-potential-route-for-buccal-delivery-of-phenolic-compounds
#8
Marcela Tedesco, Carla Monaco, Rosemary A Carvalho
This paper aimed to develop and characterize oral disintegrating films (ODF) based on gelatin and hydroxypropyl methylcellulose (HPMC) incorporated with peanut skin extract (PSE) as phenolic compounds vehicle. Films were prepared by casting technique varying the polymer ratio (GEL:HPMC 100:0, 25:75, 50:50, 75:25, 0:100) and PSE concentration (20 and 30g/100g film-forming solution). Formulations with high content of gelatin presented insoluble complex possibly due to cross-linking between gelatin and polyphenols...
January 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28093019/prophylactic-and-curative-effect-of-rosemary-leaves-extract-in-a-bleomycin-model-of-pulmonary-fibrosis
#9
Sana Bahri, Ridha Ben Ali, Khaoula Gasmi, Mona Mlika, Saloua Fazaa, Riadh Ksouri, Raja Serairi, Saloua Jameleddine, Vadim Shlyonsky
CONTEXT: Pulmonary fibrosis is a devastating disease without effective treatment. Rosemary is appreciated since ancient times for its medicinal properties, while biomolecules originated from the plant have an antioxidant and antifibrotic effect. OBJECTIVE: The effects of Rosmarinus officinalis L. (Lamiaceae) leaves extract (RO) on bleomycin-induced lung fibrosis were investigated. MATERIALS AND METHODS: Male Wistar rats were given a single dose of bleomycin (BLM, 4 mg/kg, intratracheal), while RO (75 mg/kg, intraperitoneal) was administered 3 days later and continued for 4 weeks (BLM/RO1-curative group)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28092220/using-teledentistry-in-clinical-practice-an-enabler-to-improve-access-to-oral-health-care-a-qualitative-systematic-review
#10
Michelle Irving, Rosemary Stewart, Heiko Spallek, Anthony Blinkhorn
Background Access to dental care is important for overall health, but can remain problematic for those in rural or isolated locations. It can be difficult to encourage clinicians to choose or continue a rural health career. Teledentistry is showing some promise as a strategy to support rural, isolated and new health care workers. This study aims to explore the quantitative and qualitative framework associated with teledentistry in an effort to uncover the interaction of multiple influences on its delivery and sustainability...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/28092065/impact-of-celecoxib-on-inflammation-during-cancer-surgery-a-randomized-clinical-trial
#11
Jonathan G Hiller, Shienny Sampurno, Rosemary Millen, Niketh Kuruvilla, Kwok M Ho, Rob Ramsay, Bernhard Riedel
PURPOSE: During cancer surgery, prostaglandin-mediated inflammation may promote and activate micrometastatic disease with a consequent increase in long-term cancer recurrence. Cyclooxygenase-2 inhibitors, known to have anti-proliferative properties, may offset such perioperative perturbation. We investigated the effectiveness of these agents to minimize inflammatory changes during cancer surgery. METHODS: Following ethics approval, 32 patients who were to undergo major intracavity cancer surgery were enrolled in this prospective, randomized, clinical trial...
January 13, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28089675/burden-of-clostridium-difficile-infection-associated-hospitalization-in-a-cohort-of-middle-aged-and-older-adults
#12
Yingxi Chen, Kathryn Glass, Bette Liu, Rosemary J Korda, Thomas V Riley, Martyn D Kirk
BACKGROUND: Clostridium difficile is the principal cause of infectious diarrhea in hospitalized patients. The aim of this study was to describe and compare length of stay (LOS), costs, and in-hospital deaths for C difficile infection (CDI) and non-CDI hospitalizations, in a cohort of middle-aged and older Australians. METHODS: We used survey data from the 45 and Up Study, linked to hospitalization and death data. We calculated the average LOS and costs per hospitalization, and the proportion of in-hospital deaths for CDI and non-CDI hospitalizations...
January 13, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28089405/use-of-essential-oils-following-traumatic-burn-injury-a-case-study
#13
Kathleen Jopke, Heather Sanders, Rosemary White-Traut
Hospital admissions related to burn injury reach 40,000 annually. Patients who experience extensive burns require longer hospital stays and are at increased risk for infection and hospital acquired conditions. This comparative case study is a two patient matched case control design that follows the hospital course of two children who experienced burn injuries. For one of these patients, with the consent of the child's parents, the grandmother treated her granddaughter with essential oils. Essential oils have the potential to inhibit microbial growth, support treatment of wounds, and facilitate healing...
January 13, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28079245/gastric-and-jejunal-histopathological-changes-in-patients-undergoing-bariatric-surgery
#14
Rosemary Simões Nomelini Rodrigues, Élia Cláudia de Souza Almeida, Júverson Alves Terra, Lucinda Calheiros Guimarães, Ana Cristina da Rocha Duque, Renata Margarida Etchebehere
BACKGROUND: - Morbid obesity is a multifactorial disease that is increasingly treated by surgery. OBJECTIVE: - To evaluate gastric histopathological changes in obese, and to compare with patients who underwent gastrojejunal bypass and the jejunal mucosa after the surgery. METHODS: - This is an observational study performed at a tertiary public hospital, evaluating endoscopic biopsies from 36 preoperative patients and 35 postoperative. RESULTS: - In the preoperative group, 80...
January 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28079007/novel-therapies-targeting-cardioprotection-and-regeneration
#15
Valeria Garrido, Evelyn Mendoza-Torres, Jaime A Riquelme, Ariel Díaz, Marcela Pizarro, Mario Bustamante, Myra N Chavez, María Paz Ocaranza, Rosemarie Mellado, Ramon Corbalan, Miguel L Allende, Sergio Lavandero
Cardiovascular disease is the leading cause of death worldwide. The heart is susceptible to pathologies that impact the myocardium directly, such myocardial infarction and consequent heart failure, as well as conditions with indirect cardiac effects, such cancer treatment-related cardiotoxicity. As the contractile cells of the heart, cardiomyocytes are essential for normal cardiac function. Various stress stimuli may result in transient damage or cell death in cardiomyocytes through apoptosis, necrosis or maladaptive autophagy...
January 12, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28078168/concurrent-validity-of-caffeine-problems-and-diagnostic-criteria-for-substance-use-disorders
#16
Elizabeth Harstad, Georgios Sideridis, Lon Sherritt, Lydia A Shrier, Rosemary Ziemnik, Sharon Levy
Background: The DSM-5 proposes caffeine use disorder (CUD) as a condition for further study. The objective of this study was to report on the prevalence of CUD and rates of endorsement for each substance use disorder (SUD) criterion in relation to caffeine compared to alcohol and marijuana in a sample of adolescents presenting for medical care in the primary, adolescent, and substance use clinics at an academic medical center. Methods: A convenience sample of patients (N = 213; 66.7% female) aged 12-17 presenting for medical care completed the Composite Diagnostic Interview-Substance Abuse Module questionnaire, with questions regarding use of caffeine, alcohol, and marijuana...
December 1, 2016: Journal of Caffeine Research
https://www.readbyqxmd.com/read/28076737/absolute-risk-of-cardiovascular-disease-events-and-blood-pressure-and-lipid-lowering-therapy-in-australia
#17
Emily Banks, Rosemary J Korda, Bill Stavreski
No abstract text is available yet for this article.
January 16, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28076663/synthesis-and-biological-evaluation-of-novel-amidinourea-and-triazine-congeners-as-inhibitors-of-mda-mb-231-human-breast-cancer-cell-proliferation
#18
Daniele Castagnolo, Rosemary Bass, Sarah Jenkinson, Jennifer Wright, Tora Smulders-Srinivasan, Jamie C Marshall
A series of novel amidinourea derivatives has been synthesised and the new compounds have been evaluated as inhibitors of MDA-MB-231 human breast cancer cell proliferation. In addition, a second series of triazine derivatives designed as rigid congeners of the amidinoureas was synthesised as well and the compounds were evaluated for their antiproliferative activity. Among the two series, the amidinourea 3d emerged as a potent anticancer hit compound with IC50 = 0.76 micormolar comparable to tamoxifen.
January 11, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28074741/efficiency-of-rosemary-and-basil-essential-oils-on-the-shelf-life-extension-of-atlantic-mackerel-scomber-scombrus-fillets-stored-at-2%C3%A2-c
#19
Romdhane Karoui, Abdo Hassoun
The objective of the present study was to evaluate the impact of rosemary and basil essential oils (EOs) on the qualityof Atlantic mackerel fillets stored at 2°C up to 15 days. Atlantic mackerel (<em>Scomber scombrus</em>) fillets were periodically evaluated to assess their textural, color, physicochemical, and spectral characteristics. The results indicated that rosemary and basil treatments were effective for inhibiting the formation of total volatile basic nitrogen (TVB-N) and lipid oxidation products during storage...
January 11, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28073909/the-detection-of-spotted-fever-group-rickettsia-dna-in-tick-samples-from-pastoral-communities-in-kenya
#20
Hellen Koka, Rosemary Sang, Helen Lydia Kutima, Lillian Musila
In this study, ticks from pastoral communities in Kenya were tested for Rickettsia spp. infections in geographical regions where the presence of tick-borne arboviruses had previously been reported. Rickettsial and arbovirus infections have similar clinical features which makes differential diagnosis challenging when both diseases occur. The tick samples were tested for Rickettsia spp. by conventional PCR using three primer sets targeting the gltA, ompA, and ompB genes followed by amplicon sequencing. Of the tick pools screened, 25% (95/380) were positive for Rickettsia spp...
January 10, 2017: Journal of Medical Entomology
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