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Hypocitraturia

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https://www.readbyqxmd.com/read/27905491/changes-in-urinary-metabolomic-profile-during-relapsing-renal-vasculitis
#1
Bahjat Al-Ani, Martin Fitzpatrick, Hamad Al-Nuaimi, Alice M Coughlan, Fionnuala B Hickey, Charles D Pusey, Caroline Savage, Christopher M Benton, Eóin C O'Brien, Declan O'Toole, Ken H Mok, Stephen P Young, Mark A Little
Current biomarkers of renal disease in systemic vasculitis lack predictive value and are insensitive to early damage. To identify novel biomarkers of renal vasculitis flare, we analysed the longitudinal urinary metabolomic profile of a rat model of anti-neutrophil cytoplasmic antibody (ANCA) vasculitis. Wistar-Kyoto (WKY) rats were immunised with human myeloperoxidase (MPO). Urine was obtained at regular intervals for 181 days, after which relapse was induced by re-challenge with MPO. Urinary metabolites were assessed in an unbiased fashion using nuclear magnetic resonance (NMR) spectroscopy, and analysed using partial least squares discriminant analysis (PLS-DA) and partial least squares regression (PLS-R)...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27872836/urolithiasis-in-inflammatory-bowel-disease-and-bariatric-surgery
#2
Agapios Gkentzis, Michael Kimuli, Jon Cartledge, Olivier Traxer, Chandra Shekhar Biyani
AIM: To analyse current literature focusing on pathogenesis and therapeutic aspects of urolithiasis with inflammatory bowel disease (IBD) and following bariatric surgery. METHODS: A systematic literature search was performed using PubMed, supplemented with additional references. Studies assessing the association of IBD or bariatric surgery with renal stones in both paediatric and adulthood were included. RESULTS: Certain types of stones are seen more frequently with IBD...
November 6, 2016: World Journal of Nephrology
https://www.readbyqxmd.com/read/27865972/paediatric-urolithiasis-in-emerging-economies
#3
REVIEW
S Adibul Hasan Rizvi, Sajid Sultan, Mirza Naqi Zafar, Sadaf Aba Umar, Bashir Ahmed, S A Anwar Naqvi
BACKGROUND: Paediatric urolithiasis remains endemic in low resource countries. This review highlights the epidemiology, causation and management of urolithiasis in an Asian country in the context of emerging economies. METHODS: A literature review of recent articles with key words paediatric urolithiasis, developing countries, endemic stone disease, stone composition, metabolic risk factors, management of paediatric urolithiasis was undertaken and 51 relevant articles were selected with the main focus on experience of this center in managing stone disease in the last two decades...
November 16, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27847289/nephrolithiasis-after-bariatric-surgery-a-review-of-pathophysiologic-mechanisms-and-procedural-risk
#4
REVIEW
Umer Hasan Bhatti, Andrew J Duffy, Kurt Eric Roberts, Amir Hafeez Shariff
Obesity alone is a known risk factor for nephrolithiasis, and bariatric surgery has been linked to a higher incidence of post-operative new-onset nephrolithiasis. The mean interval from bariatric surgery to diagnosis of nephrolithiasis, ranges from 1.5 to 3.6 years. The stone risk is greatest for purely malabsorptive procedures, intermediate for Roux-en-Y gastric bypass and lowest for purely restrictive procedures (laparoscopic adjustable gastric banding, laparoscopic sleeve gastrectomy) where it approaches or is reduced below that of non-operative obese controls...
November 12, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27744630/metabolic-risk-factors-in-pediatric-stone-formers-a-report-from-an-emerging-economy
#5
Kiran Imran, Mirza Naqi Zafar, Uzma Ozair, Sadia Khan, Syed Adibul Hasan Rizvi
The goal of this study was to investigate metabolic risk factors in pediatric stone formers in an emerging economy. A prospective, data collection enrolled 250 children age <1-15 years at our center. Risk factors were evaluated by gender and in age groups <1-5, 6-10 and 11-15 years. Patients were evaluated for demographics, blood and 24 h urine for calcium, magnesium, phosphate, uric acid, electrolytes and additional protein, citrate, ammonia and oxalate in urine. All reported values were two sided and statistical significance was considered at p value ≤0...
October 15, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27639591/evidence-for-epistatic-interaction-between-vdr-and-slc13a2-genes-in-the-pathogenesis-of-hypocitraturia-in-recurrent-calcium-oxalate-stone-formers
#6
Domenico Rendina, Gianpaolo De Filippo, Fernando Gianfrancesco, Riccardo Muscariello, Michele Schiano di Cola, Pasquale Strazzullo, Teresa Esposito
BACKGROUND: Genetic factors play a key role in the pathogenesis of hypocitraturia, a common risk factor for nephrolithiasis. The Na(+)-dicarboxylate cotransporter NaDC1, encoded by the sodium-dicarboxylate cotransporter (SLC13A2) gene, is a major determinant of urinary citrate excretion and its biological functions are regulated also by the vitamin D/Vitamin D receptor (VDR) biological system. The aim of this case-control study was to evaluate the possible epistatic interaction between VDR (rs731236)and SLC13A2 (rs11567842) allelic variants in the pathogenesis of hypocitraturia...
September 17, 2016: Journal of Nephrology
https://www.readbyqxmd.com/read/27622279/the-challenge-of-cystine-and-struvite-stone-formers-clinical-metabolic-and-surgical-assessment
#7
Kleiton G R Yamaçake, Giovanni S Marchini, Sabrina Reis, Alexandre Danilovic, Fábio C Vicentini, Fábio C M Torricelli, Miguel Srougi, Eduardo Mazzucchi
PURPOSE: To compare the clinical, metabolic, and calculi characteristics of cystine and struvite stone patients after percutaneous nephrolithotripsy (PCNL). MATERIAL AND METHODS: Between January/2006-July/2013, 11 cystine stone patients were treated in our clinic. Of those, 3 were excluded due to incomplete follow-up. Eight cystine stone patients (2 with bilateral disease; 10 renal units-RU) were considered for further analysis. A cohort of 8 struvite stone formers (10RU) was matched having the same age, gender, body mass index (BMI) and Guys stone score...
September 1, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27598490/-lithogenic-risk-in-patients-from-paraguay-with-urolithiasis
#8
Patricia Funes, Gloria Echagüe, Irene Ruiz, Lourdes Rivas, Jorge Zenteno, Rosa Guillén
UNLABELLED: The lithogenic risk profile is a graphical representation of metabolic factors and urinary saturation involved in the stone formation with their respective critical values. AIM: To determine the lithogenic risk profile in patients with urolithiasis. MATERIAL AND METHODS: Personal data such as anthropometric, history of diseases and family history of urolithiasis were recorded. Different compounds acting as promoters or inhibitors of crystallization were measured in serum and urine samples, and the data obtained were used to calculate urinary saturation using Equil software...
June 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/27510800/metabolic-disturbances-in-chinese-children-with-urolithiasis-a-single-center-report
#9
Dong Yang, Hans-Göran Tiselius, Chuangxin Lan, Dong Chen, Kang Chen, Lili Ou, Yang Liu, Shaohong Xu, Guohua Zeng, Ming Lei, Wenqi Wu
Urinary stones and urine composition are the first steps in the process of recurrence prevention, but data concerning the association between the two compositions are scarce in Chinese children with urolithiasis. We retrospectively analyzed the records of children (age range 0-18 years) with urolithiasis in our center between March 2004 and December 2013. Stone analysis was carried out in 382 children and 24-hour urine analysis in 80 children. Analysis of both stone and 24-hour urine composition was completed in 56 children...
August 10, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27430498/-pathogenic-factors-in-calcium-oxalate-stones-epidemiological-investigation
#10
H Kaaroud El Jery, A Harzallah, S Chouchi, E Talbi, H Baccouch, J Abdelmoula, A Bouzouita, M Chebil, F Ben Hamida, T Ben Abdallah
INTRODUCTION: Calcium oxalate stones are the most common urolithiasis. Changes in dietary habits, socio-economic and health status of populations explain its progression. The aim of our study was to determine metabolic factors leading to lithiasis and clarify its causes. PATIENTS AND METHODS: This is a retrospective study of 100 patients with calcium oxalate stones identified by morpho-constitutional study, collected in our department over a period of 5 years (2008-2013)...
June 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27286123/are-patients-with-lichen-planus-really-prone-to-urolithiasis-lichen-planus-and-urolithiasis
#11
Ural Oguz, Zennure Takci, Isil Deniz Oguz, Berkan Resorlu, Ilknur Balta, Ali Unsal
PURPOSE: to investigate whether patients with lichen planus (LP) are really prone to urolithiasis or not. PATIENTS AND METHODS: We performed a prospective analysis of 40 patients diagnosed with lichen planus (LP) (group I), and 40 volunteers did not have LP before (group II). Participants were all checked for urolithiasis by radiological investigations. Blood samples were analyzed for biochemistry parameters including calcium and uric acid. 24-h urine samples were analyzed to investigate oxalate, citrate calcium, uric acid, magnesium, sodium and creatinine...
May 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27247958/mutations-in-atp6v1b1-and-atp6v0a4-genes-cause-recessive-distal-renal-tubular-acidosis-in-mexican-families
#12
Laura I Escobar, Christopher Simian, Cyrielle Treard, Donia Hayek, Carolina Salvador, Norma Guerra, Mario Matos, Mara Medeiros, Sandra Enciso, María Dolores Camargo, Rosa Vargas-Poussou
BACKGROUND: Autosomal recessive distal renal tubular acidosis (dRTA) is a rare disease characterized by a hyperchloremic metabolic acidosis with normal anion gap, hypokalemia, hypercalciuria, hypocitraturia, nephrocalcinosis, and conserved glomerular filtration rate. In some cases, neurosensorial deafness is associated. dRTA is developed during the first months of life and the main manifestations are failure to thrive, vomiting, dehydration, and anorexia. METHODS: Nine unrelated families were studied: seven children, a teenager, and an adult with dRTA...
May 2016: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/27098938/metabolic-features-and-renal-outcomes-of-urolithiasis-in-children
#13
Sang Taek Lee, Heeyeon Cho
AIM: The incidence of pediatric urolithiasis has increased over the last century because of dietary changes, metabolic abnormalities, climate change, and genitourinary abnormalities. Data on pediatric urolithiasis in non-endemic countries are limited. The aim of this study was to evaluate the clinical findings and metabolic etiology of urolithiasis in Korean children. MATERIAL AND METHODS: The medical records of 73 Korean children who were newly diagnosed with urolithiasis from January 2010 to December 2013 were retrospectively analyzed...
July 2016: Renal Failure
https://www.readbyqxmd.com/read/27033084/endoscopic-description-of-renal-papillary-abnormalities-in-stone-disease-by-flexible-ureteroscopy-a-proposed-classification-of-severity-and-type
#14
Christophe Almeras, Michel Daudon, Guillaume Ploussard, Jean Romain Gautier, Olivier Traxer, Paul Meria
INTRODUCTION: The goal of this original work was to describe papillary abnormalities using flexible ureteroscopy into a new classification and to assess their relation with stone composition. PATIENTS AND METHODS: We performed a prospective monocentric single-operator study aiming to describe various aspects of renal papillae. Data have been prospectively collected during consecutive 164 sequential flexible ureterorenoscopies required for the treatment of renal stones from May 2011 to March 2015...
March 31, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/26959969/use-of-urinary-concentrations-in-mg-dl-in-relation-to-absolute-values-in-24-hour-samples-for-the-evaluation-of-lithogenic-factors-in-stone-forming-patients
#15
M A Arrabal-Polo, M C Cano-García, G Hidalgo-Agullo, L Roletto-Salmo
OBJECTIVE: The aim of this study is to analyze urine concentrations (mg/dl) of different lithogenic factors in a sample of 24 h as a predictor of these changes rather than absolute values depend on the volume of diuresis. METHODS: A total of 131 patients from the North Almeria Health Management Area (Spain) with urinary calstone disease in whom a metabolic study was indicated were included from June 2014 to May 2015. The concentrations of calcium, oxalate, uric acid, citrate and magnesium were measured in the urine, and the calcium/citrate ratio was calculated...
March 2016: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/26914114/pears-and-renal-stones-possible-weapon-for-prevention-a-comprehensive-narrative-review
#16
REVIEW
R Manfredini, A De Giorgi, A Storari, F Fabbian
Urinary stones have been recognized as a human disease since dawn of history and treatment of this condition is reported by Egyptian medical writings. Also, pears have a very long history, being one of the earliest cultivated fruit trees and also known for medicinal use. Urinary tract stone formation represents a common condition and also a significant burden for health care service, due also to possible frequent relapses. Furthermore, urinary stones have been reported to have relationship with different metabolic derangements, and appropriate diet could contribute to avoid or reduce urinary stone formation...
2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/26913725/metabolic-risk-factors-in-children-with-asymptomatic-hematuria
#17
Francisco Rodolfo Spivacow, Elisa Elena Del Valle, Paula Gabriela Rey
BACKGROUND: Idiopathic or benign hematuria is diagnosed in children after all other possible causes have been ruled out and test results for renal or urologic pathologies are negative. METHODS: To identify possible urinary risk factors for hematuria in children, we retrospectively evaluated clinical onset, family history, and metabolic risk factors of 60 children with idiopathic hematuria but without renal stones or other pathologic conditions that could explain the hematuria...
July 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/26887717/re-alkali-replacement-raises-urinary-citrate-excretion-in-patients-with-topiramate-induced-hypocitraturia
#18
COMMENT
Dean G Assimos
No abstract text is available yet for this article.
March 2016: Journal of Urology
https://www.readbyqxmd.com/read/26859947/-diagnosis-of-metabolic-disorders-and-metaphylaxis-of-recurrent-calcium-oxalate-urolithiasis
#19
A V Kustov, A L Strelnikov, A O Airapetyan, M A Moryganov, N I Zhuravleva
The paper presents the results of the 1-year screening of biochemical parameters of urine in female patient with recurrent calcium urate urolithiasis. Based on the data of quantitative X-ray phase analysis of the composition of stone and a complex of clinical and laboratory examination, reasons for recurrent stone formation were determined. The main reasons included hypocitraturia, hyperosmolarity of urine and uric acid diathesis. Therapy with citrate mixtures and adequate water schedule (daily urine--2-2.5 liters) for 10 weeks allowed to increase the urinary pH, led to 2...
September 2015: Urologii︠a︡
https://www.readbyqxmd.com/read/26582172/potassium-citrate-decreases-urine-calcium-excretion-in-patients-with-hypocitraturic-calcium-oxalate-nephrolithiasis
#20
Yan Song, Natalia Hernandez, Jonathan Shoag, David S Goldfarb, Brian H Eisner
Two previous studies (<10 patients each) have demonstrated that alkali therapy may reduce urine calcium excretion in patients with calcium oxalate nephrolithiasis. The hypothesized mechanisms are (1) a decrease in bone turnover due to systemic alkalinization by the medications; (2) binding of calcium by citrate in the gastrointestinal tract; (3) direct effects on TRPV5 activity in the distal tubule. We performed a retrospective review of patients on potassium citrate therapy to evaluate the effects of this medication on urinary calcium excretion...
April 2016: Urolithiasis
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