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https://www.readbyqxmd.com/read/29615808/long-term-western-diet-fed-apolipoprotein-e-deficient-rats-exhibit-only-modest-early-atherosclerotic-characteristics
#1
Ida Rune, Bidda Rolin, Jens Lykkesfeldt, Dennis Sandris Nielsen, Łukasz Krych, Jenny E Kanter, Karin E Bornfeldt, Pernille Kihl, Karsten Buschard, Knud Josefsen, Johannes Josef Fels, Alan Mortensen, Berit Christoffersen, Rikke Kaae Kirk, Axel Kornerup Hansen
In the apolipoprotein E-deficient mouse, the gut microbiota has an impact on the development of atherosclerosis, but whether such correlations are also present in rats requires investigation. Therefore, we studied female SD-Apoetm1sage (Apoe-/- ) rats fed either a Western diet or a low-fat control diet with or without gluten, which is known to promote gut microbiota changes, until 20 weeks of age. We hypothesized that the manifestation of atherosclerosis would be more severe in Apoe-/- rats fed the Western high-fat diet, as compared with rats fed the low-fat diet, and that atherosclerosis would be accelerated by gluten...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29601505/a-community-driven-approach-to-generate-urban-policy-recommendations-for-obesity-prevention
#2
Julia Díez, Pedro Gullón, María Sandín Vázquez, Belén Álvarez, María Del Prado Martín, María Urtasun, Maite Gamarra, Joel Gittelsohn, Manuel Franco
There is an increasing research interest in targeting interventions at the neighborhood level to prevent obesity. Healthy urban environments require including residents' perspectives to help understanding how urban environments relate to residents' food choices and physical activity levels. We describe an innovative community-driven process aimed to develop environmental recommendations for obesity prevention. We conducted this study in a low-income area in Madrid (Spain), using a collaborative citizen science approach...
March 30, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29594339/obesogenic-habits-among-children-and-their-families-in-response-to-initiation-of-gluten-free-diet
#3
Neriya Levran, Michael Wilschanski, Jessica Livovsky, Edna Shachar, Moti Moskovitz, Lama Assaf-Jabrin, Eyal Shteyer
Initiation of a lifelong, gluten-free diet (GFD) in children with celiac disease (CD) influences the child's life in many ways. The aim of this study was to assess the influence of GFD on the child and his/her family's eating habits and lifestyle behaviors. To study this, we asked children and their parents completed the Family Eating and Activity Habits Questionnaire (FEAHQ) at the time of diagnosis of CD and at least 6 months after initiation of GFD and a questionnaires assessing symptoms related to CD and adherence to the GFD diet...
March 29, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29459801/the-effect-of-gluten-free-diet-among-celiac-patients-aged-3-12-years-old-on-bmi-during-2006-to-2014-at-nemazee-teaching-hospital
#4
Seyed Mohsen Dehghani, Sedighe Ostovar, Maryam Ataollahi, Hazhir Javaherizadeh
INTRODUCTION: Celiac disease (CD) is increasingly diagnosed and weight changes are common after adoption of a glutenfree diet (GFD) and there is concern that patients might gain further weight on a GFD. OBJECTIVES: This study examined to evaluate the impact of a GFD on the body mass index (BMI), whether favorable or unfavorable. MATERIALS AND METHODS: In this retrospective study, we reviewed electronic records of 44 patients with serologic study and intestinal biopsy confirmed CD who was visited in Nemazee hospital, Shiraz...
October 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/29392873/gluten-free-diet-during-pregnancy-alleviates-signs-of-diabetes-and-celiac-disease-in-nod-mouse-offspring
#5
Martin Haupt-Jorgensen, Jesper Larsen, Knud Josefsen, Tina Z Jørgensen, Julie Christine Antvorskov, Axel K Hansen, Karsten Buschard
BACKGROUND: Gluten-free (GF) diet during pregnancy ameliorates autoimmune diabetes in nonobese diabetic (NOD) mouse offspring. Due to comorbidity of celiac disease in type 1 diabetes, we hypothesized that GF diet in utero alleviates the humoral and histopathological signs of celiac disease in NOD mice. We aimed to establish the mechanisms behind the diabetes-protective effect of GF diet in utero. METHODS: Breeding pairs of NOD mice were fed a GF or gluten-containing standard (STD) diet until parturition...
February 2, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29378512/is-perceived-intolerance-to-milk-and-wheat-associated-with-the-corresponding-igg-and-iga-food-antibodies-a-cross-sectional-study-in-subjects-with-morbid-obesity-and-gastrointestinal-symptoms
#6
Anne Stine Kvehaugen, Dag Tveiten, Per G Farup
BACKGROUND: Serum IgG and IgA food antibodies have been used for dietary advice to subjects with gastrointestinal symptoms and perceived food intolerance, but the role of these antibodies in mediating intolerance is controversial. The present study investigated associations between perceived gastrointestinal intolerance to milk-or wheat and the corresponding s-IgG and s-IgA food antibodies in subjects with morbid obesity. METHODS: Subjects with morbid obesity (BMI ≥ 40 kg/m2 or ≥35 kg/m2 with obesity-related complications) were included...
January 30, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29040812/a-randomized-controlled-crossover-study-of-appetite-related-sensations-after-consuming-snacks-made-from-buckwheat
#7
Danielle M Defries, Jay C Petkau, Terri Gregor, Heather Blewett
With the rising incidence of overweight and obesity in developed countries, there is an interest in developing food products that may aid in satiety and reduce energy intake. Buckwheat (Fagopyrum esculentum) is a gluten-free edible seed that has been previously shown to induce changes in postprandial concentrations of satiety hormones; however, subjective measures of appetite-related sensations and objective measures of energy intake at subsequent meals following buckwheat consumption have not been measured...
February 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28828296/cardiometabolic-risk-factors-in-children-with-celiac-disease-on-a-gluten-free-diet
#8
REVIEW
Caterina Anania, Lucia Pacifico, Francesca Olivero, Francesco Massimo Perla, Claudio Chiesa
Celiac disease (CD) is an immune-mediated systemic condition evoked by gluten and related prolamines in genetically predisposed subjects. It is characterised by a variable combination of gluten-dependent clinical symptoms, CD-specific antibodies, HLA-DQ2 and HLA-DQ8 haplotypes, and enteropathy. The only therapy of CD consists of a life-long gluten free diet (GFD). Strict GFD adherence results in full clinical, serological and histological remission, avoiding long-term complications in CD patients. However, this diet is not without problems...
August 8, 2017: World Journal of Clinical Pediatrics
https://www.readbyqxmd.com/read/28700675/occupation-with-grain-crops-is-associated-with-lower-type-1-diabetes-incidence-registry-based-case-control-study
#9
Martin Haupt-Jorgensen, Erik Nielsen, Kåre Engkilde, Mia Lerche, Jesper Larsen, Karsten Buschard
Intranasal administration of gliadin prevents autoimmune diabetes in non-obese diabetic mice. The current study was designed to investigate if bakers are intranasally exposed to gluten during work and whether occupation as baker is inversely associated with type 1 diabetes. Gliadin was measured in nasal swabs from eight bakers and butchers. The odds ratio of type 1 diabetes in selected profession groups was analysed in a registry-based case-control study with data from 1980 to 2010 derived from Statistics Denmark...
2017: PloS One
https://www.readbyqxmd.com/read/28639127/obesity-metabolic-syndrome-and-cardiac-risk-factors-going-gluten-free-for-better-or-worse
#10
EDITORIAL
Louise Emilsson, Carol E Semrad
No abstract text is available yet for this article.
September 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28451915/obesity-metabolic-syndrome-and-cardiovascular-risk-in-gluten-free-followers-without-celiac-disease-in-the-united-states-results-from-the-national-health-and-nutrition-examination-survey-2009-2014
#11
Hyun-Seok Kim, Michael F Demyen, Justin Mathew, Neil Kothari, Mirela Feurdean, Sushil K Ahlawat
BACKGROUND: Despite unclear benefits of gluten-free diets (GFD) in the general population, gluten-free followers without medical indications are driving the market. Few studies have investigated health benefits of GFD in the general population. AIMS: To estimate metabolic and cardiovascular disease (CVD) risk profiles among gluten-free followers without celiac disease (CD). METHODS: Data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2009-2014...
September 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28300220/effects-of-gliadin-consumption-on-the-intestinal-microbiota-and-metabolic-homeostasis-in-mice-fed-a-high-fat-diet
#12
Li Zhang, Daniel Andersen, Henrik Munch Roager, Martin Iain Bahl, Camilla Hartmann Friis Hansen, Niels Banhos Danneskiold-Samsøe, Karsten Kristiansen, Ilinca Daria Radulescu, Christian Sina, Henrik Lauritz Frandsen, Axel Kornerup Hansen, Susanne Brix, Lars I Hellgren, Tine Rask Licht
Dietary gluten causes severe disorders like celiac disease in gluten-intolerant humans. However, currently understanding of its impact in tolerant individuals is limited. Our objective was to test whether gliadin, one of the detrimental parts of gluten, would impact the metabolic effects of an obesogenic diet. Mice were fed either a defined high-fat diet (HFD) containing 4% gliadin (n = 20), or a gliadin-free, isocaloric HFD (n = 20) for 23 weeks. Combined analysis of several parameters including insulin resistance, histology of liver and adipose tissue, intestinal microbiota in three gut compartments, gut barrier function, gene expression, urinary metabolites and immune profiles in intestinal, lymphoid, liver and adipose tissues was performed...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28135975/a-diet-enriched-with-red-sorghum-flaked-biscuits-compared-to-a-diet-containing-white-wheat-flaked-biscuits-does-not-enhance-the-effectiveness-of-an-energy-restricted-meal-plan-in-overweight-and-mildly-obese-adults
#13
RANDOMIZED CONTROLLED TRIAL
Anita Stefoska-Needham, Eleanor J Beck, Stuart K Johnson, Marijka J Batterham, Ross Grant, John Ashton, Linda C Tapsell
OBJECTIVES: Whole grain sorghum is a promising ingredient in foods, especially those targeting satiety and weight control. This study aimed to test weight loss effects of a whole grain red sorghum product incorporated into an energy-restricted diet. METHODS: Sixty subjects (46 females) were randomized to either a sorghum (intervention) or white wheat (control) group, receiving 45 g of flaked cereal biscuits to include daily in their prescribed diets for 12 weeks...
March 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28092152/issues-in-nutrition-dietary-considerations-in-select-chronic-conditions
#14
REVIEW
Margaret E Thompson, Mary Barth Noel
Chronic diseases that affect the gastrointestinal tract also tend to affect nutrition. The incidence of chronic liver disease is increasing. As the prevalence of obesity rises, so do the incidences of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Patients with chronic liver disease usually have some degree of malnutrition. In the absence of encephalopathy, patients with chronic liver disease should consume more protein than that in the average diet. There is some controversy about whether diet plays a role in the development of inflammatory bowel disease...
January 2017: FP Essentials
https://www.readbyqxmd.com/read/27763627/human-intestinal-barrier-function-in-health-and-disease
#15
REVIEW
Julia König, Jerry Wells, Patrice D Cani, Clara L García-Ródenas, Tom MacDonald, Annick Mercenier, Jacqueline Whyte, Freddy Troost, Robert-Jan Brummer
The gastrointestinal tract consists of an enormous surface area that is optimized to efficiently absorb nutrients, water, and electrolytes from food. At the same time, it needs to provide a tight barrier against the ingress of harmful substances, and protect against a reaction to omnipresent harmless compounds. A dysfunctional intestinal barrier is associated with various diseases and disorders. In this review, the role of intestinal permeability in common disorders such as infections with intestinal pathogens, inflammatory bowel disease, irritable bowel syndrome, obesity, celiac disease, non-celiac gluten sensitivity, and food allergies will be discussed...
October 20, 2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/27566421/progress-in-pediatrics-in-2015-choices-in-allergy-endocrinology-gastroenterology-genetics-haematology-infectious-diseases-neonatology-nephrology-neurology-nutrition-oncology-and-pulmonology
#16
REVIEW
Carlo Caffarelli, Francesca Santamaria, Dora Di Mauro, Carla Mastrorilli, Virginia Mirra, Sergio Bernasconi
This review focuses key advances in different pediatric fields that were published in Italian Journal of Pediatrics and in international journals in 2015. Weaning studies continue to show promise for preventing food allergy. New diagnostic tools are available for identifying the allergic origin of allergic-like symptoms. Advances have been reported in obesity, short stature and autoimmune endocrine disorders. New molecules are offered to reduce weight gain and insulin-resistance in obese children. Regional investigations may provide suggestions for preventing short stature...
August 27, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27334430/celiac-disease-understanding-the-gluten-free-diet
#17
REVIEW
Karla A Bascuñán, María Catalina Vespa, Magdalena Araya
PURPOSE: The only effective and safe treatment of celiac disease (CD) continues being strict exclusion of gluten for life, the so-called gluten-free diet (GFD). Although this treatment is highly successful, following strict GFD poses difficulties to patients in family, social and working contexts, deteriorating his/her quality of life. We aimed to review main characteristics of GFD with special emphasis on factors that may interfere with adherence to it. METHODS: We conducted a search of various databases, such as PubMed, Google Scholar, Embase, and Scielo, with focus on key words such as "gluten-free diet", "celiac disease", "gluten" and "gluten-free diet adherence"...
March 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/27171408/celiac-disease-related-inflammation-is-marked-by-reduction-of-nkp44-nkp46-double-positive-natural-killer-cells
#18
Irene Marafini, Ivan Monteleone, Davide Di Fusco, Silvia Sedda, Maria Laura Cupi, Daniele Fina, Alessandro Omero Paoluzi, Francesco Pallone, Giovanni Monteleone
INTRODUCTION AND AIM: Natural killer (NK) cells are a first line of defence against viruses and down-regulation of NK cell cytotoxic receptors represents one of the strategies by which viruses escape the host's immune system. Since onset of celiac disease (CD), a gluten-driven enteropathy, has been associated with viral infections, we examined whether CD-associated inflammation is characterized by abnormal distribution of NK cell receptors involved in recognition of viral-infected cells...
2016: PloS One
https://www.readbyqxmd.com/read/26991675/gluten-free-diet-increases-beta-cell-volume-and-improves-glucose-tolerance-in-an-animal-model-of-type-2-diabetes
#19
COMPARATIVE STUDY
Martin Haupt-Jorgensen, Karsten Buschard, Axel K Hansen, Knud Josefsen, Julie Christine Antvorskov
BACKGROUND: Gluten-free (GF) diet alleviates type 1 diabetes in animal models and possibly in humans. We recently showed that fatty acid-induced insulin secretion is enhanced by enzymatically digested gluten (gliadin) stimulation in INS-1E insulinoma cells. We therefore hypothesized that GF diet would induce beta-cell rest and ameliorate type 2 diabetes. METHODS: C57BL/6JBomTac (B6) mice were fed a high-fat (HF), gluten-free high-fat (GF-HF), standard (STD) or gluten-free (GF) diet for 42 weeks...
October 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/26941586/do-we-need-to-worry-about-eating-wheat
#20
P R Shewry, S J Hey
Wheat is a staple food throughout the temperate world and an important source of nutrients for many millions of people. However, the last few years have seen increasing concerns about adverse effects of wheat on health, particularly in North America and Europe, with the increasing adoption of wheat-free or gluten-free diets. This relates to two concerns: that wheat products are disproportionally responsible for increases in obesity and type 2 diabetes and that wheat gluten proteins cause a range of adverse reactions, including allergies, coeliac disease and 'non-coeliac gluten sensitivity'...
March 2016: Nutrition Bulletin
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