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Preventive Psychiatry

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https://www.readbyqxmd.com/read/28809400/prenatal-one-carbon-metabolism-dysregulation-programs-schizophrenia-like-deficits
#1
A Alachkar, L Wang, R Yoshimura, A R Hamzeh, Z Wang, N Sanathara, S M Lee, X Xu, G W Abbott, O Civelli
The methionine-folate cycle-dependent one-carbon metabolism is implicated in the pathophysiology of schizophrenia. Since schizophrenia is a developmental disorder, we examined the effects that perturbation of the one-carbon metabolism during gestation has on mice progeny. Pregnant mice were administered methionine equivalent to double their daily intake during the last week of gestation. Their progeny (MET mice) exhibited schizophrenia-like social deficits, cognitive impairments and elevated stereotypy, decreased neurogenesis and synaptic plasticity, and abnormally reduced local excitatory synaptic connections in CA1 neurons...
August 15, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28809398/precision-medicine-for-suicidality-from-universality-to-subtypes-and-personalization
#2
A B Niculescu, H Le-Niculescu, D F Levey, P L Phalen, H L Dainton, K Roseberry, E M Niculescu, J O Niezer, A Williams, D L Graham, T J Jones, V Venugopal, A Ballew, M Yard, T Gelbart, S M Kurian, A Shekhar, N J Schork, G E Sandusky, D R Salomon
Suicide remains a clear, present and increasing public health problem, despite being a potentially preventable tragedy. Its incidence is particularly high in people with overt or un(der)diagnosed psychiatric disorders. Objective and precise identification of individuals at risk, ways of monitoring response to treatments and novel preventive therapeutics need to be discovered, employed and widely deployed. We sought to investigate whether blood gene expression biomarkers for suicide (that is, a 'liquid biopsy' approach) can be identified that are more universal in nature, working across psychiatric diagnoses and genders, using larger cohorts than in previous studies...
August 15, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28805175/outcomes-of-a-psycho-education-and-monitoring-programme-to-prevent-compulsory-admission-to-psychiatric-inpatient-care-a-randomised-controlled-trial
#3
B Lay, W Kawohl, W Rössler
BACKGROUND: There is a need for interventions that effectively reduce compulsory admission to psychiatry. We conducted a randomised controlled trial to investigate whether an innovative intervention programme prevents compulsory re-admission in people with serious mental illness. METHODS: The programme addresses primarily patients' self-management skills. It consists of individualised psychoeducation focusing on behaviours prior to and during illness-related crises, crisis cards and, after discharge from the psychiatric hospital, a 24-month preventive monitoring...
August 14, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28805124/migration-violence-and-the-role-of-psychiatry-in-italy
#4
Antonio Ventriglio, Antonello Bellomo, Giovanna Vitrani, Eleonora Stella, Alessandro Gentile, Dinesh Bhugra
Immigration to Italy has been increasing exponentially in the last decades due to the international political changes and conflicts in the Middle East. The relationship between immigration and crimes is a debated issue, and violent radicalization of second or third generations of migrants is under increased scrutiny. Consequently, many politicians and political parties use nationalist and xenophobic language. Inevitably, this will have an impact on reactions of the larger population, as well as that of migrants...
August 2017: International Review of Psychiatry
https://www.readbyqxmd.com/read/28801871/pediatric-delirium-evaluation-management-and-special-considerations
#5
REVIEW
Nasuh Malas, Khyati Brahmbhatt, Cristin McDermott, Allanceson Smith, Roberto Ortiz-Aguayo, Susan Turkel
Delirium describes a syndrome of acute brain dysfunction with severe consequences on patient outcomes, medical cost, morbidity, and mortality. It represents a final common pathway of numerous pathophysiologic disturbances disrupting cerebral homeostasis. The diagnosis is predicated on recognition of the clinical features of the syndrome through ongoing clinical assessment. Early identification can be aided by routine screening, particularly in high-risk populations. Evaluation and management are continuous and simultaneous processes involving a multidisciplinary care team including child psychiatry consultation...
August 12, 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28801755/a-cross-national-comparison-of-violence-among-young-men-in-china-and-the-uk-psychiatric-and-cultural-explanations
#6
Jeremy Coid, Junmei Hu, Constantinos Kallis, Yuan Ping, Juying Zhang, Yueying Hu, Laura Bui, Simone Ullrich, Paul Bebbington
PURPOSE: Public health psychiatry has a key role in violence prevention. Cross-national comparisons of violence and associated psychiatric morbidity can indicate targets for preventive interventions. METHOD: Data on young adult men in households, 18-34 years, were drawn from the Second Men's Modern Lifestyles survey in Great Britain (n = 2046) and from a corresponding survey in Chengdu, China (n = 4132), using a translated questionnaire. Binary logistic regression models were carried out to estimate the cross-national differences for different types of violence and to identify explanatory variables...
August 11, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28797262/when-a-parent-dies-a-systematic-review-of-the-effects-of-support-programs-for-parentally-bereaved-children-and-their-caregivers
#7
Ann-Sofie Bergman, Ulf Axberg, Elizabeth Hanson
BACKGROUND: The death of a parent is a highly stressful life event for bereaved children. Several studies have shown an increased risk of mental ill-health and psychosocial problems among affected children. The aims of this study were to systematically review studies about effective support interventions for parentally bereaved children and to identify gaps in the research. METHODS: The review's inclusion criteria were comparative studies with samples of parentally bereaved children...
August 10, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/28777243/systematic-evaluation-of-commercial-pharmacogenetic-testing-in-psychiatry-a-focus-on-cyp2d6-and-cyp2c19-allele-coverage-and-results-reporting
#8
Chad A Bousman, Philip Jaksa, Christos Pantelis
OBJECTIVE: The aim of this study was to systematically assess commercial pharmacogenetic tests relevant to prescribing in psychiatry, with specific attention on CYP2D6 and CYP2C19 star allele coverage as well as compliance with consensus recommendations for pharmacogenetic test result reporting. MATERIALS AND METHODS: The CYP2D6 and CY2C19 star (*) allele contents of 20 pharmacogenetic test panels were compared and their test results reports were evaluated on the basis of consensus reporting recommendations published by The Centers for Disease Control and Prevention as well as the Clinical Pharmacogenetics Implementation Consortium...
August 2, 2017: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/28762507/increasing-physical-activity-for-veterans-in-the-mental-health-intensive-case-management-program-a-community-based-intervention
#9
S Akeya Harrold, Julian Libet, Charlene Pope, Joy A Lauerer, Emily Johnson, Barbara J Edlund
AIMS AND OBJECTIVES: Individuals with severe mental illness (SMI), experience increased mortality-20 years greater disparity for men and 15 years greater disparity for women-compared to the general population (Thornicroft G. Physical health disparities and mental illness: The scandal of premature mortality. Br J Psychiatr. 2011;199:441-442). Numerous factors contribute to premature mortality in persons with SMI, including suicide and accidental death (Richardson RC, Faulkner G, McDevitt J, Skrinar GS, Hutchinson D, Piette JD...
August 1, 2017: Perspectives in Psychiatric Care
https://www.readbyqxmd.com/read/28761082/selective-activation-of-parvalbumin-interneurons-prevents-stress-induced-synapse-loss-and-perceptual-defects
#10
C-C Chen, J Lu, R Yang, J B Ding, Y Zuo
Stress, a prevalent experience in modern society, is a major risk factor for many psychiatric disorders. Although sensorimotor abnormalities are often present in these disorders, little is known about how stress affects the sensory cortex. Combining behavioral analyses with in vivo synaptic imaging, we show that stressful experiences lead to progressive, clustered loss of dendritic spines along the apical dendrites of layer (L) 5 pyramidal neurons (PNs) in the mouse barrel cortex, and such spine loss closely associates with deteriorated performance in a whisker-dependent texture discrimination task...
August 1, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28758522/explanatory-models-and-distress-in-primary-caregivers-of-patients-with-acute-psychotic-presentations-a-study-from-south-india
#11
Deepa S Joy, S D Manoranjitham, P Samuel, K S Jacob
BACKGROUND: Emotional distress among caregivers of people with mental illness is common, changes overtime and requires appropriate coping strategies to prevent long-term disability. Explanatory models, which underpin understanding of disease and illness, are crucial to coping. AIM: To study the association of explanatory models and distress among caregivers of people with acute psychotic illness. METHOD: A total of 60 consecutive patients and their primary caregivers who presented to the Department of Psychiatry, Christian Medical College, Vellore, were recruited for the study...
July 1, 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28752249/-treatment-structures-for-men-with-pedosexual-problems
#12
REVIEW
Georg Stolpmann, Peer Briken, Jürgen L Müller
Pedophilia is defined as a persistent or dominating sexual preference for prepubescent children characterized by persistent thoughts, fantasies, urges, sexual arousal and behavior. Less than 50% of all child abusers fulfill the diagnostic criteria and an even smaller part exclusively has a preference for children. Following psychiatric classification systems, pedophilia must be distinguished from child sexual abuse. Outpatient treatment and treatment in forensic psychiatry clinics, sociotherapeutic facilities and in correction facilities are different aspects of prevention...
July 27, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28714650/-stigmatisation-a-widespread-problem-with-multiple-consequences
#13
Nicole Bichsel, Philippe Conus
Stigmatisation is a well known social phenomenon based on the discrimination of an individual or a sub-group of individuals by a dominant or majority group. Often discussed in the frame of psychiatry, it is also observed in other domains of medicine. It impacts not only patients, but their relatives and their children, as well as the health professionals taking care of them. Moreover, it is detrimental to the implementation of preventive strategies and induces depressive reactions, loss of self esteem and reduction of patients' quality of life...
February 22, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28714115/editorial-let-s-talk-about-sex-the-gender-binary-revisited
#14
EDITORIAL
Albertine J Oldehinkel
Sex refers to biological differences and gender to socioculturally delineated masculine and feminine roles. Sex or gender are included as a covariate or effect modifier in the majority of child psychology and psychiatry studies, and differences found between boys and girls have inspired many researchers to postulate underlying mechanisms. Empirical tests of whether including these proposed explanatory variables actually reduces the variance explained by gender are lagging behind somewhat. That is a pity, because a lot can be gained from a greater focus on the active agents of specific gender differences...
August 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28713080/clinical-and-psychopathological-characteristics-of-the-autoagressive-behavior-in-patients-with-the-first-psychotic-episode-with-considering-circadian-rhythms
#15
Dmytro I Boiko, Lilia V Zhyvotovska, Grigorij T Sonnik, Andrij M Skrypnіkov
INTRODUCTION: The high rate of autoagressive action in patients with psychotic symptoms manifested during the beginning of active psychopharmatherapy, and they are often the reason for psychiatric help. The continuous growth of autoagressive behavior indicates the number of unsolved problems in clinical suicidology. AIM: The aim of this research was to explore the clinical and psychopathological characteristics of the autoagressive behavior in patients with the first psychotic episode with considering circadian rhythms...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28696430/neuropathology-of-suicide-recent-findings-and-future-directions
#16
P-E Lutz, N Mechawar, G Turecki
Suicide is a major public health concern and a leading cause of death in most societies. Suicidal behaviour is complex and heterogeneous, likely resulting from several causes. It associates with multiple factors, including psychopathology, personality traits, early-life adversity and stressful life events, among others. Over the past decades, studies in fields ranging from neuroanatomy, genetics and molecular psychiatry have led to a model whereby behavioural dysregulation, including suicidal behaviour (SB), develops as a function of biological adaptations in key brain systems...
July 11, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28686564/asperger-syndrome-and-schizophrenia-%C3%AE-eurodevelopmental-continuum-or-separated-clinical-entities
#17
Chr Anomitri, H Lazaratou
This article is an overview of the literature on Asperger's syndrome and schizophrenia and aim to discuss their similarities and differences. Eugen Bleuler who associated the terms "schizophrenia" and "autism" a century ago, viewed autism as a form of solitude of schizophrenic patients representing withdrawal from reality. Ever since, there has been confusion as to the boundaries between these conditions. Nowadays recent research, from a variety of perspectives-genomics, neurodevelopment, psychiatry, etc. has given new information on these conditions...
April 2017: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/28679439/minor-depression-in-older-long-term-unemployed-people-seeking-vocational-support
#18
Sabrina Pfeil, Katrin Holtz, Kathrin-Andrea Kopf, Ulrich Hegerl, Christine Rummel-Kluge
BACKGROUND: Prevalence rates of minor and major depression vary from 0.7 to 6.8 (minor) and 3.8 to 10.9 (major) for the general population. Twenty-two percent of older, long-term unemployed people suffer from major depression. However, the prevalence rate of minor depression (depression on a subthreshold level with less than 5, but more than 1 depression symptom) in this population is unknown. The first aim of this study is to identify that prevalence rate, because we already know that minor depression increases the risk of developing a major depression and this in turn reduces the chances of reemployment what increases social and individual costs at the same time...
July 5, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28678453/-suicide-and-mental-institutions-the-lausanne-example
#19
Jean-Michel Kaision, Jacques Gasser
Suicide in the mental hospital is first a human tragedy that affects the patients' families and relatives but also touches all medical staff involved. As for suicide prevention, it is a key issue of public health, and the canton of Vaud has made it a top priority of his mental health policy. We will present some epidemiologic data general of suicide and some specific elements to our institution, the Psychiatry Department of the Centre Hospitalier Universitaire Vaudois (DP-CHUV). Then we will show how our institution addresses the issue of suicide prevention through the analysis of so-called « adverse clinical events » and the systematic training of its caregivers...
September 21, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28675195/how-to-deal-with-violent-and-aggressive-patients-in-acute-medical-settings
#20
R H Harwood
Dealing with violence and aggression is an area where health professionals often feel uncertain. Standing at the interface between medicine, psychiatry and law, the best actions may not be clear, and guidelines neither consistently applicable nor explicit. An aggressive, violent or abusive patient may be behaving anti-socially or criminally. But in acute medical settings it is more likely that a medical, mental health or emotional problem, or some combination thereof, is the explanation and usually we will not know the relative contribution of each element...
June 2017: Journal of the Royal College of Physicians of Edinburgh
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