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Preventive Psychiatry

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https://www.readbyqxmd.com/read/29021832/pharmacogenomics-in-the-treatment-of-mood-disorders-strategies-and-opportunities-for-personalized-psychiatry
#1
REVIEW
Azmeraw T Amare, Klaus Oliver Schubert, Bernhard T Baune
Personalized medicine (personalized psychiatry in a specific setting) is a new model towards individualized care, in which knowledge from genomics and other omic pillars (microbiome, epigenomes, proteome, and metabolome) will be combined with clinical data to guide efforts to new drug development and targeted prescription of the existing treatment options. In this review, we summarize pharmacogenomic studies in mood disorders that may lay the foundation towards personalized psychiatry. In addition, we have discussed the possible strategies to integrate data from omic pillars as a future path to personalized psychiatry...
September 2017: EPMA Journal
https://www.readbyqxmd.com/read/29016917/cannabis-for-the-treatment-of-chronic-pain-in-the-era-of-an-opioid-epidemic-a-symposium-based-review-of-sociomedical-science
#2
Dermot P Maher, Daniel B Carr, Kevin Hill, Brian McGeeney, Valerie Weed, William C Jackson, David J DiBenedetto, Edward M Moriarty, Ronald J Kulich
Objective: This manuscript reviews medical literature published pertaining to the management of chronic pain with medical marijuana therapy (MMJ), with an emphasis on the social, medical, and legal aspects of therapy. Design: Narrative review of peer-reviewed literature. Methods: The 3rd Symposium on Controlled Substances and Their Alternatives for the Treatment of Pain was held in Boston on February 27, 2016, with a focus on MMJ for the treatment of chronic pain...
July 13, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28987051/financing-of-forensic-psychiatry-in-view-of-treatment-quality-and-threat-to-public-safety
#3
REVIEW
Janusz Heitzman, Inga Markiewicz
Stay in a psychiatric hospital of persons who committed the gravest criminal acts while in a state of insanity aims to ensure their effective treatment (therapeutic function), but above all to prevent the repetition of prohibited acts of significant harm to the community (preventive function). Forensic patients are provided with suitable medical, psychiatric, rehabilitation and resocialization care. The court imposes an indefinite detention. In view of the dual purpose of the stay in a psychiatric hospital, both therapeutic and preventive, the treatment costs generated by forensic wards are higher than those of general psychiatric wards...
August 29, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/28984077/broad-clinical-high-risk-mental-state-charms-methodology-of-a-cohort-study-validating-criteria-for-pluripotent-risk
#4
Jessica A Hartmann, Barnaby Nelson, Rachael Spooner, G Paul Amminger, Andrew Chanen, Christopher G Davey, Meredith McHugh, Aswin Ratheesh, Devi Treen, Hok Pan Yuen, Patrick D McGorry
AIM: The development of the ultra-high risk (UHR) criteria for psychosis created a new paradigm for the prevention research in psychiatry. Since (1) prevention research faces the challenge of achieving adequate statistical power when focusing on single low-incidence syndromes and (2) early clinical phenotypes are overlapping and non-specific, this study broadens the UHR state beyond psychosis as an outcome. The CHARMS (clinical high at-risk mental state) study aims to prospectively validate a set of trans-diagnostic criteria to identify help-seeking young people at risk of developing a range of serious mental illnesses...
October 5, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28983641/-suicidality-in-german-speaking-school-psychiatry-thematization-in-textbooks-from-1803-until-the-present
#5
REVIEW
M Gnoth, H Glaesmer, H Steinberg
BACKGROUND: This chronology gives an overview about continuities and changes in the perception of suicidality in German-speaking school psychiatry over the past 200+ years. QUESTIONS: This study was guided by the following questions: has suicidality been perceived as regularly being connected to certain mental illnesses? Which other possible causes have been discussed by psychiatrists from the nineteenth century to the beginning of the twenty-first century? What approaches have major psychiatrists adopted towards suicidal patients and threatened suicide? What treatment and preventive strategies have been suggested? METHODOLOGY: First, we compiled a list of the, in our view, most influential textbooks on psychiatry of German-speaking school psychiatry from 1803 until the present...
October 5, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28972577/genome-wide-association-study-across-european-and-african-american-ancestries-identifies-a-snp-in-dnmt3b-contributing-to-nicotine-dependence
#6
D B Hancock, Y Guo, G W Reginsson, N C Gaddis, S M Lutz, R Sherva, A Loukola, C C Minica, C A Markunas, Y Han, K A Young, D F Gudbjartsson, F Gu, D W McNeil, B Qaiser, C Glasheen, S Olson, M T Landi, P A F Madden, L A Farrer, J Vink, N L Saccone, M C Neale, H R Kranzler, J McKay, R J Hung, C I Amos, M L Marazita, D I Boomsma, T B Baker, J Gelernter, J Kaprio, N E Caporaso, T E Thorgeirsson, J E Hokanson, L J Bierut, K Stefansson, E O Johnson
Cigarette smoking is a leading cause of preventable mortality worldwide. Nicotine dependence, which reduces the likelihood of quitting smoking, is a heritable trait with firmly established associations with sequence variants in nicotine acetylcholine receptor genes and at other loci. To search for additional loci, we conducted a genome-wide association study (GWAS) meta-analysis of nicotine dependence, totaling 38,602 smokers (28,677 Europeans/European Americans and 9925 African Americans) across 15 studies...
October 3, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28971296/identifying-human-trafficking-victims-on-a-psychiatry-inpatient-service-a-case-series
#7
Phuong T Nguyen, Joanna Lamkin, John H Coverdale, Samuel Scott, Karen Li, Mollie R Gordon
Human trafficking is a serious and prevalent human rights violation that closely intersects with mental health. Limited empirical attention has been paid to the presentations and identification of trafficking victims in psychiatric settings. The primary goal of this paper is to describe the varied presentations of trafficking victims on an urban inpatient psychiatric unit. A literature review was conducted to identify relevant empirical articles to inform our examination of cases. Adult inpatient cases meeting criteria for known or possible human trafficking were systematically identified and illustrative cases were described...
October 2, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/28953837/emotionally-responsive-wearable-technology-and-stress-detection-for-affective-disorders
#8
Jenny Tillotson
As humans, we are born with no knowledge of odour. Our sense of smell is linked directly to the limbic system, the emotional part of our brain responsible for memory and behaviour, and therefore, our individual sense of smell is based purely on life's deep experiences and impressions. The roots of "Aromatherapy" can be traced back more than 3,500 years, to a time when essential oils were first recorded in human history for their therapeutic and medicinal properties. However, in the 21(st) century, it remains one of the most controversial complementary therapies applied in medicine because of its pseudoscience connotations and limited available data on health benefits, despite the importance of smell on human health...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28945215/influence-of-polygenic-risk-scores-on-lipid-levels-and-dyslipidemia-in-a-psychiatric-population-receiving-weight-gain-inducing-psychotropic-drugs
#9
Aurélie Delacrétaz, Patricia Lagares Santos, Nuria Saigi Morgui, Frederik Vandenberghe, Anaïs Glatard, Mehdi Gholam-Rezaee, Armin von Gunten, Philippe Conus, Chin B Eap
OBJECTIVES: Dyslipidemia represents a major health issue in psychiatry. We determined whether weighted polygenic risk scores (wPRSs) combining multiple single-nucleotide polymorphisms (SNPs) associated with lipid levels in the general population are associated with lipid levels [high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol (TC), and triglycerides] and/or dyslipidemia in patients receiving weight gain-inducing psychotropic drugs. We also determined whether genetics improve the predictive power of dyslipidemia...
September 21, 2017: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/28942748/nutritional-psychiatry-the-present-state-of-the-evidence
#10
Wolfgang Marx, Genevieve Moseley, Michael Berk, Felice Jacka
Mental illness, including depression, anxiety and bipolar disorder, accounts for a significant proportion of global disability and poses a substantial social, economic and heath burden. Treatment is presently dominated by pharmacotherapy, such as antidepressants, and psychotherapy, such as cognitive behavioural therapy; however, such treatments avert less than half of the disease burden, suggesting that additional strategies are needed to prevent and treat mental disorders. There are now consistent mechanistic, observational and interventional data to suggest diet quality may be a modifiable risk factor for mental illness...
September 25, 2017: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/28941093/staging-in-bipolar-disorder-from-theoretical-framework-to-clinical-utility
#11
Michael Berk, Robert Post, Aswin Ratheesh, Emma Gliddon, Ajeet Singh, Eduard Vieta, Andre F Carvalho, Melanie M Ashton, Lesley Berk, Susan M Cotton, Patrick D McGorry, Brisa S Fernandes, Lakshmi N Yatham, Seetal Dodd
Illness staging is widely utilized in several medical disciplines to help predict course or prognosis, and optimize treatment. Staging models in psychiatry in general, and bipolar disorder in particular, depend on the premise that psychopathology moves along a predictable path: an at-risk or latency stage, a prodrome progressing to a first clinical threshold episode, and one or more recurrences with the potential to revert or progress to late or end-stage manifestations. The utility and validity of a staging model for bipolar disorder depend on its linking to clinical outcome, treatment response and neurobiological measures...
October 2017: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/28933639/violence-prevention-community-meeting-conducted-on-your-unit
#12
Marilyn L Lanza
The Violence Prevention Community Meeting (VPCM) is to reduce violence on inpatient psychiatry units, and has been written about elsewhere. The purpose of this article is to explain how other nurses can implement a similar meeting in their work setting. Details of different aspects of the VPCM are provided including the purpose, administrative support role of patients and staff, and the content and process of the VPCM. The reader is presented with several different scenarios about assault. The VPCM is an innovative, group-based treatment, administered by nursing staff members...
October 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28918771/falls-in-hospitalized-geriatric-psychiatry-patients-high-incidence-but-only-a-few-fractures
#13
Dennis Oepen, Tim Fleiner, Andrés Oliva Y Hausmann, Susanne Zank, Wiebren Zijlstra, Peter Haeussermann
Fall rates from 3.2 to 17.1 falls per 1,000 hospital days in geriatric psychiatry facilities have been reported to date. Up to 5% of the falls result in severe injuries, but data concerning medical consequences are scare. This brief report presents a retrospective analysis of one year fall protocols from a geriatric psychiatry department focusing on consequences of falls. Fall-induced injuries were rated in four categories: no injuries, mild injuries (contusions, hematomas, abrasions), moderate injuries (lacerations, dislocations), and severe injuries (fractures, cerebral hemorrhages)...
September 18, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28915376/psychometric-properties-of-the-postpartum-bonding-questionnaire-and-correlates-of-mother-infant-bonding-impairment-in-italian-new-mothers
#14
Alessandra Busonera, Stefania Cataudella, Jessica Lampis, Marco Tommasi, Giulio Cesare Zavattini
OBJECTIVE: impaired maternal bonding is a risk factor for problems with infant well-being and development. The investigation of perinatal variables related to disorders of the mother-infant relationship as well as the administration of reliable and valid screening tools to new mothers in the postpartum can help identify early signs of a disturbed mother-child relationship. The Postpartum Bonding Questionnaire (PBQ) has been shown to be a valid screening instrument, but its dimensional structure is still controversial...
September 1, 2017: Midwifery
https://www.readbyqxmd.com/read/28894302/g%C3%AE-%C3%AE-subunit-activation-promotes-dopamine-efflux-through-the-dopamine-transporter
#15
J Garcia-Olivares, T Baust, S Harris, P Hamilton, A Galli, S G Amara, G E Torres
The dopamine transporter (DAT) is an important regulator of brain dopamine (DA) homeostasis, controlling the intensity and duration of DA signaling. DAT is the target for psychostimulants-like cocaine and amphetamine-and plays an important role in neuropsychiatric disorders, including attention-deficit hyperactivity disorder and drug addiction. Thus, a thorough understanding of the mechanisms that regulate DAT function is necessary for the development of clinical interventions to treat DA-related brain disorders...
September 12, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28894298/molecular-basis-of-dendritic-atrophy-and-activity-in-stress-susceptibility
#16
T C Francis, R Chandra, A Gaynor, P Konkalmatt, S R Metzbower, B Evans, M Engeln, T A Blanpied, M K Lobo
Molecular and cellular adaptations in nucleus accumbens (NAc) medium spiny neurons (MSNs) underlie stress-induced depression-like behavior, but the molecular substrates mediating cellular plasticity and activity in MSN subtypes in stress susceptibility are poorly understood. We find the transcription factor early growth response 3 (EGR3) is increased in D1 receptor containing MSNs of mice susceptible to social defeat stress. Genetic reduction of Egr3 levels in D1-MSNs prevented depression-like outcomes in stress susceptible mice by preventing D1-MSN dendritic atrophy, reduced frequency of excitatory input and altered in vivo activity...
September 12, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28886959/-the-psychiatric-hospital-discharge-database-rim-p-an-essential-tool-for-the-surveillance-of-hospitalization-after-a-suicide-attempt
#17
C Chan Chee, L-M Paget
BACKGROUND: Epidemiological surveillance of suicide attempts is essential for monitoring indicator trends in the evaluation of prevention actions. As part of this surveillance, analysis of data from hospitalization for suicide attempts is particularly useful. METHODS: For the first time, data from two national hospital discharge databases, the "Programme de médicalisation des systèmes d'information en médecine, chirurgie, obstétrique" (PMSI-MCO) and the " Recueil d'information médicalisé en psychiatrie" (RIM-P) have been analyzed jointly...
September 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/28886009/tau-mediated-iron-export-prevents-ferroptotic-damage-after-ischemic-stroke
#18
Q-Z Tuo, P Lei, K A Jackman, X-L Li, H Xiong, X-L Li, Z-Y Liuyang, L Roisman, S-T Zhang, S Ayton, Q Wang, P J Crouch, K Ganio, X-C Wang, L Pei, P A Adlard, Y-M Lu, R Cappai, J-Z Wang, R Liu, A I Bush
Functional failure of tau contributes to age-dependent, iron-mediated neurotoxicity, and as iron accumulates in ischemic stroke tissue, we hypothesized that tau failure may exaggerate ischemia-reperfusion-related toxicity. Indeed, unilateral, transient middle cerebral artery occlusion (MCAO) suppressed hemispheric tau and increased iron levels in young (3-month-old) mice and rats. Wild-type mice were protected by iron-targeted interventions: ceruloplasmin and amyloid precursor protein ectodomain, as well as ferroptosis inhibitors...
September 8, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28880356/-diagnostics-of-attachment-in-child-and-adolescent-psychiatry
#19
M J van Hoof
Growing concern about how the neglect and abuse of children can be tackled and prevented has led to increased interest in the parent-child relationship and the concept of attachment. It is vitally important that the diagnostics relating to attachment are accurate. One of the main problems is that up till now the parent-child relationship has not been assessed and analysed in accordance with reliable, unambiguous standards.<br/> AIM: To search the literature in order to identify the prerequisites for reliable diagnostics of attachment...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/28869705/long-acting-injectable-antipsychotics-for-prevention-and-management-of-violent-behaviour-in-psychotic-patients
#20
REVIEW
Pavel Mohr, Pavel Knytl, Veronika Voráčková, Anna Bravermanová, Tomáš Melicher
BACKGROUND AND AIMS: It has been well established that long-term antipsychotic treatment prevents relapse, lowers number of rehospitalisations, and also effectively reduces violent behaviour. Although violent behaviour is not a typical manifestation of schizophrenia or other psychotic disorders, the diagnosis of psychosis increases the overall risk of violence. One of the few modifiable factors of violence risk is adherence with medication. In contrast, non-adherence with drug treatment and subsequent relapse increases risk of violent acts...
September 4, 2017: International Journal of Clinical Practice
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