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https://www.readbyqxmd.com/read/28806759/peculiar-genes-selection-a-new-features-selection-method-to-improve-classification-performances-in-imbalanced-data-sets
#1
Federica Martina, Marco Beccuti, Gianfranco Balbo, Francesca Cordero
High-Throughput technologies provide genomic and trascriptomic data that are suitable for biomarker detection for classification purposes. However, the high dimension of the output of such technologies and the characteristics of the data sets analysed represent an issue for the classification task. Here we present a new feature selection method based on three steps to detect class-specific biomarkers in case of high-dimensional data sets. The first step detects the differentially expressed genes according to the experimental conditions tested in the experimental design, the second step filters out the features with low discriminative power and the third step detects the class-specific features and defines the final biomarker as the union of the class-specific features...
2017: PloS One
https://www.readbyqxmd.com/read/28805221/a-simplified-ab-initio-treatment-of-diradicaloid-structures-produced-from-stretching-and-breaking-chemical-bonds
#2
Suvonil Sinha Ray, Anirban Ghosh, Anindita Shit, Rajat K Chaudhuri, Sudip Chattopadhyay
The present investigation reports on the prospect of using state specific multireference perturbation theory (SSMRPT) with an improved virtual orbital complete active space configuration interaction (IVO-CASCI) reference function (IVO-SSMRPT) to generate potential energy surfaces (PESs) for molecular systems [such as CH4, C2H6, C2H4, H2O2, LiH, and KN] by stretching and breaking of suitable bonds with modest basis sets. We have also revisited the dissociation energy profile of triplet ketene which exhibits a step-like structure in the observed rate...
August 14, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28803205/water-footprint-assessment-for-crop-production-based-on-field-measurements-a-case-study-of-irrigated-paddy-rice-in-east-china
#3
Cao Xinchun, Wu Mengyang, Shu Rui, Zhuo La, Chen Dan, Shao Guangcheng, Guo Xiangping, Wang Weiguang, Tang Shuhai
Water footprint (WF) is a comprehensive measure of water consumption by human activities and can be used to assess the impact on both water volume and quality. This study aims to explore the feasibility of evaluating green, blue and grey WFs of crop production based on field measurements. The irrigated paddy rice grown in three different experimental sites in different typical irrigation districts in Huai'an, East China over 2011 to 2014 was taken as study case. With fixed irrigation and fertilization, on the basis of measuring field water and fertilizer balance at daily step, we calculated WF of crop production under different test treatments...
August 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28799201/new-experimental-reference-data-for-hexafluorinated-propanol-by-exploring-an-unusual-intermolecular-torsional-balance
#4
Sönke Oswald, Martin A Suhm
The hydrogen-bonded dimer of 1,1,1,3,3,3-hexafluoro-2-propanol forms an intermolecular -OH...O- torsional balance, in which the acceptor OH group can point away from or towards the fluorines of the donor. It prefers the former arrangement in the free dimer, but dinitrogen coordination of the acceptor OH favors the latter, as FTIR spectroscopy in supersonic jets suggests. A multi-step divide-and-conquer strategy was employed to rule out density functional and other inexpensive quantum chemical methods within the harmonic approximation...
August 11, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28799130/near-set-based-mucin-segmentation-in-histopathology-images-for-detecting-mucinous-carcinoma
#5
Soma Banerjee, Monjoy Saha, Indu Arun, Bijan Basak, Sanjit Agarwal, Rosina Ahmed, Sanjoy Chatterjee, Lipi B Mahanta, Chandan Chakraborty
This paper introducesnear-set based segmentation method for extraction and quantification of mucin regions for detecting mucinouscarcinoma (MC which is a sub type of Invasive ductal carcinoma (IDC)). From histology point of view, the presence of mucin is one of the indicators for detection of this carcinoma. In order to detect MC, the proposed method majorly includes pre-processing by colour correction, colour transformation followed by near-set based segmentation and post-processing for delineating only mucin regions from the histological images at 40×...
August 10, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28799050/environmental-building-policy-by-the-use-of-microalgae-and-decreasing-of-risks-for-canadian-oil-sand-sector-development
#6
Armen B Avagyan
Environmental building recommendations aimed towards new environmental policies and management-changing decisions which as example demonstrated in consideration of the problems of Canadian oil sands operators. For the implementation of the circular economic strategy, we use an in-depth analysis of reported environmental after-consequence on all stages of the production process. The study addressed the promotion of innovative solutions for greenhouse gas emission, waste mitigation, and risk of falling in oil prices for operators of oil sands with creating market opportunities...
August 10, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28798748/role-of-type-i-and-ii-interferons-in-colorectal-cancer-and-melanoma
#7
REVIEW
Simone Di Franco, Alice Turdo, Matilde Todaro, Giorgio Stassi
Cancer can be considered an aberrant organ with a hierarchical composition of different cell populations. The tumor microenvironment, including the immune cells and related cytokines, is crucial during all the steps of tumor development. In particular, type I and II interferons (IFNs) are involved in a plethora of mechanisms that regulate immune responses in cancer, thus balancing immune escape versus immune surveillance. IFNs are involved in both the direct and indirect regulation of cancer cell proliferation and metastatic potential...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28797619/mechanical-ventilation-weaning-protocol-improves-medical-adherence-and-results
#8
Luís Guilherme Alegretti Borges, Augusto Savi, Cassiano Teixeira, Roselaine Pinheiro de Oliveira, Marcio Luiz Ferreira De Camillis, Ricardo Wickert, Sérgio Fernando Monteiro Brodt, Túlio Frederico Tonietto, Ricardo Cremonese, Leonardo Silveira da Silva, Fernanda Gehm, Eubrando Silvestre Oliveira, Jose Herve Diel Barth, Juçara Gasparetto Macari, Cíntia Dias de Barros, Sílvia Regina Rios Vieira
INTRODUCTION: Implementation of a weaning protocol is related to better patient prognosis. However, new approaches may take several years to become the standard of care in daily practice. We conducted a prospective cohort study to investigate the effectiveness of a multifaceted strategy to implement a protocol to wean patients from mechanical ventilation (MV) and to evaluate the weaning success rate as well as practitioner adherence to the protocol. METHODS: We investigated all consecutive MV-dependent subjects admitted to a medical-surgical intensive care unit (ICU) for >24h over 7years...
July 12, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28797226/network-design-and-analysis-for-multi-enzyme-biocatalysis
#9
Lisa Katharina Blaß, Christian Weyler, Elmar Heinzle
BACKGROUND: As more and more biological reaction data become available, the full exploration of the enzymatic potential for the synthesis of valuable products opens up exciting new opportunities but is becoming increasingly complex. The manual design of multi-step biosynthesis routes involving enzymes from different organisms is very challenging. To harness the full enzymatic potential, we developed a computational tool for the directed design of biosynthetic production pathways for multi-step catalysis with in vitro enzyme cascades, cell hydrolysates and permeabilized cells...
August 10, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28795150/the-effects-of-tacrolimus-on-t-cell-proliferation-are-short-lived-a-pilot-analysis-of-immune-function-testing
#10
Benjamin L Laskin, Jing Jiao, H Jorge Baluarte, Sandra Amaral, Susan L Furth, Tatiana Akimova, Wayne W Hancock, Matthew H Levine, Peter P Reese, Ulf H Beier
BACKGROUND: Optimal immunosuppression after organ transplant should balance the risks of rejection, infection, and malignancy while minimizing barriers to adherence including frequent or time-sensitive dosing. There is currently no reliable immune function assay to directly measure the degree of immunosuppression after transplantation. METHODS: We developed an immune function assay to mea//sure T-cell proliferation after exposure to immunosuppression in vivo. We tested the assay in mice, and then piloted the approach using single time point samples, 11 pediatric kidney transplant recipients prescribed tacrolimus, mycophenolate, and prednisone 6 months to 5 years posttransplant, with no history of rejection, opportunistic infection, or cancer...
August 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28794028/the-reovirus-%C3%AE-1-340-343-loop-controls-entry-related-conformational-changes
#11
Anthony J Snyder, Pranav Danthi
Reovirus particles are covered with 200 μ1/σ3 heterohexamers. Following attachment to cell surface receptors, reovirus is internalized by receptor-mediated endocytosis. Within the endosome, particles undergo a series of step-wise disassembly events. First, the σ3 protector protein is degraded by cellular proteases to generate infectious subviral particles (ISVPs). Second, the μ1 protein rearranges into a protease sensitive conformation to generate ISVP*s and releases two virally encoded peptides, μ1N and Φ...
August 9, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28792731/catalytic-enantioselective-carbonyl-allylation-and-propargylation-via-alcohol-mediated-hydrogen-transfer-merging-the-chemistry-of-grignard-and-sabatier
#12
Seung Wook Kim, Wandi Zhang, Michael J Krische
Merging the characteristics of transfer hydrogenation and carbonyl addition, we have developed a new class of catalytic enantioselective C-C bond formations. In these processes, hydrogen transfer between alcohols and π-unsaturated reactants generates carbonyl-organometal pairs that combine to deliver products of addition. On the basis of this mechanistic paradigm, lower alcohols are converted directly to higher alcohols in the absence of premetalated reagents or discrete alcohol-to-carbonyl redox reactions...
August 9, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28791006/regulation-of-lung-epithelial-sodium-channels-by-cytokines-and-chemokines
#13
REVIEW
Brandi M Wynne, Li Zou, Valerie Linck, Robert S Hoover, He-Ping Ma, Douglas C Eaton
Acute lung injury leading to acute respiratory distress (ARDS) is a global health concern. ARDS patients have significant pulmonary inflammation leading to flooding of the pulmonary alveoli. This prevents normal gas exchange with consequent hypoxemia and causes mortality. A thin fluid layer in the alveoli is normal. The maintenance of this thin layer results from fluid movement out of the pulmonary capillaries into the alveolar interstitium driven by vascular hydrostatic pressure and then through alveolar tight junctions...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28783460/engaging-parents-in-early-head-start-home-based-programs-how-do-home-visitors-do-this
#14
Caroline Shanti
Parental engagement is considered elemental to successful outcomes for parents and their children in early childhood home visiting programs. Engagement is that piece of parental involvement that refers to the working relationship between the parent and the home visitor. Multiple papers have called for research to pinpoint the ways in which home visitors work with parents to form these working relationships, and form partnerships to achieve positive outcomes. Analysis revealed that in individualizing their efforts to each family, home visitors follow semi-sequential steps in implementing engagement...
August 7, 2017: Journal of Evidence-informed Social Work
https://www.readbyqxmd.com/read/28783022/environmental-life-cycle-assessment-on-the-separation-of-rare-earth-oxides-through-solvent-extraction
#15
Ehsan Vahidi, Fu Zhao
Over the past decade, Rare Earth Elements (REEs) have gained special interests due to their significance in many industrial applications, especially those related to clean energy. While REEs production is known to cause damage to the ecosystem, only a handful of Life Cycle Assessment (LCA) investigations have been conducted in recent years, mainly due to lack of data and information. This is especially true for the solvent extraction separation of REEs from aqueous solution which is a challenging step in the REEs production route...
August 4, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28774585/municipal-solid-waste-incineration-plant-a-multi-step-approach-to-the-evaluation-of-an-energy-recovery-configuration
#16
D Panepinto, M C Zanetti
This study proposes a multi-step approach to evaluating the environmental and economic aspects of a thermal treatment plant with an energy-recovery configuration. In order to validate the proposed approach, the Turin incineration plant was analyzed, and the potential of the incinerator and several different possible connections to the district heating network were then considered. Both local and global environmental balances were defined. The global-scale results provided information on carbon dioxide emissions, while the local-scale results were used as reference values for the implementation of a Gaussian model that could evaluate the actual concentrations of pollutants released into the atmosphere...
July 31, 2017: Waste Management
https://www.readbyqxmd.com/read/28774417/treatment-of-hepatitis-b-virus-with-combination-therapy-now-and-in-the-future
#17
REVIEW
Joel S Emery, Jordan J Feld
Chronic Hepatitis B continues as a significant public health problem despite the availability of safe and effective antivirals and a highly effective protective vaccine. Current therapy, however rarely leads to cure and lifelong therapy is often required, contributing to poor uptake and ongoing morbidity. New insights into the hepatitis B viral life cycle and the host immune response have expanded the potential targets for drug therapies with interesting antiviral candidates and novel immunotherapeutic approaches in early stage development...
June 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/28772077/efficient-electrosteric-assembly-of-nanoparticle-heterodimers-and-linear-heteroassemblies
#18
Ryan Kastilani, Ryan Wong, Lilo D Pozzo
Bottom-up approaches to the synthesis of nanostructures are of particular interest because they offer several advantages over the traditional top-down approaches. In this work, we present a new method to self-assemble nanoparticles into controlled heteroaggregates. The technique relies on carefully balancing attractive electrostatic forces with repulsive steric hindrance that is provided by surface-grafted polyethylene glycol (PEG). Two different-sized gold nanoparticles (GNP) were used as a model system; 13 nm GNPs were functionalized with PEG-thiol and dodecanoic thiol, while 7 nm GNPs were functionalized with PEG-thiol and (11- Mercaptoundecyl)trimethylammonium bromide...
August 3, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28771062/predicting-falls-in-older-adults-using-the-four-square-step-test
#19
Kimberly Cleary, Elena Skornyakov
The Four Square Step Test (FSST) is a performance-based balance tool involving stepping over four single-point canes placed on the floor in a cross configuration. The purpose of this study was to evaluate properties of the FSST in older adults who lived independently. Forty-five community dwelling older adults provided fall history and completed the FSST, Berg Balance Scale (BBS), Timed Up and Go (TUG), and Tinetti in random order. Future falls were recorded for 12 months following testing. The FSST accurately distinguished between non-fallers and multiple fallers, and the 15-second threshold score accurately distinguished multiple fallers from non-multiple fallers based on fall history...
August 3, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28769972/the-first-molecular-identification-of-an-olive-collection-applying-standard-simple-sequence-repeats-and-novel-expressed-sequence-tag-markers
#20
Soraya Mousavi, Roberto Mariotti, Luca Regni, Luigi Nasini, Marina Bufacchi, Saverio Pandolfi, Luciana Baldoni, Primo Proietti
Germplasm collections of tree crop species represent fundamental tools for conservation of diversity and key steps for its characterization and evaluation. For the olive tree, several collections were created all over the world, but only few of them have been fully characterized and molecularly identified. The olive collection of Perugia University (UNIPG), established in the years' 60, represents one of the first attempts to gather and safeguard olive diversity, keeping together cultivars from different countries...
2017: Frontiers in Plant Science
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