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https://www.readbyqxmd.com/read/28542281/gait-asymmetry-ankle-spasticity-and-depression-as-independent-predictors-of-falls-in-ambulatory-stroke-patients
#1
Ta-Sen Wei, Peng-Ta Liu, Liang-Wey Chang, Sen-Yung Liu
BACKGROUND: Falls are the leading cause of injury in stroke patients. However, the cause of a fall is complicated, and several types of risk factors are involved. Therefore, a comprehensive model to predict falls with high sensitivity and specificity is needed. METHODS: This study was a prospective study of 112 inpatients in a rehabilitation ward with follow-up interviews in patients' homes. Evaluations were performed 1 month after stroke and included the following factors: (1) status of cognition, depression, fear of fall and limb spasticity; (2) functional assessments [walking velocity and the Functional Independence Measure (FIM)]; and (3) objective, computerized gait and balance analyses...
2017: PloS One
https://www.readbyqxmd.com/read/28542187/elucidation-of-new-condition-dependent-roles-for-fructose-1-6-bisphosphatase-linked-to-cofactor-balances
#2
Du Toit W P Schabort, Stephanus G Kilian, James C du Preez
The cofactor balances in metabolism is of paramount importance in the design of a metabolic engineering strategy and understanding the regulation of metabolism in general. ATP, NAD+ and NADP+ balances are central players linking the various fluxes in central metabolism as well as biomass formation. NADP+ is especially important in the metabolic engineering of yeasts for xylose fermentation, since NADPH is required by most yeasts in the initial step of xylose utilisation, including the fast-growing Kluyveromyces marxianus...
2017: PloS One
https://www.readbyqxmd.com/read/28542090/5-km-time-trial-reliability-of-a-non-motorized-treadmill-and-comparison-of-physiological-and-perceptual-responses-versus-a-motorized-treadmill
#3
Hunter S Waldman, Alex J Heatherly, Ashton F Waddell, Ben M Krings, Eric K O'Neal
This study examined the reproducibility of performance across 3 non-motorized treadmill (NMT) 5-km time trials (TT) and physiological, gait, and perceptual differences of running at 5-km pace for both NMT and motorized treadmills (MT). Ten male runners experienced in road racing that had never run on a NMT completed 3 TT to establish personal best 5-km pace. In a later session, participants ran at this pace for 5 min on the NMT while metabolic, gait, and perceptual measures were recorded and then ran at outdoor 5-km personal best pace on a MT at 1% grade (counter-balanced crossover design)...
May 24, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538303/examining-fundamental-movement-competency-and-closed-chain-upper-extremity-dynamic-balance-in-swimmers
#4
Garrett S Bullock, Nate Brookreson, Amy M Knab, Robert J Butler
Bullock, GS, Brookreson, N, Knab, AM, and Butler, RJ. Examining fundamental movement competency and closed-chain upper-extremity dynamic balance in swimmers. J Strength Cond Res 31(6): 1544-1551, 2017-Abnormal fundamental movement patterns and upper-quarter dynamic balance are proposed mechanisms affecting athletic performance and injury risk. There are few studies investigating functional movement and closed-chain upper-extremity dynamic stability in swimmers. The purpose of this study was to determine differences in fundamental movement competency and closed-chain upper-extremity dynamic balance, using the Functional Movement Screen (FMS) and Upper-Quarter Y Balance Test (YBT-UQ), of high school (HS; n = 70) and collegiate (COL; n = 70) swimmers...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28537430/multifaceted-roles-of-glutathione-and-glutathione-based-systems-in-carcinogenesis-and-anticancer-drug-resistance
#5
Elie Hatem, Nadine El Banna, Meng-Er Huang
SIGNIFICANCE: Glutathione is the most abundant antioxidant molecule in living organisms and has multiple functions. Intracellular glutathione homeostasis, through its synthesis, consumption, and degradation is an intricately balanced process. Glutathione levels are often high in tumor cells prior to treatment and there is a strong correlation between elevated levels of intracellular glutathione/sustained glutathione-mediated redox activity and resistance to pro-oxidant anticancer therapy...
May 24, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28537234/-car-t-cell-therapy-balance-of-efficacy-and-safety
#6
S V Kulemzin, V V Kuznetsova, M Mamonkin, A V Taranin, A A Gorchakov
Early results from clinical trials of autologous chimeric antigen receptor (CAR)-expressing T cells for the therapy of B-cell malignancies have encouraged extending the potency of this therapy to other cancers. However, the success of using CAR T-cells to treat patients with solid tumors has been limited. In this review, we summarize current knowledge on the design and applications of CARs for the targeted therapy of cancer. We describe existing issues that limit the widespread application of CAR T cells and discuss the optimization steps needed to further improve safety and efficacy of this therapeutic platform...
March 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/28532942/robot-assisted-simulated-cataract-surgery
#7
Tristan Bourcier, Jimmy Chammas, Pierre-Henri Becmeur, Arnaud Sauer, David Gaucher, Philippe Liverneaux, Jacques Marescaux, Didier Mutter
PURPOSE: To evaluate the feasibility of robot-assisted simulated cataract surgery. SETTING: Institut de Recherche Contre les Cancers de l'Appareil Digestif, European Institute of Telesurgery, and Strasbourg University Hospital, Strasbourg, France. DESIGN: Experimental study. METHODS: Cataract surgeries were performed on a Kitaro cataract wet-lab training system simultaneously using the Da Vinci Xi robotic surgical system and the Whitestar Signature phacoemulsification system...
April 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28530519/does-a-one-size-fits-all-cost-sharing-approach-incentivize-appropriate-medication-use-a-roundtable-on-the-fairness-and-ethics-associated-with-variable-cost-sharing
#8
Jennifer S Graff, Chuck Shih, Thomas Barker, Gabriela Dieguez, Cheryl Larson, Helen Sherman, Robert W Dubois
BACKGROUND: Tiered formularies, in which patients pay copays or coinsurance out-of-pocket (OOP), are used to manage costs and encourage more efficient health care resource use. Formulary tiers are typically based on the cost of treatment rather than the medical appropriateness for the patient. Cost sharing may have unintended consequences on treatment adherence and health outcomes. Use of higher-cost, higher-tier medications can be due to a variety of factors, including unsuccessful treatment because of lack of efficacy or side effects, patient clinical or genetic characteristics, patient preferences to avoid potential side effects, or patient preferences based on the route of administration...
June 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28530008/field-strength-and-frequency-tunable-two-way-rotation-of-liquid-crystal-micro-particles-dispersed-in-a-liquid-crystal-host
#9
Koki Imamura, Hiroyuki Yoshida, Masanori Ozaki
Liquid crystal (LC) micro-particles are functional materials possessing anisotropies of LCs originating from their inner molecular alignment, and are fabricated by polymerizing pre-aligned rod-like molecules in the LC state. Here we demonstrate field strength and frequency tunable two-way rotation control of LC micro-particles in a LC host, and unravel its mechanism by theoretically calculating the contributing free energies. Cuboid-shaped micro-particles with inner molecular alignment along the long axis are fabricated via two-photon excited direct laser writing, and dispersed in a dual-frequency (DF) LC to be electrically driven by a voltage applied in the in-plane direction of the cell...
May 22, 2017: Soft Matter
https://www.readbyqxmd.com/read/28528238/effects-of-grab-bar-on-utilized-friction-and-dynamic-stability-when-elderly-people-enter-the-bathtub
#10
Yusuke Sekiguchi, Tomohisa Kato, Keita Honda, Hiroyasu Kanetaka, Shin-Ichi Izumi
BACKGROUND: The effect of the grab bar on dynamic stability when elderly people enter the bathtub remains unclear. The purpose of the present study is to examine the age-related effect of the grab bar on dynamic stability during lateral stepping over an obstacle when entering bathtub. METHODS: Sixteen young, healthy adults and sixteen elderly adults participated. The subjects performed lateral stepping over an obstacle with and without vertical and horizontal bars...
May 10, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28527802/abrupt-weaning-reduces-postweaning-growth-and-is-associated-with-alterations-in-gastrointestinal-markers-of-development-in-dairy-calves-fed-an-elevated-plane-of-nutrition-during-the-preweaning-period
#11
M A Steele, J H Doelman, L N Leal, F Soberon, M Carson, J A Metcalf
The benefits of feeding elevated quantities of milk to dairy calves have been well established. However, there is a reluctance to adopt this method of feeding in commercial dairy production because of concerns around growth, health, and ruminal development during weaning. The objective of this study was to characterize the effect of an abrupt (0 d step-down) or gradual (12 d step-down) feeding scheme when calves are fed an elevated plane of nutrition (offered 1.35 kg of milk replacer/d). For this experiment, a total of 54 calves were randomly assigned to an abrupt or a gradual weaning protocol before weaning at 48 d of life...
May 17, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28526585/impaired-response-selection-during-stepping-predicts-falls-in-older-people-a-cohort-study
#12
Daniel Schoene, Kim Delbaere, Stephen R Lord
BACKGROUND: Response inhibition, an important executive function, has been identified as a risk factor for falls in older people. This study investigated whether step tests that include different levels of response inhibition differ in their ability to predict falls and whether such associations are mediated by measures of attention, speed, and/or balance. METHODS: A cohort study with a 12-month follow-up was conducted in community-dwelling older people without major cognitive and mobility impairments...
May 16, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28524033/-procedural-analysis-of-acid-base-balance-disorder-case-serials-in-4-patents
#13
Chunyuan Ma, Guijie Wang
OBJECTIVE: To establish the standardization process of acid-base balance analysis, analyze cases of acid-base balance disorder with the aid of acid-base balance coordinate graph. METHODS: The acid-base balance theory were reviewed systematically on recent research progress, and the important concepts, definitions, formulas, parameters, regularity and inference in the analysis of acid-base balance were studied. The analysis of acid-base balance disordered processes and steps were figured...
May 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28521148/dual-task-interference-on-postural-sway-postural-transitions-and-gait-in-people-with-parkinson-s-disease-and-freezing-of-gait
#14
Ana Claudia de Souza Fortaleza, Martina Mancini, Patty Carlson-Kuhta, Laurie A King, John G Nutt, Eliane Ferrari Chagas, Ismael Forte Freitas, Fay B Horak
Freezing of gait (FoG) is associated with less automatic gait and more impaired cognition, balance and postural transitions compared to people with PD who do not have FoG. However, it is unknown whether dual-task cost during postural sway, postural transitions (such as gait initiation and turning), and gait are more in subjects with Parkinson's disease (PD) who have freezing of gait (FoG+) compared to those who do not have FoG (FoG-). Here, we hypothesized that the effects of a cognitive dual task on postural sway, postural transitions and gait would be larger in FoG+ than FoG-...
May 10, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28520598/imaging-plus-x-multimodal-models-of-neurodegenerative-disease
#15
Neil P Oxtoby, Daniel C Alexander
PURPOSE OF REVIEW: This article argues that the time is approaching for data-driven disease modelling to take centre stage in the study and management of neurodegenerative disease. The snowstorm of data now available to the clinician defies qualitative evaluation; the heterogeneity of data types complicates integration through traditional statistical methods; and the large datasets becoming available remain far from the big-data sizes necessary for fully data-driven machine-learning approaches...
May 16, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28520181/encapsulation-and-polymerization-of-white-phosphorus-inside-single-wall-carbon-nanotubes
#16
Martin Hart, Edward R White, Ji Chen, Catriona M McGilvery, Chris J Pickard, Angelos Michaelides, Andrea Sella, Milo Shaffer, Christoph G√ľnter Salzmann
Elemental phosphorus displays an impressive number of allotropes with highly diverse chemical and physical properties. Here, we report that white phosphorus can be filled into single-wall carbon nanotubes (SWCNTs) from the liquid and thereby stabilized against the highly exothermic reaction with atmospheric oxygen. The encapsulated tetraphosphorus molecules were visualized with transmission electron microscopy, but found to convert readily to chain structures inside the SWCNT 'nanoreactors'. The energies of the possible chain structures were determined computationally highlighting a delicate balance between the extent of polymerization and the SWCNT diameter...
May 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28516993/stable-and-conductive-lead-halide-perovskites-facilitated-by-x-type-ligands
#17
Longfei Ruan, Wei Shen, Aifei Wang, Qingwen Zhou, Huigang Zhang, Zhengtao Deng
Lead halide perovskites exhibit outstanding optoelectronic and optical properties. However, some applications of perovskites are hindered by their instability in polar environments; thus, how to balance stability with conductivity is a great challenge. Here, we report a new approach of using X-type ligands to address this issue. Surface treatments containing multi-step ligand exchanges and ion filling were necessary to obtain X-type ligand-protected perovskites. Performances of this material show that: (1) the crystal structure of perovskites is stable in ethanol; (2) surface defects can be fixed by a photoactivation process and photoluminescence intensity can be enhanced to 136%; and (3) electronic devices fabricated from such materials show stabilility even after washing with ethanol...
May 18, 2017: Nanoscale
https://www.readbyqxmd.com/read/28515799/implementing-mindfulness-in-the-mainstream-making-the-path-by-walking-it
#18
Rebecca S Crane
There is expanding interest in mindfulness-based programs (MBPs) within the mainstream. While there are research gaps, there is empirical evidence for these developments. Implementing new evidence into practice is always complex and difficult. Particular complexities and tensions arise when implementing MBPs in the mainstream. MBPs are emerging out of the confluence of different epistemologies-contemplative teaching and practice, and contemporary Western empiricism and culture. In the process of navigating implementation and integrity, and developing a professional practice context for this emerging field, the diverse influences within this confluence need careful attention and thought...
2017: Mindfulness
https://www.readbyqxmd.com/read/28515696/the-reliability-and-validity-of-a-four-minute-running-time-trial-in-assessing-formula-see-text-max-and-performance
#19
Kerry McGawley
Introduction: Traditional graded-exercise tests to volitional exhaustion (GXTs) are limited by the need to establish starting workloads, stage durations, and step increments. Short-duration time-trials (TTs) may be easier to implement and more ecologically valid in terms of real-world athletic events. The purpose of the current study was to assess the reliability and validity of maximal oxygen uptake ([Formula: see text]max) and performance measured during a traditional GXT (STEP) and a four-minute running time-trial (RunTT)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28515555/quantitative-balance-and-gait-measurement-in-patients-with-frontotemporal-dementia-and-alzheimer-diseases-a-pilot-study
#20
Selva Ganapathy Velayutham, Sadanandavalli Retnaswami Chandra, Srikala Bharath, Ravi Girikamatha Shankar
INTRODUCTION: Alzhiemers disease and Frontotemporal dementia are common neurodegenerative dementias with a wide prevalence. Falls are a common cause of morbidity in these patients. Identifying subclinical involvement of these parameters might serve as a tool in differential analysis of these distinct parameters involved in these conditions and also help in planning preventive strategies to prevent falls. PATIENTS AND METHODS: Eight patients in age and gender matched patients in each group were compared with normal controls...
March 2017: Indian Journal of Psychological Medicine
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