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https://www.readbyqxmd.com/read/28935262/identification-of-the-period-of-stability-in-a-balance-test-after-stepping-up-using-a-simplified-cumulative-sum
#1
Doha Safieddine, Aly Chkeir, Cyrille Herlem, Delphine Bera, Michèle Collart, Jean-Luc Novella, Moustapha Dramé, David J Hewson, Jacques Duchêne
Falls are a major cause of death in older people. One method used to predict falls is analysis of Centre of Pressure (CoP) displacement, which provides a measure of balance quality. The Balance Quality Tester (BQT) is a device based on a commercial bathroom scale that calculates instantaneous values of vertical ground reaction force (Fz) as well as the CoP in both anteroposterior (AP) and mediolateral (ML) directions. The entire testing process needs to take no longer than 12 s to ensure subject compliance, making it vital that calculations related to balance are only calculated for the period when the subject is static...
September 18, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28934978/adaptation-of-the-2015-american-college-of-rheumatology-treatment-guideline-for-rheumatoid-arthritis-for-the-eastern-mediterranean-region-an-exemplar-of-the-grade-adolopment
#2
Andrea Darzi, Manale Harfouche, Thurayya Arayssi, Samar Alemadi, Khaled A Alnaqbi, Humeira Badsha, Farida Al Balushi, Bassel Elzorkany, Hussein Halabi, Mohammed Hamoudeh, Wissam Hazer, Basel Masri, Mohammed A Omair, Imad Uthman, Nelly Ziade, Jasvinder A Singh, Robin Christiansen, Peter Tugwell, Holger J Schünemann, Elie A Akl
BACKGROUND: It has been hypothesized that adaptation of health practice guidelines to the local setting is expected to improve their uptake and implementation while cutting on required resources. We recently adapted the published American College of Rheumatology (ACR) Rheumatoid Arthritis (RA) treatment guideline to the Eastern Mediterranean Region (EMR). The objective of this paper is to describe the process used for the adaptation of the 2015 ACR guideline on the treatment of RA for the EMR...
September 21, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28933362/male-infertility-the-effect-of-natural-antioxidants-and-phytocompounds-on-seminal-oxidative-stress
#3
REVIEW
Malik Adewoyin, Muhammad Ibrahim, Ramli Roszaman, Muhammad Lokman Md Isa, Nur Aizura Mat Alewi, Ainin Azwani Abdul Rafa, Mohd Nur Nasyriq Anuar
Defective sperm function has been identified as the most common cause of infertility. The objective of this study was to review recent findings on the effects of various antioxidants on male fertility. High amounts of poly unsaturated fatty acid are found in the mammalian spermatozoa membranes, thereby making them susceptible to lipid peroxidation. Although, free radicals and reactive oxygen species (ROS) play major roles in reproduction, they are strongly associated with oxidative stress. Furthermore, factors such as obesity, inflammation, pollutants and cigarette smoking are negatively correlated with spermatogenesis...
March 1, 2017: Diseases (Basel)
https://www.readbyqxmd.com/read/28930598/enzymatically-modified-ldl-atherosclerosis-and-beyond-paving-the-way-to-acceptance
#4
Michael Torzewski
The eLDL (enzymatically modified LDL) hypothesis proposes that modification of LDL during atherogenesis occurs through the action of ubiquitous hydrolytic enzymes. eLDL is recognized by multiple macrophage receptors. Following cellular uptake, eLDL triggers atherosclerotic lesion initiation with reversion or progression depending on the balance between cholesterol insudation and depletion. The effects of eLDL on cellular constituents of the atherosclerotic lesion comprise both pro- and anti-inflammatory mechanisms...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28929193/immune-regulation-by-ubiquitin-tagging-as-checkpoint-code
#5
Peng Zeng, Jieyu Ma, Runqing Yang, Yun-Cai Liu
The immune system is equipped with effective machinery to mobilize its activation to defend invading microorganisms, and at the same time, to refrain from attacking its own tissues to maintain immune tolerance. The balance of activation and tolerance is tightly controlled by diverse mechanisms, since breakdown of tolerance could result in disastrous consequences such as the development of autoimmune diseases. One of the mechanisms is by the means of protein ubiquitination, which involves the process of tagging a small peptide ubiquitin to protein substrates...
September 20, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28928432/two-nad-linked-redox-shuttles-maintain-the-peroxisomal-redox-balance-in-saccharomyces-cerevisiae
#6
Nadal A Al-Saryi, Murtakab Y Al-Hejjaj, Carlo W T van Roermund, Georgia E Hulmes, Lakhan Ekal, Chantell Payton, Ronald J A Wanders, Ewald H Hettema
In Saccharomyces cerevisiae, peroxisomes are the sole site of fatty acid β-oxidation. During this process, NAD(+) is reduced to NADH. When cells are grown on oleate medium, peroxisomal NADH is reoxidised to NAD(+) by malate dehydrogenase (Mdh3p) and reduction equivalents are transferred to the cytosol by the malate/oxaloacetate shuttle. The ultimate step in lysine biosynthesis, the NAD(+)-dependent dehydrogenation of saccharopine to lysine, is another NAD(+)-dependent reaction performed inside peroxisomes...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28922313/lateral-perturbation-induced-stepping-strategies-and-predictors-in-persons-poststroke
#7
Vicki L Gray, Chieh-Ling Yang, Sandy McCombe Waller, Mark W Rogers
BACKGROUND AND PURPOSE: Falls commonly occur as weight is transferred laterally, and impaired reactive stepping responses are associated with falls after stroke. The purpose of this study was to examine differences in and the determinants of mediolateral (M-L) protective stepping strategies when pulled off balance toward the paretic and nonparetic sides. METHODS: Eighteen individuals more than 6 months poststroke were pulled in the M-L direction by a lateral waist-pull perturbation system...
October 2017: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/28922312/maximum-step-length-test-performance-in-people-with-parkinson-disease-a-cross-sectional-study
#8
Ryan P Duncan, Marie E McNeely, Gammon M Earhart
BACKGROUND AND PURPOSE: The Maximum Step Length Test (MSLT), a measure of one's capacity to produce a large step, has been studied in older adults, but not in people with Parkinson disease (PD). We characterized performance and construct validity of the MSLT in PD. METHODS: Forty participants (mean age: 65.12 ± 8.20 years; 45% female) with idiopathic PD completed the MSLT while "OFF" and "ON" anti-PD medication. Construct validity was investigated by examining relationships between MSLT and measures of motor performance...
October 2017: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/28921660/rapid-whole-brain-gray-matter-imaging-using-single-slab-three-dimensional-dual-echo-fast-spin-echo-a-feasibility-study
#9
Hyunyeol Lee, Eung Yeop Kim, Chul-Ho Sohn, Jaeseok Park
PURPOSE: To achieve rapid, high resolution whole-brain gray matter (GM) imaging by developing a novel, single-slab three-dimensional dual-echo fast-spin-echo pulse sequence and GM-selective reconstruction. METHODS: Unlike conventional GM imaging that uses time-consuming double-inversion-recovery preparation, the proposed pulse sequence was designed to have two split portions along the echo train, in which the first half was dedicated to yield short inversion recovery (IR)-induced white matter suppression and variable-flip-angle-induced two-step GM signal evolution while the second half cerebrospinal fluid-only signals...
September 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28921556/dating-and-sexual-violence-research-in-the-schools-balancing-protection-of-confidentiality-with-supporting-the-welfare-of-survivors
#10
Jill D Sharkey, Lauren A Reed, Erika D Felix
Rigorous research and program evaluation are needed to understand the experience of dating and sexual violence among youth and the impact of prevention and intervention efforts. Our dilemma in doing this work occurred when youth disclosed dating and sexual violence on a research survey. What responsibility do researchers have to protect survivors' confidentiality as a research participant versus taking steps to ensure the student has the opportunity to access help? In our evaluation of a pilot dating violence prevention program, our protocols employed widely used procedures for providing resources to participants upon their completion of the survey and de-identifying survey data...
September 18, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/28921510/development-of-a-formaldehyde-biosensor-with-application-to-synthetic-methylotrophy
#11
Benjamin M Woolston, Timothy Roth, Ishwar Kohale, David Liu, Gregory Stephanopoulos
Formaldehyde is a prevalent environmental toxin and a key intermediate in single carbon metabolism. The ability to monitor formaldehyde concentration is therefore of interest for both environmental monitoring and for metabolic engineering of native and synthetic methylotrophs, but current methods suffer from low sensitivity, complex workflows, or require expensive analytical equipment. Here we develop a formaldehyde biosensor based on the FrmR repressor protein and cognate promoter of E. coli. Optimization of the native repressor binding site and regulatory architecture enabled detection at levels as low as 1 µM...
September 16, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28918597/effect-of-vibration-on-postural-control-and-gait-of-elderly-subjects-a-systematic-review
#12
REVIEW
Atefeh Aboutorabi, Mokhtar Arazpour, Mahmood Bahramizadeh, Farzam Farahmand, Reza Fadayevatan
BACKGROUND AND AIM: Gait and balance disorders are common in the elderly populations, and their prevalence increases with age. This systematic review was performed to summarize the current evidence for subthreshold vibration interventions on postural control and gait in elderly. METHOD: A review of intervention studies including the following words in the title/abstract: insole, foot and ankle appliances, vibration, noise and elderly related to balance and gait...
September 16, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28916744/hydrogen-sulphate-based-ionic-liquid-assisted-electro-polymerization-of-pedot-catalyst-material-for-high-efficiency-photoelectrochemical-solar-cells
#13
Buket Bezgin Carbas, Mahir Gulen, Merve Celik Tolu, Savas Sonmezoglu
This work reports the facile, one-step electro-polymerization synthesis of poly (3,4-ethylenedioxythiophene) (PEDOT) using a 1-ethyl-3-methylimidazolium hydrogen sulphate (EMIMHSO4) ionic liquid (IL) and, for the first time its utilization as a counter electrode (CE) in dye-sensitized solar cells (DSSCs). Using the IL doped PEDOT as CE, we effectively improve the solar cell efficiency to as high as 8.52%, the highest efficiency reported in 150 mC/cm(2) charge capacity, an improvement of ~52% over the control device using the bare PEDOT CE (5...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28916453/making-the-legal-and-ethical-case-for-universal-screening-for-postpartum-mood-and-anxiety-disorders-in-pediatric-primary-care
#14
Amy Lewis Gilbert, Casey Balio, Nerissa S Bauer
Postpartum depression (PPD), part of a larger spectrum of perinatal mood and anxiety disorders, affects up to 15% of women following the birth of an infant. Fathers may also be affected. PPD not only affects caregivers, but also impacts infants through mechanisms such as inadequate caregiver-infant interactions and non-adherence to safety practices. The negative impact on infants may extend across the life course through adulthood. This article seeks to move the needle toward universal screening for PPD using validated tools in pediatric primary care settings for new caregivers by making the legal and ethical case for this course of action in a manner that is both compelling and accessible for clinicians...
September 12, 2017: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/28914722/factors-associated-with-pediatric-ventilator-associated-conditions-in-six-u-s-hospitals-a-nested-case-control-study
#15
Noelle M Cocoros, Gregory Priebe, James E Gray, Philip Toltzis, Gitte Y Larsen, Latania K Logan, Susan Coffin, Julia S Sammons, Kathleen Deakins, Kelly Horan, Matthew Lakoma, Jessica Young, Michael Burton, Michael Klompas, Grace M Lee
OBJECTIVES: A newly proposed surveillance definition for ventilator-associated conditions among neonatal and pediatric patients has been associated with increased morbidity and mortality among ventilated patients in cardiac ICU, neonatal ICU, and PICU. This study aimed to identify potential risk factors associated with pediatric ventilator-associated conditions. DESIGN: Retrospective cohort. SETTING: Six U.S. hospitals PATIENTS:: Children less than or equal to 18 years old ventilated for greater than or equal to 1 day...
September 13, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28912534/multisegmented-nanowires-a-step-towards-the-control-of-the-domain-wall-configuration
#16
E Berganza, M Jaafar, C Bran, J A Fernández-Roldán, O Chubykalo-Fesenko, M Vázquez, A Asenjo
Cylindrical nanowires synthesized by controlled electrodeposition constitute excellent strategic candidates to engineer magnetic domain configurations. In this work, multisegmented CoNi/Ni nanowires are synthesized for tailoring a periodic magnetic structure determined by the balance between magnetocrystalline and magnetostatic energies. High-resolution Transmission Electron Microscopy confirms the segmented growth and the sharp transition between layers. Although both CoNi and Ni segments have similar fcc cubic crystal symmetry, their magnetic configuration is quite different as experimentally revealed by Magnetic Force Microscopy (MFM) imaging...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28900569/there-are-no-biomechanical-differences-between-runners-classified-by-the-functional-movement-screen
#17
Rodrigo Ribeiro de Oliveira, Shalimá Figueirêdo Chaves, Yuri Lopes Lima, Márcio Almeida Bezerra, Gabriel Peixoto Leão Almeida, Pedro Olavo de Paula Lima
BACKGROUND: Running has been one of the main choices of physical activity in people seeking an active lifestyle. The Functional Movement Screen (FMS™) is a screening tool that aims to discern movement competency. PURPOSE: The purposes of this study were to compare biomechanical characteristics between two groups rated using the composite FMS™ score, and to analyze the influence of specific individual tests. The hypothesis was that the group that scored above 14 would demonstrate better performance on biomechanical tests than the group that scored below 14...
August 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28899406/forecasting-the-regional-distribution-and-sufficiency-of-physicians-in-japan-with-a-coupled-system-dynamics-geographic-information-system-model
#18
Tomoki Ishikawa, Kensuke Fujiwara, Hisateru Ohba, Teppei Suzuki, Katsuhiko Ogasawara
BACKGROUND: In Japan, the shortage of physicians has been recognized as a major medical issue. In our previous study, we reported that the absolute shortage will be resolved in the long term, but maldistribution among specialties will persist. To address regional shortage, several Japanese medical schools increased existing quota and established "regional quotas." This study aims to assist policy makers in designing effective policies; we built a model for forecasting physician numbers by region to evaluate future physician supply-demand balances...
September 12, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28898822/enhanced-enzymatic-hydrolysis-of-eucalyptus-by-synergy-of-zinc-chloride-hydrate-pretreatment-and-bovine-serum-albumin
#19
Weiqi Wei, Shubin Wu
Enhancement of eucalyptus enzymatic saccharification by synergy of ZnCl2 hydrate pretreatment and bovine serum albumin (BSA) was investigated in this study. The result showed that the ZnCl2 hydrate pretreatment could not only selectively extract up to ∼100% of the hemicellulose from eucalyptus, but also convert portion of high crystalline cellulose I into low crystalline cellulose II, which both beneficial for enhancing subsequent pretreated solids enzymatic saccharification. The addition of BSA into enzymatic hydrolysis step could significantly promote the glucose release from pretreated solids, especially, under the low enzyme loading...
August 24, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28898168/practice-evaluation-strategies-among-social-workers-why-an-evidence-informed-dual-process-theory-still-matters
#20
Thomas D Davis
Practice evaluation strategies range in style from the formal-analytic tools of single-subject designs, rapid assessment instruments, algorithmic steps in evidence-informed practice, and computer software applications, to the informal-interactive tools of clinical supervision, consultation with colleagues, use of client feedback, and clinical experience. The purpose of this article is to provide practice researchers in social work with an evidence-informed theory that is capable of explaining both how and why social workers use practice evaluation strategies to self-monitor the effectiveness of their interventions in terms of client change...
September 12, 2017: Journal of Evidence-informed Social Work
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