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https://www.readbyqxmd.com/read/29332761/exercise-on-balance-and-function-for-knee-osteoarthritis-a%C3%A2-randomized-controlled-trial
#1
Roberta de Matos Brunelli Braghin, Elisa Cavalheiro Libardi, Carina Junqueira, Marcello Henrique Nogueira-Barbosa, Daniela Cristina Carvalho de Abreu
OBJECTIVES: To assess balance and function of symptomatic and asymptomatic subjects with knee osteoarthritis (OA) and investigate the influence of physical exercise. DESIGN: Subjects were divided into three groups: Group 1 (n = 15), symptomatic knee OA; Group 2 (n = 11), asymptomatic knee OA; and Group 3 (n = 16), knee OA and no intervention. History of falls, the WOMAC questionnaire, balance and functionality were assessed. RESULTS: After intervention, there was a significant difference in the total WOMAC score and in the pain and function domains only in Group 1...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29332757/activation-of-lower-limb-muscles-with-different-types-of-mount-in-hippotherapy
#2
Mariane Fernandes Ribeiro, Ana Paula Espindula, Domingos Emanuel Bevilacqua Júnior, Jéssica Aparecida Tolentino, Carolina Fioroni Ribeiro da Silva, Márcia Fernandes Araújo, Alex Abadio Ferreira, Vicente de Paula Antunes Teixeira
OBJECTIVES: To analyze muscle activation of lower limbs (LL) of subjects in hippotherapy sessions. METHODS: The study included 10 healthy subjects, five male and five female, with an average age of 24.03 (±4.06) years. Subjects underwent four hippotherapy sessions of 30 min with interval of one week, and each session was performed with a different type of mount material in the following order: 1st performed with saddle and feet in the stirrups (S1), 2nd with saddle and feet off the stirrups (S2), 3rd with blanket and feet off the stirrup (S3) and 4th with blanket and feet in the stirrups (S4)...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29332055/operating-room-scheduling-and-surgeon-assignment-problem-under-surgery-durations-uncertainty
#3
Hongwei Liu, Tianyi Zhang, Shuai Luo, Dan Xu
BACKGROUND: Scientific management methods are urgently needed to balance the demand and supply of heath care services in Chinese hospitals. Operating theatre is the bottleneck and costliest department. Therefore, the surgery scheduling is crucial to hospital management. OBJECTIVE: To increase the utilization and reduce the cost of operating theatre, and to improve surgeons' satisfaction in the meantime, a practical surgery scheduling which could assign the operating room (OR) and surgeon for the surgery and sequence surgeries in each OR was provided for hospital managers...
December 29, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29330441/pathway-design-using-de-novo-steps-through-uncharted-biochemical-spaces
#4
Akhil Kumar, Lin Wang, Chiam Yu Ng, Costas D Maranas
Existing retrosynthesis tools generally traverse production routes from a source to a sink metabolite using known enzymes or de novo steps. Generally, important considerations such as blending known transformations with putative steps, complexity of pathway topology, mass conservation, cofactor balance, thermodynamic feasibility, microbial chassis selection, and cost are largely dealt with in a posteriori fashion. The computational procedure we present here designs bioconversion routes while simultaneously considering any combination of the aforementioned design criteria...
January 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29328873/selecting-and-improving-quasi-experimental-designs-in-effectiveness-and-implementation-research
#5
Margaret A Handley, Courtney R Lyles, Charles McCulloch, Adithya Cattamanchi
Interventional researchers face many design challenges when assessing intervention implementation in real-world settings. Intervention implementation requires holding fast on internal validity needs while incorporating external validity considerations (such as uptake by diverse subpopulations, acceptability, cost, and sustainability). Quasi-experimental designs (QEDs) are increasingly employed to achieve a balance between internal and external validity. Although these designs are often referred to and summarized in terms of logistical benefits, there is still uncertainty about (a) selecting from among various QEDs and (b) developing strategies to strengthen the internal and external validity of QEDs...
January 12, 2018: Annual Review of Public Health
https://www.readbyqxmd.com/read/29326901/short-term-effects-of-theracurmin-dose-and-exercise-type-on-pain-walking-ability-and-muscle-function-in-patients-with-knee-osteoarthritis
#6
Yun-A Shin, Min-Hwa Suk, Hee-Seung Jang, Hye-Jung Choi
The purpose of this study was to investigate the short-term of Theracurmin dose and exercise type on pain, walking ability, and muscle function in patients with knee osteoarthritis. Twenty-five patients with knee osteoarthritis randomly selected to Theracurmin intake (T) group and Theracurmin in combined with exercise (T+E) group. T group (n= 13) was taken orally a capsule of 700 mg, 3 times per day, (total 2,100 mg, 35 mg/kg-body weight). T+E group (n= 12) performed aerobic training of 30-min walking and weight training for increasing leg muscular strength...
December 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29324929/our-solution-for-fusion-of-simultaneusly-acquired-whole-body-scintigrams-and-optical-images-as-usesful-tool-in-clinical-practice-in-patients-with-differentiated-thyroid-carcinomas-after-radioiodine-therapy-a-useful-tool-in-clinical-practice
#7
Milovan Matovic, Milica Jankovic, Marko Barjaktarovic, Marija Jeremic
OBJECTIVE: After radioiodine therapy of differentiated thyroid cancer (DTC) patients, whole body scintigraphy (WBS) is standard procedure before releasing the patient from the hospital. A common problem is the precise localization of regions where the iod-avide tissue is located. Sometimes is practically impossible to perform precise topographic localization of such regions. METHOD: In order to face this problem, we have developed a low-cost Vision-Fusion system for web-camera image acquisition simultaneously with routine scintigraphic whole body acquisition including the algorithm for fusion of images given from both cameras...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29324498/five-steps-to-successfully-implement-and-evaluate-propensity-score-matching-in-clinical-research-studies
#8
Steven J Staffa, David Zurakowski
In clinical research, the gold standard level of evidence is the randomized controlled trial (RCT). The availability of nonrandomized retrospective data is growing; however, a primary concern of analyzing such data is comparability of the treatment groups with respect to confounding variables. Propensity score matching (PSM) aims to equate treatment groups with respect to measured baseline covariates to achieve a comparison with reduced selection bias. It is a valuable statistical methodology that mimics the RCT, and it may create an "apples to apples" comparison while reducing bias due to confounding...
January 9, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29323554/insights-into-breast-cancer-screening-a-computer-simulation-of-two-contemporary-screening-strategies
#9
Kimbroe J Carter, Frank Castro, Roy N Morcos
OBJECTIVE: The debate over the value of screening mammography is rekindled with each new published study or guideline. Central to the discussion are the uncertainties about screening benefits and harms and the criteria used to assess them. Today, the magnitude of benefits for a population is less certain, and the evolving concept of harm has come to encompass false-positives (FPs), unnecessary biopsies, overdiagnosis, and overtreatment. This study uses a Monte Carlo computer simulation to study the balance of benefits and harms of mammographic breast cancer screening for average-risk women...
January 11, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29321139/bmp-smad-pathway-promotes-neurogenesis-of-midbrain-dopaminergic-neurons-in-vivo-and-in-human-induced-pluripotent-and-neural-stem-cells
#10
V M Jovanovic, A Salti, H Tilleman, K Zega, M M Jukic, H Zou, R H Friedel, N Prakash, S Blaess, F Edenhofer, C Brodski
The embryonic formation of midbrain dopaminergic (mDA) neurons in vivo provides critical guidelines for the in vitro differentiation of mDA neurons from stem cells, currently being developed for Parkinson's disease cell replacement therapy. Bone morphogenetic protein (BMP)/SMAD inhibition is routinely used during early steps of stem cell differentiation protocols, including for the generation of mDA neurons. However, the function of the BMP/SMAD pathway for in vivo specification of mammalian mDA neurons is virtually unknown...
January 10, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29320478/an-extracellular-network-of-arabidopsis-leucine-rich-repeat-receptor-kinases
#11
Elwira Smakowska-Luzan, G Adam Mott, Katarzyna Parys, Martin Stegmann, Timothy C Howton, Mehdi Layeghifard, Jana Neuhold, Anita Lehner, Jixiang Kong, Karin Grünwald, Natascha Weinberger, Santosh B Satbhai, Dominik Mayer, Wolfgang Busch, Mathias Madalinski, Peggy Stolt-Bergner, Nicholas J Provart, M Shahid Mukhtar, Cyril Zipfel, Darrell Desveaux, David S Guttman, Youssef Belkhadir
The cells of multicellular organisms receive extracellular signals using surface receptors. The extracellular domains (ECDs) of cell surface receptors function as interaction platforms, and as regulatory modules of receptor activation. Understanding how interactions between ECDs produce signal-competent receptor complexes is challenging because of their low biochemical tractability. In plants, the discovery of ECD interactions is complicated by the massive expansion of receptor families, which creates tremendous potential for changeover in receptor interactions...
January 10, 2018: Nature
https://www.readbyqxmd.com/read/29318172/clinical-factors-that-predict-a-second-acl-injury-after-acl-reconstruction-and-return-to-sport-preliminary-development-of-a-clinical-decision-algorithm
#12
Mark V Paterno, Bin Huang, Staci Thomas, Timothy E Hewett, Laura C Schmitt
Background: Biomechanical predictors of a second anterior cruciate ligament (ACL) injury after ACL reconstruction (ACLR) and return to sport (RTS) have been identified; however, these measures may not be feasible in a standard clinical environment. Purpose/Hypothesis: The purpose of this study was to evaluate whether standard clinical measures predicted the risk of second ACL injuries. The hypothesis tested was that a combination of strength, function, and patient-reported measures at the time of RTS would predict the risk of second ACL injuries with high sensitivity and specificity...
December 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29317105/reduced-center-of-pressure-modulation-elicits-foot-placement-adjustments-but-no-additional-trunk-motion-during-anteroposterior-perturbed-walking
#13
M Vlutters, E H F van Asseldonk, H van der Kooij
Understanding balance during human gait is complicated by the abundance of recovery options. Among all possible recovery options, three main strategies are often considered for human balance control, being the ankle, hip, and foot placement strategies. All can be addressed when balance is threatened during walking, but their relative importance remains uncertain. We have previously shown that healthy human subjects did not significantly adjust their foot placement relative to the body's center of mass (COM) in the first recovery step following anteroposterior pelvis perturbations, as compared to unperturbed walking...
December 24, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29316645/technology-based-feedback-and-its-efficacy-in-improving-gait-parameters-in-patients-with-abnormal-gait-a-systematic-review
#14
REVIEW
Gema Chamorro-Moriana, Antonio José Moreno, José Luis Sevillano
This systematic review synthesized and analyzed clinical findings related to the effectiveness of innovative technological feedback for tackling functional gait recovery. An electronic search of PUBMED, PEDro, WOS, CINAHL, and DIALNET was conducted from January 2011 to December 2016. The main inclusion criteria were: patients with modified or abnormal gait; application of technology-based feedback to deal with functional recovery of gait; any comparison between different kinds of feedback applied by means of technology, or any comparison between technological and non-technological feedback; and randomized controlled trials...
January 6, 2018: Sensors
https://www.readbyqxmd.com/read/29314770/calibration-of-redox-potential-in-sperm-wash-media-and-evaluation-of-oxidation-reduction-potential-values-in-various-assisted-reproductive-technology-culture-media-using-mioxsys-system
#15
M K Panner Selvam, R Henkel, R Sharma, A Agarwal
Oxidation-reduction potential describes the balance between the oxidants and antioxidants in fluids including semen. Various artificial culture media are used in andrology and IVF laboratories for sperm preparation and to support the development of fertilized oocytes under in vitro conditions. The composition and conditions of these media are vital for optimal functioning of the gametes. Currently, there are no data on the status of redox potential of sperm processing and assisted reproduction media. The purpose of this study was to compare the oxidation-reduction potential values of the different media and to calibrate the oxidation-reduction potential values of the sperm wash medium using oxidative stress inducer cumene hydroperoxide and antioxidant ascorbic acid...
January 3, 2018: Andrology
https://www.readbyqxmd.com/read/29311614/closed-loop-control-of-trunk-posture-improves-locomotion-through-the-regulation-of-leg-proprioceptive-feedback-after-spinal-cord-injury
#16
Eduardo Martin Moraud, Joachim von Zitzewitz, Jenifer Miehlbradt, Sophie Wurth, Emanuele Formento, Jack DiGiovanna, Marco Capogrosso, Grégoire Courtine, Silvestro Micera
After spinal cord injury (SCI), sensory feedback circuits critically contribute to leg motor execution. Compelled by the importance to engage these circuits during gait rehabilitation, assistive robotics and training protocols have primarily focused on guiding leg movements to reinforce sensory feedback. Despite the importance of trunk postural dynamics on gait and balance, trunk assistance has comparatively received little attention. Typically, trunk movements are either constrained within bodyweight support systems, or manually adjusted by therapists...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29306299/enhanced-configurational-sampling-with-hybrid-non-equilibrium-molecular-dynamics-monte-carlo-propagator
#17
Donghyuk Suh, Brian K Radak, Christophe Chipot, Benoît Roux
Molecular dynamics (MD) trajectories based on classical equations of motion can be used to sample the configurational space of complex molecular systems. However, brute-force MD often converges slowly due to the ruggedness of the underlying potential energy surface. Several schemes have been proposed to address this problem by effectively smoothing the potential energy surface. However, in order to recover the proper Boltzmann equilibrium probability distribution, these approaches must then rely on statistical reweighting techniques or generate the simulations within a Hamiltonian tempering replica-exchange scheme...
January 7, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29304523/insights-into-3d-structure-of-adamts13-a-stepping-stone-towards-novel-therapeutic-treatment-of-thrombotic-thrombocytopenic-purpura
#18
Bogac Ercig, Kanin Wichapong, Chris P M Reutelingsperger, Karen Vanhoorelbeke, Jan Voorberg, Gerry A F Nicolaes
ADAMTS13 (A D: isintegrin A: nd M: etalloprotease with a T: hromboS: pondin type-1 motif, member 13: ) and von Willebrand factor (VWF) can be considered as scale weights which control platelet adhesion during primary haemostasis. In a very uncommon condition designated thrombotic thrombocytopenic purpura (TTP), functional absence of ADAMTS13 tips the balance toward VWF-mediated platelet adhesion in the microcirculation. TTP is associated with a high mortality and arises from either a congenital or acquired autoimmune deficiency of the plasma enzyme ADAMTS13...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29300857/modelling-interaction-dynamics-between-two-foliar-pathogens-in-wheat-a-multi-scale-approach
#19
Guillaume Garin, Christophe Pradal, Christian Fournier, David Claessen, Vianney Houlès, Corinne Robert
Background and Aims: Disease models can improve our understanding of dynamic interactions in pathosystems and thus support the design of innovative and sustainable strategies of crop protections. However, most epidemiological models focus on a single type of pathogen, ignoring the interactions between different parasites competing on the same host and how they are impacted by properties of the canopy. This study presents a new model of a disease complex coupling two wheat fungal diseases, caused by Zymoseptoria tritici (septoria) and Puccinia triticina (brown rust), respectively, combined with a functional-structural plant model of wheat...
December 29, 2017: Annals of Botany
https://www.readbyqxmd.com/read/29299643/body-foot-geometries-as-revealed-by-perturbed-obstacle-position-with-different-time-constraints
#20
Louis-Philippe Dugas, Laurent J Bouyer, Bradford J McFadyen
This study examined the geometrical relationships between the feet, pelvis and an environmental obstruction when crossing an obstacle with unexpected changes to its position. Nine healthy young adults stepped over an obstacle 19 cm high with their right leg leading. The obstacle could be static or advanced at either lead (early detection) or trail (late detection) foot contact prior to clearance to force an adaptive reorganization of body-foot geometry and foot proximity to the obstacle. Stride length, minimum foot clearance over the obstacle, and foot-obstacle horizontal proximity before and after clearance were measured along with the relative position of the pelvis to each foot at eight points (four for each foot) during approach and clearance: heel contacts before and after crossing the obstacle, maximum foot heights and foot clearances...
January 4, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
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