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https://www.readbyqxmd.com/read/27935560/mobility-measures-differentiate-falls-risk-status-in-persons-with-multiple-sclerosis-an-exploratory-study
#1
Emerson Sebastião, Yvonne C Learmonth, Robert W Motl
BACKGROUND: Falls are of great concern among persons with multiple sclerosis (MS). OBJECTIVE: To examine differences in metrics of mobility, postural control, and cognition in persons with MS with distinct fall risk status; and to investigate predictors of fall risk group membership using discriminant analysis. METHODS: Forty-seven persons with MS completed the Activities-Balance Confidence (ABC) Scale and underwent a battery of assessments of mobility, balance, and cognition...
December 8, 2016: NeuroRehabilitation
https://www.readbyqxmd.com/read/27935091/fabrication-of-complete-dentures-in-three-visits-using-existing-prosthesis-a-simplified-technique-for-geriatric-patients
#2
Rahul S Kulkarni, Ravindra S Pawar
Complete edentulism often limits patients' ability to masticate and perform other oral functions, resulting in a reduction of oral-health-related quality of life. Although the two-implant mandibular overdenture may be considered as a minimum standard of treatment of complete edentulism, patients often prefer conventional complete dentures due to cost and surgical procedures related to implant supported dentures. Many complete denture patients may have limited access to dental care due to socioeconomic or health issues, hence there is a need in simplification of complete denture fabrication...
December 9, 2016: Special Care in Dentistry
https://www.readbyqxmd.com/read/27934794/angiotensin-receptor-blockers-endothelial-dysfunction-possible-correlation-therapeutic-implications
#3
REVIEW
Miroslav Radenkovic, Marko Stojanović, Ivana Milićević Nešić, Milica Prostran
The endothelium is one of the most important constituents of vascular homeostasis, which is achieved through continual and balanced production of different relaxing and contractile factors. When there is a pathological disturbance in release of these products, endothelial dysfunction (ED) will probably occur. ED is considered to be the initial step in the development of atherosclerosis. This pathological activation and inadequate functioning of endothelial cells was shown to be to some extent a reversible process, which all together resulted in increased interest in investigation of different beneficial treatment options...
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27932196/a-mini-volume-loading-test-mvlt-using-2-5-mlkg-1-boluses-of-crystalloid-for-indication-of-perioperative-changes-in-hydration-status
#4
Audrius Andrijauskas, Christer H Svensen, Narūnas Porvaneckas, Jūratė Šipylaitė, Edgaras Stankevičius, Darius Činčikas, Valentinas Uvarovas, Saulė Švedienė, Igoris Šatkauskas, Saulius Vosylius, Giedrius Kvederas
BACKGROUND AND OBJECTIVE: A mini volume loading test (mVLT) evaluating hemodilution during step-wise crystalloid infusion has established that the arterio-capillary plasma dilution difference is inversely correlated to the body hydration level of subjects. This observational study aimed to test whether this can be replicated in a perioperative setting using a 2.5-mLkg(-1) boluses. MATERIALS AND METHODS: The mVLT was performed before induction of regional anesthesia and 24h later...
November 25, 2016: Medicina
https://www.readbyqxmd.com/read/27928454/the-role-of-oral-sodium-bicarbonate-supplementation-in-maintaining-acid-base-balance-and-its-influence-on-the-cardiovascular-system-in-chronic-hemodialysis-patients-results-of-a-prospective-study
#5
Voiculeț C, Zară O, Bogeanu C, Văcăroiu I, Aron G
Background: Major acid-base variations during dialysis and the imbalances in serum calcium levels intensified by them play a role in cardiovascular damage of hemodialysis patients. Early vascular walls modifications can be objectified by determining the pulse wave velocity (PWV) - a marker of vascular stiffness that is associated with increased risk of cardiovascular events. Material and methods: This was a prospective study conducted on 63 chronic hemodialysis patients with diuresis above 500 mL/ 24 hours and predialysis blood pressure below 160 mmHg (treatment controlled) randomized in two groups for 12 months - the study group receiving interdialitic oral sodium bicarbonate doses and control group, without oral sodium bicarbonate supplementation, but receiving higher bicarbonate prescriptions in dialysis...
October 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27925252/the-gpu-enabled-divide-expand-consolidate-ri-mp2-method-dec-ri-mp2
#6
Dmytro Bykov, Thomas Kjaergaard
We report porting of the Divide-Expand-Consolidate Resolution of the Identity second-order Møller-Plesset perturbation (DEC-RI-MP2) method to the graphic processing units (GPUs) using OpenACC compiler directives. It is shown that the OpenACC compiler directives implementation efficiently accelerates the rate-determining step of the DEC-RI-MP2 method with minor implementation effort. Moreover, the GPU acceleration results in a better load balance and thus in an overall scaling improvement of the DEC algorithm...
December 7, 2016: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/27925004/appropriate-osmotic-balance-duration-for-different-volumes-of-ovarian-tissue-in-vitrification-solution-a-study-of-ovary-tissue-vitrification-and-transplantation-in-sheep
#7
L Dang, X Zheng, Q Chang, Y Yang, Y Wang, Y Cai, C Hei, H Wang, C Zhao, W Zhu, Y Wang
:   BACKGROUND: Auto-transplantation of cryopreserved ovarian tissue has become a promising method for fertility preservation and standardization of the process is crucial for practical applications. OBJECTIVE: Here we used different size of large sheep ovarian cortex to study the most suitable osmotic balance durations in the vitrification solution for large piece ovary cortex. MATERIALS AND METHODS: The ovarian cortices from six-month old female sheep were divided into 40 cubic mm, 80 cubic mm and 160 cubic mm volume, A two-step osmotic balance method was used based on the results from morphological and histological study, we detected the expression of VEGF after thawing, the percentage of follicles that survived and serum E2 levels,together with apoptosis test by TUNEL...
September 2016: Cryo Letters
https://www.readbyqxmd.com/read/27924037/human-eif3b-and-eif3a-serve-as-the-nucleation-core-for-the-assembly-of-eif3-into-two-interconnected-modules-the-yeast-like-core-and-the-octamer
#8
Susan Wagner, Anna Herrmannová, Darina Šikrová, Leoš Shivaya Valášek
The 12-subunit mammalian eIF3 is the largest and most complex translation initiation factor and has been implicated in numerous steps of translation initiation, termination and ribosomal recycling. Imbalanced eIF3 expression levels are observed in various types of cancer and developmental disorders, but the consequences of altered eIF3 subunit expression on its overall structure and composition, and on translation in general, remain unclear. We present the first complete in vivo study monitoring the effects of RNAi knockdown of each subunit of human eIF3 on its function, subunit balance and integrity...
October 19, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27923875/accounting-for-protein-subcellular-localization-a-compartmental-map-of-the-rat-liver-proteome
#9
Michel Jadot, Marielle Boonen, Jacqueline Thirion, Nan Wang, Jinchuan Xing, Caifeng Zhao, Abla Tannous, Meiqian Qian, Haiyan Zheng, John K Everett, Dirk F Moore, David E Sleat, Peter Lobel
Accurate knowledge of the intracellular location of proteins is important for numerous areas of biomedical research including assessing fidelity of putative protein-protein interactions, modeling cellular processes at a system-wide level and investigating metabolic and disease pathways. Many proteins have not been localized, or have been incompletely localized, partly because most studies do not account for entire subcellular distribution. Thus, proteins are frequently assigned to one organelle while a significant fraction may reside elsewhere...
December 6, 2016: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/27923175/errors-in-the-ankle-plantarflexor-force-production-are-related-to-the-gait-deficits-of-individuals-with-multiple-sclerosis
#10
Brenda L Davies, Rashelle M Hoffman, Kathleen Healey, Rana Zabad, Max J Kurz
BACKGROUND: Individuals with multiple sclerosis (MS) often have limited mobility that is thought to be due to the neuromuscular impairments of the ankle. Greater isometric motor control of the ankle has been associated with better standing postural balance but its relationship to mobility is less understood. The objectives of this investigation were to quantify the motor control of the ankle plantarflexors of individuals with MS during a dynamic isometric motor task, and explore the relationship between the ankle force control and gait alterations...
December 3, 2016: Human Movement Science
https://www.readbyqxmd.com/read/27921200/testing-an-integrated-model-of-program-implementation-the-food-health-choices-school-based-childhood-obesity-prevention-intervention-process-evaluation
#11
Marissa Burgermaster, Heewon Lee Gray, Elizabeth Tipton, Isobel Contento, Pamela Koch
Childhood obesity is a complex, worldwide problem. Significant resources are invested in its prevention, and high-quality evaluations of these efforts are important. Conducting trials in school settings is complicated, making process evaluations useful for explaining results. Intervention fidelity has been demonstrated to influence outcomes, but others have suggested that other aspects of implementation, including participant responsiveness, should be examined more systematically. During Food, Health & Choices (FHC), a school-based childhood obesity prevention trial designed to test a curriculum and wellness policy taught by trained FHC instructors to fifth grade students in 20 schools during 2012-2013, we assessed relationships among facilitator behaviors (i...
December 5, 2016: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/27916569/insight-into-the-biochemical-kinetic-and-spectroscopic-characterization-of-garlic-allium-sativum-phytocystatin-implication-for-cardiovascular-disease
#12
Mohd Faizan Siddiqui, Azaj Ahmed, Bilqees Bano
Phytocystatins are cysteine proteinase inhibitors present in plants. They play crucial role in maintaining protease-anti protease balance and are involved in various endogenous processes. Thus, they are suitable and convenient targets for genetic engineering which makes their isolation and characterisation from different sources the need of the hour. In the present study a phytocystatin has been isolated from garlic (Allium sativum) by a simple two-step process using ammonium sulphate fractionation and gel filtration chromatography on Sephacryl S-100HR with a fold purification of 152...
December 1, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27915220/stability-maneuverability-trade-offs-during-lateral-steps
#13
Julian Acasio, Mengnan/Mary Wu, Nicholas P Fey, Keith E Gordon
Selecting a specific foot placement strategy to perform walking maneuvers requires the management of several competing factors, including: maintaining stability, positioning oneself to actively generate impulses, and minimizing mechanical energy requirements. These requirements are unlikely to be independent. Our purpose was to determine the impact of lateral foot placement on stability, maneuverability, and energetics during walking maneuvers. Ten able-bodied adults performed laterally-directed walking maneuvers...
November 23, 2016: Gait & Posture
https://www.readbyqxmd.com/read/27913354/a-novel-elastic-force-field-to-influence-mediolateral-foot-placement-during-walking
#14
Elizabeth Nyberg, Jordan Broadway, Christian Finetto, Jesse Dean
Bipedal gait can be stabilized through mechanically-appropriate mediolateral foot placement, although this strategy is disrupted in a subset of neurologically injured individuals with balance deficits. The goal of the present work was to develop a device to influence mediolateral foot placement during treadmill walking. We created a novel force-field using a combination of passive elasticity and active control; wires in series with extension springs run parallel to the treadmill belts and can be rapidly repositioned to exert mediolateral forces on the legs of users...
December 1, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/27912029/how-to-establish-a-bioregenerative-life-support-system-for-long-term-crewed-missions-to-the-moon-or-mars
#15
Yuming Fu, Leyuan Li, Beizhen Xie, Chen Dong, Mingjuan Wang, Boyang Jia, Lingzhi Shao, Yingying Dong, Shengda Deng, Hui Liu, Guanghui Liu, Bojie Liu, Dawei Hu, Hong Liu
To conduct crewed simulation experiments of bioregenerative life support systems on the ground is a critical step for human life support in deep-space exploration. An artificial closed ecosystem named Lunar Palace 1 was built through integrating efficient higher plant cultivation, animal protein production, urine nitrogen recycling, and bioconversion of solid waste. Subsequently, a 105-day, multicrew, closed integrative bioregenerative life support systems experiment in Lunar Palace 1 was carried out from February through May 2014...
December 2, 2016: Astrobiology
https://www.readbyqxmd.com/read/27911566/pedometer-step-count-targets-during-pulmonary-rehabilitation-in-copd-a-randomized-controlled-trial
#16
Claire M Nolan, Matthew Maddocks, Jane L Canavan, Sarah E Jones, Veronica Delogu, Djeya Kaliaraju, Winston Banya, Samantha S C Kon, Michael I Polkey, William D-C Man
RATIONALE: Increasing physical activity is a key therapeutic aim in COPD. Pulmonary rehabilitation (PR) improves exercise capacity, but there is conflicting evidence regarding its ability to improve physical activity levels. OBJECTIVE: To determine whether using pedometers as an adjunct to PR can enhance time spent in at least moderate intensity physical activity (time ≥ 3METs) in people with COPD. METHODS: In this single-blinded randomized controlled trial, participants were assigned 1:1 to receive control (PR comprising 8 weeks, two supervised sessions/week) or intervention (PR plus pedometer-directed step targets, reviewed weekly for 8 weeks)...
December 2, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27910992/tug-of-war-between-two-elastically-coupled-molecular-motors-a-case-study-on-force-generation-and-force-balance
#17
Mehmet Can Uçar, Reinhard Lipowsky
Intracellular transport is performed by molecular motors that pull cargos along cytoskeletal filaments. Many cellular cargos are observed to move bidirectionally, with fast transport in both directions. This behaviour can be understood as a stochastic tug-of-war between two teams of antagonistic motors. The first theoretical model for such a tug-of-war, the Müller-Klumpp-Lipowsky (MKL) model, was based on two simplifying assumptions: (i) both motor teams move with the same velocity in the direction of the stronger team, and (ii) this velocity matching and the associated force balance arise immediately after the rebinding of an unbound motor to the filament...
December 2, 2016: Soft Matter
https://www.readbyqxmd.com/read/27910345/heat-flux-estimates-of-power-balance-on-proto-mpex-with-ir-imaging
#18
M Showers, T M Biewer, J B O Caughman, D C Donovan, R H Goulding, J Rapp
The Prototype Material Plasma Exposure eXperiment (Proto-MPEX) at Oak Ridge National Laboratory (ORNL) is a precursor linear plasma device to the Material Plasma Exposure eXperiment (MPEX), which will study plasma material interactions (PMIs) for future fusion reactors. This paper will discuss the initial steps performed towards completing a power balance on Proto-MPEX to quantify where energy is lost from the plasma, including the relevant diagnostic package implemented. Machine operating parameters that will improve Proto-MPEX's performance may be identified, increasing its PMI research capabilities...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910129/synthesis-of-c-14-radiolabeled-glucagon-receptor-antagonist-and-its-use-in-a-human-mass-balance-study
#19
Boris A Czeskis, Darlene K Satonin
The synthesis of the radiolabeled glucagon receptor antagonist 1-[(14) C] was accomplished based on decarboxylative iodination of acid 2 followed by "reattachment" of (14) C carboxylic function. The method allowed a significant reduction in the number of steps in preparation of the radiolabeled compound. Iodide 4, obtained by the halodecarboxylation, was converted to cyanide 5-[(14) C], which was hydrolyzed to provide the radiolabeled acid 2-[(14) C]. Coupling with β-alanine fragment and hydrolysis of ester 6-[(14) C] completed the synthesis of the target molecule 1-[(14) C]...
December 1, 2016: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/27909435/immune-reconstitution-after-allogeneic-hematopoietic-stem-cell-transplantation
#20
REVIEW
Justyna Ogonek, Mateja Kralj Juric, Sakhila Ghimire, Pavankumar Reddy Varanasi, Ernst Holler, Hildegard Greinix, Eva Weissinger
The timely reconstitution and regain of function of a donor-derived immune system is of utmost importance for the recovery and long-term survival of patients after allogeneic hematopoietic stem cell transplantation (HSCT). Of note, new developments such as umbilical cord blood or haploidentical grafts were associated with prolonged immunodeficiency due to delayed immune reconstitution, raising the need for better understanding and enhancing the process of immune reconstitution and finding strategies to further optimize these transplant procedures...
2016: Frontiers in Immunology
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