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https://www.readbyqxmd.com/read/29792310/bet-inhibition-overcomes-receptor-tyrosine-kinase-mediated-cetuximab-resistance-in-hnscc
#1
Brandon Leonard, Toni M Brand, Rachel A O'Keefe, Eliot Lee, Yan Zang, Jacquelyn D Kemmer, Hua Li, Jennifer R Grandis, Neil E Bhola
Cetuximab, the FDA-approved anti-EGFR antibody for head and neck squamous cell carcinoma (HNSCC), has displayed limited efficacy due to the emergence of intrinsic and acquired resistance. We and others have demonstrated that cetuximab resistance in HNSCC is driven by alternative receptor tyrosine kinases (RTK) including HER3, MET, and AXL. In an effort to overcome cetuximab resistance and circumvent toxicities associated with the administration of multiple RTK inhibitors, we sought to identify a common molecular target that regulates expression of multiple RTK...
May 23, 2018: Cancer Research
https://www.readbyqxmd.com/read/29792227/integrated-time-course-omics-analysis-distinguishes-immediate-therapeutic-response-from-acquired-resistance
#2
Genevieve Stein-O'Brien, Luciane T Kagohara, Sijia Li, Manjusha Thakar, Ruchira Ranaweera, Hiroyuki Ozawa, Haixia Cheng, Michael Considine, Sandra Schmitz, Alexander V Favorov, Ludmila V Danilova, Joseph A Califano, Evgeny Izumchenko, Daria A Gaykalova, Christine H Chung, Elana J Fertig
BACKGROUND: Targeted therapies specifically act by blocking the activity of proteins that are encoded by genes critical for tumorigenesis. However, most cancers acquire resistance and long-term disease remission is rarely observed. Understanding the time course of molecular changes responsible for the development of acquired resistance could enable optimization of patients' treatment options. Clinically, acquired therapeutic resistance can only be studied at a single time point in resistant tumors...
May 23, 2018: Genome Medicine
https://www.readbyqxmd.com/read/29790861/assessing-mr-linac-radiotherapy-robustness-for-anatomical-changes-in-head-and-neck-cancer
#3
Robert W Chuter, Andrew Pollitt, Philip Whitehurst, Ranald I Mackay, Marcel van Herk, Alan McWilliam
The MR-Linac will provide excellent soft tissue contrast for on-treatment imaging. It is well known that the electron return effect (ERE) results in areas of increased and decreased dose at air/tissue boundaries, which can be compensated for in plan optimisation. However, anatomical changes may affect the quality of this compensation. In this paper we aim to quantify the interaction of anatomical changes with ERE in head and neck (H&N) cancer patients.
 
 Twenty patients treated with either 66 Gy or 60 Gy in 30 fractions were selected...
May 23, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29790697/the-inhibition-of-c-myc-transcription-factor-modulates-the-expression-of-glycolytic-and-glutaminolytic-enzymes-in-fadu-hypopharyngeal-carcinoma-cells
#4
Robert Kleszcz, Jarosław Paluszczak, Violetta Krajka-Kuźniak, Wanda Baer-Dubowska
BACKGROUND: Cancer cells are dependent on aerobic glycolysis for energy production and increased glutamine consumption. HIF-1α and c-MYC transcription factors regulate the expression of glycolytic and glutaminolytic genes. Their activity may be repressed by SIRT6. Head and neck carcinomas show frequent activation of c-MYC function and SIRT6 down-regulation, which contributes to a strong dependence on glucose and glutamine availability. OBJECTIVES: The aim of this study was to compare the influence of HIF-1α and c-MYC inhibitors (KG-548 and 10058-F4, respectively) and potential SIRT6 inducers - resveratrol and its synthetic derivative DMU-212 with the effect of glycolysis and glutaminolysis inhibitors (2-deoxyglucose and aminooxyacetic acid, respectively) on the metabolism and expression of metabolic enzymes in FaDu hypopharyngeal carcinoma cells...
May 17, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29790687/expression-profiles-of-selected-genes-in-tumors-and-matched-surgical-margins-in-oral-cavity-cancer-do-we-have-to-pay-attention-to-the-molecular-analysis-of-the-surgical-margins
#5
Joanna K Strzelczyk, Łukasz Krakowczyk, Karolina Gołąbek, Aleksander J Owczarek
BACKGROUND: Head and neck squamous cell carcinomas (HNSCCs) are associated with an interplay between genetics and the environment; they account for 3% of all diagnosed malignant tumors in men and 2% of those in women. OBJECTIVES: The aim of the study was to analyze the significance of TIMP3, SFRP1, SFRP2, CDH1, RASSF1, RORA, and DAPK1 gene expression in head and neck squamous cell carcinoma tumors, and in matching surgical margin samples. We also analyzed the association between clinical parameters and the expression of the selected genes...
April 24, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29790682/assessment-of-quality-of-life-in-patients-with-laryngeal-cancer-a-review-of-articles
#6
REVIEW
Mateusz Kolator, Patrycja Kolator, Tomasz Zatoński
This article presents a review of the medical literature published between 1994 and 2014 with the use of the PubMed database concerning quality-of-life instruments for head and neck cancer patients used to assess general well-being of patients with laryngeal cancer. The PubMed database was searched for articles containing the keywords "quality of life", "laryngeal neoplasm" and "questionnaires". The resulting articles were reviewed and analyzed. After the identification of questionnaires, an additional search was performed...
April 19, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29790672/prognostic-significance-of-combined-pretreatment-lymphocyte-counts-and-body-mass-index-in-patients-with-head-and-neck-cancer-treated-with-radiation-therapy
#7
Yao-Yu Wu, Kai-Ping Chang, Chien-Yu Lin, Ping-Ching Pai, Hung-Ming Wang, Cheng-Lung Hsu, Chun-Ta Liao, Tzu-Chen Yen, Tuan-Jen Fang, Shiang-Fu Huang, Chung-Jan Kang, Ku-Hao Fang, Wan-Ni Lin, Yu-Chien Wang, Li-Jen Hsin, Ngan-Ming Tsang
We aimed to investigate the prognostic significance of combined pretreatment lymphocyte counts (LCs) and body mass index (BMI) in patients with head and neck cancer (HNC) treated with radiation therapy (RT). Nine hundred and twelve patients with HNC who were treated with RT were retrospectively reviewed. Survival was analyzed by stratifying the patients according to pretreatment LCs and BMI. Patients with low pretreatment LCs and BMI were characterized by a more advanced T stage, fewer nasopharyngeal subsites, less smoking and drinking, and fewer comorbidities...
May 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29790306/the-role-of-novel-prognostic-markers-prox1-and-foxc2-in-carcinogenesis-of-oral-squamous-cell-carcinoma
#8
Neha S Agnihotri, Madhusudan Astekar
Oral squamous cell carcinoma is the most common malignant tumor of the head and neck regions and accounts for more than 90% of cancers in the oral cavity. The angiogenesis, lymphangiogenesis and epithelial mesenchymal transition are known to be pivotal for tumor progression and metastasis. In the last decade, much data has been generated concerning the molecular mechanisms of angiogenesis, lymphangiogenesis and its significance in pathological conditions. The main angiogenic and lymphangiogenic factors have been identified as vascular endothelial growth factor A (VEGF-A), vascular endothelial growth factor receptor 2 (VEGFR-2), forkhead box (FOX) C2 while vascular endothelial growth factor C/D (VEGF-C/D), vascular endothelial growth factor receptor 3 (VEGFR-3), Prospero homeobox 1 (PROX1), LYVE-1, podoplanin, Tie/Angioprotein (Ang) 2 and EphrinB2 respectively...
May 2018: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29789760/high-dose-rate-brachytherapy-in-treatment-of-non-melanoma-skin-cancer-of-head-and-neck-region-preliminary-results-of-a-prospective-single-institution-study
#9
Bita Kalaghchi, Ebrahim Esmati, Reza Ghalehtaki, Marzieh Gomar, Ramin Jaberi, Soraya Gholami, Somayyeh Babaloui, Mansoureh Nabavi, Sarvazad Sotoudeh, Nezhat Khanjani, Ali Kazemian, Farnaz Amouzegar-Hashemi, Mahdi Aghili, Marzieh Lashkari
Purpose: Skin cancers are the most common human malignancy with increasing incidence. Currently, surgery is standard of care treatment for non-melanoma skin cancers. However, brachytherapy is a growing modality in the management of skin cancers. Therefore, we aimed to assess the outcome of patients with non-melanoma skin cancers treated by high-dose-rate (HDR) brachytherapy with surface mold technique. Material and methods: In this prospective study, we recruited patients with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin who were candidates for definitive or adjuvant brachytherapy during 2013-2014...
April 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29789167/prevalence-of-malnutrition-and-impact-on-clinical-outcomes-in-cancer-services-a-comparison-of-two-time-points
#10
Kathryn M Marshall, Jenelle Loeliger, Linda Nolte, Amber Kelaart, Nicole K Kiss
BACKGROUND: The prevention and management of malnutrition is increasingly recognised as a significant element of cancer care. By identifying and comparing cancer malnutrition in two large cross-sectional cancer populations, this study aims to provide a greater understanding of clinical characteristics and trajectories relating to cancer malnutrition. METHODS: A multi-centre point prevalence study was conducted in Victoria, Australia at two time points (March 2012, May 2014)...
May 2, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29788875/anti-cancer-and-radio-sensitizing-effects-of-curcumin-in-nasopharyngeal-carcinoma
#11
Amir Abbas Momtazi, Faezeh Ghasemi, Amirreza Hesari, Muhammed Majeed, Michele Caraglia, Amirhossein Sahebkar
Nasopharyngeal cancer (NPC) is a rare type of head and neck cancer that is mainly treated by radiotherapy, but sometimes it is radioresistant. Curcumin is a polyphenolic natural product with established anti-cancer effects in various human cancers. Recent studies have shown that curcumin has therapeutic and radio-sensitizing effects on NPC cells. In fact, it has been found that curcumin can sensitize NPC cells to radiation through different mechanisms, including modulation of ROS generation, Jab1/CSN5 and non-coding RNAs...
May 21, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29788865/editorial-head-and-neck-cancer-recent-findings-and-new-targets
#12
EDITORIAL
F Ardito, L Muzio, M N Dias Soeiro Cordeiro, R Concu
No abstract text is available yet for this article.
2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29787349/head-and-neck-cancer-patients-rates-reasons-and-risk-factors-for-30-day-unplanned-readmission
#13
Michael K Ghiam, Alexander Langerman, Zoukaa Sargi, Sarah Rohde
Objective To analyze rates, risk factors, and complications for 30-day readmission among head and neck cancer (HNC) patients. Methods Retrospective review of administrative records from Vizient (Irving, Texas) Clinical Data Base/Resource Manager on HNC patients who underwent a head and neck surgical procedure from January 2013 through September 2015 at 176 academic and community medical centers. Results Of the 18,121 patients included in the study, 2502 patients were readmitted within 30 days (13.8%). Mean time to readmission was 11 ± 8...
May 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29785934/imaging-modalities-in-the-etiologic-evaluation-of-unilateral-vocal-fold-paralysis
#14
Suat Bilici, Muhammet Yildiz, Ozgur Yigit, Esra Misir
OBJECTIVE: This study aimed to investigate the roles of computed tomography (CT) and neck ultrasonography (US) in evaluating unilateral vocal fold paralysis (UVFP) of unknown etiology and to compare our results with those of other studies to assess the differences in etiology of UVFP. METHODS: We investigated the medical records of 202 eligible patients with UVFP. In total, 168 underwent chest CT, 118 underwent neck CT, and 108 underwent head CT. One hundred and three patients were also evaluated with high-resolution neck US...
May 18, 2018: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29785718/associations-between-the-smoking-relatedness-of-a-cancer-type-cessation-attitudes-and-beliefs-and-future-abstinence-among-recent-quitters
#15
Úrsula Martínez, Thomas H Brandon, Steven K Sutton, Vani N Simmons
OBJECTIVE: Smoking after a diagnosis of cancer can negatively impact treatment outcomes and quality of life. It is important that patients quit smoking and remain abstinent regardless of cancer type. Some cancer types (e.g., lung) have stronger links to smoking as a cause than do others (e.g., colorectal). The aims of this study were to (1) assess associations between smoking-relatedness of the cancer type with beliefs and attitudes concerning smoking abstinence (e.g., confidence, self-efficacy), and (2) assess these variables as predictors of future abstinence...
May 21, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29785183/evaluation-of-reirradiation-in-locally-advanced-head-and-neck-cancers-toxicity-and-early-clinical-outcomes
#16
Amit Bahl, Arun Singh Oinam, Arun Elangovan, Satinder Kaur, Gaurav Trivedi, Roshan Verma, Sudhir Bhandari, Sushmita Ghoshal, Naresh Kumar Panda
Objectives: Locoregional recurrence is the predominant pattern of treatment failure in advanced head and neck cancers. Reirradiation is a useful modality to treat inoperable head and neck cancer patients with recurrent disease. The aim of the present study was to analyze the treatment toxicity and early clinical outcomes in patients undergoing reirradiation. Methods: Twenty patients of head and neck cancers with recurrences or second cancers were evaluated. Reirradiation was done using simultaneous integrated boost volumetric modulated arc therapy (SIB VMAT), intensity modulated radiotherapy (IMRT), or conventional radiotherapy using 6MV photons...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/29785159/assessment-of-the-quality-of-life-and-performance-status-in-patients-with-oral-submucous-fibrosis-in-central-india
#17
Revant H Chole, Ranjitkumar Patil
Background and aims: Measuring quality of life in patients with oral submucous fibrosis is of utmost importance in assessing treatment outcomes. This study examined the impact of oral submucous fibrosis and its treatment on the quality of life and performance status of persons with oral submucous fibrosis. Methods: Quality of life was measured in patients with oral submucous fibrosis using the European Organization for Research and Treatment of Cancer Quality of Life head and neck 35 Questionnaire (EORTC QLQ-C35); performance status was measured by Performance Status Scale for Head and Neck Cancer Patients (PSS-HN), at four points in time: baseline, one month, two months and three months after start of treatment...
2018: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29784752/head-and-neck-cancers-advantages-of-advanced-radiation-therapy-and-importance-of-supportive-care
#18
Sharon Spencer
For more than a decade, the incidence of head and neck cancers has been increasing in the United States. Worldwide, they are the ninth most common cancer. Today, newer advances in radiotherapy (RT), such as fractionation, 4-dimensional cone-beam CT, and intensity-modulated RT, have provided clinicians with the opportunity for improved patient outcomes. At the NCCN 23rd Annual Conference, Sharon Spencer, MD, described the advantages of advances in RT and the means to mitigate untoward side effects.
May 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29784145/the-effect-of-the-use-of-thyme-honey-in-minimizing-radiation-induced-oral-mucositis-in-head-and-neck-cancer-patients-a-randomized-controlled-trial
#19
Melanie Charalambous, Vasilios Raftopoulos, Lefkios Paikousis, Nicos Katodritis, Ekaterini Lambrinou, Dimitrios Vomvas, Morpho Georgiou, Andreas Charalambous
PURPOSE: Radiation-induced oral mucositis is one of the main side effects during and after the treatment of head and neck cancer patients. The study was designed to provide evidence on the effectiveness of thyme honey on oral mucositis management. METHODS: This was a randomised controlled trial (RCT) with 72 head and neck cancer patients who were divided either to the intervention group (thyme honey rinses) or to the control group (saline rinses). Oral mucositis was assessed according to the Radiation Therapy Oncology Group (RTOC criteria), and assessments were performed weekly starting at the 4th week of the radiotherapy for seven weeks and repeated once 6 months later...
June 2018: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/29783911/can-predictive-modeling-identify-head-and-neck-oncology-patients-at-risk-for-readmission
#20
Amy M Manning, Keith A Casper, Kay St Peter, Keith M Wilson, Jonathan R Mark, Ryan M Collar
Objective Unplanned readmission within 30 days is a contributor to health care costs in the United States. The use of predictive modeling during hospitalization to identify patients at risk for readmission offers a novel approach to quality improvement and cost reduction. Study Design Two-phase study including retrospective analysis of prospectively collected data followed by prospective longitudinal study. Setting Tertiary academic medical center. Subjects and Methods Prospectively collected data for patients undergoing surgical treatment for head and neck cancer from January 2013 to January 2015 were used to build predictive models for readmission within 30 days of discharge using logistic regression, classification and regression tree (CART) analysis, and random forests...
May 1, 2018: Otolaryngology—Head and Neck Surgery
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