keyword
MENU ▼
Read by QxMD icon Read
search

ET-1 AND blood pressure

keyword
https://www.readbyqxmd.com/read/29449619/chronic-et-a-antagonist-reverses-hypertension-and-impairment-of-structure-and-function-of-peripheral-small-arteries-in-aortic-stiffening
#1
Xiaomei Guo, Huan Chen, Ling Han, Stephan Haulon, Ghassan S Kassab
Arterial stiffness may contribute to the pathogenesis of hypertension. The goal of this study is to elucidate the role of Endothelin-1 (ET-1) in aortic stiffening-induced hypertension through ET A receptor activation. An increase in aortic stiffness was created by use of a non-constrictive restraint, NCR on the abdominal aortic surface. A group of rats underwent aortic NCR or sham operation for 12 weeks and were then treated with ET A receptor antagonist BQ-123 for 3 weeks. We found that 12 weeks of aortic NCR significantly increased pulse and mean pressure and altered peripheral flow pattern, accompanied by an increased serum ET-1 level (p < 0...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29448245/a-genetic-variant-associated-with-the-five-vascular-diseases-is-a-distal-regulator-of-endothelin-1-gene-expression
#2
Ernesto L Schiffrin
Gupta et al. [Cell 2017; 170: 522-533] have shown that a genetic variant associated with the 5 vascular diseases is a distal regulator of endothelin (ET)-1 gene (EDN1) expression. A common single nucleotide polymorphism (SNP) in the third intron of the PHACTR1 gene, rs9349379, is the potential variant responsible for increased risk of coronary artery disease, and lower risk of migraine, carotid dissection, fibromuscular dysplasia, and hypertension. Since ET-1 acts through ET type B receptors (ETBR) on endothelial cells to stimulate the production of nitric oxide and prostacyclin and induce vasodilation, this may contribute to these findings...
February 15, 2018: Nephron
https://www.readbyqxmd.com/read/29412230/protective-effect-of-dexmedetomidine-against-myocardial-ischemia-reperfusion-injury-in-rabbits
#3
Jianjun Ren, Changfa Li, Yan Liu, Haitao Liu, Zhenming Dong
PURPOSE: To investigate the influence of dexmedetomidine on myocardial ischemia-reperfusion injury (IRI) in rabbits. METHODS: Twenty-four New Zealand white rabbits were randomly divided into two equal-sized groups: IRI group (group IR) and dexmedetomidine group (group D). Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), left ventricular diastolic pressure (LVDP), +dp/dtmax, -dp/dtmax, and t-dp/dtmax were recorded and calculated at the following time points: before (T0) and after (T1) dexmedetomidine infusion, after 30-min ischemia (T2), and after 120-min reperfusion (T3)...
January 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29360807/anti-proteinuric-effect-of-an-endothelin-1-receptor-antagonist-in-puromycin-aminonucleoside-induced-nephrosis-in-rat
#4
Jiro Kino, Shoji Tsuji, Tetsuya Kitao, Yuko Akagawa, Sohsaku Yamanouchi, Takahisa Kimata, Kazunari Kaneko
BACKGROUND: The pathogenesis of idiopathic nephrotic syndrome (INS) remains unclear although recent studies suggest endothelin 1 (ET-1) and CD80 of podocytes are involved. We investigated the potential of antagonist to ET-1 receptor type A (ETRA) as therapeutic agent through suppression of CD80 in rat model of INS. METHODS: Puromycin aminonucleoside (PAN) was injected to Wister rats to induce proteinuria: some were treated with ETRA antagonist and others were treated with 0...
January 23, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29358853/serum-levels-of-angiotensin-converting-enzyme-as-a-biomarker-of-liver-fibrosis
#5
EDITORIAL
Aline Silva Miranda, Ana Cristina Simões E Silva
The renin angiotensin system (RAS) is classically conceived as a circulating hormonal system involved in blood pressure control and hydroelectrolyte balance. The discovery that RAS components are locally expressed in a wide range of organs and tissues, including the liver, pointed to a role for this system in the pathogenesis of several conditions including hepatic fibrosis and cirrhosis. It has been widely reported that the classical RAS axis composed by the angiotensin converting enzyme (ACE)-angiotensin (Ang) II-Ang type 1 (AT1) receptor mediates pro-inflammatory, pro-thrombotic, and pro-fibrotic processes...
December 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29355738/carbonic-anhydrase-ii-does-not-exhibit-nitrate-reductase-or-nitrous-anhydrase-activity
#6
Jacob T Andring, Carrie L Lomelino, Chingkuang Tu, David N Silverman, Robert McKenna, Erik R Swenson
Carbonic anhydrase II (CA II) is a zinc metalloenzyme that catalyzes the reversible interconversion of water and CO2 to bicarbonate and a proton. CA II is abundant in most cells, and plays a role in numerous processes including gas exchange, epithelial ion transport, respiration, extra- and intracellular pH control, and vascular regulation. Beyond these CO2 and pH-linked roles, it has been postulated that CA II might also reduce nitrite (NO2-) to nitric oxide (NO), as bicarbonate and NO2- both exhibit sp2 molecular geometry and NO also plays an important role in vasodilation and regulation of blood pressure...
January 16, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29351432/diurnal-pattern-in-skin-na-and-water-content-is-associated-with-salt-sensitive-hypertension-in-etb-receptor-deficient-rats
#7
Joshua S Speed, Kelly A Hyndman, Malgorzata Kasztan, Jermaine G Johnston, Kaehler J Roth, Jens M Titze, David M Pollock
Impairment in the ability of the skin to properly store Na+ non-osmotically (without water) has recently been hypothesized as contributing to salt-sensitive hypertension. Our lab has shown that endothelial production of endothelin-1 (ET-1) is crucial to skin Na+ handling. Further, it is well established that loss of ETB receptor function impairs Na+ excretion by the kidney. Thus we hypothesized that rats lacking functional ETB receptors (ETB def) will have a reduced capacity of the skin to store Na+ during chronic high salt (HS) intake...
December 13, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29305232/comparison-of-different-maximal-oxygen-uptake-equations-to-discriminate-the-cardiometabolic-risk-in-children-and-adolescents
#8
Robinson Ramírez-Vélez, Jorge Enrique Correa-Bautista, Jorge Mota, Antonio Garcia-Hermoso
OBJECTIVE: To determine the ability of 8 different maximal oxygen uptake (VO2max) equations to discriminate between low and high cardiometabolic risk, and to determine cardiorespiratory fitness (CRF) cutoffs associated with a more favorable cardiometabolic risk profile in Colombian children and adolescents. STUDY DESIGN: In a cross-sectional study, CRF was estimated using the 20-m shuttle run test in 2870 schoolchildren (54.5% girls) from Bogota, Colombia. We computed a metabolic syndrome score (MetScore) as the sum of the age- and sex-standardized scores of waist circumference, triglycerides, high-density lipoprotein cholesterol, glucose, and systolic and diastolic blood pressure...
January 3, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29285176/efficacy-of-continuous-positive-airway-pressure-treatment-in-treating-obstructive-sleep-apnea-hypopnea-syndrome-associated-with-carotid-arteriosclerosis
#9
Yong-Qian Jiang, Jin-Shan Xue, Juan Xu, Zhi-Xiang Zhou, You-Lin Ji
Sleep apnea negatively impacts patients' ability to oxygenate the bloodstream during sleep and has far-reaching, deleterious effects. The present study sought to assess the correlation between obstructive sleep apnea hypopnea syndrome (OSAHS), carotid atherosclerosis, and blood pressure variability (BPV), and to evaluate the therapeutic effects of continuous positive airway pressure (CPAP). Patients with OSAHS were classified as mild, moderate, or severe according to their condition and compared with healthy control participants...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29231988/methylation-based-estimated-biological-age-and-cardiovascular-disease
#10
Lars Lind, Erik Ingelsson, Johan Sundström, Agneta Siegbahn, Erik Lampa
BACKGROUND: DNA methylation changes over life at specific sites in the genome, which can be used to estimate "biological age". The aim of this population-based longitudinal cohort study was to investigate the association between estimated biological age and incident cardiovascular disease (CVD). MATERIALS AND METHODS: Based on formulas published by Hannum et al and Horvath et al, "biological age" was calculated using data from the Illumina 450k Bead Methylation chip in 832 participants free from cardiovascular disease in the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study (50% women, all aged 70 years at the examination)...
December 12, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29225514/elevation-of-small-dense-low-density-lipoprotein-cholesterol-a-possible-antecedent-of-atherogenic-lipoprotein-phenotype-in-type-2-diabetes-patients-in-jos-north-central-nigeria
#11
Kenneth O Inaku, Obasola O Ogunkeye, Fayeofori M Abbiyesuku, Evelyn K Chuhwak, Christian O Isichei, Lucius C Imoh, Noel O Amadu, Alexander O Abu
Background: The global prevalence of type 2 diabetes is increasing. Dyslipidaemia is a known complication of diabetes mellitus manifesting frequently as cardiovascular diseases and stoke. Elevation of small, dense low density lipoprotein has been recognised as a component of the atherogenic lipoprotein phenotype associated with cardiovascular complications. We speculate that the elevation of this lipoprotein particle may be the antecedent of the atherogenic lipoprotein phenotype. This study therefore aims to determine the pattern of dyslipidaemia among diabetes mellitus patients in Jos, North-Central Nigeria...
2017: BMC Clinical Pathology
https://www.readbyqxmd.com/read/29214526/high-intensity-interval-training-lowers-blood-pressure-and-improves-apelin-and-nox-plasma-levels-in-older-treated-hypertensive-individuals
#12
Mohammad Reza Izadi, Alireza Ghardashi Afousi, Maryam Asvadi Fard, Mohammad Ali Babaee Bigi
Hypertension is the major risk factor for cardiovascular diseases and is one of the primary causes of morbidity and mortality worldwide. Apelin levels and NO bioavailability are impaired in older hypertensive patients. Exercise is an effective intervention for treating hypertension. Our purpose was to evaluate the effect of high-intensity interval training on blood pressure, apelin, and NOx plasma levels in older treated hypertensive individuals. Thirty treated hypertensive subjects (61.70 ± 5.78 years, 17 males, 13 females) were randomly divided into 6 weeks of high-intensity interval training (n = 15) and control (n = 15)...
December 6, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29212810/heme-oxygenase-1-is-a-potent-inhibitor-of-placental-ischemia-mediated-endothelin-1-production-in-cultured-human-glomerular-endothelial-cells
#13
Bhavisha A Bakrania, Frank T Spradley, Simon C Satchell, David E Stec, John M Rimoldi, Rama S V Gadepalli, Joey P Granger
Preeclampsia is a pregnancy-specific disorder of maternal hypertension and reduced renal hemodynamics linked to reduced endothelial function. Placental ischemia is thought to be the culprit of this disease, as it causes the release of factors like tumor necrosis factor (TNF)-α that induce vascular endothelin-1 (ET-1) production. Interestingly, placental ischemia-induced hypertension in rats (reduced uterine perfusion pressure, RUPP model) is abolished by ETA receptor blockade, suggesting a critical role for ET-1...
December 6, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29212079/plasma-et-1-concentrations-are-elevated-in-pregnant-women-with-hypertension-meta-analysis-of-clinical-studies
#14
Yong-Ping Lu, Ahmed Abdallah Hasan, Shufei Zeng, Berthold Hocher
BACKGROUND/AIMS: The ET system might be involved in the pathogenesis of hypertensive disorders during pregnancy. The objective is to analyse the impact of ET-1 in hypertensive pregnant women by a strict meta-analysis of published human clinical studies. METHODS: Based on the principle of Cochrane systematic reviews, Cohort studies in PubMed (Medline), Google Scholar and China Biological Medicine Database (CBM-disc) designed to identify the role of endothelin-1 (ET-1) in the pathophysiology of gestational hypertension and preeclampsia were screened...
November 28, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29151418/-vegf165-transfected-endothelial-progenitor-cells-mediated-by-lentivirus-alleviated-ali-in-rats
#15
Zhaohui He, Huiwei He, Yuanhua Lu, Zhi Chen, Fanghua Xu, Rongsheng Wang, Chunli Yang
OBJECTIVE: To investigate the protective effects of vascular endothelial growth factor-165 (VEGF165) transfected the endothelial progenitor cells (EPCs) mediated by lentivirus on acute lung injury (ALI) in rats. METHODS: The mononuclear cells from the male Sprague-Dawley (SD) rats were isolated and cultured to get the EPCs for study. The lentivirus vector carrying the human VEGF165 gene was constructed. According to the random number table method, 90 male SD rats were divided into ALI model group, phosphate buffer solution (PBS) group, EPCs treatment group, none transfected EPCs treatment group and VEGF165 transfected EPCs treatment group, and the rats in each group were subdivided into 4, 12 and 48 hours subgroups, with 6 rats in each subgroup...
November 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29133362/three-month-endothelial-human-endothelin-1-overexpression-causes-blood-pressure-elevation-and-vascular-and-kidney-injury
#16
Suellen C Coelho, Olga Berillo, Antoine Caillon, Sofiane Ouerd, Júlio C Fraulob-Aquino, Tlili Barhoumi, Stefan Offermanns, Pierre Paradis, Ernesto L Schiffrin
Endothelium-derived endothelin (ET)-1 has been implicated in the development of hypertension and end-organ damage, but its exact role remains unclear. We have shown that tamoxifen-inducible endothelium-restricted human ET-1 overexpressing (ieET-1) mice exhibited blood pressure rise after a 3-week induction in an ET type A (ETA) receptor-dependent manner, in absence of vascular and renal injury. It is unknown whether long-term ET-1 overexpression results in sustained blood pressure elevation and vascular and renal injury...
November 13, 2017: Hypertension
https://www.readbyqxmd.com/read/29106302/comparative-study-on-the-effects-of-apple-peel-polyphenols-and-apple-flesh-polyphenols-on-cardiovascular-risk-factors-in-mice
#17
Jia Tian, Xiaoyan Wu, Moyang Zhang, Zhongyi Zhou, Yingfeng Liu
Apple consumption has been demonstrated to be associated with reduced risk of cardiovascular disease, and the beneficial effect is probably due to the polyphenols in apple. Here, we for the first time evaluated and compared the in vivo effects of the polyphenolic extracts of apple peels (PAP) and apple fleshes (PAF) on blood pressure, vascular endothelial function, lipid metabolism and insulin resistance. A high-fat and high-fructose (HFHF) diet was used to cause cardiovascular disorders in mice, with blood pressure, serum ET-1, TC, TG, LDL-C, glucose and insulin levels increased, and serum NO and HDL-C levels decreased...
November 6, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29062873/the-effect-of-reducing-the-incidence-of-gastrointestinal-complications-in-patients-treated-with-aspirin-referred-to-imam-hospital-of-ahvaz-iran
#18
Abdalrahim Masjedizade, Mohammad Javad Mohammadi, Saeed Yazdankhah, Atefeh Roumi, Arman Shahriari, Sahar Geravandi
This research contains data which were obtained during the analysis of treated patients with aspirin who were referred to Imam Hospital (Imam H) of Ahvaz, Iran; and the effect of this type of treatment (Helicobacter pylori eradicate (HPE)) on reducing the incidence of gastrointestinal complications. Studies have shown that taking aspirin in patients with Helicobacter pylori infection is associated with a decreasing risk of gastrointestinal bleeding (O'connor et al., 2013) [1]. In this study, 165 patients with positive helicobacter pylori infection test were chosen among those who were referred to Imam H...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/29061720/role-of-kidneys-in-sex-differences-in-angiotensin-ii-induced-hypertension
#19
Lei Wang, Ximing Wang, Helena Y Qu, Shan Jiang, Jie Zhang, Liying Fu, Jacentha Buggs, Bo Pang, Jin Wei, Ruisheng Liu
The significance of kidneys in regulation of sodium and water balance and hemodynamics has been demonstrated both in patients and animal models. In the present study, we tested our hypothesis that kidneys play an essential role in control of sex differences in angiotensin II (Ang II)-dependent hypertension. Kidney transplantations (KTXs) were performed between male (M) and female (F) C57BL/6 mice (donor→recipient: F→F, M→M, F→M, and M→F). Radiotelemetry transmitters were implanted for measurement of mean arterial pressure during the infusion of Ang II (600 ng·kg(-1)·min(-1))...
October 23, 2017: Hypertension
https://www.readbyqxmd.com/read/29051112/in-vivo-and-in-silico-evaluation-of-a-new-nitric-oxide-donor-s-s-dinitrosobucillamine
#20
Marie-Lynda Bouressam, Benjamin Meyer, Ariane Boudier, Igor Clarot, Pierre Leroy, Alessandro Genoni, Manuel Ruiz-Lopez, Philippe Giummelly, Patrick Liminana, Valérie Salgues, Mostafa Kouach, Caroline Perrin-Sarrado, Isabelle Lartaud, François Dupuis
PURPOSE: In a previous work, we have synthetized a new dinitrosothiol, i.e. S,S'-dinitrosobucillamine BUC(NO)2 combining S-nitroso-N-acetylpenicillamine (SNAP) and S-nitroso-N-acetylcysteine (NACNO) in its structure. When exposed to isolated aorta, we observed a 1.5-fold increase of (•)NO content and a more potent vasorelaxation (1 log higher pD2) compared to NACNO and SNAP alone or combined (Dahboul et al., 2014). In the present study, we analyzed the thermodynamics and kinetics for the release of (•)NO through computational modeling techniques and correlated it to plasma assays...
October 16, 2017: Nitric Oxide: Biology and Chemistry
keyword
keyword
74855
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"