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https://www.readbyqxmd.com/read/27866413/disbalance-of-calcium-regulation-related-genes-in-heart-of-broilers-induced-by-selenium-deficiency
#1
Ziwei Zhang, Man Liu, Zhenqiong Guan, Jie Yang, Zhonghua Liu, Shiwen Xu
Dietary selenium (Se) deficiency may influence the calcium (Ca) homeostasis in broilers. Our objective was to investigate the effects of Se deficiency on Ca regulation related genes' change in heart of broilers. In the present study, 1-day-old broilers were fed either a commercial diet (as control group) with 0.15 mg/kg Se or a Se-deficient diet (as L group) with 0.033 mg/kg Se for 35 days. We examined the mRNA expression levels of 15 Ca regulation related genes (ITPR 1, ITPR 2, ITPR3, RyR2, RyR3, SERCA1s, SLC8A1, PMCA1, CACNA1S, TRPC1, TRPC3, STIM1, ORAI1, CaLM and CRT) in the heart of broilers...
November 21, 2016: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/27617218/identification-of-trpcs-genetic-variants-that-modify-risk-for-lung-cancer-based-on-the-pathway-and-two-stage-study
#2
Zili Zhang, Jian Wang, Jianxing He, Xiansheng Zeng, Xindong Chen, Mingmei Xiong, Qipeng Zhou, Meihua Guo, Defu Li, Wenju Lu
OBJECTIVE: Store operated calcium channels (SOCCs) and Receptor-operated calcium channels (ROCCs) are important pathways participating in regulation of intracellular Ca(2 +) concentration in various cell types. The purpose of our study is to determine whether genetic variations in key components of SOCCs and ROCCs are associated with lung cancer risk. METHODS: We identified 236 tagSNPs in 9 key genes related to SOCCs and ROCCs (TRPC1, TRPC3, TRPC4, TRPC6, TRPC7, ORAI1, ORAI2, STIM1, and STIM2) and evaluated their association with lung cancer risk in a two-stage case-control study with a total of 2433 lung cancer cases and 2433 cancer-free controls using Illumina high throughput genotyping platform...
September 2016: Meta Gene
https://www.readbyqxmd.com/read/27557522/selenoprotein-w-redox-regulated-ca2-channels-correlate-with-selenium-deficiency-induced-muscles-ca2-leak
#3
Haidong Yao, Ruifeng Fan, Xia Zhao, Wenchao Zhao, Wei Liu, Jie Yang, Hamid Sattar, Jinxin Zhao, Ziwei Zhang, Shiwen Xu
Selenium (Se) deficiency induces Ca2+ leak and calcification in mammal skeletal muscles; however, the exact mechanism is still unclear. In the present study, both Se-deficient chicken muscle models and selenoprotein W (SelW) gene knockdown myoblast and embryo models were used to study the mechanism. The results showed that Se deficiency-induced typical muscular injuries accompanied with Ca2+ leak and oxidative stress (P < 0.05) injured the ultrastructure of the sarcoplasmic reticulum (SR) and mitochondria; decreased the levels of the Ca2+ channels, SERCA, SLC8A, CACNA1S, ORAI1, STIM1, TRPC1, and TRPC3 (P < 0...
August 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/26592972/calcium-signalling-in-salivary-gland-physiology-and-dysfunction
#4
Indu S Ambudkar
Studies over the past four decades have established that Ca(2+) is a critical factor in control of salivary gland function and have led to identification of the critical components of this process. The major ion transport mechanisms and ion channels that are involved in fluid secretion have also been established. The key event in activation of fluid secretion is an increase in [Ca(2+) ]i triggered by inositol 1,4,5-trisphosphate (IP3 )-induced release of Ca(2+) from ER via the IP3 receptor (IP3 R). IP3 Rs determine the site of initiation and the pattern of the [Ca(2+) ]i signal in the cell...
June 1, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/26494622/store-operated-ca2-entry-mediated-by-orai1-and-trpc1-participates-to-insulin-secretion-in-rat-%C3%AE-cells
#5
Jessica Sabourin, Loïc Le Gal, Lisa Saurwein, Jacques-Antoine Haefliger, Eric Raddatz, Florent Allagnat
Store-operated Ca(2+) channels (SOCs) are voltage-independent Ca(2+) channels activated upon depletion of the endoplasmic reticulum Ca(2+) stores. Early studies suggest the contribution of such channels to Ca(2+) homeostasis in insulin-secreting pancreatic β-cells. However, their composition and contribution to glucose-stimulated insulin secretion (GSIS) remains unclear. In this study, endoplasmic reticulum Ca(2+) depletion triggered by acetylcholine (ACh) or thapsigargin stimulated the formation of a ternary complex composed of Orai1, TRPC1, and STIM1, the key proteins involved in the formation of SOCs...
December 18, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26075746/mechanisms-of-cigarette-smoke-effects-on-human-airway-smooth-muscle
#6
Mark E Wylam, Venkatachalem Sathish, Sarah Kay VanOosten, Michelle Freeman, David Burkholder, Michael A Thompson, Christina M Pabelick, Y S Prakash
Cigarette smoke contributes to or exacerbates airway diseases such as asthma and COPD, where airway hyperresponsiveness and airway smooth muscle (ASM) proliferation are key features. While factors such as inflammation contribute to asthma in part by enhancing agonist-induced intracellular Ca(2+) ([Ca(2+)]i) responses of ASM, the mechanisms by which cigarette smoke affect ASM are still under investigation. In the present study, we tested the hypothesis that cigarette smoke enhances the expression and function of Ca(2+) regulatory proteins leading to increased store operated Ca(2+) entry (SOCE) and cell proliferation...
2015: PloS One
https://www.readbyqxmd.com/read/25859221/the-involvement-of-trpc3-channels-in-sinoatrial-arrhythmias
#7
Yue-Kun Ju, Bon Hyang Lee, Sofie Trajanovska, Gouliang Hao, David G Allen, Ming Lei, Mark B Cannell
Atrial fibrillation (AF) is a significant contributor to cardiovascular morbidity and mortality. The currently available treatments are limited and AF continues to be a major clinical challenge. Clinical studies have shown that AF is frequently associated with dysfunction in the sino-atrial node (SAN). The association between AF and SAN dysfunction is probably related to the communication between the SAN and the surrounding atrial cells that form the SAN-atrial pacemaker complex and/or pathological processes that affect both the SAN and atrial simultaneously...
2015: Frontiers in Physiology
https://www.readbyqxmd.com/read/25741599/trpc1-mediated-ca%C3%A2-%C3%A2-%C2%BA-entry-is-essential-for-the-regulation-of-hypoxia-and-nutrient-depletion-dependent-autophagy
#8
P Sukumaran, Y Sun, M Vyas, B B Singh
Autophagy is a cellular catabolic process needed for the degradation and recycling of protein aggregates and damaged organelles. Although Ca(2+) is suggested to have an important role in cell survival, the ion channel(s) involved in autophagy have not been identified. Here we demonstrate that increase in intracellular Ca(2+) via transient receptor potential canonical channel-1 (TRPC1) regulates autophagy, thereby preventing cell death in two morphologically distinct cells lines. The addition of DMOG or DFO, a cell permeable hypoxia-mimetic agents, or serum starvation, induces autophagy in both epithelial and neuronal cells...
March 5, 2015: Cell Death & Disease
https://www.readbyqxmd.com/read/25533457/stim1-and-stim2-proteins-differently-regulate-endogenous-store-operated-channels-in-hek293-cells
#9
Alexey Shalygin, Anton Skopin, Vera Kalinina, Olga Zimina, Lyuba Glushankova, Galina N Mozhayeva, Elena Kaznacheyeva
The endoplasmic reticulum calcium sensors stromal interaction molecules 1 and 2 (STIM1 and STIM2) are key modulators of store-operated calcium entry. Both these sensors play a major role in physiological functions in normal tissue and in pathology, but available data on native STIM2-regulated plasma membrane channels are scarce. Only a few studies have recorded STIM2-induced CRAC (calcium release-activated calcium) currents. On the other hand, many cell types display store-operated currents different from CRAC...
February 20, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/25088676/stim1-regulates-trpc6-heteromultimerization-and-subcellular-location
#10
Letizia Albarrán, Natalia Dionisio, Esther Lopez, Ginés M Salido, Pedro C Redondo, Juan A Rosado
STIM1 (stromal interaction molecule 1) regulates store-operated channels in the plasma membrane, but the regulation of TRPC (transient receptor potential canonical) heteromultimerization and location by STIM1 is poorly understood. STIM1 is a single transmembrane protein that communicates the filling state of the endoplasmic reticulum to store-operated channels. STIM1 has been reported to regulate the activity of all of the TRPC family members, except TRPC7. TRPC6 has been predominantly associated to second messenger-activated Ca2+ entry pathways...
November 1, 2014: Biochemical Journal
https://www.readbyqxmd.com/read/24811382/stim1-controls-neuronal-ca%C3%A2-%C3%A2-%C2%BA-signaling-mglur1-dependent-synaptic-transmission-and-cerebellar-motor-behavior
#11
Jana Hartmann, Rosa M Karl, Ryan P D Alexander, Helmuth Adelsberger, Monika S Brill, Charlotta Rühlmann, Anna Ansel, Kenji Sakimura, Yoshihiro Baba, Tomohiro Kurosaki, Thomas Misgeld, Arthur Konnerth
In central mammalian neurons, activation of metabotropic glutamate receptor type1 (mGluR1) evokes a complex synaptic response consisting of IP3 receptor-dependent Ca(2+) release from internal Ca(2+) stores and a slow depolarizing potential involving TRPC3 channels. It is largely unclear how mGluR1 is linked to its downstream effectors. Here, we explored the role of stromal interaction molecule 1 (STIM1) in regulating neuronal Ca(2+) signaling and mGluR1-dependent synaptic transmission. By analyzing mouse cerebellar Purkinje neurons, we demonstrate that STIM1 is an essential regulator of the Ca(2+) level in neuronal endoplasmic reticulum Ca(2+) stores...
May 7, 2014: Neuron
https://www.readbyqxmd.com/read/24756704/trpc4-and-trpc4-containing-channels
#12
REVIEW
Marc Freichel, Volodymyr Tsvilovskyy, Juan E Camacho-Londoño
TRPC4 proteins comprise six transmembrane domains, a putative pore-forming region, and an intracellularly located amino- and carboxy-terminus. Among eleven splice variants identified so far, TRPC4α and TRPC4β are the most abundantly expressed and functionally characterized. TRPC4 is expressed in various organs and cell types including the soma and dendrites of numerous types of neurons; the cardiovascular system including endothelial, smooth muscle, and cardiac cells; myometrial and skeletal muscle cells; kidney; and immune cells such as mast cells...
2014: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/24464579/molecular-determinants-mediating-gating-of-transient-receptor-potential-canonical-trpc-channels-by-stromal-interaction-molecule-1-stim1
#13
Kyu Pil Lee, Seok Choi, Jeong Hee Hong, Malini Ahuja, Sarabeth Graham, Rong Ma, Insuk So, Dong Min Shin, Shmuel Muallem, Joseph P Yuan
Transient receptor potential canonical (TRPC) channels mediate a critical part of the receptor-evoked Ca(2+) influx. TRPCs are gated open by the endoplasmic reticulum Ca(2+) sensor STIM1. Here we asked which stromal interaction molecule 1 (STIM1) and TRPC domains mediate the interaction between them and how this interaction is used to open the channels. We report that the STIM1 Orai1-activating region domain of STIM1 interacts with the TRPC channel coiled coil domains (CCDs) and that this interaction is essential for opening the channels by STIM1...
March 7, 2014: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/23899746/trpc3-regulates-release-of-brain-derived-neurotrophic-factor-from-human-airway-smooth-muscle
#14
Pawan K Vohra, Michael A Thompson, Venkatachalem Sathish, Alexander Kiel, Calvin Jerde, Christina M Pabelick, Brij B Singh, Y S Prakash
Exogenous brain-derived neurotrophic factor (BDNF) enhances Ca(2+) signaling and cell proliferation in human airway smooth muscle (ASM), especially with inflammation. Human ASM also expresses BDNF, raising the potential for autocrine/paracrine effects. The mechanisms by which ASM BDNF secretion occurs are not known. Transient receptor potential channels (TRPCs) regulate a variety of intracellular processes including store-operated Ca(2+) entry (SOCE; including in ASM) and secretion of factors such as cytokines...
December 2013: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/23890115/contribution-and-regulation-of-trpc-channels-in-store-operated-ca2-entry
#15
REVIEW
Kwong Tai Cheng, Hwei Ling Ong, Xibao Liu, Indu S Ambudkar
Store-operated calcium entry (SOCE) is activated in response to depletion of the endoplasmic reticulum-Ca(2+) stores following stimulation of plasma membrane receptors that couple to PIP2 hydrolysis and IP3 generation. Search for the molecular components of SOCE channels led to the identification of mammalian transient receptor potential canonical (TRPC) family of calcium-permeable channels (TRPC1-TRPC7), which are all activated in response to stimuli that result in PIP2 hydrolysis. While several TRPCs, including TRPC1, TRPC3, and TRPC4, have been implicated in SOCE, the data are most consistent for TRPC1...
2013: Current Topics in Membranes
https://www.readbyqxmd.com/read/23542055/potential-contribution-of-socc-to-cerebral-vasospasm-after-experimental-subarachnoid-hemorrhage-in-rats
#16
Jin-Ning Song, Wen-Tao Yan, Ji-Yang An, Guang-Shan Hao, Xiao-Ye Guo, Ming Zhang, Yu Li, Dan-Dong Li, Peng Sun
Cerebral vasospasm (CVS) is the most treatable component of subarachnoid hemorrhage (SAH), which can be reduced by endothelin receptor antagonists. Endothelin-evoked vasospasm is considered to be mediated by Ca(2+) influx in the smooth muscle through voltage-dependent Ca(2+) channel (VDCC) and nonselective cation channels (NSCC). Because VDCC antagonists such as nimodipine have been shown to be relatively less effective than the endothelin receptor antagonists, it is assumed that NSCC maybe a more important component in mediating Ca(2+) influx during CVS...
June 23, 2013: Brain Research
https://www.readbyqxmd.com/read/23159934/nonspecific-sarcolemmal-cation-channels-are-critical-for-the-pathogenesis-of-malignant-hyperthermia
#17
José M Eltit, Xudong Ding, Isaac N Pessah, Paul D Allen, José R Lopez
Malignant hyperthermia (MH) susceptibility has been attributed to a leaky sarcoplasmic reticulum (SR) caused by missense mutations in RYR1 or CACNA1S, and the MH crisis has been attributed solely to massive self-sustaining release of Ca(2+) from SR stores elicited by triggering agents. Here, we show in muscle cells from MH-RyR1(R163C) knock-in mice that increased passive SR Ca(2+) leak causes an enlarged basal influx of sarcolemmal Ca(2+) that results in chronically elevated myoplasmic free Ca(2+) concentration ([Ca(2+)]i) at rest...
March 2013: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/23068106/different-binding-property-of-stim1-and-its-novel-splice-variant-stim1l-to-orai1-trpc3-and-trpc6-channels
#18
Takahiro Horinouchi, Tsunehito Higashi, Tsunaki Higa, Koji Terada, Yosuke Mai, Hiroyuki Aoyagi, Chizuru Hatate, Prabha Nepal, Mika Horiguchi, Takuya Harada, Soichi Miwa
Stromal interaction molecule 1 (STIM1) is the endoplasmic reticulum (ER) Ca(2+) sensor to control ER Ca(2+) levels. A recent study has shown that STIM1L, a new splice variant of STIM1, is expressed in various tissues of rodent and in human skeletal muscle, and that the interaction of STIM1L with actin filament allows rapid activation of store-operated Ca(2+) entry (SOCE) mediated through Orai1 channels. Here, we characterize mRNA expression and function of human STIM1 and STIM1L, and compare their binding property to Orai1 functioning as store-operated Ca(2+) channels (SOCCs), and TRPC3 (transient receptor potential canonical 3) and TRPC6 channels functioning as endothelin type A receptor (ET(A)R)-operated Ca(2+) channels (ROCCs)...
November 16, 2012: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/22640869/capacitative-and-non-capacitative-signaling-complexes-in-human-platelets
#19
Alejandro Berna-Erro, Carmen Galan, Natalia Dionisio, Luis J Gomez, Gines M Salido, Juan A Rosado
Discharge of the intracellular Ca(2+) stores activates Ca(2+) entry through store-operated channels (SOCs). Since the recent identification of STIM1 and STIM2, as well as the Orai1 homologs, Orai2 and Orai3, the protein complexes involved in Ca(2+) signaling needs re-evaluation in native cells. Using real time PCR combined with Western blotting we have found the expression of the three Orai isoforms, STIM1, STIM2 and different TRPCs in human platelets. Depletion of the intracellular Ca(2+) stores with thapsigargin, independently of changes in cytosolic Ca(2+) concentration, enhanced the formation of a signaling complex involving STIM1, STIM2, Orai1, Orai2 and TRPC1...
August 2012: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/22203682/transient-receptor-potential-canonical-channels-are-required-for-in-vitro-endothelial-tube-formation
#20
Fabrice Antigny, Nathalie Girardin, Maud Frieden
In endothelial cells Ca(2+) entry is an essential component of the Ca(2+) signal that takes place during processes such as cell proliferation or angiogenesis. Ca(2+) influx occurs via the store-operated Ca(2+) entry pathway, involving stromal interaction molecule-1 (STIM1) and Orai1, but also through channels gated by second messengers like the transient receptor potential canonical (TRPC) channels. The human umbilical vein-derived endothelial cell line EA.hy926 expressed STIM1 and Orai1 as well as several TRPC channels...
February 17, 2012: Journal of Biological Chemistry
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