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https://www.readbyqxmd.com/read/27902848/topiramate-in-migraine-prevention-a-2016-perspective
#1
Stephen D Silberstein
BACKGROUND: In evidence-based guidelines published in 2000, topiramate was a third-tier migraine preventive with no scientific evidence of efficacy; recommendation for its use reflected consensus opinion and clinical experience. Its neurostabilizing activity, coupled with its favorable weight profile, made topiramate an attractive alternative to other migraine preventives that caused weight gain. When guidelines for migraine prevention in episodic migraine were published in 2012, topiramate was included as a first-line option based on double-blind, randomized controlled trials involving nearly 3000 patients...
November 30, 2016: Headache
https://www.readbyqxmd.com/read/27900193/exertional-rhabdomyolysis-physiological-response-or-manifestation-of-an-underlying-myopathy
#2
Renata S Scalco, Marc Snoeck, Ros Quinlivan, Susan Treves, Pascal Laforét, Heinz Jungbluth, Nicol C Voermans
Exertional rhabdomyolysis is characterised by muscle breakdown associated with strenuous exercise or normal exercise under extreme circumstances. Key features are severe muscle pain and sudden transient elevation of serum creatine kinase (CK) levels with or without associated myoglobinuria. Mild cases may remain unnoticed or undiagnosed. Exertional rhabdomyolysis is well described among athletes and military personnel, but may occur in anybody exposed to unaccustomed exercise. In contrast, exertional rhabdomyolysis may be the first manifestation of a genetic muscle disease that lowers the exercise threshold for developing muscle breakdown...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27900169/neuromuscular-exercise-and-back-counselling-for-female-nursing-personnel-with-recurrent-non-specific-low-back-pain-study-protocol-of-a-randomised-controlled-trial-nurse-rct
#3
Jaana H Suni, Marjo Rinne, Markku Kankaanpää, Annika Taulaniemi, Sirpa Lusa, Harri Lindholm, Jari Parkkari
INTRODUCTION: Nursing personnel have high risk for incidence of low back pain (LBP) followed by development of chronic pain and disability. Multiple risk factors such as patient handling, night shift work and lack of supporting work culture have been identified. In subacute LBP, high-fear avoidance is prognostic for more pain, disability and not returning to work. Lack of leisure-time physical activity predicts long-term sickness absence. The purpose of this study is to compare effectiveness of 6-month neuromuscular exercise and counselling in treating back pain in female nursing personnel with recurrent non-specific LBP pain compared with either (exercise or counselling) alone and a non-treatment control group...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27893033/effect-of-a-decision-aid-on-access-to-total-knee-replacement-for-black-patients-with-osteoarthritis-of-the-knee-a-randomized-clinical-trial
#4
Said A Ibrahim, Marissa Blum, Gwo-Chin Lee, Pekka Mooar, Elina Medvedeva, Aliya Collier, Diane Richardson
Importance: Black patients with advanced osteoarthritis (OA) of the knee are significantly less likely than white patients to undergo surgery. No strategies have been proved to improve access to surgery for black patients with end-stage OA of the knee. Objective: To assess whether a decision aid improves access to total knee replacement (TKR) surgery for black patients with OA of the knee. Design, Setting, and Participants: In a randomized clinical trial, 336 eligible participants who self-identified as black and 50 years or older with chronic and frequent knee pain, a Western Ontario McMaster Universities Osteoarthritis Index score of at least 39, and radiographic evidence of OA of the knee were recruited from December 1, 2010, to May 31, 2014, at 3 medical centers...
November 23, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27886697/nonsurgical-management-of-osteoarthritis-knee-pain-in-the-older-adult
#5
REVIEW
Nora Taylor
Symptomatic knee osteoarthritis is a common complaint of many elderly patients in primary care offices. For those unable or unwilling to undergo knee replacement, the primary practitioners' understanding of the strengths and weaknesses of the available treatment modalities for pain relief is critical to successful in-office counseling and expectation management. Treatment requires a multimodal approach of nonpharmacologic and pharmacologic therapies to achieve a maximal clinical benefit. The focus of this review is on the nonsurgical options for treatment of knee osteoarthritis in patients aged 65 and older...
February 2017: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/27873040/can-mri-predict-meningioma-consistency-a-correlation-with-tumor-pathology-and-systematic-review
#6
REVIEW
Amy Yao, Margaret Pain, Priti Balchandani, Raj K Shrivastava
Tumor consistency is a critical factor that influences operative strategy and patient counseling. Magnetic resonance imaging (MRI) describes the concentration of water within living tissues and as such, is hypothesized to predict aspects of their biomechanical behavior. In meningiomas, MRI signal intensity has been used to predict the consistency of the tumor and its histopathological subtype, though its predictive capacity is debated in the literature. We performed a systematic review of the PubMed database since 1990 concerning MRI appearance and tumor consistency to assess whether or not MRI can be used reliably to predict tumor firmness...
November 21, 2016: Neurosurgical Review
https://www.readbyqxmd.com/read/27867440/an-unusual-case-of-a-metallic-foreign-body-per-urethra
#7
Haresh G Thummar, Hemen I Vithlani, Pokhraj P Suthar, Deepa Regina John, Nisha Thummar, Harendra Chauhan
BACKGROUND: Foreign body in the lower urinary tract has a low incidence. Here we discuss a case of a safety pin within the bulbar urethra inserted by a young boy for sexual gratification, which was successfully removed under cysto-urethroscopic guidance. CASE REPORT: Herein we present a case of a 14-year-old boy who presented with complaints of perineal pain and dysuria. On evaluation in detail and from clinical history, we came to know that he had inserted a safety pin within the urethra...
2016: Polish Journal of Radiology
https://www.readbyqxmd.com/read/27853167/what-kind-of-sexual-dysfunction-is-most-common-among-overweight-and-obese-women-in-reproductive-age
#8
S Rabiepoor, H R Khalkhali, E Sadeghi
The aim of this study was to investigate the association between body mass index (BMI) and sexual health and determine what kind of sexual dysfunction is most common among overweight and obese women in reproductive age from Iran. A cross-sectional descriptive design was adopted. The data of 198 women who referred to health centers during 2014-2015 in Iran were collected through convenient sampling. Data were collected using a demographic questionnaire, female sexual function and sexual satisfaction indexes...
November 17, 2016: International Journal of Impotence Research
https://www.readbyqxmd.com/read/27852908/final-fusion-after-growing-rod-treatment-for-early-onset-scoliosis-is-it-really-final
#9
Connie Poe-Kochert, Claire Shannon, Jeff B Pawelek, George H Thompson, Christina K Hardesty, David S Marks, Behrooz A Akbarnia, Richard E McCarthy, John B Emans
BACKGROUND: Final fusion is thought to be the end point for patients with early onset scoliosis following treatment with the use of growing rods. But is it? The purpose of this study was to determine the incidence and cause of any reoperation after final fusion. METHODS: A multicenter database of patients with early onset scoliosis was retrospectively analyzed to identify patients treated with growing rods with a minimum of 2 years of follow-up after final fusion...
November 16, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27851662/improvement-in-srs22r-pain-scores-after-surgery-for-adolescent-idiopathic-scoliosis
#10
Mladen Djurasovic, Steven D Glassman, Daniel J Sucato, Lawrence G Lenke, Charles H Crawford, Leah Y Carreon
STUDY DESIGN: Longitudinal cohort. OBJECTIVE: To investigate whether patients with painful adolescent idiopathic scoliosis experience pain relief with surgical treatment. SUMMARY OF BACKGROUND DATA: Adolescent idiopathic scoliosis (AIS) was previously thought to be a painless condition, but recent studies have shown that a significant proportion of patients have pain. Little information is available regarding pain relief with surgical treatment for AIS...
November 15, 2016: Spine
https://www.readbyqxmd.com/read/27848054/incidence-and-predictive-risk-factors-of-postoperative-sepsis-in-orthopedic-trauma-patients
#11
Nikita Lakomkin, Vasanth Sathiyakumar, Brandon Wick, Michelle S Shen, A Alex Jahangir, Hassan Mir, William T Obremskey, Ashley C Dodd, Manish K Sethi
BACKGROUND: Postoperative sepsis is associated with high mortality and the national costs of septicemia exceed those of any other diagnosis. While numerous studies in the basic orthopedic science literature suggest that traumatic injuries facilitate the development of sepsis, it is currently unclear whether orthopedic trauma patients are at increased risk. The purpose of this study was thus to assess the incidence of sepsis and determine the risk factors that significantly predicted septicemia following orthopedic trauma surgery...
November 15, 2016: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/27831524/predictors-of-depression-among-adult-women-with-diabetes-in-the-united-states-an-analysis-using-national-health-and-nutrition-examination-survey-data-from-2007-to-2012
#12
Shiela M Strauss, Mary T Rosedale, David M Rindskopf
PURPOSE: The purpose of the study was to identify the sex-specific characteristics that predict depression among adult women with diabetes. METHODS: Data from the 2007-2012 National Health and Nutrition Examination Survey in the United States were used to identify the predictors of depression in a large sample of women ages 20 years and older with diabetes (n = 946). RESULTS: When extrapolated to almost 9 million women in the United States ≥ 20 years of age with diabetes, 19...
December 2016: Diabetes Educator
https://www.readbyqxmd.com/read/27829449/efficacy-of-brief-behavioral-counselling-by-allied-health-professionals-to-promote-physical-activity-in-people-with-peripheral-arterial-disease-bipp-study-protocol-for-a-multi-center-randomized-controlled-trial
#13
Nicola W Burton, Zanfina Ademi, Stuart Best, Maria A Fiatarone Singh, Jason S Jenkins, Kenny D Lawson, Anthony S Leicht, Yorgi Mavros, Yian Noble, Paul Norman, Richard Norman, Belinda J Parmenter, Jenna Pinchbeck, Christopher M Reid, Sophie E Rowbotham, Lisan Yip, Jonathan Golledge
BACKGROUND: Physical activity is recommended for people with peripheral arterial disease (PAD), and can improve walking capacity and quality of life; and reduce pain, requirement for surgery and cardiovascular events. This trial will assess the efficacy of a brief behavioral counselling intervention delivered by allied health professionals to improve physical activity in people with PAD. METHODS: This is a multi-center randomised controlled trial in four cities across Australia...
November 9, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27829064/acceptability-study-on-hiv-self-testing-among-transgender-women-men-who-have-sex-with-men-and-female-entertainment-workers-in-cambodia-a-qualitative-analysis
#14
Khuondyla Pal, Chanrith Ngin, Sovannary Tuot, Pheak Chhoun, Cheaty Ly, Srean Chhim, Minh-Anh Luong, Brent Tatomir, Siyan Yi
BACKGROUND: In Cambodia, HIV prevalence is high while HIV testing rates remain low among transgender women (TG women), men who have sex with men (MSM), and female entertainment workers (FEW). Introducing self-testing for HIV to these key populations (KPs) could potentially overcome the under-diagnosis of HIV and significantly increase testing rates and receipt of the results, and thus could decrease transmission. Therefore, this study aimed to determine the acceptability of HIV self-testing (HIVST) among these three categories of KPs...
2016: PloS One
https://www.readbyqxmd.com/read/27826760/myotonic-dystrophy-type-1-management-and-therapeutics
#15
REVIEW
Cheryl A Smith, Laurie Gutmann
Myotonic dystrophy (DM1) is the most common form of adult muscular dystrophy. It is a multisystem disorder with a complex pathophysiology. Although inheritance is autosomal dominant, disease variability is attributed to anticipation, a maternal expansion bias, variable penetrance, somatic mosaicism, and a multitude of aberrant pre-mRNA splicing events. Patient presentations range from asymptomatic or mild late onset adult to severe congenital forms. Multiple organ systems may be affected. Patients may experience early cataracts, myotonia, muscle weakness/atrophy, fatigue, excessive daytime sleepiness, central/obstructive apnea, respiratory failure, cardiac arrhythmia, insulin resistance, dysphagia, GI dysmotility, cognitive impairment, Cluster C personality traits, and/or mood disorders...
December 2016: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/27825327/treatment-of-trauma-affected-refugees-with-venlafaxine-versus-sertraline-combined-with-psychotherapy-a-randomised-study
#16
Charlotte Sonne, Jessica Carlsson, Per Bech, Ask Elklit, Erik Lykke Mortensen
BACKGROUND: The prevalence of trauma-related psychiatric disorders is high among refugees. Despite this, little is known about the effect of pharmacological treatment for this patient group. The objective of the present study was therefore to examine differences in the effects of venlafaxine and sertraline on Post-Traumatic Stress Disorder (PTSD), depression and functional impairment in trauma-affected refugees. METHODS: The study was a randomised pragmatic trial comparing venlafaxine and sertraline in combination with psychotherapy and social counselling...
November 8, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27803562/perspective-of-orthopedists-on-pain-management-in-osteoarthritis-a-qualitative-study
#17
Jose Austine, Shoba Nair, Kiyana Mirza
CONTEXT: Osteoarthritis (OA) is a degenerative disorder characterized by pain, stiffness, and loss of mobility of the joint. As the most prevalent form of arthritis and a leading cause of impairment, it is imperative to understand the treating doctor's perception of pain relief among these patients. OBJECTIVES: To assess orthopedists' perspectives on pain management in OA. MATERIALS AND METHODS: In this qualitative study, a guide-based interview was conducted on 15 orthopedists of a tertiary care hospital and audio-recorded simultaneously...
October 2016: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/27797879/infant-born-with-robert-s-syndrome-without-prenatal-care-in-a-developing-nation
#18
Denise Benardete, Neeraja Chandrasekaran, Lisa Cariello, Diego Meraz
Maternal and child well-being during pregnancy can be attributed to receiving optimal prenatal care. However, in developing nations, there are many barriers to receiving this. We present a primigravid female aged 29 years with severe abdominal pain. She was in active labour at 40 weeks and completely unaware of her pregnancy; hence, she did not receive any prenatal care. The baby was born with significant birth deformities that were consistent with Robert's syndrome. Although early detection could not preclude the development of this disorder, proper care would have facilitated in receiving genetic counselling and proper understanding of the prognosis...
October 25, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27796772/health-related-quality-of-life-factors-associated-with-completion-of-a-study-delivering-lifestyle-exercise-intervention-for-endometrial-cancer-survivors
#19
Jaejoon Song, Melissa Karlsten, José-Miguel Yamal, Karen Basen-Engquist
PURPOSE: The aim of this study was to examine associations between participants' quality of life and study completion. This is a secondary analysis of an exercise intervention study for endometrial cancer survivors. METHODS: We considered data for one-hundred post-treatment endometrial cancer survivors from a single-arm, six-month longitudinal exercise study. Participants received a home-based intervention consisting of exercise recommendations and telephone counseling sessions to encourage adherence...
October 31, 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27783781/fatherhood-experiences-of-fathers-of-boys-diagnosed-with-duchenne-muscular-dystrophy
#20
Silvana Aparecida de Lucca, Eucia Beatriz Lopes Petean
This study's aim was to understand the experience of being the father of a boy diagnosed with Duchenne Muscular Dystrophy (DMD). Eight fathers of 10-year-old or older boys diagnosed with DMD, living in RibeirãoPreto and surrounding cities participated in the study. Interviews included a semi-structured script and data were analyzed according to thematic content analysis. The results show that the confirmation of a DMD diagnosis shocked fathers and was mixed with sorrow, helplessness and hopelessness. Most fathers considered the illness of their child to be a mission sent by God, which helps to alleviate the pain and anguish caused by the disease...
October 2016: Ciência & Saúde Coletiva
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