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CCL11

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https://www.readbyqxmd.com/read/28634890/ccl11-eotaxin-1-levels-predict-long-term-functional-outcomes-in-patients-following-ischemic-stroke
#1
Meaghan Roy-O'Reilly, Rodney M Ritzel, Sarah E Conway, Ilene Staff, Gilbert Fortunato, Louise D McCullough
Circulating levels of the pro-inflammatory cytokine C-C motif chemokine 11 (CCL11, also known as eotaxin-1) are increased in several animal models of neuroinflammation, including traumatic brain injury and Alzheimer's disease. Increased levels of CCL11 have also been linked to decreased neurogenesis in mice. We hypothesized that circulating CCL11 levels would increase following ischemic stroke in mice and humans, and that higher CCL11 levels would correlate with poor long-term recovery in patients. As predicted, circulating levels of CCL11 in both young and aged mice increased significantly 24 h after experimental stroke...
June 21, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28628884/proteomics-profiling-reveals-inflammatory-biomarkers-of-antidepressant-treatment-response-findings-from-the-co-med-trial
#2
Bharathi S Gadad, Manish K Jha, Bruce D Grannemann, Taryn L Mayes, Madhukar H Trivedi
Animal and human studies suggest an association between depression and aberrant immune response. Further, common inflammatory markers may change during the course of antidepressant treatment in patients. The objective of this study was to evaluate changes in inflammatory markers and clinical outcomes from subjects enrolled in the Combining Medications to Enhance Depression Outcome (CO-MED) trial. At baseline and week 12 (treatment completion), plasma samples of 102 participants were analyzed via a multiplex assay comprised of inflammatory markers using a 27-plex standard assay panel plus a 4-plex human acute phase xMAP technology based platform...
May 26, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28583232/effect-of-topical-beclomethasone-on-inflammatory-markers-in-adults-with-eosinophilic-esophagitis-a-pilot-study
#3
Neeti Bhardwaj, Faoud Ishmael, Erik Lehman, Deborah Bethards, Francesca Ruggiero, Gisoo Ghaffari
BACKGROUND: Topical corticosteroids have proven efficacy in the treatment of eosinophilic esophagitis (EoE) and are considered the cornerstone of therapy. OBJECTIVE: To evaluate the effect of topical beclomethasone dipropionate (BDP) therapy on clinical outcomes, esophageal eosinophilia, and other markers of inflammation in patients with EoE. METHODS: Nine subjects with a biopsy-proven diagnosis of EoE were enrolled. In a cross-over design, the subjects were randomly assigned to a sequence of BDP and placebo...
June 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/28572801/elevated-levels-of-proinflammatory-cytokines-in-cerebrospinal-fluid-of-multiple-sclerosis-patients
#4
Timur Khaibullin, Vilena Ivanova, Ekaterina Martynova, Georgy Cherepnev, Farit Khabirov, Evgenii Granatov, Albert Rizvanov, Svetlana Khaiboullina
Multiple sclerosis (MS) is an autoimmune neurodegenerative disease characterized by chronic brain inflammation. Leukocyte infiltration of brain tissue causes inflammation, demyelination, and the subsequent formation of sclerotic plaques, which are a hallmark of MS. Activation of proinflammatory cytokines is essential for regulation of lymphocyte migration across the blood-brain barrier. We demonstrate increased levels of many cytokines, including IL-2RA, CCL5, CCL11, MIF, CXCL1, CXCL10, IFNγ, SCF, and TRAIL, were upregulated in cerebrospinal fluid (CSF), whereas IL-17, CCL2, CCL3, CCL4, and IL-12(p40) were activated in MS serum...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28569792/loss-of-epidermal-ap1-transcription-factor-function-reduces-filaggrin-level-alters-chemokine-expression-and-produces-an-ichthyosis-related-phenotype
#5
Christina A Young, Ellen A Rorke, Gautam Adhikary, Wen Xu, Richard L Eckert
AP1 transcription factors are important controllers of epidermal differentiation. Multiple family members are expressed in the epidermis in a differentiation-dependent manner, where they function to regulate gene expression. To study the role of AP1 factor signaling, TAM67 (dominant-negative c-jun) was inducibly expressed in the suprabasal epidermis. The TAM67-positive epidermis displays keratinocyte hyperproliferation, hyperkeratosis and parakeratosis, delayed differentiation, extensive subdermal vasodilation, nuclear loricrin localization, tail and digit pseudoainhum and reduced filaggrin level...
June 1, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28537901/inflammatory-cytokines-are-associated-with-response-and-prognosis-in-patients-with-esophageal-cancer
#6
Susanne Blank, Henrik Nienhüser, Lena Dreikhausen, Leila Sisic, Ulrike Heger, Katja Ott, Thomas Schmidt
BACKGROUND: Esophageal cancer is often marked by aggressive tumor growth and poor prognosis. Patient groups who benefit from perioperative therapy are not yet defined. The tumor microenvironment and circulating factors as possible predictors of response and prognosis gain interest. This study aimed to investigate cytokines in patients' serum and tumor tissue with regard to response and prognosis. RESULTS: Median survival between SCC and AC was not different (published previously)...
May 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28512644/analysis-of-serum-cytokines-and-single-nucleotide-polymorphisms-of-sod1-sod2-and-cat-in-erysipelas-patients
#7
Charles C Emene, Irina E Kravchenko, Gulnaz I Aibatova, Albert A Rizvanov
Increased free radical production had been documented in group A (β-hemolytic) streptococcus infection cases. Comparing 71 erysipelas patients to 55 age-matched healthy individuals, we sought for CAT, SOD1, and SOD2 single polymorphism mutation (SNPs) interactions with erysipelas' predisposition and serum cytokine levels in the acute and recovery phases of erysipelas infection. Whereas female patients had a higher predisposition to erysipelas, male patients were prone to having a facial localization of the infection...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28489854/functional-and-phenotypic-evaluation-of-eosinophils-from-patients-with-the-acute-form-of-paracoccidioidomycosis
#8
Fernanda Gambogi Braga, Luciana Pereira Ruas, Ricardo Mendes Pereira, Xinaida Taligare Lima, Edson Antunes, Ronei Luciano Mamoni, Maria Heloisa Souza Lima Blotta
BACKGROUND: Eosinophilia is a typical finding of the acute/juvenile form of paracoccidioidomycosis (PCM), a systemic mycosis endemic in Latin America. This clinical form is characterized by depressed cellular immune response and production of Th2 cytokines. Moreover, it has been shown that the increased number of eosinophils in peripheral blood of patients returns to normal values after antifungal treatment. However, the role of eosinophils in PCM has never been evaluated. This study aimed to assess the phenotypic and functional characteristics of eosinophils in PCM...
May 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28487742/serum-cytokine-profile-in-a-patient-diagnosed-with-dysferlinopathy
#9
Svetlana F Khaiboullina, Ekaterina V Martynova, Sergey N Bardakov, Mikhail O Mavlikeev, Ivan A Yakovlev, Arthur A Isaev, Roman V Deev, Albert A Rizvanov
Limb-girdle muscular dystrophy type 2 (LGMD2B) is a mild form of dysferlinopathy, characterized by limb weakness and wasting. It is an autosomal recessive disease, with currently 140 mutations in the LGMD2B gene identified. Lack of functional dysferlin inhibits muscle fiber regeneration in voluntary muscles, the main pathological finding in LGMD2B patients. However, the immune system has been suggested to contribute to muscle cell death and tissue regeneration. Serum levels of 27 cytokines were evaluated in a dysferlinopathy patient...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28475193/metabolomic-profiling-and-biochemical-evaluation-of-the-follicular-fluid-of-endometriosis-patients
#10
Santonastaso Marianna, Pucciarelli Alessia, Costantini Susan, Caprio Francesca, Sorice Angela, Capone Francesca, Natella Antonella, Iardino Patrizia, Colacurci Nicola, Chiosi Emilio
Diseases are complex systems that can be studied through the integration of data derived from different disciplines to obtain a global and reliable picture of the biological phenomenon under investigation. Based on the recent observations that the metabolomics profiling of follicular fluids reflects the ovarian microenvironment of women and that endometriosis represents an example of complex diseases, clearly diagnosed by laparoscopy, we thought that the follicular fluids of endometriosis patients can represent a study model to evaluate the possibility of integrating data obtained by different approaches...
June 1, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28465475/down-regulation-of-mir-29b-in-carcinoma-associated-fibroblasts-promotes-cell-growth-and-metastasis-of-breast-cancer
#11
Yonglei Liu, Jingling Zhang, Xiangjun Sun, Quanping Su, Cuiping You
Carcinoma associated fibroblasts (CAFs) play important roles in breast cancer development and progression. Recent studies show that microRNAs (miRNAs) are the main regulators in CAFs. MiR-29b is one of the significant down-regulated miRNAs in CAFs from the miRNA screening. The role of miR-29b in the interaction between CAFs and breast cancer is still unclear. In the present study, we investigated the effects of CAFs on breast cancer cell proliferation and metastasis regulated by miR-29b. We found that fibroblasts activated by co-cultured breast cancer cells produced higher levels of some chemokines like CCL11, CXCL14, which accelerated breast cancer cell growth and induced drug resistance and metastasis...
June 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28404797/self-adjuvanting-c18-lipid-vinil-sulfone-pp2a-vaccine-study-of-the-induced-immunomodulation-against-trichuris-muris-infection
#12
M Gomez-Samblas, J J García-Rodríguez, M Trelis, D Bernal, F J Lopez-Jaramillo, F Santoyo-Gonzalez, S Vilchez, A M Espino, F Bolás-Fernández, A Osuna
Despite the importance of the adjuvant in the immunization process, very few adjuvants merge with the antigens in vaccines. A synthetic self-adjuvant oleic-vinyl sulfone (OVS) linked to the catalytic region of recombinant serine/threonine phosphatase 2A from the nematode Angiostrongylus costaricensis (rPP2A) was used for intranasal immunization in mice previously infected with Trichuris muris The animal intranasal immunization with rPP2A-OVS showed a reduction of 99.01% in the number of the nematode eggs and 97...
April 2017: Open Biology
https://www.readbyqxmd.com/read/28396851/increased-circulatory-levels-of-fractalkine-cx3cl1-are-associated-with-inflammatory-chemokines-and-cytokines-in-individuals-with-type-2-diabetes
#13
Sardar Sindhu, Nadeem Akhter, Hossein Arefanian, Areej Abu Al-Roub, Shamsha Ali, Ajit Wilson, Asma Al-Hubail, Shaima Al-Beloushi, Saad Al-Zanki, Rasheed Ahmad
BACKGROUND: Fractalkine (CX3CL1) is involved in the development of numerous inflammatory conditions including metabolic diseases. However, changes in the circulatory fractalkine levels in type-2 diabetes (T2D) and their relationship with inflammatory chemokines/cytokines remain unclear. The aim of the study was to determine the T2D-associated modulations in plasma fractalkine levels and investigate their relationship with circulatory chemokines/cytokines. METHODS: A total of 47 plasma samples were collected from 23 T2D and 24 non-diabetic individuals selected over a wide range of body mass index (BMI)...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/28393456/blackcurrant-anthocyanins-modulate-ccl11-secretion-and-suppress-allergic-airway-inflammation
#14
Odette M Shaw, Tafadzwa Nyanhanda, Tony K McGhie, Jacquie L Harper, Roger D Hurst
CCL11, a chemokine, is linked to the early development of airways eosinophilia in allergic asthma. Therefore, CCL11 production is a target for abrogating eosinophilic-driven airway inflammation. Blackcurrants are high in compounds that regulate inflammation, particularly anthocyanins. In this study, we investigated the effect of oral blackcurrant supplementation on allergen-induced eosinophilia and CCL11 production; we also profiled key compounds in blackcurrants that were linked to this effect. Ten milligram per kilogram (total anthocyanins) of a commercially available, anthocyanin-rich New Zealand "Ben Ard" blackcurrant extract ("Currantex 30") attenuated ovalbumin-induced inflammation, eosinophilia (by 52...
April 9, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28375674/the-inflammatory-cxc-chemokines-gro%C3%AE-high-ip-10-low-and-mig-low-in-tumor-microenvironment-can-be-used-as-new-indicators-for-non-small-cell-lung-cancer-progression
#15
Ya Cao, Haitao Huang, Zhenxin Wang, Guangbo Zhang
AIMS: To investigate the clinical significance of tumor tissue-infiltrating chemokines expression in non-small cell lung cancer (NSCLC) microenvironment. MATERIALS AND METHODS: Fresh tissue samples were acquired from 50 patients with NSCLC after operation. Then, we quantified the total protein with the BCA Protein Assay Kit and tested 13 chemotactic factors in paired samples including tumor tissues, tumor adjacent tissues, and normal tissues with the CBA Kit. RESULTS: We found that the chemokine CC subfamily of MCP-1, MIP-1α, MIP-1β, and MIP-3α and the chemokine CXC subfamily of IL-8, GROα, IP-10, and MIG expressions in tumor tissues were significantly higher than those in tumor-adjacent tissues and normal tissues...
April 4, 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28373098/a-comprehensive-evaluation-of-nasal-and-bronchial-cytokines-and-chemokines-following-experimental-rhinovirus-infection-in-allergic-asthma-increased-interferons-ifn-%C3%AE-and-ifn-%C3%AE-and-type-2-inflammation-il-5-and-il-13
#16
Trevor T Hansel, Tanushree Tunstall, Maria-Belen Trujillo-Torralbo, Betty Shamji, Ajerico Del-Rosario, Jaideep Dhariwal, Paul D W Kirk, Michael P H Stumpf, Jens Koopmann, Aurica Telcian, Julia Aniscenko, Leila Gogsadze, Eteri Bakhsoliani, Luminita Stanciu, Nathan Bartlett, Michael Edwards, Ross Walton, Patrick Mallia, Toby M Hunt, Trevor L Hunt, Duncan G Hunt, John Westwick, Matthew Edwards, Onn Min Kon, David J Jackson, Sebastian L Johnston
BACKGROUND: Rhinovirus infection is a major cause of asthma exacerbations. OBJECTIVES: We studied nasal and bronchial mucosal inflammatory responses during experimental rhinovirus-induced asthma exacerbations. METHODS: We used nasosorption on days 0, 2-5 and 7 and bronchosorption at baseline and day 4 to sample mucosal lining fluid to investigate airway mucosal responses to rhinovirus infection in patients with allergic asthma (n=28) and healthy non-atopic controls (n=11), by using a synthetic absorptive matrix and measuring levels of 34 cytokines and chemokines using a sensitive multiplex assay...
May 2017: EBioMedicine
https://www.readbyqxmd.com/read/28362325/possible-roles-of-cc-and-cxc-chemokines-in-regulating-bovine-endometrial-function-during-early-pregnancy
#17
Ryosuke Sakumoto, Ken-Go Hayashi, Shiori Fujii, Hiroko Kanahara, Misa Hosoe, Tadashi Furusawa, Keiichiro Kizaki
The aim of the present study was to determine the possible roles of chemokines in regulating bovine endometrial function during early pregnancy. The expression of six chemokines, including CCL2, CCL8, CCL11, CCL14, CCL16, and CXCL10, was higher in the endometrium at 15 and 18 days of pregnancy than at the same days in non-pregnant animals. Immunohistochemical staining showed that chemokine receptors (CCR1, CCR2, CCR3, and CXCR3) were expressed in the epithelial cells and glandular epithelial cells of the bovine endometrium as well as in the fetal trophoblast obtained from a cow on day 18 of pregnancy...
March 31, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28342911/basophils-high-affinity-ige-receptors-and-ccl2-in-human-anaphylaxis
#18
Peter Korosec, Paul J Turner, Mira Silar, Peter Kopac, Mitja Kosnik, Bernhard F Gibbs, Mohamed H Shamji, Adnan Custovic, Matija Rijavec
BACKGROUND: The role of basophils in anaphylaxis is unclear. OBJECTIVE: We sought to investigate whether basophils have an important role in human anaphylaxis. METHODS: In an emergency department study we recruited 31 patients with acute anaphylaxis, predominantly to Hymenoptera venom. We measured expression of basophil activation markers (CD63 and CD203c); the absolute number of circulating basophils; whole-blood FCER1A, carboxypeptidase A3 (CPA3), and L-histidine decarboxylase (HDC) gene expression; and serum markers (CCL2, CCL5, CCL11, IL-3, and thymic stromal lymphopoietin) at 3 time points (ie, during the anaphylactic episode and in convalescent samples 7 and 30 days later)...
March 22, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28338779/telomere-length-and-ccl11-levels-are-associated-with-gray-matter-volume-and-episodic-memory-performance-in-schizophrenia-evidence-of-pathological-accelerated-aging
#19
Leticia Sanguinetti Czepielewski, Raffael Massuda, Bruna Panizzutti, Lucas Kich Grun, Florencia María Barbé-Tuana, Antonio Lucio Teixeira, Deanna M Barch, Clarissa S Gama
Schizophrenia (SZ) is associated with increased somatic morbidity and mortality, in addition to cognitive impairments similar to those seen in normal aging, which may suggest that pathological accelerated aging occurs in SZ. Therefore, we aim to evaluate the relationships of age, telomere length (TL), and CCL11 (aging and inflammatory biomarkers, respectively), gray matter (GM) volume and episodic memory performance in individuals with SZ compared to healthy controls (HC). One hundred twelve participants (48 SZ and 64 HC) underwent clinical and memory assessments, structural MRI, and had their peripheral blood drawn for biomarkers analysis...
February 22, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28321152/th1-th17-related-cytokines-and-chemokines-and-their-implications-in-the-pathogenesis-of-pemphigus-vulgaris
#20
Rodolfo Pessato Timoteo, Marcos Vinicius da Silva, Camila Botelho Miguel, Djalma Alexandre Alves Silva, Jonatas Da Silva Catarino, Virmondes Rodrigues Junior, Helioswilton Sales-Campos, Carlo Jose Freire Oliveira
Pemphigus vulgaris (PV) is an autoimmune disease characterized by the presence of IgG autoantibodies against desmoglein-3. Despite the variety of findings, the chemokine and cytokine profiles that characterize the immune response in the disease are still poorly explored. Thus, 20 PV patients and 20 controls were grouped according to gender, ethnicity, place of residence, and clinical parameters of the disease. Then, the levels of chemokines and of Th1/Th2/Th17/Treg/Th9/Th22-related cytokines were assessed in the serum...
2017: Mediators of Inflammation
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