Roberta Ribeiro, Emanuele Guimarães Silva, Felipe Caixeta Moreira, Giovanni Freitas Gomes, Gabriela Reis Cussat, Barbara Stehling Ramos Silva, Maria Carolina Machado da Silva, Heliana de Barros Fernandes, Carolina de Sena Oliveira, Leonardo de Oliveira Guarnieri, Victoria Lopes, Cláudia Natália Ferreira, Ana Maria Caetano de Faria, Tatiani Uceli Maioli, Fabíola Mara Ribeiro, Aline Silva de Miranda, Grace Schenatto Pereira Moraes, Antônio Carlos Pinheiro de Oliveira, Luciene Bruno Vieira
Chronic consumption of hyperpalatable and hypercaloric foods has been pointed out as a factor associated with cognitive decline and memory impairment in obesity. In this context, the integration between peripheral and central inflammation may play a significant role in the negative effects of an obesogenic environment on memory. However, little is known about how obesity-related peripheral inflammation affects specific neurotransmission systems involved with memory regulation. Here, we test the hypothesis that chronic exposure to a highly palatable diet may cause neuroinflammation, glutamatergic dysfunction, and memory impairment...
September 29, 2023: Scientific Reports