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https://www.readbyqxmd.com/read/28923312/autophagy-its-mechanisms-and-regulation-implications-in-neurodegenerative-diseases
#1
REVIEW
Milad Moloudizargari, Mohammad Hossein Asghari, Emad Ghobadi, Marjan Fallah, Shima Rasouli, Mohammad Abdollahi
Autophagy is a major regulatory cellular mechanism which gives the cell an ability to cope with some of the destructive events that normally occur within a metabolically living cell. This is done by maintaining the cellular homeostasis, clearance of damaged organelles and proteins and recycling necessary molecules like amino acids and fatty acids. There is a wide array of factors that influence autophagy in the state of health and disease. Disruption of these mechanisms may not only give rise to several autophagy-related disease, but also it can occur as the result of intracellular changes induced during disease pathogenesis causing exacerbation of the disease...
September 15, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28922234/consensus-statement-by-the-congenital-cardiac-anesthesia-society-milestones-for-the-pediatric-cardiac-anesthesia-fellowship
#2
Viviane G Nasr, Nina A Guzzetta, Wanda C Miller-Hance, Mark Twite, Gregory J Latham, Luis Zabala, Susan C Nicolson, Emad B Mossad, James A DiNardo
Pediatric cardiac anesthesiology has evolved as a subspecialty of both pediatric and cardiac anesthesiology and is devoted to caring for individuals with congenital heart disease ranging in age from neonates to adults. Training in pediatric cardiac anesthesia is a second-year fellowship with variability in both training duration and content and is not accredited by the Accreditation Council on Graduate Medical Education. Consequently, in this article and based on the Accreditation Council on Graduate Medical Education Milestones Model, an expert panel of the Congenital Cardiac Anesthesia Society, a section of the Society of Pediatric Anesthesiology, defines 18 milestones as competency-based developmental outcomes for training in the pediatric cardiac anesthesia fellowship...
September 14, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28920703/prognostic-usefulness-of-an-age-adapted-equation-for-renal-function-assessment-in-older-patients-with-acute-coronary-syndrome
#3
Lucía Rioboo Lestón, Emad Abu-Assi, Sergio Raposeiras-Roubin, Rafael Cobas-Paz, Berenice Caneiro-Queija, Jose Manuel Rodríguez-Rodríguez, Andres Íñiguez-Romo
BACKGROUND: Renal dysfunction negatively impacts survival in acute coronary syndrome patients. The Berlin Initiative Study creatinine-based (BIScrea) equation has recently been proposed for renal function assessment in older persons. However, up to now it is unknown if the superiority of the new BIScrea equation, with respect to the most recommended chronic kidney disease epidemiology collaboration creatinine-based (CKD-EPIcrea) formula, would translate into better risk prediction of adverse events in older patients with acute coronary syndrome...
September 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28917060/lipids-and-ions-traverse-the-membrane-by-the-same-physical-pathway-in-the-nhtmem16-scramblase
#4
Tao Jiang, Kuai Yu, H Criss Hartzell, Emad Tajkhorshid
From bacteria to mammals, different phospholipid species are segregated between the inner and outer leaflets of the plasma membrane by ATP-dependent lipid transporters. Disruption of this asymmetry by ATP-independent phospholipid scrambling is important in cellular signaling, but its mechanism remains incompletely understood. Using MD simulations coupled with experimental assays, we show that the surface hydrophilic transmembrane cavity exposed to the lipid bilayer on the fungal scramblase nhTMEM16 serves as the pathway for both lipid translocation and ion conduction across the membrane...
September 16, 2017: ELife
https://www.readbyqxmd.com/read/28916436/treating-overactive-bladder-in-older-patients-with-a-combination-of-mirabegron-and-solifenacin-a-prespecified-analysis-from-the-beside-study
#5
William Gibson, Scott MacDiarmid, Moses Huang, Emad Siddiqui, Matthias Stölzel, Nurul Choudhury, Marcus J Drake
BACKGROUND: The BESIDE study demonstrated that combination therapy (mirabegron and solifenacin 5mg) improved overactive bladder symptoms versus solifenacin 5mg or 10mg, and was well tolerated. OBJECTIVE: To ensure efficacy and safety is maintained in older patients (>65 yr), who usually experience greater symptom severity and comorbidities, a prespecified subanalysis stratified by age group was conducted. DESIGN, SETTING, AND PARTICIPANTS: Patients remaining incontinent (≥1 episode during 3-d diary) following 4-wk single-blind daily solifenacin 5mg were randomized 1:1:1 to a daily double-blind combination (solifenacin 5mg and mirabegron 25mg, increased to 50mg at wk 4), solifenacin 5mg or 10mg for 12 wk...
September 12, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28911675/phenolic-constituents-of-pulicaria-undulata-l-c-a-mey-sub-sp-undulata-asteraceae-antioxidant-protective-effects-and-chemosystematic-significances
#6
Sameh R Hussein, Mona M Marzouk, Maha M Soltan, Emad K Ahmed, Mahmoud M Said, Ahmed R Hamed
One new naturally isoflavone compound, 5,7,2',3',4' penta hydroxyl isoflavone-4'-O-β-glucopyranoside (1) was isolated from the aqueous methanol extract (AME) of Pulicaria undulata subsp. undulata, together with seven known compounds: kaempferol (2), kaempferol 3-O-β-glucoside (3), quercetin (4), quercetin 3-O-β-glucoside (5), quercetin 3-O-β-galactoside (6), quercetin 3,7-di OCH3 (7), and caffeic acid (8). Their structures were established through chemical (acid hydrolysis) and spectral analysis (UV, NMR, and ESIM)...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28903949/intramuscular-tendon-involvement-on-mri-has-limited-value-for-predicting-time-to-return-to-play-following-acute-hamstring-injury
#7
Anne D van der Made, Emad Almusa, Rod Whiteley, Bruce Hamilton, Cristiano Eirale, Frank van Hellemondt, Johannes L Tol
BACKGROUND: Hamstring injury with intramuscular tendon involvement is regarded as a serious injury with a delay in return to play (RTP) of more than 50 days and reinjury rates up to 63%. However, this reputation is based on retrospective case series with high risk of bias. OBJECTIVE: Determine whether intramuscular tendon involvement is associated with delayed RTP and elevated rates of reinjury. METHODS: MRI of male athletes with an acute hamstring injury was obtained within 5 days of injury...
September 13, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28894765/active-phantoms-a-paradigm-for-ultrasound-calibration-using-phantom-feedback
#8
Alexis Cheng, Xiaoyu Guo, Haichong K Zhang, Hyun Jae Kang, Ralph Etienne-Cummings, Emad M Boctor
In ultrasound (US)-guided medical procedures, accurate tracking of interventional tools is crucial to patient safety and clinical outcome. This requires a calibration procedure to recover the relationship between the US image and the tracking coordinate system. In literature, calibration has been performed on passive phantoms, which depend on image quality and parameters, such as frequency, depth, and beam-thickness as well as in-plane assumptions. In this work, we introduce an active phantom for US calibration...
July 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28891944/new-tetra-schiff-bases-as-efficient-photostabilizers-for-poly-vinyl-chloride
#9
Dina S Ahmed, Gamal A El-Hiti, Ayad S Hameed, Emad Yousif, Ahmed Ahmed
Three new tetra-Schiff bases were synthesized and characterized to be used as photostabilizers for poly(vinyl chloride) (PVC) films. The photostability of PVC films (40 μm thickness) in the presence of Schiff bases (0.5 wt %) upon irradiation (300 h) with a UV light (λmax = 365 nm and light intensity = 6.43 × 10(-9) ein∙dm(-3)∙s(-1)) was examined using various spectroscopic measurements and surface morphology analysis. The changes in various functional groups' indices, weight and viscosity average molecular weight of PVC films were monitored against irradiation time...
September 9, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28888106/stereo-vision-three-dimensional-reconstruction-of-curvilinear-structures-imaged-with-a-tem
#10
Emad Oveisi, Antoine Letouzey, Sandro De Zanet, Guillaume Lucas, Marco Cantoni, Pascal Fua, Cécile Hébert
Deriving accurate three-dimensional (3-D) structural information of materials at the nanometre level is often crucial for understanding their properties. Tomography in transmission electron microscopy (TEM) is a powerful technique that provides such information. It is however demanding and sometimes inapplicable, as it requires the acquisition of multiple images within a large tilt arc and hence prolonged exposure to electrons. In some cases, prior knowledge about the structure can tremendously simplify the 3-D reconstruction if incorporated adequately...
August 30, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28882165/successful-treatment-of-acute-renal-failure-secondary-to-complicated-infective-endocarditis-by-peritoneal-dialysis-a-case-report
#11
Aisha M Al-Osail, Ibrahim M Al-Zahrani, Abdullah A Al-Abdulwahab, Sarah M Alhajri, Emad M Al-Osail, Abdullah K Al-Hwiesh, Fahad A Al-Muhanna
BACKGROUND: Infective endocarditis is one of the most common infections among intravenous drug addicts. Its complications can affect many systems, and these can include acute renal failure. There is a scarcity of cases in the literature related to acute renal failure secondary to infective endocarditis treated with peritoneal dialysis. In this paper, the case of a 48-year-old Saudi male is reported, who presented with features suggestive of infective endocarditis and who developed acute kidney injury that was treated successfully with high tidal volume automated peritoneal dialysis...
September 7, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28878280/tilt-less-3-d-electron-imaging-and-reconstruction-of-complex-curvilinear-structures
#12
Emad Oveisi, Antoine Letouzey, Duncan T L Alexander, Quentin Jeangros, Robin Schäublin, Guillaume Lucas, Pascal Fua, Cécile Hébert
The ability to obtain three-dimensional (3-D) information about morphologies of nanostructures elucidates many interesting properties of materials in both physical and biological sciences. Here we demonstrate a novel method in scanning transmission electron microscopy (STEM) that gives a fast and reliable assessment of the 3-D configuration of curvilinear nanostructures, all without needing to tilt the sample through an arc. Using one-dimensional crystalline defects known as dislocations as a prototypical example of a complex curvilinear object, we demonstrate their 3-D reconstruction two orders of magnitude faster than by standard tilt-arc TEM tomographic techniques, from data recorded by selecting different ray paths of the convergent STEM probe...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28863070/evaluation-of-microscopic-changes-in-fallopian-tubes-of-brca-mutation-carriers-by-morphometric-analysis-of-histologic-slides-a-preliminary-pilot-study
#13
Amnon Amit, Edmond Sabo, Yaniv Zohar, Einat Trugman, Irena Pranovich, Ari Reiss, Emad Matanes, Geula Klorin
Mutations in BRCA genes increase the risk of ovarian cancer, yet no method for early diagnosis is available. Some serous ovarian tumors are hypothesized to stem from cells of the fallopian tube fimbria. Using a novel method of computerized morphometry of the fimbrial epithelium, this study aimed to detect morphologic differences in noncancerous fimbriae between BRCA mutation carriers and noncarriers, and between healthy and serous ovarian cancer patients. Twenty-four fimbriae from healthy women (13 BRCA+, 11 BRCA-) and 21 fimbriae from women with serous ovarian cancer (10 BRCA+, 11 BRCA-), all reported as "normal" by hematoxylin and eosin examination, were subjected to computerized histomorphometric analysis...
August 31, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28861383/robotic-transaxillary-parathyroidectomy
#14
Khuzema Mohsin, Hassan Alzahrani, Daniah Bu Ali, Sang-Wook Kang, Emad Kandil
We recently reported on the safety and feasibility of robotic transaxillary approaches for parathyroid surgeries with benefit of avoiding a visible cervical scar. Herein, we demonstrate our technique with utilization of intraoperative nerve monitoring and indocyanine green (ICG) imaging. The patient was discharged a few hours after the surgery.
August 2017: Gland Surgery
https://www.readbyqxmd.com/read/28861377/concomitant-thyroid-disease-and-primary-hyperparathyroidism-in-patients-undergoing-parathyroidectomy-or-thyroidectomy
#15
Marie-Christine Wright, Kelly Jensen, Hossam Mohamed, Carolyn Drake, Khuzema Mohsin, Dominique Monlezun, Nuha Alsaleh, Emad Kandil
BACKGROUND: Thyroid abnormalities have been found intraoperatively during parathyroidectomy and have resulted in concomitant thyroidectomy. The identification of concomitant disease is important prior to primary operation in order to minimize reoperations. This study investigates the incidence of concomitant primary hyperparathyroidism (PHPT) and thyroid nodular disease in patients undergoing thyroidectomy or parathyroidectomy. METHODS: We performed a retrospective review of prospectively gathered data for 621 patients who underwent thyroidectomy, parathyroidectomy, or both at Tulane Medical Center...
August 2017: Gland Surgery
https://www.readbyqxmd.com/read/28861367/safety-of-same-day-thyroidectomy-meta-analysis-and-systematic-review
#16
Helmi Khadra, Salah Mohamed, Adam Hauch, John Carter, Tian Hu, Emad Kandil
BACKGROUND: Performance of thyroid surgery as a same day surgery procedure has been a controversial topic. This study aimed to compare the safety and efficacy of outpatient thyroid surgery with inpatient thyroid surgery by meta-analysis of current literature. METHODS: Articles were identified from the following keyword searches: outpatient thyroidectomy/thyroid surgery, same day thyroidectomy/thyroid surgery. Outcomes included perioperative complications including recurrent laryngeal nerve (RLN) injury, hypocalcemia, and readmissions...
August 2017: Gland Surgery
https://www.readbyqxmd.com/read/28858790/image-registration-based-on-low-rank-matrix-rank-regularized-ssd
#17
Aboozar Ghaffari, Emad Fatemizadeh
Similarity measure is a main core of image registration algorithms. Spatially varying intensity distortion is an important challenge which affects the performance of similarity measures. Correlation among pixels is the main characteristic of this distortion. Similarity measures such as sum-of-squareddifferences (SSD) and mutual information (MI) ignore this correlation; Hence, perfect registration cannot be achieved in the presence of this distortion. In this paper, we model this correlation with the aid of the low rank matrix theory...
August 25, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28829761/rho-gtpase-activating-protein-18-a-biomarker-associated-with-good-prognosis-in-invasive-breast-cancer
#18
Mohammed A Aleskandarany, Sultan Sonbul, Rachel Surridge, Abhik Mukherjee, Carlos Caldas, Maria Diez-Rodriguez, Ibraheem Ashankyty, Khalil I Albrahim, Ahmed M Elmouna, Ritu Aneja, Stewart G Martin, Ian O Ellis, Andrew R Green, Emad A Rakha
BACKGROUND: The prognostic value of lymphovascular invasion (LVI) in breast cancer (BC) has been demonstrated in several independent studies. However, identification of driver molecules for LVI remains a challenging task. Large-scale transcriptomic profiling of histologically validated LVI can potentially identify genes that regulate LVI. METHODS: Integrative bio-informatics analyses of the METABRIC study were performed utilising a subset of strictly defined LVI using histological and immunohistochemical (IHC) criteria...
August 22, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28816771/primary-omental-torsion-in-a-pediatric-patient-case-report-and-review-of-the-literature
#19
Emad S Madha, Timothy D Kane, Mioara D Manole
Primary omental torsion is a rare cause of acute abdominal pain with a clinical presentation resembling acute appendicitis. Here, we report the case of a 7-year-old child presenting with right lower quadrant pain. Primary omental torsion was discovered upon laparoscopy, and the torsed omentum was excised without postoperative complications. Potential causes, contributing factors, diagnosis, and treatment are discussed.
July 3, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28816184/early-screening-of-diabetes-and-hypertension-in-primary-care-dental-clinics-at-king-saud-university-in-riyadh-kingdom-of-saudi-arabia
#20
Emad M Hadlaq, Ziyad T Faraj, Fahad M Al Gamdi, Faisal A Al Obathani, Mashael F Abuabat, Kamran H Awan
INTRODUCTION: Diabetes mellitus and hypertension are the leading chronic diseases in Saudi Arabia; 23.1% of the Saudi population are diabetic and 25.5% are hypertensive. This cross-sectional study was made on dental setting to determine the effectiveness of screening of diabetes and hypertension in dental clinics. MATERIALS AND METHODS: This study was carried out in the primary care dental clinics at the Dental College in King Saud University in Riyadh, Saudi Arabia...
August 1, 2017: Journal of Contemporary Dental Practice
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