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https://www.readbyqxmd.com/read/29784499/erratum-to-antibodies-derived-from-a-toxoid-mefa-multiepitope-fusion-antigen-show-neutralizing-activities-against-heat-labile-toxin-lt-heat-stable-toxins-sta-stb-and-shiga-toxin-2e-stx2e-of-porcine-enterotoxigenic-escherichia-coli-etec-vet-microbiol-202-2017
#1
https://www.readbyqxmd.com/read/29781182/valve-in-valve-transcatheter-aortic-valve-implantation-viv-tavi-versus-redo-surgical-aortic-valve-replacement-redo-savr-a-systematic-review-and-meta-analysis
#2
REVIEW
Nikhil Nalluri, Varunsiri Atti, Abdullah B Munir, Boutros Karam, Nileshkumar J Patel, Varun Kumar, Praveen Vemula, Susruth Edla, Deepak Asti, Amrutha Paturu, Sriramya Gayam, Jonathan Spagnola, Emad Barsoum, Gregory A Maniatis, Frank Tamburrino, Ruben Kandov, James Lafferty, Chad Kliger
BACKGROUND: Bioprosthetic (BP) valves have been increasingly used for aortic valve replacement over the last decade. Due to their limited durability, patients presenting with failed BP valves are rising. Valve in Valve - Transcatheter Aortic Valve Implantation (ViV-TAVI) emerged as an alternative to the gold standard redo-Surgical Aortic Valve Replacement (redo-SAVR). However, the utility of ViV-TAVI is poorly understood. METHODS: A systematic electronic search of the scientific literature was done in PubMed, EMBASE, SCOPUS, Google Scholar, and ClinicalTrials...
May 20, 2018: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29778666/mycophenolate-mofetil-for-induction-and-maintenance-of-remission-in-na%C3%A3-ve-patients-with-granulomatosis-with-polyangiitis-without-renal-involvement
#3
Yasser Emad, Yasser Ragab, Johannes J Rasker
Antineutrophil cytoplasmic antibodies (ANCA) associated vasculitides include granulomatosis with polyangiitis (GPA, previously called Wegener's), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA), previously called Churg-Strauss). In this report we used mycophenolate mofetil (MMF) and steroids to induce and maintain remission in two newly diagnosed cases with c-ANCA associated GPA. The two patients' maintained remission with no disease relapses during one year follow-up...
May 16, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29774097/natriuretic-peptides-system-in-the-pulmonary-tissue-of-rats-with-heart-failure-potential-involvement-in-lung-edema-and-inflammation
#4
Emad E Khoury, Safa Kinaneh, Doron Aronson, Offer Amir, Diab Ghanim, Natalia Volinsky, Zaher Azzam, Zaid Abassi
Congestive heart failure (CHF) often leads to progressive cardiac hypertrophy and salt/water retention as evident by peripheral and lung edema. Although the pathogenesis of CHF remains largely unclarified, it is widely accepted that neurohormonal changes and inflammatory processes are profoundly involved in structural and functional deterioration of vital organs including, heart, kidney and lungs. Corin, a cardiac serine protease, is responsible for converting pro-ANP and pro-BNP to biologically active natriuretic peptides (NPs)...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29770314/factors-leading-to-pancreatic-resection-in-patients-with-pancreatic-cancer-a-national-perspective
#5
David T Pointer, Zaid Al-Qurayshi, John B Hamner, Douglas P Slakey, Emad Kandil
Background: Resection is the only option for potential cure in pancreatic cancer. Patients admitted for resection may have the procedure deferred during their hospitalization. We aim to identify factors that lead pancreatic cancer patients to undergo resection. Methods: An analysis utilizing the Nationwide Inpatient Sample (NIS) database, 2003-2009. Study population included adults (≥18 years) with pancreatic cancer who underwent either pancreatic resection or other interventions...
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29766191/palladium-mediated-deallylation-in-fully-aqueous-conditions-for-native-chemical-ligation-at-aspartic-and-glutamic-acid-sites
#6
Muhammad Jbara, Emad Eid, Ashraf Brik
An efficient native chemical ligation approach at Asp and Glu sites is reported applying a hydrazide precursor, as a peptide thioester, and allyl protection at the side chain of Asp and Glu. The allyl protection was efficiently removed, after the ligation step, using the water-soluble palladium complex [Pd(allyl)Cl]2 and glutathione within a few minutes under fully aqueous conditions.
May 16, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29765578/lipid-lowering-drugs-statins-and-peripheral-neuropathy
#7
Mohammadreza Emad, Hosein Arjmand, Hamid Reza Farpour, Bahareh Kardeh
Background and aim: Peripheral neuropathy is a disorder with often unknown causes. Some drugs, including statins, are proposed to be among the causes of peripheral neuropathy. This study aimed at evaluating this condition by electrodiagnostic study among patients who had received statins. Methods: This case-control study was conducted in Shiraz, Iran in 2015, and included 39 patients aged 35-55 who had received statins for at least 6 months, and 39 healthy matched controls...
March 2018: Electronic Physician
https://www.readbyqxmd.com/read/29764229/use-of-surgical-hemostatic-powder-for-ep-device-implantation-reduces-postoperative-rates-of-pocket-hematoma-and-infection
#8
Olga Reynbakh, Philippe Akhrass, Nektarios Souvaliotis, Chaithanya K Pamidimukala, Hasnun Nahar, Joseph Bastawrose, Pierre Boktor, Joshua E Aziz, Davendra Mehta, Emad F Aziz
BACKGROUND: Surgical site bleeding and infection are potential complications after EP device implantation procedures. To date, there is a wide variety of tools for management of intraoperative bleeding but it still remains unclear what methods are preferred. OBJECTIVE: The aim of our study is to compare the rate of complications in patients who underwent Cardiac Implantable Electronic devices (CIED) implantation utilizing Arista as a hemostatic agent to the rate of complications in those patients who underwent standard procedure protocol without Arista...
May 15, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29756350/selective-parathyroid-venous-sampling-in-primary-hyperparathyroidism-a-systematic-review-and-meta-analysis
#9
REVIEW
Kareem Ibraheem, Eman A Toraih, Antoine B Haddad, Mahmoud Farag, Gregory W Randolph, Emad Kandil
OBJECTIVE: Minimally invasive parathyroidectomy requires accurate preoperative localization techniques. There is considerable controversy about the effectiveness of selective parathyroid venous sampling (sPVS) in primary hyperparathyroidism (PHPT) patients. The aim of this meta-analysis is to examine the diagnostic accuracy of sPVS as a preoperative localization modality in PHPT. METHODS: Studies evaluating the diagnostic accuracy of sPVS for PHPT were electronically searched in the PubMed, EMBASE, Web of Science, and Cochrane Controlled Trials Register databases...
May 14, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29753667/incidental-diagnosis-of-congenital-tracheal-stenosis-in-children-with-congenital-heart-disease-presenting-for-cardiac-surgery
#10
Ashraf Resheidat, Tamra Kelly, Emad Mossad
No abstract text is available yet for this article.
April 12, 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29743120/cavernous-sinus-involvement-in-human-papillomavirus-associated-oropharyngeal-squamous-cell-carcinoma-case-report-of-an-atypical-site-of-distant-metastasis
#11
David Forner, Derek Wilke, Matthew H Rigby, Sidney Croul, Anuradha Mishra, Emad Massoud, David B Clarke, Nathan Lamond
BACKGROUND: HPV-associated OSCC (HPV-OSCC) has been determined to be a distinct disease entity from non-HPV associated OSCC. Patients affected by HPV-OSCC generally have a more favourable prognosis, with improved rates of locoregional control and survival compared with their non-HPV counterparts. Despite this, HPV-OSCC has a similar rate of distant metastases. Interestingly, recent evidence has emerged that demonstrates more frequent atypical metastasis patterns when compared to non-HPV associated disease...
May 9, 2018: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29739933/recurrent-hotspot-mutations-in-hras-q61-and-pi3k-akt-pathway-genes-as-drivers-of-breast-adenomyoepitheliomas
#12
Felipe C Geyer, Anqi Li, Anastasios D Papanastasiou, Alison Smith, Pier Selenica, Kathleen A Burke, Marcia Edelweiss, Huei-Chi Wen, Salvatore Piscuoglio, Anne M Schultheis, Luciano G Martelotto, Fresia Pareja, Rahul Kumar, Alissa Brandes, Dan Fan, Thais Basili, Arnaud Da Cruz Paula, John R Lozada, Pedro Blecua, Simone Muenst, Achim A Jungbluth, Maria P Foschini, Hannah Y Wen, Edi Brogi, Juan Palazzo, Brian P Rubin, Charlotte K Y Ng, Larry Norton, Zsuzsanna Varga, Ian O Ellis, Emad A Rakha, Sarat Chandarlapaty, Britta Weigelt, Jorge S Reis-Filho
Adenomyoepithelioma of the breast is a rare tumor characterized by epithelial-myoepithelial differentiation, whose genetic underpinning is largely unknown. Here we show through whole-exome and targeted massively parallel sequencing analysis that whilst estrogen receptor (ER)-positive adenomyoepitheliomas display PIK3CA or AKT1 activating mutations, ER-negative adenomyoepitheliomas harbor highly recurrent codon Q61 HRAS hotspot mutations, which co-occur with PIK3CA or PIK3R1 mutations. In two- and three-dimensional cell culture models, forced expression of HRASQ61R in non-malignant ER-negative breast epithelial cells with or without a PIK3CAH1047R somatic knock-in results in transformation and the acquisition of the cardinal features of adenomyoepitheliomas, including the expression of myoepithelial markers, a reduction in E-cadherin expression, and an increase in AKT signaling...
May 8, 2018: Nature Communications
https://www.readbyqxmd.com/read/29738009/serotonin-and-serotonin-transporter-levels-in-autistic-children
#13
Haidar A Abdulamir, Omar F Abdul-Rasheed, Emad A Abdulghani
OBJECTIVES: To assess the possible correlation between serotonin and serotonin transporter (SERT) with the autism severity and investigate the association between these parameters in autistic children to assess their possible role for diagnosis of autism severity. METHODS: A comparative cross-sectional study was carried out in the Chemistry and Biochemistry Department, College of Medicine, Al-Nahrain University, Baghdad, Iraq while the samples were taken from 60 male autistic children recruited to the Department of Pediatrics at Al-Sader Hospital, Baghdad, Iraq between November 2014 amd April 2015...
May 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29738004/kidney-cancer-in-saudi-arabia-a-25-year-analysis-of-epidemiology-and-risk-factors-in-a-tertiary-center
#14
Sultan S Alkhateeb, Ali S Alothman, Abdulmalik M Addar, Raed A Alqahtani, Tarek M Mansi, Emad M Masuadi
OBJECTIVES: To evaluate available epidemiological data and risk factors for kidney cancer in a tertiary care center in Riyadh, Saudi Arabia, over a period of 25 years. METHODS: This retrospective study conducted in a tertiary care center included all adult patients with primary kidney cancer who presented and were managed between 1990 and 2015. Based on this information, we forecast the incidence of the disease in our center over the next 5 years (2016 to 2020)...
May 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29736012/modified-16-dot-plication-technique-for-correction-of-penile-curvature-prevention-of-knot-related-complications
#15
Emad A Salem
Penile curvature is a common urological disease. Tunical plication for correction of penile curvature has been much popularized being simpler, adjustable to avoid overcorrection, less bleeding, and less postoperative erectile dysfunction. This study aims to assess the results of modified 16-dot plication technique for correction of congenital and acquired penile curvature and avoidance of knot-associated complications. Eighteen patients underwent correction of their penile curvature using the modified 16-dot plication technique between January 2014 and October 2015...
May 8, 2018: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29730134/penile-wobble-effect-proximal-corporal-deformities-as-a-cause-of-penile-prosthesis-failure
#16
Emad Rajih, Arthur L Burnett
INTRODUCTION: Penile structural defects can contribute toward penile prosthesis (PP) surgical complications and suboptimal outcomes. Despite modern improvements in techniques of inflatable PP (IPP) surgeries, suboptimal outcomes arise secondary to unrecognized proximal corporal abnormalities. AIM: To describe a new observation of IPP failure (wobbly penis) secondary to proximal corporal deformities. METHODS: We performed a retrospective analysis of the Johns Hopkins institutional database of patients who had IPP surgery from May 2006 to March 2017...
May 2, 2018: Sexual Medicine
https://www.readbyqxmd.com/read/29725689/a-cross-stitched-peptide-with-improved-helicity-and-proteolytic-stability
#17
Thomas E Speltz, Christopher G Mayne, Sean W Fanning, Zamia Siddiqui, Emad Tajkhorshid, Geoffrey L Greene, Terry W Moore
A new computational approach to obtain quantitative energy profiles for helix folding was used in the design of orthogonal hydrocarbon and lactam bicyclic peptides. The proteolytically stable, "cross-stitched" peptide SRC2-BCP1 shows nanomolar affinity for estrogen receptor α and X-ray crystallography confirms a helical binding pose.
May 4, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29722058/breast-cancer-intra-tumour-heterogeneity-current-status-and-clinical-implications
#18
REVIEW
Chitra Joseph, Athanasia Papadaki, Maryam Althobiti, Mansour Alsaleem, Mohammed A Aleskandarany, Emad A Rakha
Breast cancer (BC) is a heterogeneous disease that varies in presentation, morphological features, behaviour and response to therapy. High throughput molecular profiling studies have revolutionised our understanding of BC heterogeneity and demonstrated that molecular portraits of tumours are not only variable between tumours but also within individual tumours. Current evidence indicates that spatial and temporal intra-tumour heterogeneity of BC exists at levels beyond common anticipations. Intra-tumoural heterogeneity poses critical challenges in the diagnosis, prediction of behaviour and management of BC...
May 2, 2018: Histopathology
https://www.readbyqxmd.com/read/29720211/atypical-ductal-hyperplasia-update-on-diagnosis-management-and-molecular-landscape
#19
REVIEW
Tanjina Kader, Prue Hill, Emad A Rakha, Ian G Campbell, Kylie L Gorringe
BACKGROUND: Atypical ductal hyperplasia (ADH) is a common diagnosis in the mammographic era and a significant clinical problem with wide variation in diagnosis and treatment. After a diagnosis of ADH on biopsy a proportion are upgraded to carcinoma upon excision; however, the remainder of patients are overtreated. While ADH is considered a non-obligate precursor of invasive carcinoma, the molecular taxonomy remains unknown. MAIN TEXT: Although a few studies have revealed some of the key genomic characteristics of ADH, a clear understanding of the molecular changes associated with breast cancer progression has been limited by inadequately powered studies and low resolution methodology...
May 2, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29717926/the-association-of-dietary-intakes-of-total-polyphenol-and-its-subclasses-with-the-risk-of-metabolic-syndrome-tehran-lipid-and-glucose-study
#20
Gobon Sohrab, Samira Ebrahimof, Somayeh Hosseinpour-Niazi, Emad Yuzbashian, Parvin Mirmiran, Fereidoun Azizi
BACKGROUND: The purpose of the present study was to investigate the longitudinal association of total polyphenol and its main four subclasses intake with metabolic syndrome (MetS) and its components. METHODS: The present prospective study was conducted on 1265 Tehranian adults, aged 19-74 years. Usual dietary intake was evaluated using a validated food-frequency questionnaire. MetS was defined using NCEP ATP III guidelines. Intakes of total polyphenol and its four main subclasses, including flavonoids, phenolic acids, stilbenes, and lignans, were estimated using Phenol-Explorer database...
May 2, 2018: Metabolic Syndrome and related Disorders
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