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https://www.readbyqxmd.com/read/27919446/immunohistochemistry-as-an-accurate-tool-for-evaluating-braf-v600e-mutation-in-130-samples-of-papillary-thyroid-cancer
#1
Zakaria Y Abd Elmageed, Andrew B Sholl, Koji Tsumagari, Zaid Al-Qurayshi, Fulvio Basolo, Krzysztof Moroz, A Hamid Boulares, Paul Friedlander, Paulo Miccoli, Emad Kandil
BACKGROUND: BRAF(V600E) mutation has been investigated by immunohistochemistry and has shown high sensitivity and specificity. We aim to investigate the accuracy of immunohistochemistry versus molecular testing of BRAF(V600E) in papillary thyroid cancer using a large number of polymerase chain reaction-positive BRAF(V600E) papillary thyroid cancer tissues. METHODS: We stained 130 formalin-fixed papillary thyroid cancer specimens using the VE1 antibody: 100 BRAF(V600E) positive and 30 BRAF(V600E) negative confirmed by PCR...
December 2, 2016: Surgery
https://www.readbyqxmd.com/read/27918796/identifying-intraoperative-nerve-monitoring-in-thyroid-surgery-using-administrative-databases-reply
#2
Zaid Al-Qurayshi, Gregory W Randolph, Emad Kandil
No abstract text is available yet for this article.
December 1, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27915398/the-interactive-electrode-localization-utility-software-for-automatic-sorting-and-labeling-of-intracranial-subdural-electrodes
#3
Roan A LaPlante, Wei Tang, Noam Peled, Deborah I Vallejo, Mia Borzello, Darin D Dougherty, Emad N Eskandar, Alik S Widge, Sydney S Cash, Steven M Stufflebeam
PURPOSE: Existing methods for sorting, labeling, registering, and across-subject localization of electrodes in intracranial encephalography (iEEG) may involve laborious work requiring manual inspection of radiological images. METHODS: We describe a new open-source software package, the interactive electrode localization utility which presents a full pipeline for the registration, localization, and labeling of iEEG electrodes from CT and MR images. In addition, we describe a method to automatically sort and label electrodes from subdural grids of known geometry...
December 3, 2016: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/27914769/clinicopathological-and-molecular-characteristics-of-ku-70-80-expression-in-nigerian-breast-cancer-and-its-potential-therapeutic-implications
#4
Ayodeji O J Agboola, Henry O Ebili, Victoria O Iyawe, Adekunbiola A F Banjo, Babatunde A Salami, Emad A Rakha, Chrstopher C Nolan, Ian O Ellis, Andrew R Green
Ku 70/80 is a regulator of the Non-Homologous End Joining (NHEJ) roles in clinicopathological features, and has prognostic significance in breast cancer (BC) in Caucasian populations. However, its significance in the Nigerian BC population, which is characterized by a higher rate of the triple-negative and basal phenotype, p53 mutation rate and BRCA1 deficiency, still needs to be investigated. We hypothesize that Ku70/80 expression shows adverse expression in Nigerian BC and, furthermore, that it is likely to have a therapeutic implication for Black BC management...
October 25, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27911947/the-yersinia-pestis-effector-yopm-inhibits-pyrin-inflammasome-activation
#5
Dmitry Ratner, M Pontus A Orning, Megan K Proulx, Donghai Wang, Mikhail A Gavrilin, Mark D Wewers, Emad S Alnemri, Peter F Johnson, Bettina Lee, Joan Mecsas, Nobuhiko Kayagaki, Jon D Goguen, Egil Lien
Type III secretion systems (T3SS) are central virulence factors for many pathogenic Gram-negative bacteria, and secreted T3SS effectors can block key aspects of host cell signaling. To counter this, innate immune responses can also sense some T3SS components to initiate anti-bacterial mechanisms. The Yersinia pestis T3SS is particularly effective and sophisticated in manipulating the production of pro-inflammatory cytokines IL-1β and IL-18, which are typically processed into their mature forms by active caspase-1 following inflammasome formation...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27910207/editorial-comment-from-dr-ibrahim-to-testicular-sperm-extraction-for-patients-with-spinal-cord-injury-related-anejaculation-a-single-center-experience
#6
Emad Ibrahim
No abstract text is available yet for this article.
December 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/27909551/post-endoscopic-retrograde-cholangiopancreatography-pancreatitis-risk-factors-and-predictors-of-severity
#7
Ayman El Nakeeb, Ehab El Hanafy, Tarek Salah, Ehab Atef, Hosam Hamed, Ahmad M Sultan, Emad Hamdy, Mohamed Said, Ahmed A El Geidie, Tharwat Kandil, Mohamed El Shobari, Gamal El Ebidy
AIM: To detect risk factors for post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) and investigate the predictors of its severity. METHODS: This is a prospective cohort study of all patients who underwent ERCP. Pre-ERCP data, intraoperative data, and post-ERCP data were collected. RESULTS: The study population consisted of 996 patients. Their mean age at presentation was 58.42 (± 14.72) years, and there were 454 male and 442 female patients...
November 16, 2016: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27903182/single-session-gamma-knife-radiosurgery-for-optic-pathway-hypothalamic-gliomas
#8
Amr M N El-Shehaby, Wael A Reda, Khaled M Abdel Karim, Reem M Emad Eldin, Ahmed M Nabeel
OBJECTIVE Because of their critical and central location, it is deemed necessary to fractionate when considering irradiating optic pathway/hypothalamic gliomas. Stereotactic fractionated radiotherapy is considered safer when dealing with gliomas in this location. In this study, the safety and efficacy of single-session stereotactic radiosurgery for optic pathway/hypothalamic gliomas were reviewed. METHODS Between December 2004 and June 2014, 22 patients with optic pathway/hypothalamic gliomas were treated by single-session Gamma Knife radiosurgery...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27902387/characterization-of-methicillin-resistant-staphylococcus-aureus-isolated-at-tripoli-medical-centre-libya-between-2008-and-2014
#9
Elloulu BenDarif, Asma Khalil, Abdunnabi Rayes, Emad Bennour, Abdulgader Dhawi, John J Lowe, Shawn Gibbs, Richard V Goering
Bacterial pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) represent a well-known public health problem affecting both healthcare-associated and community populations. Past studies have clearly shown the value of characterizing problem organisms including MRSA through the use of molecular techniques (i.e., strain typing), with the aim of informing local, regional, and national efforts in epidemiological analysis and infection control. The country of Libya represents a challenge for such analysis due to limited historical infectious disease information and major political unrest culminating in the Libyan Civil War (Libyan Revolution) in 2011...
November 1, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27894715/refractory-complex-gastrobroncho-cutaneous-fistula-after-laparoscopic-sleeve-gastrectomy-a-novel-technique-for-endoscopic-management
#10
Emad Abdallah, Hosam Hamed, Mohamed Fikry
No abstract text is available yet for this article.
September 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27894112/association-of-mbl2-gene-polymorphism-with-dental-caries-in-saudi-children
#11
Yousef M Alyousef, J Francis Borgio, Sayed AbdulAzeez, Naif Al-Masoud, Ali A Al-Ali, Emad Al-Shwaimi, Amein K Al-Ali
The high prevalence of dental caries in children worldwide is a major oral health problem which requires early intervention. Dental caries is mainly caused by the action of acids produced by bacteria in addition to many other factors. Recent genetic studies have reported that a number of genes are associated with the susceptibility to dental caries. The majority of these genes are associated with inflammation, increased susceptibility to infection, and dentine matrix formation. Using the TaqMan assay and direct DNA sequencing, the prevalence of 6 single-nucleotide polymorphisms (SNPs) in MMP9, MBL2, MMP2, and TIMP2 genes was determined in 102 children with caries and in 100 age-matched caries-free controls...
November 29, 2016: Caries Research
https://www.readbyqxmd.com/read/27884202/extending-colonic-mucosal-microbiome-analysis-assessment-of-colonic-lavage-as-a-proxy-for-endoscopic-colonic-biopsies
#12
Euan Watt, Matthew R Gemmell, Susan Berry, Mark Glaire, Freda Farquharson, Petra Louis, Graeme I Murray, Emad El-Omar, Georgina L Hold
BACKGROUND: Sequencing-based analysis has become a well-established approach to deciphering the composition of the gut microbiota. However, due to the complexity of accessing sufficient material from colonoscopic biopsy samples, most studies have focused on faecal microbiota analysis, even though it is recognised that differences exist between the microbial composition of colonic biopsies and faecal samples. We determined the suitability of colonic lavage samples to see if it had comparable microbial diversity composition to colonic biopsies as they are without the limitations associated with sample size...
November 25, 2016: Microbiome
https://www.readbyqxmd.com/read/27883330/effects-of-17%C3%AE-estradiol-e2-on-aqueous-organisms-and-its-treatment-problem-a-review
#13
Emad Nazari, Fatihah Suja
Natural estrogens, estrone (E1), 17β-estradiol (E2) and estriol (E3) are endocrine disrupting chemicals (EDCs) that are discharged consistently and directly into surface waters with wastewater treatment plants (WWPTs) effluents, disposal sludges and in storm-water runoff. The most common and highest potential natural estrogen that causes estrogen activity in wastewater influent is E2. This review describes and attempts to summarize the main problems involved in the removal of E2 from WWTP by traditional processes, which fundamentally rely on activated sludge and provide an insufficient treatment for E2, as well as advanced oxidation processes (AOPs) that are applied in tertiary section treatment works...
December 1, 2016: Reviews on Environmental Health
https://www.readbyqxmd.com/read/27879116/angiogenesis-model-with-erlang-distributed-delays
#14
Emad Attia, Marek Bodnar, Urszula Forys
We consider the model of angiogenesis process proposed by Bodnar and Foryś (2009) with time delays included into the vessels formation and tumour growth processes. Originally, discrete delays were considered, while in the present paper we focus on distributed delays and discuss specific results for the Erlang distributions. Analytical results concerning stability of positive steady states are illustrated by numerical results in which we also compare these results with those for discrete delays.
February 1, 2017: Mathematical Biosciences and Engineering: MBE
https://www.readbyqxmd.com/read/27878751/assessment-of-the-relationship-between-serum-paraoxonase-activity-and-epicardial-adipose-tissue-in-hemodialysis-patients
#15
Emad Abdallah, Samya El-Shishtawy, Nevine Sherif, Ahmed Ali, Omnia El-Bendary
PURPOSE: Paraoxonase-1 (PON-1) is a high-density lipoprotein-associated (HDL) enzyme, which has been shown to reduce susceptibility to low-density lipoprotein (LDL) peroxidation. Epicardial adipose tissue (EAT) is a marker of atherosclerosis. The aim of this study was to determine the relationship between PON-1 activity and EAT in hemodialysis (HD) patients. METHODS: This is a cross-sectional study conducted on 72 (43 males) HD patients with end-stage renal disease...
November 23, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27877017/study-of-the-antibacterial-and-antifungal-activities-of-synthetic-benzyl-bromides-ketones-and-corresponding-chalcone-derivatives
#16
Muhamad Ali K Shakhatreh, Mousa L Al-Smadi, Omar F Khabour, Fatima A Shuaibu, Emad I Hussein, Karem H Alzoubi
Several applications of chalcones and their derivatives encouraged researchers to increase their synthesis as an alternative for the treatment of pathogenic bacterial and fungal infections. In the present study, chalcone derivatives were synthesized through cross aldol condensation reaction between 4-(N,N-dimethylamino)benzaldehyde and multiarm aromatic ketones. The multiarm aromatic ketones were synthesized through nucleophilic substitution reaction between 4-hydroxy acetophenone and benzyl bromides. The benzyl bromides, multiarm aromatic ketones, and corresponding chalcone derivatives were evaluated for their activities against eleven clinical pathogenic Gram-positive, Gram-negative bacteria, and three pathogenic fungi by the disk diffusion method...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27877002/retracted-article-frequency-of-intestinal-protozoan-parasites-in-patients-with-gastrointestinal-disorders-in-south-of-karaj-iran
#17
Mohammad Sabzikarian, Saeideh Najafi, Hosein Amini Anabad, Vahid Behnod, Emad Yahaghi, Koorosh Ahmadi
No abstract text is available yet for this article.
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27872546/evaluation-of-root-canal-morphology-of-maxillary-second-premolars-in-a-saudi-arabian-sub-population-an-in-vitro-microcomputed-tomography-study
#18
Mutasim Elnour, Abdul Khabeer, Emad AlShwaimi
AIM: To investigate the root canal morphology of maxillary second premolars in a Saudi Arabian subpopulation using microcomputed tomography (micro-CT). METHODOLOGY: Micro-CT analysis was performed on 100 maxillary second premolars. The anatomy of each tooth (number of roots, canals, orifices, and apical foramina, and the presence of apical deltas and accessory canals) was analyzed from reconstructed three-dimensional images. RESULTS: The most common morphology was a single root (67%), followed by two roots (30%), and three roots (3%)...
October 2016: Saudi Dental Journal
https://www.readbyqxmd.com/read/27865680/mortality-benefit-of-long-term-angiotensin-converting-enzyme-inhibitors-or-angiotensin-receptor-blockers-after-successful-percutaneous-coronary-intervention-in-non-st-elevation-acute-myocardial-infarction
#19
María Cristina González-Cambeiro, Andrea López-López, Emad Abu-Assi, Sergio Raposeiras-Roubín, Carlos Peña-Gil, José García-Acuña, Ramón González-Juanatey
INTRODUCTION AND OBJECTIVES: Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) have been shown to reduce mortality after myocardial infarction (MI). Current guidelines recommend their prescription in all patients after MI. Limited data are available on whether ACEIs/ARBs still improve prognosis in the contemporary era of non-ST elevation MI (NSTEMI) management. We aimed to evaluate the mortality benefit of ACEIs/ARBs in NSTEMI patients treated successfully with percutaneous coronary intervention (PCI)...
December 2016: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/27861937/electrophysiological-identification-of-nonrecurrent-laryngeal-nerves
#20
Emad Kandil, Muhammad A Anwar, Jeremy Bamford, Rizwan Aslam, Gregory W Randolph
OBJECTIVES/HYPOTHESIS: The nonrecurrent laryngeal nerve (NRLN) is a common anatomic variation of the right recurrent laryngeal nerve (RLN), which has been associated with an increased risk of injury during thyroid and parathyroid surgery. We suggest that early successful identification using intraoperative nerve monitoring (IONM) and preservation of this variant will help the surgeon to avoid injury to this nerve. Our objective was to examine the electrophysiological parameters of the NRLN and the efficacy of IONM for successful identification of the NRLN...
November 15, 2016: Laryngoscope
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