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https://www.readbyqxmd.com/read/28335987/community-health-indicators-associated-with-outcomes-of-pancreatectomy
#1
Lauren Slakey Pointer, Zaid Al-Qurayshi, David Taylor Pointer, Emad Kandil, Douglas Philip Slakey
PURPOSE: This study evaluates the association of environmental, social and health risk factors in relation to outcomes of pancreatic surgery. METHODS: Patients who underwent pancreatectomy with a 30 day postoperative follow up in Florida, New York and Washington states were identified using the State Inpatient Databases (SID) from 2010 to 2011. This data was merged with community health indicators complied from the County Health Ranking database. Fourteen community health indicators were used to determine higher risk communities...
March 10, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28328208/ubiquitin-signalling-chemistry-comes-to-rescue
#2
Sachitanand M Mali, Sumeet K Singh, Emad Eid, Ashraf Brik
Posttranslational modification of proteins by ubiquitin, i.e. ubiquitination, mediates a variety of cellular processes ranging from protein homeostasis, cell cycle, DNA repair to viral infections. Understanding the molecular mechanism of ubiquitination in these events is the basis for unraveling its precise role in health and disease. However, the inherent complexity of ubiquitin signalling due to the high atomic complexity of ubiquitin conjugates, where ubiquitin is attached to other ubiquitin molecules and to protein substrates in various forms, imposes a major challenge for these studies...
March 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28327362/esophageal-fibrous-band-causing-dysphagia-in-an-hiv-patient
#3
Shani Woolard, Paula Adamson, Emad Qayed
No abstract text is available yet for this article.
March 18, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28317912/the-soft-mechanical-signature-of-glial-scars-in-the-central-nervous-system
#4
Emad Moeendarbary, Isabell P Weber, Graham K Sheridan, David E Koser, Sara Soleman, Barbara Haenzi, Elizabeth J Bradbury, James Fawcett, Kristian Franze
Injury to the central nervous system (CNS) alters the molecular and cellular composition of neural tissue and leads to glial scarring, which inhibits the regrowth of damaged axons. Mammalian glial scars supposedly form a chemical and mechanical barrier to neuronal regeneration. While tremendous effort has been devoted to identifying molecular characteristics of the scar, very little is known about its mechanical properties. Here we characterize spatiotemporal changes of the elastic stiffness of the injured rat neocortex and spinal cord at 1...
March 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28301304/neuroprotective-and-therapeutic-effect-of-caffeine-on-the-rat-model-of-parkinson-s-disease-induced-by-rotenone
#5
Yasser A Khadrawy, Ahmed M Salem, Karima A El-Shamy, Emad K Ahmed, Nevein N Fadl, Eman N Hosny
The present study aimed to investigate the protective and therapeutic effects of caffeine on rotenone-induced rat model of Parkinson's disease (PD). Rats were divided into control, PD model induced by rotenone (1.5 mg/kg intraperitoneally (i.p.) for 45 days), protected group injected with caffeine (30 mg/kg, i.p.) and rotenone for 45 days (during the development of PD model), and treated group injected with caffeine (30 mg/kg, i.p.) for 45 days after induction of PD model. The data revealed a state of oxidative and nitrosative stress in the midbrain and the striatum of animal model of PD as indicated from the increased lipid peroxidation and nitric oxide levels and the decreased reduced glutathione level and activities of glutathione-S-transferase and superoxide dismutase...
September 3, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28297037/safety-of-silicone-oil-removal-in-cases-of-gunshot-perforating-eye-injuries
#6
Hammouda Hamdy Ghoraba, Sameh Mohamed Elgouhary, Hosam Osman Mansour, Hitham Mamoun Abdel-Fattah, Mohamed Amin Heikal, Emad Mohamed Elgemaey
BACKGROUND AND OBJECTIVE: To evaluate the feasibility and safety of silicone oil (SO) removal in cases of gunshot perforating eye injuries (PEI). PATIENTS AND METHODS: A retrospective, consecutive, interventional study from medical records regarding cases of gunshot PEI during the periods of Egyptian political instability (January 2011 until December 2013). The main outcomes were to evaluate the feasibility of SO removal in cases of gunshot PEI and management of retinal detachment (RD) after SO removal in such cases...
March 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28295634/the-utility-of-salivary-testosterone-and-cortisol-concentration-measures-for-assessing-the-stress-responses-of-junior-athletes-during-a-sporting-competition
#7
Blair T Crewther, Zbigniew Obmiński, Joanna Orysiak, Emad A S Al-Dujaili
BACKGROUND: This study examined the utility of salivary testosterone (T) and cortisol (C) concentration measures for assessing the acute stress responses of junior athletes during a sporting competition. METHODS: Paired capillary blood and saliva samples were taken from 71 junior athletes (45 males, 26 females) before and after a simulated Olympic weightlifting competition. The concentration measures of salivary T and C were referenced against blood total T (TT) and C (TC) concentrations...
March 13, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28295387/short-and-long-term-clinical-predictors-of-pharmacological-cardioversion-of-persistent-atrial-fibrillation-by-dofetilide-a-retrospective-cohort-study-of-160-patients
#8
Hafeez Ul Hassan Virk, Waqas T Qureshi, Nayani Makkar, Joseph Bastawrose, Nektarios Souvaliotis, Joshua Aziz, Emad Aziz
INTRODUCTION: Dofetilide is a class III antiarrhythmic prescribed to cardiovert persistent atrial fibrillation (AF) to sinus rhythm (SR). HYPOTHESIS: To determine the clinical predictors of cardioversion and readmission in persistent AF patients on dofetilide. METHODS: We analyzed 160 patients with persistent AF who were started on dofetilide and followed for 1 year. We examined age, sex, race, hypertension, diabetes, smoking, dyslipidemia, CAD, left ventricular ejection fraction (LVEF), creatinine, BMI and concomitant use of calcium channel blockers (CCB), β-blockers in a multivariable logistic regression model...
March 14, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28293966/anatomic-reconstruction-of-the-anterior-cruciate-ligament-of-the-knee-with-or-without-reconstruction-of-the-anterolateral-ligament
#9
Samir Abdulrazik Ibrahim, Emad Mureed Shohdy, Yousef Marwan, Sami Abdulghaffar Ramadan, Abdulrahman Khalid Almisfer, Mohammad Wagdy Mohammad, Wael Shoabe Abdulsattar, Shiref Khirat
BACKGROUND: Rotational instability of the knee remains an issue after anterior cruciate ligament (ACL) reconstruction. Hypothesis/Purpose: The purpose was to evaluate the subjective and objective outcomes of combined reconstruction of the ACL and anterolateral ligament (ALL) of the knee. The hypothesis was that favorable outcomes can be achieved with this surgical procedure compared with isolated anatomic reconstruction of the ACL. STUDY DESIGN: Randomized controlled trial; Level of evidence, 2...
February 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28289287/energy-transduction-and-alternating-access-of-the-mammalian-abc-transporter-p-glycoprotein
#10
Brandy Verhalen, Reza Dastvan, Sundarapandian Thangapandian, Yelena Peskova, Hanane A Koteiche, Robert K Nakamoto, Emad Tajkhorshid, Hassane S Mchaourab
ATP binding cassette (ABC) transporters of the exporter class harness the energy of ATP hydrolysis in the nucleotide-binding domains (NBDs) to power the energetically uphill efflux of substrates by a dedicated transmembrane domain (TMD). Although numerous investigations have described the mechanism of ATP hydrolysis and defined the architecture of ABC exporters, a detailed structural dynamic understanding of the transduction of ATP energy to the work of substrate translocation remains elusive. Here we used double electron-electron resonance and molecular dynamics simulations to describe the ATP- and substrate-coupled conformational cycle of the mouse ABC efflux transporter P-glycoprotein (Pgp; also known as ABCB1), which has a central role in the clearance of xenobiotics and in cancer resistance to chemotherapy...
March 13, 2017: Nature
https://www.readbyqxmd.com/read/28286237/retrospectively-supervised-click-decoder-calibration-for-self-calibrating-point-and-click-brain-computer-interfaces
#11
Beata Jarosiewicz, Anish A Sarma, Jad Saab, Brian Franco, Sydney S Cash, Emad N Eskandar, Leigh R Hochberg
Brain-computer interfaces (BCIs) aim to restore independence to people with severe motor disabilities by allowing control of acursor on a computer screen or other effectors with neural activity. However, physiological and/or recording-related nonstationarities in neural signals can limit long-term decoding stability, and it would be tedious for users to pause use of the BCI whenever neural control degrades to perform decoder recalibration routines. We recently demonstrated that a kinematic decoder (i.e. a decoder that controls cursor movement) can be recalibrated using data acquired during practical point-and-click control of the BCI by retrospectively inferring users' intended movement directions based on their subsequent selections...
March 8, 2017: Journal of Physiology, Paris
https://www.readbyqxmd.com/read/28275519/sildenafil-citrate-in-combination-with-tamsulosin-versus-tamsulosin-monotherapy-for-management-of-male-lower-urinary-tract-symptoms-due-to-benign-prostatic-hyperplasia-a-randomised-double-blind-placebo-controlled-trial
#12
Amr Fawzi, Mostafa Kamel, Emad Salem, Esam Desoky, Mohamed Omran, Hazem Elgalaly, Ahmed Sakr, Aref Maarouf, Salem Khalil
OBJECTIVE: To assess the additive effect of sildenafil citrate to tamsulosin in the treatment of lower urinary tract symptoms due to benign prostatic hyperplasia (LUTS/BPH) in men with or without erectile dysfunction (ED). PATIENTS AND METHODS: In all, 150 men with untreated LUTS/BPH with or without ED were randomised to receive sildenafil 25 mg once daily (OD) or placebo OD (night time) combined with tamsulosin 0.4 mg OD (day time) for 6 months. Changes from pre-treatment scores in International Prostate Symptom Score (IPSS), IPSS-quality of life (QoL) score, maximum urinary flow rate (Qmax), and the five-item version of the International Index of Erectile Function questionnaire (IIEF-5) were assessed at 3 and 6 months...
March 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/28275515/immediate-versus-delayed-shockwave-lithotripsy-for-inaccessible-stones-after-uncomplicated-percutaneous-nephrolithotomy
#13
Esam A E Desoky, Amr M Fawzi, Ahmed Sakr, Ahmed Eliwa, Ehab R El Sayed, Diab El Sayed, Asharf M S Shahin, Emad A Salem, Hussien M Kamel, Waleed Shabana, Mostafa Kamel
OBJECTIVE: To evaluate the efficacy and safety of immediate versus delayed shockwave lithotripsy (SWL) for inaccessible stones after uncomplicated percutaneous nephrolithotomy (PCNL). PATIENTS AND METHODS: Between December 2011 and June 2014, patients with residual inaccessible stones after uncomplicated PCNL were prospectively randomised into two treatment groups; Group I, immediate SWL and Group II, delayed SWL at 1 week after PCNL. Patients with residual stones of ⩾1...
March 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/28272508/amplified-centrosomes-and-mitotic-index-display-poor-concordance-between-patient-tumors-and-cultured-cancer-cells
#14
Karuna Mittal, Da Hoon Choi, Angela Ogden, Shashi Donthamsetty, Brian D Melton, Meenakshi V Gupta, Vaishali Pannu, Guilherme Cantuaria, Sooryanarayana Varambally, Michelle D Reid, Kristin Jonsdottir, Emiel A M Janssen, Mohammad A Aleskandarany, Ian O Ellis, Emad A Rakha, Padmashree C G Rida, Ritu Aneja
Centrosome aberrations (CA) and abnormal mitoses are considered beacons of malignancy. Cancer cell doubling times in patient tumors are longer than in cultures, but differences in CA between tumors and cultured cells are uncharacterized. We compare mitoses and CA in patient tumors, xenografts, and tumor cell lines. We find that mitoses are rare in patient tumors compared with xenografts and cell lines. Contrastingly, CA is more extensive in patient tumors and xenografts (~35-50% cells) than cell lines (~5-15%), although CA declines in patient-derived tumor cells over time...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28268550/surgical-fiducial-segmentation-and-tracking-for-pose-estimation-based-on-ultrasound-b-mode-images
#15
Lei Chen, Nathanael Kuo, Fereshteh Aalamifar, David Narrow, Devin Coon, Jerry Prince, Emad M Boctor
Doppler ultrasound is a non-invasive diagnostic tool for the quantitative measurement of blood flow. However, given that it provides velocity data that is dependent on the location and angle of measurement, repeat measurements to detect problems over time may require an expert to return to the same location. We therefore developed an image-guidance system based on ultrasound B-mode images that enables an inexperienced user to position the ultrasound probe at the same site repeatedly in order to acquire a comparable time series of Doppler readings...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268448/predicting-local-field-potentials-with-recurrent-neural-networks
#16
Louis Kim, Jacob Harer, Akshay Rangamani, James Moran, Philip D Parks, Alik Widge, Emad Eskandar, Darin Dougherty, Sang Peter Chin
We present a Recurrent Neural Network using LSTM (Long Short Term Memory) that is capable of modeling and predicting Local Field Potentials. We train and test the network on real data recorded from epilepsy patients. We construct networks that predict multi-channel LFPs for 1, 10, and 100 milliseconds forward in time. Our results show that prediction using LSTM outperforms regression when predicting 10 and 100 millisecond forward in time.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28264611/prevalence-and-diagnostic-accuracy-of-doppler-ultrasound-of-placenta-accreta-in-egypt
#17
Ahmed M Maged, Emad Salah, Hany Saad, Hadeer Meshaal, Ashraf Eldaly, Maha A Katta, Wesam S Deeb
OBJECTIVE: To assess the prevalence of placenta accreta among those with placenta implanted over CS scar and to evaluate the accuracy of Doppler ultrasound in diagnosis. METHODS: A cross sectional study included 100 patients with placenta previa anterior with at least one previous CS. Ultrasound and color Doppler was done to all participants and correlated with operative findings. RESULTS: There was a significant difference between accrete and non accrete group regarding maternal age (32...
March 6, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28258912/risk-stratification-and-pattern-of-cardiotoxicity-in-pediatric-ewing-sarcoma
#18
Emad Moussa, Manal Zamzam, Ahmed Kamel, Zeinab Salah, Iman Attia, Lina Gaber, Ranin Soliman, Sameera Ezzat
INTRODUCTION: Anthracycline chemotherapy contributes to improved outcomes in Ewing sarcoma; however, the most feared complication is cardiotoxicity. Echocardiograms were routinely used to monitor cardiac function after anthracycline treatment. Nevertheless, indices chosen to assess cardiac toxicity vary significantly among different centers, and no uniform protocol has been accepted as ideal. METHODS: This retrospective study included children with Ewing sarcoma treated at Children's Cancer Hospital Egypt over 4years...
February 28, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28254786/clinical-impact-of-tumor-dna-repair-expression-and-t-cell-infiltration-in-breast-cancers
#19
Andrew R Green, Mohammed A Aleskandarany, Reem Ali, Eleanor Grace Hodgson, Suha Atabani, Karen De Souza, Emad Rakha, Ian O Ellis, Srinivasan Madhusudan
Impaired DNA repair drives mutagenicity, which increases neoantigen load and immunogenicity. We investigated the expression of proteins involved in the DNA damage response (ATM, Chk2), double-strand break repair (BRCA1, BLM, WRN, RECQL4, RECQL5, TOPO2A, DNA-PKcs, Ku70/Ku80), nucleotide excision repair (ERCC1), base excision repair (XRCC1, pol β, FEN1, PARP1), and immune responses (CD8, PD-1, PD-L1, FOXP3) in 1269 breast cancers and validated our findings in an independent estrogen receptor (ER)- cohort (n = 279)...
March 2, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28254268/adipokinetic-hormone-activities-in-insect-body-infected-by-entomopathogenic-nematode
#20
Emad Ibrahim, Markéta Hejníková, Haq Abdul Shaik, David Doležel, Dalibor Kodrík
The role of adipokinetic hormone (AKH) in the firebug Pyrrhocoris apterus adults infected by the entomopathogenic nematode (EPN) Steinernema carpocapsae was examined in this study. It was found that co-application of EPN and AKH enhanced firebug mortality about 2.5 times within 24h (from 20 to 51% in EPN vs. EPN+AKH treatments), and resulted in metabolism intensification, as carbon dioxide production in firebugs increased about 2.1 and 1.6times compared to control- and EPN-treated insects, respectively. Accordingly, firebugs with reduced expression of AKH receptors showed a significantly lower mortality (by 1...
February 27, 2017: Journal of Insect Physiology
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