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JOURNAL ARTICLE
Khayam Naderi, Ashmal Jameel, Sancy Low, Vijay Wagh, Mani Bhogal, Ailsa Ritchie, Scott Robbie, Chris Hammond, Moin Mohamed, Nick Stanojcic, Elodie Azan, Lily Lai, Chris Hull, David O'Brart
No abstract text is available yet for this article.
April 10, 2024: Eye
#2
JOURNAL ARTICLE
Siân R Morgan, David P S O'Brart, Jinhai Huang, Keith M Meek, Sally Hayes
BACKGROUND: Corneal cross-linking (CXL) using riboflavin and ultraviolet-A light (UVA) is a treatment used to prevent progression of keratoconus. This ex vivo study assesses the impact on CXL effectiveness, as measured by tissue enzymatic resistance and confocal microscopy, of including a pre-UVA corneal surface rinse with balanced salt solution (BSS) as part of the epithelium-off treatment protocol. METHODS: Sixty-eight porcine eyes, after epithelial debridement, were assigned to six groups in three experimental runs...
February 28, 2024: Eye and Vision (London, England)
#3
JOURNAL ARTICLE
Nick Stanojcic, Christopher C Hull, Eduardo Mangieri, Nathan Little, David O'Brart
AIM: To assess the performance of a bespoke software for automated counting of intraocular lens (IOL) glistenings in slit-lamp images. METHODS: IOL glistenings from slit-lamp-derived digital images were counted manually and automatically by the bespoke software. The images of one randomly selected eye from each of 34 participants were used as a training set to determine the threshold setting that gave the best agreement between manual and automatic grading. A second set of 63 images, selected using randomised stratified sampling from 290 images, were used for software validation...
2023: International Journal of Ophthalmology
#4
JOURNAL ARTICLE
Nick Stanojcic, David O'Brart, Chris Hull, Vijay Wagh, Elodie Azan, Mani Bhogal, Scott Robbie, Ji-Peng Olivia Li
AIM: To evaluate corneal astigmatic outcomes of femtosecond laser-assisted arcuate keratotomies (FAKs) combined with femtosecond-laser assisted cataract surgery (FLACS) over 12mo follow-up. METHODS: Totally 145 patients with bilateral cataracts and no ocular co-morbidities were recruited to a single-centre, single-masked, prospective randomized controlled trial (RCT) comparing two monofocal hydrophobic acrylic intraocular lenses. Eyes with corneal astigmatism (CA) of >0...
2023: International Journal of Ophthalmology
#5
REVIEW
Akshay Narayan, Jennifer R Evans, David O'Brart, Catey Bunce, Daniel M Gore, Alexander C Day
BACKGROUND: Cataract is the leading cause of blindness in the world and, as such, cataract surgery is one of the most commonly performed operations globally. Surgical techniques have changed dramatically over the past half century with associated improvements in outcomes and safety. Femtosecond lasers can be used to perform the key steps in cataract surgery, such as corneal incisions, lens capsulotomy and fragmentation. The potential advantage of femtosecond laser-assisted cataract surgery (FLACS) is greater precision and reproducibility of these steps compared to manual techniques...
June 23, 2023: Cochrane Database of Systematic Reviews
#6
JOURNAL ARTICLE
Ashmal Jameel, Lucia Dong, Chun Fung Jeffrey Lam, Hana Mahmood, Khayam Naderi, Sancy Low, Elodie Azan, Seema Verma, Scott Robbie, Mani Bhogal, David O'Brart
OBJECTIVES: To investigate patient understanding of, and attitudes to, premium (toric, extended depth of focus/multifocal) intraocular lenses (premIOLs) in public health sector patients undergoing cataract surgery (CS) in the UK. METHODS: A 12 question survey with Likert scale questions was designed, to assess patient attitudes to post-operative spectacle dependence, refractive target and desirability of spectacle independence whilst considering possible complications of dysphotopsias and need for premIOL exchange/adjustment...
June 24, 2023: Eye
#7
JOURNAL ARTICLE
Nick Stanojcic, Chris Hull, David O'Brart
We read with interest your article describing a new objective method for evaluating glistenings in intraocular lenses (IOLs) in vivo [...].
May 26, 2023: Journal of Clinical Medicine
#8
JOURNAL ARTICLE
Khayam Naderi, Chun Fung Jeffrey Lam, Sancy Low, Mani Bhogal, Ashmal Jameel, Korina Theodoraki, Lily Lai, Luis Onrubia Garcia, Harry Roberts, Scott Robbie, David O'Brart
BACKGROUND: To compare productivity of National Health Service cataract lists performing unilateral cataract (UC) surgery vs Immediate Sequential Bilateral Cataract Surgery (ISBCS). METHODS: Five 4-hour lists with ISBCS cases and five with UC were observed using time and motion studies (TMS). Individual tasks and timings of each staff member in theatre was recorded by two observers. All operations were performed by consultant surgeons under local anaesthesia (LA)...
June 5, 2023: Eye
#9
JOURNAL ARTICLE
Sally Hayes, Philip Jaycock, Nicholas Rees, Francisco C Figueiredo, David P S O'Brart, Keith M Meek
OBJECTIVE: To provide an insight into trends in corneal cross-linking (CXL) practice in the UK, including criteria for progression of corneal ectasia, identification of patients for CXL, the CXL procedure itself and post-operative management. METHODS: All ophthalmologist members of the UK Cross-linking (UK-CXL) Consortium were invited to complete an online survey about CXL practice for the year 2019. The data collected was anonymised by site and analysed with descriptive statistics...
December 20, 2022: Eye
#10
JOURNAL ARTICLE
Tomas Mickevicius, Andrew E Pink, Maninder Bhogal, David O'Brart, Scott J Robbie
Emerging monoclonal antibody therapies are assuming greater importance in the management of severe and refractory forms of immunity-driven and oncological disorders. However, some have been found to induce adverse ocular events (AOEs) leading to discontinuation of treatment or additional multidisciplinary management. We present the current knowledge concerning AOEs associated with 3 monoclonal antibody therapies: dupilumab, tralokinumab, and belantamab mafodotin. We examine the manifestations of their AOEs, proposed pathophysiological mechanisms, and current treatment recommendations...
December 16, 2022: Cornea
#11
JOURNAL ARTICLE
Korina Theodoraki, Khayam Naderi, Chun Fung Jeffrey Lam, Jit Kai Tan, Ashmal Jameel, Lily Lai, Luis Onrubia Garcia, Sancy Low, Mani Bhogal, Scott Robbie, David O'Brart
BACKGROUND/OBJECTIVES: During the COVID-19, elective cataract surgery (CS) was significantly curtailed. We investigated whether consequent reduction of micro-surgical skills practice might lead to higher operative complications. METHODS: Single-centre, electronic note review of consecutive patients undergoing CS during three periods: 1st February 2019 to 13th January 2020 (P1) prior to pandemic; 3rd June 2020 to 11th January 2021 after 1st lockdown (P2); and 25th January to 30th July 2021 (P3) after/during second lockdown...
February 3, 2022: Eye
#12
JOURNAL ARTICLE
Nick Stanojcic, Christopher Hull, David P S O'Brart
No abstract text is available yet for this article.
November 10, 2021: European Journal of Ophthalmology
#13
JOURNAL ARTICLE
Laura Maubon, Paul Nderitu, David P S O'Brart
OBJECTIVES: Cataract surgeons may periodically take time away from operating which can lead to skills fade. There is a paucity of research investigating the experiences of returning cataract surgeons and how different individual circumstances impact on their return. Our aim was to investigate the subjective experiences of UK ophthalmologists simultaneously returning to surgery following the nationwide elective surgical hiatus due to the Covid-19 pandemic. METHODS: An online survey was nationally distributed between 01/09/2020 and 29/10/2020 to registered UK ophthalmologists...
August 6, 2021: Eye
#14
REVIEW
Shruti Chandra, Sobha Sivaprasad, Paul G Ursell, Khayam Naderi, David O'Brart, Amar Alwitry, Zahra Ashena, Mayank A Nanavaty
The aim of this review was to discuss frequently encountered themes such as cataract surgery in presence of age-related macular degeneration (AMD), dementia, Immediate Sequential Bilateral Cataract Surgery (ISBCS), discussing non-standard intraocular lens (IOL) options during consultation in the National Health Services (NHS) and the choice of the biometric formulae based on axial length. Individual groups of authors worked independently on each topic. We found that cataract surgery does improve visual acuity in AMD patients but the need for cataract surgery should be individualised...
September 2021: Eye
#15
MULTICENTER STUDY
Alison J Hardcastle, Petra Liskova, Yelena Bykhovskaya, Bennet J McComish, Alice E Davidson, Chris F Inglehearn, Xiaohui Li, Hélène Choquet, Mahmoud Habeeb, Sionne E M Lucas, Srujana Sahebjada, Nikolas Pontikos, Karla E Rojas Lopez, Anthony P Khawaja, Manir Ali, Lubica Dudakova, Pavlina Skalicka, Bart T H Van Dooren, Annette J M Geerards, Christoph W Haudum, Valeria Lo Faro, Abi Tenen, Mark J Simcoe, Karina Patasova, Darioush Yarrand, Jie Yin, Salina Siddiqui, Aine Rice, Layal Abi Farraj, Yii-Der Ida Chen, Jugnoo S Rahi, Ronald M Krauss, Elisabeth Theusch, Jac C Charlesworth, Loretta Szczotka-Flynn, Carmel Toomes, Magda A Meester-Smoor, Andrea J Richardson, Paul A Mitchell, Kent D Taylor, Ronald B Melles, Anthony J Aldave, Richard A Mills, Ke Cao, Elsie Chan, Mark D Daniell, Jie Jin Wang, Jerome I Rotter, Alex W Hewitt, Stuart MacGregor, Caroline C W Klaver, Wishal D Ramdas, Jamie E Craig, Sudha K Iyengar, David O'Brart, Eric Jorgenson, Paul N Baird, Yaron S Rabinowitz, Kathryn P Burdon, Chris J Hammond, Stephen J Tuft, Pirro G Hysi
Keratoconus is characterised by reduced rigidity of the cornea with distortion and focal thinning that causes blurred vision, however, the pathogenetic mechanisms are unknown. It can lead to severe visual morbidity in children and young adults and is a common indication for corneal transplantation worldwide. Here we report the first large scale genome-wide association study of keratoconus including 4,669 cases and 116,547 controls. We have identified significant association with 36 genomic loci that, for the first time, implicate both dysregulation of corneal collagen matrix integrity and cell differentiation pathways as primary disease-causing mechanisms...
March 1, 2021: Communications Biology
#16
JOURNAL ARTICLE
Sancy Low, John Tran, Catherine McGurk, Ayushi Gupta, Harry W Roberts, David O'Brart
No abstract text is available yet for this article.
December 1, 2020: Current Eye Research
#17
RANDOMIZED CONTROLLED TRIAL
Nick Stanojcic, Harry Roberts, Vijay Wagh, Bruno Zuberbuhler, David O'Brart
BACKGROUND/OBJECTIVES: To compare visual and refractive outcomes of monofocal intraocular lenses (IOLs) with limbal relaxing incisions (LRI) with 'off-the-shelf' use of toric IOLs (TIOLs), with a fixed 2-dioptre cylinder (DC) correction, for cataract patients with pre-existing corneal astigmatism in a public-sector setting. SUBJECTS/METHODS: Seventy-seven patients (77 eyes, first treated eye) with visually significant cataract and pre-operative corneal astigmatism ≥2...
October 2020: Eye
#18
JOURNAL ARTICLE
Khayam Naderi, Laura Maubon, Ashmal Jameel, Darshak S Patel, Jack Gormley, Vishal Shah, Lily Lai, Sancy Low, Seema Verma, Scott Robbie, Mani Bhogal, David O'Brart
No abstract text is available yet for this article.
July 24, 2020: Eye
#19
JOURNAL ARTICLE
Nick Stanojcic, Harry William Roberts, Vijay K Wagh, Ji-Peng Olivia Li, Khayam Naderi, David P O'Brart
AIMS: To report 12-month outcomes of randomised controlled trial comparing conventional phacoemulsification surgery (CPS) with femtosecond laser-assisted cataract surgery (FLACS). METHODS: This was a single-centre, prospective single-masked randomised case-controlled trial. Four hundred patients were randomised to CPS or FLACS with the LenSx platform (Alcon Laboratories Inc.). Visual acuity, refraction, central corneal thickness, endothelial cell loss (ECL), adverse events and quality of life outcomes, using EuroQOL 5-dimensions (EQ-5D-3 L) and cataract surgery patient-reported outcome measures (PROMs) questionnaires (Cat-PROM5), were recorded...
July 22, 2020: British Journal of Ophthalmology
#20
JOURNAL ARTICLE
David P O'Brart, Harry Roberts, Khayam Naderi, Jack Gormley
Objective: To test a hypothesis that operating room (OR) productivity in the National Health Service (NHS) can be improved with the introduction of immediately sequential bilateral cataract surgery (ISBCS). Methods and analysis: Previously published time and motion data of 140 unilateral cataract surgeries conducted at five different NHS locations were reanalysed to construct a hypothetical model where only ISBCS (±one unilateral case) were conducted while maintaining time durations of all key tasks previously studied...
2020: BMJ Open Ophthalmology
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