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David O'brart

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https://www.readbyqxmd.com/read/27765574/an-investigation-into-corneal-enzymatic-resistance-following-epithelium-off-and-epithelium-on-corneal-cross-linking-protocols
#1
Nada H Aldahlawi, Sally Hayes, David P S O'Brart, Naomi D O'Brart, Keith M Meek
The aim of this study was to investigate corneal enzymatic resistance following epithelium off and on riboflavin/UVA cross-linking (CXL). One hundred and fourteen porcine eyes were divided into four non-irradiated control groups and seven CXL groups. The latter comprised; (i) epithelium-off, 0.1% iso-osmolar riboflavin, 9 mW UVA irradiation for 10 min, (ii) disrupted epithelium, 0.1% hypo-osmolar riboflavin, 9 mW UVA for 10 min, (iii) epithelium-on, 0.25% hypo-osmolar riboflavin with 0.01% benzylalkonium chloride (BACS), 9 mW UVA for 10 min, (iv) epithelium-on, 5 min iontophoresis at 0...
October 17, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27304600/transepithelial-corneal-cross-linking-using-an-enhanced-riboflavin-solution
#2
Zisis Gatzioufas, Frederik Raiskup, David O'Brart, Eberhard Spoerl, Georgios D Panos, Farhad Hafezi
PURPOSE: To assess the efficacy of a modified high concentration riboflavin solution containing benzalkonium chloride 0.01% for transepithelial corneal cross-linking (CXL). METHODS: In this prospective, interventional multicenter cohort study, 26 eyes of 26 patients with documented progressive keratoconus who underwent transepithelial CXL were included. Follow-up at 6 and 12 months postoperatively included slit-lamp examination, uncorrected and corrected distance visual acuity (logMAR), maximum keratometry (Kmax), and corneal pachymetry (corneal thinnest point) as determined by Scheimpflug imaging...
June 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27255248/sixteen-year-follow-up-of-hyperopic-laser%C3%A2-in-situ-keratomileusis
#3
Reena Dave, David P S O'Brart, Vijay K Wagh, Wei S Lim, Parul Patel, Jennifer Lee, John Marshall
PURPOSE: To assess the long-term efficacy and safety of hyperopic laser in situ keratomileusis (LASIK). SETTING: Department of Ophthalmology, St. Thomas' Hospital, London, United Kingdom. DESIGN: Prospective cohort study. METHODS: Hyperopic LASIK was performed using a mechanical microkeratome, an optical zone of 6.5 mm, and a blend zone of 1.5 mm. Simple hyperopia was treated. RESULTS: The mean patient age was 51...
May 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27046119/enzymatic-resistance-of-corneas-crosslinked-using-riboflavin-in-conjunction-with-low-energy-high-energy-and-pulsed-uva-irradiation-modes
#4
Nada H Aldahlawi, Sally Hayes, David P S O'Brart, Alina Akhbanbetova, Stacy L Littlechild, Keith M Meek
PURPOSE: To investigate the effect of various riboflavin/ultraviolet light (UVA) crosslinking (CXL) protocols on corneal enzymatic resistance. METHODS: A total of 66 enucleated porcine eyes, with the corneal epithelium removed, were divided into 6 groups. Group 1 remained untreated. Groups 2 to 6 received riboflavin/dextran for 30 minutes. Group 3 underwent standard CXL (SCXL) with 3 mW/cm(2) UVA for 30 minutes (total energy dose 5.4 J/cm(2)). Groups 4 and 5 underwent high intensity CXL (HCXL) using 30 mW/cm(2) UVA for 3 minutes (5...
April 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27026451/eighteen-year-follow-up-of-hyperopic-photorefractive-keratectomy
#5
Vijay K Wagh, Reena Dave, David P S O'Brart, Wei S Lim, Parul Patel, Connan Tam, Jennifer Lee, John Marshall
PURPOSE: To investigate the long-term efficacy of hyperopic photorefractive keratectomy (PRK). SETTING: University Hospital, London, United Kingdom. DESIGN: Prospective case series. METHODS: Patients with a follow-up of 18 years ± 0.7 (SD) attended for examination. All had spherical corrections with a 6.5 mm optical zone and 1.5 mm blend zone. RESULTS: Twenty-five patients (45 eyes) were included...
February 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/26603408/standard-versus-accelerated-riboflavin-ultraviolet-corneal-collagen-crosslinking-resistance-against-enzymatic-digestion
#6
Nada H Aldahlawi, Sally Hayes, David P S O'Brart, Keith M Meek
PURPOSE: To examine the effect of standard and accelerated corneal collagen crosslinking (CXL) on corneal enzymatic resistance. SETTING: School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom. DESIGN: Experimental study. METHODS: Sixty-six enucleated porcine eyes (with corneal epithelium removed) were assigned to 6 groups. Group 1 remained untreated, group 2 received dextran eyedrops, and groups 3 to 6 received riboflavin/dextran eyedrops...
September 2015: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/26307513/corneal-cross-linking-to-halt-the-progression-of-keratoconus-and-corneal-ectasia-seven-year-follow-up
#7
David P S O'Brart, Parul Patel, Gerassimos Lascaratos, Vijay K Wagh, Connan Tam, Jennifer Lee, Naomi A O'Brart
PURPOSE: To determine long-term efficacy and safety of riboflavin/ultraviolet A corneal cross-linking (CXL). DESIGN: Prospective cohort study. METHODS: Thirty-six patients (36 eyes) who underwent epithelium-off CXL at a University Hospital (Guy's and St Thomas' National Health Service Foundation Trust) 6-8 years previously were examined. The main outcome measures were refractive error, visual acuity, corneal topographic keratometry, ultrasonic pachymetry, and topography-derived corneal wavefront...
December 2015: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/26230765/transepithelial-riboflavin-absorption-in-an-ex-vivo-rabbit-corneal-model
#8
Daniel M Gore, David O'Brart, Paul French, Chris Dunsby, Bruce D Allan
PURPOSE: To measure depth-specific riboflavin concentrations in corneal stroma using two-photon fluorescence microscopy and compare commercially available transepithelial corneal collagen cross-linking (CXL) protocols. METHODS: Transepithelial CXL riboflavin preparations--MedioCross TE, Ribocross TE, Paracel plus VibeX Xtra, and iontophoresis with Ricrolin+--were applied to the corneal surface of fresh postmortem rabbit eyes in accordance with manufacturers' recommendations for clinical use...
July 2015: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/26210054/idiopathic-stromal-keratitis-resembling-central-toxic-keratopathy
#9
Vijay Kumar Wagh, Laura de Benito-Llopis, David P S O'Brart
UNLABELLED: A 28-year-old previously emmetropic woman presented with a 2-day history of bilateral photophobia and blurred vision. She had no history of corneal surgery or contact lens use. Snellen uncorrected distance visual acuity (UDVA) was 6/12 bilaterally. Bilateral anterior stromal infiltration of the central cornea was seen, with no overlying epithelial defect and intact sensation. There was a marked hyperopic shift, central corneal thinning, and associated keratometric flattening...
July 2015: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/26088738/isolated-dislocation-of-a-supplementary-sulcus-pseudophakic-intraocular-lens
#10
David P S O'Brart, Nashila Hirji
UNLABELLED: We report the case of a woman with pseudoexfoliation who presented with a hyperopic refractive surprise and uncontrolled intraocular pressure (IOP) following cataract surgery and in-the-bag intraocular lens (IOL) implantation in the left eye. Trabeculectomy was performed, and a supplementary (piggyback) sulcus IOL was inserted. At 5 years, the uncorrected distance visual acuity (UDVA) was 20/16 and the IOP was less than 21 mm Hg. Following head trauma, the patient experienced blurred vision...
June 2015: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/25467133/eighteen-year-follow-up-of-excimer-laser-photorefractive-keratectomy
#11
Zaid Shalchi, David P S O'Brart, Robert J McDonald, Parul Patel, Timothy J Archer, John Marshall
PURPOSE: To evaluate the long-term efficacy of photorefractive keratectomy (PRK). SETTING: University Hospital, London, United Kingdom. DESIGN: Prospective case series. METHODS: One eye of patients who had PRK 18 years previously was examined. All had myopic corrections with a 6.0 mm optical zone. RESULTS: Forty-six patients were examined. The mean preoperative spherical equivalent (SE) refractive error was -4...
January 2015: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/25425305/high-heritability-of-posterior-corneal-tomography-as-measured-by-scheimpflug-imaging-in-a-twin-study
#12
Omar A Mahroo, Mohammed Oomerjee, Katie M Williams, David P S O'Brart, Christopher J Hammond
PURPOSE: Anterior corneal curvature shows significant heritability. Scheimpflug imaging also permits assessment of posterior tomography. We estimated heritability of posterior and anterior tomographic parameters. METHODS: Oculus Pentacam images were obtained in twins from the TwinsUK cohort. Mean anterior and posterior radii of curvature (right cornea) were compared within twin pairs, and heritability calculated (maximum likelihood structural equation modeling, using OpenMx package)...
November 25, 2014: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/25000866/corneal-collagen-cross-linking-a-review
#13
REVIEW
David P S O'Brart
The aim was to review the published literature on corneal collagen cross-linking. The emphasis was on the seminal publications, systemic reviews, meta-analyses and randomized controlled trials. Where such an evidence did not exist, selective large series cohort studies, case controlled studies and case series with follow-up preferably greater than 12 months were included. Riboflavin/Ultraviolet A (UVA) corneal collagen cross-linking appears to be the first treatment modality to halt the progression of keratoconus and other corneal ectatic disorders with improvement in visual, keratometric and topographic parameters documented by most investigators...
July 2014: Journal of Optometry
https://www.readbyqxmd.com/read/24973609/twenty-year-follow-up-of-a-randomized-prospective-clinical-trial-of-excimer-laser-photorefractive-keratectomy
#14
RANDOMIZED CONTROLLED TRIAL
David P S O'Brart, Zaid Shalchi, Robert J McDonald, Parul Patel, Timothy J Archer, John Marshall
PURPOSE: To investigate the 20-year efficacy and safety of photorefractive keratectomy (PRK). DESIGN: Long-term observational case series. METHODS: In the setting of a university hospital, a study population of 42 patients (42 eyes) who had, as part of a randomized prospective trial, undergone PRK 20 years previously were studied. All had received -3.0 or -6.0 diopter (D) corrections with either 5.0 or 6.0 mm optical zones or a multizone treatment...
October 2014: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/24644056/two-photon-fluorescence-microscopy-of-corneal-riboflavin-absorption
#15
Daniel M Gore, Anca Margineanu, Paul French, David O'Brart, Chris Dunsby, Bruce D Allan
PURPOSE: To correct for attenuation in two-photon fluorescence (TPF) measurements of riboflavin absorption in porcine corneas. METHODS: Two-photon fluorescence imaging of riboflavin was performed using excitation at a wavelength of 890 nm, with fluorescence signal detected between 525 and 650 nm. TPF signal attenuation was demonstrated by imaging from either side of a uniformly soaked corneoscleral button. To overcome this attenuation, a reservoir of dextran-free 0...
April 2014: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/23656608/excimer-laser-surface-ablation-a-review-of-recent-literature
#16
REVIEW
David P S O'Brart
The aim was to review the recently published literature on excimer laser surface ablation procedures, including photorefractive keratectomy (PRK), laser sub-epithelial keratomileusis (LASEK), microkeratome-assisted PRK (epi-LASIK) and trans-epithelial (laser-assisted) PRK, to help elucidate where and how surface ablation may best fit into current refractive surgical practice. The emphasis was on publications within the last three years and included systemic reviews, meta-analyses and randomised controlled trials...
January 2014: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/23579606/bilateral-descemet-membrane-detachment-following-cataract-surgery
#17
Zaid Shalchi, David P S O'Brart, Luca Ilari
No abstract text is available yet for this article.
April 2013: JAMA Ophthalmology
https://www.readbyqxmd.com/read/23385632/long-term-follow-up-of-riboflavin-ultraviolet-a-370-nm-corneal-collagen-cross-linking-to-halt-the-progression-of-keratoconus
#18
David P S O'Brart, Tsong Q Kwong, Parul Patel, Robert J McDonald, Naomi A O'Brart
AIMS: To determine long-term efficacy of riboflavin/ultraviolet A corneal cross-linking (CXL). METHODS: Thirty patients (30 eyes) who had undergone CXL following epithelial removal 4-6 years previously were examined. RESULTS: At 1-year mean, spherical equivalent error (SEQ) increased by +0.72 dioptres (D) (p<0.002), corrected distance visual acuity (CDVA) improved (p<0.005), mean simulated keratometry (Sim K) reduced by 0.27D (p<0...
April 2013: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/22775539/pterygium-after-hyperopic-laser-assisted-sub-epithelial-keratomileusis-lasek
#19
David P S O'Brart, Katherine Williams
A 61-year-old Caucasian woman with hyperopia presented for laser refractive surgery. She had healthy eyes with the exception of a less than 0.5 mm Salzmann's nodule at 5 o'clock near the limbus of the right eye. She underwent bilateral hyperopic laser-assisted sub-epithelial keratomileusis (LASEK) combined with removal of the Salzmann's nodule. At six months, she was emmetropic with unaided vision of 6/6; however, at 10 months, she noticed a reduction of acuity in her right eye and was found to have a pterygium at 5 o'clock, encroaching 3...
May 2013: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/22520311/evaluation-of-transepithelial-stromal-riboflavin-absorption-with-enhanced-riboflavin-solution-using-spectrophotometry
#20
Tariq A Alhamad, David P S O'Brart, Naomi A L O'Brart, Keith M Meek
PURPOSE: To assess transepithelial stromal riboflavin absorption with an enhanced riboflavin solution (riboflavin 0.1%, 15% dextran T500 with trometamol (Tris-[hydroxymethyl]aminomethane) and sodium ethylenediaminetetraacetic acid by analyzing light-transmission properties of ex vivo rabbit corneas. SETTING: School of Optometry and Vision Sciences, Cardiff, Wales. DESIGN: Experimental study. METHODS: The enhanced riboflavin drops (Ricrolin TE) were applied every 3 minutes for 1 hour to 12 corneas (4 with intact epithelium, 4 with superficial scratches, 4 with 8...
May 2012: Journal of Cataract and Refractive Surgery
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