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David O'brart

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https://www.readbyqxmd.com/read/29675396/comment-on-post-photorefractive-keratectomy-corneal-ectasia
#1
David O'Brart
No abstract text is available yet for this article.
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29490342/an-investigation-of-the-effects-of-riboflavin-concentration-on-the-efficacy-of-corneal-cross-linking-using-an-enzymatic-resistance-model-in-porcine-corneas
#2
Naomi A L O'Brart, David P S O'Brart, Nada H Aldahlawi, Sally Hayes, Keith M Meek
Purpose: To investigate riboflavin concentration on enzymatic resistance following corneal cross-linking (CXL). Methods: Ninety-six porcine eyes were divided into five groups in two treatment runs. Group 1 remained untreated. Group 2 received riboflavin 0.05%, group 3 riboflavin 0.1%, group 4 riboflavin 0.2%, and group 5 riboflavin 0.3%. Treated eyes underwent CXL with ultraviolet A at 9 mW/cm2 for 10 minutes. Eight-millimeter discs from each cornea were submerged in pepsin digest solution...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29436401/evaluation-of-a-hub-and-spoke-model-for-the-delivery-of-femtosecond-laser-assisted-cataract-surgery-within-the-context-of-a-large-randomised-controlled-trial
#3
Harry W Roberts, Vijay K Wagh, Isabella J M Mullens, Simone Borsci, Melody Z Ni, David P S O'Brart
AIMS: To test a hypothesis that cataract operating room (OR) productivity can be improved with a femtosecond laser (FL) using a hub-and-spoke model and whether any increase in productivity can offset additional costs relating to the FL. METHODS: 400 eyes of 400 patients were enrolled in a randomised-controlled trial comparing FL-assisted cataract surgery (FLACS) with conventional phacoemulsification surgery (CPS). 299 of 400 operations were performed on designated high-volume theatre lists (FLACS=134, CPS=165), where a hub-and-spoke FLACS model (1×FL, 2×ORs=2:1) was compared with independent CPS theatre lists...
February 7, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29175969/time-and-motion-studies-of-national-health-service-cataract-theatre-lists-to-determine-strategies-to-improve-efficiency
#4
Harry W Roberts, James Myerscough, Simone Borsci, Melody Ni, David P S O'Brart
AIM: To provide a quantitative assessment of cataract theatre lists focusing on productivity and staffing levels/tasks using time and motion studies. METHODS: National Health Service (NHS) cataract theatre lists were prospectively observed in five different institutions (four NHS hospitals and one private hospital). Individual tasks and their timings of every member of staff were recorded. Multiple linear regression analyses were performed to investigate possible associations between individual timings and tasks...
November 24, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28532974/cost-effectiveness-analysis-of-corneal-collagen-crosslinking-for-progressive-keratoconus
#5
Daniel A Godefrooij, Marie-Josee J Mangen, Elsie Chan, David P S O'Brart, Saskia M Imhof, G Ardine de Wit, Robert P L Wisse
PURPOSE: To evaluate the cost effectiveness of corneal collagen crosslinking (CXL) for progressive keratoconus from the healthcare payer's perspective. DESIGN: A probabilistic Markov-type model using data from published clinical trials and cohort studies. PARTICIPANTS: Two identical cohorts, each comprising 1000 virtual patients with progressive bilateral keratoconus, were modeled; one cohort underwent CXL and the other cohort received no intervention...
October 2017: Ophthalmology
https://www.readbyqxmd.com/read/28393048/comment-on-profitability-analysis-of-a-femtosecond-laser-system-for-cataract-surgery-using-a-fuzzy-logic-approach
#6
Harry William Roberts, Melody Zhifang Ni, David Phillip S O'Brart
No abstract text is available yet for this article.
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28009397/corneal-collagen-crosslinking-for-corneal-ectasias-a-review
#7
REVIEW
David P S O'Brart
PURPOSE: To review the published literature on corneal collagen crosslinking (CXL). METHODS: Importance has been placed on seminal publications, systemic reviews, meta-analyses, and randomized controlled clinical trials. Where such evidence was not available, cohort studies, case-controlled studies, and case series with follow-up greater than 12 months were examined. RESULTS: Corneal collagen crosslinking with riboflavin and ultraviolet A (UVA) 370 nm radiation appears to be capable of arresting the progression of ectatic corneal disorders, with most studies reporting significant improvements in visual, keratometric, and topographic measurements...
May 11, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/27765574/an-investigation-into-corneal-enzymatic-resistance-following-epithelium-off-and-epithelium-on-corneal-cross-linking-protocols
#8
Nada H Aldahlawi, Sally Hayes, David P S O'Brart, Naomi D O'Brart, Keith M Meek
The aim of this study was to investigate corneal enzymatic resistance following epithelium off and on riboflavin/UVA cross-linking (CXL). One hundred and fourteen porcine eyes were divided into four non-irradiated control groups and seven CXL groups. The latter comprised; (i) epithelium-off, 0.1% iso-osmolar riboflavin, 9 mW UVA irradiation for 10 min, (ii) disrupted epithelium, 0.1% hypo-osmolar riboflavin, 9 mW UVA for 10 min, (iii) epithelium-on, 0.25% hypo-osmolar riboflavin with 0.01% benzylalkonium chloride (BACS), 9 mW UVA for 10 min, (iv) epithelium-on, 5 min iontophoresis at 0...
December 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27304600/transepithelial-corneal-cross-linking-using-an-enhanced-riboflavin-solution
#9
MULTICENTER STUDY
Zisis Gatzioufas, Frederik Raiskup, David O'Brart, Eberhard Spoerl, Georgios D Panos, Farhad Hafezi
PURPOSE: To assess the efficacy of a modified high concentration riboflavin solution containing benzalkonium chloride 0.01% for transepithelial corneal cross-linking (CXL). METHODS: In this prospective, interventional multicenter cohort study, 26 eyes of 26 patients with documented progressive keratoconus who underwent transepithelial CXL were included. Follow-up at 6 and 12 months postoperatively included slit-lamp examination, uncorrected and corrected distance visual acuity (logMAR), maximum keratometry (Kmax), and corneal pachymetry (corneal thinnest point) as determined by Scheimpflug imaging...
June 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27255248/sixteen-year-follow-up-of-hyperopic-laser%C3%A2-in-situ-keratomileusis
#10
Reena Dave, David P S O'Brart, Vijay K Wagh, Wei S Lim, Parul Patel, Jennifer Lee, John Marshall
PURPOSE: To assess the long-term efficacy and safety of hyperopic laser in situ keratomileusis (LASIK). SETTING: Department of Ophthalmology, St. Thomas' Hospital, London, United Kingdom. DESIGN: Prospective cohort study. METHODS: Hyperopic LASIK was performed using a mechanical microkeratome, an optical zone of 6.5 mm, and a blend zone of 1.5 mm. Simple hyperopia was treated. RESULTS: The mean patient age was 51...
May 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27046119/enzymatic-resistance-of-corneas-crosslinked-using-riboflavin-in-conjunction-with-low-energy-high-energy-and-pulsed-uva-irradiation-modes
#11
Nada H Aldahlawi, Sally Hayes, David P S O'Brart, Alina Akhbanbetova, Stacy L Littlechild, Keith M Meek
PURPOSE: To investigate the effect of various riboflavin/ultraviolet light (UVA) crosslinking (CXL) protocols on corneal enzymatic resistance. METHODS: A total of 66 enucleated porcine eyes, with the corneal epithelium removed, were divided into 6 groups. Group 1 remained untreated. Groups 2 to 6 received riboflavin/dextran for 30 minutes. Group 3 underwent standard CXL (SCXL) with 3 mW/cm(2) UVA for 30 minutes (total energy dose 5.4 J/cm(2)). Groups 4 and 5 underwent high intensity CXL (HCXL) using 30 mW/cm(2) UVA for 3 minutes (5...
April 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27026451/eighteen-year-follow-up-of-hyperopic-photorefractive-keratectomy
#12
Vijay K Wagh, Reena Dave, David P S O'Brart, Wei S Lim, Parul Patel, Connan Tam, Jennifer Lee, John Marshall
PURPOSE: To investigate the long-term efficacy of hyperopic photorefractive keratectomy (PRK). SETTING: University Hospital, London, United Kingdom. DESIGN: Prospective case series. METHODS: Patients with a follow-up of 18 years ± 0.7 (SD) attended for examination. All had spherical corrections with a 6.5 mm optical zone and 1.5 mm blend zone. RESULTS: Twenty-five patients (45 eyes) were included...
February 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/26603408/standard-versus-accelerated-riboflavin-ultraviolet-corneal-collagen-crosslinking-resistance-against-enzymatic-digestion
#13
Nada H Aldahlawi, Sally Hayes, David P S O'Brart, Keith M Meek
PURPOSE: To examine the effect of standard and accelerated corneal collagen crosslinking (CXL) on corneal enzymatic resistance. SETTING: School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom. DESIGN: Experimental study. METHODS: Sixty-six enucleated porcine eyes (with corneal epithelium removed) were assigned to 6 groups. Group 1 remained untreated, group 2 received dextran eyedrops, and groups 3 to 6 received riboflavin/dextran eyedrops...
September 2015: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/26307513/corneal-cross-linking-to-halt-the-progression-of-keratoconus-and-corneal-ectasia-seven-year-follow-up
#14
David P S O'Brart, Parul Patel, Gerassimos Lascaratos, Vijay K Wagh, Connan Tam, Jennifer Lee, Naomi A O'Brart
PURPOSE: To determine long-term efficacy and safety of riboflavin/ultraviolet A corneal cross-linking (CXL). DESIGN: Prospective cohort study. METHODS: Thirty-six patients (36 eyes) who underwent epithelium-off CXL at a University Hospital (Guy's and St Thomas' National Health Service Foundation Trust) 6-8 years previously were examined. The main outcome measures were refractive error, visual acuity, corneal topographic keratometry, ultrasonic pachymetry, and topography-derived corneal wavefront...
December 2015: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/26230765/transepithelial-riboflavin-absorption-in-an-ex-vivo-rabbit-corneal-model
#15
Daniel M Gore, David O'Brart, Paul French, Chris Dunsby, Bruce D Allan
PURPOSE: To measure depth-specific riboflavin concentrations in corneal stroma using two-photon fluorescence microscopy and compare commercially available transepithelial corneal collagen cross-linking (CXL) protocols. METHODS: Transepithelial CXL riboflavin preparations--MedioCross TE, Ribocross TE, Paracel plus VibeX Xtra, and iontophoresis with Ricrolin+--were applied to the corneal surface of fresh postmortem rabbit eyes in accordance with manufacturers' recommendations for clinical use...
July 2015: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/26210054/idiopathic-stromal-keratitis-resembling-central-toxic-keratopathy
#16
Vijay Kumar Wagh, Laura de Benito-Llopis, David P S O'Brart
UNLABELLED: A 28-year-old previously emmetropic woman presented with a 2-day history of bilateral photophobia and blurred vision. She had no history of corneal surgery or contact lens use. Snellen uncorrected distance visual acuity (UDVA) was 6/12 bilaterally. Bilateral anterior stromal infiltration of the central cornea was seen, with no overlying epithelial defect and intact sensation. There was a marked hyperopic shift, central corneal thinning, and associated keratometric flattening...
July 2015: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/26088738/isolated-dislocation-of-a-supplementary-sulcus-pseudophakic-intraocular-lens
#17
David P S O'Brart, Nashila Hirji
UNLABELLED: We report the case of a woman with pseudoexfoliation who presented with a hyperopic refractive surprise and uncontrolled intraocular pressure (IOP) following cataract surgery and in-the-bag intraocular lens (IOL) implantation in the left eye. Trabeculectomy was performed, and a supplementary (piggyback) sulcus IOL was inserted. At 5 years, the uncorrected distance visual acuity (UDVA) was 20/16 and the IOP was less than 21 mm Hg. Following head trauma, the patient experienced blurred vision...
June 2015: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/25467133/eighteen-year-follow-up-of-excimer-laser-photorefractive-keratectomy
#18
Zaid Shalchi, David P S O'Brart, Robert J McDonald, Parul Patel, Timothy J Archer, John Marshall
PURPOSE: To evaluate the long-term efficacy of photorefractive keratectomy (PRK). SETTING: University Hospital, London, United Kingdom. DESIGN: Prospective case series. METHODS: One eye of patients who had PRK 18 years previously was examined. All had myopic corrections with a 6.0 mm optical zone. RESULTS: Forty-six patients were examined. The mean preoperative spherical equivalent (SE) refractive error was -4...
January 2015: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/25425305/high-heritability-of-posterior-corneal-tomography-as-measured-by-scheimpflug-imaging-in-a-twin-study
#19
Omar A Mahroo, Mohammed Oomerjee, Katie M Williams, David P S O'Brart, Christopher J Hammond
PURPOSE: Anterior corneal curvature shows significant heritability. Scheimpflug imaging also permits assessment of posterior tomography. We estimated heritability of posterior and anterior tomographic parameters. METHODS: Oculus Pentacam images were obtained in twins from the TwinsUK cohort. Mean anterior and posterior radii of curvature (right cornea) were compared within twin pairs, and heritability calculated (maximum likelihood structural equation modeling, using OpenMx package)...
November 25, 2014: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/25000866/corneal-collagen-cross-linking-a-review
#20
REVIEW
David P S O'Brart
The aim was to review the published literature on corneal collagen cross-linking. The emphasis was on the seminal publications, systemic reviews, meta-analyses and randomized controlled trials. Where such an evidence did not exist, selective large series cohort studies, case controlled studies and case series with follow-up preferably greater than 12 months were included. Riboflavin/Ultraviolet A (UVA) corneal collagen cross-linking appears to be the first treatment modality to halt the progression of keratoconus and other corneal ectatic disorders with improvement in visual, keratometric and topographic parameters documented by most investigators...
July 2014: Journal of Optometry
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