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SLE Nephritis

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https://www.readbyqxmd.com/read/29325582/urinary-angiostatin-cxcl4-and-vcam-1-as-biomarkers-of-lupus-nephritis
#1
Chi Chiu Mok, Samar Soliman, Ling Yin Ho, Fatma A Mohamed, Faten Ismail Mohamed, Chandra Mohan
BACKGROUND: The aim was to study urinary angiostatin, CXC chemokine ligand 4 (CXCL4) and vascular cell adhesion molecule-1 (VCAM-1) as biomarkers of renal disease in systemic lupus erythematosus (SLE). METHOD: Patients who fulfilled ≥ 4 American College of Rheumatology (ACR) criteria for SLE with active renal, active non-renal or inactive disease, and a group of healthy controls were studied. Urine samples were assayed for angiostatin, CXCL4 and VCAM-1 by ELISA, and normalized by creatinine...
January 11, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29324237/dna-induction-of-mdm2-promotes-proliferation-of-human-renal-mesangial-cells-and-alters-peripheral-b-cells-subsets-in-pediatric-systemic-lupus-erythematosus
#2
Chen-Xing Zhang, Ji Chen, Li Cai, Jing Wu, Jia-Yuan Wang, Lan-Fang Cao, Wei Zhou, Tong-Xin Chen
The study is aimed to investigate the role of MDM2 in the pathogenesis of lupus nephritis (LN) in pediatric SLE (pSLE). We confirmed that MDM2 expression was increased in peripheral blood mononuclear cells (PBMCs) as well as renal specimen of SLE compared with that of controls by western blot and immunofluorescence staining. Percentage of apoptotic and necrotic CD4+T, CD8+T and B cells were detected by flow cytometry respectively and levels of plasma cell free DNA (cfDNA) were quantified in SLE and healthy controls (HC)...
January 8, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29321925/lupus-pneumonitis-presenting-with-high-titre-of-anti-ro-antibody
#3
Mei-Chuan Chen, Yueh-Lin Wu, Kai-Ling Lee, Kevin S Lai, Chi-Li Chung
Lupus pneumonitis carries high mortality and is a rare manifestation of systemic lupus erythematosus (SLE). However, it is difficult to diagnose and is often mistaken as pneumonia, alveolar haemorrhage, or organizing pneumonia. Previous studies demonstrated that serum anti-Ro antibodies are elevated more frequently in SLE patients with pneumonitis than in those without. We report a 21-year-old female who was newly diagnosed as having SLE with nephritis and who suddenly developed right lung opacity and rapidly progressed to severe hypoxaemia despite the use of broad-spectrum antibiotics...
January 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29320847/new-insights-into-the-role-of-renal-resident-cells-in-the-pathogenesis-of-lupus-nephritis
#4
Seung-Ki Kwok, George C Tsokos
Systemic lupus erythematosus (SLE), an autoimmune disease of unknown etiology, is characterized by the production of autoantibodies and end-organ damage. Lupus nephritis affects up to 70% of patients with SLE and is the most critical predictor of morbidity and mortality. The immunopathogenesis of SLE is complex and most clinical trials of biologics targeting immune cells or their mediators have failed to show efficacy in SLE patients. It has therefore become increasingly clear that additional, local factors give rise to the inflammation and organ damage...
January 12, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29310419/proliferative-lupus-nephritis-in-the-absence-of-overt-systemic-lupus-erythematosus-a-historical-study-of-12-adult-patients
#5
Maxime Touzot, Cécile Saint-Pastou Terrier, Stanislas Faguer, Ingrid Masson, Hélène François, Lionel Couzi, Aurélie Hummel, Nathalie Quellard, Guy Touchard, Noémie Jourde-Chiche, Jean-Michel Goujon, Eric Daugas
Severe lupus nephritis in the absence of systemic lupus erythematosus (SLE) is a rare condition with an unclear clinical presentation and outcome.We conducted a historical observational study of 12 adult (age >18 years) patients with biopsy-proven severe lupus nephritis or lupus-like nephritis without SLE immunological markers at diagnosis or during follow-up. Excluded were patients with chronic infections with HIV or hepatitis B or C; patients with a bacterial infectious disease; and patients with pure membranous nephropathy...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29301473/blood-pressure-control-over-time-in-childhood-onset-systemic-lupus-erythematous
#6
P O Avar Aydin, J Shan, H I Brunner, M M Mitsnefes
Introduction Hypertension (HTN) is prevalent in patients with systemic lupus erythematosus (SLE) and causes early cardiovascular aging and progression of renal and cardiac disease. The aim of this longitudinal retrospective study was to evaluate the prevalence of HTN, the follow-up blood pressure trends, and risk factors for HTN in a population-based cohort with childhood-onset SLE (cSLE). Methods Demographic and clinical data of consecutive visits from the baseline to the last visit were extracted from electronic medical records of patients with cSLE...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29287313/multi-center-delphi-exercise-reveals-important-key-items-for-classifying-systemic-lupus-erythematosus
#7
Gabriela Schmajuk, Bimba F Hoyer, Martin Aringer, Sindhu R Johnson, David I Daikh, Thomas Dörner
BACKGROUND: The European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR) embarked on a project to re-evaluate classification criteria for systemic lupus erythematosus (SLE). The first phase of the classification project involved generation of a broad set of items potentially useful for classification of SLE and their selection for use in a subsequent forced-choice decision analysis. METHODS: A large international group of expert lupus clinicians was invited to participate in a 2-step process to generate, rate and select items based on their importance in diagnosing early and established SLE, respectively, via a web-based survey...
December 29, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29274388/il-21-dependent-granzyme-b-production-of-b-cells-is-decreased-in-patients-with-lupus-nephritis
#8
Mariam Rabani, Benjamin Wilde, Katharina Hübbers, Shilei Xu, Andreas Kribben, Oliver Witzke, Sebastian Dolff
OBJECTIVES: B-cells play a crucial role in the pathogenesis of lupus nephritis. Recently, a separate subset has been discovered characterized by expression of Granzyme B. The aim of this study is to investigate this subset in patients with systemic lupus erythematosus (SLE). METHODS: Isolated PBMCs of SLE-patients (n=30) and healthy controls (n=21) were in vitro stimulated with CPG, IgG+IgM and IL-21. Patients were sub-grouped in patients with and without biopsy proven lupus nephritis...
December 20, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29259835/efficacy-of-rituximab-in-a-systemic-lupus-erythematosus-patient-presenting-with-diffuse-alveolar-hemorrhage
#9
Gabriela Montes-Rivera, Grissel Ríos, Luis M Vilá
Diffuse alveolar hemorrhage (DAH) is a life-threatening complication of systemic lupus erythematosus (SLE). Although infrequent, its mortality is very high. While there are no established therapeutic guidelines, DAH has been traditionally managed with high-dose intravenous (IV) corticosteroids, cyclophosphamide, and plasma exchange. The efficacy of alternative therapies such as rituximab has been described only in a few cases. Herein, we report a 25-year-old Hispanic man who presented with acute-onset SLE manifested by polyarthralgia, nephritis, seizures, pancytopenia, severe hypocomplementemia, and elevated anti-dsDNA antibodies...
2017: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/29241417/neuropsychiatric-manifestations-are-not-uncommon-in-indian-lupus-patients-and-negatively-affect-quality-of-life
#10
H Muhammed, M Goyal, V Lal, S Singh, V Dhir
Objectives The objectives of this paper are to look at the prevalence of neuropsychiatric manifestations and assess their impact on quality of life in North Indian lupus patients. Methods The study included consecutive patients with systemic lupus erythematosus (SLE) who were older than 18 years and met the SLICC 2012 criteria. A diagnosis of a neuropsychiatric syndrome was made as per ACR 1999 definitions. Manifestations occurring at any point in time after the diagnosis of SLE were considered if a reliable history and medical records were available...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/29237779/estrogen-receptor-%C3%AE-signaling-exacerbates-immune-mediated-nephropathies-through-alteration-of-metabolic-activity
#11
Chelsea Corradetti, Neelakshi R Jog, Matteo Cesaroni, Michael Madaio, Roberto Caricchio
Glomerulonephritis is one of the most serious manifestations of systemic lupus erythematous (SLE). Because SLE is ≥10 times more common in women, a role for estrogens in disease pathogenesis has long been suspected. Estrogen receptor α (ERα) is highly expressed in renal tissue. We asked whether ERα expression contributes to the development of immune-mediated nephropathies like in lupus nephritis. We tested the overall effects of estrogen receptors on the immune response by immunization with OVA and induction of chronic graft-versus-host disease in female ERα-knockout mice...
December 13, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29225917/role-of-p-glycoprotein-on-cd69-cd4-cells-in-the-pathogenesis-of-proliferative-lupus-nephritis-and-non-responsiveness-to-immunosuppressive-therapy
#12
Shizuyo Tsujimura, Tomoko Adachi, Kazuyoshi Saito, Yoshiya Tanaka
Introduction: P-glycoprotein (P-gp) expression on activated lymphocytes in systemic lupus erythematosus (SLE) plays a role in active efflux of intracellular drugs, resulting in drug resistance. The role of P-gp-expressing lymphocytes in the pathogenesis of SLE remains unclear. The aim of this study was to determine the importance of P-gp+CD4+ cells in organ manifestations in refractory SLE. Methods: The proportion of P-gp+CD4+ cells was determined by flow cytometry in peripheral blood of patients with SLE (n=116) and healthy adults (n=10)...
2017: RMD Open
https://www.readbyqxmd.com/read/29224682/calcineurin-inhibitors-in-systemic-lupus-erythematosus
#13
REVIEW
Chi Chiu Mok
The calcineurin inhibitors (CNIs) belong to a group of immunosuppressive agents that block T-cell activation through the suppression of the calcium/calcimodulin-dependent phosphatase calcineurin. Agents such as cyclosporine A (CSA) and tacrolimus (TAC) have long been used in patients with systemic lupus erythematosus (SLE). TAC is preferred to CSA in SLE because of the lower frequency of cosmetic, hypertensive and dyslipidemic adverse effects. Recent randomised controlled trials have demonstrated noninferiority of TAC to mycophenolate mofetil (MMF) or cyclophosphamide (CYC) for induction therapy of lupus nephritis...
June 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29224680/pregnancy-in-systemic-lupus-erythematosus-and-antiphospholipid-syndrome
#14
REVIEW
Rebecca Fischer-Betz, Christof Specker
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease with a high prevalence in females of childbearing age. Pregnancy in SLE nowadays has favorable outcomes for the majority of women. However, flares of disease activity, preeclampsia, fetal loss, and preterm birth are well-known risks in such pregnancies. Anti-SS-A(Ro)/SS-B(La) antibodies put fetuses at risk for congenital heart block and neonatal lupus. Several risk factors for adverse pregnancy outcomes have been identified. Women with antiphospholipid antibodies or antiphospholipid syndrome and lupus nephritis represent a group with high risk for obstetric complications...
June 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29208022/role-of-endoplasmic-reticulum-stress-in-the-protective-effects-of-ppar%C3%AE-%C3%AE-activation-on-endothelial-dysfunction-induced-by-plasma-from-patients%C3%A2-with-lupus
#15
Marta Toral, Rosario Jiménez, Miguel Romero, Iñaki Robles-Vera, Manuel Sánchez, Mercedes Salaices, José Mario Sabio, Juan Duarte
BACKGROUND: We tested whether GW0742, a peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) agonist, improves endothelial dysfunction induced by plasma from patients with systemic lupus erythematosus (SLE) involving the inhibition of endoplasmic reticulum (ER) stress. METHODS: A total of 12 non-pregnant women with lupus and 5 non-pregnant healthy women (controls) participated in the study. Cytokines and double-stranded DNA autoantibodies (anti-dsDNA) were tested in plasma samples...
December 6, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29208014/plasma-c4d-as-marker-for-lupus-nephritis-in-systemic-lupus-erythematosus
#16
Myriam Martin, Karolina I Smoląg, Albin Björk, Birgitta Gullstrand, Marcin Okrój, Jonatan Leffler, Andreas Jönsen, Anders A Bengtsson, Anna M Blom
BACKGROUND: In the present study, we sought to evaluate the complement activation product C4d as a marker for lupus nephritis in systemic lupus erythematosus (SLE). METHODS: C4d levels were determined by enzyme-linked immunosorbent assay in plasma samples of patients with established SLE using a novel approach based on detection of a short linear cleavage neoepitope. Cross-sectional associations were studied in 98 patients with SLE with samples taken at lower or higher respective disease activity...
December 6, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29207897/association-of-the-cd11b-rs1143679-polymorphism-with-systemic-lupus-erythematosus-in-the-han-chinese-population
#17
Chunmei Li, Fengqing Tong, Yi Ma, Kai Qian, Junyu Zhang, Xingguo Chen
Objective To investigate the association of the CD11b single nucleotide polymorphism (SNP) rs1143679 with systemic lupus erythematosus (SLE) in Han Chinese patients, and to clarify this association with SLE clinical manifestations. Methods PCR-restriction fragment length polymorphism and direct sequencing of CD11b rs1143679 were conducted in 584 patients with SLE and 628 healthy controls in this case-control study to compare genotype and allele frequency distributions. Correlations between CD11b genotypes and clinical manifestations were also determined...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29205894/association-of-angiotensin-converting-enzyme-insertion-deletion-polymorphism-with-susceptibility-to-systemic-lupus-erythematosus-a-meta-analysis
#18
An-Fang Huang, Hui Li, Lei Ke, Chao Yang, Xiao-Yan Liu, Zu-Cheng Yang, Fen Xu, Hong Jia, Wang-Dong Xu
BACKGROUND: The aim of this study was to determine whether the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism confers susceptibility to systemic lupus erythematosus (SLE)/lupus nephritis (LN). METHODS: A meta-analysis was conducted on the association between the ACE I/D polymorphism and SLE/LN (when available) using: (i) the allelic contrast; (ii) the recessive; (iii) the dominant; and (iv) the additive models. RESULTS: A total of 27 relevant comparisons meeting the inclusion criteria were identified, involving 2718 SLE patients and 3655 controls...
December 5, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29193893/sex-differences-in-healthcare-utilization-end-stage-renal-disease-and-mortality-among-medicaid-beneficiaries-with-incident-lupus-nephritis
#19
Candace H Feldman, Anna Broder, Hongshu Guan, Jinoos Yazdany, Karen H Costenbader
OBJECTIVE: While systemic lupus erythematosus (SLE) and lupus nephritis (LN) disproportionately affect females, prior studies suggest that males may experience poorer outcomes. We investigated sex differences in healthcare utilization, end-stage renal disease (ESRD) and mortality among patients with LN receiving Medicaid, public insurance for low-income individuals. METHODS: Within Medicaid Analytic eXtract (MAX) from 29 states (2000-2010), we used billing claims to identify individuals 5-65 years with incident LN (PPV 80%)...
November 28, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29192160/a-novel-human-systemic-lupus-erythematosus-model-in-humanised-mice
#20
Merry Gunawan, Zhisheng Her, Min Liu, Sue Yee Tan, Xue Ying Chan, Wilson Wei Sheng Tan, Shubasree Dharmaraaja, Yong Fan, Chee Bing Ong, Eva Loh, Kenneth Tou En Chang, Thiam Chye Tan, Jerry Kok Yen Chan, Qingfeng Chen
Mouse models have contributed to the bulk of knowledge on Systemic Lupus Erythematosus (SLE). Nevertheless, substantial differences exist between human and mouse immune system. We aimed to establish and characterise a SLE model mediated by human immune system. Injection of pristane into immunodeficient mice reconstituted with human immune system (humanised mice) recapitulated key SLE features, including: production of human anti-nuclear autoantibodies, lupus nephritis, and pulmonary serositis. There was a reduction in the number of human lymphocytes in peripheral blood, resembling lymphopenia in SLE patients...
November 30, 2017: Scientific Reports
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