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https://www.readbyqxmd.com/read/27888495/an-unusual-presentation-of-intraocular-tuberculosis-in-a-monocular-patient-clinicopathological-correlation
#1
Kanika Aggarwal, Aniruddha Agarwal, Shobha Sehgal, Suryaprakash Sharma, Nirbhai Singh, Kusum Sharma, Ramanuj Samanta, Alessandro Invernizzi, Aman Sharma, Vishali Gupta
BACKGROUND: Lack of uniform diagnostic criteria often poses a challenge in the diagnosis and management of tubercular uveitis. The index case describes an unusual presentation of tubercular panuveitis initially misdiagnosed as sympathetic ophthalmia, where the appropriate diagnosis was made using various imaging and laboratory investigations. RESULTS: A 52-year-old Indian woman underwent multimodal imaging, extensive clinical and laboratory work-up, and analysis of microbiological and histopathological specimens...
December 2016: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/27863187/cytology-of-primary-vaginal-melanoma-an-unusual-report-on-fine-needle-aspiration
#2
Poojan Agarwal, Manju Kaushal
Primary malignant melanoma of the vagina is an extremely uncommon malignancy comprising of less than 10% malignancies of the female genital tract and 0.3% of all melanomas. Melanoblasts are neural crest derivatives and are notorious for causing primary cutaneous neoplasms. However, they involve virtually every organ of the body including eye, intestines and ocular mucosa, probably due to aberrancies in cell migration. Vagina is a rare site and primary melanoma of the vagina occurs in postmenopausal women with vaginal discharge, bleeding, or mass as common presenting complaints...
November 11, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27849402/a-review-of-the-role-of-intravitreal-corticosteroids-as-an-adjuvant-to-antibiotics-in-infectious-endophthalmitis
#3
Dawn Ching Wen Ho, Aniruddha Agarwal, Cecilia S Lee, Jay Chhablani, Vishali Gupta, Manoj Khatri, Jayabalan Nirmal, Carlos Pavesio, Rupesh Agrawal
Infectious endophthalmitis is an important cause of vision loss worldwide. This entity most often occurs as a complication of intraocular surgery especially following cataract surgery or intravitreal injection. Endophthalmitis is regarded as a serious complication following ocular surgery and the final visual outcome is fundamentally contingent on timely recognition and intervention. Intravitreal and oral antibiotics in combination with pars plana vitrectomy or vitreous aspiration remain the mainstay in the management of endophthalmitis...
November 16, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27726520/multimodal-imaging-in-ocular-tuberculosis
#4
Aniruddha Agarwal, Sarakshi Mahajan, Moncef Khairallah, Padmamalini Mahendradas, Amod Gupta, Vishali Gupta
Intraocular tuberculosis presents a diagnostic challenge because of its protean clinical manifestations. Thus, it becomes imperative to distinguish chorioretinal inflammation due to tuberculosis from other infectious as well as non-infectious posterior uveitis since the clinical manifestations of these entities may be quite similar. With advancing technology, a number of novel imaging modalities are available today that enable in vivo near-histologic assessment of the chorioretinal tissue, greatly aiding the clinician in establishing a diagnosis and monitoring the therapeutic response of tubercular lesions...
October 11, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27595117/correlation-between-tear-fluid-and-serum-vitamin-d-levels
#5
Swaminathan Sethu, Rohit Shetty, Kalyani Deshpande, Natasha Pahuja, Nandini Chinnappaiah, Aarti Agarwal, Anupam Sharma, Arkasubhra Ghosh
BACKGROUND: Vitamin D deficiency is associated with a range of systemic diseases including ocular disorders. The objective of this study is to measure tear vitamin D levels and investigate the correlation between serum and tear vitamin D levels. METHODS: A total of 48 healthy volunteers without any systemic and ocular disease were recruited for this observational cohort study. Serum was collected using clot activator coated Vacutainer® Plus tubes. Tear fluid was collected using Schirmer's strips...
2016: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/27494951/assessment-of-retinal-vascular-calibres-as-a-biomarker-of-disease-activity-in-birdshot-chorioretinopathy
#6
Rupesh Agrawal, Nichole Joachim, Ling-Jun Li, Jiaying Lee, Aniruddha Agarwal, Dawn A Sim, Pearse A Keane, Gerald Liew, Carlos E Pavesio
PURPOSE: Birdshot chorioretinopathy (BCR) is a potentially blinding ocular disorder involving the retinal vasculature and choroid without any systemic manifestations. The objective of the study was to describe vascular calibre changes in BCR and analyse the possibility of this optical biomarker for staging and monitoring disease activity in BCR. METHODS: This retrospective case-control study at a tertiary referral eye centre in the UK included 33 eyes from 21 patients with BCR and equal number of eyes from control subjects...
August 6, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27327041/corneal-toxicity-induced-by-vesicating-agents-and-effective-treatment-options
#7
Dinesh G Goswami, Neera Tewari-Singh, Rajesh Agarwal
The vesicating agents sulfur mustard (SM) and lewisite (LEW) are potent chemical warfare agents that primarily cause damage to the ocular, skin, and respiratory systems. However, ocular tissue is the most sensitive organ, and vesicant exposure results in a biphasic injury response, including photophobia, corneal lesions, corneal edema, ulceration, and neovascularization, and may cause loss of vision. There are several reports on ocular injury from exposure to SM, which has been frequently used in warfare. However, there are very few reports on ocular injury by LEW, which indicate that injury symptoms appear instantly after exposure and faster than SM...
June 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27176114/optical-coherence-tomography-angiography-a-non-invasive-tool-to-image-end-arterial-system
#8
Rupesh Agrawal, Wei Xin, Pearse A Keane, Jay Chhablani, Aniruddha Agarwal
No abstract text is available yet for this article.
June 2016: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/27127902/retinal-neovascularisation-in-susac-syndrome-a-rare-complication
#9
Kshitiz Kumar, Bhavini Jariwala, Pallavi Raj, Amar Agarwal
PURPOSE: To report a case of Susac syndrome with ocular complications in the chronic stage of the disease. METHODS: Case report. RESULTS: A 37-year-old male patient of Indian origin presented with painless blurring of vision in the right eye. Ophthalmoscopic examination revealed vitreous hemorrhage in the right eye and NVE in both eyes well-documented angiographically. Old medical records revealed a previous attack of bilateral BRAO as a complete triad of Susac syndrome 10 years before, with an uncomplicated clinical course...
April 29, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/27124779/conjunctival-microbial-flora-in-ocular-stevens-johnson-syndrome-sequelae-patients-at-a-tertiary-eye-care-center
#10
Renu Venugopal, Gita Satpathy, Sushil Sangwan, Arti Kapil, Neelima Aron, Tushar Agarwal, Neelam Pushker, Namrata Sharma
PURPOSE: To evaluate the conjunctival microbial flora in cases of ocular Stevens-Johnson Syndrome (SJS) in a tertiary eye care center. METHODS: This prospective study comprised 176 eyes of 88 patients with ocular SJS compared with 124 eyes of normal subjects. The conjunctival swabs were collected and sent for microbiological analysis for bacterial isolation and antibiotic sensitivity examination. The type of bacteria isolated and its antibiotic sensitivity pattern were studied...
August 2016: Cornea
https://www.readbyqxmd.com/read/27093100/cross-linking-for-microbial-keratitis
#11
Tommy C Y Chan, Tushar Agarwal, Rasik B Vajpayee, Vishal Jhanji
PURPOSE OF REVIEW: Microbial keratitis is one of the leading causes of ocular morbidity. The standard treatment consists of antibiotics, which is intensive and is fraught with risks of antibiotic resistance. Corneal collagen cross-linking (CXL) has recently been advocated as an adjunctive therapy for management of microbial keratitis. The addition of CXL to ongoing antimicrobial treatment can have a potential effect on overall duration of the disease, need for corneal transplantation, final visual outcome, and long-term impact on drug resistance pattern...
July 2016: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/27080149/modern-approaches-to-the-ocular-delivery-of-cyclosporine-a
#12
REVIEW
Priyanka Agarwal, Ilva D Rupenthal
Cyclosporine A (CsA) has long been the mainstay treatment for dry eye syndrome (DES), one of the most common disorders of the eye. However, the poor water solubility of CsA renders it difficult to formulate it into topical ocular dosage forms. Restasis® is currently the only US Food and Drug Administration (FDA)-approved CsA formulation, while Ikervis® has recently been launched in Europe, with both commonly associated with severe ocular discomfort. Therefore, several CsA formulations have been investigated with the aim to improve bioavailability while reducing adverse effects associated with the marketed formulations...
June 2016: Drug Discovery Today
https://www.readbyqxmd.com/read/27057752/high-resolution-imaging-of-parafoveal-cones-in-different-stages-of-diabetic-retinopathy-using-adaptive-optics-fundus-camera
#13
Mohamed Kamel Soliman, Mohammad Ali Sadiq, Aniruddha Agarwal, Salman Sarwar, Muhammad Hassan, Mostafa Hanout, Frank Graf, Robin High, Diana V Do, Quan Dong Nguyen, Yasir J Sepah
PURPOSE: To assess cone density as a marker of early signs of retinopathy in patients with type II diabetes mellitus. METHODS: An adaptive optics (AO) retinal camera (rtx1™; Imagine Eyes, Orsay, France) was used to acquire images of parafoveal cones from patients with type II diabetes mellitus with or without retinopathy and from healthy controls with no known systemic or ocular disease. Cone mosaic was captured at 0° and 2°eccentricities along the horizontal and vertical meridians...
2016: PloS One
https://www.readbyqxmd.com/read/27002633/clinical-progression-of-ocular-injury-following-arsenical-vesicant-lewisite-exposure
#14
Neera Tewari-Singh, Claire R Croutch, Richard Tuttle, Dinesh G Goswami, Rama Kant, Eric Peters, Tara Culley, David A Ammar, Robert W Enzenauer, J Mark Petrash, Robert P Casillas, Rajesh Agarwal
Ocular injury by lewisite (LEW), a potential chemical warfare and terrorist agent, results in edema of eyelids, inflammation, massive corneal necrosis and blindness. To enable screening of effective therapeutics to treat ocular injury from LEW, useful clinically-relevant endpoints are essential. Hence, we designed an efficient exposure system capable of exposing up to six New-Zealand white rabbits at one time, and assessed LEW vapor-induced progression of clinical ocular lesions mainly in the cornea. The right eye of each rabbit was exposed to LEW (0...
December 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/26922651/vanishing-retinal-arterial-aneurysms-with-anti-tubercular-treatment-in-a-patient-presenting-with-idiopathic-retinal-vasculitis-aneurysms-and-neuroretinitis
#15
Ramandeep Singh, Kusum Sharma, Aniruddha Agarwal, Mohit Dogra, Vishali Gupta, Aman Sharma, Mangat R Dogra
BACKGROUND: Idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome presents with characteristic clinical manifestations such as aneurysms at arteriolar bifurcations and optic nerve and retinal vascular inflammation. Regression of such features on treatment with anti-tubercular therapy (ATT) combined with corticosteroids has not been reported in literature. FINDINGS: A 30-year-old female with sudden painless decreased vision in the left eye was referred with a diagnosis of presumed tuberculous retinal vasculitis and a positive tuberculin skin test...
December 2016: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/26910292/ocular-manifestations-in-patients-with-human-immunodeficiency-virus-infection-in-the-pre-haart-versus-the-haart-era-in-the-north-indian-population
#16
Aniruddha Agarwal, Ramandeep Singh, Aman Sharma, Vishali Gupta, Mangat R Dogra
PURPOSE: To compare changes in the demographic profile and ocular manifestations in patients with HIV in the pre-HAART and HAART era in North India. METHODS: In this single-center cross-sectional study, 100 HIV patients receiving HAART and 96 HIV patients in the pre-HAART era were enrolled. Prevalence of ocular manifestations of HIV was calculated for both cohorts. RESULTS: The prevalence of ocular manifestations was not statistically different in the two eras (38%, SE: 4...
February 24, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/26903733/scleral-necrosis-in-congenital-erythropoietic-porphyria-a-case-report-and-review-of-the-literature
#17
Shweta Agarwal, Parthopratim Dutta Majumder, Bhaskar Srinivasan, Geetha Iyer
A 28-year-old presented with complaints of severe pain and redness in the left eye since 2 weeks. He had similar complaints in the right eye 2 years back for which he had undergone a scleral patch graft. Best corrected visual acuity was 20/20 in both eyes. The right had a well vascularized scleral graft and rest of the anterior segment was normal. The left eye had inferior conjunctival congestion with an area of the scleral melt with uveal show just temporal to the limbus in the interpalbebral area. The cornea was clear and anterior chamber was quiet in the left eye...
September 2015: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/26857947/aflibercept-for-neovascular-age-related-macular-degeneration
#18
REVIEW
Salman Sarwar, Elizabeth Clearfield, Mohamed Kamel Soliman, Mohammad Ali Sadiq, Andrew J Baldwin, Mostafa Hanout, Aniruddha Agarwal, Yasir J Sepah, Diana V Do, Quan Dong Nguyen
BACKGROUND: Central vision loss caused by age-related macular degeneration (AMD) is the leading cause of blindness among the elderly in developed countries. Neovascular AMD is characterized by choroidal neovascularization (CNV). Growth of new blood vessels in patients with neovascular AMD is driven by a complex process that involves a signal protein called vascular endothelial growth factor A (VEGF-A). Anti-VEGF drugs that block this protein include ranibizumab, bevacizumab, and aflibercept...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26851243/comparing-smartphone-camera-adapters-in-imaging-post-operative-cataract-patients
#19
Thuss Sanguansak, Katharine Morley, Michael Morley, Suwat Kusakul, Ramon Lee, Eric Shieh, Yosanan Yospaiboon, Chavakij Bhoomibunchoo, Siriwatana Chai-Ear, Anthony Joseph, Isha Agarwal
INTRODUCTION: The goal of this study is to compare image quality and clinical confidence for managing post-operative cataract patients based on anterior segment smartphone images obtained in real-world settings using four types of adapters: (a) macro lens (ML), (b) ML with augmented light-emitting diode (LED) illumination (ML-LED), (c) no adapter (NA) and (d) slit lamp (SL) adapter. METHODS: Anterior segment images were obtained from 190 eyes after cataract surgery using an eight-megapixel iPhone 6 smartphone camera with four adapters: ML, ML-LED, NA, and SL...
February 4, 2016: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/26762419/in-vitro-and-ex-vivo-corneal-penetration-and-absorption-models
#20
Priyanka Agarwal, Ilva D Rupenthal
Topical drug administration is the preferred route of drug delivery to the eye despite the poor bioavailability. To develop more efficient drug carriers, reliable in vitro or ex vivo models are required in the early stages of formulation development, with such methods being faster, cheaper, and more ethical alternatives to in vivo studies. In vitro cell culture models are increasingly being used for transcorneal penetration studies, with primary cell cultures and immortalized cell lines now giving way to the development of organotypic corneal constructs for studying ocular drug bioavailability...
January 13, 2016: Drug Delivery and Translational Research
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