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https://www.readbyqxmd.com/read/28887113/primary-month-6-outcomes-of-the-stop-uveitis-study-evaluating-the-safety-tolerability-and-efficacy-of-tocilizumab-in-patients-with-non-infectious-uveitis
#1
Yasir Jamal Sepah, Mohammad Ali Sadiq, David S Chu, Mark Dacey, Ron Gallemore, Pouya Dayani, Mostafa Hanout, Muhammad Hassan, Rubbia Afridi, Aniruddha Agarwal, Muhammad Sohail Halim, Diana V Do, Quan Dong Nguyen
PURPOSE: To report the primary end-point analyses of the safety and efficacy of two different doses of intravenous (IV) infusions of tocilizumab (TCZ), an IL-6 inhibitor, in eyes with non-infectious intermediate, posterior or pan-uveitis. DESIGN: Randomized, controlled, multicenter clinical trial. METHODS: STOP-Uveitis is a randomized, open-label safety, efficacy and bioactivity clinical trial conducted at 5 clinical centers across the United States...
September 5, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28781889/evaluation-of-macular-and-peripapillary-vessel-flow-density-in-eyes-with-no-known-pathology-using-optical-coherence-tomography-angiography
#2
Muhammad Hassan, Mohammad Ali Sadiq, Muhammad Sohail Halim, Rubbia Afridi, Mohamed K Soliman, Salman Sarwar, Aniruddha Agarwal, Diana V Do, Quan Dong Nguyen, Yasir Jamal Sepah
PURPOSE: To assess normal vessel flow density (VFD) in macular and peripapillary regions of eyes with no known ocular pathology using optical coherence tomography angiography (OCTA). METHODS: AngioVue (Optovue, Fremont, CA, USA) was used to capture OCTA images. A 3 × 3 mm grid and a 4.5 × 4.5 mm grid was used to scan parafoveal and peripapillary regions, respectively. ReVue software was utilized to measure VFD in five sectors within the inner two circles of ETDRS grid in macular region and correlated to retinal thickness of same sectors...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28757693/effect-of-phacoemulsification-on-measurement-of-retinal-nerve-fiber-layer-and-optic-nerve-head-parameters-using-spectral-domain-optical-coherence-tomography
#3
Bhaskar Jha, Reetika Sharma, Murugesan Vanathi, Tushar Agarwal, Talvir Sidhu, Ankit Tomar, Tanuj Dada
PURPOSE: The purpose of this study is to determine the effect of phacoemulsification cataract extraction on measurement of retinal nerve fiber layer and optic nerve head parameters using spectral domain optical coherence tomography. MATERIAL AND METHODS: A prospective, hospital-based study of 100 patients of 40 years of age and above, with no other ocular morbidity except cataract and planned for phacoemulsification with IOL implantation (SN60WF) at a tertiary centre at AIIMS, New Delhi, India...
May 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/28730085/ocular-surface-evaluation-in-eyes-with-chronic-glaucoma-on-long-term-topical-antiglaucoma-therapy
#4
Manu Saini, Murugesan Vanathi, Tanuj Dada, Tushar Agarwal, Rebika Dhiman, Sudarshan Khokhar
AIM: To evaluate ocular surface changes and its correlation with the central corneal subbasal nerve fibre layer in chronic glaucoma patients. METHODS: A prospective comparative study of ocular surface evaluation was performed in 50 eyes of 25 patients using two or more antiglaucoma medications for at least 6mo and 50 eyes of 25 normal subjects without any ocular problems as controls. The study parameters evaluated included visual acuity, intraocular pressure, ocular surface evaluation parameters [fluorescein break-up time (FTBUT), Schirmer's I test, ocular surface staining scores and ocular surface disease index score (OSDI)], central corneal sensation (Cochet Bonnett aesthesiometer), central subbasal nerve fiber layer density (SBNFLD) by confocal microscopy...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28696172/multimodal-imaging-in-retinal-vasculitis
#5
Aniruddha Agarwal, Rubbia Afridi, Rupesh Agrawal, Diana V Do, Vishali Gupta, Quan Dong Nguyen
Retinal vasculitis presents with inflammation involving the retinal vasculature as an isolated disease or in combination with other ocular or systemic conditions. This entity may be associated with a wide variety of clinical manifestations such as vascular sheathing, cotton-wool spots, retinal ischemia, and neovascularization. Often, retinal vasculitis and its complications lead to diagnostic challenges in identifying the exact etiology of the inflammation. Ancillary investigations such as fundus photography, fluorescein angiography, and more recently, adaptive optics imaging and optical coherence tomography angiography, may provide valuable information that help in establishing the exact diagnosis and initiation of appropriate therapy...
June 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28689166/ocular-surface-cytokine-profile-in-chronic-stevens-johnson-syndrome-and-its-response-to-mucous-membrane-grafting-for-lid-margin-keratinisation
#6
Srividya Gurumurthy, Geetha Iyer, Bhaskar Srinivasan, Shweta Agarwal, Narayanasamy Angayarkanni
BACKGROUND: To study the tear cytokine and the conjunctival and oral mucosal marker profile in chronic ocular Stevens-Johnson syndrome (SJS) and their alteration following mucous membrane grafting (MMG) for lid margin keratinisation (LMK). METHODS: In a 1-year prospective study, SJS cases (n=25) and age-matched/sex-matched healthy controls (n=25) were recruited. Tear specimen (Schirmer's strip), conjunctival and oral mucosal imprints were collected from controls and SJS cases pre-MMG and post-MMG (at first follow-up, n=17)...
July 8, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28582375/pythium-insidiosum-keratitis-histopathology-and-rapid-novel-diagnostic-staining-technique
#7
Ruchi Mittal, Shipra K Jena, Alisha Desai, Sunil Agarwal
PURPOSE: To elucidate the histopathology of Pythium insidiosum keratitis and to describe a novel, simple, and rapid staining technique for identification of oomycete Pythium insidiosum and to differentiate it from fungi. METHODS: This is a laboratory investigation study of 38 nonconsecutive cases (37 ocular samples and 1 colonic biopsy); 14 microbiologically diagnosed as Pythium insidiosum keratitis and 24 as fungal keratitis. Review of clinical, demographic details, microbiological results, and identification of cases that necessitated evisceration was performed...
June 2, 2017: Cornea
https://www.readbyqxmd.com/read/28557835/giant-ocular-surface-squamous-neoplasia-wrapping-whole-cornea
#8
Dhivya Ashok Kumar, Amar Agarwal
We present a giant ocular surface squamous neoplasia (OSSN) measuring approximately 20×18 mm arising from the fornix and wrapping the entire 12 clock hours of the cornea. The surgical excision was performed with preservation of the corneal surface. A 3-mm clear margin was obtained all around the mass. The histopathology confirmed as moderately differentiated squamous cell carcinoma with clear margins. The postoperative period was uneventful, and a clear cornea without a residual scar with best corrected visual acuity of 20/20 was attained...
May 26, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28511470/study-on-steroid-induced-ocular-findings-in-children-with-nephrotic-syndrome
#9
Vijay Agrawal, Kusum Devpura, Laxmikant Mishra, Sajan Agarwal
INTRODUCTION: Long term use of corticosteroids in Nephrotic Syndrome (NS) is associated with ocular complications such as Posterior Subcapsular Cataract (PSC), glaucoma, increased intra-ocular pressure, ptosis, mydriasis, eyelid skin atrophy, keratisis, thinning of cornea and sclera, repeated hordeolum exacerbations. AIM: To determine ocular abnormalities in children with NS and their association with steroid dosing and duration. MATERIALS AND METHODS: Hundred patients with NS in the age group of 2-18 years, with no evidence of other systemic disease, were considered for the study...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28501948/corneal-tomography-and-biomechanics-in-primary-pterygium
#10
M Vanathi, Sahil Goel, Anita Ganger, Tushar Agarwal, T Dada, Sudarshan Khokhar
PURPOSE: To study the Scheimpflug's imaging and corneal biomechanics in primary pterygium. METHODS: A prospective observational study of 55 patients with unilateral primary nasal pterygium was done. The normal fellow eyes of patients with pterygium were taken as controls. Clinical parameters noted included visual acuity, values of corneal curvature by doing Scheimpflug imaging, wavefront aberrations in terms of higher and lower-order aberrations and corneal hysteresis (CH) as well as corneal resistance factor (CRF) values by using ocular response analyzer...
May 13, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28407620/outcome-of-allo-simple-limbal-epithelial-transplantation-alloslet-in-the-early-stage-of-ocular-chemical-injury
#11
Geetha Iyer, Bhaskar Srinivasan, Shweta Agarwal, Anil Tarigopula
PURPOSE: To analyse the outcome of allo simple limbal epithelial transplantation (alloSLET) in eyes in the early stage following ocular chemical injury to achieve rapid epithelialisation. PATIENTS AND METHODS: Records of 18 eyes of 17 patients who underwent alloSLET between April 2013 and Jan 2016 were analysed retrospectively. Patients with grade 4 or worse Dua's classification for chemical injury, who presented within a month of the injury or with a non-healing epithelial defect since the injury despite earlier medical or surgical interventions, were included in the study...
June 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28345570/appraising-the-spectrum-of-firework-trauma-and-the-related-laws-during-diwali-in-north-india
#12
Ramesh Venkatesh, Prachi Gurav, Shailja Tibrewal, Manisha Agarwal, Suneeta Dubey, Umang Mathur, Suma Ganesh, Sima Das
PURPOSE: To evaluate the epidemiological characteristics and outcomes of ocular injuries resulting from the use of firecrackers during the Diwali festival in all age groups. MATERIALS AND METHODS: A single-center, retrospective, hospital-based case series presenting with ocular trauma consequent to fireworks usage in a tertiary eye care center in North India during the 5 days of Diwali festival from 2011 to 2015 was conducted. RESULTS: A total of 53 eyes of 45 patients were included in the study, out of which the vast majority (39/87%) were males...
February 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28163542/presumed-isotretinoin-induced-extraocular-myopathy
#13
Md Shahid Alam, Swati Agarwal
Isotretinoin a synthetic analogue of vitamin A is primarily used for cystic acne not responding to conventional treatment. Several ocular side effects including blurring of vision, decreased dark adaptation, corneal opacities and meibomian gland atrophy have been reported with prolonged use of isotretinoin. There have been reports of muscular damage caused by isotretinoin. Extra ocular myopathy as an adverse effect of long term used of isotretinoin has never been mentioned in literature. We report a case of a young male who presented to us with complaints of diplopia after using isotretinoin for a prolonged period...
October 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/28112131/polymerase-chain-reaction-for-mycobacterium-tuberculosis-dna-detection-from-ocular-fluids-in-patients-with-various-types-of-choroiditis-in-a-referral-eye-center-in-india
#14
Jyotirmay Biswas, Mohmmad Salman Kazi, Vishvesh Ashokkumar Agarwal, Md Shahid Alam, K Lily Therese
AIMS: The aim of this study was to detect Mycobacterium tuberculosis (MTB) DNA with polymerase chain reaction (PCR) in aqueous or vitreous samples of patients suffering from choroiditis presumed to be infectious origin. SETTINGS AND DESIGN: Hospital-based, retrospective case-control study. SUBJECTS AND METHODS: In all, forty eyes of forty patients with choroiditis divided into two groups - Group A (serpiginous-like choroiditis, ampiginous choroiditis, multifocal choroiditis) and Group B (choroidal abscess, miliary tuberculosis (TB), choroidal tubercle) were analyzed retrospectively...
December 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28012878/viral-posterior-uveitis
#15
REVIEW
Joanne H Lee, Aniruddha Agarwal, Padmamalini Mahendradas, Cecilia S Lee, Vishali Gupta, Carlos E Pavesio, Rupesh Agrawal
The causes of posterior uveitis can be divided into infectious, autoimmune, or masquerade syndromes. Viral infections, a significant cause of sight-threatening ocular diseases in the posterior segment, include human herpesviruses, measles, rubella, and arboviruses such as dengue, West Nile, and chikungunya virus. Viral posterior uveitis may occur as an isolated ocular disease in congenital or acquired infections or as part of a systemic viral illness. Many viruses remain latent in the infected host with a risk of reactivation that depends on various factors, including virulence and host immunity, age, and comorbidities...
July 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28012873/posner-schlossman-syndrome
#16
REVIEW
Roly Megaw, Pankaj Kumar Agarwal
Posner-Schlossman syndrome, or glaucomatocyclitic crisis, is a unilateral ocular condition characterized by recurrent attacks of nongranulomatous anterior uveitis and raised intraocular pressure that can result in chronic secondary glaucoma. This relatively rare disease is most likely the result of recurrent cytomegalovirus infection and affects predominantly middle-aged males. Diagnosis is largely clinical, with aqueous and blood sampling aiding the identification of any underlying infectious cause. Successful disease management is often achieved by topical treatment, although systemic therapy and even surgical intervention may be required...
May 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28005674/didanosine-retinal-toxicity
#17
MULTICENTER STUDY
Sara J Haug, Robert W Wong, Shelley Day, Netan Choudhry, Scott Sneed, Pradeep Prasad, Sarah Read, Richard H McDonald, Anita Agarwal, Janet Davis, David Sarraf
PURPOSE: To report nine new cases of retinal degeneration secondary to didanosine toxicity and to summarize the previously reported cases in the literature. METHODS: This was a multicenter, retrospective, observational case study from seven institutions. Medical records of patients who demonstrated well-demarcated severe midperipheral chorioretinal degeneration and who were previously treated with didanosine therapy were collected and the following information was reviewed: age, gender, medical history, detailed medication history including current and previous antiretroviral use, ocular and retinal examination findings, and multimodal imaging findings with optical coherence tomography, fundus photography, wide-field fundus autofluorescence, and wide-field fluorescein angiography...
December 2016: Retina
https://www.readbyqxmd.com/read/27958287/ocular-radiation-threshold-projection-based-off-of-fluoroscopy-time-during-ercp
#18
Mrinal S Garg, Pikul Patel, Margaret Blackwood, Satish Munigala, Payal Thakkar, James Field, Dustin Wallace, Satty Agarwal, Elie Aoun, Abhijit Kulkarni, Manish Dhawan, Katie Farah, Shyam Thakkar
OBJECTIVES: Current international guidelines for ocular radiation exposure suggest a threshold of 20 millisieverts (mSv)/year. Although endoscopists wear lead aprons, use of protective eye wear is optional. This study was conducted to analyze the lens radiation exposure during endoscopic retrograde cholangiopancreatography (ERCP) for endoscopists to determine the time of fluoroscopy needed to warrant using lens protection during ERCP. METHODS: ERCP patients were prospectively enrolled...
May 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27956280/new-surgical-approach-in-cases-of-cataract-with-ocular-stevens-johnson-syndrome
#19
Namrata Sharma, Neelima Aron, Renu Venugopal, Sushil Sangwan, Jeewan Singh Titiyal, Tushar Agarwal
We describe the intraoperative difficulties encountered in cases of ocular Stevens-Johnson syndrome as a result of a poor ocular surface, the presence of symblepharon, and varying degrees of corneal opacity with secondary poor visibility of anterior segment structures. Modifications to the standard phacoemulsification technique enabled safe and successful completion of the surgery in these cases. FINANCIAL DISCLOSURE: None of the authors has a financial or proprietary interest in any material or method mentioned...
November 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27939560/drusen-like-deposits-in-young-adults-diagnosed-with-systemic-lupus-erythematosus
#20
Alessandro Invernizzi, Laura dell'Arti, Gaia Leone, Daniela Galimberti, Elena Garoli, Gabriella Moroni, Alessandro Santaniello, Aniruddha Agarwal, Francesco Viola
PURPOSE: To determine the prevalence of drusen-like deposits (DLDs) and choroidal changes in patients with systemic lupus erythematosus (SLE), with or without glomerulonephritis; and to correlate ocular findings with systemic features. DESIGN: Case-control study. METHODS: Sixty patients with SLE (age, 18-55 years; 30 with and 30 without SLE-related glomerulonephritis) and 60 age- and sex-matched healthy controls were enrolled. All patients underwent noninvasive multimodal imaging that included fundus photography, near-infrared reflectance, blue autofluorescence, blue reflectance, and spectral-domain optical coherence tomography (SDOCT)...
March 2017: American Journal of Ophthalmology
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