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https://www.readbyqxmd.com/read/28163542/presumed-isotretinoin-induced-extraocular-myopathy
#1
Md Shahid Alam, Swati Agarwal
Isotretinoin a synthetic analogue of vitamin A is primarily used for cystic acne not responding to conventional treatment. Several ocular side effects including blurring of vision, decreased dark adaptation, corneal opacities and meibomian gland atrophy have been reported with prolonged use of isotretinoin. There have been reports of muscular damage caused by isotretinoin. Extra ocular myopathy as an adverse effect of long term used of isotretinoin has never been mentioned in literature. We report a case of a young male who presented to us with complaints of diplopia after using isotretinoin for a prolonged period...
October 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/28112131/polymerase-chain-reaction-for-mycobacterium-tuberculosis-dna-detection-from-ocular-fluids-in-patients-with-various-types-of-choroiditis-in-a-referral-eye-center-in-india
#2
Jyotirmay Biswas, Mohmmad Salman Kazi, Vishvesh Ashokkumar Agarwal, Md Shahid Alam, K Lily Therese
AIMS: The aim of this study was to detect Mycobacterium tuberculosis (MTB) DNA with polymerase chain reaction (PCR) in aqueous or vitreous samples of patients suffering from choroiditis presumed to be infectious origin. SETTINGS AND DESIGN: Hospital-based, retrospective case-control study. SUBJECTS AND METHODS: In all, forty eyes of forty patients with choroiditis divided into two groups - Group A (serpiginous-like choroiditis, ampiginous choroiditis, multifocal choroiditis) and Group B (choroidal abscess, miliary tuberculosis (TB), choroidal tubercle) were analyzed retrospectively...
December 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28012878/viral-posterior-uveitis
#3
REVIEW
Joanne H Lee, Aniruddha Agarwal, Padmamalini Mahendradas, Cecilia S Lee, Vishali Gupta, Carlos E Pavesio, Rupesh Agrawal
The causes of posterior uveitis can be divided into infectious, autoimmune, or masquerade syndromes. Viral infections. a significant cause of sight-threatening ocular diseases in the posterior segment,, include human herpesviruses, measles, rubella, and arboviruses such as dengue, West Nile, and chikungunya virus. Viral posterior uveitis may occur as an isolated ocular disease in congenital or acquired infections or as part of a systemic viral illness. Many viruses remain latent in the infected host with a risk of reactivation that depends on various factors, including virulence and host immunity, age, and comorbidities...
December 21, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28012873/posner-schlossman-syndrome
#4
REVIEW
Roly Megaw, Pankaj Kumar Agarwal
Posner-Schlossman syndrome (PSS), or glaucomatocyclitic crisis, is a unilateral ocular condition characterized by recurrent attacks of non-granulomatous anterior uveitis and raised intraocular pressure that can result in chronic secondary glaucoma. This relatively rare disease is most likely the result of recurrent cytomegalovirus infection and affects predominantly middle-aged males . Diagnosis is largely clinical, with aqueous and blood sampling aiding the identification of any underlying infectious cause...
December 21, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28005674/didanosine-retinal-toxicity
#5
Sara J Haug, Robert W Wong, Shelley Day, Netan Choudhry, Scott Sneed, Pradeep Prasad, Sarah Read, Richard H McDonald, Anita Agarwal, Janet Davis, David Sarraf
PURPOSE: To report nine new cases of retinal degeneration secondary to didanosine toxicity and to summarize the previously reported cases in the literature. METHODS: This was a multicenter, retrospective, observational case study from seven institutions. Medical records of patients who demonstrated well-demarcated severe midperipheral chorioretinal degeneration and who were previously treated with didanosine therapy were collected and the following information was reviewed: age, gender, medical history, detailed medication history including current and previous antiretroviral use, ocular and retinal examination findings, and multimodal imaging findings with optical coherence tomography, fundus photography, wide-field fundus autofluorescence, and wide-field fluorescein angiography...
December 2016: Retina
https://www.readbyqxmd.com/read/27958287/ocular-radiation-threshold-projection-based-off-of-fluoroscopy-time-during-ercp
#6
Mrinal S Garg, Pikul Patel, Margaret Blackwood, Satish Munigala, Payal Thakkar, James Field, Dustin Wallace, Satty Agarwal, Elie Aoun, Abhijit Kulkarni, Manish Dhawan, Katie Farah, Shyam Thakkar
OBJECTIVES: Current international guidelines for ocular radiation exposure suggest a threshold of 20 millisieverts (mSv)/year. Although endoscopists wear lead aprons, use of protective eye wear is optional. This study was conducted to analyze the lens radiation exposure during endoscopic retrograde cholangiopancreatography (ERCP) for endoscopists to determine the time of fluoroscopy needed to warrant using lens protection during ERCP. METHODS: ERCP patients were prospectively enrolled...
December 13, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27956280/new-surgical-approach-in-cases-of-cataract-with-ocular-stevens-johnson-syndrome
#7
Namrata Sharma, Neelima Aron, Renu Venugopal, Sushil Sangwan, Jeewan Singh Titiyal, Tushar Agarwal
: We describe the intraoperative difficulties encountered in cases of ocular Stevens-Johnson syndrome as a result of a poor ocular surface, the presence of symblepharon, and varying degrees of corneal opacity with secondary poor visibility of anterior segment structures. Modifications to the standard phacoemulsification technique enabled safe and successful completion of the surgery in these cases. FINANCIAL DISCLOSURE: None of the authors has a financial or proprietary interest in any material or method mentioned...
November 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27939560/drusen-like-deposits-in-young-adults-diagnosed-with-systemic-lupus-erythematosus
#8
Alessandro Invernizzi, Laura dell'Arti, Gaia Leone, Daniela Galimberti, Elena Garoli, Gabriella Moroni, Alessandro Santaniello, Aniruddha Agarwal, Francesco Viola
PURPOSE: To determine the prevalence of drusen-like deposits (DLDs) and choroidal changes in patients with Systemic Lupus Erythematosus (SLE), with or without glomerulonephritis. To correlate ocular findings with systemic features. DESIGN: Case-control study METHODS: Sixty patients with SLE (18-55 years; 30 with and 30 without SLE-related glomerulonephritis) and 60 age and gender matched healthy controls were enrolled. All patients underwent non-invasive, multimodal imaging that included fundus photography, near-infrared reflectance, blue autofluorescence, blue reflectance, and spectral-domain optical coherence tomography (SD-OCT)...
December 6, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27888495/an-unusual-presentation-of-intraocular-tuberculosis-in-a-monocular-patient-clinicopathological-correlation
#9
Kanika Aggarwal, Aniruddha Agarwal, Shobha Sehgal, Suryaprakash Sharma, Nirbhai Singh, Kusum Sharma, Ramanuj Samanta, Alessandro Invernizzi, Aman Sharma, Vishali Gupta
BACKGROUND: Lack of uniform diagnostic criteria often poses a challenge in the diagnosis and management of tubercular uveitis. The index case describes an unusual presentation of tubercular panuveitis initially misdiagnosed as sympathetic ophthalmia, where the appropriate diagnosis was made using various imaging and laboratory investigations. RESULTS: A 52-year-old Indian woman underwent multimodal imaging, extensive clinical and laboratory work-up, and analysis of microbiological and histopathological specimens...
December 2016: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/27863187/cytology-of-primary-vaginal-melanoma-an-unusual-report-on-fine-needle-aspiration
#10
Poojan Agarwal, Manju Kaushal
Primary malignant melanoma of the vagina is an extremely uncommon malignancy comprising of less than 10% malignancies of the female genital tract and 0.3% of all melanomas. Melanoblasts are neural crest derivatives and are notorious for causing primary cutaneous neoplasms. However, they involve virtually every organ of the body including eye, intestines and ocular mucosa, probably due to aberrancies in cell migration. Vagina is a rare site and primary melanoma of the vagina occurs in postmenopausal women with vaginal discharge, bleeding, or mass as common presenting complaints...
November 11, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27849402/a-review-of-the-role-of-intravitreal-corticosteroids-as-an-adjuvant-to-antibiotics-in-infectious-endophthalmitis
#11
Dawn Ching Wen Ho, Aniruddha Agarwal, Cecilia S Lee, Jay Chhablani, Vishali Gupta, Manoj Khatri, Jayabalan Nirmal, Carlos Pavesio, Rupesh Agrawal
Infectious endophthalmitis is an important cause of vision loss worldwide. This entity most often occurs as a complication of intraocular surgery especially following cataract surgery or intravitreal injection. Endophthalmitis is regarded as a serious complication following ocular surgery and the final visual outcome is fundamentally contingent on timely recognition and intervention. Intravitreal and oral antibiotics in combination with pars plana vitrectomy or vitreous aspiration remain the mainstay in the management of endophthalmitis...
November 16, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27726520/multimodal-imaging-in-ocular-tuberculosis
#12
Aniruddha Agarwal, Sarakshi Mahajan, Moncef Khairallah, Padmamalini Mahendradas, Amod Gupta, Vishali Gupta
Intraocular tuberculosis presents a diagnostic challenge because of its protean clinical manifestations. Thus, it becomes imperative to distinguish chorioretinal inflammation due to tuberculosis from other infectious as well as non-infectious posterior uveitis since the clinical manifestations of these entities may be quite similar. With advancing technology, a number of novel imaging modalities are available today that enable in vivo near-histologic assessment of the chorioretinal tissue, greatly aiding the clinician in establishing a diagnosis and monitoring the therapeutic response of tubercular lesions...
February 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27595117/correlation-between-tear-fluid-and-serum-vitamin-d-levels
#13
Swaminathan Sethu, Rohit Shetty, Kalyani Deshpande, Natasha Pahuja, Nandini Chinnappaiah, Aarti Agarwal, Anupam Sharma, Arkasubhra Ghosh
BACKGROUND: Vitamin D deficiency is associated with a range of systemic diseases including ocular disorders. The objective of this study is to measure tear vitamin D levels and investigate the correlation between serum and tear vitamin D levels. METHODS: A total of 48 healthy volunteers without any systemic and ocular disease were recruited for this observational cohort study. Serum was collected using clot activator coated Vacutainer® Plus tubes. Tear fluid was collected using Schirmer's strips...
2016: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/27494951/assessment-of-retinal-vascular-calibres-as-a-biomarker-of-disease-activity-in-birdshot-chorioretinopathy
#14
Rupesh Agrawal, Nichole Joachim, Ling-Jun Li, Jiaying Lee, Aniruddha Agarwal, Dawn A Sim, Pearse A Keane, Gerald Liew, Carlos E Pavesio
PURPOSE: Birdshot chorioretinopathy (BCR) is a potentially blinding ocular disorder involving the retinal vasculature and choroid without any systemic manifestations. The objective of the study was to describe vascular calibre changes in BCR and analyse the possibility of this optical biomarker for staging and monitoring disease activity in BCR. METHODS: This retrospective case-control study at a tertiary referral eye centre in the UK included 33 eyes from 21 patients with BCR and equal number of eyes from control subjects...
March 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27327041/corneal-toxicity-induced-by-vesicating-agents-and-effective-treatment-options
#15
Dinesh G Goswami, Neera Tewari-Singh, Rajesh Agarwal
The vesicating agents sulfur mustard (SM) and lewisite (LEW) are potent chemical warfare agents that primarily cause damage to the ocular, skin, and respiratory systems. However, ocular tissue is the most sensitive organ, and vesicant exposure results in a biphasic injury response, including photophobia, corneal lesions, corneal edema, ulceration, and neovascularization, and may cause loss of vision. There are several reports on ocular injury from exposure to SM, which has been frequently used in warfare. However, there are very few reports on ocular injury by LEW, which indicate that injury symptoms appear instantly after exposure and faster than SM...
June 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27176114/optical-coherence-tomography-angiography-a-non-invasive-tool-to-image-end-arterial-system
#16
EDITORIAL
Rupesh Agrawal, Wei Xin, Pearse A Keane, Jay Chhablani, Aniruddha Agarwal
No abstract text is available yet for this article.
June 2016: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/27127902/retinal-neovascularisation-in-susac-syndrome-a-rare-complication
#17
Kshitiz Kumar, Bhavini Jariwala, Pallavi Raj, Amar Agarwal
PURPOSE: To report a case of Susac syndrome with ocular complications in the chronic stage of the disease. METHODS: Case report. RESULTS: A 37-year-old male patient of Indian origin presented with painless blurring of vision in the right eye. Ophthalmoscopic examination revealed vitreous hemorrhage in the right eye and NVE in both eyes well-documented angiographically. Old medical records revealed a previous attack of bilateral BRAO as a complete triad of Susac syndrome 10 years before, with an uncomplicated clinical course...
April 29, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/27124779/conjunctival-microbial-flora-in-ocular-stevens-johnson-syndrome-sequelae-patients-at-a-tertiary-eye-care-center
#18
Renu Venugopal, Gita Satpathy, Sushil Sangwan, Arti Kapil, Neelima Aron, Tushar Agarwal, Neelam Pushker, Namrata Sharma
PURPOSE: To evaluate the conjunctival microbial flora in cases of ocular Stevens-Johnson Syndrome (SJS) in a tertiary eye care center. METHODS: This prospective study comprised 176 eyes of 88 patients with ocular SJS compared with 124 eyes of normal subjects. The conjunctival swabs were collected and sent for microbiological analysis for bacterial isolation and antibiotic sensitivity examination. The type of bacteria isolated and its antibiotic sensitivity pattern were studied...
August 2016: Cornea
https://www.readbyqxmd.com/read/27093100/cross-linking-for-microbial-keratitis
#19
REVIEW
Tommy C Y Chan, Tushar Agarwal, Rasik B Vajpayee, Vishal Jhanji
PURPOSE OF REVIEW: Microbial keratitis is one of the leading causes of ocular morbidity. The standard treatment consists of antibiotics, which is intensive and is fraught with risks of antibiotic resistance. Corneal collagen cross-linking (CXL) has recently been advocated as an adjunctive therapy for management of microbial keratitis. The addition of CXL to ongoing antimicrobial treatment can have a potential effect on overall duration of the disease, need for corneal transplantation, final visual outcome, and long-term impact on drug resistance pattern...
July 2016: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/27080149/modern-approaches-to-the-ocular-delivery-of-cyclosporine-a
#20
REVIEW
Priyanka Agarwal, Ilva D Rupenthal
Cyclosporine A (CsA) has long been the mainstay treatment for dry eye syndrome (DES), one of the most common disorders of the eye. However, the poor water solubility of CsA renders it difficult to formulate it into topical ocular dosage forms. Restasis® is currently the only US Food and Drug Administration (FDA)-approved CsA formulation, while Ikervis® has recently been launched in Europe, with both commonly associated with severe ocular discomfort. Therefore, several CsA formulations have been investigated with the aim to improve bioavailability while reducing adverse effects associated with the marketed formulations...
June 2016: Drug Discovery Today
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