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https://www.readbyqxmd.com/read/28923717/production-of-d-tagatose-and-bioethanol-from-onion-waste-by-an-intergrating-bioprocess
#1
Ho Myeong Kim, Younho Song, Seung Gon Wi, Hyeun-Jong Bae
The rapid increase of agricultural waste is becoming a burgeoning problem and considerable efforts are being made by numerous researchers to convert it into a high-value resource material. Onion waste is one of the biggest issues in a world of dwindling resource. In this study, the potential of onion juice residue (OJR) for producing valuable rare sugar or bioethanol was evaluated. Purified Paenibacillus polymyxaL-arabinose isomerase (PPAI) has a molecular weight of approximately 53kDa, and exhibits maximal activity at 30°C and pH 7...
September 15, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28921830/trends-application-and-future-prospectives-of-microbial-carbonic-anhydrase-mediated-carbonation-process-for-ccus
#2
REVIEW
Chintan Bhagat, Pravin Dudhagara, Shantilal Tank
Growing industrialisation and desire for better economy of countries accelerated the emission of greenhouse gasses, more than the buffering capacity of earth atmosphere. Among, various Green House Gasses (GHGs), CO2 occupies the first position in anthroposphere and has detrimental effects on the ecosystem. For decarbonization, several non-biological methods of carbon capture, utilisation, and storage (CCUS) are in use from last few decades, but they are suffering from narrow applicability. Recently, CO2 emission and its disposal related problem encourage for implementation of bioprocessing to achieve zero waste economy for a sustainable environment...
September 18, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28921534/exploring-cellular-behaviour-under-transient-gene-expression-and-its-impact-on-mab-productivity-and-fc-glycosylation
#3
Si Nga Sou, Ken Lee, Kalpana Nayyar, Karen M Polizzi, Christopher Sellick, Cleo Kontoravdi
Transient gene expression (TGE) is a methodology employed in bioprocessing for the fast provision of recombinant protein material. Mild hypothermia is often introduced to overcome the low yield typically achieved with TGE and improve specific protein productivity. It is therefore of interest to examine the impact of mild hypothermic temperatures on both the yield and quality of transiently-expressed proteins and the relationship to changes in cellular processes and metabolism. In this study, we focus on the ability of a Chinese hamster ovary cell line to galactosylate a recombinant monoclonal antibody (mAb) product...
September 16, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28921339/biotechnological-production-of-value-added-compounds-by-ustilaginomycetous-yeasts
#4
REVIEW
Bruno N Paulino, Marina G Pessôa, Gustavo Molina, Antônio A Kaupert Neto, Juliana V C Oliveira, Mario C R Mano, Glaucia M Pastore
The use of yeasts in bioprocesses can be considered one of the most relevant strategies in industrial biotechnology, and their potential is recognized due to the ability of these microorganisms for production of diverse value-added compounds. Yeasts from Ustilaginaceae family have been highlighted in the last years as a promising source of industrial interesting compounds, including enzymes, sugars, lipids, organic acids, and biosurfactants. These compounds may exhibit various applications in pharmaceutical, cosmetic, food, medical, and environmental fields, increasing the scientific attention in the study of ustilaginomycetous for biotechnological purposes...
September 18, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28919928/the-yeast-geotrichum-candidum-encodes-functional-lytic-polysaccharide-monooxygenases
#5
Simon Ladevèze, Mireille Haon, Ana Villares, Bernard Cathala, Sacha Grisel, Isabelle Herpoël-Gimbert, Bernard Henrissat, Jean-Guy Berrin
BACKGROUND: Lytic polysaccharide monooxygenases (LPMOs) are a class of powerful oxidative enzymes that have revolutionized our understanding of lignocellulose degradation. Fungal LPMOs of the AA9 family target cellulose and hemicelluloses. AA9 LPMO-coding genes have been identified across a wide range of fungal saprotrophs (Ascomycotina, Basidiomycotina, etc.), but so far they have not been found in more basal lineages. Recent genome analysis of the yeast Geotrichum candidum (Saccharomycotina) revealed the presence of several LPMO genes, which belong to the AA9 family...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28919737/bacterial-membrane-vesicles-as-novel-nanosystems-for-drug-delivery
#6
REVIEW
Sapna Jain, Jonathan Pillai
Bacterial membrane vesicles (BMVs) are closed spherical nanostructures that are shed naturally and ubiquitously by most bacterial species both in vivo and in vitro. Researchers have elucidated their roles in long-distance transport of a wide array of cargoes, such as proteins, toxins, antigens, virulence factors, microbicidal agents and antibiotics. Given that these natural carriers are important players in intercellular communication, it has been hypothesized that they are equally well attuned for transport and delivery of exogenous therapeutic cargoes...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28917732/staying-alive-sensors-used-for-monitoring-cell-health-in-bioreactors
#7
REVIEW
P O'Mara, A Farrell, J Bones, K Twomey
Current and next generation sensors such as pH, dissolved oxygen (dO) and temperature sensors that will help drive the use of single-use bioreactors in industry are reviewed. The current trend in bioreactor use is shifting from the traditional fixed bioreactors to the use of single-use bioreactors (SUBs). However as the shift in paradigm occurs there is now a greater need for sensor technology to play 'catch up' with the innovation of bioreactor technology. Many of the sensors still in use today rely on technology created in the 1960's such as the Clark-type dissolved oxygen sensor or glass pH electrodes...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28913699/morphological-analysis-of-the-filamentous-fungus-penicillium-chrysogenum-using-flow-cytometry-the-fast-alternative-to-microscopic-image-analysis
#8
Daniela Ehgartner, Christoph Herwig, Jens Fricke
An important parameter in filamentous bioreactor cultivations is the morphology of the fungi, due to its interlink to productivity and its dependency on process conditions. Filamentous fungi show a large variety of morphological forms in submerged cultures. These range from dispersed hyphae, to interwoven mycelial aggregates, to denser hyphal aggregates, the so-called pellets. Depending on the objective function of the bioprocess, different characteristics of the morphology are favorable and need to be quantified accurately...
September 14, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28904563/bacillus-coagulans-ma-13-a-promising-thermophilic-and-cellulolytic-strain-for-the-production-of-lactic-acid-from-lignocellulosic-hydrolysate
#9
Martina Aulitto, Salvatore Fusco, Simonetta Bartolucci, Carl Johan Franzén, Patrizia Contursi
BACKGROUND: The transition from a petroleum-based economy towards more sustainable bioprocesses for the production of fuels and chemicals (circular economy) is necessary to alleviate the impact of anthropic activities on the global ecosystem. Lignocellulosic biomass-derived sugars are suitable alternative feedstocks that can be fermented or biochemically converted to value-added products. An example is lactic acid, which is an essential chemical for the production of polylactic acid, a biodegradable bioplastic...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28903770/a-novel-bi-directional-promoter-system-allows-tunable-recombinant-protein-production-in-pichia-pastoris
#10
Vignesh Rajamanickam, Karl Metzger, Christian Schmid, Oliver Spadiut
BACKGROUND: The methylotrophic yeast Pichia pastoris is a well-studied host organism for recombinant protein production, which is usually regulated either by a constitutive promoter (e.g. promoter of glyceraldehyde-3-phosphate dehydrogenase; PGAP) or an inducible promoter (e.g. promoter of alcohol oxidase 1; PAOX1). Both promoter systems have several advantages and disadvantages; with one of the main disadvantages being their lack of tunability. Various novel promoter systems, which are either inducible or de-repressed, allowing higher degrees of freedom, have been reported...
September 13, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28900797/improvement-of-chia-seeds-with-antioxidant-activity-gaba-essential-amino-acids-and-dietary-fiber-by-controlled-germination-bioprocess
#11
Mario Armando Gómez-Favela, Roberto Gutiérrez-Dorado, Edith Oliva Cuevas-Rodríguez, Vicente Adrián Canizalez-Román, Claudia Del Rosario León-Sicairos, Jorge Milán-Carrillo, Cuauhtémoc Reyes-Moreno
Chia (Salvia hispanica L.) plant is native from southern Mexico and northern Guatemala. Their seeds are a rich source of bioactive compounds which protect consumers against chronic diseases. Germination improves functionality of the seeds due to the increase in the bioactive compounds and associated antioxidant activity. The purpose of this study was to obtain functional flour from germinated chia seeds under optimized conditions with increased antioxidant activity, phenolic compounds, GABA, essential amino acids, and dietary fiber with respect to un-germinated chia seeds...
September 12, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/28898853/partially-consolidated-bioprocessing-of-mixed-lignocellulosic-feedstocks-for-ethanol-production
#12
Avanthi Althuri, Lohit Kumar Srinivas Gujjala, Rintu Banerjee
Rapid urbanization and industrialization have accelerated the energy demand which cannot be met by decreasing fossil fuels thereby substantiate the need for lignocellulosic ethanol. The present study is one such attempt towards bioethanol production in an eco-friendly manner using enzymes in which a mixture of lignocellulosic biomass namely, Ricinus communis, Saccharum officinarum (tops) and Saccharum spontaneum were taken as a substrate. The mixed biomass was processed through partially consolidated bioprocessing (PCBP) approach which involves a non-isothermal simultaneous pretreatment and saccharification step where a concoction of laccase (Pleurotus djamor) and holocellulase (Trichoderma reseei RUT C30) was used followed by co-fermentation within the same reactor...
August 24, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28898788/molecular-modelling-and-quantum-biochemistry-computations-of-a-naturally-occurring-bioremediation-enzyme-alkane-hydroxylase-from-pseudomonas-putida-p1
#13
B G de Sousa, J I N Oliveira, E L Albuquerque, U L Fulco, V E Amaro, C A G Blaha
Many species of bacteria involved in degradation of n-alkanes have an important constitutional metabolic enzyme, the alkane hydroxylase called AlkB, specialized in the conversion of hydrocarbons molecules that can be used as carbon and/or energy source. This enzyme plays an important role in the microbial degradation of oil, chlorinated hydrocarbons, fuel additives, and many other compounds. A number of these enzymes has been biochemically characterized in detail because the potential of alkane hydroxylases to catalyse high added-value reactions is widely recognized...
September 1, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28892667/bioprocess-engineering-for-biohythane-production-from-low-grade-waste-biomass-technical-challenges-towards-scale-up
#14
REVIEW
Zhidan Liu, Buchun Si, Jiaming Li, Jianwei He, Chong Zhang, Yuan Lu, Yuanhui Zhang, Xin-Hui Xing
A concept of biohythane production by combining biohydrogen and biomethane together via two-stage anaerobic fermentation (TSAF) has been recently proposed and considered as a promising approach for sustainable hythane generation from waste biomass. The advantage of biohythane over traditional biogas are more environmentally benign, higher energy recovery and shorter fermentation time. However, many of current efforts to convert waste biomass into biohythane are still at the bench scale. The system bioprocess study and scale up for industrial application are indispensable...
September 8, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28890405/additive-biotech-chances-challenges-and-recent-applications-of-additive-manufacturing-technologies-in-biotechnology
#15
REVIEW
Felix Krujatz, Anja Lode, Julia Seidel, Thomas Bley, Michael Gelinsky, Juliane Steingroewer
The diversity and complexity of biotechnological applications are constantly increasing, with ever expanding ranges of production hosts, cultivation conditions and measurement tasks. Consequently, many analytical and cultivation systems for biotechnology and bioprocess engineering, such as microfluidic devices or bioreactors, are tailor-made to precisely satisfy the requirements of specific measurements or cultivation tasks. Additive manufacturing (AM) technologies offer the possibility of fabricating tailor-made 3D laboratory equipment directly from CAD designs with previously inaccessible levels of freedom in terms of structural complexity...
September 7, 2017: New Biotechnology
https://www.readbyqxmd.com/read/28888551/amino-acids-production-focusing-on-fermentation-technologies-a-review
#16
REVIEW
Martina D'Este, Merlin Alvarado-Morales, Irini Angelidaki
Amino acids are attractive and promising biochemicals with market capacity requirements constantly increasing. Their applicability ranges from animal feed additives, flavour enhancers and ingredients in cosmetic to specialty nutrients in pharmaceutical and medical fields. This review gives an overview of the processes applied for amino acids production and points out the main advantages and disadvantages of each. Due to the advances made in the genetic engineering techniques, the biotechnological processes, and in particular the fermentation with the aid of strains such as Corynebacterium glutamicum or Escherichia coli, play a significant role in the industrial production of amino acids...
September 6, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28887417/high-substrate-uptake-rates-empower-vibrio-natriegens-as-production-host-for-industrial-biotechnology
#17
Eugenia Hoffart, Sebastian Grenz, Julian Lange, Robert Nitschel, Felix Müller, Andreas Schwentner, André Feith, Mira Lenfers-Lücker, Ralf Takors, Bastian Blombach
The productivity of industrial fermentation processes is essentially limited by the biomass specific substrate consumption rate (qS) of the applied microbial production system. Since qS depends on the growth rate (μ), we highlight the potential of the fastest growing non-pathogenic bacterium, Vibrio natriegens, as novel candidate for future biotechnological processes. V. natriegens grows rapidly in BHIN complex medium with a μ of up to 4.43 h(-1) (doubling time of 9.4 min) as well as in minimal medium supplemented with various industrially relevant substrates...
September 8, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28884679/the-integration-of-a-macrophage-adapted-live-vaccine-strain-of-equine-infectious-anaemia-virus-eiav-in-the-horse-genome
#18
Qiang Liu, Xue-Feng Wang, Cheng Du, Yue-Zhi Lin, Jian Ma, Yu-Hong Wang, Jian-Hua Zhou, Xiaojun Wang
Integration is an important feature of retroviruses and retrovirus-based therapeutic transfection vectors. The non-primate lentivirus equine infectious anaemia virus (EIAV) primarily targets macrophages/monocytes in vivo. Investigation of the integration features of EIAVDLV121 strains, which are adapted to donkey monocyte-derived macrophages (MDMs), is of great interest. In this study, we analysed the integration features of EIAVDLV121 in equine MDMs during in vitro infection. Our previously published integration sites (IS) for EIAVFDDV13 in fetal equine dermal (FED) cells were also analysed in parallel as references...
September 7, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28884522/development-of-a-high-throughput-microscale-cell-disruption-platform-for-pichia-pastoris-in-rapid-bioprocess-design
#19
Benjamin A F Bláha, Stephen A Morris, Olotu W Ogonah, Vincenzo Crescente, William Rosenberg, Sophie Maucourant, Tarit K Mukhopadhyay
The time and cost benefits of miniaturized fermentation platforms can only be gained by employing complementary techniques facilitating high-throughput at small sample volumes. Microbial cell disruption is a major bottleneck in experimental throughput and is often restricted to large processing volumes. Moreover, for rigid yeast species such as Pichia pastoris, no effective high-throughput disruption methods exist. This study describes the development of an automated, miniaturized, high-throughput, non-contact, scalable platform based on Adaptive Focused Acoustics (AFA) to disrupt P...
September 7, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28884384/study-of-chir-function-in-serratia-marcescens-and-its-application-for-improving-2-3-butanediol-from-crystal-chitin
#20
Qiang Yan, Eunsoo Hong, Stephen S Fong
Microbial utilization of chitin, a potential renewable biomass feedstock, is being pursued as a means of developing novel consolidated bioprocessing for the production of chemicals. Serratia marcescens is a gram-negative bacterium that is known for its chitinolytic capability and as a native 2,3-butanediol producer. In S. marcescens, ChiR has been suggested to be a positive regulator of chitinase production. In this study, we aim to understand the effect of ChiR in regulating nine chitinase-related genes in S...
September 8, 2017: Applied Microbiology and Biotechnology
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