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JOURNAL ARTICLE
Krzysztof Korzeniewski
BACKGROUND: After COVID-19 restrictions were lifted, people started to travel again. Each year, thousands of Poles travel internationally, and many travel to tropical or subtropical destinations in Asia, Africa or South America. The aim of this article was to describe the characteristics of Polish travellers based on the information from a retrospective 12-month review of the medical records of Polish patients seeking pre-travel advice at the largest diagnostic and treatment travel medicine centre in Poland in 2023...
2024: International Maritime Health
#2
Amira Mohamed Taha, Khaled Abouelmagd, Abdelrahman Mohamed Mahmoud, Mohamed Hamouda Elkasaby, Dang Nguyen, Ryan Ahmed, Pari Patel, D Katterine Bonilla-Aldana, Camila Luna, Alfonso J Rodriguez-Morales
BACKGROUND: The Vi-diphtheria toxoid typhoid conjugate vaccine (Vi-DT) has shown promising results in preventing typhoid fever in children under 2 years of age. However, a thorough assessment of its safety and immunogenicity is required to inform vaccination strategies. This systematic review and meta-analysis aimed to determine the safety and immunogenicity of Vi-DT in children below 2 years. METHODS: We systematically searched multiple databases, including PubMed, Web of Science, and Scopus, for relevant studies published up to September 2023...
2024: Frontiers in Microbiology
#3
JOURNAL ARTICLE
Seung Y Lee, Annaleise R Howard-Jones, Venkata Ln Lavu, Sophie Norton, Vitali Sintchenko, Philip N Britton, Shopna Bag, Ameneh Khatami
OBJECTIVES: Enteric fever carries appreciable morbidity in non-endemic settings, particularly in returned travelers. This study aimed to characterize the healthcare burden of enteric fever in a low-incidence setting and to identify risk factors and opportunities for preventative interventions. METHODS: Analysis of a retrospective case series from a tertiary pediatric center (2015-2019), augmented by public health notification and microbiological laboratory data (2018-2019), from Western Sydney, Australia, a region with frequent travel links to South Asia...
April 19, 2024: Infectious diseases now
#4
JOURNAL ARTICLE
Kishore R Alugupalli
Activation of the adaptive immune system requires the engagement of costimulatory pathways in addition to B and T cell Ag receptor signaling, and adjuvants play a central role in this process. Many Gram-negative bacterial polysaccharide vaccines, including the tetravalent meningococcal conjugate vaccines (MCV4) and typhoid Vi polysaccharide vaccines, do not incorporate adjuvants. The immunogenicity of typhoid vaccines is due to the presence of associated TLR4 ligands in these vaccines. Because the immunogenicity of MCV4 is poor and requires boosters, I hypothesized that TLR4 ligands are absent in MCV4 and that incorporation of a TLR4 ligand-based adjuvant would improve their immunogenicity...
April 1, 2024: ImmunoHorizons
#5
JOURNAL ARTICLE
Zaeem Ul Haq, Soofia Yunus, Naveed Jafri
In a health emergency, governments rely on public trust in their policy, and anticipate its compliance to protect health and save lives. Vaccine hesitancy compromises this process when an emergency involves infections. The prevailing discourse on vaccine hesitancy often describes it as a static phenomenon, ignoring its expanse and complexity, and neglecting the exploration of tools to address it. This article diverges from the conventional perspective by explaining the case of Pakistan and its communication strategy for the COVID-19 vaccine...
April 10, 2024: BMJ Global Health
#6
JOURNAL ARTICLE
Ezzati Ghadi Fereshteh, Roudbari Zahra, Razavi Razieh
Consumption of contaminated water and foods by Salmonella Typhi cause the most common enteric disease known as Typhoid fever in both humans and animals. Despite the existence of various vaccines but infectious diseases remain a major cause of mortality worldwide. Nowadays, in-silico tools design a reliable and stable vaccine to combat such infections. The study aimed to design and evaluate a multi-epitope vaccine based on the outer-membrane proteins of Salmonella Typhi. B-cells and T-cells epitopes were predicted...
October 2023: Archives of Razi Institute
#7
JOURNAL ARTICLE
Filippo Queirazza, Jonathan Cavanagh, Marios G Philiastides, Rajeev Krishnadas
BACKGROUND: Altered neural haemodynamic activity during decision making and learning has been linked to the effects of inflammation on mood and motivated behaviours. So far, it has been reported that blunted mesolimbic dopamine reward signals are associated with inflammation-induced anhedonia and apathy. Nonetheless, it is still unclear whether inflammation impacts neural activity underpinning decision dynamics. The process of decision making involves integration of noisy evidence from the environment until a critical threshold of evidence is reached...
March 29, 2024: Brain, Behavior, and Immunity
#8
JOURNAL ARTICLE
Rubhana Raqib
No abstract text is available yet for this article.
March 28, 2024: Lancet
#9
JOURNAL ARTICLE
Prasad S Kulkarni, Anirudha Vyankatesh Potey, Sandesh Bharati, Anil Kunhihitlu, Bharath Narasimha, Sindhu Yallapa, Abhijeet Dharmadhikari, Vinay Gavade, Chandrashekhar D Kamat, Asha Mallya, Annamraju D Sarma, Sunil Goel, Sambhaji S Pisal, Cyrus S Poonawalla, Rajaram Venkatesan, Elizabeth Jones, Amy Flaxman, Young Chan Kim, Andrew J Pollard
BACKGROUND: Enteric fever caused by Salmonella enterica Typhi and Salmonella Paratyphi A is an important public health problem, especially in low-income and middle-income countries with limited access to safe water and sanitation. We present results from, to our knowledge, the first ever human study of a bivalent paratyphoid A-typhoid conjugate vaccine (Sii-PTCV). METHODS: In this double-blind phase 1 study, 60 healthy Indian adults were randomly assigned (1:1) to receive a single intramuscular dose of either Sii-PTCV or typhoid conjugate vaccine (Typbar-TCV)...
March 28, 2024: Lancet
#10
JOURNAL ARTICLE
Akshayata Naidu, Varin Garg, Deepna Balakrishnan, Vinaya C R, Vino Sundararajan, Sajitha Lulu S
AIM: We investigated the molecular underpinnings of variation in immune responses to the live attenuated typhoid vaccine (Ty21a) by analyzing the baseline immunological profile. We utilized gene expression datasets obtained from the Gene Expression Omnibus (GEO) database (accession number: GSE100665) before and after immunization. We then employed two distinct computational approaches to identify potential baseline biomarkers associated with responsiveness to the Ty21a vaccine. MAIN METHODS: The first pipeline (knowledge-based) involved the retrieval of differentially expressed genes (DEGs), functional enrichment analysis, protein-protein interaction network construction, and topological network analysis of post-immunization datasets before gauging their pre-vaccination expression levels...
March 28, 2024: Molecular Immunology
#11
JOURNAL ARTICLE
Leah Sukri, Audry Banza, Katherine Shafer, Yakoubou Sanoussi, Kathleen M Neuzil, Rachid Sani
Typhoid intestinal perforation (TIP) is a leading cause of peritonitis and indication for emergency surgery in Africa, with reported mortality rates up to 30% in pediatric patients. Currently, data on TIP in Western databases are primarily from countries that speak English, likely due to non-English publication and citation biases. Despite the high burden of infectious diseases in Francophone Africa, data from these countries regarding TIP remain limited. This study aims to highlight the incidence and morbidity of TIP in Francophone African countries using an extended search algorithm...
2024: PLOS Glob Public Health
#12
REVIEW
Paul Barrow
Despite major progress in the last several decades in reducing the public and animal health burden of infectious disease a number of issues remain to be resolved and which have thus far been regarded as intractable. These include (i) the persistent carrier state in individuals convalescent from typhoid and typhoid-like infections, (ii) the increasing prevalence of multi-antibiotic resistance in enteric pathogens, much of which is mediated by self-transmissible plasmids, and (iii) parasite infections which are difficult to control by vaccination and where resistance to chemotherapeutics is also increasing...
February 20, 2024: Microorganisms
#13
JOURNAL ARTICLE
Christopher Weyant, Yogesh Hooda, Sira Jam Munira, Nathan C Lo, Theresa Ryckman, Arif M Tanmoy, Naito Kanon, Jessica C Seidman, Denise Garrett, Samir K Saha, Jeremy D Goldhaber-Fiebert, Senjuti Saha, Jason R Andrews
PURPOSE: Typhoid fever causes substantial morbidity and mortality in Bangladesh. The government of Bangladesh plans to introduce typhoid conjugate vaccines (TCV) in its expanded program on immunization (EPI) schedule. However, the optimal introduction strategy in addition to the costs and benefits of such a program are unclear. METHODS: We extended an existing mathematical model of typhoid transmission to integrate cost data, clinical incidence data, and recently conducted serosurveys in urban, semi-urban, and rural areas...
March 25, 2024: Vaccine
#14
REVIEW
Tammy Allen, Maria Eugenia Castellanos, Paul Giacomin, Nadira D Karunaweera, Andreas Kupz, Juan Carlos LoL, Dileep Sharma, Suchandan Sikder, Bemnet Tedla, Liza van Eijk, Danica Vojisavljevic, Guangzu Zhao, Saparna Pai
Tropical infectious diseases inflict an unacceptable burden of disease on humans living in developing countries. While anti-pathogenic drugs have been widely used, they carry a constant threat of selecting for resistance. Vaccines offer a promising means by which to enhance the global control of tropical infectious diseases, but these have been difficult to develop, mostly due to the complex nature of the pathogen lifecycles. Here, we present recently developed vaccine candidates for five tropical infectious diseases in the form of a catalogue, that have either entered clinical trials or have been licenced for use...
March 16, 2024: International Journal of Infectious Diseases: IJID
#15
JOURNAL ARTICLE
Florian Marks, Justin Im, Se Eun Park, Gi Deok Pak, Hyon Jin Jeon, Lady Rosny Wandji Nana, Marie-France Phoba, Lisette Mbuyi-Kalonji, Ondari D Mogeni, Biruk Yeshitela, Ursula Panzner, Ligia María Cruz Espinoza, Tigist Beyene, Michael Owusu-Ansah, Sampson Twumasi-Ankrah, Melese Yeshambaw, Ashenafi Alemu, Oluwafemi J Adewusi, Olukemi Adekanmbi, Ellen Higginson, Akinlolu Adepoju, Sarah Agbi, Enoch G Cakpo, Veronica O Ogunleye, Gaëlle Nkoji Tunda, Odion O Ikhimiukor, Jules Mbuyamba, Trevor Toy, Francis Opoku Agyapong, Isaac Osei, John Amuasi, Tsiriniaina Jean Luco Razafindrabe, Tiana Mirana Raminosoa, Gabriel Nyirenda, Njariharinjakampionona Randriamampionona, Hyeong Won Seo, Hyejin Seo, Mohamadou Siribie, Megan E Carey, Michael Owusu, Christian G Meyer, Ndrainaharimira Rakotozandrindrainy, Nimarko Sarpong, Mathilde Razafindrakalia, Ravomialisoa Razafimanantsoa, Moussa Ouedraogo, Yeonseon J Kim, Jooah Lee, Raphaël M Zellweger, Sophie S Y Kang, Ju Yeon Park, John A Crump, Liselotte Hardy, Jan Jacobs, Denise O Garrett, Jason R Andrews, Nimesh Poudyal, Deok Ryun Kim, John D Clemens, Stephen G Baker, Jerome H Kim, Gordon Dougan, Jonathan D Sugimoto, Sandra Van Puyvelde, Aderemi Kehinde, Oluwafemi A Popoola, Vittal Mogasale, Robert F Breiman, William R MacWright, Abraham Aseffa, Birkneh Tilahun Tadesse, Andrea Haselbeck, Yaw Adu-Sarkodie, Mekonnen Teferi, Abdramane Soura Bassiahi, Iruka N Okeke, Octavie Lunguya-Metila, Ellis Owusu-Dabo, Raphaël Rakotozandrindrainy
BACKGROUND: Typhoid Fever remains a major cause of morbidity and mortality in low-income settings. The Severe Typhoid in Africa programme was designed to address regional gaps in typhoid burden data and identify populations eligible for interventions using novel typhoid conjugate vaccines. METHODS: A hybrid design, hospital-based prospective surveillance with population-based health-care utilisation surveys, was implemented in six countries in sub-Saharan Africa...
April 2024: Lancet Global Health
#16
JOURNAL ARTICLE
Rabab Batool, Zoya Haq Qamar, Rehana Abdus Salam, Mohammad Tahir Yousafzai, Per Ashorn, Farah Naz Qamar
BACKGROUND: Typhoid is a serious public health threat in many low-income and middle-income countries. Several vaccines for typhoid have been recommended by WHO for typhoid prevention in endemic countries. This study aimed to review the efficacy of typhoid vaccines against culture-confirmed Salmonella enterica serovar Typhi. METHODS: We searched the Cochrane Central Register of Controlled Trials, MEDLINE, and Embase for studies published in English between Jan 1, 1986 and Nov 2, 2023...
April 2024: Lancet Global Health
#17
JOURNAL ARTICLE
Samuel Kariuki, Robert S Onsare
No abstract text is available yet for this article.
April 2024: Lancet Global Health
#18
JOURNAL ARTICLE
Mila Shakya, Andrew J Pollard
No abstract text is available yet for this article.
April 2024: Lancet Global Health
#19
JOURNAL ARTICLE
Kun Xiong, Luxin Deng, Zhan Li, Haiyan Gong, Jie Chen, Mintao Huang, Xiancai Rao, Yanguang Cong
Multiple TonB dependent transporters (TBDTs) contribute to bacterial virulence due to the importance roles that their substrates play in bacterial growth, and possess vaccine potential. A putative TBDT, YncD, had been identified as one of in vivo induced antigens during human infection of typhoid fever, and is required for the pathogenicity of Salmonella enterica Serovar Typhi. The present study was aimed to determine the function and immunogenicity of YncD. Homologous recombination method was used to construct an yncD-deletion mutant and cirA-iroN-fepA-deletion mutant from the wild-type S...
March 12, 2024: World Journal of Microbiology & Biotechnology
#20
JOURNAL ARTICLE
Sara Dolatyabi, Sankar Renu, Jennifer Schrock, Gourapura J Renukaradhya
Non-typhoidal Salmonella infection is a significant health and economic burden in poultry industry. Developing an oral vaccine to induce robust mucosal immunity in the intestines of birds, especially cross protection against different Salmonella serotypes is challenging. Therefore, a potent oral vaccine platform that can mitigate different serotypes of Salmonella is warranted for the poultry industry. We reported earlier that the Salmonella enteritidis (SE) immunogenic outer membrane proteins (OMPs) and flagellin (FLA) entrapped in mannose chitosan nanoparticles (OMPs-FLA-mCS NPs) administered prime-boost (d-3 and 3-wk later) by oral inoculation elicits mucosal immunity and reduces challenge SE colonization by over 1 log10 CFU in birds...
February 17, 2024: Poultry Science
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