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https://www.readbyqxmd.com/read/28285420/fosfomycin-and-comparator-activity-against-select-enterobacteriaceae-pseudomonas-and-enterococcus-urinary-tract-infection-isolates-from-the-united-states-in-2012
#1
Tiffany R Keepers, Marcela Gomez, Chris Celeri, Kevin M Krause, Donald Biek, Ian Critchley
INTRODUCTION: Fosfomycin is a broad-spectrum cell wall active agent that inhibits the MurA enzyme involved in peptidoglycan synthesis and is FDA-approved for treatment of uncomplicated urinary tract infections (UTIs) caused by Escherichia coli and Enterococcus faecalis in women. Data regarding the susceptibility of recent UTI isolates to fosfomycin are limited. METHODS: This study compared the fosfomycin susceptibility of 658 US UTI isolates with susceptibility to ciprofloxacin, levofloxacin, nitrofurantoin, and trimethoprim/sulfamethoxazole (SXT)...
March 11, 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/28264656/antimicrobial-susceptibilities-of-aerobic-and-facultative-gram-negative-bacilli-isolated-from-chinese-patients-with-urinary-tract-infections-between-2010-and-2014
#2
Qiwen Yang, Hui Zhang, Yao Wang, Zhipeng Xu, Ge Zhang, Xinxin Chen, Yingchun Xu, Bin Cao, Haishen Kong, Yuxing Ni, Yunsong Yu, Ziyong Sun, Bijie Hu, Wenxiang Huang, Yong Wang, Anhua Wu, Xianju Feng, Kang Liao, Yanping Luo, Zhidong Hu, Yunzhuo Chu, Juan Lu, Jianrong Su, Bingdong Gui, Qiong Duan, Shufang Zhang, Haifeng Shao, Robert E Badal
BACKGROUND: The objective of this study was to investigate the distribution and susceptibility of aerobic and facultative Gram-negative bacilli isolated from Chinese patients with UTIs collected within 48 h (community acquired, CA) or after 48 h (hospital acquired, HA) of hospital admission. METHODS: From 2010 to 2014, the minimum inhibitory concentrations (MICs) of 12 antibiotics for 4,332 aerobic and facultative Gram-negative bacilli, sampled in 21 hospitals in 16 cities, were determined by the broth microdilution method...
March 6, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28193648/pharmacodynamics-of-finafloxacin-ciprofloxacin-and-levofloxacin-in-serum-and-urine-against-tem-and-shv-type-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-isolated-from-patients-with-urinary-tract-infections
#3
A Dalhoff, S Schubert, A Vente
Background: Pharmacodynamics of finafloxacin, ciprofloxacin and levofloxacin against ESBL-producing Enterobacteriaceae were compared. As quinolones loose activity in acidic media and in particular in urine, their activities were tested in parallel under conventional conditions and in acidic artificial urine.Methods: TEM- and SHV-type ESBL-producing E. coli and K. pneumoniae and their wild-type counterparts were exposed in a modified Grasso model to serum- and urine-concentrations following oral doses of finafloxacin 800mg qd, immediate- release ciprofloxacin 500mg bid, extended release ciprofloxacin-XR 1000mg qd, levofloxacin 500mg qd, or levofloxacin 750mg qd...
February 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28187754/extended-spectrum-beta-lactamase-producing-organisms-causing-urinary-tract-infections-in-sri-lanka-and-their-antibiotic-susceptibility-pattern-a-hospital-based-cross-sectional-study
#4
M M P S C Fernando, W A N V Luke, J K N D Miththinda, R D S S Wickramasinghe, B S Sebastiampillai, M P M L Gunathilake, F H D S Silva, R Premaratna
BACKGROUND: Extended Spectrum Beta- Lactamase producing organisms causing urinary tract infections (ESBL-UTI) are increasing in incidence and pose a major burden to health care. While ESBL producing Klebsiella species seem to account for most nosocomial outbreaks, ESBL-producing E. coli have been isolated from both hospitalized and non-hospitalized patients. Although 95-100% ESBL organisms are still considered sensitive to meropenem, rapid emergence of carbapenem resistance has been documented in many countries...
February 10, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28182124/extended-spectrum-beta-lactamase-and-carbapenemase-producing-enterobacteriaceae-among-ethiopian-children
#5
Melese Hailu Legese, Gebru Mulugeta Weldearegay, Daniel Asrat
BACKGROUND: Infections by extended-spectrum beta-lactamase- (ESBL) and carbapenem-resistant Enterobacteriaceae (CRE) are an emerging problem in children nowadays. Hence, the aim of this study was to determine the prevalence of ESBL- and carbapenemase-producing Enterobacteriaceae among children suspected of septicemia and urinary tract infections (UTIs). METHODS: A cross-sectional study was conducted from January to March 2014. A total of 322 study participants suspected of septicemia and UTIs were recruited...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28167307/fosfomycin-in-vitro-efficacy-against-multidrug-resistant-isolates-beyond-urinary-isolates
#6
Tulin Demir, Tuncay Buyukguclu
OBJECTIVES: Fosfomycin (FOF) is a bactericidal antimicrobial agent active against a range of Gram-negative bacteria, including multidrug-resistant (MDR) and metallo-β-lactamase (MBL)-producing Enterobacteriaceae. However, data are scarce regarding use of the drug beyond urinary tract infections (UTIs). METHODS: In this study, susceptibility rates to FOF among 290 MDR Enterobacteriaceae isolates were analysed by gradient and disk diffusion tests and the results were compared with agar dilution according to the Clinical and Laboratory Standards Institute (CLSI)...
February 3, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28154560/detection-of-sgi1-pgi1-elements-and-resistance-to-extended-spectrum-cephalosporins-in-proteae-of-animal-origin-in-france
#7
Eliette Schultz, Axel Cloeckaert, Benoît Doublet, Jean-Yves Madec, Marisa Haenni
Proteae, and especially Proteus mirabilis, are often the cause of urinary tract infections (UTIs) in humans. They were reported as carriers of extended-spectrum β-lactamase (ESBL) genes, and recently of carbapenemases, mostly carried by the Salmonella genomic island 1 (SGI1) and Proteus genomic island 1 (PGI1). Proteae have also lately become an increasing cause of UTIs in companion animals, but antimicrobial susceptibility data in animals are still scarce. Here, we report the characterization of 468 clinical epidemiologically unrelated Proteae strains from animals collected between 2013 and 2015 in France...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28146187/-factors-associated-with-extended-spectrum-betalactamases-producing-organisms-among-patients-with-urinary-tract-infections-a-prospective-cohort-study
#8
Cristián Avilés, Pablo Betancour, Carmen Luz Velasco, Rodrigo Godoy, Elizabeth Barthel, Felipe Martínez
BACKGROUND: Urinary tract infections (UTIs) caused by extended-spectrum betalactamases (ESBL) are an increasingly common problem. AIM: To develop an association model to allow an early detection of ESBL-producing microorganisms. METHODS: A prospective observational cohort study was undertaken among patients admitted with a diagnosis of culture-proven UTI to the Internal Medicine Ward of the Hospital Naval Almirante Nef between February and November, 2011...
December 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28131557/-profile-of-bacterial-resistance-in-pediatric-urinary-tract-infections-in-2014
#9
A Flammang, R Morello, M Vergnaud, J Brouard, P Eckart
In pediatric units, bacteria-producing extended-spectrum-betalactamase (ESBL) have an increasing prevalence among bacteria causing febrile urinary tract infections (UTIs). The purpose of this study was to evaluate the epidemiology of bacteria resistance patterns observed in UTIs, in order to assess the current antibiotic treatment protocols. This study is based upon a single-center retrospective chart review of the cytobacteriological urine cultures performed in UTIs between 1 January and 31 December 2014, in the medical pediatric unit of the Caen University Hospital...
January 25, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28122913/epidemiology-and-susceptibility-of-pathogens-from-smart-2011-12-turkey-evaluation-of-hospital-acquired-versus-community-acquired-urinary-tract-infections-and-icu-versus-non-icu-associated-intra-abdominal-infections
#10
Iftihar Koksal, Gurdal Yilmaz, Serhat Unal, Pinar Zarakolu, Volkan Korten, Lutfiye Mulazimoglu, Fehmi Tabak, Birgul Mete, Vildan Avkan Oguz, Zeynep Gulay, Emine Alp, Robert Badal, Sibylle Lob
OBJECTIVES: To describe the epidemiology and susceptibility of pathogens (including ESBL producers) from hospital-acquired (HA) versus community-acquired (CA) urinary tract infections (UTIs) and ICU- versus non-ICU-associated intra-abdominal infections (IAIs) in Turkey as a part of the SMART study. METHODS: For this report, Gram-negative pathogens (363 from UTIs and 458 from IAIs) were collected in 2011 and 2012 at six hospitals in Turkey. HA versus CA UTIs and ICU- versus non-ICU-associated IAIs were compared for the species isolated, percentage of ESBL-positive isolates by species and susceptibility for overall and individual Gram-negative species...
January 25, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28096977/high-rates-of-multidrug-resistance-among-uropathogenic-escherichia-coli-in-children-and-analyses-of-esbl-producers-from-nepal
#11
Narayan Prasad Parajuli, Pooja Maharjan, Hridaya Parajuli, Govardhan Joshi, Deliya Paudel, Sujan Sayami, Puspa Raj Khanal
BACKGROUND: Emergence of Extended-spectrum beta-lactamase producing Escherichia coli causing urinary tract infections (UTI) among pediatric patients is an increasing problem worldwide. However, very little is known about pediatric urinary tract infections and antimicrobial resistance trend from Nepal. This study was conducted to assess the current antibiotic resistance rate and ESBL production among uropathogenic Escherichia coli in pediatric patients of a tertiary care teaching hospital of Nepal...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28054236/antibiotic-resistance-patterns-of-escherichia-coli-urinary-isolates-and-comparison-with-antibiotic-consumption-data-over-10%C3%A2-years-2005-2014
#12
P J Stapleton, D J Lundon, R McWade, N Scanlon, M M Hannan, F O'Kelly, M Lynch
INTRODUCTION: Escherichia coli is a common cause of urinary tract infections (UTI). Reviews of antibiotic resistance of this organism can inform choice of empiric treatment of UTI and other infections and strategies for combating antimicrobial resistance. We reviewed laboratory and hospital pharmacy records to assess trends in non-susceptibility rates and the effect of antimicrobial stewardship interventions. METHODS: A retrospective observational study of isolates of E...
January 4, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28051952/antimicrobial-susceptibility-of-gram-negative-eskape-pathogens-isolated-from-hospitalized-patients-with-intra-abdominal-and-urinary-tract-infections-in-asia-pacific-countries-smart-2013-2015
#13
James A Karlowsky, Daryl J Hoban, Meredith A Hackel, Sibylle H Lob, Daniel F Sahm
Gram-negative ESKAPE pathogens (Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.) are responsible for increases in antimicrobial-resistant infections worldwide. We determined in vitro susceptibilities to eight parenteral antimicrobial agents using Clinical and Laboratory Standards Institute broth microdilution methodology for Gram-negative ESKAPE pathogens isolated from hospitalized patients with intra-abdominal infections (IAIs) (n=3052) and urinary tract infections (UTIs) (n=1088) in 11 Asia-Pacific countries/regions from 2013 to 2015...
January 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28028717/multi-drug-resistant-uropathogenic-escherichia-coli-and-its-treatment-by-chinese-medicine
#14
Shi-Wei Liu, Xiao-Yang Xu, Jie Xu, Jiu-Yun Yuan, Wei-Kang Wu, Ning Zhang, Ze-Liang Chen
OBJECTIVES: To investigate the resistance and virulence profiles of uropathogenic Escherichia coli (UPEC) and its treatment by Chinese medicine (CM) Fuzheng Qingre Lishi Formula (, FQLF). METHODS: UPEC strains were isolated from recurrent urinary tract infections (UTIs) patients. Patient sensitivities to 17 antibiotics were tested by the disk diffusion method. Virulence genes were screened by plolymerase chain reaction. A mouse model was constructed using a multi-drug resistant and virulent UPEC strain and treated with FQLF or the antibiotic imipenem...
December 27, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28011969/comparison-of-quinolone-and-beta-lactam-resistance-among-escherichia-coli-strains-isolated-from-urinary-tract-infections
#15
Zahra Tayebi, Hamid Heidari, Hossein Kazemian, Seyed Mohammad Ghafoori, Shahram Boroumandi, Hamidreza Houri
The growing frequency of antibiotic resistances is now a universal problem. Increasing resistance to new generations of β-lactam and quinolone antibiotics in multidrug-resistant Enterobacteriaceae isolates is considered an emergency health issue worldwide. The aim of this study was to evaluate plasmid-mediated quinolone resistance genes in ESBL-producing Escherichia coli isolated from urinary tract infections (UTIs). In our study ESBL-producing isolates were assessed by screening methods. After determination of antimicrobial susceptibility testing, detection of ESBLs and quinolone resistance genes was performed...
December 1, 2016: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/27986743/treatment-of-febrile-geriatric-patients-with-suspected-urinary-tract-infections-in-a-hospital-with-high-rates-of-esbl-producing-bacteria-a-cohort-study
#16
Zvi Shimoni, Regev Cohen, Ruslan Avdiaev, Paul Froom
PURPOSE: To determine the consequences of treating febrile geriatric patients with a suspected urinary tract infection (UTI) with antibiotics that have high resistance rates due primarily to extended-spectrum β-lactamase (ESBL) producing bacteria. METHODS: In this cohort study, we selected 257 consecutive hospitalised patients aged ≥70 years with a chief symptom of fever, possibly due to a UTI and initially treated with antibiotics with rates in our hospital of urinary culture resistance >20%...
December 16, 2016: BMJ Open
https://www.readbyqxmd.com/read/27979787/worrisome-high-frequency-of-extended-spectrum-beta-lactamase-producing-escherichia-coli-in-community-acquired-urinary-tract-infections-a-case-control-study
#17
Franco Castillo-Tokumori, Claudia Irey-Salgado, Germán Málaga
OBJECTIVES: There has been a sustained and dramatic increase in community-acquired urinary tract infections (CA-UTI) caused by extended-spectrum beta-lactamase (ESBL)-producing bacteria over recent years. Despite this, no studies have been performed in low- or middle-income countries. The main objective of this case-control study was to describe ESBL CA-UTI and its risk factors. METHODS: Outpatients with CA-UTI seen at the Hospital Cayetano Heredia during 2015 were identified...
December 12, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27942843/common-findings-of-bla-ctx-m-55-encoding-104-139-kbp-plasmids-harbored-by-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-in-pork-meat-wholesale-market-workers-and-patients-with-urinary-tract-infection-in-vietnam
#18
T A V Hoang, T N H Nguyen, S Ueda, Q P Le, T T N Tran, T N D Nguyen, T V K Dao, M T Tran, T T T Le, T L Le, T Nakayama, I Hirai, T H Do, Q M Vien, Y Yamamoto
Extended-spectrum, β-lactamase-producing Escherichia coli (ESBL-E) harboring the bla CTX-M-55-encoding plasmid (ESBL-E55) has been reported to be associated with urinary tract infection (UTI). The aims of this study were to clarify the prevalence of ESBL-E55 in pork meats and workers from the same wholesale market, as well as patients with UTI from a nearby hospital in Vietnam; we also investigated the plasmids encoding bla CTX-M-55. Sequencing analysis showed that 66.6% of the ESBL-E isolated from pork meats contained bla CTX-M-55, whereas the gene was present in 25...
February 2017: Current Microbiology
https://www.readbyqxmd.com/read/27902433/escherichia-coli-clonal-group-a-among-uropathogenic-infections-in-mexico-city
#19
Angel Manjarrez-Hernandez, José Molina-López, Sandra Gavilanes-Parra, Rigoberto Hernandez-Castro
Escherichia coli clonal group A (CGA) causes urinary tract and other extra-intestinal infections in humans. CGA is an important cause of trimethoprim/sulfamethoxazole (SXT) resistance in extra-intestinal pathogens. We examined the extent to which resistance in this area is related to CGA dissemination of E. coli from urinary tract infections (UTIs) in Mexico City. The virulence backgrounds of the isolates were also characterized. In this study, the frequency of resistance to SXT used for UTI treatment was high (56-65 %), and CGA isolates accounted for 9 of the 78 SXT-resistant isolates (11...
December 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27894763/extended-spectrum-beta-lactamase-esbl-producing-bacteria-urinary-tract-infections-and-complex-pediatric-urology
#20
Ruth Wragg, Anna Harris, Mitul Patel, Andrew Robb, Harish Chandran, Liam McCarthy
AIM OF THE STUDY: Extended spectrum beta lactamase (ESBL) producing bacteria are resistant to most beta-lactam antibiotics including third-generation cephalosporins, quinolones and aminoglycosides. This resistance is plasmid-borne and can spread between species. Management of ESBL is challenging in children with recurrent urinary tract infections (UTIs) and complex urological abnormalities. We aim to quantify the risk in children and specifically in urological patients. METHODS: Retrospective review of a microbiology database (April 2014 to November 2015)...
February 2017: Journal of Pediatric Surgery
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