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https://www.readbyqxmd.com/read/29778819/detection-of-tem-and-ctx-m-genes-from-ciprofloxacin-resistant-proteus-mirabilis-and-escherichia-coli-isolated-on-urinary-tract-infections-utis
#1
Govindan Rajivgandhi, Muthuchamy Maruthupandy, Natesan Manoharan
The multidrug resistant Gram negative bacteria (MDRGNB) is an emerging burden and now represents a daily challenge for the management of antimicrobial therapy in healthcare settings. The present study was aimed to detect the prevalence of TEM and CTX-M type genes from GNB on urinary tract infection (UTIs). The ciprofloxacin resistant uropathogens were detected by HEXA UTI 5 disc diffusion method. The phenotypic detection of uropathogens producing extended spectrum beta lactamases (ESBLs) was confirmed by double disc combination (DDCT) and phenotype confirmation methods (PCT)...
May 17, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29775789/e-coli-encoding-blandm-5-associated-with-community-acquired-uti-cases-with-unusual-mic-creep-like-phenomenon-against-imipenem
#2
Varsha Rani Gajamer, Amitabha Bhattacharjee, Deepjyoti Paul, Chandrayee Deshamukhya, Ashish Kr Singh, Nilu Pradhan, Hare Krishna Tiwari
OBJECTIVES: Carbapenemase-producing Escherichia coli are of major clinical concern. The present study aimed to identify NDM-5 producing E.coli associated with community-acquired urinary tract infection, co-harboring ESBL genes and a pattern of imipenem MIC creep. METHODS: A total of 973 urine samples were collected from females of age between 18-49 diagnosed with UTI. Isolates were identified by standard microbiological procedures. Presence of blaNDM and ESBL genes was determined by PCR assay and sequencing...
May 15, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29754209/activity-of-ertapenem-against-enterobacteriaceae-in-seven-global-regions-smart-2012-2016
#3
Sibylle H Lob, Meredith A Hackel, Daryl J Hoban, Katherine Young, Mary R Motyl, Daniel F Sahm
Antimicrobial resistance among Enterobacteriaceae has been increasing globally especially due to extended-spectrum-β-lactamases (ESBLs), which typically necessitate the use of carbapenems for treatment of serious infections. Emerging carbapenem-resistant Enterobacteriaceae further complicate therapy. As part of the Study for Monitoring Antimicrobial Resistance Trends (SMART), this analysis examined the recent activity of a key carbapenem (ertapenem) and other important therapeutic options against Enterobacteriaceae...
May 12, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29748840/clinical-patterns-epidemiology-and-risk-factors-of-community-acquired-urinary-tract-infection-caused-by-extended-spectrum-beta-lactamase-producers-a-prospective-hospital-case-control-study
#4
Basima A Almomani, Wail A Hayajneh, Abeer M Ayoub, Mera A Ababneh, Miral A Al Momani
PURPOSE: To assess incidence rate, risk factors and susceptibility patterns associated with extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli or Klebsiella pneumoniae in community-acquired urinary tract infections (CA-UTIs). METHODS: A prospective, case-control study was conducted at a tertiary teaching hospital from Jan 2015 to Dec 2016. The results of microbiology cultures were initially screened to include only patients with positive E. coli or K...
May 10, 2018: Infection
https://www.readbyqxmd.com/read/29659836/efficacy-and-safety-of-ceftazidime-avibactam-a-systematic-review-and-meta-analysis
#5
Neta Sternbach, Yaara Leibovici Weissman, Tomer Avni, Dafna Yahav
Background: Ceftazidime/avibactam is approved for complicated intra-abdominal and urinary tract infections (UTIs) based on results from randomized controlled trials (RCTs). Data regarding its effectiveness in treating hospital-acquired infections or resistant pathogens have not been systematically compiled. Methods: A systematic review and meta-analysis including RCTs evaluating ceftazidime/avibactam versus comparator for the treatment of any infection. Primary outcome was 30 day all-cause mortality...
April 6, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29652969/-molecular-characterization-and-antimicrobial-susceptibility-pattern-of-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-as-cause-of-community-acquired-urinary-tract-infection
#6
Mario Galindo-Méndez
Background Community acquired urinary tract infections (CaUTI) caused by strains of extended-spectrum β-lactamases (ESBL) - producing Escherichia coli, mainly by strains carrying the blaCTX-M-15 gene, is a growing phenomenon worldwide. Aim To determine the antibiotic susceptibility pattern of ESBL-producing E. coli as cause of CaUTI and to identify their molecular pattern. Methods A descriptive study was performed in the city of Oaxaca, Mexico, from where 288 strains of CaUTI-producing strains of E. coli in adults with possible UTI were isolated...
2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29594799/managing-esbl-producing-enterobacteriaceae-related-urinary-tract-infection-in-primary-care-a-tool-kit-for-general-practitioners
#7
Aurélie Zucconi, Johan Courjon, Christophe Maruéjouls, Fabrice Saintpère, Nicolas Degand, Lilli Pandiani, Christian Pradier, Véronique Mondain
In Southern France, approximately 4% of E. coli isolates from community-acquired urinary tract infections are extended spectrum beta-lactamase producers, while carriage rates for enterobacteriaceae (ESBL-E) range from 3 to 6%. General practitioners (GP) are unfamiliar with the management of patients harboring ESBL-E. Providing them with a specific tool kit should assist in their therapeutic approach and optimize antimicrobial prescription an ESBL-E tool kit was developed by a multidisciplinary team: infectious diseases (ID) specialists, microbiologists, pharmacologists, and nursing home staff...
May 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29581117/pharmacokinetics-and-pharmacodynamics-of-fosfomycin-and-its-activity-against-esbl-plasmid-mediated-ampc-and-carbapenemase-producing-escherichia-coli-in-a-murine-urinary-tract-infection-model
#8
Ilya Nikolaevich Zykov, Ørjan Samuelsen, Lotte Jakobsen, Lars Småbrekke, Dan I Andersson, Arnfinn Sundsfjord, Niels Frimodt-Møller
Fosfomycin has become an attractive treatment alternative for urinary tract infections (UTIs) due to increasing multidrug-resistance (MDR) in Escherichia coli In this study, we evaluated the pharmacokinetic and pharmacodynamic (PK/PD) indices of fosfomycin and its in vivo activity in an experimental murine model of ascending UTI. Subcutaneous administration of fosfomycin showed that the mean peak plasma concentrations of fosfomycin were 36, 280, and 750 mg/L following administration of a single dose of 0.75, 7...
March 26, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29581074/susceptibility-profiles-of-bacteria-causing-urinary-tract-infection-in-mexico-single-center-experience-with-10-years-results
#9
Francisco Alejandro Lagunas-Rangel
OBJECTIVES: The aim of this retrospective study was to describe urinary tract infections (UTIs) diagnosed in a single center in Mexico through 10 years of results, with a particular emphasis on the etiology, patterns of antimicrobial susceptibility and incidence of extended-spectrum β-lactamase-producing strains (ESBL). METHODS: This study involved all urine samples analyzed during the period between March 2007 and September 2017. Isolated uropathogens were identified to species level using routine laboratory methods Antimicrobial susceptibility was determined by the disc diffusion method...
March 23, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29571839/activity-of-omadacycline-tested-against-enterobacteriaceae-causing-urinary-tract-infections-from-a-global-surveillance-program-2014
#10
M A Pfaller, P R Rhomberg, M D Huband, R K Flamm
Omadacycline is an aminomethylcycline with in vitro activity against many gram-negative pathogens. Omadacycline and comparators were tested against Enterobacteriaceae from urinary tract infections (UTIs) selected from a 2014 global surveillance program and compared to results of isolates from 2010 surveillance. The omadacycline MIC50/90 for Enterobacteriaceae collected during 2014 was 2/≥8 μg/mL (1/4 μg/mL minus Proteus, Providencia, and Morganella spp.). The MIC50/90 for E. coli was 1/2 μg/mL, similar to that in 2010 (MIC50/90 , 0...
February 24, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29563719/nitrofurantoin-and-fosfomycin-for-extended-spectrum-beta-lactamases-producing-escherichia-coli-and-klebsiella-pneumoniae
#11
Neeraj Kumar Tulara
Urinary tract infection (UTI) is a common and painful human illness that, unfortunately not responsive to commonly used antibiotics in current practice. The role of fosfomycin and nitrofurantoin in the era of growing bacteria resistance has been widely discussed. In this study, we aimed to know the local antimicrobial susceptibilities, fosfomycin and nitrofurantoin susceptibility in particular, for urinary extended-spectrum-beta-lactamase-producing Escherichia coli and Escherichia pneumoniae (ESBL-EC and ESBL-KP) isolates in our hospital...
January 2018: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29557289/susceptibility-of-escherichia-coli-to-nitroxoline-an-option-for-uncomplicated-urinary-tract-infections-the-first-report-from-croatia
#12
Ivana Mareković, Zrinka Bošnjak, Karla Jurić, Mario Ćorić, Sanja Popović-Grle
Nitroxoline (NTX), 5-nitro-8-hydroxyquinoline is an oral antibiotic with mechanism of bacteriostatic activity that is based on chelation of divalent cations required for bacterial RNA polymerase. Susceptibility to NTX of 100 Escherichia coli urine isolates was determined at the Department of Clinical and Molecular Microbiology, University Hospital Centre Zagreb during September and October 2017. Antimicrobial susceptibility was tested by disc diffusion and the results were interpreted according to the European Committee for Antimicrobial Susceptibility Testing (EUCAST) standards...
May 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29534774/outcomes-of-uti-and-bacteriuria-caused-by-esbl-vs-non-esbl-enterobacteriaceae-isolates-in-pregnancy-a-matched-case-control-study
#13
Y Yagel, H Nativ, K Riesenberg, L Nesher, L Saidel-Odes, R Smolyakov
Infections caused by extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) have become increasingly prevalent, posing a serious public threat worldwide. It is commonly believed that untreated urinary tract infections (UTI) and asymptomatic bacteriuria (ABU) during pregnancy are associated with poor obstetric outcomes. Currently, there is a paucity of data regarding the outcomes or risk factors of such ESBL-E infections in pregnant women. We conducted a retrospective 1:2 matched case-control study of hospitalised pregnant women with ESBL-E- vs...
April 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29521484/impact-of-an-antimicrobial-stewardship-program-on-urinary-tract-infections-caused-by-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli
#14
E Esteve-Palau, S Grau, S Herrera, L Sorlí, M Montero, C Segura, X Durán, J P Horcajada
OBJECTIVE: To analyze the clinical and economic impact of an antimicrobial stewardship program (ASP) targeting urinary tract infections (UTI) caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli. METHODS: An observational retrospective study that included adults with a diagnosis of UTI caused by ESBL-producing E. coli admitted to a tertiary care hospital in Barcelona, Spain, between January 2014 and December 2015. The impact of the ASP was analyzed in terms of clinical and economic outcomes...
April 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29519530/antimicrobial-resistance-multilocus-sequence-types-and-virulence-profiles-of-esbl-producing-and-non-esbl-producing-uropathogenic-escherichia-coli-isolated-from-cats-and-dogs-in-switzerland
#15
Anna Lena Zogg, Katrin Zurfluh, Sarah Schmitt, Magdalena Nüesch-Inderbinen, Roger Stephan
Among 64 uropathogenic Escherichia coli (UPEC) isolated from 13 cats and 51 dogs, 35 were extended-spectrum beta-lactamase (ESBL) producers, and 29 were non-ESBL producers. Forty-six (71.9%) of the isolates were multidrug resistant (MDR). Among the ESBL producers, blaCTX-M-15 (n = 17/48.6% of the blaESBLs ), blaCTX-M-1 (n = 10/28.6%), blaCTX-M-55 (n = 4/11.4%), blaCTX-M-14 (n = 3/8.6%), and blaCTX-M-27 (n = 1/2.9%) were identified. The plasmid-mediated fluoroquinolone resistance genes aac(6')-Ib-cr, qnrB and the azithromycin resistance gene mph(A) were detected in 17 (26...
March 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29513841/clonal-relationships-antimicrobial-susceptibilities-and-molecular-characterization-of-extended-spectrum-beta-lactamase-producing-escherichia-coli-isolates-from-urinary-tract-infections-and-fecal-samples-in-southeast-iran
#16
Zahra Hashemizadeh, Davood Kalantar-Neyestanaki, Shahla Mansouri
INTRODUCTION: Multidrug-resistant (MDR) Escherichia coli, a species that is a leading cause of urinary tract infections (UTIs) and is a major global public health concern. This study was designed to detect the differences in antibiotic resistance patterns, the production and type of extended spectrum β-lactamases (ESBLs), and the clonal relationships among E. coli isolates from UTIs and fecal samples. METHODS: Antibacterial resistance was determined by the disk diffusion method...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29503639/comprehensive-molecular-characterization-of-escherichia-coli-isolates-from-urine-samples-of-hospitalized-patients-in-rio-de-janeiro-brazil
#17
Ana Carolina C Campos, Nathália L Andrade, Mithila Ferdous, Monika A Chlebowicz, Carla C Santos, Julio C D Correal, Jerome R Lo Ten Foe, Ana Cláudia P Rosa, Paulo V Damasco, Alex W Friedrich, John W A Rossen
Urinary tract infections (UTIs) are often caused by Escherichia coli . Their increasing resistance to broad-spectrum antibiotics challenges the treatment of UTIs. Whereas, E. coli ST131 is often multidrug resistant (MDR), ST69 remains susceptible to antibiotics such as cephalosporins. Both STs are commonly linked to community and nosocomial infections. E. coli phylogenetic groups B2 and D are associated with virulence and resistance profiles making them more pathogenic. Little is known about the population structure of E...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29449049/extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-national-study-of-antimicrobial-treatment-for-pediatric-urinary-tract-infection
#18
M Lagree, S Bontemps, R Dessein, F Angoulvant, F Madhi, A Martinot, R Cohen, F Dubos
OBJECTIVE: To evaluate clinical practices for ESBL-producing urinary tract infection (UTI) in France. METHODS: We performed an observational, retrospective, cross-sectional, hospital-based study in 22 pediatric departments of university or secondary care hospitals. We collected data of the last five patients presenting with ESBL-producing UTI in 2012 and the physicians' therapeutic approach to two case vignettes of acute non-septic ESBL-producing pyelonephritis (7-month-old girl) and cystitis (30-month-old girl)...
May 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29409967/community-acquired-urinary-tract-infections-due-to-extended-spectrum-%C3%AE-lactamase-producing-organisms-in-united-arab-emirates
#19
Nihar Ranjan Dash, Mohammad T Albataineh, Nawar Alhourani, Ammar Mohammad Khoudeir, Mohammed Ghanim, Mohammad Wasim, Ibrahim Mahmoud
BACKGROUND: The epidemiology of extended-spectrum β-lactamase (ESBL)-producing bacteria is fast evolving with increasing global trend towards community-acquired infections. Limited information available about ESBLs therapy outcomes and control strategies, especially in the Middle Eastern countries. METHODS: We studied 399 ESBL-producing Escherichia coli and Klebsiella pneumoniae isolates from urinary tract infections (UTIs) occurred between 2014 and 2016 in University Hospital Sharjah...
January 31, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29382515/clinical-characterization-and-antimicrobial-resistance-of-escherichia-coli-in-pediatric-patients-with-urinary-tract-infection-at-a-third-level-hospital-of-quito-ecuador
#20
David Garrido, Santiago Garrido, Miguel Gutiérrez, Leonel Calvopiña, Amani Sunday Harrison, Michelle Fuseau, Ramiro Salazar Irigoyen
BACKGROUND: Urinary tract infections (UTI) are among the most common infections in pediatric patients. The main etiopathogenic agent is Escherichia coli. The purpose of this study was to determine the antimicrobial resistance pattern of E. coli in pediatric patients and to understand their main clinical and laboratory manifestations. METHODS: Fifty-nine patients were included in the study and classified into two groups: hospitalization (H) and external consultation (EC)...
July 2017: Boletín Médico del Hospital Infantil de México
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