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https://www.readbyqxmd.com/read/29684936/the-relationship-between-hard-tissue-and-soft-tissue-dimensions-of-the-nose-in-children-a-3d-cone-beam-computed-tomography-study
#1
Eman Allam, Philani Mpofu, Ahmed Ghoneima, Mihran Tuceryan, Katherine Kula
This study using three-dimensional cone beam computed tomography (CBCT) images of children determined relationships between nasal skeletal and soft tissue measurements and assessed the association with sex, age, and skeletal maturation stage. Following reliability studies, skeletal and soft tissue parameters were measured on coded CBCTs of 73 children (28M:45F;6-13 yoa). Pearson and Mantel correlations were used to analyze associations between skeletal and soft tissues. Partial Mantel correlations were used to study the associations between skeletal and soft tissue, adjusting for sex, age, and skeletal maturation...
April 23, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29684787/the-body-electric-2-0-recent-advances-in-developmental-bioelectricity-for-regenerative-and-synthetic-bioengineering
#2
REVIEW
Juanita Mathews, Michael Levin
Breakthroughs in biomedicine and synthetic bioengineering require predictive, rational control over anatomical structure and function. Recent successes in manipulating cellular and molecular hardware have not been matched by progress in understanding the patterning software implemented during embryogenesis and regeneration. A fundamental capability gap is driving desired changes in growth and form to address birth defects and traumatic injury. Here we review new tools, results, and conceptual advances in an exciting emerging field: endogenous non-neural bioelectric signaling, which enables cellular collectives to make global decisions and implement large-scale pattern homeostasis...
April 20, 2018: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/29684484/characterization-of-long-non-coding-rnas-to-reveal-potential-prognostic-biomarkers-in-hepatocellular-carcinoma
#3
REVIEW
Yijie Ma, Tong Luo, Dong Dong, Xubo Wu, Yilin Wang
Dysregulation of long non-coding RNAs (lncRNAs) plays critical roles in a variety of biological processes. Recent studies have documented that lncRNAs can function as potential biomarkers in cancer prognosis, however, little is known in hepatocellular carcinoma (HCC). To identify lncRNA signatures that have prognostic values in HCC, we analyzed lncRNA expression profiles of 364 HCC patients from The Cancer Genome Atlas (TCGA) dataset. A set of four lncRNAs was identified to be significantly associated with the overall survival...
April 20, 2018: Gene
https://www.readbyqxmd.com/read/29683920/the-problem-with-magnitude-based-inference
#4
Kristin L Sainani
PURPOSE: A statistical method called "Magnitude-Based Inference" (MBI) has gained a following in the sports science literature, despite concerns voiced by statisticians. Its proponents have claimed that MBI exhibits superior Type I and Type II error rates compared with standard null hypothesis testing for most cases. I have performed a re-analysis to evaluate this claim. METHODS: Using simulation code provided by MBI's proponents, I estimated Type I and Type II error rates for clinical and non-clinical MBI for a range of effect sizes, sample sizes, and smallest important effects...
April 21, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29683518/the-function-and-failure-of-sensory-predictions
#5
REVIEW
Sonia Bansal, Judith M Ford, Miriam Spering
Humans and other primates are equipped with neural mechanisms that allow them to automatically make predictions about future events, facilitating processing of expected sensations and actions. Prediction-driven control and monitoring of perceptual and motor acts are vital to normal cognitive functioning. This review provides an overview of corollary discharge mechanisms involved in predictions across sensory modalities and discusses consequences of predictive coding for cognition and behavior. Converging evidence now links impairments in corollary discharge mechanisms to neuropsychiatric symptoms such as hallucinations and delusions...
April 23, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29683495/now-you-hear-it-a-predictive-coding-model-for-understanding-rhythmic-incongruity
#6
Peter Vuust, Martin J Dietz, Maria Witek, Morten L Kringelbach
Rhythmic incongruity in the form of syncopation is a prominent feature of many contemporary musical styles. Syncopations afford incongruity between rhythmic patterns and the meter, giving rise to mental models of differently accented isochronous beats. Syncopations occur either in isolation or as part of rhythmic patterns, so-called grooves. On the basis of the predictive coding framework, we discuss how brain processing of rhythm can be seen as a special case of predictive coding. We present a simple, yet powerful model for how the brain processes rhythmic incongruity: the model for predictive coding of rhythmic incongruity...
April 23, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29682276/characterization-and-potential-role-of-microrna-in-the-chinese-dominant-malaria-mosquito-anopheles-sinensis-diptera-culicidae-throughout-four-different-life-stages
#7
Xinyu Feng, Jiatong Wu, Shuisen Zhou, Jingwen Wang, Wei Hu
Background: microRNAs (miRNAs) are one kind of small non-coding RNAs widely distributed in insects. Many studies have shown that miRNAs play critical roles in development, differentiation, apoptosis, and innate immunity. However, there are a few reports describing miRNAs in Anopheles sinensis , the most common, and one of the dominant malaria mosquito in China. Here, we investigated the global miRNA expression profile across four different developmental stages including embryo, larval, pupal, and adult stages using Illumina Hiseq 2500 sequencing...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29682167/draft-genome-sequence-of-bosea-sp-wao-an-arsenite-and-sulfide-oxidizer-isolated-from-a-pyrite-rock-outcrop-in-new-jersey
#8
Alexandra B Walczak, Nathan Yee, Lily Y Young
This genome report describes the draft genome and physiological characteristics of Bosea sp. WAO (=DSM 102914), a novel strain of the genus Bosea in the family Bradyrhizobiaceae . Bosea sp. WAO was isolated from pulverized pyritic shale containing elevated levels of arsenic. This aerobic, gram negative microorganism is capable of facultative chemolithoautotrophic growth under aerobic conditions by oxidizing the electron donors arsenite, elemental sulfur, thiosulfate, polysulfide, and amorphous sulfur. The draft genome is of a single circular chromosome 6,125,776 bp long consisting of 21 scaffolds with a G + C content of 66...
2018: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/29681614/prevalence-and-spectrum-of-brca1-2-germline-mutations-in-women-with-breast-cancer-in-china-based-on-next-generation-sequencing
#9
Yi Liang, Xuexi Yang, Hong Li, Anna Zhu, Zhiwei Guo, Ming Li
BACKGROUND BRCA1 and BRCA2 (BRCA1/2) play important roles in the development of breast cancer, but information regarding BRCA1/2 mutations in Chinese females remains limited. The aim of this study was to investigate the prevalence and spectrum of BRCA1/2 mutations in China. MATERIAL AND METHODS In total, 595 breast cancer patients in China were screened with an amplicon-based panel for the detection of BRCA1/2 mutations in coding regions using next-generation sequencing (NGS) with a Personal Genome Machine...
April 23, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29681336/response-expectancy-and-the-placebo-effect
#10
Irving Kirsch
In this chapter, I review basic tenets of response expectancy theory (Kirsch, 1985), beginning with the important distinction between response expectancies and stimulus expectancies. Although both can affect experience, the effects of response expectancies are stronger and more resistant to extinction than those of stimulus expectancies. Further, response expectancies are especially important to understanding placebo effects. The response expectancy framework is consistent with and has been amplified by the Bayesian model of predictive coding...
2018: International Review of Neurobiology
https://www.readbyqxmd.com/read/29681325/what-is-minimally-required-to-elicit-placebo-effects
#11
Karin B Jensen
Placebo effects have often been attributed to cognitive processes described as "learning" and/or "expectancy," yet the role of conscious awareness is unclear. Furthermore, little is known about the placebo effects in patients with limited cognitive abilities, such as intellectual disability. Here, recent data on placebo mechanisms in patients with impaired cognitive function will be discussed, as well as experimental studies investigating how implicit cognitive processes may shape placebo effects...
2018: International Review of Neurobiology
https://www.readbyqxmd.com/read/29680449/modeling-tumor-growth-inhibition-and-toxicity-outcome-after-administration-of-anticancer-agents-in-xenograft-mice-a-dynamic-energy-budget-deb-approach
#12
N Terranova, E M Tosca, E Borella, E Pesenti, M Rocchetti, P Magni
Host features, such as cell proliferation rates, caloric intake, metabolism and energetic conditions, significantly influence tumor growth; at the same time, tumor growth may have a dramatic impact on the host conditions. For example, in clinics, at certain stages of the tumor growth, cachexia (body weight reduction) may become so relevant to be considered as responsible for around 20% of cancer deaths. Unfortunately, anticancer therapies may also contribute to the development of cachexia due to reduced food intake (anorexia), commonly observed during the treatment periods...
April 19, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29679745/integrated-genomic-and-metabolomic-profiling-of-isc1-an-emerging-leishmania-donovani-population-in-the-indian-subcontinent
#13
Bart Cuypers, Maya Berg, Hideo Imamura, Franck Dumetz, Géraldine De Muylder, Malgorzata A Domagalska, Suman Rijal, Narayan Raj Bhattarai, Ilse Maes, Mandy Sanders, James A Cotton, Pieter Meysman, Kris Laukens, Jean-Claude Dujardin
Leishmania donovani is the responsible agent for visceral leishmaniasis (VL) in the Indian subcontinent (ISC). The disease is lethal without treatment and causes 0.2 to 0.4 million cases each year. Recently, reports of VL in Nepalese hilly districts have increased as well as VL cases caused by L. donovani from the ISC1 genetic group, a new and emerging genotype. In this study, we perform for the first time an integrated, untargeted genomics and metabolomics approach to characterize ISC1, in comparison with the Core Group (CG), main population that drove the last outbreak of VL in the ISC...
April 18, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29679573/circrna-expression-analysis-in-lung-adenocarcinoma-comparison-of-paired-fresh-frozen-and-formalin-fixed-paraffin-embedded-specimens
#14
Fan Zhang, Xing Zhao, Hongyan Dong, Jianzhen Xu
Circular RNA (circRNAs) is a novel class of endogenous non-coding RNAs which is widely involved in carcinogenesis. Archived formalin-fixed paraffin-embedded (FFPE) specimens represent valuable resources for cancer research. Currently there is a lack of systematic analysis on the feasibility of circRNAs expression analysis using FFPE samples. Here, we reported the first comparison study of circRNA expression from paired fresh frozen and FFPE specimens of lung adenocarcinoma. circRNAs expression of paired lung adenocarcinoma and adjacent normal samples, starting from either fresh frozen or FFPE materials, were analyzed via a high-throughput circRNA microarray...
April 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29678694/predicting-protein-submitochondrial-locations-by-incorporating-the-pseudo-position-specific-scoring-matrix-into-the-general-chou-s-pseudo-amino-acid-composition
#15
Wenying Qiu, Shan Li, Xiaowen Cui, Zhaomin Yu, Minghui Wang, Junwei Du, Yanjun Peng, Bin Yu
Mitochondrion are important organelles of most eukaryotes and play an important role in participating in various life activities of cells. However, some functions of mitochondria can only be achieved in specific submitochondrial location, the study of submitochondrial locations will help to further understand the biological function of protein, which is a hotspot in proteomics research. In this paper, we propose a new method for protein submitochondrial locations prediction. Firstly, the features of protein sequence are extracted by combining Chou's pseudo-amino acid composition (PseAAC) and pseudo-position specific scoring matrix (PsePSSM)...
April 17, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29678172/validity-of-international-classification-of-diseases-icd-coding-for-dengue-infections-in-hospital-discharge-records-in-malaysia
#16
Yuan-Liang Woon, Keng-Yee Lee, Siti Fatimah Zahra Mohd Anuar, Pik-Pin Goh, Teck-Onn Lim
BACKGROUND: Hospitalization due to dengue illness is an important measure of dengue morbidity. However, limited studies are based on administrative database because the validity of the diagnosis codes is unknown. We validated the International Classification of Diseases, 10th revision (ICD) diagnosis coding for dengue infections in the Malaysian Ministry of Health's (MOH) hospital discharge database. METHODS: This validation study involves retrospective review of available hospital discharge records and hand-search medical records for years 2010 and 2013...
April 20, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29675845/genome-sequence-and-description-of-gracilibacillus-timonensis-sp-nov-strain-marseille-p2481-t-a-moderate-halophilic-bacterium-isolated-from-the-human-gut-microflora
#17
Awa Diop, El Hadji Seck, Gregory Dubourg, Nicholas Armstrong, Caroline Blanc-Tailleur, Didier Raoult, Pierre-Edouard Fournier
Microbial culturomics represents an ongoing revolution in the characterization of the human gut microbiota. By using three culture media containing high salt concentrations (10, 15, and 20% [w/v] NaCl), we attempted an exhaustive exploration of the halophilic microbial diversity of the human gut and isolated strain Marseille-P2481 (= CSUR P2481 =  DSM 103076), a new moderately halophilic bacterium. This bacterium is a Gram-positive, strictly aerobic, spore-forming rod that is motile by use of a flagellum and exhibits catalase, but not oxidase activity...
April 19, 2018: MicrobiologyOpen
https://www.readbyqxmd.com/read/29675598/design-of-a-biorthogonal-wavelet-transform-based-r-peak-detection-and-data-compression-scheme-for-implantable-cardiac-pacemaker-systems
#18
Ashish Kumar, Manjeet Kumar, Rama Komaragiri
Bradycardia can be modulated using the cardiac pacemaker, an implantable medical device which sets and balances the patient's cardiac health. The device has been widely used to detect and monitor the patient's heart rate. The data collected hence has the highest authenticity assurance and is convenient for further electric stimulation. In the pacemaker, ECG detector is one of the most important element. The device is available in its new digital form, which is more efficient and accurate in performance with the added advantage of economical power consumption platform...
April 19, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/29675032/fspp-a-tool-for-genome-wide-prediction-of-smorf-encoded-peptides-and-their-functions
#19
Hui Li, Li Xiao, Lili Zhang, Jiarui Wu, Bin Wei, Ninghui Sun, Yi Zhao
smORFs are small open reading frames of less than 100 codons. Recent low throughput experiments showed a lot of smORF-encoded peptides (SEPs) played crucial rule in processes such as regulation of transcription or translation, transportation through membranes and the antimicrobial activity. In order to gather more functional SEPs, it is necessary to have access to genome-wide prediction tools to give profound directions for low throughput experiments. In this study, we put forward a functional smORF-encoded peptides predictor (FSPP) which tended to predict authentic SEPs and their functions in a high throughput method...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29675002/mutational-analysis-of-eggplant-latent-viroid-rna-circularization-by-the-eggplant-trna-ligase-in-escherichia-coli
#20
Teresa Cordero, Beltrán Ortolá, José-Antonio Daròs
Eggplant latent viroid (ELVd) is a relatively small non-coding circular RNA that induces asymptomatic infections in eggplants ( Solanum melongena L.). Like other viroid species that belong to the family Avsunviroidae , ELVd contains hammerhead ribozymes in the strands of both polarities that self-cleave RNAs producing terminal 5'-hydroxyl and 2',3'-cyclic phosphodiester groups. Available experimental data indicate that ELVd replicates in the chloroplasts of infected cells through a symmetric rolling-circle mechanism, in which RNA circularization is catalyzed by the chloroplastic isoform of the tRNA ligase...
2018: Frontiers in Microbiology
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