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Uric acid antioxidant

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https://www.readbyqxmd.com/read/27912887/nephroprotective-effects-of-%C3%AE-bisabolol-against-ischemic-reperfusion-acute-kidney-injury
#1
Tiago Lima Sampaio, Ramon Róseo Paula Pessoa Bezerra de Menezes, Marcus Felipe Bezerra da Costa, Gdayllon Cavalcante Meneses, Mauren Cristina Villalta Arrieta, Adriano José Maia Chaves Filho, Glayciane Bezerra de Morais, Alexandre Braga Libório, Renata Sousa Alves, Janaína Serra Azul Monteiro Evangelista, Alice Maria Costa Martins
BACKGROUND: Ischemia/reperfusion (I/R) in kidney is commonly related to acute kidney injury (AKI), essentially through oxidative stress. (-)-α-Bisabolol is a sesquiterpene isolated from the essential oil of a variety of plants, including chamomile, which has important antioxidant activity. STUDY DESIGN: This study intends to evaluate the nephroprotective activity of (-)-α-bisabolol (Bis) in both in vivo and in vitro models of kidney I/R. METHODS: Male Wistar rats were submitted to right nephrectomy, followed by ischemia by clamping of the renal artery in the left kidney for 60min...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27903424/inhibition-of-key-digestive-enzymes-related-to-hyperlipidemia-and-protection-of-liver-kidney-functions-by-cystoseira-crinita-sulphated-polysaccharide-in-high-fat-diet-fed-rats
#2
Amel Ben Gara, Rihab Ben Abdallah Kolsi, Rim Chaaben, Nadia Hammami, Majed Kammoun, Francesco Paolo Patti, Abdelfattah El Feki, Lotfi Fki, Hafedh Belghith, Karima Belghith
The objective of this current study was to investigate the possible hyperlipidemic and antioxidative effects of Cystoseira crinita sulfated polysaccharide (CCSP) in rats fed with a high-fat diet, exhibited an inhibitory activity on pancreatic lipase in vitro. In vivo administration of this extract to HFD-rats lowered body weight and potentially inhibited key enzymes of lipid metabolism and absorption as lipase activity in both plasma and small intestine, which led to a notable decrease of blood LDL- cholesterol (LDL-Ch) and triglycerides (TG) levels, and an increase in HDL-cholesterol (HDL-Ch) levels in HFD-rats...
November 27, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27901349/curcumin-improves-the-metabolic-syndrome-in-high-fructose-diet-fed-rats-role-of-tnf-%C3%AE-nf-%C3%AE%C2%BAb-and-oxidative-stress
#3
Mohamed Elsayed Kelany, Tahir M Hakami, Adel H Omar
This study aimed to investigate effects of curcumin on high fructose diet (HFD)-induced metabolic syndrome (MetS) in rats and the possible mechanisms involved. MetS was induced in male albino rats (n = 20), over 8 weeks, by 65% HFD. For 8-week experiment period, rats were assigned to 2 equal groups: curcumin-treated rats received curcumin (200 mg/kg, p.o, once daily) along with HFD, and untreated rats were fed with HFD only. We evaluated body mass (BM), systolic blood pressure (SBP), homeostasis model assessment of insulin resistance (HOMA-IR), and serum levels of glucose, insulin, leptin, total cholesterol (TC), triglycerides (TGs), uric acid, malondialdehyde (MDA; lipid peroxidation product), and tumor necrosis factor-α (TNF-α; inflammatory cytokine), and serum catalase (endogenous antioxidant) activity and immunohistochemical expression of nuclear factor κB (NF-κB; inflammation-related transcription factor) in hepatocytes...
August 17, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/27901184/evaluation-of-salivary-oxidative-parameters-in-overweight-and-obese-young-adults
#4
Eduardo Ottobelli Chielle, Jeferson Noslen Casarin
Background: Obesity is characterized by a deposition of abnormal or excessive fat in adipose tissue, and is linked with a risk of damage to several metabolic and pathological processes associated with oxidative stress. To date, salivary oxidative biomarkers have been minimally explored in obese individuals. Thus, the aim of this study was to assess the concentrations of salivary oxidative biomarkers (ferric-reducing antioxidant power, uric acid, sulfhydryl groups) and lipid peroxidation in obese and overweight young subjects...
November 24, 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27864790/understanding-pacing-postconditioning-mediated-cardiac-protection-a-role-of-oxidative-stress-and-a-synergistic-effect-of-adenosine
#5
Fawzi A Babiker, Aishah Al-Jarallah, Shaji Joseph
We and others have demonstrated a protective role for pacing postconditioning (PPC) against ischemia/reperfusion (I/R) injury in the heart; however, the underlying mechanisms behind these protective effects are not completely understood. In this study, we wanted to further characterize PPC-mediated cardiac protection, specifically identify optimal pacing sites; examine the role of oxidative stress; and test the existence of a potential synergistic effect between PPC and adenosine. Isolated rat hearts were subjected to coronary occlusion followed by reperfusion...
November 19, 2016: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27852844/bilirubin-levels-are-associated-with-contrast-induced-nephropathy-in-peripheral-artery-disease
#6
Ertan Vuruşkan, Erhan Saraçoğlu
The relationship between contrast-induced nephropathy (CIN) and oxidative mechanisms is well documented. Our aim was to demonstrate the possible relationship between CIN and serum bilirubin as an antioxidant molecule. This retrospective study included 359 patients with peripheral artery disease (PAD) who underwent peripheral diagnostic angiography; 179 developed CIN after the intervention and another 180 were the control group, matched for age, gender, and cardiovascular risk factors. Baseline, 48- to 72-hour, and 30-day laboratory values, major adverse cardiovascular events, and dialysis requirements were recorded...
November 15, 2016: Angiology
https://www.readbyqxmd.com/read/27846768/olive-oil-abrogates-acrylamide-induced-nephrotoxicity-by-modulating-biochemical-and-histological-changes-in-rats
#7
Imen Ghorbel, Awatef Elwej, Nesrine Fendri, Héla Mnif, Kamel Jamoussi, Tahia Boudawara, Naziha Grati Kamoun, Najiba Zeghal
Acrylamide (ACR) is one of the most important contaminants occurring in foods heated at high temperatures. The aim of this study is to investigate the protective efficacy of extra virgin olive oil (EVOO), a main component of the Mediterranean diet, against nephrotoxicity induced by ACR. Rats have received by gavage during 21 days either ACR (40 mg/kg body weight) or ACR-associated with EVOO (300 μl) or only EVOO (300 μl). Acrylamide induced nephrotoxicity as evidenced by an increase in malondialdehyde (MDA), hydrogen peroxide (H2O2), protein carbonyls (PCOs) and a decrease in glutathione, non-protein thiols (NPSHs), and vitamin C levels...
November 15, 2016: Renal Failure
https://www.readbyqxmd.com/read/27814700/the-hepatoprotective-activity-of-olive-oil-and-nigella-sativa-oil-against-ccl4-induced-hepatotoxicity-in-male-rats
#8
Madeha N Al-Seeni, Haddad A El Rabey, Mazin A Zamzami, Abeer M Alnefayee
BACKGROUND: Liver disease is the major cause of serious health problem leading to morbidity and mortality worldwide and the problem has increased in search for hepatotherapeutic agents from plants. The present study was designed to compare the probable hepatoprotective activity of olive oil and N. sativa oil on CCl4 induced liver damage in male rats. METHODS: Forty males of a new model of albino rats (Wistar strain) (175-205 g) were divided into four groups. The 1st Group (G1) was the negative control group, the remaining rats were injected with CCl4 (1 ml/kg body weight) with equal amount of olive oil on the 1st and 4th day of every week for 4 weeks...
November 4, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27805038/interactive-effect-of-serum-uric-acid-and-total-bilirubin-for-cardiovascular-disease-in-chinese-patients-with-type-2-diabetes
#9
Yanfeng Ren, Nan Jin, Tianpei Hong, Yiming Mu, Lixin Guo, Qiuhe Ji, Qiang Li, Xilin Yang, Linong Ji
Serum uric acid (SUA) at high levels and bilirubin at low levels were potent antioxidant but it was uncertain that whether SUA and total bilirubin (TBIL) had additive interaction for the risk of CVD in type 2 diabetes mellitus (T2DM). We conducted a cross-sectional survey of 6713 inpatients with T2DM and admitted to 81 tertiary care hospitals. CVD was defined as having either prior coronary heart disease or stroke or peripheral arterial disease. Binary logistic regression was used to estimate odds ratios of SUA and TBIL for CVD...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27794053/effects-of-dietary-threonine-levels-on-growth-performance-serum-biochemical-indexes-antioxidant-capacities-and-gut-morphology-in-broiler-chickens
#10
Y N Min, S G Liu, Z X Qu, G H Meng, Y P Gao
A dose-response experiment was conducted to investigate the impacts of dietary threonine (Thr) levels on growth performance, serum biochemical indices, antioxidant capacities, and gut morphology of broiler chickens. Four hundred and thirty-two 1-d-old commercial broilers were allocated to 4 treatments consisting of 6 replicates of 18 birds. The experimental treatments received the same Thr-deficient basal diet and were labeled as follows: 85%, 100%, 125%, and 150% of NRC (1994) recommendations. The results demonstrated that on 21 d and 42 d, average daily weight gain (ADG, 22 to 42 d, 0 to 42 d) increased quadratically or cubically as the inclusion of Thr increased, while feed conversion ratio (FCR, 0 to 21 d, 0 to 42 d) decreased quadratically or cubically as dietary Thr increase from 85% to 150%...
October 28, 2016: Poultry Science
https://www.readbyqxmd.com/read/27777867/multivariate-analysis-and-molecular-interaction-of-curcumin-with-ppar%C3%AE-in-high-fructose-diet-induced-insulin-resistance-in-rats
#11
Vasanthi Jayakumar, Shiek S S J Ahmed, Kesavarao Kumar Ebenezar
To investigate the effect of curcumin on the multivariate and docking analysis on peroxisome proliferator activated receptor-γ, the rats were fed with high fructose diet (Group 2) to induce insulin resistance and curcumin was co-administered orally (Group 4) for a period of 8 weeks and measured the biochemical parameters in blood, kidney and liver tissues. The results showed a significant (p ≤ 0.05) increase in the level of creatinine, glucose, insulin, low density lipoprotein, total cholesterol, triglyceride, urea, uric acid, very low density lipoprotein and decreased albumin, high density lipoprotein and total protein level in the blood of Group 2 when compared with Group 1 control rats...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27774887/lipoprotein-subfractions-uric-acid-and-cardiovascular-risk-in-end-stage-renal-disease-esrd-patients
#12
Anna Gluba-Brzózka, Beata Franczyk, Piotr Bartnicki, Magdalena Rysz-Górzyńska, Jacek Rysz
BACKGROUND: Chronic kidney disease (CKD) poses a worldwide public health problem. CKD is an independent risk factor for cardiovascular disease (CVD). OBJECTIVE: The aim of this study was to assess the cardiovascular risk in ESRD patients and to evaluate the relationship between serum uric acid and lipoprotein subfractions. METHODS: The study group consisted of 66 patients on dialysis and control group of 25 healthy volunteers. Concentration of HDL and LDL subfractions were analysed with Lipoprint™...
October 21, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27769920/allopurinol-attenuates-rhabdomyolysis-associated-acute-kidney-injury-renal-and-muscular-protection
#13
Pedro H F Gois, Daniele Canale, Rildo A Volpini, Daniela Ferreira, Mariana M Veras, Vinicius Andrade-Oliveira, Niels O S Câmara, Maria H M Shimizu, Antonio C Seguro
BACKGROUND: Acute kidney injury (AKI) is the most severe complication of rhabdomyolysis. Allopurinol (Allo), a xanthine oxidase inhibitor, has been in the spotlight in the last decade due to new therapeutic applications related to its potent antioxidant effect. The aim of this study was to evaluate the efficacy of Allo in the prevention and treatment of rhabdomyolysis-associated AKI. METHODS: Male Wistar rats were divided into five groups: saline control group; prophylactic Allo (300mg/L of drinking water, 7 days); glycerol (50%, 5ml/kg, IM); prophylactic Allo + glycerol; and therapeutic Allo (50mg/Kg, IV, 30min after glycerol injection) + glycerol...
October 18, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27756197/protective-effect-of-l-glutamine-against-diabetes-induced-nephropathy-in-experimental-animal-role-of-kim-1-ngal-tgf-%C3%AE-1-and-collagen-1
#14
Smeeta Sadar, Dipti Kaspate, Neeraj Vyawahare
Diabetic nephropathy is a serious microvascular complication and one of the main causes of end-stage renal disease. L-Glutamine (LG) is naturally occurring amino acids with antidiabetic and antioxidant potential. The aim of present investigation was to evaluate the potential of LG against streptozotocin (STZ)-induced diabetic nephropathy (DN) in laboratory rats. DN was induced in male Wistar rats (200-220 g) by intraperitoneal administration of STZ (55 mg/kg). Animals were treated orally with either distilled water (10 mg/kg) or LG (250, 500, and 1000 mg/kg) or Sitagliptin (5 mg/kg)...
October 2016: Renal Failure
https://www.readbyqxmd.com/read/27747873/antioxidants-from-black-and-green-tea-from-dietary-modulation-of-oxidative-stress-to-pharmacological-mechanisms
#15
REVIEW
Ilaria Peluso, Mauro Serafini
The consumption of tea (Camellia sinensis) has been correlated with a low incidence of chronic pathologies, such as cardiovascular disease and cancer, in which oxidative stress plays a critical role. Tea catechins and theaflavins are, respectively, the bioactive phytochemicals responsible for the antioxidant activity of green tea (GT) and black tea (BT). In addition to their redox properties, tea catechins and theaflavins could have also pharmacological activities, such as the ability to lower glucose, lipid and uric acid (UA) levels...
October 16, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27743598/exploration-of-the-therapeutic-potential-effect-of-sepia-officinalis-in-animal-model-of-sepsis-induced-by-cecal-ligation-and-puncture
#16
Asmaa Abd El-Aleem Abd El-Latif, Amany Ahmed Sayed, Amel Mahmoud Soliman, Sohair Ramadan Fahmy
OBJECTIVE: The present investigation explored the therapeutic potential effect of Sepia officinalis body tissue (SOBT) and Sepia officinalis polysaccharide (SOP) extracts, in animal model of sepsis [induced by cecal ligation and puncture (CLP)]. MATERIALS AND METHODS: Experimental animals were divided into 4 groups, Group 1: Sham control rats. Group 2: Septic rats. Group 3: Septic rats treated with methanolic extract of Sepia officinalis body tissue (SOBT) (500mg/kg body weight) for 2days...
December 2016: Injury
https://www.readbyqxmd.com/read/27719930/highly-selective-and-sensitive-determination-of-several-antioxidants-in-human-breast-milk-using-high-performance-liquid-chromatography-based-on-ag-iii-complex-chemiluminescence-detection
#17
Li Ma, Hongmei Shi, Kaoqi Lian, Yingfei Diao, Yang Chen, Chunling Ma, Weijun Kang
Ascorbic acid (AA), uric acid (UA) and glutathione (GSH) are the most important water-soluble antioxidants. The concentrations of GSH and glutathione disulfide (GSSG) and their molar ratio are the indicators of oxidative stress. Little is known about the contents of UA, GSH and GSSG in human milk; a reliable and sensitive method to monitor the concentrations of the four compounds simultaneously in human milk is of critical importance. A new method for separation and quantification of these water-soluble antioxidants by HPLC coupled with Ag(III) chemiluminescence detector has been developed in this work with better recoveries...
March 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27710898/nephro-protective-action-of-p-santalinus-against-alcohol-induced-biochemical-alterations-and-oxidative-damage-in-rats
#18
Saradamma Bulle, Vaddi Damodara Reddy, Ananda Vardhan Hebbani, Pannuru Padmavathi, Chandrasekhar Challa, Pavan Kumar Puvvada, Elisha Repalle, Devanna Nayakanti, Chandrakala Aluganti Narasimhulu, Varadacharyulu Nallanchakravarthula
The present study investigated the antioxidant potential of P. santalinus heartwood methanolic extract (PSE) against alcohol-induced nephro-toxicity. The results indicated an increase in the concentration of kidney damage plasma markers, urea and creatinine with a concomitant decrease in the concentration of uric acid in alcohol-administered rats. A significant decrease in plasma electrolytes and mineral levels with increased kidney thiobarbituric acid reactive substances (TBARS) and nitric oxide (NOx) levels was also observed...
October 3, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27709390/audiovisual-stimulation-modulates-physical-performance-and-biochemical-and-hormonal-status-of-athletes
#19
M S Golovin, M S Golovin, R I Aizman
We studied the effect of audiovisual stimulation training course on physical development, functional state of the cardiovascular system, blood biochemical parameters, and hormonal status of athletes. The training course led to improvement of physical performance and adaptive capacities of the circulatory system, increase in plasma levels of total protein, albumin, and glucose and total antioxidant activity, and decrease in triglyceride, lipase, total bilirubin, calcium, and phosphorus. The concentration of hormones (cortisol, thyrotropin, triiodothyronine, and thyroxine) also decreased under these conditions...
September 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27701137/oxidative-stress-histopathological-and-electron-microscopic-alterations-induced-by-dimethylnitrosamine-in-renal-male-mice-and-the-protective-effect-of-%C3%AE-lipoic-acid
#20
Reham Z Hamza, Hayat A A Ismail, Nahla S El-Shenawy
BACKGROUND: Dimethylnitrosamine (DMN) is a waste product of several industrial processes. Alpha-lipoic acid (ALA) is a vitamin-like chemical also called as an antioxidant. Therefore, the study was designed to investigate the potential benefits of ALA in reducing the nephropathy of DMN in male mice. METHODS: Animals were divided into 6 groups (n=8) and received their treatment for 4 weeks as follows: groups 1-4 served as control, ALA-treatment (16.12 mg/kg), DMN low dose treatment and DMN high dose treatment, respectively...
October 4, 2016: Journal of Basic and Clinical Physiology and Pharmacology
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