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Uric acid antioxidant

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https://www.readbyqxmd.com/read/28720209/the-influence-of-oxazaphosphorine-agents-on-kidney-function-in-rats
#1
Łukasz Dobrek, Beata Skowron, Agnieszka Baranowska, Klaudia Płoszaj, Dorota Bądziul, Piotr Thor
BACKGROUND AND OBJECTIVE: The application of cytostatic oxazaphosphorines such as cyclophosphamide (CP) and ifosfamide (IF) is associated with the risk of kidney damage that, depending on the type of drug, dose and route of administration, adopts a different clinical entity and severity. The aim of our study was to assess the influence of CP and IF on the kidney histology and function in rats intraperitoneally treated with four doses of either CP or IF. MATERIALS AND METHODS: A total of 30 rats were divided into three groups (10 in each group): group 1 (control), sham treated with saline solution, group 2 (treated with 75mg/kg b...
July 2, 2017: Medicina
https://www.readbyqxmd.com/read/28717317/effect-of-season-on-physiological-biochemical-hormonal-and-oxidative-stress-parameters-of-indigenous-sheep
#2
Sawankumar D Rathwa, A A Vasava, M M Pathan, S P Madhira, Y G Patel, A M Pande
AIM: This study was conducted to evaluate the impact of summer and winter season on physiological, biochemical, hormonal, and antioxidant parameters in Indigenous sheep. MATERIALS AND METHODS: The research was carried out during summer and winter season. 8 adult apparently healthy female sheep (aged 2-4 years) of similar physiological status were selected. Daily ambient temperature and relative humidity were recorded to calculate the temperature-humidity index (THI)...
June 2017: Veterinary World
https://www.readbyqxmd.com/read/28707864/oxidative-stress-antioxidants-and-lipid-profile-in-the-serum-and-saliva-of-individuals-with-coronary-heart-disease-is-there-a-link-with-periodontal-health
#3
Natheer H Al-Rawi, Alaa M Shahid
BACKGROUND: Oxidative stresses and dyslipidemia are an important risk factor in the development of coronary atherosclerotic complications like angina pectoris and myocardial infarction. The aim of this study was to find the relationship between the salivary lipid profile, lipid peroxidation and antioxidants and the periodontal health status of patients with acute coronary heart disease. METHODS: Forty s who had experienced a recent attack of angina pectoris or myocardial infarction and another 40 noncardiac patients matched for age, sex and residence (control) were recruited...
July 12, 2017: Minerva Stomatologica
https://www.readbyqxmd.com/read/28705092/serum-allantoin-and-aminothiols-as-biomarkers-of-chronic-heart-failure
#4
Elizabeth Caussé, Pauline Fournier, Jérome Roncalli, Robert Salvayre, Michel Galinier
Background Oxidative stress (OS) represents the primary mediator of chronic heart failure (CHF) development and progression. It is well established that homocysteine is able to generate reactive oxygen species. Small amounts of allantoin in human serum result from free radical action on urate and may provide a stable marker for in vivo free radical activity. To investigate whether some easily measurable indexes such as antioxidants (uric acid, glutathione) and related molecules (allantoin, homocysteine and cysteine) can serve as OS biomarkers...
July 14, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28704756/protective-role-of-dietary-spirulina-platensis-against-diazinon-induced-oxidative-damage-in-nile-tilapia-oreochromis-niloticus
#5
Nevien K M Abdelkhalek, Ismail A M Eissa, Eman Ahmed, Omnia E Kilany, Mohamed El-Adl, Mahmoud A O Dawood, Ahmed M Hassan, Mohamed M Abdel-Daim
The current study was performed to investigate the ameliorating effect of dietary supplementation of 0.5 and 1% Spiurolina platensis (SP) diet against the sub-acute toxicity of diazinon (DZN) 0.28mg/L in Nile tilapia. At the end of experiment after 28days, hepatic and renal damage markers (aspartate transaminase, alanine transaminase, alkaline phosphatase, urea, uric acid and creatinine), serum biochemical parameters (total proteins, albumin, cholesterol and glucose) and tissue antioxidant status (superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione and malondialdehyde) were detesrmined...
July 5, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28698489/dietary-vitamin-c-e-and-%C3%AE-carotene-intake-does-not-significantly-affect-plasma-or-salivary-antioxidant-indices-and-salivary-c-reactive-protein-in-older-subjects
#6
Anna Gawron-Skarbek, Agnieszka Guligowska, Anna Prymont-Przymińska, Małgorzata Godala, Agnieszka Kolmaga, Dariusz Nowak, Franciszek Szatko, Tomasz Kostka
It is not clear whether habitual dietary intake influences the antioxidant or inflammatory status. The aim of the present study was to assess the impact of antioxidative vitamins C, E, and β-carotene obtained from daily food rations on plasma and salivary Total Antioxidant Capacity (TAC), uric acid and salivary C-reactive protein (CRP). The study involved 80 older subjects (66.9 ± 4.3 years), divided into two groups: group 1 (n = 43) with lower and group 2 (n = 37) with higher combined vitamins C, E and β-carotene intake...
July 9, 2017: Nutrients
https://www.readbyqxmd.com/read/28686978/sinapic-acid-modulates-nrf2-ho-1-signaling-pathway-in-cisplatin-induced-nephrotoxicity-in-rats
#7
Mushtaq Ahmad Ansari
BACKGROUND: Cisplatin-induced nephrotoxicity is related to increased reactive oxygen species and inflammatory cytokines in the kidney. Sinapic acid (SA) has both antioxidant and anti-inflammatory activities. AIMS: We determined the effects of SA on cisplatin-induced nephrotoxicity in rats, and the potential mechanisms by which it augments antioxidant responses and attenuates nephrotoxicity related to oxidative/nitrosative stress, apoptosis, and inflammation. METHODS: Kidney function markers (i...
July 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28675793/chelating-effects-of-carnosine-in-ameliorating-nickel-induced-nephrotoxicity-in-rats
#8
Parisa Hasanein, Zhila Felegari
The kidney is one of the main organs affected by nickel (Ni) toxicity. We investigated the protective effects of carnosine on Ni- induced oxidative stress in kidney of rats. Animals received NiSO4 (20 mg/kg/day i.g.) and/or carnosine (10 mg/kg/day, i.g.) for 21 days and then were evaluated for biochemical, molecular and histopathological alterations. Ni caused an increase in renal levels of malondialdehydes and a decrease in reduced glutathione, catalase and superoxide dismutase levels and total antioxidant capacity...
July 4, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28671197/protective-effects-of-fraction-4a-of-polysaccharides-isolated-from-lycium-barbarum-against-kbro3-induced-renal-damage-in-rats
#9
J Li, M Shi, B Ma, Y Zheng, R Niu, K Li
Potassium bromate (KBrO3) is widely used as a food additive and is a major by-product of water disinfection. The aim of this study was to investigate the protective effects of fraction 4a of polysaccharides isolated from Lycium barbarum (LBP-4a) against renal damage induced by KBrO3 in rats and to determine the relevant mechanisms behind these effects. Male Wistar rats were divided into a normal control group, a KBrO3 control group, and LBP-4a(L) and LBP-4a(H) groups. With the exception of the normal control group, the rats in the other three groups were administered KBrO3 by intraperitoneal injection to induce renal damage...
July 19, 2017: Food & Function
https://www.readbyqxmd.com/read/28670523/evaluation-of-the-protective-effect-of-hydro-alcoholic-extract-of-raspberry-fruit-on-aquaporin1-expression-in-rats-kidney-treated-by-methotrexate
#10
Saeideh Khoshnoud, Homa Mohseni Kouchesfahani, Mohammad Nabiuni
OBJECTIVE: Methotrexate (MTX) is an antimetabolite drug commonly prescribed for the various cancers and autoimmune diseases. Despite its considerable therapeutic effects, nephrotoxicity is the most important side-effect of treatment with MTX. Aquaporin1 (AQP1) is a water channel proteins which is present in mammalian kidney. Raspberry fruit with antioxidant properties is able to protect biological systems from the harmful effects of free radicals. The purpose of this study was to investigate the effect of raspberry extract on expression of AQP1 and the MTX-induced nephrotoxicity in rats...
July 2017: Cell Journal
https://www.readbyqxmd.com/read/28668647/toxicological-evaluation-of-the-aqueous-whole-plant-extract-of-aerva-lanata-l-juss-ex-schult-amaranthaceae
#11
Kayode S Omotoso, Flora R Aigbe, Olanrewaju A Salako, Micah C Chijioke, Oluwafunmilayo O Adeyemi
ETHNOPHARMACOLOGICAL RELEVANCE: Aerva lanata (L.) of the family Amaranthaceae is a Nigerian medicinal plant used traditionally for the management of lithiasis, headache, renal disorder, haematemesis, bronchitis, nasal bleeding, cough, scorpion stings, fractures and spermatorrhoea. Studies that show the pharmacological basis for some of such uses have been reported. There is, however, no scientific report on its toxicity profile to the best of our knowledge. AIM OF THE STUDY: This study was therefore aimed at investigating the toxicity profile of the aqueous extract of Aerva lanata...
June 28, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28667579/the-impact-of-fish-oil-and-wheat-germ-oil-combination-on-mineral-bone-and-inflammatory-markers-in-maintenance-hemodialysis-patients-a-randomized-double-blind-placebo-controlled-clinical-trial
#12
Hadeer Zakaria, Tarek M Mostafa, Gamal A El-Azab, Ahmed M Abd El Wahab, Heba Elshahawy, Nagy Ah Sayed-Ahmed
PURPOSE: This study aimed to examine the impact of combined supplementation of fish oil (FO) with antioxidants like wheat germ oil (WGO) on mineral-bone and inflammatory markers in maintenance HD patients. METHODS: This randomized, double-blind, placebo-controlled trial involved 46 HD patients who were randomly assigned into two groups to receive daily 3000 mg of FO [1053 mg omega-3 fatty acids (ω-3 FAs)] plus 300 mg of WGO [0.765 mg vitamin E] or placebo for 4 months...
June 30, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28655421/synthesis-and-evaluation-of-hydroxychalcones-as-multifunctional-non-purine-xanthine-oxidase-inhibitors-for-the-treatment-of-hyperuricemia
#13
Zhaodi Xie, Xiaoting Luo, Zhuan Zou, Xiao Zhang, Feifei Huang, Ruishan Li, Shijie Liao, Yun Liu
A series of hydroxychalcone derivatives have been designed, synthesized and evaluated for human xanthine oxidase (XO) inhibitory activity. Most of the tested compounds acted moderate XO inhibition with IC50 values in the micromolar rang. Molecular docking and kinetic studies have been performed to explain the binding modes of XO with the selected compounds. In addition, in vitro antioxidant screening results indicated that some of the hydroxychalcones possessed good anti-free radical activities. Furthermore, the preferred compounds 16 and 18 were able to significantly inhibit hepatic xanthine oxidase activity and reduced serum uric acid level of hyperuricemic mice in vivo...
August 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28638348/the-redox-balance-in-erythrocytes-plasma-and-periosteum-of-patients-with-titanium-fixation-of-the-jaw
#14
Jan Borys, Mateusz Maciejczyk, Adam J Krȩtowski, Bozena Antonowicz, Wioletta Ratajczak-Wrona, Ewa Jabłońska, Piotr Załęski, Danuta Waszkiel, Jerzy R Ładny, Piotr Żukowski, Anna Zalewska
Titanium miniplates and screws are commonly used for fixation of jaw fractured or osteotomies. Despite the opinion of their biocompatibility, in clinical practice symptoms of chronic inflammation around the fixation develop in some patients, even many years after the application of miniplates and screws. The cause of these complications is still an unanswered question. Taking into account that oxidative stress is one of the toxic action of titanium, we have evaluated the antioxidant barrier as well as oxidative stress in the erythrocytes, plasma and periosteum covering the titanium fixation of the jaw...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28629212/a-study-of-the-modulating-action-of-quercetin-on-biochemical-and-histological-alterations-induced-by-lead-exposure-in-the-liver-and-kidney-of-rats
#15
Ghena M. Mohammed, Azza Sedky, Hany Elsawy
Lead is a highly toxic metal and a very potent poison. Lead poisoning is a serious condition but can be treated. Quercetin is a flavonoid with many beneficial uses. The aim of the present study was to investigate the possible modulating action of quercetin as a model of an antioxidant against the toxic effects of lead acetate on liver and kidneys of rats. Rats were randomly divided into four groups: (i) saline group (control); (ii) lead group received i.p. lead acetate (20 mg/kg b.w.); (iii) quercetin group received i...
June 30, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/28620773/antioxidant-uric-acid-in-treated-and-untreated-subjects-with-major-depressive-disorder-a-meta-analysis-and-meta-regression
#16
Francesco Bartoli, Giulia Trotta, Cristina Crocamo, Maria Rosaria Malerba, Massimo Clerici, Giuseppe Carrà
Pathophysiological mechanisms of major depressive disorder (MDD) seem to be associated with oxidative stress pathways and altered purinergic metabolism. We conducted a systematic review and meta-analysis to estimate if subjects with MDD might have reduced levels of antioxidant uric acid, considering also potential influence of antidepressant treatment. We searched the main Electronic Databases, identifying 14 studies that met our inclusion criteria. Meta-analyses were carried out generating pooled Hedges' g and mean differences (MDs), using random-effects models...
June 15, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28615022/correlation-of-retinal-nerve-fibre-layer-and-macular-thickness-with-serum-uric-acid-among-type-2-diabetes-mellitus
#17
Munisamy-Naidu Vinuthinee-Naidu, Embong Zunaina, Anuar Azreen-Redzal, Naing Nyi-Nyi
BACKGROUND: Uric acid is a final breakdown product of purine catabolism in humans. It's a potent antioxidant and can also act as a pro-oxidant that induces oxidative stress on the vascular endothelial cells, thus mediating progression of diabetic related diseases. Various epidemiological and experimental evidence suggest that uric acid has a role in the etiology of type 2 diabetes mellitus. We conducted a cross-sectional study to evaluate the correlation of retinal nerve fibre layer (RNFL) and macular thickness with serum uric acid in type 2 diabetic patients...
June 14, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28609463/uric-acid-an-important-antioxidant-contributing-to-survival-in-termites
#18
Eisuke Tasaki, Hiroki Sakurai, Masaru Nitao, Kenji Matsuura, Yoshihito Iuchi
Reactive oxygen species (ROS) are generated spontaneously in all organisms and cause oxidative damage to biomolecules when present in excess. Accumulated oxidative damage accelerates aging; enhanced antioxidant capacity may be a positive factor for longevity. Recently, numerous studies of aging and longevity have been performed using short-lived animals, however, longevity mechanisms remain unknown. Here we show that a termite Reticulitermes speratus that is thought to be long-lived eusocial insect than other solitary insects uses large quantities of uric acid as an antioxidant against ROS...
2017: PloS One
https://www.readbyqxmd.com/read/28603225/cross-over-trial-of-febuxostat-and-topiroxostat-for-hyperuricemia-with-cardiovascular-disease-trofeo-trial
#19
Akira Sezai, Kazuaki Obata, Keisuke Abe, Sakie Kanno, Hisakuni Sekino
BACKGROUND: We previously reported that febuxostat was more effective for hyperuricemia than allopurinol. The efficacy, however, of topiroxostat (a novel xanthine oxidase reductase inhibitor similar to febuxostat), for hyperuricemia is unknown.Methods and Results:Patients with cardiovascular disease and hyperuricemia, in whom serum uric acid (s-UA) was controlled at ≤6 mg/dL, were eligible for enrollment. Fifty-five patients were randomized to receive either febuxostat or topiroxostat for 6 months and were switched to the other drug for the following 6 months...
June 9, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28580518/the-role-of-free-radical-oxidation-in-the-development-of-experimental-urate-nephropathy
#20
V Yu Perfil'ev, Ya F Zverev, A Yu Zharikov, V M Bryukhanov
We studied the dynamics of activity of antioxidant enzymes under conditions of experimental urate kidney damage in rats. Combined administration of uric (0.145 g) and oxonium (0.3 g) acids to laboratory animals modulated free radical oxidation in the kidneys, and especially, in the blood. During the week 1, activity of free radical processes decreased, which was probably determined by the antioxidant effect of increasing blood concentration of uric acid. After 2-3 weeks of experimental pathology, the development of oxidative stress was observed, probably due to predominance of prooxidant activity of uric acid...
June 5, 2017: Bulletin of Experimental Biology and Medicine
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