keyword
https://read.qxmd.com/read/38529813/water-soluble-phenolics-from-phoenix-dactylifera-fruits-as-potential-reno-protective-agent-against-cisplatin-induced-toxicity-pre-and-post-treatment-strategies
#1
JOURNAL ARTICLE
Omowumi Oyeronke Adewale, Roseline Fadera Oyelola, Oluwatosin Adefunke Adetuyi, Oluwaseun Abraham Adebisi, Damilare Adedayo Adekomi, Johnson Olaleye Oladele
Nephrotoxicity is the major side effect of cisplatin, an effective platinum-based chemotherapeutic drug that is applicable in the treatment of several solid-tissue cancers. Studies have indicated that certain water-soluble phenolics offer renal protection. Thus, this study investigates the role of pre and post-treatment of rats with water-soluble phenolics from Phoenix dactylifera (PdP) against nephrotoxicity induced by cisplatin. Rats were either orally pretreated or post-treated with 200 mg/kg body weight of PdP before or after exposure to a single therapeutic dose of cisplatin (5 mg/kg body weight) for 7 successive days intraperitoneally...
March 26, 2024: Drug and Chemical Toxicology
https://read.qxmd.com/read/38526565/catalase-and-uric-acid-prevent-morphological-damage-to-the-sperm-flagella-of-colossoma-macropomum-during-96-hours-at-low-storage-temperatures
#2
JOURNAL ARTICLE
Yugo M Pastrana, Jaydione L Marcon, Amanda P de Amaral, Francisco Bruno P Santos, Emerson S Lima, Leonard D R Acho, Rodrigo Otávio S de Souza, Carolina C Grando, Danilo P Streit Junior, Leandro Godoy
Oxidative stress is one of the main causes of loss of sperm function during chilled storage. The aim of the current study was to evaluate the effects of a fructose-based extender, which was supplemented with catalase or uric acid, on the motility, viability, morphological integrity, and lipid peroxidation (LPO) of Colossoma macropomum spermatozoa. Sperm was diluted in extenders containing catalase (0; 0.1; 0.8; and 1.5 kU/L) or uric acid (0; 0.25; 0.5; and 1.0 mmol/L) and then stored at 4.3 ± 0...
March 22, 2024: Biopreservation and Biobanking
https://read.qxmd.com/read/38525131/n-acetylcysteine-protects-against-diazinon-induced-histopathological-damage-and-apoptosis-in-renal-tissue-of-rats
#3
JOURNAL ARTICLE
Gaiqin Dong, Qingfeng Li, Chun Yu, Qing Wang, Danhua Zuo, Xiaozhong Li
Diazinon (DZN) is a member of organophosphorus insecticides that has cytotoxic effects on different organs. n-Acetyl cysteine (NAC) is a widely used antioxidant in clinical, in vivo and in vitro studies. We evaluated the protective role of NAC against DZN-induced toxicity in kidney tissue of Wistar rats. 30 male Wistar rats were divided into 5 groups of control, single dose of DZN, continuous dose of DZN, single doses of DZN + NAC and continuous doses of DZN + NAC. Kidney function test (blood urea nitrogen, creatinine and uric acid) was provided...
April 2024: Toxicological Research
https://read.qxmd.com/read/38513550/in-house-ammonia-induced-lung-impairment-and-oxidative-stress-of-ducks
#4
JOURNAL ARTICLE
Bo Liu, Yongjie Yang, Yang Fu, Yue Zhao, Wenjing Chen, Shi Wei, Xin Zuo, Yongwen Zhu, Hui Ye, Minhong Zhang, Peng Zhang, Lin Yang, Wence Wang, Jie Pan
Ammonia (NH3 ) is a toxic gas that in intensive poultry houses, damages the poultry health and induces various diseases. This study investigated the effects of NH3 exposure (0, 15, 30, and 45 ppm) on growth performance, serum biochemical indexes, antioxidative indicators, tracheal and lung impairments in Pekin ducks. A total of 288 one-day-old Pekin male ducks were randomly allocated to 4 groups with 6 replicates and slaughtered after the 21-d test period. Our results showed that 45 ppm NH3 significantly reduced the average daily feed intake (ADFI) of Pekin ducks...
March 6, 2024: Poultry Science
https://read.qxmd.com/read/38511628/investigation-of-the-protective-effect-of-chitosan-against-arsenic-induced-nephrotoxicity-and-oxidative-damage-in-rat-kidney-tissue
#5
JOURNAL ARTICLE
K İrak, Ö Y Çelik, M Bolacalı, T Tufan, S Özcan, S Yıldırım, I Bolat
Arsenic is an important metalloid that can cause poisoning in humans and domestic animals. Exposure to arsenic causes cell damage, increasing the production of reactive oxygen species. Chitosan is a biopolymer obtained by deacetylation of chitin with antioxidant and metal ion chelating properties. In this study, the protective effect of chitosan on arsenic-induced nephrotoxicity and oxidative damage was investigated. 32 male Wistar-albino rats were divided into 4 groups of 8 rats each as control group (C), chitosan group (CS group), arsenic group (AS group), and arsenic+chitosan group (AS+CS group)...
March 20, 2024: Polish Journal of Veterinary Sciences
https://read.qxmd.com/read/38509880/lower-serum-uric-acid-and-impairment-of-right-cerebral-hemisphere-structural-brain-networks-are-related-to-depressive-symptoms-in-cerebral-small-vessel-disease-a-cross-sectional-study
#6
JOURNAL ARTICLE
Lei Yu, Ming Yi, Jiayu Guo, Jinbiao Li, Huixing Zeng, Liqian Cui, Xiangming Xu, Gang Liu, Yuhua Fan, Jinsheng Zeng, Shihui Xing, Yicong Chen, Meng Wang, Shuangquan Tan, Leow Yi Jin, Dilip Kumar, Ashwati Vipin, Soo See Ann, Fatin Zahra Binte Zailan, Gurveen Kaur Sandhu, Nagaendran Kandiah, Chao Dang
Cerebral small vessel disease (SVD) may be associated with an increased risk of depressive symptoms. Serum uric acid (SUA), an antioxidant, may be involved in the occurrence and development of depressive symptoms, but the mechanism remains unknown. Moreover, the relationship between structural brain networks and SUA has not been explored. This study examined the relationship between SUA and depressive symptoms in patients with SVD using graph theory analysis. We recruited 208 SVD inpatients and collected fasting blood samples upon admission...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38498316/piperine-improves-hyperuricemic-nephropathy-by-inhibiting-urat1-glut9-and-the-akt-mtor-pathway
#7
JOURNAL ARTICLE
Lu Li, Kunlu Zhao, Jian Luo, Jinhong Tian, Fengxin Zheng, Xueman Lin, Zijun Xie, Heyang Jiang, Yongmei Li, Zean Zhao, Ting Wu, Jianxin Pang
Uncontrolled hyperuricemia often leads to the development of hyperuricemic nephropathy (HN), characterized by excessive inflammation and oxidative stress. Piperine, a cinnamic acid alkaloid, possesses various pharmacological activities, such as antioxidant and anti-inflammatory effects. In this study, we intended to investigate the protective effects of piperine on adenine and potassium oxonate-induced HN mice and a uric-acid-induced injury model in renal tubular epithelial cells (mRTECs). We observed that treatment with piperine for 3 weeks significantly reduced serum uric acid levels and reversed kidney function impairment in mice with HN...
March 18, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38448202/analysis-of-cantharidin-induced-kidney-injury-and-the-protective-mechanism-of-resveratrol-in-mice-determined-by-liquid-chromatography-mass-spectrometry-based-metabonomics
#8
JOURNAL ARTICLE
Yuanyuan Xiao, Ruxia Liu, Xiaoyue Zhang, Yaofeng Li, Fang Peng, Wenchao Tang
Cantharidin (CTD) is the main active component in the traditional Chinese medicine Mylabris and an effective anti-tumor agent. However, it is relatively toxic and exhibits nephrotoxicity, which limits its clinical use. However, its toxic mechanism is not clear. The toxic effects of CTD exposure on the kidney and the protective effect of resveratrol (RES) were studied in a mouse model, by determination of serum biochemical and renal antioxidant indicators, histopathological and ultrastructural observation, and metabonomics...
March 6, 2024: Journal of Applied Toxicology: JAT
https://read.qxmd.com/read/38440749/anthelmintic-and-therapeutic-effects-of-the-biogenic-zinc-oxide-nanoparticles-against-acute-kidney-injury-induced-by-parascaris-equorum-infection-in-rats
#9
JOURNAL ARTICLE
Sara Bayoumi Ali, Ayman Saber Mohamed, Sohair R Fahmy, Manal El-Garhy, Mohamed R Mousa, Fathy Abdel-Ghaffar
Complications of parasite infections, especially kidney disease, have been linked to poorer outcomes. Acute kidney damage, glomerulonephritis, and tubular dysfunction are the most prevalent renal consequences of Parascaris equorum infection. The purpose of this study was to determine the pharmacological effects of green-produced zinc oxide nanoparticles (ZnO NPs) on P. equorum infection in male Wistar rats. Thirty-six male rats were divided into two groups of 18 each: infected and non-infected. Both groups were separated into three subgroups, each of which received distilled water, 30 mg/kg ZnO NPs, and 60 mg/kg ZnO NPs...
March 2024: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://read.qxmd.com/read/38438314/impact-of-uricosurics-on-mortality-outcomes-in-patients-with-covid-19-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#10
JOURNAL ARTICLE
Chia Siang Kow, Dinesh Sangarran Ramachandram, Syed Shahzad Hasan, Kaeshaelya Thiruchelvam
OBJECTIVES: To determine risks associated with uricosurics in COVID-19 patients. METHODS: A systematic review and meta-analysis was conducted by systematically searching electronic databases. KEY FINDINGS: The pooled analysis of the included trials revealed that the use of uricosurics was not associated with the risk of mortality (pooled odds ratio [OR] = 1.03, 95% confidence interval [CI]: 0.94-1.12). However, there is a potential mortality benefit associated with the use of ascorbic acid (pooled OR = 0...
March 4, 2024: International Journal of Pharmacy Practice
https://read.qxmd.com/read/38415887/antiurolithiatic-effects-of-cassia-fistula-lin-fruit-extracts-on-ethylene-glycol-induced-nephrolithiasis-in-rats
#11
JOURNAL ARTICLE
Nasrin Partovi, S Jamilaldin Fatemi, Mohammad Reza Ebadzadeh
Urinary stones are a growing disease that results from pathological biomineralization. Cassia fistula Lin. is traditionally used to treat urinary stones. However, no scientific evidence is available to prove its antilithiatic effect. This study evaluates the antilithiatic potential of aqueous and ethanolic extract of Cassia fistula Lin. fruit (Cff) against calcium oxalate kidney stones. Forty-two male Wistar rats were divided into seven groups (n = 6/group): Group I (control), Group II (rats treated with ethylene glycol and ammonium chloride developed nephrolithiasis after 28 days), Group III (lithiatic rats receiving distilled water for 30 days), Group IV and V (lithiatic rats receiving aqueous extract of Cff at doses of 1 and 100 mg/kg body weight for 30 days, respectively) and Group VI and VII (lithiatic rats receiving ethanolic extract of Cff at doses of 1 and 100 mg/kg body weight for 30 days, respectively)...
February 28, 2024: Microscopy Research and Technique
https://read.qxmd.com/read/38403004/phytochemical-profiling-and-nephroprotective-potential-of-ethanolic-leaf-extract-of-polyalthia-longifolia-against-cisplatin-induced-oxidative-stress-in-rat-model
#12
JOURNAL ARTICLE
Divya Bisht, Deena Prakash, Ramesh Kumar, Arvind Kumar Shakya, Sadhana Shrivastava
ETHNOPHARMACOLOGICAL RELEVANCE: Kidney problems are becoming more common globally and are considered a major health issue in the modern world with high mortality rate. Polyalthia longifolia (Sonn.) Thwaites is a tropical ethnomedicinal plant used to treat various diseases like diabetes, hypertension and urinary disorders and possess antioxidant and anti-inflammatory properties. AIM OF THE STUDY: This study aimed to investigate the phytochemical composition of 70% ethanolic leaf extract of Polyalthia longifolia (Sonn...
February 23, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38397809/gender-influence-on-xor-activities-and-related-pathologies-a-narrative-review
#13
REVIEW
Andrea Bolognesi, Massimo Bortolotti, Maria Giulia Battelli, Letizia Polito
Taking into account the patient's gender is the first step towards more precise and egalitarian medicine. The gender-related divergences observed in purine catabolism and their pathological consequences are good examples of gender medicine differences. Uric acid is produced by the activity of xanthine oxidoreductase (XOR). The serum levels of both XOR activity and uric acid differ physiologically between the genders, being higher in men than in women. Their higher levels have been associated with gout and hypertension, as well as with vascular, cardiac, renal, and metabolic diseases...
February 7, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38396365/antiradical-capacity-assay-for-hydrophobic-substances-using-hemin-catalyzed-luminol-chemiluminescence-in-cationic-micelles
#14
JOURNAL ARTICLE
Cerize S Santos, Marcos P O Lemos, Larissa M Betschart, Wilhelm J Baader
Antioxidant substances which can diminish the steady-state concentration of free radicals in vivo are important in the human dietary to diminish the deleterious effects of oxidative stress. As the potential of certain substances as antioxidants is difficult to be verified in vivo, simple chemical in vitro assays which test the potential of substances as antioxidants are of great importance for the screening of new antioxidants. These assays measure the capacity of a substance to suppress free radicals...
February 23, 2024: Photochemistry and Photobiology
https://read.qxmd.com/read/38389057/effect-of-perla%C3%A2-a-new-cold-storage-solution-on-oxidative-stress-injury-and-early-graft-function-in-rat-kidney-transplantation-model
#15
JOURNAL ARTICLE
Mohamed Bejaoui, Chérifa Slim, Carmen Peralta, Hassen Ben Abdennebi
BACKGROUND: The composition of organ preservation solutions is crucial for maintaining graft integrity and early graft function after transplantation. The aim of this study is to compare new organ preservation solution PERLA® with the gold standard preservation solution University of Wisconsin (UW) regarding oxidative stress and early graft injury. METHODS: In order to assess oxidative stress after cold storage, kidney grafts have been preserved for 18 h at 4° C in either UW solution or PERLA® solution and then assessed for oxidative stress injury (protocol 1)...
February 22, 2024: BMC Nephrology
https://read.qxmd.com/read/38382713/fenpropathrin-provoked-kidney-damage-via-controlling-the-nlrp3-caspase-1-gsdmd-mediated-pyroptosis-the-palliative-role-of-curcumin-loaded-chitosan-nanoparticles
#16
JOURNAL ARTICLE
Yasmina M Abd-Elhakim, Amany Abdel-Rahman Mohamed, Ahmed E Noreldin, Tarek Khamis, Areej A Eskandrani, Ghalia Shamlan, Wafa S Alansari, Badriyah S Alotaibi, Manal Alosaimi, Mohammed Ageeli Hakami, Samah S Abuzahrah
This study assessed the ability of formulated curcumin-loaded chitosan nanoparticles (CU-CS-NPs) to reduce the kidney damage resulting from fenpropathrin (FPN) in rats compared to curcumin (CU) in rats. Sixty male Sprague Dawley rats were separated into six groups and orally administered 1 mL/kg b.wt corn oil, 50 mg CU/kg b.wt, 50 mg CU-CS-NPs /kg b.wt., 15 mg FPN /kg b.wt, CU+ FPN or CU-CS-NPs + FPN for 60 days. Then, serum renal damage products were assessed...
February 19, 2024: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/38376020/plasma-antioxidant-potential-measured-by-total-radical-trapping-antioxidant-parameter-in-a-cohort-of-multiple-sclerosis-patients
#17
JOURNAL ARTICLE
Marge Kartau, Joonas Kartau, Marjatta Pohja, Auli Verkkoniemi-Ahola
BACKGROUND: Oxidative injury has been implicated as a mediator of demyelination, axonal damage, and neurodegeneration in multiple sclerosis (MS). There is a high demand for oxidative injury biomarkers. The aim of the study was to evaluate MS patients' plasma antioxidant potential using the total radical trapping parameter (TRAP) assay and examine its usefulness as an MS disease biomarker. METHODS: A total number of 112 MS patients underwent an analysis of TRAP. In addition, plasma uric acid (UA) levels were analyzed...
January 2024: Brain and Behavior
https://read.qxmd.com/read/38369526/naringin-from-sweet-orange-peel-improves-testicular-function-in-high-fat-diet-induced-diabetic-rats-by-modulating-xanthine-oxidase-uric-acid-signaling-and-maintaining-redox-balance
#18
JOURNAL ARTICLE
Kazeem Bidemi Okesina, Adeyemi Fatai Odetayo, Wale Johnson Adeyemi, Ayodeji Johnson Ajibare, Akeem Ayodeji Okesina, Luqman Aribidesi Olayaki
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a metabolic disorder affecting many organs, including the testis. Naringin from orange peel extract (OPE) is a flavanone with fertility-enhancing properties. Hence, this study was designed to establish the effect of naringin on T2DM-induced testicular dysfunction. Thirty male (30) Wistar rats were randomized into five groups control, diabetes, diabetes + naringin, diabetes + OPE, and diabetes + metformin...
February 18, 2024: Laboratory Animal Research
https://read.qxmd.com/read/38362149/-annona-muricata-l-extract-restores-renal-function-oxidative-stress-immunohistochemical-structure-and-gene-expression-of-tnf-%C3%AE-il-%C3%AE-1-and-cyp2e1-in-the-kidney-of-dmba-intoxicated-rats
#19
JOURNAL ARTICLE
Mohamed M Zeweil, Asmaa F Khafaga, Sahar F Mahmoud, Lamiaa Wasef, Hamida Saleh, Attaa M Abd Elrehim, Naglaa F Bassuoni, Maha Abdullah Alwaili, Nizar H Saeedi, Hanan A Ghoneim
Introduction: 7,12-dimethylbenz (a) anthracene (DMBA) is a harmful polycyclic aromatic hydrocarbon derivative known for its cytotoxic, carcinogenic, and mutagenic effects in mammals and other species. Annona muricata, L. (Graviola; GRV) is a tropical fruit tree traditionally well-documented for its various medicinal benefits. This investigation is the first report on the potential antioxidant and antinfammatory reno-protective impact of GRV against DMBA-induced nephrotoxicity in rats. Methods: Forty male albino rats were allocated into four equal groups (n = 10)...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38358165/correlation-of-serum-uric-acid-levels-with-certain-anthropometric-parameters-in-prediabetic-and-drug-naive-diabetic-subjects
#20
JOURNAL ARTICLE
Ritu Tiwari, Shivam Verma, Narsingh Verma, Dileep Verma, Jagdish Narayan
INTRODUCTION: Uric acid is produced during the metabolism of nucleotide and adenosine triphosphate and contains the final product of human purine metabolism. It acts both as an antioxidant and pro-inflammatory marker and has a positive association with visceral fat in overweight subjects. The aim of the present study is to find an association of uric acid level with certain anthropometric parameters in subjects having type 2 diabetes. MATERIALS AND METHODS: The study included 124 urban drug-naive diabetic Indian subjects above 18 years of age from the general population of the city of North India...
2024: Annals of African Medicine
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