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Uric acid antioxidant

Habib Yaribeygi, Mohammad T Mohammadi, Ramin Rezaee, Amirhossein Sahebkar
Among several pathological mechanisms involved in diabetic nephropathy, oxidative stress, inflammation, and apoptosis play a prominent role. Fenofibrate, a peroxisome proliferator-activated receptor-α (PPAR-α) agonist, has markedly improved oxidative stress and inflammatory responses, but there is no evidence about its effects on interleukin-18 (IL-18), NADPH oxidase type 4 (NOX-4), and p53 expression in diabetic kidneys. The aim of this study was to evaluate possible effects of fenofibrate on improving the underlying mechanisms of diabetic nephropathy...
May 15, 2018: Journal of Cellular Biochemistry
Manel Gargouri, Ahlem Soussi, Amel Akrouti, Christian Magné, Abdelfattah El Feki
Our experimental work was aimed at evaluating the safety and protective effects of dietary spirulina supplementation on the kidney of newborn rats, the offspring of lead contaminated lactating mothers. Female rats were randomly divided into four groups: group I (control) was given a normal diet, group II (positive control, S) received a diet enriched with spirulina , group III received only lead through drinking water (Pb), and group IV received both a diet enriched with spirulina and lead contaminated water (S Pb)...
2018: EXCLI journal
Michael Maes, Kamila Landucci Bonifacio, Nayara Rampazzo Morelli, Heber Odebrecht Vargas, Estefânia Gastaldello Moreira, Drozdstoy St Stoyanov, Décio Sabbatini Barbosa, André F Carvalho, Sandra Odebrecht Vargas Nunes
Accumulating evidence shows that nitro-oxidative pathways play an important role in the pathophysiology of major depressive disorder (MDD) and bipolar disorder (BD) and maybe anxiety disorders. The current study aims to examine superoxide dismutase (SOD1), catalase, lipid hydroperoxides (LOOH), nitric oxide metabolites (NOx), advanced oxidation protein products (AOPP), malondialdehyde (MDA), glutathione (GSH), paraoxonase 1 (PON1), high-density lipoprotein cholesterol (HDL), and uric acid (UA) in participants with and without generalized anxiety disorder (GAD) co-occurring or not with BD, MDD, or tobacco use disorder...
May 7, 2018: Neurotoxicity Research
J R P T Castanheira, R E P Castanho, H Rocha, C Pagliari, M I S Duarte, A L S Therezo, E F B Chagas, L P A Martins
Trypanosoma cruzi infection stimulates inflammatory mediators which cause oxidative stress, and the use of antioxidants can minimize the sequelae of Chagas disease. In order to evaluate the efficacy of vitamin C in minimizing oxidative damage in Chagas disease, we orally administered ascorbic acid to Swiss mice infected with 5.0 × 104 trypomastigote forms of T. cruzi QM2 strain. These animals were treated for 60 days to investigate the acute phase and 180 days for the chronic phase. During the acute phase, the animals in the infected and treated groups demonstrated lower parasitemia and inflammatory processes were seen in more mice in these groups, probably due to the higher concentration of nitric oxide, which led to the formation of peroxynitrite...
May 4, 2018: Parasitology International
Hina Akram Mudassir, Shamim Akhter Qureshi, Muhammad Bilal Azmi, Muhammad Ahsan
This work was accomplished to assess the in-vitro antiglycation and antioxidant activities of ethanolic seeds extract of Centratherum anthelminticum (CSEt), followed by its in-vivo examination in type 2 diabetes. Overnight fasted rabbits were divided into control and diabetic groups. Rabbits in diabetic group were fed with 35% fructose solution to develop hyperglycemia that was well-monitored by glucometer. These were divided into diabetic control (distilled water 1ml/kg), positive control group (pioglitazone 15mg/kg) and two test groups (CSEt 400 and 600mg treated)...
May 2018: Pakistan Journal of Pharmaceutical Sciences
Rudra Prasad Dutta, M B Patil
ETHNOPHARMACOLOGICAL RELEVANCE: Zizyphus mauritiana (L.) of the family Rhamnaceae is a traditional herbal medicinal plant and commonly called as 'ber' (Indian jujube). It is traditionally used as food source and treats various diseases like malaria, asthma, pain killer, diarrhoea, typhoid, diabetes, and skin diseases, etc. AIM OF THE STUDY: This study aimed to evaluate the ability of extracts of barks of root and stem of Zizyphus mauritiana (ZM) to cure silica induced toxicity in Wistar albino rats...
May 1, 2018: Journal of Ethnopharmacology
Ji-Eun Park, Zia Yeom, Keun-Tae Park, Eun Hye Han, Heui Jong Yu, Hyo Seok Kang, Young-Hee Lim
The prevalence of gout is increasing worldwide, and control of serum uric acid level has been regarded as one of the therapeutic methods for gout. Inhibition of xanthine oxidase (XO) activity which can oxidize hypoxanthine to uric acid has been commonly proposed to decrease serum uric acid level. The aim of this study was to demonstrate the hypouricemic effect of ethanol extract of Aster glehni leaves (EAG) by in vitro and in vivo study in potassium oxonate (PO)-induced hyperuricemic rats. EAG possessed 132...
April 2018: Clinical Nutrition Research
Wale Johnson Adeyemi, Luqman Aribidesi Olayaki
The optimum therapy for the management of diabetes mellitus (DM) has been a controversial issue. Therefore, the study investigated the effects of salmon calcitonin (Sct) and/or omega-3 fatty acids {eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA); EPA/DHA ratio?=?3/2} relative to metformin in diabetic male Wistar rats. Forty rats were used for this study. They were randomly divided into 8 groups of five (5) rats each, which were treated with single or combined administration of salmon calcitonin, N-3 and metformin...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Ahlem Soussi, Manel Gargouri, Abdelfattah El Feki
Lead (Pb) is a toxic metal that induces a wide range of biochemical and physiological effects in humans. Oxidative damage has been proposed as a possible mechanism involved in Pb toxicity. The current study was carried out to evaluate the antioxidant activities of zinc (Zn) supplement against lead acetate-induced kidney injury in rats. In this study, adults male rats were treated for 15 days with Pb (0.344 g/kg body weight (bw)) associated or not with Zn (10 mg/kg bw). Our study showed that supplementation with Zn prevented renal dysfunction as indicated by plasma biomarkers (urea, uric acid, creatinine, lactate dehydrogenase, and alkaline phosphatase levels) and oxidative stress-related parameters (thiobarbituric acid reactive substances, protein carbonyl, advanced oxidation protein product, superoxide dismutase, catalase, glutathione peroxidase, and vitamins (A, E)) in kidney tissue...
January 1, 2018: Toxicology and Industrial Health
O Khukhlina, A Antoniv, L Kanovska, M Matushchak, V Vivsyannuk
The article presents a theoretical generalization of the research results the intensity of the antioxidant protection system and oxidative stress factors in patients with non-alcoholic steatohepatitis depending on the form of chronic kidney disease. The objective of the article - determining the pathogenetic role of the processes of antioxidant protection system in the development and interconnection mechanisms of non-alcoholic steatohepatitis (NASH) and obesity depending on the form and stage of chronic kidney disease (CKD)...
March 2018: Georgian Medical News
Anna Gawron-Skarbek, Agnieszka Guligowska, Anna Prymont-Przymińska, Dariusz Nowak, Tomasz Kostka
The native Total Antioxidant Capacity (TAC) of plasma and saliva is generally determined by uric acid (UA). Several studies have assessed the impact of habitual dietary antioxidative vitamin intake on TAC, but it remains unknown whether it influences Non-Urate Total Antioxidant Capacity (Nu-TAC), i.e., TAC after enzymatic UA elimination. The purpose of this study was to assess whether the intake of antioxidative vitamins C, E, and β-carotene, provided with usual daily food rations, affects plasma and salivary Nu-TAC...
April 23, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Cristiane Copetti, Fernanda Wouters Franco, Eduarda da Rosa Machado, Marcela Bromberger Soquetta, Andréia Quatrin, Vitor de Miranda Ramos, José Cláudio Fonseca Moreira, Tatiana Emanuelli, Cláudia Kaehler Sautter, Neidi Garcia Penna
Few studies investigated the biological effects of American grape cultivars. We investigated the metabolic response after acute consumption of grape juice or wine from Bordo grapes ( Vitis labrusca ) in a placebo-controlled crossover study with fifteen healthy volunteers. Blood samples were collected 1 hour after the intake of 100 mL of water, juice, or wine to measure TBARS, ABTS, FRAP, glucose, and uric acid levels. To evaluate differences in cellular response, intracellular reactive species production (DCFH-DA) and metabolic mitochondrial viability (MTT) were assessed after exposure of human neuron-like cells (SH-SY5Y) to juice or wine...
2018: Journal of Nutrition and Metabolism
Hong-Jin Tang, Wei Li, Mei Zhou, Li-Ying Peng, Jin-Xin Wang, Jia-Huang Li, Jun Chen
Xanthine oxidase, which catalyzes the oxidative reaction of hypoxanthine and xanthine into uric acid, is a key enzyme to the pathogenesis of hyperuricemia and gout. In this study, for the purpose of discovering novel xanthine oxidase (XO) inhibitors, a series of 2-arylbenzo[b]furan derivatives (3a-3d, 4a-4o and 6a-6d) were designed and synthesized. All these compounds were evaluated their xanthine oxidase inhibitory and antioxidant activities by using in vitro enzymatic assay and cellular model. The results showed that a majority of the designed compounds exhibited potent xanthine oxidase inhibitory effects and antioxidant activities, and compound 4a emerged as the most potent xanthine oxidase inhibitor (IC50  = 4...
May 10, 2018: European Journal of Medicinal Chemistry
Daryoush Hamidi Alamdari, B Fatemeh Nobakht, Mahdi Balali-Mood, Mohammad Reza Keramati, Amirhossein Sahebkar
The present study aimed to evaluate serum prooxidant -antioxidant balance (PAB) in an Iranian population exposed to sulfur mustard (SM) more than 20 years ago. In this study, 42 SM-exposed subjects and 30 unexposed subjects (as controls) were recruited. Serum PAB, biochemical, and hematological parameters were measured in all subjects. Correlation of PAB with biochemical and hematological parameters was determined. The mean PAB values in the SM-exposed group (82.5 ± 34.8 HK) were significantly higher than that in the control group [47...
April 23, 2018: Drug and Chemical Toxicology
Kalliopi Georgakouli, Eirini Manthou, Ioannis G Fatouros, Panagiotis Georgoulias, Chariklia K Deli, Yiannis Koutedakis, Yannis Theodorakis, Athanasios Z Jamurtas
Alcohol-induced oxidative stress is involved in the development and progression of various pathological conditions and diseases. On the other hand, exercise training has been shown to improve redox status, thus attenuating oxidative stress-associated disease processes. The purpose of the present study was to evaluate the effect of an exercise training program that has been previously reported to decrease alcohol consumption on blood redox status in heavy drinkers. In a non-randomized within-subject design, 11 sedentary, heavily drinking men (age: 30...
December 2, 2017: Alcohol
Mariano Zacarías-Flores, Martha A Sánchez-Rodríguez, Oswaldo Daniel García-Anaya, Elsa Correa-Muñoz, Víctor Manuel Mendoza-Núñez
BACKGROUND: Endocrine changes due to menopause have been associated to oxidative stress and muscle mass loss. The study objective was to determine the relationship between both variables in early postmenopause. MATERIAL AND METHODS: An exploratory, cross-sectional study was conducted in 107 pre- and postmenopausal women (aged 40-57 years). Levels of serum lipid peroxides and uric acid and enzymes superoxide dismutase and glutathione peroxidase, as well as total plasma antioxidant capacity were measured as oxidative stress markers...
April 9, 2018: Endocrinología, Diabetes y Nutrición
Neide Tomimura Costa, Bruna Miglioranza Scavuzzi, Tatiana Mayumi Veiga Iriyoda, Marcell Alysson Batisti Lozovoy, Daniela Frizon Alfieri, Fabiano Aparecido de Medeiros, Marcelo Cândido de Sá, Pâmela Lonardoni Micheletti, Bruno Alexandre Sekiguchi, Edna Maria Vissoci Reiche, Michael Maes, Andréa Name Colado Simão, Isaias Dichi
Oxidative stress plays a role in the pathophysiology of rheumatoid arthritis (RA). The aim of the present study was to verify the influence of metabolic syndrome (MetS) and disease-modifying antirheumatic drugs on nitrosative and oxidative biomarkers in patients with RA. A total of 177 patients with RA and 150 healthy volunteers participated in this study, which measured lipid hydroperoxides, advanced oxidation protein products (AOPP), nitric oxide metabolites (NOx), carbonyl protein, total radical-trapping antioxidant parameter (TRAP), uric acid (UA), and C-reactive protein (CRP)...
April 11, 2018: Clinical and Experimental Medicine
Yoonju Lee, Yeong-Hun Park, Jae Jung Lee, Young H Sohn, Jong-Min Lee, Phil Hyu Lee
INTRODUCTION: The pattern of resting-state networks is influenced by several factors besides the underlying pathological changes of Parkinson's disease (PD). Uric acid (UA), as an antioxidant, has a neuroprotective property against PD-related microenvironment; however, this effect would be gender-specific. We aimed to evaluate a gender-sensitive resting-state networks (RSN) according to the UA level in drug naïve de novo patients with PD to elucidate the role of antioxidant in cortical functional networks of PD...
March 26, 2018: Parkinsonism & related Disorders
Faiza Mejri, Slimen Selmi, Alice Martins, Haifa Benkhoud, Tarek Baati, Hedia Chaabane, Leila Njim, Maria L M Serralheiro, Amélia P Rauter, Karim Hosni
This study was aimed at investigating the chemical composition (proximate, minerals, fatty acids and phenolic compounds) and the in vitro (antimicrobial, radical scavenging, anti-acetylcholinesterase and protein denaturing activities) and in vivo (anti-diabetic and histo-protective effects in alloxan-induced diabetic mice) biological activities of broad bean pods (BBPs), a food waste by-product material. The results showed that BBPs have high dietary fiber (57.46%), carbohydrate (18.93%) and protein (13.81%) content versus low fat content (<1%) contributing to a low energy value of 139...
March 28, 2018: Food & Function
Habib Yaribeygi, Mohammad T Mohammadi, Ramin Rezaee, Amirhossein Sahebkar
Oxidative damage, inflammation and apoptosis play significant roles in diabetic nephropathy. Previous studies demonstrated anti-inflammatory and anti-oxidative effects of crocin, but there is no evidence about its effects on IL-18, NOX-4, and p53 expression in diabetic kidneys. The aim of this study was to evaluate possible effects of crocin on improving main mechanisms underlying diabetic nephropathy. Male Wistar rats were randomly divided into four separate groups as normal (C), normal treated (CC), diabetic (D), and diabetic treated (DC) (n = 6)...
March 25, 2018: Journal of Cellular Biochemistry
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